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Information on EC 4.6.1.1 - adenylate cyclase and Organism(s) Mus musculus and UniProt Accession Q8C0T9

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EC Tree
IUBMB Comments
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
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Mus musculus
UNIPROT: Q8C0T9
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
adenylate cyclase, adenylyl cyclase, adenyl cyclase, pituitary adenylate cyclase, edema factor, adenylylcyclase, soluble adenylyl cyclase, adenylate cyclase toxin, adcy5, aciii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
soluble adenylyl cyclase
-
3',5'-cyclic AMP synthetase
-
-
-
-
AC-V
-
-
AC-VI
-
-
AC4
-
isoform
AC7
-
isoform
ACIII
-
-
ACTP10
-
-
-
-
adenyl cyclase
-
-
-
-
adenylate cyclase 5
-
-
adenylate cyclase 6
-
-
adenylate cyclase type 5
-
Adenylate cyclase, olfactive type
-
-
-
-
adenylyl cyclase
adenylyl cyclase 1
-
-
adenylyl cyclase 2
-
adenylyl cyclase 5
-
adenylyl cyclase 6
-
isoform
adenylyl cyclase 8
-
-
adenylyl cyclase 9
-
-
adenylyl cyclase type 1
-
-
Adenylyl cyclase type 10
-
-
-
-
adenylyl cyclase type 5
-
-
adenylyl cyclase type 8
-
-
adenylyl cyclase type V
-
-
adenylyl cyclase type VI
-
-
adenylyl cyclase VI
-
-
adenylyl cyclase, type-V
-
-
adenylyl cyclase, type-VI
-
-
adenylyl cyclase-5
-
-
adenylyl cyclase-V
-
-
adenylyl cyclases 1
-
adenylyl cyclases 8
-
adenylylcyclase
-
-
-
-
ATP pyrophosphate-lyase
-
-
-
-
Ca(2+)-inhibitable adenylyl cyclase
-
-
-
-
Ca(2+)/calmodulin activated adenylyl cyclase
-
-
-
-
Ca-stimulated type 8 adenylyl cyclase
-
Ca2+-calmodulin stimulated adenylyl cyclase type 8
-
-
Ca2+-dependent adenylyl cyclase
-
-
Ca2+/calmodulin-stimulated adenylyl cyclase 1
-
calcium-sensitive adenylyl cyclase
-
calcium-stimulated adenylyl cyclase
-
class III AC
-
-
class III adenylyl cyclase
-
-
cyclase, adenylate
-
-
-
-
Edema factor
-
-
-
-
G protein-regulated adenylyl cyclase
-
Rutabaga protein
-
-
-
-
soluble adenylyl cyclase
-
-
type 1 AC
-
-
type 1 adenylyl cyclase
-
-
type 1 Ca2+/calmodulin-stimulated adenylyl cyclase
-
-
type 5 adenylyl cyclase
type 8 AC
-
type III adenylyl cyclase
-
-
xlAC
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
P-O bond cleavage
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9012-42-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
-
-
-
?
ATP
3',5'-cAMP + diphosphate
show the reaction diagram
-
-
-
-
?
ATP
3',5'-cyclic AMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
ATP
cAMP + diphosphate
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
-
-
-
?
ATP
3',5'-cyclic AMP + diphosphate
show the reaction diagram
ATP
3',5'-cyclic-AMP + diphosphate
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
-
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
stimulates the soluble adenylyl cyclase
HCO3-
stimulates the soluble adenylyl cyclase
additional information
-
isoform AC4 is insensitive to Ca2+
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl)acetic acid
-
i.e. PMC-4, type 2 enzyme, 50% inhibition at 6.998 mM, type 3 enzyme, 50% inhibition at 0.117 mM, type 5 enzyme, 50% inhibition at 0.22 mM
2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio-]triphosphate
-
inhibits AC5, reduces basal L-type Ca2+ currents as a function of time, significantly and almost completely diminishes the increase of L-type Ca2+ currents due to isoproterenol, basal and isoproterenol-stimulated inhibition of L-type Ca2+ currents is concentration-dependent
2'(3')-O-(N-methylanthraniloyl)-ITP
-
most potent inhibitor of heart adenylyl cyclase and recombinant AC5
2',5'-dideoxy-3'-ATP
a P-site inhibitor, binds to the cytoplasmic domains, structure overview
2-(4-(6-amino-9H-purin-9-yl)cyclopent-2-en-1-yl)-N-hydroxyacetamide
-
i.e. PMC-3, type 2 enzyme, 50% inhibition at 3.76 mM, type 3 enzyme, 50% inhibition at 0.098 mM, type 5 enzyme, 50% inhibition at 0.076 mM
2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
i.e. Ara-Ade, type 2 enzyme, 50% inhibition at 7.202 mM, type 3 enzyme, 50% inhibition at 0.375 mM, type 5 enzyme, 50% inhibition at 0.0098mM
2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one
-
i.e. RS-2 or NKY80, type 2 enzyme, 50% inhibition at 2.63 mM, type 3 enzyme, 50% inhibition at 0.2264 mM, type 5 enzyme, 50% inhibition at 0.015 mM
2-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one
-
i.e.RS-4, type 3 enzyme, 50% inhibition at 6.61 mM, type 5 enzyme, 50% inhibition at 1.988 mM
2-amino-7-(4-methoxyphenyl)-7,8-dihydroquinazolin-5(6H)-one
-
i.e. RS-1, type 2 enzyme, 50% inhibition at 2.64 mM, type 3 enzyme, 50% inhibition at 1.32 mM, type 5 enzyme, 50% inhibition at 1.95 mM
2-amino-7-phenyl-7,8-dihydroquinazolin-5(6H)-one
-
i.e. RS-3, type 2 enzyme, 50% inhibition at 6.31 mM, type 3 enzyme, 50% inhibition at 0.56 mM, type 5 enzyme, 50% inhibition at 0.21 mM
3'-AMP
-
type 2 enzyme, 50% inhibition at 0.263 mM, type 3 enzyme, 50% inhibition at 0.030 mM, type 5 enzyme, 50% inhibition at 0.015 mM
3-(6-amino-9H-purin-9-yl)-N-hydroxycyclopentanecarboxamide
-
i.e. PMC-6, type 2 enzyme, 50% inhibition at 0.065 mM, type 3 enzyme, 50% inhibition at 0.011 mM, type 5 enzyme, 50% inhibition at 0.00032 mM
4-(6-amino-9H-purin-9-yl)-N-hydroxybutanamide
-
i.e. PMC-2, type 3 enzyme, 50% inhibition at 0.32 mM, type 5 enzyme, 50% inhibition at 0.13 mM
4-(6-amino-9H-purin-9-yl)-N-hydroxycyclopent-2-ene-1-carboxamide
-
i.e. PMC-5, type 2 enzyme, 50% inhibition at 6.02 mM, type 3 enzyme, 50% inhibition at 0.137 mM, type 5 enzyme, 50% inhibition at 0.046 mM
5-(6-amino-9H-purin-9-yl)-N-hydroxypentanamide
-
i.e. PMC-1, type 2 enzyme, 50% inhibition at 1.303 mM, type 3 enzyme, 50% inhibition at 0.154 mM, type 5 enzyme, 50% inhibition at 0.030 mM
5-(6-amino-9H-purin-9-yl)tetrahydrofuran-3-ol
-
i.e. 2'5'-dd-Ado, type 2 enzyme, 50% inhibition at 2.382 mM, type 3 enzyme, 50% inhibition at 0.253 mM, type 5 enzyme, 50% inhibition at 0.0016 mM
9-(tetrahydrofuran-2-yl)-9H-purin-6-amine
-
i.e. SQ22536, type 2 enzyme, 50% inhibition at 0.285 mM, type 3 enzyme, 50% inhibition at 0.101 mM, type 5 enzyme, 50% inhibition at 0.0022 mM
9-CPA
-
a adenylate cyclase P-site inhibitor
BAPTA
-
inhibits calcium-stimulated AC
carbamazepine
-
carbamazepine preferentially inhibits forskolin-stimulated isoforms AC5 and AC1 and all D1 agonist-stimulated adenylate cyclases, with isoforms AC5 and AC7 being the most sensitive. When compared to 1 or 3 mM Mg2+, 10 mM Mg2+ reduces lithium-induced AC5 inhibition by 70%. Carbamazepine competes for adenylate cylcase's catechol-estrogen site
cytidine 5'-(gamma-thio)triphosphate
-
-
delta opioid receptor agonist DPDPE
-
i..e. d-Pen2,d-Pen5 enkephalin, delta opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity
-
delta opioid receptor agonist DT II
-
i.e.(d-Ala2)-deltorphin II, delta opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity
-
Gi GTP-binding protein
-
inhibitory G-protein signaling acts presynaptically to regulate release, and, when paired with elevations in the concentration of cyclic GMP, converts a transient cyclic GMP-induced depression into a long-lasting decrease in release, overview
-
Gialpha
-
inhibits AC5 and AC6
-
guanosine 5'-(beta,gamma-imido)triphosphate
-
-
guanosine 5'-(gamma-thio)triphosphate
-
-
inhibitory G protein
-
inosine 5'-(beta,gamma-imido)triphosphate
-
-
inosine 5'-(gamma-thio)triphosphate
-
-
Li+
-
lithium preferentially inhibits adenylyl cyclase V and VII isoforms, moderately also isozyme AC-II, but does not inhibit Ca2+-activated isozymes AC-I and AC-VIII, it interferes with the transduction pathways mediated via isozymes AC-V and AC-IIV. The inhibitor effect is abolished for the superactivated isozyme, overview
lithium
-
lithium preferentially inhibits isoform AC5, lithium competes with Mg2+, which is essential for adenylate cyclase activity
NKY80
-
selective adenylyl cyclase-V inhibitor, completely blocks both 5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid–stimulated cAMP formation and renin release
NO
-
inhibits forskolin- and Galphas-stimulated activity of recombinant AC5 and AC6, but neither AC1 nor AC2 in N18TG2 cells
opioid receptor agonist DAMGO
-
i.e. (d-Ala2,N-MePhe4,Gly5-ol)enkephalin, micro opioid receptor agonist, 0.001 mM significantly represses forskolin-stimulated adenylyl cyclase activity
-
quinpirole
-
inhibits the enzyme via Gi protein
SQ 22536
-
adenylyl cyclase inhibitor, blocks both generation of cAMP and the release of renin, completely blocks 5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid–stimulated renin release and cAMP content
SQ22536
-
a adenylate cyclase P-site inhibitor
U50488H
-
kappa opioid receptor agonist
U69593
-
kappa opioid receptor agonist
uridine 5'-(beta,gamma-imido)triphosphate
-
-
uridine 5'-(gamma-thio)triphosphate
-
-
xanthosine 5'-(beta,gamma-imido)triphosphate
-
-
xanthosine 5'-(gamma-thio)triphosphate
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid
A23187
-
activates isozymes AC-I and AC-III
Calmodulin
cholera toxin
-
-
-
dopamine
-
about 2fold activation by 0.1 mM
epinephrine
-
about 2fold activation by 0.1 mM
forskolin
G-protein coupled receptor
-
-
-
Galphas
-
-
-
Gbetagamma
-
stimulates AC2
-
GTP
-
activation
GTP-gamma-S
-
activation
GTPgammaS
-
in the presence of Mg2+, GTPgammaS increases adenylyl cyclase activity 4fold, with an EC50 value of 80 nM
guanosine 5'-(beta,gamma-imido)triphosphate
-
activation
HCO3-
IBMX
-
increases basal renin release
isoproterenol
-
in the presence of GTP (0.01 mM), isoproterenol increases adenylyl cyclase activity approximately 2fold, with an EC50 value of 12 nM
NaF
-
activation
NKH477
-
a water soluble forskolin analogue that directly stimulates AC
norepinephrine
-
about 2fold activation by 0.1 mM
pertussis toxin
-
-
-
PMA
-
potentiates drug-stimulated cAMP accumulation
SKF-82958
stimulating G protein
-
Vasoactive intestinal peptide
-
activation
Vasopressin
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.1 - 0.15
ATP
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1 - 2.9
CTP
0.033 - 0.071
cytidine 5'-(gamma-thio)triphosphate
0.44 - 0.67
GTP
2.4 - 3
guanosine 5'-(beta,gamma-imido)triphosphate
0.4 - 0.41
guanosine 5'-(gamma-thio)triphosphate
0.35 - 0.48
inosine 5'-(beta,gamma-imido)triphosphate
0.02 - 0.021
inosine 5'-(gamma-thio)triphosphate
0.6 - 0.99
ITP
2.5 - 2.8
uridine 5'-(beta,gamma-imido)triphosphate
0.015 - 0.051
uridine 5'-(gamma-thio)triphosphate
1.1 - 2.2
UTP
10
xanthosine 5'-(beta,gamma-imido)triphosphate
0.02 - 0.025
xanthosine 5'-(gamma-thio)triphosphate
0.55 - 0.95
XTP
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000151
recombinant isozyme AC2 in HEK-293 cells
0.000335
recombinant isozyme AC5 in HEK-293 cells
0.001487
chimeric mutant dimer of AC2/AC5
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
-
assay at
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2 - 9
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
all 9 membrane-associated adenylate cyclases
Manually annotated by BRENDA team
-
highest AC1 expression, present in molecular layer, weak AC8 expression at postnatal day 7 and decreases further by postnatal day 14
Manually annotated by BRENDA team
-
ACIII localizes to cilia in adults, throughout the cortex, including the subiculum, as well as the retrosplenial granular, visual, motor, and orbital cortices
Manually annotated by BRENDA team
-
all 9 membrane-associated adenylate cyclases
Manually annotated by BRENDA team
-
isoform AC5
Manually annotated by BRENDA team
-
the insulin-secreting cells, derived from in vivo immortalized insulin-secreting pancreatic beta cells, are endogenously expressing Ca2+-sensitive AC isoforms
Manually annotated by BRENDA team
-
primarly expresses AC6
Manually annotated by BRENDA team
-
all 9 membrane-associated adenylate cyclases
Manually annotated by BRENDA team
-
pheromone detection in male mice depends on signaling through AC3
Manually annotated by BRENDA team
-
cyclic AMP levels in photoreceptor cells are highest in darkness and reduced by light exposure
Manually annotated by BRENDA team
-
diffuse expression of AC1
Manually annotated by BRENDA team
additional information
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
isozyme AC8 is preferentially localized in the presynaptic active zone and copurifies with Rab3A
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
knockdown of AC5 and AC6 with siRNA reduces the ability of UDP to decrease cAMP
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ADCYA_MOUSE
1614
0
186412
Swiss-Prot
other Location (Reliability: 4)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
120000
-
adenylyl cyclase-V, Western blotting
120000 - 140000
-
SDS-PAGE
123000
-
AC1, immunoblot analysis
135000
171000
-
x * 171000, immunoblot, full length sAC
187000
full-length enzyme variant
192000
-
AC9, immunoblotting
46000
-
1 * 46000, immunoblot, truncated sAC resulting from alternative splicing
49000
-
gel filtration, recombinant truncated sAC
50000
testis splice variant
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 171000, immunoblot, full length sAC
dimer
adenylate cyclases 2 and 5 can form a functional heterodimeric complex in HEK-293 cells
monomer
-
1 * 46000, immunoblot, truncated sAC resulting from alternative splicing
additional information
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
homology modeling and comparative electrostatic analysis of the catalytic domains of all nine transmembrane adenylate cyclase isoforms providing support for the positioning of the binding site of the inhibitory protein Gialpha at a pseudo-symmetric position to the stimulatory Gsalpha binding site, a structural interpretation of the Gbetacamma interaction with adenylae cyclases 2, 4, and 7 and a new binding site for RGS2
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Y1082L
-
mutation in AC9 confers both binding and activation by forskolin
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
AC5, RT-PCR expression analysis
-
expressed in COS-7 cells
-
expressed in Sf9 insect cells
-
expression analysis of isozymes ACI-ACIX in wild-type and hypoxic retinas by real time PCR, overview
-
expression in HEK 293 cells
-
expression in human embryonic kidney, i.e. HEK-293, cells
-
expression in Sf9 cells
expression of fluorescent EGFP-tagged isozyme AC5, and of the fluorescence-tagged chimeric mutant dimer of AC2/AC5 in HEK-293-F cells, subcellular distribution, overview
expression of fluorescent Luc-tagged isozyme AC2, and of the fluorescence-tagged chimeric mutant dimer of AC2/AC5 in HEK-293-F cells, subcellular distribution, overview
expression of full length and truncated sAC in HEK293 cells
-
expression of isozyme ACVI with an AU1 tag, a 6-amino acid epitope DTYRY, in Rattus norvegicus myocytes using an adenoviral vector leading to increased phosphorylation of phospholamban independently of beta-adrenergic receptor stimulation, and to increased Akt activity, 5fold, and phosphorylation at both the Ser473 and Thr308 sites, but does not change the levels of Akt protein, phosphorylation of GSK alpha- and beta-isoforms is also increased by the gene transfer, overview
-
gene Adcy1, DNA and amino acid sequence determination and analysis, expression analysis, genotyping
-
overexpression of nine membrane-bound isozymes in COS7 cells in absence of the D1 receptor
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
-
technical problems of AC detection, some of which caused by poor quality-control of commercially supplied antibodies. Intracellular targeting of ACs may be isoform-specific and also dependent on the cellular context of expression
drug development
-
AC1 is a potential drug target site to improve long-term remote memor
medicine
pharmacology
-
activation of cardiac adenylyl cyclase isozyme ACVI expression increases the function of the failing ischemic heart in mice, overview. Increased left ventricular ACVI content also markedly reduces mortality and increases left ventricular function after acute myocardial infarction in mice
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Watson, P.A.; Krupinski, J.; Kempinski, A.M.; Frankenfeld, C.D.
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells
J. Biol. Chem.
269
28893-28898
1994
Mus musculus
Manually annotated by BRENDA team
Premont, R.T.; Matsuoka, I.; Mattei, M.G.; Pouille, Y.; Defer, N.; Hanoune, J.
Identification and characterization of a widely expressed form of adenylyl cyclase
J. Biol. Chem.
271
13900-13907
1996
Rattus norvegicus, Mus musculus (P51830), Mus musculus
Manually annotated by BRENDA team
Pozo, D.; Segura, J.J.; Carrero, I.; Guijarro, L.G.; Prieto, J.C.; Calvo, J.R.
Characterization of adenylyl cyclase stimulated by VIP in rat and mouse peritoneal macrophage membranes
Biochim. Biophys. Acta
1312
249-254
1996
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Defer, N.; Best-Belpomme, M.; Hanoune, J.
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
Am. J. Physiol.
279
F400-F416
2000
Gallus gallus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Jaiswal, B.S.; Conti, M.
Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase
J. Biol. Chem.
276
31698-31708
2001
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Baker, L.P.; Nielsen, M.D.; Impey, S.; Hacker, B.M.; Poser, S.W.; Chan, M.Y.M.; Storm, D.R.
Regulation and immunohistochemical localization of bg-stimulated adenylyl cyclases in mouse hippocampus
J. Neurosci.
19
180-192
1999
Mus musculus
Manually annotated by BRENDA team
Gille, A.; Guo, J.; Mou, T.C.; Doughty, M.B.; Lushington, G.H.; Seifert, R.
Differential interactions of G-proteins and adenylyl cyclase with nucleoside 5'-triphosphates, nucleoside 5'-[g-thio]triphosphates and nucleoside 5'-[b,g-imido]triphosphates
Biochem. Pharmacol.
71
89-97
2005
Mus musculus
Manually annotated by BRENDA team
Iwatsubo, K.; Minamisawa, S.; Tsunematsu, T.; Nakagome, M.; Toya, Y.; Tomlinson, J.E.; Umemura, S.; Scarborough, R.M.; Levy, D.E.; Ishikawa, Y.
Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration
J. Biol. Chem.
279
40938-40945
2004
Mus musculus
Manually annotated by BRENDA team
Paunescu, T.G.; Da Silva, N.; Russo, L.M.; McKee, M.; Lu, H.A.; Breton, S.; Brown, D.
Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
Am. J. Physiol. Renal Physiol.
294
F130-F138
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Strait, K.A.; Stricklett, P.K.; Kohan, D.E.
Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice
BMC Nephrol.
8
8
2007
Mus musculus
Manually annotated by BRENDA team
Linder, J.U.
Class III adenylyl cyclases: molecular mechanisms of catalysis and regulation
Cell. Mol. Life Sci.
63
1736-1751
2006
Bacillus anthracis, Bordetella pertussis, Saccharomyces cerevisiae, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chloroflexus aurantiacus, Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Euglena gracilis, Mus musculus, Myxococcus xanthus, Pseudomonas aeruginosa, Rattus norvegicus, Sinorhizobium meliloti, Schizosaccharomyces pombe, Arthrospira platensis, Trypanosoma brucei, Ustilago maydis, Yersinia enterocolitica, Mycobacterium tuberculosis (P9WQ35), Nostoc sp. PCC 7120 = FACHB-418 (Q7A2D9), Nostoc sp. PCC 7120 = FACHB-418 (Q8YMH0), Nostoc sp. PCC 7120 = FACHB-418 (Q8YVS0), Mycobacterium tuberculosis H37Rv (P9WQ35)
Manually annotated by BRENDA team
Xie, F.; Garcia, M.A.; Carlson, A.E.; Schuh, S.M.; Babcock, D.F.; Jaiswal, B.S.; Gossen, J.A.; Esposito, G.; van Duin, M.; Conti, M.
Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization
Dev. Biol.
296
353-362
2006
Mus musculus
Manually annotated by BRENDA team
Beazely, M.A.; Watts, V.J.
Regulatory properties of adenylate cyclases type 5 and 6: A progress report
Eur. J. Pharmacol.
535
1-12
2006
Cricetulus griseus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Ortiz-Capisano, M.C.; Ortiz, P.A.; Harding, P.; Garvin, J.L.; Beierwaltes, W.H.
Decreased intracellular calcium stimulates renin release via calcium-inhibitable adenylyl cyclase
Hypertension
49
162-169
2007
Mus musculus, Mus musculus C57/B6
Manually annotated by BRENDA team
Ortiz-Capisano, M.C.; Ortiz, P.A.; Harding, P.; Garvin, J.L.; Beierwaltes, W.H.
Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells
Hypertension
49
618-624
2007
Mus musculus, Mus musculus C57/B6
Manually annotated by BRENDA team
Bishop, G.A.; Berbari, N.F.; Lewis, J.; Mykytyn, K.
Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain
J. Comp. Neurol.
505
562-571
2007
Mus musculus, Mus musculus 129:BL6
Manually annotated by BRENDA team
Rottlaender, D.; Matthes, J.; Vatner, S.F.; Seifert, R.; Herzig, S.
Functional adenylyl cyclase inhibition in murine cardiomyocytes by 2(3)-O-(N-methylanthraniloyl)-guanosine 5-[gamma-thio]triphosphate
J. Pharmacol. Exp. Ther.
321
608-615
2007
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Watts, V.J.
Adenylyl cyclase isoforms as novel therapeutic targets: an exciting example of excitotoxicity neuroprotection
Mol. Interv.
7
70-73
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Antoni, F.A.; Wiegand, U.K.; Black, J.; Simpson, J.
Cellular localisation of adenylyl cyclase: a post-genome perspective
Neurochem. Res.
31
287-295
2006
Homo sapiens, Macaca sp., Mus musculus, Rattus norvegicus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Conti, A.C.; Maas, J.W.; Muglia, L.M.; Dave, B.A.; Vogt, S.K.; Tran, T.T.; Rayhel, E.J.; Muglia, L.J.
Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain
Neuroscience
146
713-729
2007
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Willoughby, D.; Cooper, D.M.
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains
Physiol. Rev.
87
965-1010
2007
Aplysia sp., Canis lupus familiaris, Oryctolagus cuniculus, Dictyostelium discoideum, Drosophila sp. (in: flies), Homo sapiens, Mus musculus, Paramecium sp., Rattus norvegicus, Tetrahymena sp., Plasmodium sp.
Manually annotated by BRENDA team
Kim, K.S.; Lee, K.W.; Lee, K.W.; Im, J.Y.; Yoo, J.Y.; Kim, S.W.; Lee, J.K.; Nestler, E.J.; Han, P.L.
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action
Proc. Natl. Acad. Sci. USA
103
3908-3913
2006
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Bosier, B.; Hermans, E.; Lambert, D.M.
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression
Biochem. Pharmacol.
77
216-227
2009
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Zachariou, V.; Liu, R.; LaPlant, Q.; Xiao, G.; Renthal, W.; Chan, G.C.; Storm, D.R.; Aghajanian, G.; Nestler, E.J.
Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies
Biol. Psychiatry
63
1013-1021
2008
Mus musculus (O88444), Mus musculus (P97490)
Manually annotated by BRENDA team
Krishnan, V.; Graham, A.; Mazei-Robison, M.S.; Lagace, D.C.; Kim, K.S.; Birnbaum, S.; Eisch, A.J.; Han, P.L.; Storm, D.R.; Zachariou, V.; Nestler, E.J.
Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting
Biol. Psychiatry
64
336-343
2008
Mus musculus (O88444), Mus musculus (P84309), Mus musculus (P97490)
Manually annotated by BRENDA team
Baragli, A.; Grieco, M.L.; Trieu, P.; Villeneuve, L.R.; Hebert, T.E.
Heterodimers of adenylyl cyclases 2 and 5 show enhanced functional responses in the presence of Galpha s
Cell. Signal.
20
480-492
2008
Mus musculus (P84309), Mus musculus (Q80TL1), Mus musculus
Manually annotated by BRENDA team
Vatner, S.F.; Yan, L.; Ishikawa, Y.; Vatner, D.E.; Sadoshima, J.
Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress
Circ. J.
73
195-200
2009
Mus musculus
Manually annotated by BRENDA team
Mann, L.; Heldman, E.; Shaltiel, G.; Belmaker, R.H.; Agam, G.
Lithium preferentially inhibits adenylyl cyclase V and VII isoforms
Int. J. Neuropsychopharmacol.
11
533-539
2008
Mus musculus
Manually annotated by BRENDA team
Lai, N.C.; Tang, T.; Gao, M.H.; Saito, M.; Takahashi, T.; Roth, D.M.; Hammond, H.K.
Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice
J. Am. Coll. Cardiol.
51
1490-1497
2008
Mus musculus
Manually annotated by BRENDA team
Okumura, S.; Tsunematsu, T.; Bai, Y.; Jiao, Q.; Ono, S.; Suzuki, S.; Kurotani, R.; Sato, M.; Minamisawa, S.; Umemura, S.; Ishikawa, Y.
Type 5 adenylyl cyclase plays a major role in stabilizing heart rate in response to microgravity induced by parabolic flight
J. Appl. Physiol.
105
173-179
2008
Mus musculus (P84309), Mus musculus, Mus musculus C57BL/6 (P84309)
Manually annotated by BRENDA team
Gao, M.H.; Tang, T.; Guo, T.; Miyanohara, A.; Yajima, T.; Pestonjamasp, K.; Feramisco, J.R.; Hammond, H.K.
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes
J. Biol. Chem.
283
33527-33535
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Kim, K.S.; Lee, K.W.; Baek, I.S.; Lim, C.M.; Krishnan, V.; Lee, J.K.; Nestler, E.J.; Han, P.L.
Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-related behavior
J. Neurochem.
107
105-115
2008
Mus musculus
Manually annotated by BRENDA team
Jackson, C.R.; Chaurasia, S.S.; Zhou, H.; Haque, R.; Storm, D.R.; Michael Iuvone, P.
Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells
J. Neurochem.
109
148-157
2009
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Shan, Q.; Chan, G.C.; Storm, D.R.
Type 1 adenylyl cyclase is essential for maintenance of remote contextual fear memory
J. Neurosci.
28
12864-12867
2008
Mus musculus
Manually annotated by BRENDA team
Moore, S.W.; Lai Wing Sun, K.; Xie, F.; Barker, P.A.; Conti, M.; Kennedy, T.E.
Soluble adenylyl cyclase is not required for axon guidance to netrin-1
J. Neurosci.
28
3920-3924
2008
Mus musculus (Q8C0T9), Rattus norvegicus (Q9Z286)
Manually annotated by BRENDA team
Wang, H.; Wu, L.J.; Zhang, F.; Zhuo, M.
Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors
J. Neurosci.
28
4385-4397
2008
Mus musculus (O88444), Mus musculus (P97490)
Manually annotated by BRENDA team
Zhang, M.; Moon, C.; Chan, G.C.; Yang, L.; Zheng, F.; Conti, A.C.; Muglia, L.; Muglia, L.J.; Storm, D.R.; Wang, H.
Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory
J. Neurosci.
28
4736-4744
2008
Mus musculus, Mus musculus (P97490), Mus musculus C57BL/6, Mus musculus C57BL/6 (P97490)
Manually annotated by BRENDA team
Moulder, K.L.; Jiang, X.; Chang, C.; Taylor, A.A.; Benz, A.M.; Conti, A.C.; Muglia, L.J.; Mennerick, S.
A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing
J. Neurosci.
28
5159-5168
2008
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Iwasato, T.; Inan, M.; Kanki, H.; Erzurumlu, R.S.; Itohara, S.; Crair, M.C.
