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Information on EC 4.6.1.1 - adenylate cyclase
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4.6.1.1 adenylate cyclaseIUBMB Comments
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
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Word Map
- 4.6.1.1
- camp
- agonist
- forskolin
-
beta-adrenergic
- pertussis
- phosphodiesterase
- isoproterenol
- prostaglandin
- gtp
- dopamine
- monophosphate
- cholera
- subtypes
- guanine
- pka
-
desensitization
- phospholipase
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forskolin-stimulated
- g-proteins
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camp-dependent
- epinephrine
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pacap
- catecholamine
- parathyroid
- norepinephrine
-
adrenergic
-
muscarinic
-
vasoactive
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guanylate
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receptor-mediated
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beta-adrenoceptor
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protein-coupled
- glucagon
- bordetella
- vasopressin
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toxin-sensitive
- naf
-
inotropic
-
gtp-binding
- 3',5'-monophosphate
- carbachol
- propranolol
-
radioligands
-
dibutyryl
- ibmx
-
adp-ribosylation
- somatostatin
- isoprenaline
- medicine
- pharmacology
- drug development
- rolipram
- 3-isobutyl-1-methylxanthine
- analysis
- molecular biology
The enzyme appears in viruses and cellular organisms
Synonyms
adenylate cyclase, adenylyl cyclase, adenyl cyclase, pituitary adenylate cyclase, edema factor, adenylylcyclase, soluble adenylyl cyclase, adenylate cyclase toxin, adcy5, aciii, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3',5'-cyclic AMP synthetase
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AC2
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AC3
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ACTP10
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adenyl cyclase
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Adenylate cyclase, olfactive type
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adenylyl cyclase
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Adenylyl cyclase type 10
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adenylylcyclase
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ATP pyrophosphate-lyase
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Ca(2+)-inhibitable adenylyl cyclase
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Ca(2+)/calmodulin activated adenylyl cyclase
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cyclase, adenylate
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Edema factor
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Rutabaga protein
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xlAC
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
P-O bond cleavage
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SYSTEMATIC NAME
IUBMB Comments
ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
Also acts on dATP to form 3',5'-cyclic dAMP. Requires pyruvate. Activated by NAD+ in the presence of EC 2.4.2.31 NAD(P)+---arginine ADP-ribosyltransferase.
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CAS REGISTRY NUMBER
COMMENTARY
9012-42-4
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP
3',5'-cAMP + diphosphate
in CyaB1 only GAFB binds cAMP
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
GAF domains bind cAMP and thereby increase the adenylate cyclase activity 27fold, thus functioning as an autoactivating switch and creating a feed-forward stimulatory mechanism
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additional information
GAF domains bind cAMP and thereby increase the adenylate cyclase activity 27fold, thus functioning as an autoactivating switch and creating a feed-forward stimulatory mechanism
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additional information
GAF domains bind cAMP and thereby increase the adenylate cyclase activity 27fold, thus functioning as an autoactivating switch and creating a feed-forward stimulatory mechanism
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Achlorhydria
Adenylate cyclase in gastric mucosal biopsies from patients with achlorhydria. Stimulation by PGE2, histamine and gastrointestinal hormones.
Acidosis
Candidate human genetic polymorphisms and severe malaria in a Tanzanian population.
Acidosis
Effect of acidosis on PTH-dependent renal adenylate cyclase in phosphorus deprivation: role of G proteins.
Acidosis
Effect of acute metabolic acidosis on vasopressin-dependent cyclic AMP in rat kidney.
Acidosis
Effect of metabolic acidosis on the PTH receptor-adenylate cyclase system of canine kidney.
Acidosis
Hypercapnia Accelerates Adipogenesis: A Novel Role of High CO2 in Exacerbating Obesity.
Acidosis
The cardiac adrenergic system in ischaemia: differential role of acidosis and energy depletion.
Acquired Immunodeficiency Syndrome
The fine-structural distribution of G-protein receptor kinase 3, beta-arrestin-2, Ca2+/calmodulin-dependent protein kinase II and phosphodiesterase PDE1C2, and a Cl(-)-cotransporter in rodent olfactory epithelia.
Acromegaly
GH mRNA levels are elevated by forskolin but not GH releasing hormone in GHRH receptor-expressing MtT/S somatotroph cell line.
Acromegaly
Growth hormone releasing hormone-sensitive adenylate cyclase activity in growth hormone-producing pituitary adenoma: correlation to the response of plasma growth hormone to growth hormone releasing hormone in patients with acromegaly.
ACTH-Secreting Pituitary Adenoma
Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas.
ACTH-Secreting Pituitary Adenoma
Type I receptors for PACAP (a neuropeptide even more important than VIP?).
ACTH-Secreting Pituitary Adenoma
VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas.
Acute Kidney Injury
Diminished adenylate cyclase activity and aquaporin 2 expression in acute renal failure rats.
Acute Kidney Injury
The effect of gentamicin on antidiuretic hormone-stimulated osmotic water flow in the toad urinary bladder.
Adenocarcinoma
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Adenocarcinoma
Inactivation of the G alpha i2 and G alpha o genes by homologous recombination.
Adenocarcinoma
Production, analysis and bioactivity of recombinant vasoactive intestinal peptide analogs.
Adenocarcinoma
[Receptors for vasoactic intestinal peptide (VIP) in human colonic adenocarcinoma membranes: specific binding and stimulation of adenylate cyclase]
Adenocarcinoma of Lung
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Adenoma
Absence of activating mutations of the genes encoding the alpha-subunits of G11 and Gq in thyroid neoplasia.
Adenoma
Activation of adenyl cyclase in a pancreatic islet cell adenoma by glucagon and tolbutamide.
Adenoma
Adenylate cyclase activity and cyclic adenosine monophosphate levels in colon cancer lines and dermal fibroblasts and the effects of cholera toxin and epidermal growth factor.
Adenoma
Biological characteristics of adenomatous nodules, adenomas, and hyperfunctioning nodules as defined by adenylate cyclase activity and TSH receptors.
Adenoma
Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer.
Adenoma
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
Adenoma
Comparative study of cyclic AMP-generation system, steroid biosynthesis and lipid metabolism in vitro in ACTH responsive and unresponsive adrenal tumors.
Adenoma
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Adenoma
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Adenoma
Expression of adrenocorticotropin receptor gene in adrenocortical adenomas from patients with Cushing syndrome: possible contribution for the autonomous production of cortisol.
Adenoma
Growth hormone-releasing hexapeptide (GHRP-6) increases intracellular calcium concentrations in cultured cells from human pituitary adenomas of different types.
Adenoma
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Adenoma
Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine.
Adenoma
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Adenoma
Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas.
Adenoma
Resistance to somatostatin (SRIH) analog therapy in acromegaly. Re-evaluation of the correlation between the SRIH receptor status of the pituitary tumor and the in vivo inhibition of GH secretion in response to SRIH analog.
Adenoma
Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretions.
Adenoma
Somatostatin receptors, adenylate cyclase activity, and growth hormone (GH) response to octreotide in GH-secreting adenomas.
Adenoma
The adenylate cyclase-cyclic AMP-phosphodiesterase system in pathological human thyroid.
Adenoma
[Alterations in receptor status and signal transduction mechanisms in pituitary tumors]
Adenoma, Islet Cell
Activation of adenyl cyclase in a pancreatic islet cell adenoma by glucagon and tolbutamide.
Adenoma, Villous
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
adenosine deaminase deficiency
Lithium chloride induces partial responsiveness to LPS in nonresponder B cells.
adenylate cyclase deficiency
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
adenylate cyclase deficiency
Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
adenylate cyclase deficiency
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance.
adenylate cyclase deficiency
An enzymatic alteration secondary to adenylyl cyclase deficiency in the cr-1 (crisp) mutant of Neurospora crassa: nicotinamide adenine dinucleotide (phosphate) glycohydrolase overproduction.
adenylate cyclase deficiency
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
adenylate cyclase deficiency
Enzymatic alterations secondary to adenyl cyclase deficiency in the cr-1 (crisp) mutant of Neurospora crassa: anomalies of the beta-glucosidase system.
Adrenal Cortex Neoplasms
Abnormal hormone responses of an adrenocortical cancer adenyl cyclase.
Adrenal Cortex Neoplasms
Cholera toxin can ADP-ribosylate Gs as well as Gi in ACTH-unresponsive human adrenocortical cancer.
Adrenal Gland Neoplasms
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.
Adrenocortical Adenoma
Adenylate cyclase of human aldosterone-producing adrenocortical adenoma.
Adrenocortical Carcinoma
Dual regulation of adenylate cyclase and guanylate cyclase: alpha 2-adrenergic signal transduction in adrenocortical carcinoma cells.
Adrenocortical Carcinoma
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.
Adrenocortical Carcinoma
Ectopic beta-adrenergic receptors coupled to adenylate cyclase in human adrenocortical carcinomas.
Adrenocortical Carcinoma
Evidence for decreased activity of guanine nucleotide binding protein in adenylate cyclase of cell membranes in human ACTH-unresponsive adrenocortical carcinoma.
Adrenocortical Carcinoma
Inhibition of alpha 2-adrenergic receptor-mediated cyclic GMP formation by a phorbol ester, a protein kinase C activator.
Adrenocortical Carcinoma
Metabolic regulation and adenyl cyclase activity of adrenocortical carcinoma cultured cells.
Adrenocortical Carcinoma
Multiple specific hormone receptors in the adenylate cyclase of an adrenocortical carcinoma.
Airway Obstruction
Respiratory syncytial virus induces ?2-adrenergic receptor dysfunction in human airway smooth muscle cells.
Albuminuria
cAMP Signaling Prevents Podocyte Apoptosis via Activation of Protein Kinase A and Mitochondrial Fusion.
Altitude Sickness
Exposure to intermittent high altitude induces different changes in adenylyl cyclase activity in hearts of young and adult Wistar rats.
Altitude Sickness
[Effect of adaptation to high altitude hypoxia and cold on rat myocardial adenyl cyclase activity]
Alzheimer Disease
Acute desensitization of lymphocyte beta-adrenergic-stimulated adenylate cyclase in old age and Alzheimer's disease.
Alzheimer Disease
Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected.
Alzheimer Disease
Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease.
Alzheimer Disease
Age related decline in aluminum-activated human platelet adenylate cyclase: post-receptor changes in cyclic AMP second messenger signal amplification in normal aging and dementia of the Alzheimer type.
Alzheimer Disease
Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease.
Alzheimer Disease
Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain.
Alzheimer Disease
Basal and stimulated hippocampal adenylate cyclase activity in the experimentally lesioned rat entorhinal cortex.
Alzheimer Disease
Chronic but not acute intracerebroventricular administration of amyloid beta-peptide(25-35) decreases somatostatin content, adenylate cyclase activity, somatostatin-induced inhibition of adenylate cyclase activity, and adenylate cyclase I levels in the rat hippocampus.
Alzheimer Disease
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Alzheimer Disease
Decreased beta-adrenoceptor-stimulated adenylyl cyclase activity in lymphocytes from Alzheimer's disease patients.
Alzheimer Disease
Differential regulation of adenylyl cyclase in fibroblasts from sporadic and familial Alzheimer's disease cases with PS1 and APP mutations.
Alzheimer Disease
Effects of single and continuous administration of amyloid beta-peptide (25-35) on adenylyl cyclase activity and the somatostatinergic system in the rat frontal and parietal cortex.
Alzheimer Disease
G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies.
Alzheimer Disease
Hippocampal level of neural specific adenylyl cyclase type I is decreased in Alzheimer's disease.
Alzheimer Disease
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Alzheimer Disease
Increased accumulation of cAMP in cerebral microvessels in Alzheimer's disease.
Alzheimer Disease
Loss of stimulatory effect of guanosine triphosphate on [(35)S]GTPgammaS binding correlates with Alzheimer's disease neurofibrillary pathology in entorhinal cortex and CA1 hippocampal subfield.
Alzheimer Disease
Neurotransmitter receptor/G-protein mediated signal transduction in Alzheimer's disease brain.
Alzheimer Disease
Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease.
Alzheimer Disease
Quantitative autoradiography of [3H]forskolin binding sites in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Alzheimer Disease
Recovery of deficient cholinergic calcium signaling by adenosine in cultured rat cortical astrocytes.
Alzheimer Disease
Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes.
Alzheimer Disease
Regional distribution of somatostatin receptor binding and modulation of adenylyl cyclase activity in Alzheimer's disease brain.
Alzheimer Disease
Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain.
Alzheimer Disease
Regulation of GTPase and adenylate cyclase activity by amyloid beta-peptide and its fragments in rat brain tissue.
Alzheimer Disease
Somatostatin receptors and the modulation of adenylyl cyclase activity in Alzheimer's disease.
Alzheimer Disease
The effect of hydrogen peroxide upon beta-adrenoceptor density and function in C6 rat glioma cells.
Alzheimer Disease
The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques.
Amnesia
[Action of PMA (phorbol myristate acetate), scopolamine, propranolol, and oxotremorine on memorization of an active or passive avoidance test]
Amyloidosis
Protective Effects of Forskolin on Behavioral Deficits and Neuropathological Changes in a Mouse Model of Cerebral Amyloidosis.
Anaphylaxis
[Changes in the cyclic nucleotide system in experimental anaphylaxis and approaches to their correction]
Anemia
Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.
Anemia
Human red cell membrane adenylate cyclase in normal subjects and patients with hereditary spherocytosis, sickle cell disease and unidentified hemolytic anemias.
Anemia, Sickle Cell
Adenylyl Cyclase 9 Polymorphisms Reveal Potential Link to HDL Function and Cardiovascular Events in Multiple Pathologies: Potential Implications in Sickle Cell Disease.
Anemia, Sickle Cell
Association of adenylyl cyclase 6 rs3730070 polymorphism and hemolytic level in patients with sickle cell anemia.
Anemia, Sickle Cell
Human red cell membrane adenylate cyclase in normal subjects and patients with hereditary spherocytosis, sickle cell disease and unidentified hemolytic anemias.
Anosmia
Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice.
Anthrax
A Bacillus anthracis strain deleted for six proteases serves as an effective host for production of recombinant proteins.
Anthrax
A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol.
Anthrax
A deleted variant of Bacillus anthracis protective antigen is non-toxic and blocks anthrax toxin action in vivo.
Anthrax
A diverse set of single-domain antibodies (VHHs) against the anthrax toxin lethal and edema factors provides a basis for construction of a bispecific agent that protects against anthrax infection.
Anthrax
A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo.
Anthrax
A Heterodimer of a VHH (Variable Domains of Camelid Heavy Chain-only) Antibody That Inhibits Anthrax Toxin Cell Binding Linked to a VHH Antibody That Blocks Oligomer Formation Is Highly Protective in an Anthrax Spore Challenge Model.
Anthrax
A NEUTRALIZING MONOCLONAL ANTIBODY TO EDEMA TOXIN AND ITS EFFECT ON MURINE ANTHRAX.
Anthrax
A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.
Anthrax
A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor.
Anthrax
Accounting for ligand-bound metal ions in docking small molecules on adenylyl cyclase toxins.
Anthrax
Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin.
Anthrax
Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.
Anthrax
Anthrax edema factor, voltage-dependent binding to the protective antigen ion channel and comparison to LF binding.
Anthrax
Anthrax Edema Factor: An Ion-Adaptive Mechanism of Catalysis with Increased Transition-State Conformational Flexibility.
Anthrax
Anthrax edema toxin inhibits Nox1-mediated formation of reactive oxygen species by colon epithelial cells.
Anthrax
Anthrax edema toxin requires influx of calcium for inducing cyclic AMP toxicity in target cells.
Anthrax
Anthrax Lethal Factor (LF) Mediated Block of the Anthrax Protective Antigen (PA) Ion Channel: Effect of Ionic Strength and Voltage.
Anthrax
Anthrax lethal toxin induces ketotifen-sensitive intradermal vascular leakage in certain inbred mice.
Anthrax
Anthrax protective antigen: efficiency of translocation is independent of the number of ligands bound to the prepore.
Anthrax
Anthrax toxin blocks priming of neutrophils by lipopolysaccharide and by muramyl dipeptide.
Anthrax
Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously.
Anthrax
Anthrax toxin components stimulate chemotaxis of human polymorphonuclear neutrophils.
Anthrax
Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.
Anthrax
Anthrax toxin induces hemolysis: an indirect effect through polymorphonuclear cells.
Anthrax
Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Anthrax
Anthrax toxin protective antigen--insights into molecular switching from prepore to pore.
Anthrax
Anthrax toxin protective antigen: inhibition of channel function by chloroquine and related compounds and study of binding kinetics using the current noise analysis.
Anthrax
Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism.
Anthrax
Anthrax toxin-induced shock in rats is associated with pulmonary edema and hemorrhage.
Anthrax
Anthrax toxin-neutralizing antibody reconfigures the protective antigen heptamer into a supercomplex.
Anthrax
Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers.
Anthrax
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling.
Anthrax
Anthrax Vaccine Precipitated induces Edema Toxin-neutralizing, Edema Factor-specific antibodies in human recipients.
Anthrax
Antibodies to anthrax toxin in humans and guinea pigs and their relevance to protective immunity.
Anthrax
Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.
Anthrax
Asp 187 and Phe 190 residues in lethal factor are required for the expression of anthrax lethal toxin activity.
Anthrax
Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors.
Anthrax
ATP conformations and ion binding modes in the active site of anthrax edema factor: A computational analysis.
Anthrax
ATP Depletion Via Mitochondrial F1F0 Complex by Lethal Factor is an Early Event in B. Anthracis-Induced Sudden Cell Death.
Anthrax
Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells.
Anthrax
Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice.
Anthrax
Bacillus anthracis edema toxin inhibits hypoxic pulmonary vasoconstriction via edema factor and cAMP-mediated mechanisms in isolated perfused rat lungs.
Anthrax
Bacillus anthracis protective antigen kinetics in inhalation spore-challenged untreated or levofloxacin/ raxibacumab-treated New Zealand white rabbits.
Anthrax
Bacillus anthracis-derived edema toxin (ET) counter-regulates movement of neutrophils and macromolecules through the endothelial paracellular pathway.
Anthrax
Binding of N-terminal fragments of anthrax edema factor (EF(N)) and lethal factor (LF(N)) to the protective antigen pore.
Anthrax
Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
Anthrax
CD1d-dependent B-cell help by NK-like T cells leads to enhanced and sustained production of Bacillus anthracis lethal toxin-neutralizing antibodies.
Anthrax
Characterization of Protein-Protein Interfaces through a Protein Contact Network Approach.
Anthrax
Cloning and expression of the Bacillus anthracis protective antigen gene in Bacillus subtilis.
Anthrax
Cloning and expression of the calmodulin-sensitive Bacillus anthracis adenylate cyclase in Escherichia coli.
Anthrax
COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro.
Anthrax
Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin.
Anthrax
Cross-Reactivity of Anthrax and C2 Toxin: Protective Antigen Promotes the Uptake of Botulinum C2I Toxin into Human Endothelial Cells.
Anthrax
Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen.
Anthrax
Cys-Cys Cross-Linking Shows Contact between the N-Terminus of Lethal Factor and Phe427 of the Anthrax Toxin Pore.
Anthrax
Deletion mutants of protective antigen that inhibit anthrax toxin both in vitro and in vivo.
Anthrax
Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.
Anthrax
Detection of anthrax toxin by an ultrasensitive immunoassay using europium nanoparticles.
Anthrax
Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor.
Anthrax
Diminished but Not Abolished Effect of Two His351 Mutants of Anthrax Edema Factor in a Murine Model.
Anthrax
Discovery of a small molecule that inhibits the interaction of anthrax edema factor with its cellular activator, calmodulin.
Anthrax
Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.
Anthrax
Distinct interactions of 2'- and 3'-O-(N-methyl)anthraniloyl-isomers of ATP and GTP with the adenylyl cyclase toxin of Bacillus anthracis, edema factor.
Anthrax
Effect of nasal immunization with protective antigen of Bacillus anthracis on protective immune response against anthrax toxin.
Anthrax
Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor.
Anthrax
Electrostatic ratchet in the protective antigen channel promotes anthrax toxin translocation.
Anthrax
Emergence of anthrax edema toxin as a master manipulator of macrophage and B cell functions.
Anthrax
Evaluation of immune response to recombinant Bacillus anthracis LFD1-PA4 chimeric protein.
Anthrax
EVB Simulations of the Chemical Mechanism of ATP to cAMP Conversion by Anthrax Edema Factor.
Anthrax
Expression and purification of anthrax toxin protective antigen from Escherichia coli.
Anthrax
Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthrax.
Anthrax
Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen.
Anthrax
Fusion protein of Delta 27LFn and EFn has the potential as a novel anthrax toxin inhibitor.
Anthrax
Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells.
Anthrax
Gastric pH and Toxin Factors Modulate Infectivity and Disease Progression After Gastrointestinal Exposure to Bacillus anthracis.
Anthrax
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Anthrax
Hydrophobic residues Phe552, Phe554, Ile562, Leu566, and Ile574 are required for oligomerization of anthrax protective antigen.
Anthrax
Identification of a lead small-molecule inhibitor of anthrax lethal toxin by using fluorescence-based high-throughput screening.
Anthrax
Identification of a receptor-binding region within domain 4 of the protective antigen component of anthrax toxin.
Anthrax
Imaging the Cell Entry of the Anthrax Edema and Lethal toxins with Fluorescent Protein Chimeras.
Anthrax
Immunoelectrophoretic analysis, toxicity, and kinetics of in vitro production of the protective antigen and lethal factor components of Bacillus anthracis toxin.
Anthrax
Induction of cytotoxic T lymphocyte response against Mycobacterial antigen using domain I of anthrax edema factor as antigen delivery system.
Anthrax
Inhibition of anthrax toxins with a bispecific monoclonal antibody that cross reacts with edema factor as well as lethal factor of Bacillus anthracis.
Anthrax
Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.
Anthrax
Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.
Anthrax
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling.
Anthrax
Internalization of a Bacillus anthracis protective antigen-c-Myc fusion protein mediated by cell surface anti-c-Myc antibodies.
