Information on EC 4.6.1.6 - cytidylate cyclase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY hide
4.6.1.6
-
RECOMMENDED NAME
GeneOntology No.
cytidylate cyclase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CTP = 3',5'-cyclic CMP + diphosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P-O bond cleavage
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)
-
CAS REGISTRY NUMBER
COMMENTARY hide
65357-82-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
mouse, strain BAGG-Swiss
-
-
Manually annotated by BRENDA team
Rattus norvegicus Lister Hooded
strain Lister Hooded
-
-
Manually annotated by BRENDA team
strain Wistar
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
CTP
3',5'-cyclic CMP + diphosphate
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
CTP
3',5'-cyclic CMP + diphosphate
show the reaction diagram
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate
ATP
-
enzyme dispersed from the membrane fraction of brain
deoxycholate
-
-
L-alpha-Phosphatidic acid
-
-
L-alpha-Phosphatidylethanolamine
-
-
L-alpha-Phosphatidylserine
-
-
methylanthraniloyl-ATP
methylanthraniloyl-CTP
methylanthraniloyl-GTP
methylanthraniloyl-ITP
methylanthraniloyl-UTP
Mn2+
-
above 3 mM
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Guanine nucleotide-binding protein
-
stimulation of cytidylate cyclase activity via activation of a guanine nucleotide-binding protein
-
L-alpha-phosphatidylcholine
-
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0125 - 0.4197
CTP
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.3 - 8.8
CTP
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.37 - 704
CTP
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000011 - 0.0000045
9-[2-(phosphonomethoxy)ethyl]adenine diphosphate
0.00058 - 0.0044
methylanthraniloyl-ATP
0.00008 - 0.0013
methylanthraniloyl-CTP
0.0028 - 0.0061
methylanthraniloyl-GTP
0.001 - 0.0057
methylanthraniloyl-ITP
0.0018 - 0.0038
methylanthraniloyl-UTP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
liver enzyme
9.4
-
enzyme dispersed from the membrane fraction of brain
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5 - 9.5
-
about 35% of activity maximum at pH 5.5, about 55% of activity maximum at pH 9.5
6 - 8.5
-
-
7.4 - 9.4
-
20% of activity maximum at physiological pH 7.4, maximal activity at pH 9.4, enzyme dispersed from the membrane fraction of brain
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4 - 45
-
-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE