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Information on EC 4.6.1.12 - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and Organism(s) Haemophilus influenzae and UniProt Accession P44815

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IUBMB Comments
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
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This record set is specific for:
Haemophilus influenzae
UNIPROT: P44815
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The taxonomic range for the selected organisms is: Haemophilus influenzae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mecs, mecps, ispdf, 2-c-methyl-d-erythritol 2,4-cyclodiphosphate synthase, 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase, 2c-methyl-d-erythritol-2,4-cyclodiphosphate synthase, 2-methylerythritol 2,4-cyclodiphosphate synthase, ygbb protein, mec synthase, 2-c-methyl-d-erythritol-2,4-cyclodiphosphate synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase
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MECDP-synthase
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MECPS
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SYSTEMATIC NAME
IUBMB Comments
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)
The enzyme from Escherichia coli requires Mg2+ or Mn2+. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
CAS REGISTRY NUMBER
COMMENTARY hide
287480-92-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop vapor diffusion method
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloned into pET17b for expression of the native polypeptide in Escherichia coli strain BL21
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lehmann, C.; Lim, K.; Toedt, J.; Krajewski, W.; Howard, A.; Eisenstein, E.; Herzberg, O.
Structure of 2C-methyl-D-erythrol-2,4-cyclodiphosphate synthase from Haemophilus influenzae: Activation by conformational transition
Proteins
49
135-138
2002
Haemophilus influenzae (P44815), Haemophilus influenzae
Manually annotated by BRENDA team