Anthrax
Involvement of residues 147VYYEIGK153 in binding of lethal factor to protective antigen of Bacillus anthracis.
Anthrax
Ion Conductance of the Stem of the Anthrax Toxin Channel during Lethal Factor Translocation.
Anthrax
Ion selectivity of the anthrax toxin channel and its effect on protein translocation.
Anthrax
Large-scale structural changes accompany binding of lethal factor to anthrax protective antigen: a cryo-electron microscopic study.
Anthrax
Lethal factor is not required for Bacillus anthracis virulence in guinea pigs and rabbits.
Anthrax
Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge.
Anthrax
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis.
Anthrax
Mapping the anthrax protective antigen binding site on the lethal and edema factors.
Anthrax
Mapping the epitopes of a neutralizing antibody fragment directed against the lethal factor of Bacillus anthracis and cross-reacting with the homologous edema factor.
Anthrax
Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen.
Anthrax
MD simulations of anthrax edema factor: calmodulin complexes with mutations in the edema factor "switch a" region and docking of 3'-deoxy ATP into the adenylyl cyclase active site of wild-type and mutant edema factor variants.
Anthrax
Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process.
Anthrax
Mechanism of reactant and product dissociation from the anthrax edema factor: A locally enhanced sampling and steered molecular dynamics study.
Anthrax
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway.
Anthrax
Model of the toxic complex of anthrax: responsive conformational changes in both the lethal factor and the protective antigen heptamer.
Anthrax
Modulation of the Bacillus anthracis secretome by the immune inhibitor A1 protease.
Anthrax
Molecular analysis of the interaction of anthrax adenylyl cyclase toxin, edema factor, with 2'(3')-O-(N-(methyl)anthraniloyl)-substituted purine and pyrimidine nucleotides.
Anthrax
Molecular motions as a drug target: mechanistic simulations of anthrax toxin edema factor function led to the discovery of novel allosteric inhibitors.
Anthrax
Murine innate immune response to virulent toxigenic and nontoxigenic Bacillus anthracis strains.
Anthrax
Murine macrophage transcriptional and functional responses to Bacillus anthracis edema toxin.
Anthrax
N-fragment of edema factor as a candidate antigen for immunization against anthrax.
Anthrax
Neutralizing activity of vaccine-induced antibodies to two Bacillus anthracis toxin components, lethal factor and edema factor.
Anthrax
Non-canonical effects of anthrax toxins on hem atop oiesis: implications for vaccine development.
Anthrax
Participation of residue F552 in domain III of the protective antigen in the biological activity of anthrax lethal toxin.
Anthrax
Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs.
Anthrax
pH-dependent permeabilization of the plasma membrane of mammalian cells by anthrax protective antigen.
Anthrax
Pharmacophore selection and redesign of non-nucleotide inhibitors of anthrax edema factor.
Anthrax
Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
Anthrax
Poly-gamma-d-glutamic acid and protective antigen conjugate vaccines induce functional antibodies against the protective antigen and capsule of Bacillus anthracis in guinea-pigs and rabbits.
Anthrax
Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding.
Anthrax
Preventing voltage-dependent gating of anthrax toxin channels using engineered disulfides.
Anthrax
Production and purification of Bacillus anthracis protective antigen from Escherichia coli.
Anthrax
Production of biologically active Bacillus anthracis edema factor in Escherichia coli.
Anthrax
Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino- or carboxy-terminus.
Anthrax
Protein translocation through anthrax toxin channels formed in planar lipid bilayers.
Anthrax
Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient.
Anthrax
Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently.
Anthrax
Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin.
Anthrax
Purification of anthrax edema factor from Escherichia coli and identification of residues required for binding to anthrax protective antigen.
Anthrax
Purified Bacillus anthracis lethal toxin complex formed in vitro and during infection exhibits functional and biological activity.
Anthrax
Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.
Anthrax
Rapid purification of recombinant anthrax-protective antigen under nondenaturing conditions.
Anthrax
Scalable purification of Bacillus anthracis protective antigen from Escherichia coli.
Anthrax
Secondary Structure Preferences of the Anthrax Toxin Protective Antigen Translocase.
Anthrax
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Anthrax
Small-Molecule Inhibitors of Lethal Factor Protease Activity Protect against Anthrax Infection.
Anthrax
Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.
Anthrax
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
Anthrax
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Anthrax
Structural basis of anthrax edema factor neutralization by a neutralizing antibody.
Anthrax
Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-Deficient Strains of Bacillus anthracis.
Anthrax
Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site.
Anthrax
Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry.
Anthrax
Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.
Anthrax
Study of immunization against anthrax with the purified recombinant protective antigen of Bacillus anthracis.
Anthrax
Synthesis of ?-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
Anthrax
The 2beta(2)-2beta(3) loop of anthrax protective antigen contains a dominant neutralizing epitope.
Anthrax
The anthrax protective antigen (PA63) bound conformation of a peptide inhibitor of the binding of lethal factor to PA63: as determined by trNOESY NMR and molecular modeling.
Anthrax
The carboxyl-terminal end of protective antigen is required for receptor binding and anthrax toxin activity.
Anthrax
The channel formed in planar lipid bilayers by the protective antigen component of anthrax toxin.
Anthrax
The CMG2 ELISA for evaluating inhibitors of the binding of anthrax toxin protective antigen to its receptor.
Anthrax
The early humoral immune response to Bacillus anthracis toxins in patients infected with cutaneous anthrax.
Anthrax
The HC fragment of tetanus toxin forms stable, concentration-dependent dimers via an intermolecular disulphide bond.
Anthrax
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen.
Anthrax
The Major Neutralizing Antibody Responses to Recombinant Anthrax Lethal Factor and Edema Factors Are Directed to Non-Cross-Reactive Epitopes.
Anthrax
The overlap of small molecule and protein binding sites within families of protein structures.
Anthrax
The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin.
Anthrax
Trapping a translocating protein within the anthrax toxin channel: implications for the secondary structure of permeating proteins.
Anthrax
Trp 346 and Leu 352 residues in protective antigen are required for the expression of anthrax lethal toxin activity.
Anthrax
Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.
Anthrax
[Efficient expression of anthrax edema factor in Escherichia coli and its single-step purification].
Anthrax
[Expression and analysis of biological activity of the recombination anthrax edema factor]
Anthrax
[The isolation and purification of the protective antigen and the edema factor from the culture filtrate of Bacillus anthracis STI-1]
Anthrax
[Toxin-neutralizing monoclonal antibodies to the different domains of anthrax protective antigen]
Aortic Coarctation
[The status of the adenylate cyclase system in rat myocardium in dystrophic degeneration]
Aortic Valve Disease
Effects of the H2-receptor agonist impromidine in human myocardium from patients with heart failure due to mitral and aortic valve disease.
Aortic Valve Insufficiency
Myocardial sympathetic denervation prevents chamber-specific alteration of beta-adrenergic transmembrane signaling in rabbits with heart failure.
Aortic Valve Stenosis
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
Aortic Valve Stenosis
[Beta-adrenergic receptivity and left ventricular hypertrophy caused by pressure overload in man]
Apraxias
Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease.
Arrhythmias, Cardiac
Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction.
Arrhythmias, Cardiac
Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice.
Arteriosclerosis
[Adenyl cyclase activity in the tissues and excretion of cyclic adenosine monophosphate in experimental arteriosclerosis]
Arthritis
Adenyl cyclase activity in lymphocytes stimulated with immunologically specific and nonspecific stimuli.
Asthenozoospermia
ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria.
Asthenozoospermia
Biochemical correlates of asthenozoospermia: a lesion at the level of the sperm adenylyl cyclase.
Asthma
?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.
Asthma
Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children.
Asthma
Allergen challenge primes for IL-5 mRNA production and abrogates beta-adrenergic function in peripheral blood T lymphocytes from asthmatics.
Asthma
Defect in potentiation of adenylyl cyclase correlates with bronchial hyperreactivity.
Asthma
Desensitization of the adenylyl cyclase system in peripheral blood mononuclear cells from patients with asthma three hours after allergen challenge.
Asthma
Effects of salmeterol on muscarinic inhibition of adenylyl cyclase in bovine trachealis cells.
Asthma
Experiments on the role of virus infections in the pathogenesis of bronchial asthma. The role of innate or acquired insufficiency or ergotropic adaptation in the mechanism of genesis of bronchial asthma.
Asthma
Hormone-sensitive adenylate cyclase system in lymphocytes from asthmatic patients: possible defects at the postreceptor sites.
Asthma
Lack of coupling of muscarinic receptors to phosphoinositide metabolism and adenylyl cyclase in human lymphocytes and polymorphonuclear leukocytes: studies in healthy subjects and allergic asthmatic patients.
Asthma
Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.
Asthma
Oral macrophage-like cells play a key role in tolerance induction following sublingual immunotherapy of asthmatic mice.
Asthma
Peripheral blood T lymphocytes from asthmatic patients are primed for enhanced expression of interleukin (IL)-4 and IL-5 mRNA: associations with lung function and serum IgE.
Asthma
Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma.
Asthma
Pituitary adenylate cyclase-activating peptide receptor 1 mediates anti-inflammatory effects in allergic airway inflammation in mice.
Asthma
Reduced adenylyl cyclase activation with no decrease in beta-adrenergic receptors in basenji greyhound leukocytes: relevance to beta-adrenergic responses in airway smooth muscle.
Asthma
Reduced responsiveness of adenylate cyclase in alveolar macrophages from patients with asthma.
Asthma
Regulation of beta 2-adrenergic receptors and the implications for bronchial asthma: an update.
Asthma
Regulation of the beta-receptor-adenylate cyclase system in lymphocytes of allergic patients with asthma: possible role for protein kinase C in allergen-induced nonspecific refractoriness of adenylate cyclase.
Asthma
Relationship between nonspecific bronchial responsiveness to methacholine and peripheral mononuclear leukocyte beta-adrenergic receptor function in young drug-naive subjects.
Asthma
Response of leucocyte adenyl cyclase to isoprenaline and effect of alpha-blocking drugs in extrinsic bronchial asthma.
Asthma
Salmeterol attenuates the inflammatory response in asthma and decreases the pro-inflammatory cytokine secretion of dendritic cells.
Asthma
Salmeterol-induced desensitization, internalization and phosphorylation of the human beta2-adrenoceptor.
Asthma
The beta-adrenergic system and allergic bronchial asthma: changes in lymphocyte beta-adrenergic receptor number and adenylate cyclase activity after an allergen-induced asthmatic attack.
Asthma
The relationship of leucocyte adenyl cyclase activity and airways response to beta blockade and allergen challenge in extrinsic asthma.
Asthma
The role of adenylyl cyclase isoform 6 in ?-adrenoceptor signalling in murine airways.
Asthma
The role of phospholipase in reduced beta-adrenergic responsiveness in experimental asthma.
Asthma
[Adrenergic blockade theory on the bronchial asthma, especially emphasizing adenyl cyclase activity (author's transl)]
Asthma
[Interrelation between changes of adenylate cyclase and levels of several hormones in children with bronchial asthma]
Asthma
[Role of adenylate cyclase system in pathogenesis of various types of occupational bronchial asthma]
Astrocytoma
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
Astrocytoma
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells.
Astrocytoma
Adenosine inhibits histamine-induced phosphoinositide hydrolysis mediated via pertussis toxin-sensitive G protein in human astrocytoma cells.
Astrocytoma
Agonists and phorbol esters desensitize beta-adrenergic receptors by different mechanisms.
Astrocytoma
An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors.
Astrocytoma
Bicarbonate induces sensitization of cyclic AMP accumulation by intact 1321N1 human astrocytoma cells.
Astrocytoma
Bradykinin inhibits cyclic AMP accumulation in D384-human astrocytoma cells via a calcium-dependent inhibition of adenylyl cyclase.
Astrocytoma
Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors.
Astrocytoma
Catecholamine-induced desensitization involves an uncoupling of beta-adrenergic receptors and adenylate cyclase.
Astrocytoma
Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells.
Astrocytoma
Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase.
Astrocytoma
D-1 dopaminergic and beta-adrenergic stimulation of adenylate cyclase in a clone derived from the human astrocytoma cell line G-CCM.
Astrocytoma
Differential coupling of the human P2Y(11) receptor to phospholipase C and adenylyl cyclase.
Astrocytoma
Differential expression of components of the adenylate cyclase system during growth of astrocytoma cells in culture.
Astrocytoma
Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells.
Astrocytoma
Endogenous GTP and the regulation of epinephrine stimulation of adenylate cyclase.
Astrocytoma
Expression of rat mRNA coding for hormone-stimulated adenylate cyclase in Xenopus oocytes.
Astrocytoma
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
Astrocytoma
G?(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.
Astrocytoma
Inhibition of beta(2)-adrenergic and muscarinic cholinergic receptor endocytosis after depletion of phosphatidylinositol bisphosphate.
Astrocytoma
Isolation of adenylate cyclase-enriched membranes from mammalian cells using concanavalin A.
Astrocytoma
Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors.
Astrocytoma
Maintenance of whole cell isoproterenol and forskolin responsiveness in adenylate cyclase of permeabilized cells.
Astrocytoma
Mechanisms of alpha-Sialosyl cholesterol action to suppress both cyclic AMP production and DNA synthesis of rat glial cells.
Astrocytoma
Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.
Astrocytoma
Mepacrine treatment prevents immobilization-induced desensitization of beta-adrenergic receptors in rat hypothalamus and brain stem.
Astrocytoma
Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C.
Astrocytoma
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors.
Astrocytoma
Phospholipid methylation: a possible mechanism of signal transduction across biomembranes.
Astrocytoma
Regulation of adenosine 3':5'-monophosphate content of human astrocytoma cells: desensitization to catecholamines and prostaglandins.
Astrocytoma
Role of beta-adrenergic receptors in catecholamine-induced desensitization of adenylate cyclase in human astrocytoma cells.
Astrocytoma
Selective ?2 adrenergic agonist increases Cx43 and miR-451 expression via cAMP-Epac.
Astrocytoma
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family.
Astrocytoma
The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site.
Astrocytoma
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
Ataxia
Involvement of kappa-opioids in the mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination.
Ataxia
Mouse cerebellar adenosinergic modulation of ethanol-induced motor incoordination: possible involvement of cAMP.
Ataxia
Rat striatal adenosinergic modulation of ethanol-induced motor impairment: possible role of striatal cyclic AMP.
Ataxia
Sustained antagonism of acute ethanol-induced ataxia following microinfusion of cyclic AMP and cpt-cAMP in the mouse cerebellum.
Atherosclerosis
Adenosine inhibitory effect on enhanced growth of aortic smooth muscle cells from streptozotocin-induced diabetic rats.
Atherosclerosis
Adenylate Cyclase Type 9 (ADCY9) Inactivation Protects from Atherosclerosis Only in the Absence of Cholesteryl Ester Transfer Protein (CETP).
Atherosclerosis
Effects of dietary fluoride and magnesium supplements on cyclic adenosine monophosphate (cAMP), calcium and magnesium levels in aorta of genetically hypercholesterolaemic RICO rats.
Atherosclerosis
Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis.
Atherosclerosis
The Notch pathway attenuates interleukin 1? (IL1?)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation.
Atherosclerosis
[Effect of cortisol on adenylate cyclase and 3',5'-AMP phosphodiesterase activity and 3',5'-AMP concentration in tissues and biological fluids in experimental atherosclerosis]
Azotemia
The effect of hemodialysis on levels of cyclic nucleotide-associated hormones in patients with chronic renal failure.
Bacterial Infections
Constitutive expression of protective antigen gene of Bacillus anthracis in Escherichia coli.
Bone Diseases
A Signature of Circulating miRNAs Associated With Fibrous Dysplasia of Bone: the mirDys Study.
Bone Diseases, Metabolic
The effect of monocyclic and bicyclic analogs of human parathyroid hormone (hPTH)-(1-31)NH2 on bone formation and mechanical strength in ovariectomized rats.
Bone Neoplasms
Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model.
Bone Resorption
A noncyclical analog of salmon calcitonin (N alpha-propionyl Di-Ala1,7,des-Leu19 sCT) retains full potency without inducing anorexia in rats.
Bone Resorption
Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.
Bone Resorption
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
Bone Resorption
Adenylate cyclase stimulating activity immunologically similar to parathyroid hormone-related peptide can be extracted from fetal rat long bones.
Bone Resorption
Alterations in serum and urine parameters reflecting bone turnover in uremic patients during treatment with 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3.
Bone Resorption
Bone collagen synthesis in vitro: structure/activity relations among parathyroid hormone fragments and analogs.
Bone Resorption
Bone resorption induced by A23187 is abolished by indomethacin: implications for second messenger utilised by parathyroid hormone.
Bone Resorption
Calcitonin-like effects of forskolin and choleratoxin on surface area and motility of isolated rabbit osteoclasts.
Bone Resorption
Characterization of a K26Q site-directed mutant of human parathyroid hormone expressed in yeast.
Bone Resorption
Cholera toxin-stimulated bone resorption in cultured mouse calvarial bones not inhibited by calcitonin: a possible interaction at the stimulatory G protein.
Bone Resorption
Comparison of the effects of a potent synthetic analog of bovine parathyroid hormone with native bPTH-(1-84) and synthetic bPTH-(1-34) on bone resorption and collagen synthesis.
Bone Resorption
Delayed stimulation of bone resorption in vitro by phosphodiesterase inhibitors requires the presence of adenylate cyclase stimulation.
Bone Resorption
Effect of diphosphonates on adenosine 3':5'-cyclic monophosphate in mouse calvaria after stimulation by parathyroid hormone in vitro.
Bone Resorption
Effects of atrial natriuretic factor on cyclic nucleotides, bone resorption, collagen and deoxyribonucleic acid synthesis, and prostaglandin E2 production in fetal rat bone cultures.
Bone Resorption
Effects of cholera toxin on cyclic AMP accumulation and bone resorption in cultured mouse calvaria.
Bone Resorption
Effects of selective prostaglandin EP2 and EP4 receptor agonists on bone resorption and formation in fetal rat organ cultures.
Bone Resorption
Effects of transforming growth factor-alpha on parathyroid hormone- and parathyroid hormone-related protein-mediated bone resorption and adenylate cyclase stimulation in vitro.
Bone Resorption
Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy.
Bone Resorption
Forskolin has both stimulatory and inhibitory effects on bone resorption in fetal rat long bone cultures.
Bone Resorption
Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro.
Bone Resorption
Leukotriene B4 increases intracellular calcium concentration and phosphoinositide metabolism in mouse osteoblasts via cyclic adenosine 3',5'-monophosphate-independent pathways.
Bone Resorption
Parathyroid hormone-induced calcium efflux from cultured bone is mediated by protein kinase C translocation.
Bone Resorption
Phosphorylation of the human calcitonin receptor by multiple kinases is localized to the C-terminus.
Bone Resorption
Role of phosphodiesterase in the parathormone-stimulated adenosine 3',5'-monophosphate response in bone cell populations enriched in osteoclasts and osteoblasts.
Bone Resorption
Selective anabolic effects of muteins of mid-region PTH fragments on skeletal tissues of prepubertal rats.
Bone Resorption
The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone.
Bone Resorption
The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays.
Bone Resorption
Use of forskolin to study the relationship between cyclic AMP formation and bone resorption in vitro.
Bordetella Infections
The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis.
Brachydactyly
Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy.
Bradycardia
Adjustments in cholinergic, adrenergic and purinergic control of cardiovascular function in snapping turtle embryos (Chelydra serpentina) incubated in chronic hypoxia.
Brain Death
Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death.
Brain Death
Beta-adrenergic receptor antagonism preserves myocardial function after brain death in a porcine model.
Brain Death
Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death.
Brain Death
Role of the beta-adrenergic receptor kinase in myocardial dysfunction after brain death.
Brain Death
Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death.
Brain Diseases
Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.
Brain Edema
Enzyme histochemistry of rat interfascicular oligodendroglia, with special reference to 5'-nucleotidase.
Brain Edema
Histamine H2-receptors participate in the formation of brain edema induced by kainic acid in rat thalamus.
Brain Edema
[Experimental study of pituitary adenylate cyclase activating polypeptide on relieving brain edema induced by ischemia in rats].
Brain Injuries
Cannabinoid receptor activation and elevated cyclic AMP reduce glutamate neurotoxicity.
Brain Injuries
Regulation of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: comparison with brain-derived neurotrophic factor and the induction of neuronal cell death.
Brain Injuries, Traumatic
Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury.
Brain Injuries, Traumatic
Effects of pituitary adenylate cyclase activating polypeptide on CD4(+)/CD8(+) T cell levels after traumatic brain injury in a rat model.
Brain Injuries, Traumatic
Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration.
Brain Injuries, Traumatic
Plasma pituitary adenylate cyclase-activating polypeptide concentrations and mortality after acute spontaneous basal ganglia hemorrhage.
Brain Injuries, Traumatic
Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats.
Brain Injuries, Traumatic
Regulation of pituitary adenylate cyclase activating polypeptide and its receptor type 1 after traumatic brain injury: comparison with brain-derived neurotrophic factor and the induction of neuronal cell death.
Brain Ischemia
Adenylate cyclase activity and motor behavior following cerebral ischemia in the unanesthetized gerbil.
Brain Ischemia
Alteration of second messengers during acute cerebral ischemia - adenylate cyclase, cyclic AMP-dependent protein kinase, and cyclic AMP response element binding protein.
Brain Ischemia
Autoradiographic analysis on second-messenger systems and local cerebral blood flow in ischemic gerbil brain.
Brain Ischemia
Enhanced maximal binding capacity (Bmax) of second messenger ligand in the acute phase of cerebral ischemia--direct visualization by digital image analysis.
Brain Ischemia
Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration.
Brain Ischemia
Impairment of adenylyl cyclase and of spatial memory function after microsphere embolism in rats.
Brain Ischemia
Pituitary adenylate cyclase activating polypeptide in the retina: focus on the retinoprotective effects.
Brain Ischemia
Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats.
Brain Ischemia
Selective reduction in type I adenylyl cyclase after microsphere embolism in rat brain.
Brain Ischemia
Spatial and temporal distribution of pituitary adenylate cyclase activating polypeptide in gerbil global cerebral ischemia.