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development
J. Neurosci.
28
5931-5943
2008
Mus musculus
Manually annotated by BRENDA team
Bailey, C.P.; Nicholls, R.E.; Zhang, X.L.; Zhou, Z.Y.; Mueller, W.; Kandel, E.R.; Stanton, P.K.
Galpha(i2) inhibition of adenylate cyclase regulates presynaptic activity and unmasks cGMP-dependent long-term depression at Schaffer collateral-CA1 hippocampal synapses
Learn. Mem.
15
261-270
2008
Mus musculus
Manually annotated by BRENDA team
Martin, A.C.; Willoughby, D.; Ciruela, A.; Ayling, L.J.; Pagano, M.; Wachten, S.; Tengholm, A.; Cooper, D.M.
Capacitative Ca2+ entry via Orai1 and STIM1 regulates adenylyl cyclase type 8
Mol. Pharmacol.
75
830-842
2009
Mus musculus, Rattus norvegicus (P40146)
Manually annotated by BRENDA team
Ristori, C.; Ferretti, M.E.; Pavan, B.; Cervellati, F.; Casini, G.; Catalani, E.; Dal Monte, M.; Biondi, C.
Adenylyl cyclase/cAMP system involvement in the antiangiogenic effect of somatostatin in the retina. Results from transgenic mice
Neurochem. Res.
33
1247-1255
2008
Mus musculus
Manually annotated by BRENDA team
Sadana, R.; Dessauer, C.W.
Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies
Neurosignals
17
5-22
2009
Mammalia, Mus musculus, Mus musculus (O88444), Mus musculus (P51829), Mus musculus (P84309), Mus musculus (P97490), Mus musculus (Q01341), Mus musculus (Q80TL1), Mus musculus (Q8VHH7)
Manually annotated by BRENDA team
Marquez, B.; Suarez, S.S.
Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation
Reprod. Fertil. Dev.
20
247-252
2008
Mus musculus (Q8C0T9)
Manually annotated by BRENDA team
von Hayn, K.; Werthmann, R.C.; Nikolaev, V.O.; Hommers, L.G.; Lohse, M.J.; Buenemann, M.
Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells
Am. J. Physiol. Cell Physiol.
298
C324-C332
2010
Mus musculus
Manually annotated by BRENDA team
Strait, K.A.; Stricklett, P.K.; Chapman, M.; Kohan, D.E.
Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouse
Am. J. Physiol. Renal Physiol.
298
F859-F867
2010
Mus musculus
Manually annotated by BRENDA team
Mann, L.; Heldman, E.; Bersudsky, Y.; Vatner, S.F.; Ishikawa, Y.; Almog, O.; Belmaker, R.H.; Agam, G.
Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect
Bipolar. Disord.
11
885-896
2009
Mus musculus
Manually annotated by BRENDA team
Goettle, M.; Geduhn, J.; Koenig, B.; Gille, A.; Hoecherl, K.; Seifert, R.
Characterization of mouse heart adenylyl cyclase
J. Pharmacol. Exp. Ther.
329
1156-1165
2009
Mus musculus
Manually annotated by BRENDA team
Blount, M.
A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct
Am. J. Physiol.
298
F857-F858
2010
Mus musculus
Manually annotated by BRENDA team
Sugano, Y.; Lai, N.C.; Gao, M.H.; Firth, A.L.; Yuan, J.X.; Lew, W.Y.; Hammond, H.K.
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart
Biochem. Biophys. Res. Commun.
405
349-355
2011
Mus musculus
Manually annotated by BRENDA team
Zhao, Z.; Babu, G.; Wen, H.; Fefelova, N.; Gordan, R.; Sui, X.; Yan, L.; Vatner, D.; Vatner, S.; Xie, L.
Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart
Am. J. Physiol.
308
H240-H249
2015
Mus musculus (P84309)
Manually annotated by BRENDA team
Tong, R.; Wade, R.; Bruce, N.
Comparative electrostatic analysis of adenylyl cyclase for isoform dependent regulation properties
Proteins
84
1844-1858
2016
Mus musculus (O88444), Mus musculus (P51829), Mus musculus (P51830), Mus musculus (P84309), Mus musculus (P97490), Mus musculus (Q01341), Mus musculus (Q80TL1), Mus musculus (Q8VHH7), Mus musculus (Q91WF3)
Manually annotated by BRENDA team