Brain Ischemia
[Adenylate cyclase activity and cyclic AMP content in brain tissue of dogs during clinical death and in the post-resuscitation period]
Brain Neoplasms
Cerebral tumours induced by ENU; changes of adenylate cyclase activity in the tumour latency time.
Brain Neoplasms
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
Brain Neoplasms
Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk.
Breast Neoplasms
1,25 Dihydroxyvitamin D3 modulates adenylate cyclase activity of the human breast cancer cell line T47D through increased synthesis of Gs.
Breast Neoplasms
A new in vitro bioassay for human calcitonin: validation and comparison to the rat hypocalcemia bioassay.
Breast Neoplasms
Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells.
Breast Neoplasms
An adenylate cyclase of brain reflects propensity for breast cancer in mice.
Breast Neoplasms
Behaviour of adenyl cyclase in mammary gland of mice subsceptible and resistant to breast cancer.
Breast Neoplasms
Biological activities and receptor interactions of des-Leu16 salmon and des-Phe16 human calcitonin.
Breast Neoplasms
Breast cancer cell response to calcitonin: modulation by growth-regulating agents.
Breast Neoplasms
Calcitonin and 1,25-dihydroxyvitamin D3 receptors in human breast cancer cell lines.
Breast Neoplasms
Calcitonin binding and degradation by two cultured human breast cancer cell lines (MCF 7 and T 47D).
Breast Neoplasms
Calcitonin induction of a persistent activated state of adenylate cyclase in human breast cancer cells (T 47D).
Breast Neoplasms
Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca2+ Release and Cyclic AMP.
Breast Neoplasms
Characterization of a receptor subtype-selective lysophosphatidic acid mimetic.
Breast Neoplasms
Characterization of normal breast epithelial cells in primary cultures: differentiation and growth factor receptors studies.
Breast Neoplasms
Covalent cross-linking of a photoactive derivative of calcitonin to human breast cancer cell receptors.
Breast Neoplasms
Different effects of adenylyl cyclase activators and phosphodiesterases inhibitors on cervical cancer (HeLa) and breast cancer (MCF-7) cells proliferation.
Breast Neoplasms
Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells.
Breast Neoplasms
Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.
Breast Neoplasms
Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line.
Breast Neoplasms
Estrogen signaling characteristics of Atlantic croaker G protein-coupled receptor 30 (GPR30) and evidence it is involved in maintenance of oocyte meiotic arrest.
Breast Neoplasms
Growth factor-induced transcription via the serum response element is inhibited by cyclic adenosine 3',5'-monophosphate in MCF-7 breast cancer cells.
Breast Neoplasms
Hormonal modulation of plasminogen activator: an approach to prediction of human breast tumor responsiveness.
Breast Neoplasms
Interaction of adrenomedullin with calcitonin receptor in cultured human breast cancer cells, T 47D.
Breast Neoplasms
Potentiation of glycine responses by dideoxyforskolin and tamoxifen in rat spinal neurons.
Breast Neoplasms
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation.
Bronchial Hyperreactivity
Defect in potentiation of adenylyl cyclase correlates with bronchial hyperreactivity.
Bronchial Spasm
Membrane IgE and adenyl cyclase activity in the dynamics of bronchospasm. Ketotifen as a blocker of antigen action.
Bronchiolitis
Nonspecific refractoriness to adenylyl cyclase stimulation in alveolar macrophages from infants with recurrent bronchiolitis.
Bulbo-Spinal Atrophy, X-Linked
Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy.
Byssinosis
Byssinosis: role of polymer length on the effect of tannin on the airway beta-adrenergic receptor.
Camurati-Engelmann Syndrome
The new bone biology: pathologic, molecular, and clinical correlates.
Carcinogenesis
Alterations in hormone responsiveness of hepatic adenylate cyclase during ontogenesis and oncogenesis.
Carcinogenesis
Anticarcinogenic effect of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate on 7,12-dimethylbenz(a)anthracene mammary tumor induction in the rat and its relationship to cyclic adenosine 3':5'-monophosphate metabolism and protein kinase.
Carcinogenesis
Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk.
Carcinogenesis
Methylation of Cervical Neoplastic Cells Infected With Human Papillomavirus 16.
Carcinogenesis
The adenyl cyclase system and carcinogenesis: decreased responsiveness of mouse epidermis to isoproterenol after 3,4-benzpyrene treatment.
Carcinogenesis
Tumorigenesis-related key genes in adolescents and young adults with HR(+)/HER2(-) breast cancer.
Carcinogenesis
[Adenylate cyclase activity in capillary walls and in hairy cells during experimental carcinogenesis]
Carcinogenesis
[Disordered regulation of cell membrane adenyl cyclase and guanyl cyclase activity as a possible factor in carcinogenesis]
Carcinogenesis
[Interrelation between the phospholipid composition of rat liver plasma membranes and adenylate cyclase activity in the early stages of liver carcinogenesis induced by nitrosodiethylamine]
Carcinogenesis
[Statement of the possible role of adenyl cyclase system and cyclic adenosine monophosphate in the carcinogenesis process]
Carcinoid Tumor
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
Carcinoid Tumor
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
Carcinoma
Absence of activating mutations of the genes encoding the alpha-subunits of G11 and Gq in thyroid neoplasia.
Carcinoma
Adenylate cyclase activity of renal cortical carcinoma and its relation to histology and ultrastructure.
Carcinoma
Adenylate cyclase and protein phosphokinase activities in human thyroid. Comparison of normal glands, hyperfunctional nodules and carcinomas.
Carcinoma
Adenylate cyclase, cyclic adenosin 3':5'-monophosphate phosphodiesterase, and regression of Walker 256 mammary carcinoma.
Carcinoma
Characterization of beta-adrenergic receptor linked to adenylate cyclase in a human cancer cell line (COLO 16).
Carcinoma
Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.
Carcinoma
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.
Carcinoma
Ectopic beta-adrenergic receptors coupled to adenylate cyclase in human adrenocortical carcinomas.
Carcinoma
Effect of estradiol and progesterone on the adenylate cyclase activity in grafts of 3-methylcholanthrene induced carcinomas in the mouse uterine cervix.
Carcinoma
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Carcinoma
Effects of thyroid-stimulating hormone on human thyroid carcinoma and adjacent normal tissue.
Carcinoma
Enhanced stimulatory adenylyl cyclase signaling during opioid dependence is associated with a reduction in palmitoylated Gs alpha.
Carcinoma
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Carcinoma
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system.
Carcinoma
Estradiol up-regulates the stimulatory GTP-binding protein expression in the MCF-7 human mammary carcinoma cell line.
Carcinoma
Evidence for the presence of both D-1 and D-2 dopamine receptors in human esophagus.
Carcinoma
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Carcinoma
Forskolin increases the expression of the pancreatic tumor antigen, Nd2, and uptake of Nd2 antibody.
Carcinoma
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Carcinoma
Histochemical profile of mouse hepatocellular adenomas and carcinomas induced by a single dose of diethylnitrosamine.
Carcinoma
Human thyroid cancer: membrane thyrotropin binding and adenylate cyclase activity.
Carcinoma
Induction of adenylate cyclase in a mammary carcinoma cell line by human corticosteroid-binding globulin.
Carcinoma
Interaction of vasoactive intestinal peptide with a cell line (HeLa) derived from human carcinoma of the cervix: binding to specific sites and stimulation of adenylate cyclase.
Carcinoma
Loss of platelet-derived growth factor-stimulated phospholipase activity in NIH-3T3 cells expressing the EJ-ras oncogene.
Carcinoma
Modulation of cis-diamminedichloroplatinum(II) accumulation and sensitivity by forskolin and 3-isobutyl-1-methylxanthine in sensitive and resistant human ovarian carcinoma cells.
Carcinoma
Modulation of the beta-adrenergic receptor-coupled adenylate cyclase by chemical inducers of differentiation: effects on beta receptors and the inhibitory regulatory protein Gi.
Carcinoma
PACAP and VIP stimulate enzyme secretion in rat pancreatic acini via interaction with VIP/PACAP-2 receptors: additive augmentation of CCK/carbachol-induced enzyme release.
Carcinoma
PACAP stimulates transcription of c-Fos and c-Jun and activates the AP-1 transcription factor in rat pancreatic carcinoma cells.
Carcinoma
PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line.
Carcinoma
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Carcinoma
Synergistic activation of non-rectifying small-conductance chloride channels by forskolin and phorbol esters in cell-attached patches of the human colon carcinoma cell line HT-29cl.19A.
Carcinoma
The adenylate cyclase-cyclic AMP-phosphodiesterase system in pathological human thyroid.
Carcinoma
Thyrotropin (TSH) receptor and adenylate cyclase activity in human thyroid tumors: absence of high affinity receptor and loss of TSH responsiveness in undifferentiated thyroid carcinoma.
Carcinoma
Transformation of BALB/3T3 cells with EJ/T24/H-ras oncogene inhibits adenylate cyclase response to beta-adrenergic agonist while increases muscarinic receptor dependent hydrolysis of inositol lipids.
Carcinoma
Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells.
Carcinoma
[Biochemical differences in the tumor cells of 5-fluorouracil-sensitive and -resistant strains of Ehrlich ascitic carcinoma]
Carcinoma
[Effect of hypolipidemic preparations on basal and stimulated adenylate cyclase activity in tumor cells]
Carcinoma
[Effects of thyroid-stimulating hormone on adenylate cyclase of well differentiated human carcinoma and adjacent normal tissues]
Carcinoma, Bronchogenic
Calcitonin-responsive adenylate cyclase in a calcitonin-producing human cancer cell line.
Carcinoma, Ehrlich Tumor
Anti-microtubular agents as inhibitors of desensitization to catecholamine stimulation of adenylate cyclase in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Difference between magnesium and manganese ions in modification of effect of catecholamine on adenylate cyclase system in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
[adenylate cyclase system in Ehrlich ascites tumor cells sensitive and resistant to 5-fluorouracil]
Carcinoma, Embryonal
Adenylyl cyclase activity and gene expression during mesodermal differentiation of the P19 embryonal carcinoma cells.
Carcinoma, Embryonal
Alterations in calcitonin and parathyroid hormone responsiveness of adenylate cyclase in F9 embryonal carcinoma cells treated with retinoic acid and dibutyryl cyclic AMP.
Carcinoma, Embryonal
Altered activation by calcitonin and inhibition by somatostatin of human embryonal carcinoma cell adenylate cyclase with retinoic acid-induced differentiation.
Carcinoma, Embryonal
Altered hormonal responses: markers for embryonal and embryonic carcinoma stem cells and their differentiated derivatives.
Carcinoma, Embryonal
Calcitonin-responsive adenylate cyclase in cultured F9 embryonal carcinoma cells.
Carcinoma, Embryonal
Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells.
Carcinoma, Embryonal
Production of immunoreactive calcitonin and parathyroid hormone by embryonal carcinoma cells: alteration with retinoic acid-induced differentiation.
Carcinoma, Embryonal
The expression of retinoic acid receptors in cultured human endometrial stromal cells and effects of retinoic acid.
Carcinoma, Hepatocellular
Adenyl cyclase activity in Morris hepatomas 7777, 7794A, and 9618A.
Carcinoma, Hepatocellular
Adenylate cyclase activity in plasma membranes of chicken liver and of Mc-29 virus induced hepatoma.
Carcinoma, Hepatocellular
Altered adrenergic response and specificity of the receptors in rat ascites hepatoma AH130.
Carcinoma, Hepatocellular
Anomalous adenosine cyclic 3':5'-monophosphate responses to glucagon in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Bisecting GlcNAc structures act as negative sorting signals for cell surface glycoproteins in forskolin-treated rat hepatoma cells.
Carcinoma, Hepatocellular
Changes in alpha-1 and beta-2 adrenoceptor density in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Changes of adenylate cyclase activity in AH-130 ascites hepatoma of Yoshida induced by enrichment with fatty acids.
Carcinoma, Hepatocellular
Comparative adenylate cyclase activities in homogenate and plasma membrane fractions of Morris hepatoma 5123tc (h).
Carcinoma, Hepatocellular
Comparison of the epinephrine-mediated activation of adenylate cyclase in plasma membranes from liver and ascites hepatomas of rats.
Carcinoma, Hepatocellular
Coordinate regulation of adenylate cyclase, protein kinase, and specific enzyme synthesis by cholera toxin in hormonally unresponsive hepatoma cells.
Carcinoma, Hepatocellular
Cyclic AMP signalling pathway and cellular proliferation: induction of CREM during liver regeneration.
Carcinoma, Hepatocellular
Cytochemical localization of adenyl cyclase in isoproterenol stimulated hepatoma ascites cells.
Carcinoma, Hepatocellular
Effect of mitomycin C on the activation of adenylate cyclase in rat ascites hepatoma AH130 cells.
Carcinoma, Hepatocellular
Effect of prostaglandins on adenylate cyclase activities in membranes from liver and transplantable hepatomas.
Carcinoma, Hepatocellular
Effect of sodium fluoride on the epinephrine response of liver and hepatoma adenyl cyclase.
Carcinoma, Hepatocellular
Enzymatic, biophysical and ultrastructural changes of plasma membranes in chemical-induced rat hepatoma.
Carcinoma, Hepatocellular
Forskolin inhibits the Gs-stimulated adenylate cyclase in rat ascites hepatoma AH66F cells.
Carcinoma, Hepatocellular
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.
Carcinoma, Hepatocellular
Glucagon and epinephrine activation of adenylate cyclase and glucagon binding in Morris hepatomas.
Carcinoma, Hepatocellular
Glucagon and prostaglandin E1 stimulation of cyclic adenosine 3', 5'-monophosphate levels and adenylate cyclase activity in benign hyperplastic nodules and malignant hepatomas of ethionine-treated rats.
Carcinoma, Hepatocellular
Increased guanylate cyclase activity and guanosine 3',5'-monophosphate content in ethionine-induced hepatomas.
Carcinoma, Hepatocellular
Inositolphosphoglycans possibly mediate the effects of glucagon-like peptide-1(7-36)amide on rat liver and adipose tissue.
Carcinoma, Hepatocellular
Membrane receptor function and the loss of glucagon-stimulated adenylate cyclase activity in hepatomas.
Carcinoma, Hepatocellular
Prostaglandin receptor-adenylate cyclase system in plasma membranes of rat liver and ascites hepatomas, and the effect of GTP upon it.
Carcinoma, Hepatocellular
Regulation of adenyl cyclase in hepatomas of different growth rates.
Carcinoma, Hepatocellular
Regulation of the adenylate cyclase system in transplantable hepatomas.
Carcinoma, Hepatocellular
Sequential alterations in the hepatic content and metabolism of cyclic AMP and cyclic GMP induced by DL-ethionine: evidence for malignant transformation of liver with a sustained increase in cyclic AMP.
Carcinoma, Hepatocellular
Soluble and membrane-bound adenylate cyclase activity in Yoshida ascites hepatoma.
Carcinoma, Hepatocellular
Stimulatory and inhibitory effects of forskolin on adenylate cyclase in rat normal hepatocytes and hepatoma cells.
Carcinoma, Hepatocellular
Studies of cAMP metabolism in cultured hepatoma cells: presence of functional adenylate cyclase despite low cAMP content and lack of hormonal responsiveness.
Carcinoma, Hepatocellular
Studies on plasma membranes. XIV. Adenyl cyclase in plasma membranes isolated from rat and mouse livers and hepatomas, and its hormone sensitivity.
Carcinoma, Hepatocellular
Studies on responsiveness of hepatoma cells to catecholamines. I. Lack of beta-adrenergic responsiveness in rat ascites hepatoma AH13 cells.
Carcinoma, Hepatocellular
Studies on responsiveness of hepatoma cells to catecholamines. VI. Characteristics of adrenoceptors and adenylate cyclase response in rat ascites hepatoma cells and human hepatoma cells.
Carcinoma, Hepatocellular
Temperature effects on the modulation of adenylate cyclases from rat liver and Morris hepatomas.
Carcinoma, Hepatocellular
The action of mitomycin C on the induction of cyclic AMP phosphodiesterase and the development of desensitization of adenylate cyclase by isoproterenol in rat ascites hepatoma AH130 cells.
Carcinoma, Hepatocellular
The role of cAMP-MAPK signalling in the regulation of human hepatocellular carcinoma growth in vitro.
Carcinoma, Hepatocellular
[Activation of adenylate cyclase of rat ascites hepatoma by catecholamines and antagonism of beta-adrenergic blocking agents (author's transl)]
Carcinoma, Hepatocellular
[Concentration and metabolism of cyclic AMP during the early stages of hepatoma 22a growth]
Carcinoma, Hepatocellular
[Concentration of cyclic nucleotides, activity of adenylate cyclase, 3',5'-AMP phosphodiesterase and guanylate cyclase in plasma membranes from liver and hepatomas of different degrees of malignancy]
Carcinoma, Hepatocellular
[Effect of 10-hydroxycamptothecin on adenylate cyclase activity in murine hepatoma cells]
Carcinoma, Hepatocellular
[Some features of cyclic adenosine monophosphate metabolism in mouse liver and hepatoma 22]
Carcinoma, Hepatocellular
[The role of the components of the cyclic nucleotide system in N-nitrosodiethylamine-induced hepatic carcinogenesis in rats]
Carcinoma, Medullary
Human thyroid cancer: membrane thyrotropin binding and adenylate cyclase activity.
Carcinoma, Medullary
Pituitary adenylate cyclase-activating polypeptide receptors of types I and II and glucagon-like peptide-I receptors are expressed in the rat medullary carcinoma of the thyroid cell line 6/23.
Carcinoma, Non-Small-Cell Lung
Pituitary adenylate cyclase activating peptide receptors regulate the growth of non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
The G Protein-Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3.
Carcinoma, Papillary
Cell kinetics, DNA content and TSH receptor-adenylate cyclase system in differentiated thyroid cancer.
Carcinoma, Papillary
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
Carcinoma, Papillary
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Carcinoma, Renal Cell
Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor.
Carcinoma, Renal Cell
Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity.
Carcinoma, Small Cell
Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line.
Carcinoma, Squamous Cell
Characterization of beta-adrenergic receptor linked to adenylate cyclase in a human cancer cell line (COLO 16).
Carcinoma, Squamous Cell
Characterization of the beta 2-adrenoceptor-dependent adenylate cyclase of A431 epidermoid carcinoma cells.
Carcinoma, Squamous Cell
Further evidence for a novel receptor for amino-terminal parathyroid hormone-related protein on keratinocytes and squamous carcinoma cell lines.
Carcinoma, Squamous Cell
Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.
Carcinoma, Squamous Cell
Studies on cyclic AMP metabolism in human epidermoid carcinoma (HEp-2) cells.
Carcinoma, Squamous Cell
Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptor.
Carcinoma, Squamous Cell
[The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)]
Carcinosarcoma
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Cardiomegaly
A different desensitization pattern of cardiac beta-adrenoceptor subtypes by prolonged in vivo infusion of isoprenaline.
Cardiomegaly
Adenylate cyclase activity during development and reversal of cardiac hypertrophy.
Cardiomegaly
Alterations in the inotropic responses to forskolin and Ca2+ and reduced gene expressions of Ca2+-signaling proteins induced by chronic volume overload in rabbits.
Cardiomegaly
Beta-adrenergic signal transduction in the failing and hypertrophied myocardium.
Cardiomegaly
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Cardiomegaly
Cardiac beta-adrenergic signaling pathway alteration in isoproterenol-induced cardiac hypertrophy in male Sprague-Dawley rats.
Cardiomegaly
Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects.
Cardiomegaly
Cardiomegaly induced by pressure overload in newborn rats is accompanied by altered expression of the long isoform of G(s)alpha protein and deranged signaling of adenylyl cyclase.
Cardiomegaly
Catecholamine-induced cardiac hypertrophy uncouples beta-adrenoceptors from slow calcium channels.
Cardiomegaly
Correlation of myosin heavy chain expression in the rat with cAMP in different models of hypertension-induced cardiac hypertrophy.
Cardiomegaly
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Cardiomegaly
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Cardiomegaly
Enhancement of the cardiac beta-adrenergic system at an early diabetic state in spontaneously diabetic Chinese hamsters.
Cardiomegaly
Isoprenaline-induced increase in mRNA levels of inhibitory G-protein alpha-subunits in rat heart.
Cardiomegaly
Isoproterenol-induced cardiac hypertrophy: modifications in characteristics of beta-adrenergic receptor, adenylate cyclase, and ventricular contraction.
Cardiomegaly
Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts.
Cardiomegaly
Regression of thyroid hormone induced cardiac hypertrophy: effect on cardiac beta receptors and adenyl cyclase activity.
Cardiomegaly
Ribonucleic acid (RNA) polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
Cardiomegaly
Role of G-proteins in altered beta-adrenergic responsiveness in the failing and hypertrophied myocardium.
Cardiomegaly
Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload.
Cardiomegaly
Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart.
Cardiomyopathies
Abnormalities in heart membranes and myofibrils during bacterial infective cardiomyopathy in the rabbit.
Cardiomyopathies
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.
Cardiomyopathies
Activity of receptors coupled to guanine nucleotide binding regulatory protein in doxorubicin induced cardiomyopathy.
Cardiomyopathies
Adenylate cyclase activity coupled to the stimulatory guanine nucleotide binding protein in patients having electrophysiologic studies and either structurally normal hearts or idiopathic myocardial disease.
Cardiomyopathies
Adenylyl cyclase 6 deletion increases mortality during sustained ?-adrenergic receptor stimulation.
Cardiomyopathies
Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy.
Cardiomyopathies
Adenylyl cyclase type VI gene transfer reduces phospholamban expression in cardiac myocytes via activating transcription factor 3.
Cardiomyopathies
Beta-adrenoceptor antibodies and genetics in dilated cardiomyopathy--an overview and review.
Cardiomyopathies
Bitransgenesis with beta(2)-Adrenergic Receptors or Adenylyl Cyclase Fails to Improve beta(1)-Adrenergic Receptor Cardiomyopathy.
Cardiomyopathies
Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy.
Cardiomyopathies
Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy.
Cardiomyopathies
Catecholamine-responsive adenylate cyclase activity in human endomyocardial biopsies. Individual sensitivity to isoproterenol stimulation and propranolol inhibition.
Cardiomyopathies
Decreased bioactivity of the guanine nucleotide-binding protein that stimulates adenylate cyclase in hearts from cardiomyopathic Syrian hamsters.
Cardiomyopathies
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
Cardiomyopathies
Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of G{alpha}q protein-induced cardiomyopathy.
Cardiomyopathies
Disruption of type 5 adenylyl cyclase prevents ?-adrenergic receptor cardiomyopathy: a novel approach to ?-adrenergic receptor blockade.
Cardiomyopathies
Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs.
Cardiomyopathies
Molecular mechanism of hypertrophied failing heart--abnormalities of the diastolic properties and contractility.
Cardiomyopathies
Myocardial beta-adrenergic adenylate cyclase complex in a canine model of chagasic cardiomyopathy.
Cardiomyopathies
Ribonucleic acid (RNA) polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
Cardiomyopathies
RNA polymerase and adenyl cyclase in cardiac hypertrophy and cardiomyopathy.
Cardiomyopathies
Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats.
Cardiomyopathies
The activity of adenylate cyclase and phosphodiesterase in the isoproterenol-damaged cardiac muscle of spontaneously hypertensive rats.
Cardiomyopathies
Verapamil ameliorates clinical, pathologic and biochemical manifestations of experimental chagasic cardiomyopathy in mice.
Cardiomyopathy, Dilated
Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy.
Cardiomyopathy, Dilated
Assessment of immune modulation of beta-adrenergic pathways in human dilated cardiomyopathy: influence of methodologic factors.
Cardiomyopathy, Dilated
Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.
Cardiomyopathy, Dilated
Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy.
Cardiomyopathy, Dilated
Effects of chronic application of propranolol on beta-adrenergic signal transduction in heart ventricles from myopathic BIO TO2 and control hamsters.
Cardiomyopathy, Dilated
Effects of forskolin on left ventricular function in dilated cardiomyopathy.
Cardiomyopathy, Dilated
Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure.
Cardiomyopathy, Dilated
Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate.
Cardiomyopathy, Dilated
Influence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathy.
Cardiomyopathy, Dilated
Influence of forskolin on the force-frequency behavior in nonfailing and end-stage failing human myocardium.
Cardiomyopathy, Dilated
Inhibition of endogenous nitric oxide synthase augments contractile response to adenylyl cyclase stimulation without altering mechanical efficiency in patients with idiopathic dilated cardiomyopathy.
Cardiomyopathy, Dilated
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Cardiomyopathy, Dilated
Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy.
Cardiomyopathy, Dilated
Vidarabine, an Anti-Herpes Virus Agent, Protects Against the Development of Heart Failure With Relatively Mild Side-Effects on Cardiac Function in a Canine Model of Pacing-Induced Dilated Cardiomyopathy.
Cardiomyopathy, Hypertrophic
Effects of chronic infusion of norepinephrine on cardiac structure, function, and biochemistry: physiologic versus pathologic hypertrophy.
Cardiomyopathy, Hypertrophic
Hypertrophic cardiomyopathy characterised by beta-adrenoceptor density, relative amount of beta-adrenoceptor subtypes and adenylate cyclase activity.
Cardiovascular Abnormalities
Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment.
Cardiovascular Diseases
Modulation of Gi Proteins in Hypertension: Role of Angiotensin II and Oxidative Stress.
Cardiovascular Diseases
Regulation of Gi? protein expression by vasoactive peptides in hypertension: molecular mechanisms.
Catalepsy
Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism.
Catalepsy
The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells.
Cerebral Palsy
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Chagas Disease
Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease.
Chagas Disease
Stimulation of Trypanosoma cruzi adenylyl cyclase by an alpha D-globin fragment from Triatoma hindgut: effect on differentiation of epimastigote to trypomastigote forms.
Chagas Disease
Verapamil ameliorates clinical, pathologic and biochemical manifestations of experimental chagasic cardiomyopathy in mice.
Cholangiocarcinoma
Alpha(1)-and beta(2)-adrenoceptors in the human liver with mass-forming intrahepatic cholangiocarcinoma: density and coupling to adenylate cyclase and phospholipase C.
Cholangitis
Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis.
Cholangitis, Sclerosing
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
Cholera
1,2-Diacylglycerols overcome cyclic AMP-mediated inhibition of phosphatidylcholine synthesis in GH3 pituitary cells.
Cholera
12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Cholera
2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.
Cholera
3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.
Cholera
6,7-Dihydroxy-2-dimethylaminotetralin (TL-99) stimulates postjunctional D-1 and D-2 dopamine receptors.
Cholera
7-oxa-13-prostynoic acid and polyphloretin phosphate as non-specific antagonists of the stimulatory effects of different agents on adenylate cyclase from various tissues.
Cholera
A conjugate of the A1 peptide of cholera toxin and the lectin of Wisteria floribunda that activates the adenylate cyclase of intact cells.
Cholera
A Gs protein couples P2-purinergic stimulation to cardiac Ca channels without cyclic AMP production.
Cholera
A human pituitary adenoma secreting thyrotropin and prolactin: immunohistochemical, biochemical, and cell culture studies.
Cholera
A mu-opiate receptor in 7315c tumor tissue mediates inhibition of immunoreactive prolactin release and adenylate cyclase activity.
Cholera
A new principle for resistance to cholera: desensitization to cyclic AMP-mediated diarrhea induced by cholera toxin in the mouse intestine.
Cholera
A novel synergistic stimulation of Swiss 3T3 cells by extracellular ATP and mitogens with opposite effects on cAMP levels.
Cholera
A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells.
Cholera
A second guanyl nucleotide-binding site associated with adenylate cyclase. Distinct nucleotides activate adenylate cyclase and permit ADP-ribosylation by cholera toxin.
Cholera
A viral K-RAS protein increases the stimulability of adenylate cyclase by cholera toxin in NRK cells.
Cholera
AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera.
Cholera
Acetylcholine and cholecystokinin receptors functionally couple by different G-proteins to phospholipase C in pancreatic acinar cells.
Cholera
Acetylcholine inhibits positive inotropic effect of cholera toxin in ventricular muscle.
Cholera
Acetylcholine-induced biphasic effect on the maximum upstroke velocity of action potential in mouse right atria: interaction with beta-adrenergic signaling cascade.
Cholera
ACh-induced rebound stimulation of L-type Ca(2+) current in guinea-pig ventricular myocytes, mediated by Gbetagamma-dependent activation of adenylyl cyclase.
Cholera
Activation of adenylate cyclase by alcohols requires the nucleotide-binding protein.
Cholera
Activation of cAMP-dependent pathways in human airway smooth muscle cells inhibits TNF-alpha-induced ICAM-1 and VCAM-1 expression and T lymphocyte adhesion.
Cholera
Activation of Escherichia coli heat-labile enterotoxins by native and recombinant adenosine diphosphate-ribosylation factors, 20-kD guanine nucleotide-binding proteins.
Cholera
Activation of FSH-responsive adenylate cyclase by staurosporine: role for protein phosphorylation in gonadotropin receptor desensitization.
Cholera
Activation of hepatic adenylate cyclase by guanyl nucleotides. Modeling of the transient kinetics suggests an "excited" state of GTPase is a control component of the system.
Cholera
Activation of human synovial cells by cholera enterotoxin: correlation of morphological responses with adenylate cyclase activities, and the reversing effects of hyaluronidase.
Cholera
Activation of immobilized, biotinylated choleragen AI protein by a 19-kilodalton guanine nucleotide-binding protein.
Cholera
Activation of intestinal mucosal adenylate cyclase by Shigella dysenteriae I enterotoxin.
Cholera
Activation of pigeon erythrocyte adenylate cyclase by cholera toxin. Partial purification of an essential macromolecular factor from horse erythrocyte cytosol.
Cholera
Activation of rat liver adenylate cyclase by cholera toxin requires toxin internalization and processing in endosomes.
Cholera
Activation of STAT3 by G alpha(s) distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase.
Cholera
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.
Cholera
Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways.
Cholera
Activation of the nigrostriatal dopaminergic pathway by injection of cholera enterotoxin into the substantia nigra.
Cholera
Activators of adenylate cyclase and cyclic AMP prolong calcium-dependent action potentials of mouse sensory neurons in culture by reducing a voltage-dependent potassium conductance.
Cholera
Activity of covalently cross-linked cholera toxin with the adenylate cyclase of intact and lysed pigeon erythrocytes.
Cholera
Acute variations in extracellular pH modulate transduction pathways of PTH in rat proximal tubule.
Cholera
Adaptive changes in the number of Gs- and Gi-proteins underlie adenylyl cyclase sensitization in morphine-treated rat striatal neurons.
Cholera
Adenosine 3',5'-monophosphate suppresses metastatic spread in nude mice of steroidogenic rat granulosa cells transformed by simian virus-40 and Ha-ras oncogene.
Cholera
Adenosine 3':5'-cyclic monophosphate inhibits in vitro angiogenesis induced by endothelial cell growth factor.
Cholera
Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723.
Cholera
Adenosine diphosphate-ribosylation of adenylate cyclase catalyzed by heat-labile enterotoxin of Escherichia coli: comparison with cholera toxin.
Cholera
Adenosine reverses the stimulatory effect of angiotensin II on the renal Na+-ATPase activity through the A2 receptor.
Cholera
Adenylate cyclase activation by cholera toxin in pig epidermis: an obligatory role of the GTP-regulatory protein.
Cholera
Adenylate cyclase activators and inhibitors, cyclic nucleotide analogs, and phosphatidylinositol: effects on interrenal function of coho salmon (Oncorhynchus kisutch) in vitro.
Cholera
Adenylate cyclase activity and cyclic adenosine monophosphate levels in colon cancer lines and dermal fibroblasts and the effects of cholera toxin and epidermal growth factor.
Cholera
Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate.
Cholera
Adenylate cyclase from rabbit small intestine: activation by cholera toxin and interaction with calcium.
Cholera
Adenylate cyclase in human cytotrophoblasts: characterization and its role in modulating human chorionic gonadotropin secretion.
Cholera
Adenylate cyclase in intestinal crypt and villus cells: stimulation by cholera enterotoxin and prostaglandin E1.
Cholera
Adenylate cyclase in Xenopus laevis oocytes: characterization of the progesterone-sensitive, membrane-bound form.
Cholera
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
Cholera
Adenylate cyclase system in fetal rat keratinizing epidermal cells (FRSK cells) and SV40-transformed human keratinocytes.
Cholera
Adenylyl cyclase-cAMP system inhibits thyroid hormone-stimulated osteocalcin synthesis in osteoblasts.
Cholera
Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes.
Cholera
Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen.
Cholera
ADP-ribosylation by cholera toxin of membranes derived from brain modifies the interaction of adenylate cyclase with guanine nucleotides and NaF.
Cholera
ADP-ribosylation factor is functionally and physically associated with the Golgi complex.
Cholera
ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin.
Cholera
ADP-ribosylation of membrane proteins and activation of adenylate cyclase by cholera toxin in fat cell ghosts from euthyroid and hypothyroid rats.
Cholera
ADP-ribosylation of membrane proteins catalyzed by cholera toxin: basis of the activation of adenylate cyclase.
Cholera
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
Cholera
Adrenal cortex adenylate cyclase. In vitro modification of the enzyme by cholera toxin.
Cholera
Age-associated decrease in vasopressin-induced renal water transport: a role for adenylate cyclase and G protein malfunction.
Cholera
Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells.
Cholera
Agents affecting adenylate cyclase activity modulate the stimulatory action of 1,25-dihydroxyvitamin D3 on the production of osteocalcin by human bone cells.
Cholera
Agonist-induced subsensitivity of adenylate cyclase coupled with a dopamine receptor in slices from rat corpus striatum.
Cholera
Alkaline phosphatases and adenylate cyclase in the normal and desensitized rat small intestine after acute cholera toxin challenge: a histochemical study.
Cholera
Alpha 2-adrenergic regulation of arylalkylamine N-acetyltransferase in organ-cultured chick pineal gland: characterization with agonists and modulation of experimentally stimulated enzyme activity.
Cholera
Alpha 2-adrenoceptor-GTP binding regulatory protein-adenylate cyclase system in cerebral cortical membranes of adult and senescent rats.
Cholera
Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.
Cholera
Alteration by v-Ki-ras in NaF, cholera toxin and forskolin-induced adenylate cyclase activation in NIH/3T3 fibroblast cells.
Cholera
Alterations in cardiac membrane beta-adrenoceptors and adenylyl cyclase due to hypochlorous acid.
Cholera
Alterations in g-protein-linked signal transduction in vascular smooth muscle in diabetes.
Cholera
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Cholera
Altered guanine nucleotide hydrolysis as basis for increased adenylate cyclase activity after cholera toxin treatment.
Cholera
Amiodarone compared with iodine exhibits a potent and persistent inhibitory effect on TSH-stimulated cAMP production in vitro: a possible mechanism to explain amiodarone-induced hypothyroidism.
Cholera
An increase in adenylate cyclase activity precedes DNA synthesis in cultured vascular smooth muscle cells.
Cholera
An investigation of the role of possible neural mechanisms in cholera toxin-induced secretion in rabbit ileal mucosa in vitro.
Cholera
An Mr = 52,000 peptide can mediate effects on cholera toxin on adenylate cyclase in intact cells.
Cholera
Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells).
Cholera
Angiotensin II enhancement of hormone-stimulated cAMP formation in cultured vascular smooth muscle cells.
Cholera
Antagonistic effects of thyrotropin and epidermal growth factor on thyroglobulin mRNA level in cultured thyroid cells.
Cholera
Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes.
Cholera
Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity.
Cholera
Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins.
Cholera
beta-Adrenergic receptor activation increases acetylcholine receptor number in cultured skeletal muscle myotubes.
Cholera
beta-Adrenergic receptor agonists increase phospholipid methylation, membrane fluidity, and beta-adrenergic receptor-adenylate cyclase coupling.
Cholera
Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals.
Cholera
Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced.
Cholera
Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon.
Cholera
Biochemistry of Vibrio cholerae virulence: purification of cholera enterotoxin by preparative disc electrophoresis.
Cholera
Biphasic action of forskolin on growth hormone and prolactin secretion by rat anterior pituitary cells in vitro.
Cholera
Biphasic alterations in cardiac beta-adrenoceptor signal transduction mechanism due to oxyradicals.
Cholera
Biphasic effect of sodium fluoride and guanyl nucleotides on binding to prostaglandin E2 receptors in rat epididymal adipocyte membranes.
Cholera
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Cholera
Both cholera toxin-induced adenylate cyclase activation and cholera toxin biological activity are inhibited by antibodies against related synthetic peptides.
Cholera
Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins.
Cholera
Bradykinin stimulates cAMP synthesis via mitogen-activated protein kinase-dependent regulation of cytosolic phospholipase A2 and prostaglandin E2 release in airway smooth muscle.
Cholera
Brefeldin A blocks the response of cultured cells to cholera toxin. Implications for intracellular trafficking in toxin action.
Cholera
Calcitonin gene-related peptide and muscle activity regulate acetylcholine receptor alpha-subunit mRNA levels by distinct intracellular pathways.
Cholera
Calcitonin gene-related peptide receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+ signaling pathways.
Cholera
Calcitonin gene-related peptide stimulates intracellular cAMP via a protein kinase C-controlled mechanism in human ocular ciliary epithelial cells.
Cholera
Calcitonin gene-related peptide, a peptide present in spinal cord motoneurons, increases the number of acetylcholine receptors in primary cultures of chick embryo myotubes.
Cholera
Calcium and cAMP are second messengers in the adipokinetic hormone-induced lipolysis of triacylglycerols in Manduca sexta fat body.
Cholera
cAMP elevating agents suppress secretory phospholipase A(2)-induced matrix metalloproteinase-2 activation.
Cholera
cAMP in ovine oocytes: localization of synthesis and its action on protein synthesis, phosphorylation, and meiosis.
Cholera
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Cholera
Catecholamine-induced heterologous desensitization of rabbit luteal adenylyl cyclase: loss of luteinizing hormone responsiveness is associated with impaired G-protein function.
Cholera
Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP.
Cholera
Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay.
Cholera
Cell junction and cycle AMP: III. Promotion of junctional membrane permeability and junctional membrane particles in a junction-deficient cell type.
Cholera
Cell type and receptor identity regulate cholera toxin subunit B (CTB) internalization.
Cholera
Characterization of the homologous and heterologous desensitization of rat Leydig-tumour-cell adenylate cyclase.
Cholera
Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase.
Cholera
Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells.
Cholera
Cholera and pertussis toxins modify regulation of glucose transport activity in rat adipose cells: evidence for mediation of a cAMP-independent process by G-proteins.
Cholera
Cholera toxin action on rabbit corpus luteum membranes: effects on adenylyl cyclase activity and adenosine diphospho-ribosylation of the stimulatory guanine nucleotide-binding regulatory component.
Cholera
Cholera toxin activation of adenylate cyclase. Roles of nucleoside triphosphates and a macromolecular factor in the ADP ribosylation of the GTP-dependent regulatory component.
Cholera
Cholera toxin ADP-ribosylates the islet-activating protein substrate in adipocyte membranes and alters its function.
Cholera
Cholera toxin and adenylate cyclase: properties of the activated enzyme in liver plasma membranes.
Cholera
Cholera toxin and membrane gangliosides: binding and adenylate cyclase activation in normal and transformed cells.
Cholera
Cholera toxin antagonizes morphine-induced catalepsy through a cyclic AMP-independent mechanism.
Cholera
Cholera toxin augmented epinephrine response to adenylate cyclase not decreased after prolonged in vitro incubation of isolated fat cells.
Cholera
Cholera toxin blocks glucagon-mediated inhibition of the liver plasma membrane (Ca2+-Mg2+)-ATPase.
Cholera
Cholera toxin can recouple hormone receptors that are uncoupled from adenylate cyclase.
Cholera
Cholera toxin covalently linked with horseradish peroxidase does not activate the adenylate cyclase of neuroblastoma cells.
Cholera
Cholera toxin differentially decreases membrane levels of alpha and beta subunits of G proteins in NG108-15 cells.
Cholera
Cholera toxin does not impair hormonal inhibition of adenylate cyclase and concomitant stimulation of a GTPase in adipocyte membranes.
Cholera
Cholera toxin effects on fluid secretion, adenylate cyclase, and cyclic AMP in porcine small intestine.
Cholera
Cholera toxin enhances adenylate cyclase-dependent transport in toad urinary bladder.
Cholera
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Cholera
Cholera toxin induces changes in the ion permeability of intestinal brush border membranes.
Cholera
Cholera toxin inhibits HIV-1 replication in human colorectal epithelial HT-29 cells through adenylate cyclase activation.
Cholera
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Cholera
Cholera toxin requires oxidized nicotinamide-adenine dinucleotide to activate adenylate cyclase in purified rat liver plasma membranes.
Cholera
Cholera toxin resistance associated with deficient adenylate-cyclase activity in a subclone of the rat promyelocytic leukemia (BNML).
Cholera
Cholera toxin stimulates adenosine 3',5'-monophosphate synthesis and epithelial wound closure in the rabbit cornea.
Cholera
Cholera toxin treatment increases in vivo growth and development of the mouse mammary gland.
Cholera
Cholera toxin- and forskolin-induced cyclic AMP accumulations of pig skin (epidermis). Modulation by chemicals which reveal the beta-adrenergic augmentation effect.
Cholera
Cholera toxin-catalysed ADP-ribosylation of erythrocyte proteins: general properties.
Cholera
Cholera toxin-mediated inhibition of signalling in Jurkat cells is followed by, but not due to a loss of T cell receptor complex.
Cholera
Cholera toxin-stimulated bone resorption in cultured mouse calvarial bones not inhibited by calcitonin: a possible interaction at the stimulatory G protein.
Cholera
Cholinergic inhibition of catecholamine-stimulable cyclic AMP accumulation in murine atria.
Cholera
Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins.
Cholera
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Cholera
Chronic nonocclusive coronary artery constriction in rats. Beta-adrenoceptor signal transduction and ventricular failure.
Cholera
Cold-induced beta-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription.
Cholera
Comments on 'The activation of adenylate cyclase from small intestinal epithelium by cholera toxin'.
Cholera
Comparison of the interaction of mono- and oligovalent ligands with cholera toxin. Demonstration of aggregate formation at low ligand concentrations.
Cholera
Complete response to vasopressin requires epithelial organization in A6 cells in culture.
Cholera
Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP.
Cholera
Constitutive steroidogenesis in the R2C Leydig tumor cell line is maintained by the adenosine 3',5'-cyclic monophosphate-independent production of a cycloheximide-sensitive factor that enhances mitochondrial pregnenolone biosynthesis.
Cholera
Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs.
Cholera
Contact-dependent cell interactions determine hormone responsiveness and desensitization in rat granulosa cells.
Cholera
Control of plasminogen activator activity in the thecal layer of the largest preovulatory follicle in the hen ovary.
Cholera
Coordinate regulation of adenylate cyclase, protein kinase, and specific enzyme synthesis by cholera toxin in hormonally unresponsive hepatoma cells.
Cholera
Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.
Cholera
Cyclic adenosine-3',5'-monophosphate stimulates the acute release of placental lactogen from human trophoblast cells.
Cholera
Cyclic AMP and calcium as potential mediators of stimulation of cultured Schwann cell proliferation by axolemma-enriched and myelin-enriched membrane fractions.
Cholera
Cyclic AMP and its receptor protein negatively regulate the coordinate expression of cholera toxin and toxin-coregulated pilus in Vibrio cholerae.
Cholera
Cyclic AMP concentrations modulate both calcium flux and hydrolysis of phosphatidylinositol phosphates in mouse T lymphocytes.
Cholera
Cyclic AMP increasing agents rapidly stimulate vimentin phosphorylation in quiescent cultures of Swiss 3T3 cells.
Cholera
Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells.
Cholera
Cyclic AMP regulation of Gs protein. Thyrotropin and forskolin increase the quantity of stimulatory guanine nucleotide-binding proteins in cultured thyroid follicles.
Cholera
Cyclic AMP-dependent modulation of vesicular monoamine transport in pheochromocytoma cells.
Cholera
Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils.
Cholera
Cytidylate cyclase activity is stimulated via activation of a guanine nucleotide-binding protein.
Cholera
Cytochemistry of adenylate cyclase: action of cholera toxin on the adenylate cyclase of pigeon erythrocytes.
Cholera
D-2 dopamine receptor-mediated inhibition of adenylate cyclase activity in the intermediate lobe of the rat pituitary gland requires guanosine 5'-triphosphate.
Cholera
Decrease in cAMP levels promoted by CD48-CD2 interaction correlates with inhibition of apoptosis in B cells.
Cholera
Decrease in coupling of Gs in v-src-transformed NIH-3T3 fibroblasts: possible involvement of tyrosine phosphorylation of Gs by pp60v-src.
Cholera
Decreased adenylate cyclase responsiveness of transformed cells correlates with the presence of a viral transforming protein.
Cholera
Deficient activity of receptor-cyclase coupling protein is transformed lymphoblasts of patients with pseudohypoparathyroidism, type I.
Cholera
Dehydroepiandrosterone sulfate (DHEA-S) and 3', 5'-cyclic adenosine monophosphate (cAMP) production in a cultured human adrenocortical carcinoma cell line (SW-13).
Cholera
Depletion of protein kinase C-alpha by antisense oligonucleotides alters beta-adrenergic function and reverses the phorbol ester-induced reduction of isoproterenol-induced adenosine 3'-5'-cyclic monophosphate accumulation in murine Swiss 3T3 fibroblasts.
Cholera
Desensitization of beta-adrenergic receptors in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog.
Cholera
Desensitization of the cAMP system in mouse Leydig cells by hCG, cholera toxin, dibutyryl cAMP and cAMP: localization of the 'lesion' to the guanine nucleotide regulatory protein-adenylate cyclase complex.
Cholera
Desensitization of the thyroid cyclic AMP response to thyroid stimulating immunoglobulin: comparison with TSH.
Cholera
Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice.
Cholera
Determination of the turn-off reaction for the epinephrine-inhibited human platelet adenylate cyclase.
Cholera
Development of activatable adenylate cyclase in the preimplantation mouse embryo and a role for cyclic AMP in blastocoel formation.
Cholera
Development of intestinal host defense: an increased sensitivity in the adenylate cyclase response to cholera toxin in suckling rats.
Cholera
Development of physiological responsiveness to glucagon during embryogenesis of avian heart.
Cholera
Developmental alterations in guanine nucleotide regulation of the beta-adrenergic receptor-adenylate cyclase system of skeletal muscle.
Cholera
Developmental differences in the expression of the cholera toxin sensitive subunit (Gs alpha) of adenylate cyclase in the rat small intestine.
Cholera
Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells.
Cholera
Dibutyryl cyclic adenosine 3',5'-monophosphate: its role in regulation of cat brain extracellular fluid.
Cholera
Dichlorodiphenyltrichloroethane impairs follicle-stimulating hormone receptor-mediated signaling in rat Sertoli cells.
Cholera
Different inhibitory effect of adrenaline on platelet adenylate cyclase in the presence of GTP plus cholera toxin and of stable GTP analogues.
Cholera
Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro.
Cholera
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
Cholera
Differential effects of cholera toxin on guanine nucleotide regulation of beta-adrenergic agonist high affinity binding and adenylate cyclase activation in frog erythrocyte membranes.
Cholera
Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue.
Cholera
Differential effects of tumor promoters on cAMP production: inhibition of receptor-mediated and potentiation of cholera toxin-mediated stimulation.
Cholera
Differential regulation of hCG and progesterone secretion by cholera toxin and phorbol ester in human cytotrophoblasts.
Cholera
Differential regulation of P2Y(11) receptor-mediated signalling to phospholipase C and adenylyl cyclase by protein kinase C in HL-60 promyelocytes.
Cholera
Differential regulation of receptor-stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3-E1 osteoblasts.
Cholera
Differential roles of high and low affinity guanosine 5'-triphosphate binding sites in the regulation of follicle-stimulating hormone binding to receptor and signal transduction in bovine calf testis membranes.
Cholera
Differential susceptibility to GTP formed from added GDP via membrane-associated nucleoside diphosphate kinase of GTP-sensitive adenylate cyclases achieved by hormone and cholera toxin.
Cholera
Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters.
Cholera
Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.
Cholera
Discordance in the effects of interleukin-1 on rat granulosa cell differentiation induced by follicle-stimulating hormone or activators of adenylate cyclase.
Cholera
Discrepancy between effects of cholera toxin on net fluid movement and cAMP levels in rat jejunum, ileum, and colon.
Cholera
Dissociation by cooling of hormone and cholera toxin activation of adenylate cyclase in intact cells.
Cholera
Distinct effects of the C-terminal octapeptide of cholecystokinin and of a cholera toxin pretreatment of the kinetics of rat pancreatic adenylate cyclase activity.
Cholera
Does enteropathogenic Escherichia coli produce heat-labile enterotoxin, heat-stable enterotoxins a or b, or cholera toxin A subunits?
Cholera
Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium.
Cholera
Down-regulation of protein kinase C by parathyroid hormone and mezerein differentially modulates cAMP production and phosphate transport in opossum kidney cells.
Cholera
Dual bradykinin B2 receptor signalling in A431 human epidermoid carcinoma cells: activation of protein kinase C is counteracted by a GS-mediated stimulation of the cyclic AMP pathway.
Cholera
Dual regulation of ?2-adrenoceptor messenger RNA expression in human lung fibroblasts by ?2-cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression.
Cholera
Early effect of progesterone on levels of cyclic adenosine 3':5'-monophosphate in Xenopus oocytes.
Cholera
Effect of ageing on adenylate cyclase activity and G-proteins in rat submandibular salivary glands.
Cholera
Effect of calcitonin gene-related peptide on skeletal muscle via specific binding site and G protein.
Cholera
Effect of cholera enterotoxin on pacemaker rate and cyclic adenosine 3':5'-monophosphate in isolated rabbit sinoatrial node.
Cholera
Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus.
Cholera
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Cholera
Effect of cholera toxin on the activation of adenylate cyclase by calmodulin in bovine striatum.
Cholera
Effect of glucocorticoid on prostaglandin E1 mediated cyclic AMP formation by vascular smooth muscle cells.
Cholera
Effect of prostaglandin E2 and other intracellular cyclic AMP elevating agents on the mitogen induced mouse splenocyte proliferation in a serum free culture condition.
Cholera
Effect of thyrotropin-induced desensitization of bovine thyroid adenylate cyclase on the nucleotide regulatory protein.
Cholera
Effects of adenosine 3',5'-cyclic monophosphate, forskolin, and cholera toxin on hormone production in human term placental cells.
Cholera
Effects of alpha 2-adrenergic agonist preincubation on subsequent forskolin-stimulated adenylate cyclase activity and [3H]forskolin binding in membranes from HT29 cells.
Cholera
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase.
Cholera
Effects of cholera enterotoxin, glucagon, and dibutyryl cyclic AMP on rat liver alkaline phosphatase, bile flow, and bile composition.
Cholera
Effects of cholera toxin and 5'-guanylylimidodiphosphate on human spermatozoal adenylate cyclase activity.
Cholera
Effects of cholera toxin and guanosine 5'-[betagamma-imido]triphosphate on beta-adrenergic-receptor affinity.
Cholera
Effects of cholera toxin on adenylate cyclase. Studies with guanylylimidodiphosphate.
Cholera
Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops.
Cholera
Effects of cholera toxin on cyclic adenosine 3',5'-monophosphate concentration and secretory processes in the exocrine pancreas.
Cholera
Effects of cholera toxin on cyclic AMP accumulation and bone resorption in cultured mouse calvaria.
Cholera
Effects of cyclic adenosine 3':5'-monophosphate upon glycoprotein and carcinoembryonic antigen synthesis and release by human colon cancer cells.
Cholera
Effects of intravitreal cholera toxin on adenosine 3',5'-monophosphate, intraocular pressure, and outflow facility in rabbits.
Cholera
Effects of long-term alcohol intake on ADP ribosylation in rat liver plasma membranes.
Cholera
Effects of modulators of adenylyl cyclase on interleukin-2 production, cytosolic Ca2+ elevation, and K+ channel activity in Jurkat T cells.
Cholera
Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy.
Cholera
Effects of phospholipid and GTP on recombinant ADP-ribosylation factors (ARFs). Molecular basis for differences in requirements for activity of mammalian ARFs.
Cholera
Effects of prostaglandin E2, forskolin and cholera toxin on cAMP production and in vitro LH-RH release from the rat hypothalamus.
Cholera
Effects of proteolytic enzymes and protease inhibitors on bovine thyroid adenylate cyclase activity.
Cholera
Effects of temperature on ADP-ribosylation factor stimulation of cholera toxin activity.
Cholera
Effects of thyrotropin and cholera toxin on the thyroidal adenylate cyclase-adenosine 3',5'-monophosphate system.
Cholera
Effects of Vibrio cholerae enterotoxin peptide on glomerular filtration rate and renal proximal tubular sodium transport.
Cholera
Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase.
Cholera
Enhanced degradation of stimulatory G-protein (Gs alpha) by cholera toxin is mediated by ADP-ribosylation of Gs alpha protein but not by increased cyclic AMP levels.
Cholera
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Cholera
Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition.
Cholera
Enzymatic and immunological detection of G protein alpha-subunits in the pathogenic fungus Candida albicans.
Cholera
Epidermal adenylate cyclase system is regulated by diacylglycerol-protein kinase C signal, but not by calcium signal.
Cholera
Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein.
Cholera
Epidermal growth factor but not insulin-like growth factor-I potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Cholera
Epidermal growth factor stimulates formation of inositol phosphates in BALB/c/3T3 cells pretreated with cholera toxin and isobutylmethylxanthine.
Cholera
Essential role of GTP in the expression of adenylate cyclase activity after cholera toxin treatment.
Cholera
Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis.
Cholera
Estrogen and progesterone augment growth responsiveness of mammary tissue to cholera toxin.
Cholera
Estrogen and uterine sensitization for the decidual cell reaction in the rat: role of prostaglandin E2 and adenosine 3':5'-cyclic monophosphate.
Cholera
Ethanol-induced desensitization of adenylate cyclase: role of the adenosine receptor and GTP-binding proteins.
Cholera
Evidence for a rabbit luteal ADP-ribosyltransferase activity which appears to be capable of activating adenylyl cyclase.
Cholera
Evidence for role of glycoprotein carbohydrates in membrane transport: specific inhibition by tunicamycin.
Cholera
Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.
Cholera
Evidence that human platelet alpha-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by cholera toxin.
Cholera
Evidence that the cAMP pathway controls emergence of both primary and appressorial germ tubes of barley powdery mildew.
Cholera
Evidence that the D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland is associated with an inhibitory guanyl nucleotide component.
Cholera
Expression of cDNAs for G proteins in Escherichia coli. Two forms of Gs alpha stimulate adenylate cyclase.
Cholera
Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP.
Cholera
Extra-long G?s variant XL?s protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling.
Cholera
Fasting increases fat cell adenylate cyclase sensitivity to stimulatory agonists through enhanced ability of the stimulatory regulatory component Ns to dissociate.
Cholera
Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts.
Cholera
Filipin-dependent inhibition of cholera toxin: evidence for toxin internalization and activation through caveolae-like domains.
Cholera
Fine structural studies of ciliary processes after treatment with cholera toxin or its B subunit.
Cholera
Follicle-stimulating hormone (FSH) increases FSH receptor messenger ribonucleic acid while decreasing FSH binding in cultured porcine granulosa cells.
Cholera
Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase.
Cholera
Forskolin but not cholera toxin bypasses flufenamate-induced inhibition of cAMP production in anterior pituitaries.
Cholera
Forskolin potentiation of cholera toxin-stimulated cyclic AMP accumulation in intact C6-2B cells. Evidence for enhanced Gs-C coupling.
Cholera
Forskolin-resistant Y1 mutants harbor defects associated with the guanyl nucleotide-binding regulatory protein, Gs.
Cholera
From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones.
Cholera
Functional alteration of guanine nucleotide binding proteins (Gs and Gi) in psoriatic epidermis.
Cholera
Functional homology between signal-coupling proteins. Cholera toxin inactivates the GTPase activity of transducin.
Cholera
Functional modification by cholera-toxin-catalyzed ADP-ribosylation of a guanine-nucleotide-binding regulatory protein serving as the substrate of pertussis toxin.
Cholera
Functional properties of polyclonal antibodies raised against the N-terminus region (residues 9-30) of the follicle-stimulating hormone (FSH) receptor: significance of this receptor region in FSH recognition and signal transduction.
Cholera
Further characterization of the iodide inhibitory effect on the cyclic AMP system in dog thyroid slices.
Cholera
Further studies on the mode of action of calcitonin on isolated rat osteoclasts: pharmacological evidence for a second site mediating intracellular Ca2+ mobilization and cell retraction.
Cholera
G protein and cAMP-dependent protein kinase mediate amyloid beta-peptide inhibition of neuronal glucose uptake.
Cholera
G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
Cholera
G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions.
Cholera
Ganglioside GM1 binding toxins and human neuropathy-associated IgM antibodies differentially promote neuritogenesis in a PC12 assay.
Cholera
Gastrin in the perinatal rat pancreas and gastric antrum: immunofluorescence localization of pancreatic gastrin cells and gastrin secretion in monolayer cell cultures.
Cholera
GDP does not support activation of adenylate cyclase nor ADP-ribosylation of a guanine nucleotide binding protein by cholera toxin.
Cholera
Generation of cell surface neoganglioproteins. GM1-neoganglioproteins are non-functional receptors for cholera toxin.
Cholera
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase.
Cholera
Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor.
Cholera
Glucose modifies the cross-talk between insulin and the beta-adrenergic signalling system in vascular smooth muscle cells.
Cholera
GM1 ganglioside modulates prostaglandin E1 stimulated adenylyl cyclase in neuro-2A cells.
Cholera
Gonadotropic effects of cholera enterotoxin in the rat testis slices: stimulation of adenylate cyclase activity and testosterone synthesis from cholesterol.
Cholera
Gonadotropin and cAMP modulation of IGE binding protein production in ovarian granulosa cells.
Cholera
GTP-activated GTP binding protein(Gs) in membranes achieved by hormone plus GDP does not serve as a substrate for ADP-ribosylation by cholera toxin.
Cholera
GTP-binding proteins and adenylate cyclase activity in v-Ki-ras transformed NIH/3T3 fibroblast cells.
Cholera
GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica.
Cholera
GTP-binding proteins associated with the human placental syncytiotrophoblast plasma membrane.
Cholera
Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts.
Cholera
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Cholera
Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.
Cholera
Guanine nucleotide dependent formation of a complex between choleragen (cholera toxin) a subunit and bovine brain ADP-ribosylation factor.
Cholera
Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.
Cholera
Guanine nucleotide-binding proteins (G proteins) in activation of adenylyl cyclase: lessons learned from cholera and "travelers' diarrhea".
Cholera
Guanosine 5'-O-(2-thiodiphosphate) as a competitive inhibitor of GTP in hormone or cholera toxin-stimulated pancreatic adenylate cyclase.
Cholera
Guanyl nucleotides participate in the beta-adrenergic stimulation of adenylate cyclase activity in the intermediate lobe of the rat pituitary gland.
Cholera
Hemocyte-hemocyte adhesion and nodulation reactions of the greater wax moth, Galleria mellonella are influenced by cholera toxin and its B-subunit.
Cholera
Hepatic adenylate cyclase. Development-dependent coupling to the beta-adrenergic receptor in the neonate.
Cholera
Hepatocyte beta-adrenergic responsiveness and guanine nucleotide-binding regulatory proteins.
Cholera
Heterogeneous Family of Cyclomodulins: Smart Weapons That Allow Bacteria to Hijack the Eukaryotic Cell Cycle and Promote Infections.
Cholera
Heterologous regulations of cAMP responses in pregnant rat myometrium. Evolution from a stimulatory to an inhibitory prostaglandin E2 and prostacyclin effect.
Cholera
Hormone-independent activation of adenylate cyclase in large steroidogenic ovine luteal cells does not result in increased progesterone secretion.
Cholera
Host response to Escherichia coli heat-labile enterotoxin via two microvillus membrane receptors in the rat intestine.
Cholera
Human chorionic gonadotropin-induced heterologous desensitization of rabbit luteal adenylyl cyclase is associated with altered receptor and G-protein function.
Cholera
Human gonadotropin-releasing hormone receptor gene transcription: up-regulation by 3',5'-cyclic adenosine monophosphate/protein kinase A pathway.
Cholera
Human immunoglobulin preparation for intravenous use induces elevation of cellular cyclic adenosine 3':5'-monophosphate levels, resulting in suppression of tumour necrosis factor alpha and interleukin-1 production.
Cholera
Human monocyte killing of Staphylococcus aureus: modulation by agonists of cyclic adenosine 3',5'-monophosphate and cyclic guanosine 3',5'-monophosphate.
Cholera
Hyperpermeability of pulmonary endothelial monolayer: protective role of phosphodiesterase isoenzymes 3 and 4.
Cholera
Hypertrophy of pheochromocytoma cells treated with nerve growth factor and activators of adenylate cyclase.
Cholera
Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells.
Cholera
Identification of receptor regulatory proteins, membrane glycoproteins, and functional characteristics of adenylate cyclase in vesicles derived from the human neutrophil.
Cholera
Identification of the predominant substrate for ADP-ribosylation by islet activating protein.
Cholera
In vitro formation and expansion of cysts derived from human renal cortex epithelial cells.
Cholera
In vivo evidence that lithium inactivates Gi modulation of adenylate cyclase in brain.
Cholera
Inactivation of pertussis toxin-sensitive guanyl nucleotide-binding proteins increase parathyroid hormone receptors and reverse agonist-induced receptor down-regulation in ROS 17/2.8 cells.
Cholera
Increase in stimulatory G protein and glucagon-responsive adenylate cyclase activity in rat liver following partial hepatectomy.
Cholera
Increased adenylate cyclase activity and rapid weight loss following intraseptal injection of cholera toxin.
Cholera
Increased cholera toxin-, and forskolin-induced cyclic AMP accumulations in psoriatic involved versus uninvolved or normal human epidermis.
Cholera
Increased number of beta-adrenoceptors in hepatocytes from rats treated with 2-acetylaminofluorene.
Cholera
Indapamide alters the cyclic AMP signal transduction pathway in cardiomyocytes in culture.
Cholera
Independent regulation of beta-adrenergic receptor and nucleotide binding proteins of adenylate cyclase. Developmental and denervation-dependent responses in rat parotid.
Cholera
Induction of refractoriness to isoproterenol by prior treatment of C6-2B rat astrocytoma cells with cholera toxin.
Cholera
Influence of cholera toxin (an adenylate cyclase activator) on deoxyribonucleic acid synthesis of bovine mammary tissue in vitro and in athymic nude mice.
Cholera
Influence of dietary omega-3 fatty acids on transmembrane signalling in rat submandibular salivary gland.
Cholera
Influences of cholera toxin on thyroid stimulation by thyrotropin and thyroid-stimulating antibody.
Cholera
Inhibition by cholera toxin of rat polymorphonuclear leukocyte chemotaxis demonstrated in vitro and in vivo.
Cholera
Inhibition of acetylcholine release from guinea pig myenteric neurons by neuropeptide Y: GTP-binding protein mediation.
Cholera
Inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor.
Cholera
Inhibition of ADP-ribosyltransferase activity of cholera toxin by MDL 12330A and chlorpromazine.
Cholera
Inhibition of cholera toxin activation of the adenylate cyclase system in intact HeLa cells.
Cholera
Inhibition of cholera toxin-stimulated intestinal epithelial cell adenylate cyclase by adenosine analogs.
Cholera
Inhibition of cyclic AMP formation by iodide in suspension cultures of porcine thyroid follicle cells.
Cholera
Inhibition of denuded mouse oocyte meiotic maturation by forskolin, an activator of adenylate cyclase.
Cholera
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Cholera
Inhibition of gonadotropin-induced granulosa cell differentiation by activation of protein kinase C.
Cholera
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.
Cholera
Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
Cholera
Inhibition of protein phosphatases by okadaic acid and calyculin-A differentially modulates hormonal- and forskolin-stimulated formation of cyclic AMP in AtT-20 corticotrophs: effect of pituitary adenylate activating polypeptide and corticotropin-releasing factor.
Cholera
Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway.
Cholera
Inhibition of the proliferation of Nb2 cells by femtomolar concentrations of cholera toxin and partial reversal of the effect by 12-O-tetradecanoyl-phorbol-13-acetate.
Cholera
Inhibitory effect of cholera toxin on human natural cell-mediated cytotoxicity and its augmentation by interferon.
Cholera
Inhibitory effect of guanyl nucleotides toward adenylate cyclase activity of Chinese hamster ovary cell membranes activated in vitro by cholera toxin.
Cholera
Inhibitory effects of pentacaine and some related local anaesthetics on rat hepatic adenylate cyclase.
Cholera
Inhibitory regulation of adenylyl cyclases. Evidence inconsistent with beta gamma-complexes of Gi proteins mediating hormonal effects by interfering with activation of Gs.
Cholera
Insulin and glucagon attenuate the ability of cholera toxin to activate adenylate cyclase in intact hepatocytes.
Cholera
Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C.
Cholera
Interaction between prostacyclin and cortisol in fetal lung cells: effects on cAMP production.
Cholera
Interaction between the calcium and adenylate cyclase messenger systems in dispersed chief cells from guinea pig stomach. Possible cellular mechanism for potentiation of pepsinogen secretion.
Cholera
Interaction of guanine nucleotides with adenylate cyclase in normal and spontaneously transformed RL-RP-C cloned rat hepatocytes.
Cholera
Interactions of cholera toxin with isolated hepatocytes. Effects of low pH, chloroquine and monensin on toxin internalization, processing and action.
Cholera
Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes.
Cholera
Interleukin 2 counteracts the inhibition of cytotoxic T lymphocytes by cholera toxin in vitro and in vivo.
Cholera
Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.
Cholera
Intestinal resistance to cholera toxin in mouse. Antitoxic antibodies and desensitization of adenylate cyclase.
Cholera
Intrathecally administered cholera toxin blocks allodynia and hyperalgesia in persistent pain models.
Cholera
Involvement of a high-affinity GTPase in the inhibitory coupling of striatal muscarinic receptors to adenylate cyclase.
Cholera
Involvement of cAMP in initiating maturation of the brittle-star Amphipholis kochii oocytes: induction of oocyte maturation by inhibitors of cyclic nucleotide phosphodiesterase and activators of adenylate cyclase.
Cholera
Involvement of cAMP signaling in elicitor-induced phytoalexin accumulation in Cupressus lusitanica cell cultures.
Cholera
Involvement of nicotinamide adenine dinucleotide in the action of cholera toxin in vitro.
Cholera
Involvement of second messenger systems in stimulation of angiotensin converting enzyme of bovine endothelial cells.
Cholera
Involvement of the cAMP messenger system and extracellular Ca(2+) during hyposmotically-induced prolactin release in the Mozambique tilapia.
Cholera
Iron inhibits D-1 dopamine receptor coupled adenylate cyclase via G-proteins in the caudate nucleus of the rat.
Cholera
Is dopamine-sensitive adenylate cyclase involved in regulating the activity of striatal cholinergic neurons?
Cholera
Is the receptor-mediated endocytosis of cholera toxin A pre-requisite for its activation of adenylate cyclase in intact rat hepatocytes?
Cholera
Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
Cholera
Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.
Cholera
Isolation and partial characterization of adenylate cyclase-enriched membranes from human platelets.
Cholera
Isolation of a mutant LLC-PK1 cell line defective in hormonal responsiveness. A pleiotropic lesion in receptor function.
Cholera
Isoproterenol is a positive regulator of the suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes.
Cholera
Kappa opiate agonists inhibit Ca2+ influx in rat spinal cord-dorsal root ganglion cocultures. Involvement of a GTP-binding protein.
Cholera
Kinetics of activation of ADP-ribosylation and adenylate cyclase by cholera toxin in cloned differentiated hepatocytes.
Cholera
Labeling of a GTP-binding regulatory protein of rat brain adenylate cyclase system by cholera toxin-catalyzed ADP-ribosylation.
Cholera
Limulus ventral photoreceptors contain a homologue of the alpha-subunit of mammalian Ns.
Cholera
Lindane decreases forskolin-stimulated cyclic AMP accumulation but does not modify Gs in rat enterocytes.
Cholera
Localization of the action of cholera toxin on adenyl cyclase in mucosal epithelial cells of rabbit intestine.
Cholera
Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system.
Cholera
MaxiK channel mediates beta2-adrenoceptor-activated relaxation to isoprenaline through cAMP-dependent and -independent mechanisms in guinea-pig tracheal smooth muscle.
Cholera
MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms.
Cholera
Mechanism of action of cholera toxin and the mobile receptor theory of hormone receptor-adenylate cyclase interactions.
Cholera
Mechanism of action of cholera toxin on intact cells. Generation of A1 peptide and activation of adenylate cyclase.
Cholera
Mechanism of action of cholera toxin. Specific inhibition of toxin-induced activation of adenylate cyclase.
Cholera
Mechanism of action of cholera toxin: effect of receptor density and multivalent binding on activation of adenylate cyclase.
Cholera
Mechanism of action of Vibrio cholerae enterotoxin. Effects on adenylate cyclase of toad and rat erythrocyte plasma membranes.
Cholera
Mechanism of activation of cholera toxin by ADP-ribosylation factor (ARF): both low- and high-affinity interactions of ARF with guanine nucleotides promote toxin activation.
Cholera
Mechanism of adenylate cyclase activation by cholera toxin: inhibition of GTP hydrolysis at the regulatory site.
Cholera
Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic.
Cholera
Mechanism of cholera toxin action: covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system.
Cholera
Mechanism of cholera toxin activation by a guanine nucleotide-dependent 19 kDa protein.
Cholera
Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.
Cholera
Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes.
Cholera
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX.
Cholera
Mesocestoides lineatus: trypsin induced development to adult mediated by Ca2+ and protein kinase C.
Cholera
Microinjection of a 19-kDa guanine nucleotide-binding protein inhibits maturation of Xenopus oocytes.
Cholera
Mn2+-uncoupling of the catecholamine-sensitive adenylate cyclase system of rat reticulocytes. Parallel effects on cholera toxin-catalyzed ADP-ribosylation of the system.
Cholera
Mode of action of cholera toxin: stabilization of catecholamine-sensitive adenylate cyclase in turkey erythrocytes.
Cholera
Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.
Cholera
Modification of the adenylate cyclase activity of bovine thyroid plasma membranes by manipulating the ganglioside composition with a nonspecific lipid transfer protein.
Cholera
Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation.
Cholera
Modification of TSH-stimulated adenylate cyclase activity of bovine thyroid by manipulation of membrane phospholipid composition with a nonspecific lipid transfer protein.
Cholera
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
Cholera
Modulation of in vitro erythropoiesis: enhancement of erythroid colony growth by cyclic nucleotides.
Cholera
Modulation of intracellular cyclic adenosine monophosphate levels and the differentiation response of human neuroblastoma cells.
Cholera
Modulation of lipoprotein lipase in the intact rat by cholera toxin--an irreversible agonist of cyclic AMP.
Cholera
Modulation of protective immunity against herpes simplex virus via mucosal genetic co-transfer of DNA vaccine with b2-adrenergic agonist.
Cholera
Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I.
Cholera
Molecular cloning, sequence analysis and mRNA expression of human ADP-ribosylation factor.
Cholera
Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways.
Cholera
Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.
Cholera
Multiple signaling pathways of histamine H2 receptors. Identification of an H2 receptor-dependent Ca2+ mobilization pathway in human HL-60 promyelocytic leukemia cells.
Cholera
Multiple signalling pathways involved in beta(2)-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells.
Cholera
Muscarinic cholinergic induced secretin subsensitivity in rat isolated pancreatic acini. Effects on amylase release, cyclic adenosine monophosphate and inositol phosphate formation.
Cholera
Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics.
Cholera
Muscarinic receptor-stimulated phosphoinositide turnover in human SK-N-SH neuroblastoma cells: differential inhibition by agents that elevate cyclic AMP.
Cholera
Mutagenesis of the amino-terminal glycine to alanine in Gs alpha subunit alters beta gamma-dependent properties and decreases adenylylcyclase activation.
Cholera
N-Chloroacetylhydrazone of oxo-GTP irreversibly inhibits the activating function of GTP-binding protein coupled with adenylate cyclase.
Cholera
Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
Cholera
Naturally soluble component(s) that confer(s) guanine nucleotide and fluoride sensitivity to adenylate cyclase.
Cholera
Negative regulation of adipose-expressed galectin-12 by isoproterenol, tumor necrosis factor alpha, insulin and dexamethasone.
Cholera
Nerve growth factor is a potent inducer of proliferation and neuronal differentiation for adult rat chromaffin cells in vitro.
Cholera
Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.
Cholera
Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+ -dependent adenylyl cyclase(s).
Cholera
Nitroimidazole derivatives inhibit anterior pituitary cell function apparently by a direct effect on the catalytic subunit of the adenylate cyclase holoenzyme.
Cholera
Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture.
Cholera
Norepinephrine infusions increase adenylate cyclase responsiveness in brown adipose tissue.
Cholera
Nucleotide binding and cofactor activities of purified bovine brain and bacterially expressed ADP-ribosylation factor.
Cholera
Olfactory GTP-binding protein: signal-transducing polypeptide of vertebrate chemosensory neurons.
Cholera
Ontogeny of insulin and glucagon receptors and the adenylate cyclase system in guinea pig liver.
Cholera
Opiate-inhibited adenylate cyclase in rat brain membranes depleted of Gs-stimulated adenylate cyclase.
Cholera
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Cholera
Opposing regulatory effects of protein kinase C on the cAMP cascade in human HL-60 promyelocytic leukemia cells.
Cholera
p38 mitogen-activated protein (MAP) kinase but not p44/p42 MAP kinase is involved in prostaglandin E1-induced vascular endothelial growth factor synthesis in osteoblasts.
Cholera
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice.
Cholera
Partial characterization of human spermatozoal phosphodiesterase and adenylate cyclase and the effect of steroids on their activities.
Cholera
Partial purification of a water-soluble liver protein that regulates adenylate cyclase activity (basal, hormone- and cholera-toxin-activated) and cholera-toxin-catalyzed ADP-ribosylation of the membrane G protein.
Cholera
Partial reversal of doxorubicin resistance by forskolin and 1,9-dideoxyforskolin in murine sarcoma S180 variants.
Cholera
Participation of a guanine nucleotide-binding protein cascade in cholera toxin activation of adenylate cyclase.
Cholera
Pathogenesis of Salmonella-mediated intestinal fluid secretion. Activation of adenylate cyclase and inhibition by indomethacin.
Cholera
Peptide mapping of adenylate cyclase regulatory proteins that are cholera toxin substrates.
Cholera
Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus.
Cholera
Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
Cholera
Pertussis toxin prevents homologous desensitization of adenylate cyclase in cultured renal epithelial cells.
Cholera
Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells.
Cholera
PGE2, forskolin, and cholera toxin interactions in rabbit cortical collecting tubule.
Cholera
Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Cholera
Pharmacological elevation of cyclic AMP and transmitter release at the mouse neuromuscular junction.
Cholera
Pharmacological regulation in vitro of meiotic resumption in oocytes of Xenopus laevis.
Cholera
Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells.
Cholera
Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells).
Cholera
Phorbol esters inhibit adenylate cyclase activity in cultured collecting tubular cells.
Cholera
Plasma hyperosmolality increases G protein and 3',5'-cyclic adenosine monophosphate synthesis in the paraventricular and supraoptic nuclei.
Cholera
Plasma membrane Na+/H+ exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways.
Cholera
Plasma membrane-associated component(s) that confer(s) cholera toxin sensitivity to adenylate cyclase.
Cholera
Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters.
Cholera
Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cells.
Cholera
Possible involvement of inhibitory GTP binding regulatory protein in alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase activity in cerebral cortical membranes of rats.
Cholera
Pregnancy-related modifications of rat myometrial Gs proteins: ADP ribosylation, immunoreactivity and gene expression studies.
Cholera
Progestin signaling through an olfactory G protein and membrane progestin receptor-alpha in Atlantic croaker sperm: potential role in induction of sperm hypermotility.
Cholera
Prolactin and MA-10 Leydig cell steroidogenesis: biphasic effects of prolactin and signal transduction.
Cholera
Prolonged stimulation of adenylate cyclase activity and testosterone production by cholera enterotoxin with suppression of gonadotropin release in rats.
Cholera
Properties of adenyl cyclase from human jejunal mucosa during naturally acquired cholera and convalescence.
Cholera
Properties of adenylate cyclase in mucosal cells of the rabbit ileum and the effect of cholera toxin.
Cholera
Properties of cholera toxin- and NaF-stimulated adenylate cyclase from mouse thymocytes.
Cholera
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Cholera
Properties of protein kinase and adenylate cyclase-deficient variants of a macrophage-like cell line.
Cholera
Properties of rat erythrocyte membrane cytoskeletal structures produced by digitonin extraction: digitonin-insoluble beta-adrenergic receptor, adenylate cyclase, and cholera toxin substrate.
Cholera
Prostaglandin E in cholera toxin-induced intestinal secretion. Lack of an intermediary role.
Cholera
Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Cholera
Prostaglandin E-induced heterologous desensitization of hepatic adenylate cyclase. Consequences on the guanyl nucleotide regulatory complex.
Cholera
Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia.
Cholera
Prostaglandin E2, adenosine 3':5'-cyclic monophosphate and changes in endometrial vascular permeability in rat uteri sensitized for the decidual cell reaction.
Cholera
Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes.
Cholera
Protection against experimental cholera in the rat. A study on the formation of antibodies against cholera toxin and desensitization of adenylate cyclase after immunization with cholera toxin.
Cholera
Protein kinase A activity modulates natriuretic peptide-dependent cGMP accumulation in renal cells.
Cholera
Protein kinase C activation enhances cAMP accumulation in Swiss 3T3 cells: inhibition by pertussis toxin.
Cholera
Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.
Cholera
Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium.
Cholera
Protein kinase C-dependent modulation of stimulatory guanine nucleotide binding protein of fetal rat skin keratinocytes.
Cholera
Protein synthesis is required for cholera toxin-induced stimulation of arachidonic acid metabolism.
Cholera
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin.
Cholera
Raised cyclic-AMP and a small applied electric field influence differentiation, shape, and orientation of single myoblasts.
Cholera
Rat kidney cells in primary culture: hormone-mediated desensitization of the adenosine 3',5'-monophosphate response to parathyroid hormone and calcitonin.
Cholera
Rat pancreas adenylate cyclase. III. Its role in pancreatic secretion assessed by means of choleara toxin.
Cholera
Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice.
Cholera
Receptor-independent activation of cardiac adenylyl cyclase by GDP and membrane-associated nucleoside diphosphate kinase. A new cardiotonic mechanism?
Cholera
Receptors for N-acetylated sugars may stimulate adenylate cyclase to sensitize and tune mechanoreceptors involved in triggering nematocyst discharge.
Cholera
Recombinant nontoxinogenic Vibrio cholerae strains as attenuated cholera vaccine candidates.
Cholera
Reconstitution of a hormone-sensitive adenylate cyclase with membrane extracts from Neurospora and avian erythrocytes.
Cholera
Redox modulation of Gi protein expression and adenylyl cyclase signaling: role of nitric oxide.
Cholera
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Cholera
Reduction of adenylyl cyclase activity by cholera toxin in myeloid cells. Long-term down-regulation of Gs alpha subunits by cholera toxin treatment.
Cholera
Regulation by butyrate of the cAMP response to cholera toxin and forskolin in pituitary GH1 cells.
Cholera
Regulation by forskolin of octopamine-stimulated adenylate cyclase from brain of the dipterous Ceratitis capitata.
Cholera
Regulation of adenosine 3':5'-monophosphate content of rous sarcoma virus-transformed human astrocytoma cells. Effects of cholera toxin on the responsiveness to catecholamines and prostaglandins.
Cholera
Regulation of aqueous flow by the adenylate cyclase receptor complex in the ciliary epithelium.
Cholera
Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells.
Cholera
Regulation of differentiation of the BC3H1 muscle cell line through cAMP-dependent and -independent pathways.
Cholera
Regulation of G-proteins in differentiation. Altered ratio of alpha- to beta-subunits in 3T3-L1 cells.
Cholera
Regulation of Ig-induced eosinophil degranulation by adenosine 3',5'-cyclic monophosphate.
Cholera
Regulation of insulin-like growth factor-binding protein-1 production in human granulosa-luteal cells.
Cholera
Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
Cholera
Regulation of oocyte maturation in the rainbow trout,Salmo gairdneri: role of cyclic AMP in the mechanism of action of the maturation inducing steroid (MIS), 17?-hydroxy, 20?-dihydroprogesterone.
Cholera
Regulation of parathyroid hormone messenger RNA levels by protein kinase A and C in bovine parathyroid cells.
Cholera
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells.
Cholera
Regulation of the in vitro early anamnestic antibody response by exogenous cholera enterotoxin and cyclic AMP.
Cholera
Regulation of the ovalbumin gene: effects of insulin, adenosine 3',5'-monophosphate, and estrogen.
Cholera
Regulation of the transmodulated epidermal growth factor receptor by cholera toxin and the protein phosphatase inhibitor okadaic acid.
Cholera
Relationship between the self-incompatibility and cAMP level in Lilium longiflorum.
Cholera
Release of phospholipase A2 activity from rat vascular smooth muscle cells mediated by cAMP.
Cholera
Requirement for guanosine triphosphate for cholera-toxin-catalysed incorporation of adenosine diphosphate ribose into rat liver plasma membranes and for activation of adenylate cyclase.
Cholera
Requirement for guanosine triphosphate in the activation of adenylate cyclase by cholera toxin.
Cholera
Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.
Cholera
Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase.
Cholera
Restoration of glucagon responsiveness in spontaneously transformed rat hepatocytes (RL-PR-C) by fusion with normal progenitor cells and rat liver plasma membranes.
Cholera
Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK).
Cholera
Reticulocyte cytosol activator protein: its actions upon the beta adrenergic receptor and the N-proteins of adenylate cyclase.
Cholera
Robust sensitization to amphetamine following intra-VTA cholera toxin administration.
Cholera
Role of cyclic adenosine monophosphate in the induction of endothelial barrier properties.
Cholera
Role of cyclic nucleotides in the inhibition of growth-hormone secretion by somatostatin.
Cholera
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Cholera
Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle.
Cholera
Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye.
Cholera
Role of guanine nucleotides in the stimulation of thyroid adenylate cyclase by prostaglandin E1 and cholera toxin.
Cholera
Selective effects of cholera toxin on the adrenaline responsive component of hepatic adenyl cyclase.
Cholera
Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
Cholera
Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoparan and cAMP.
Cholera
Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha.
Cholera
Separation and properties of a regulatory GTPase activity associated with the adenylate cyclase system in rat brain synaptic plasma membranes.
Cholera
Separation and reconstitution of regulatory and catalytic components of heart adenylate cyclase.
Cholera
Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins.
Cholera
Shapes of cells spreading on fibronectin: measurement of the stellation of BHK21 cells induced by raising cyclic AMP, and of its reversal by serum and lysophosphatidic acid.
Cholera
Short communications. Subunit A from cholera toxin is an activator of adenylate cyclase in pigeon erythrocytes.
Cholera
Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine.
Cholera
Signal transduction by cholera toxin: processing in vesicular compartments does not require acidification.
Cholera
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Cholera
Signs of endolymphatic hydrops after perilymphatic perfusion of the guinea pig cochlea with cholera toxin; a pharmacological model of acute endolymphatic hydrops.
Cholera
Similarities and differences in phorbol ester- and luteinizing-hormone-induced desensitization of rat tumour Leydig-cell adenylate cyclase.
Cholera
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Cholera
Site-directed mutagenic alteration of potential active-site residues of the A subunit of Escherichia coli heat-labile enterotoxin. Evidence for a catalytic role for glutamic acid 112.
Cholera
Small fragments from the A subunit of cholera toxin capable of activating adenylate cyclase.
Cholera
Soluble guanine nucleotide-dependent ADP-ribosylation factors in activation of adenylyl cyclase by cholera toxin.
Cholera
Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP.
Cholera
Somatostatin inhibits cAMP-mediated cholinergic transmission in the myenteric plexus.
Cholera
Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.
Cholera
Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat.
Cholera
Specificity of cytochemical demonstration of adenylate cyclase in liver using adenylate-(beta, gamma-methylene) diphosphate as substrate.
Cholera
Spin-labeled stearates as probes for microenvironment of murine thymocyte adenylate cyclase-cyclic adenosine 3':5'-monophosphate system.
Cholera
Spontaneous Intracellular Calcium Oscillations and G(s) ? Subunit Expression are Inversely Correlated with Secretory Granule Content in Pituitary Cells.
Cholera
Stepwise activation of the gonadotropic signal transduction pathway, and the ability of prostaglandin F2alpha to inhibit this activated pathway.
Cholera
Stimulation by cholera toxin of ADP-ribosylation of membrane proteins, adenylate cyclase and insulin release in pancreatic islets.
Cholera
Stimulation of adenylate cyclase in washed pigeon erythrocyte membrane with cholera toxin and its subunits.
Cholera
Stimulation of calcium influx and calcium cascade by cyclic AMP in cultured carrot cells.
Cholera
Stimulation of epinephrine-sensitive fat cell adenylate cyclase by cytosol: effect of cholera toxin.
Cholera
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins.
Cholera
Stimulation of slow action potentials in guinea pig papillary muscle cells by intracellular injection of cAMP, Gpp(NH)p, and cholera toxin.
Cholera
Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium.
Cholera
Stimulatory and inhibitory effects of forskolin on adenylate cyclase in rat normal hepatocytes and hepatoma cells.
Cholera
Stimulatory and inhibitory effects of sodium salts on adenylate cyclase of rat liver. Implications for salt modulation of guanine nucleotide-binding regulatory component function.
Cholera
Stimulatory guanine nucleotide binding protein in pig epidermis: transient increase of the 45KDA cholera toxin substrate (Gs alpha) in the tape stripping-induced hyperproliferative state.
Cholera
Streptozotocin-induced diabetes impairs G-protein linked signal transduction in vascular smooth muscle.
Cholera
Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells.
Cholera
Studies of cAMP metabolism in cultured hepatoma cells: presence of functional adenylate cyclase despite low cAMP content and lack of hormonal responsiveness.
Cholera
Studies on the mechanism of the decreased guanine nucleotide stimulatory effects on adenylate cyclase after adrenalectomy in rat adipocytes.
Cholera
Studies on the mechanisms of somatostatin action on insulin release. IV. effect of somatostatin on cyclic AMP levels and phosphodiesterase activity in isolated rat pancreatic islets.
Cholera
Studies on the mode of action of cholera toxin. Effects on solubilized adenylate cyclase.
Cholera
Studies on the time course and rate-limiting steps in the activation of adenylate cyclase in rat liver by cholera toxin.
Cholera
Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.
Cholera
Suppression of aquaporin adipose gene expression by isoproterenol, TNFalpha, and dexamethasone.
Cholera
Synthesis of a photoreactive, radiolabelled derivative of the oligosaccharide of GM1 ganglioside.
Cholera
Synthesis of interleukin 6 (interferon-beta 2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP.
Cholera
Synthetic peptides corresponding to human follicle-stimulating hormone (hFSH)-beta-(1-15) and hFSH-beta-(51-65) induce uptake of 45Ca++ by liposomes: evidence for calcium-conducting transmembrane channel formation.
Cholera
Systematic shut-off of the hormone receptors in intraspecific adrenal x Leydig cell hybrids.
Cholera
The 5'-flanking region of the human P-450(SCC) gene shows responsiveness to cAMP-dependent regulation in a transient gene-expression system of Y-1 adrenal tumor cells.
Cholera
The activation of adenylate cyclase by cholera toxin: possible interaction with the nucleotide regulatory site.
Cholera
The activation of adenylate cyclase from small intestinal epithelium by cholera toxin.
Cholera
The adenylate cyclase system and calcitonin secretion from perfused dog thyroid lobes.
Cholera
The B subunit of cholera toxin enhances DNA synthesis in rat hepatocytes induced by insulin and epidermal growth factor.
Cholera
The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.
Cholera
The biological activity of bovine and human thyrotropin is differently affected by trypsin treatment of human thyroid cells: thyroid-stimulating antibody is related to human thyrotropin.
Cholera
The catalytic unit of ram sperm adenylate cyclase can be activated through the guanine nucleotide regulatory component and prostaglandin receptors of human erythrocyte.
Cholera
The differential detergent solubilization of adenylate cyclase and polypeptides ADP-ribosylated with cholera toxin suggests an excess of G/F protein relative to adenylate cyclase in rat pancreatic plasma membranes.
Cholera
The effect of streptozotocin diabetes on the vasoactive intestinal peptide receptor/effector system in membranes from rat ventral prostate.
Cholera
The effects of hormones, cholera toxin, and N alpha-tosyl-L-lysine chloromethyl ketone on adenylate cyclase in viable granulosa cells.
Cholera
The effects of retinoic acid on the in vitro and in vivo growth of neuroblastoma cells.
Cholera
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
Cholera
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
Cholera
The immunologic control mechanism against cholera toxin. II. Stimulation of adenylate cyclase without fluid secretion.
Cholera
The influence of EDTA on adenylate cyclase activity in membranes from rat and mouse myocardium.
Cholera
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein.
Cholera
The regulation of steroidogenesis is different in the two types of ovine luteal cells.
Cholera
The role of calmodulin in the responses to adrenocorticotropin of plasma membranes from adrenal cells.
Cholera
The role of G-proteins in the mitogenesis of rat lactogen-dependent and lactogen-independent Nb2 lymphoma cells.
Cholera
The role of the guanine nucleotide exchange reaction in the regulation of the beta-adrenergic receptor and in the actions of catecholamines and cholera toxin on adenylate cyclase in turkey erythrocyte membranes.
Cholera
The sites on the regulatory component of adenylate cyclase which are ADP-ribosylated by cholera toxin.
Cholera
The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I.
Cholera
The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.
Cholera
The stimulatory guanine-nucleotide regulatory unit of adenylate cyclase from bovine cerebral cortex. ADP-ribosylation and purification.
Cholera
The synaptic structure of PACAP immunoreactive axons in the intermediolateral nucleus of the rat.
Cholera
Thermodependence of guanine nucleotide-activated rat cardiac adenylate cyclase activity. Effect of cholera toxin pretreatment.
Cholera
Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.
Cholera
Thyroid membrane ADP ribosyltransferase activity. Stimulation by thyrotropin and activity in functioning and nonfunctioning rat thyroid cells in culture.
Cholera
Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
Cholera
Thyrotropin stimulation of the ADP-ribosyltransferase activity of bovine thyroid membranes.
Cholera
Tissue and species distribution of mRNA encoding two ADP-ribosylation factors, 20-kDa guanine nucleotide binding proteins.
Cholera
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
Cholera
Transforming growth factor-beta modulates receptor binding of calciotropic hormones and G protein-mediated adenylate cyclase responses in osteoblast-like cells.
Cholera
Transient and steady state kinetics of the interaction of guanyl nucleotides with the adenylyl cyclase system from rat liver plasma membranes. Interpretation in terms of a simple two-state model.
Cholera
Translocation of alpha subunits of stimulatory guanine nucleotide-binding proteins through stimulation of the prostacyclin receptor in mouse mastocytoma cells.
Cholera
Transport of bacterial toxins into target cells: pathways followed by cholera toxin and botulinum progenitor toxin.
Cholera
Treatment of cardiac myocytes with 8-(4-chlorophenylthio)-adenosine 3',5'-cyclic monophosphate, forskolin or cholera toxin does not stimulate cellular or heparin-releasable lipoprotein lipase activities.
Cholera
Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms.
Cholera
Triiodothyronine modulates interleukin-6 synthesis in osteoblasts: inhibitions in protein kinase A and C pathways.
Cholera
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Cholera
Type II heat-labile enterotoxins from 50 diverse Escherichia coli isolates belong almost exclusively to the LT-IIc family and may be prophage encoded.
Cholera
Uncoupling of alpha-adrenoceptor-mediated inhibition of human platelet adenylate cyclase by N-ethylmaleimide.
Cholera
Unique properties of the follicle-stimulating hormone- and cholera toxin-sensitive adenylyl cyclase of immature granulosa cells.
Cholera
Unusual antagonistic actions of mixtures of vasoactive intestinal peptide, thyroid-stimulating antibodies, and cholera toxin on adenosine 3',5'-monophosphate accumulation in normal human thyroid cell cultures.
Cholera
Up-regulation of beta 2-adrenergic receptors in previously transplanted, denervated nonfailing human hearts.
Cholera
Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride.
Cholera
Vibrio cholerae Infection of Drosophilamelanogaster Mimics the Human Disease Cholera.
Cholera
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Cholera
Voltage-sensitive adenylyl cyclase activity in cultured neurons. A calcium-independent phenomenon.
Cholera
[Adenylate cyclase system responsive to thyroid stimulating hormone (TSH) of porcine thyroid cells in primary monolayer cultures. Potential effect of forskolin on TSH-mediated adenylate cyclase stimulation]
Cholera
[Decrease in the lipid content of human atherosclerotic aorta cells as affected by compounds increasing the intracellular level of cyclic AMP]
Cholera
[Effect of genotype and social stress on cAMP- and substrate-dependent mechanisms of regulating hormonal function of testis in mice]
Cholera
[Electron microscopic demonstration of adenylate cyclase in rabbit small intestine enterocytes doubly stimulated by cholera toxin and sodium fluoride]
Cholera
[Mechanisms of diabetes-induced impairements of serotonin release from rat brain synaptosomes: effect of nicotinamide]
Cholera
[Possible trophic role on the neuromuscular junction of a neuropeptide co-existing with acetylcholine in motor neurons of the spinal cord]
Cholera
[Response of the IRD intestinal epithelial cell line to Clostridium difficile toxins A and B in rats. Effect of Saccharomyces boulardii]
Cholera
[Response to cholera toxin of 2 epithelial intestinal cell lines. Effect of Saccharomyces boulardii]
Cholera
[Sodium 2,3-dithiopropanesulfate blockade of the effect of cholera enterotoxin on adenylate cyclase and the concentration of cyclic 3',5'-adenosine monophosphate in the small intestine mucosa of the rabbit]
Cholera
[Stimulatory effects of follicular stimulating hormone on the proliferation of ovarian cancer cell line in vitro and in vivo]
Cholera
[Study of molecular mechanisms of the relaxin action on adenylyl cyclase signaling system using synthetic peptides derived from the relaxin receptor LGR7]
Cholera
[The effect of sodium and ouabain on the activation of beta 2-adrenoreceptor-dependent adenylate cyclase in human lymphocytes]
Cholera
[The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria]
Cholera
[The measurement of N-protein activity in plasma membranes: the comparison of assay methods by reconstitution of cyc- membranes and cholera toxin-catalyzed ADP ribosylation]
Cholera
[The role of signal transduction systems in the regulation of production and secretion of TA-4 by cultured cervical epidermoid carcinoma cells (CaSki)]
Cholera
[The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)]
Cholera
[Ultrastructural changes in rat colon epitheliocytes after treatment with cholera toxin]
Chorea
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Chorea
Methylphenidate Can Improve Chorea in NKX2.1 and ADCY5 Mutation-positive Patients-A Report of Two Children.
Chorea
Recurrent ADCY5 Mutation in Mosaic Form with Nocturnal Paroxysmal Dyskinesias and Video Electroencephalography Documentation of Dramatic Response to Caffeine Treatment.
Chorea
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
Choriocarcinoma
12-O-tetradecanoyl phorbol-13-acetate potentiates adenosine 3',5'-monophosphate-mediated chorionic gonadotropin secretion by cultured human choriocarcinoma cells.
Choriocarcinoma
Effect of human parathyroid hormone on the cAMP production and the endocrine functions of trophoblast cells from first trimester placenta.
Choriocarcinoma
Effects of pituitary adenylate cyclase activating polypeptide on the survival and signal transduction pathways in human choriocarcinoma cells.
Choriocarcinoma
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Choriocarcinoma
Interplay of cAMP and MAPK pathways in hCG secretion and fusogenic gene expression in a trophoblast cell line.
Choriocarcinoma
Modulation of steroidogenesis in choriocarcinoma cells by cholera toxin, phorbol ester, epidermal growth factor and insulin-like growth factor I.
Choriocarcinoma
PACAP-38 positively regulates glycoprotein hormone alpha-gene expression in placental cells.
Choriocarcinoma
Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells.
Choriocarcinoma
Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells.
Choriocarcinoma
Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone alpha subunit gene by epidermal growth factor and forskolin.
Choriocarcinoma
[The role of signal transduction systems in the regulation of the production and secretion of hCG (alpha, beta) by cultured human choriocarcinoma cells (BeWo)]
Classical Lissencephalies and Subcortical Band Heterotopias
Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study.
Cleft Palate
Developmental pattern of cAMP, adenyl cyclase, and cAMP phosphodiesterase in the palate, lung, and liver of the fetal mouse: alterations resulting from exposure to methylmercury at levels inhibiting palate closure.
Cleft Palate
In vitro activation of adenylate cyclase by parathyroid hormone and calcitonin during normal and hydrocortisone-induced cleft palate development in the golden hamster.
Cleidocranial Dysplasia
The new bone biology: pathologic, molecular, and clinical correlates.
Colitis
Adenylyl cyclase 6 is involved in the hyposecretory status of experimental colitis.
Colitis
Defective stimulation of cyclic AMP by prostaglandin E2 in colonic epithelial cells in colitis.
Colitis, Ulcerative
Inactivation of the G alpha i2 and G alpha o genes by homologous recombination.
Colitis, Ulcerative
Increased colonic adenylate cyclase activity in active ulcerative colitis.
Colonic Neoplasms
Adenylate cyclase activity and cyclic adenosine monophosphate levels in colon cancer lines and dermal fibroblasts and the effects of cholera toxin and epidermal growth factor.
Colonic Neoplasms
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Colonic Neoplasms
Development of vasoactive intestinal peptide-responsive adenylate cyclase during enterocytic differentiation of Caco-2 cells in culture. Evidence for an increased receptor level.
Colonic Neoplasms
Effects of alpha 2-adrenergic agonist preincubation on subsequent forskolin-stimulated adenylate cyclase activity and [3H]forskolin binding in membranes from HT29 cells.
Colonic Neoplasms
Elevated Adenylyl Cyclase 9 Expression Is a Potential Prognostic Biomarker for Patients with Colon Cancer.
Colonic Neoplasms
Long non-coding RNA DPP10-AS1 exerts anti-tumor effects on colon cancer via the upregulation of ADCY1 by regulating microRNA-127-3p.
Colorectal Neoplasms
Hormonal regulation of adenylate cyclase activity in circulating lymphocytes and its interrelationship with hormone sensitivity of tumor tissue in colorectal cancer patients.
Colorectal Neoplasms
[Characteristics of the hormonal metabolic status of patients with colonic and rectal cancer]
Colorectal Neoplasms
[The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine]
Congenital Hypothyroidism
Comparative study of collecting tubules and vasopressin binding capacity in the renal medulla of developing hypothyroid rat.
Congenital Hypothyroidism
Use of FRTL-5 for the study of thyroid antibodies involved in goitrogenesis.
Contracture
cAMP-dependent reduction in membrane fluxes during relaxation of arterial smooth muscle.
Contracture
Effects of adenylate cyclase activators on porcine skeletal muscle in malignant hyperpyrexia.
Contracture
Effects of cAMP and forskolin on caffeine-induced contractures and myofilament Ca-sensitivity in saponin-treated rat ventricular trabeculae.
Corneal Injuries
The PACAP-derived peptide MPAPO facilitates corneal wound healing by promoting corneal epithelial cell proliferation and trigeminal ganglion cell axon regeneration.
Coronary Artery Disease
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
Coronary Artery Disease
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
Coronary Disease
Effects of beta blocking agents on the density of beta adrenoceptors and adenylate cyclase response in human myocardium: intrinsic sympathomimetic activity favours receptor upregulation.
Coronary Disease
Effects of beta-adrenergic stimulating and blocking agents on the adrenaline response and adenyl cyclase activity of leukocyte in monkey and human being.
Coronary Occlusion
Forskolin potentiates myocardial reactive hyperaemia in the open chest dog: the contribution of adenylate cyclase.
Coronary Stenosis
Coronary artery stenosis in rats affects beta-adrenergic receptor signaling in myocytes.
Cough
BspR/BtrA, an Anti-? Factor, Regulates the Ability of Bordetella bronchiseptica To Cause Cough in Rats.
Cough
Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin.
Creutzfeldt-Jakob Syndrome
Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain.
Cryptorchidism
Changes in germ cell adenylate cyclase and protein carboxyl methylase activities in rat testicular tissue during bilateral cryptorchidism and after orchidopexy.
Cryptorchidism
Changes in isoproterenol-stimulated adenylate cyclase activity in rat testicular tissue during cryptorchidism and after orchidopexy.
Cryptorchidism
Changes in rat testicular adenylate cyclase activities and gonadotrophin binding during unilateral experimental cryptorchidism.
Cryptorchidism
Germ cell adenylyl cyclase activity in the human undescended testis and the effect of HCG-treatment.
Cryptorchidism
Less calcium in cremaster muscles of boys with undescended testis supports a deficiency in sympathetic innervation.
Cushing Syndrome
cAMP pathway alterations from the cell surface to the nucleus in adrenocortical tumors.
Cushing Syndrome
Multiple hormone receptors in the adenylate cyclase of human adrenocortical tumors.
Cystic Fibrosis
AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera.
Cystic Fibrosis
Combinatorial effects of genistein and sex-steroids on the level of cystic fibrosis transmembrane regulator (CFTR), adenylate cyclase (AC) and cAMP in the cervix of ovariectomised rats.
Cystic Fibrosis
Corrigendum to "Testosterone regulates levels of cystic fibrosis transmembrane regulator, adenylate cyclase and cAMP in the seminal vesicles of orchidectomized rats" [Theriogenology 85(2) (2016) 238-246].
Cystic Fibrosis
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
Cystic Fibrosis
Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation.
Cystic Fibrosis
Detection of adenylate cyclase-coupled receptors in Xenopus oocytes by coexpression with cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes.
Cystic Fibrosis
Estrogen and progesterone differentially regulate the levels of cystic fibrosis transmembrane regulator (CFTR), adenylate cyclase (AC), and cyclic adenosine mono-phosphate (cAMP) in the rat cervix.
Cystic Fibrosis
Extracts from peppermint leaves, lemon balm leaves and in particular angelica roots mimic the pro-secretory action of the herbal preparation STW 5 in the human intestine.
Cystic Fibrosis
GABA induces thee differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8.
Cystic Fibrosis
HCO(3)(-)-dependent soluble adenylyl cyclase activates cystic fibrosis transmembrane conductance regulator in corneal endothelium.
Cystic Fibrosis
Increased expression of G protein-coupled receptor kinases in cystic fibrosis lung.
Cystic Fibrosis
Isobutylmethylxanthine fails to stimulate chloride secretion in cystic fibrosis airway epithelia.
Cystic Fibrosis
Isoproterenol-induced desensitization of mucin release in isolated rat submandibular acini.
Cystic Fibrosis
Lymphocyte and granulocyte phosphatidylethanolamine N-methyltransferase: properties and activity in cystic fibrosis.
Cystic Fibrosis
Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation.
Cystic Fibrosis
NO inhibits signal transduction pathway for ATP release from erythrocytes via its action on heterotrimeric G protein Gi.
Cystic Fibrosis
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel.
Cystic Fibrosis
Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi.
Cystic Fibrosis
Spermine and spermidine, modulators of the cell surface enzyme adenylate cyclase.
Cystic Fibrosis
Testosterone regulates levels of cystic fibrosis transmembrane regulator, adenylate cyclase, and cAMP in the seminal vesicles of orchidectomized rats.
Cystic Fibrosis
The multi-herbal drug STW 5 (Iberogast(R)) has prosecretory action in the human intestine.
Cystic Fibrosis
THE SHARK RECTAL GLAND MODEL: A CHAMPION OF RECEPTOR MEDIATED CHLORIDE SECRETION THROUGH CFTR.
Cystitis
Cyclophosphamide cystitis as a model of visceral pain in rats: a c-fos and Krox-24 study at telencephalic levels, with a note on pituitary adenylate cyclase activating polypeptide (PACAP).
Cysts
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Cysts
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.
Cysts
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway.
Cysts
Changes in the cellular phenotype and extracellular matrix during progression of estrogen-induced mesenchymal kidney tumors in Syrian hamsters.
Cysts
In vitro formation and expansion of cysts derived from human renal cortex epithelial cells.
Cysts
The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease.
Cysts
The secretion of fluid by renal cysts from patients with autosomal dominant polycystic kidney disease.
Darier Disease
Human skin epidermal adenylate cyclase systems: defective beta-adrenergic responsiveness in the involved epidermis of Darier's disease.
Dehydration
A novel role for endogenous pituitary adenylate cyclase activating polypeptide in the magnocellular neuroendocrine system.
Dementia
Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected.
Dementia
Age related decline in aluminum-activated human platelet adenylate cyclase: post-receptor changes in cyclic AMP second messenger signal amplification in normal aging and dementia of the Alzheimer type.
Dementia
Ca2+/CaM-sensitive adenylyl cyclase activity is decreased in the Alzheimer's brain: possible relation to type I adenylyl cyclase.
Dementia
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Dementia
VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by Alzheimer's disease/senile dementia of the Alzheimer type.
Dementia, Vascular
[The changes of cAMP and adenylyl cyclase mRNA level in hippocampus of mice with ischemia/reperfusion].
Demyelinating Diseases
In vivo and in vitro models of demyelinating disease: activation of the adenylate cyclase system influences JHM virus expression in explanted rat oligodendrocytes.
Dermatitis, Atopic
Adenylate cyclase activity in mononuclear leucocytes from patients with atopic dermatitis.
Dermatitis, Atopic
Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis.
Dermatitis, Atopic
Impaired lymphocyte cyclic adenosine monophosphate responses in atopic eczema.
Dermatitis, Atopic
Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis.
Dermatitis, Atopic
Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IgE negative B cells from patients with atopic dermatitis.
Dermatitis, Atopic
Relationship between increased cyclic AMP-phosphodiesterase activity and abnormal adenylyl cyclase regulation in leukocytes from patients with atopic dermatitis.
Dermatitis, Atopic
The adenyl cyclase of skin. II. Adenyl cyclase levels in atopic dermatitis.
Diabetes Insipidus
Alterations in Cyclic AMP Concentration and Adenylate Cyclase Activity in Specific Brain Areas of Rats with Inherited Hypothalamic Diabetes Insipidus (Brattleboro Rats).
Diabetes Insipidus
Influence of chronic ADH treatment on adenylate cyclase and ATPase activity in distal nephron segments of diabetes insipidus Brattleboro rats.
Diabetes Insipidus
Renal medullary adenylate cyclase in rats with hypothalamic diabetes insipidus.
Diabetes Insipidus
Stability of the vasopressin V2 receptor-adenylyl cyclase system in rat kidney.
Diabetes Insipidus, Nephrogenic
Cyclic AMP responses to parathyroid hormone and glucagon during lithium treatment.
Diabetes Insipidus, Nephrogenic
Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity.
Diabetes Insipidus, Nephrogenic
Impairment of cyclic AMP response to bovine parathyroid hormone in patients on chronic lithium therapy with diminished renal urine-concentrating ability.
Diabetes Insipidus, Nephrogenic
Interactions between angiotensin II and arginine vasopressin in water homeostasis.
Diabetes Insipidus, Nephrogenic
Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase.
Diabetes Insipidus, Nephrogenic
Renal medullary adenylate cyclase in drug-induced nephrogenic diabetes insipidus.
Diabetes Insipidus, Nephrogenic
Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus.
Diabetes Insipidus, Nephrogenic
The effect of gentamicin on antidiuretic hormone-stimulated osmotic water flow in the toad urinary bladder.
Diabetes Insipidus, Nephrogenic
Thyroid function and urine-concentrating ability during lithium treatment.
Diabetes Mellitus
Beta-adrenergic receptor activity of cerebral microvessels in experimental diabetes mellitus.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus
Changes in renal phospholipid fatty acids in diabetes mellitus: correlation with changes in adenylate cyclase activity.
Diabetes Mellitus
Decrease in functional activity of G-proteins hormone-sensitive adenylate cyclase signaling system, during experimental type II diabetes mellitus.
Diabetes Mellitus
Desensitization of the adipocyte A(1) adenosine receptor during untreated experimental diabetes mellitus.
Diabetes Mellitus
Effect of diabetes mellitus on responses of the rat basilar artery to activation of beta-adrenergic receptors.
Diabetes Mellitus
Effect of long-term and short-term diabetes on the parathyroid hormone sensitive rat renal adenylate cyclase: correlation with vitamin D metabolism.
Diabetes Mellitus
Functional coupling of hormone receptors with G proteins in the adenylate cyclase system of the rat muscle tissues and brain under conditions of short-term hyperglycemia.
Diabetes Mellitus
Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.
Diabetes Mellitus
Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.
Diabetes Mellitus
Streptozotocin-induced diabetes produces alterations in adenylate cyclase in rat cerebrum, cerebral microvessels and retina.
Diabetes Mellitus
The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects.
Diabetes Mellitus
The Functional State of Hormone-Sensitive Adenylyl Cyclase Signaling System in Diabetes Mellitus.
Diabetes Mellitus
The influence of bromocryptine treatment on activity of the adenylyl cyclase system in the brain of rats with type 2 diabetes mellitus induced by high-fat diet.
Diabetes Mellitus
[A change of hormonal regulation of adenylyl cyclase in the epididymal adipose tissue of rats with experimental models of diabetes mellitus].
Diabetes Mellitus
[Attenuation of inhibitory influence of hormones on adenylyl cyclase systems in the myocardium and brain of rats with obesity and type 2 diabetes mellitus and effect of intranasal insulin on it].
Diabetes Mellitus
[BETA-ADRENERGIC REGULATION OF THE ADENYLYL CYCLASE SIGNALING SYSTEM IN MYOCARDIUM AND BRAIN OF RATS WITH OBESITY AND TYPES 2 DIABETES MELLITUS AND THE EFFECT OF LONG-TERM INTRANASAL INSULIN TREATMENT].
Diabetes Mellitus
[Effects of intranasal insulin and serotonin on functional activity of the adenylyl cyclase system in the myocardium, ovaries, and uterus of rats with prolonged neonatal model of diabetes mellitus].
Diabetes Mellitus
[Streptozocin model of diabetes mellitus in the mollusc Anodonta cygnea: functional state of the adenylyl cyclase mechanisms of action of peptides of the insulin superfamily and their effect on carbohydrate metabolism enzymes]
Diabetes Mellitus
[THE CHANGES OF NOCICEPTIVE THRESHOLD AND ACTIVITY OF THE ADENYLYL CYCLASE SYSTEM IN THE SKELETAL MUSCLES OF RATS WITH ACUTE AND MILD TYPE 1 DIABETES MELLITUS ].
Diabetes Mellitus
[The influence of long-term diabetes mellitus induced by streptozotocin treatment of six-week rats on the functional activity of adenylyl cyclase system].
Diabetes Mellitus, Experimental
Alteration of hormonal sensitivity of adenylyl cyclase in the brain of rats with prolonged streptozotocin diabetes.
Diabetes Mellitus, Experimental
Diabetes alters the responses of glucagon secreting cells and vascular bed to isoprenaline and forskolin in vitro in rat pancreas.
Diabetes Mellitus, Experimental
Diabetes reduces right atrial beta-adrenergic signaling but not agonist stimulation of heart rate in swine.
Diabetes Mellitus, Experimental
[Adenine nucleotide metabolism in the testicular tissue of alloxan diabetic rats]
Diabetes Mellitus, Experimental
[Molecular causes of changes in sensitivity of adenylyl cyclase signaling system to biogenic amines in the heart muscle during experimental streptozotocin diabetes]
Diabetes Mellitus, Type 1
Beta-adrenoceptor regulation in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Mononuclear leukocyte beta 2-adrenergic receptors and adenylate cyclase sensitivity in insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Relaxin adenylyl cyclase system of pregnant women with diabetes: functional defects in insulin and relaxin adenylyl cyclase signaling systems in myometrium of pregnant women with type 1 diabetes.
Diabetes Mellitus, Type 1
[Functional state of adenylyl cyclase signaling system in reproductive tissues of rats with experimental type 1 diabetes]
Diabetes Mellitus, Type 1
[THE CHANGES OF NOCICEPTIVE THRESHOLD AND ACTIVITY OF THE ADENYLYL CYCLASE SYSTEM IN THE SKELETAL MUSCLES OF RATS WITH ACUTE AND MILD TYPE 1 DIABETES MELLITUS ].
Diabetes Mellitus, Type 2
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus.
Diabetes Mellitus, Type 2
ADCY5 gene expression in adipose tissue is related to obesity in men and mice.
Diabetes Mellitus, Type 2
Altered action of glucagon on human liver in type 2 (non-insulin-dependent) diabetes mellitus.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Characteristic features of insulin secretion in the streptozotocin-induced NIDDM rat model.
Diabetes Mellitus, Type 2
Common genetic variants in ADCY5 and gestational glycemic traits.
Diabetes Mellitus, Type 2
Decreased glucagon-stimulated cyclic AMP production by isolated liver cells of rats with type 2 diabetes.
Diabetes Mellitus, Type 2
Development of PACAP38 Analogue with Improved Stability: Physicochemical and In Vitro/In Vivo Pharmacological Characterization.
Diabetes Mellitus, Type 2
Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes.
Diabetes Mellitus, Type 2
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Diabetes Mellitus, Type 2
G-proteins in essential hypertension: a study of human platelet plasma membranes.
Diabetes Mellitus, Type 2
Genetic variants in GCKR, GIPR, ADCY5 and VPS13C and the risk of severe sulfonylurea-induced hypoglycaemia in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Diabetes Mellitus, Type 2
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men.
Diabetes Mellitus, Type 2
Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Glucose enhances adenylyl cyclase responses in normal but not diabetic GK rat islets.
Diabetes Mellitus, Type 2
Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis.
Diabetes Mellitus, Type 2
Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat.
Diabetes Mellitus, Type 2
Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study.
Diabetes Mellitus, Type 2
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Diabetes Mellitus, Type 2
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Diabetes Mellitus, Type 2
Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes.
Diabetes Mellitus, Type 2
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Diabetes Mellitus, Type 2
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Diabetes Mellitus, Type 2
Nitric oxide generation mediated by beta-adrenoceptors is impaired in platelets from patients with Type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes.
Diabetes Mellitus, Type 2
Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals.
Diabetes Mellitus, Type 2
The influence of bromocryptine treatment on activity of the adenylyl cyclase system in the brain of rats with type 2 diabetes mellitus induced by high-fat diet.
Diabetes Mellitus, Type 2
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
Diabetes Mellitus, Type 2
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Diabetes Mellitus, Type 2
[A decrease of sensitivity of adenylyl cyclase and heterotrimeric G-proteins to chorionic gonadotropin and peptide hormones action in the tissues of reproductive system of the rats in the condition of experimental type 2 diabetes].
Diabetes Mellitus, Type 2
[Adenylyl cyclase signaling mechanisms of the insulin superfamily peptide action and their impairment in myometrium of pregnant women with type 2 diabetes]
Diabetes Mellitus, Type 2
[Attenuation of inhibitory influence of hormones on adenylyl cyclase systems in the myocardium and brain of rats with obesity and type 2 diabetes mellitus and effect of intranasal insulin on it].
Diabetes Mellitus, Type 2
[BETA-ADRENERGIC REGULATION OF THE ADENYLYL CYCLASE SIGNALING SYSTEM IN MYOCARDIUM AND BRAIN OF RATS WITH OBESITY AND TYPES 2 DIABETES MELLITUS AND THE EFFECT OF LONG-TERM INTRANASAL INSULIN TREATMENT].
Diabetes Mellitus, Type 2
[Study of hormone responsiveness of the adenylyl cyclase signaling system in erythrocyte membranes of patients with type 2 diabetes mellitus].
Diabetes Mellitus, Type 2
[The influence of two-month treatment with bromocryptine on activity of the adenylyl cyclase signaling system in the myocardium and testes of rats with type 2 diabetes mellitus].
Diabetes, Gestational
ADCY5, CAPN10 and JAZF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes.
Diabetic Angiopathies
Platelet aggregation, platelet cAMP levels and thromboxane B2 synthesis in patients with diabetes mellitus.
Diabetic Cardiomyopathies
Adrenergic desensitization in left ventricle from streptozotocin diabetic swine.
Diabetic Cardiomyopathies
Alterations in adenylate cyclase activity due to streptozotocin-induced diabetic cardiomyopathy.
Diabetic Cardiomyopathies
beta-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in the diabetic rat.
Diabetic Cardiomyopathies
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology.
Diabetic Cardiomyopathies
Selective alteration of secretin-stimulated cardiac adenylate cyclase activity in streptozotocin-diabetic rats.
Diabetic Nephropathies
Role of adenylyl cyclase activator in controlling experimental diabetic nephropathy in rats.
Diabetic Neuropathies
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Diabetic Retinopathy
Effects of PACAP on Intracellular Signaling Pathways in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress.
Diabetic Retinopathy
PACAP Application Improves Functional Outcome of Chronic Retinal Ischemic Injury in Rats-Evidence From Electroretinographic Measurements.
Diabetic Retinopathy
PACAP promotes neuron survival in early experimental diabetic retinopathy.
Diabetic Retinopathy
Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway.
Diphtheria
A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol.
Diphtheria
Conditional ablation of mature olfactory sensory neurons mediated by diphtheria toxin receptor.
Diphtheria
Diphtheria toxin prevents catecholamine desensitization of A431 human epidermoid carcinoma cells.
Diphtheria
Hydrolysis of nicotinamide adenine dinucleotide by choleragen and its A protomer: possible role in the activation of adenylate cyclase.
Diphtheria
IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells.
Diphtheria
Mechanism of Diphtheria Toxin Catalytic Domain Delivery to the Eukaryotic Cell Cytosol and the Cellular Factors that Directly Participate in the Process.
Diverticulitis
Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms.
Donohue Syndrome
Decreased cyclic guanosine 3',5' monophosphate and guanylate cyclase activity in leprechaunism: evidence for a postreceptor defect.
Ductus Arteriosus, Patent
Role of cyclic nucleotides in relaxation of fetal lamb ductus arteriosus.
Duodenal Ulcer
[Adenyl cyclase activity of gastric mucosa in patients with duodenal ulcer before and after treatment]
Duodenal Ulcer
[Adenylate cyclase activity of the gastric mucosa and the morphological changes in the gastrointestinal tract in the experimental reproduction of duodenal ulcers with subsequent truncal vagotomy]
Dwarfism, Pituitary
Decreased epinephrine response of adenylate cyclase activity of lymphoid cells from immunodeficient pituitary dwarf mice.
Dysentery, Bacillary
Increased colonic adenylate cyclase activity in active ulcerative colitis.
Dysentery, Bacillary
[Prostaglandins and cyclic nucleotides in the gastrointestinal form of yersiniosis]
Dyskinesias
ADCY5 mutation carriers display pleiotropic paroxysmal day and nighttime dyskinesias.
Dyskinesias
ADCY5-related dyskinesia: Broader spectrum and genotype-phenotype correlations.
Dyskinesias
An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
Dyskinesias
Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.
Dyskinesias
Depression and psychosis in ADCY5-related dyskinesia-part of the phenotypic spectrum?
Dyskinesias
Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats.
Dyskinesias
Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia.
Dyskinesias
Hyperphosphorylated Tau, Increased Adenylate Cyclase 5 (ADCY5) Immunoreactivity, but No Neuronal Loss in ADCY5-Dyskinesia.
Dyskinesias
Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease.
Dyskinesias
l-DOPA-induced dyskinesia in hemiparkinsonian rats is associated with up-regulation of adenylyl cyclase type V/VI and increased GABA release in the substantia nigra reticulata.
Dyskinesias
Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease.
Dyskinesias
Teaching Video NeuroImage: Paroxysmal Nocturnal Dyskinesias: A Characteristic Feature of ADCY5 Mutation.
Dyskinesias
[ADCY5-associated dyskinesia in young children: a case report of a family and an updated review].
Dyskinesias
[Familial dyskinesia and facial myokymia in a patient with ADCY5 gene mutation].
Dystonia
4-phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.
Dystonia
A de novo ADCY5 mutation causes early-onset autosomal dominant chorea and dystonia.
Dystonia
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Embolism
Impairment of adenylyl cyclase and of spatial memory function after microsphere embolism in rats.
Embolism
Selective reduction in type I adenylyl cyclase after microsphere embolism in rat brain.
Endolymphatic Hydrops
Adenylate cyclase modulation of ion permeability in the guinea pig cochlea: a possible mechanism for the formation of endolymphatic hydrops.
Endolymphatic Hydrops
Signs of endolymphatic hydrops after perilymphatic perfusion of the guinea pig cochlea with cholera toxin; a pharmacological model of acute endolymphatic hydrops.
Endometrial Neoplasms
Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines.
Endometriosis
Human chorionic gonadotropin induces decidualization of ectopic human endometrium more effectively than forskolin in an in-vivo endometriosis model.
Endotoxemia
Endotoxin-exposed atria exhibit G protein-based deficits in inotropic regulation.
Endotoxemia
Lipopolysaccharide attenuates mRNA levels of several adenylyl cyclase isoforms in vivo.
Endotoxemia
Uncoupling of coronary microvascular beta 2-adrenoceptors by Escherichia coli endotoxemia.
Enterocolitis, Pseudomembranous
Purified Clostridium difficile cytotoxin stimulates guanylate cyclase activity and inhibits adenylate cyclase activity.
Epilepsy
Anticonvulsant effect of cytoskeletal depolymerizers in combination with potassium channel opener and adenylate cyclase activator; a causative link with nerve growth factor?
Epilepsy
Effects of Huazhuo Jiedu Shugan Decoction on Cognitive and Emotional Disorders in a Rat Model of Epilepsy: Possible Involvement of AC-cAMP-CREB Signaling and NPY Expression.
Epilepsy
Lateral difference in responsiveness of norepinephrine-sensitive cyclic AMP-generating systems of rat cerebral cortex with iron-induced epileptic activity.
Epilepsy
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
Epilepsy
Up-regulation of type II adenylyl cyclase mRNA in kindling model of epilepsy in rats.
Epilepsy, Temporal Lobe
Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.
Epstein-Barr Virus Infections
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase.
Erectile Dysfunction
Pathogen-host jujitsu: phagocyte impotence caused by internalized bacterial adenylate cyclase.
Erectile Dysfunction
Stimulation of femoral trabecular bone growth in ovariectomized rats by human parathyroid hormone (hPTH)-(1-30)NH(2).
Erythema
Prevention of cerebral vasospasm by vasodilatory peptide maxadilan following subarachnoid hemorrhage in rabbits.
Erythema
Ultraviolet radiation augments epidermal beta-adrenergic adenylate cyclase response.
Essential Hypertension
Adrenoceptors, calcium, and vasoconstriction in normal and hypertensive humans.
Essential Hypertension
Increased forskolin stimulation of lymphocyte-adenylate cyclase in normotensive subjects predisposed to essential hypertension.
Essential Hypertension
[Association between single nucleotide polymorphism of adenylyl cyclase 3 and essential hypertension].
Essential Hypertension
[Effect of Visken therapy on the lymphocyte beta2-adrenoceptor-dependent adenylate cyclase system in essential hypertension]
Euthyroid Sick Syndromes
Stimulation of thyroid adenylate cyclase activity by sera from patients with non-thyroidal illness.
Exanthema
Adenylate cyclase activity of NIH 3T3 cells morphologically transformed by ras genes.
Exophthalmos
Structure of an exophthalmos-producing factor derived from thyrotropin by partial pepsin digestion.
Facial Nerve Diseases
Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.
Facial Nerve Diseases
Facial twitches in ADCY5-associated disease - Myokymia or myoclonus? An electromyography study.
Facial Nerve Diseases
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
Facial Nerve Diseases
[Familial dyskinesia and facial myokymia in a patient with ADCY5 gene mutation].
Familial Hypophosphatemic Rickets
In vivo Response of X-linked hypophosphatemic mice to calcitonin.
Familial Primary Pulmonary Hypertension
The cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in monocrotaline-treated rats.
Fanconi Syndrome
Renal refractoriness to PTH in experimental Fanconi syndrome: evidence for intact adenylate cyclase activation.
Fetal Alcohol Spectrum Disorders
Dysregulation of TrkB phosphorylation and proBDNF protein in adenylyl cyclase 1 and 8 knockout mice in a model of fetal alcohol spectrum disorder.
Fetal Growth Retardation
Polymorphic variants of bovine ADCY5 gene identified in GWAS analysis were significantly associated with ovarian morphological related traits.
Fibrous Dysplasia of Bone
Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression.
Fibrous Dysplasia, Monostotic
Increased proliferation of osteoblastic cells expressing the activating Gs alpha mutation in monostotic and polyostotic fibrous dysplasia.
Fibrous Dysplasia, Polyostotic
Clinical implications of genetic defects in G proteins: oncogenic mutations in G alpha s as the molecular basis for the McCune-Albright syndrome.
Fibrous Dysplasia, Polyostotic
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.
Fibrous Dysplasia, Polyostotic
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Fibrous Dysplasia, Polyostotic
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia.
Fibrous Dysplasia, Polyostotic
The new bone biology: pathologic, molecular, and clinical correlates.
Fibrous Dysplasia, Polyostotic
Urinary cyclic adenosine 3',5'-monophosphate response in McCune-Albright syndrome: clinical evidence for altered renal adenylate cyclase activity.
Ganglion Cysts
Sensitivity of Adenylyl Cyclase Signaling System of the Mollusk Anodonta cygnea Ganglions to Serotonin and Adrenergic Agonists.
Ganglioneuroblastoma
Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in ganglioneuroblastoma and neuroblastoma.
Gangliosidoses, GM2
Altered phosphoinositide-specific phospholipase C and adenylyl cyclase in brain cortical membranes of cats with GM1 and GM2 gangliosidosis.
Gastrinoma
Characterization of the in vivo and in vitro inhibition of gastrin secretion from gastrinoma by a somatostatin analogue (SMS 201-995).
Gastrinoma
Failure of secretin to stimulate gastrin release and adenylate cyclase activity in gastrinoma in vitro.
Gastrinoma
Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome.
Gastroenteritis
Jejunal adenylate cyclase activity in human subjects during viral gastroenteritis.
Genetic Diseases, Inborn
An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
Genetic Diseases, Inborn
Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification.
Genetic Diseases, Inborn
The new bone biology: pathologic, molecular, and clinical correlates.
Glioblastoma
Antidepressant-induced switch of beta 1-adrenoceptor trafficking as a mechanism for drug action.
Glioblastoma
Somatostatin and somatostatin receptors in the diagnosis and treatment of gliomas.
Glioblastoma
VIP and pituitary adenylate cyclase activating polypeptide (PACAP) have an antiproliferative effect on the T98G human glioblastoma cell line through interaction with VIP2 receptor.
Glioma
2-Alkylthio-substituted platelet P2Y12 receptor antagonists reveal pharmacological identity between the rat brain Gi-linked ADP receptors and P2Y12.
Glioma
A hormone-independent rise of adenosine 3',5'-monophosphate desensitizes coupling of beta-adrenergic receptors to adenylate cyclase in rat glioma C6-cells.
Glioma
A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils.
Glioma
Activation of adenylate cyclase results in down-regulation of c-jun mRNA expression in rat C6 glioma cells.
Glioma
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Glioma
Adenovirus-mediated expression of an olfactory cyclic nucleotide-gated channel regulates the endogenous Ca2+-inhibitable adenylyl cyclase in C6-2B glioma cells.
Glioma
Adenylyl cyclase supersensitivity in opioid-withdrawn NG108-15 hybrid cells requires Gs but is not mediated by the Gsalpha subunit.
Glioma
ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.
Glioma
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.
Glioma
ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).
Glioma
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.
Glioma
Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity.
Glioma
Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor.
Glioma
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Glioma
Alpha 2-adrenergic receptors in neuroblastoma x glioma hybrid cells. Characterization with agonist and antagonist radioligands and relationship to adenylate cyclase.
Glioma
Attenuation of enkephalin activity in neuroblastoma X glioma NG108-15 hybrid cells by phospholipases.
Glioma
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Glioma
Beta adrenergic receptor repopulation of C6 glioma cells after irreversible blockade and down regulation.
Glioma
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Glioma
Capacitative Ca2+ entry exclusively inhibits cAMP synthesis in C6-2B glioma cells. Evidence that physiologically evoked Ca2+ entry regulates Ca(2+)-inhibitable adenylyl cyclase in non-excitable cells.
Glioma
Catecholamine-induced desensitization of adenylate cyclase in rat glioma C6 cells. Evidence for a specific uncoupling of beta-adrenergic receptors from a functional regulatory component of adenylate cyclase.
Glioma
Cell-free desensitization of opioid inhibition of adenylate cyclase in neuroblastoma X glioma NG108-15 hybrid cell membranes.
Glioma
Characterization of agonist-induced beta-adrenergic receptor-specific desensitization in C62B glioma cells.
Glioma
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Glioma
Cholera toxin mediated regulation of the expression of Gq alpha and G11 alpha GTP binding proteins.
Glioma
Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number.
Glioma
Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase.
Glioma
Comparison of opiate inhibition of adenylate cyclase activity in neuroblastoma N18tG2 and neuroblastoma x glioma NG108-15 hybrid cell lines.
Glioma
Concanavalin A prevents phorbol-mediated redistribution of protein kinase C and beta-adrenergic receptors in rat glioma C6 cells.
Glioma
Control of opiate receptor-adenylate cyclase interactions by calcium ions and guanosine-5'-triphosphate.
Glioma
Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion.
Glioma
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
Glioma
delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells.
Glioma
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Glioma
Dependence of the Ca2+-inhibitable adenylyl cyclase of C6-2B glioma cells on capacitative Ca2+ entry.
Glioma
Desensitization of catecholamine-stimulated adenylate cyclase and down-regulation of beta-adrenergic receptors in rat glioma C6 cells. Role of cyclic AMP and protein synthesis.
Glioma
Desensitization of the beta-adrenergic receptor-coupled adenylate cyclase in cultured mammalian cells. Receptor sequestration versus receptor function.
Glioma
Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and beta 2-adrenoceptor-expressing NG108-15 cells.
Glioma
Differential effects of P2-purinoceptor antagonists on phospholipase C- and adenylyl cyclase-coupled P2Y-purinoceptors.
Glioma
Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells.
Glioma
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.
Glioma
Docosahexaenoic acid alters Gs? localization in lipid raft and potentiates adenylate cyclase.
Glioma
Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cells.
Glioma
Down-regulation of protein kinase C in rat glioma C6 cells: effects on the beta-adrenergic receptor-coupled adenylate cyclase.
Glioma
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Glioma
Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells.
Glioma
Effect of phospholipases on chronic opiate action in neuroblastoma X glioma NG108-15 hybrid cells.
Glioma
Effects of protein kinase A activation on endothelin- and ATP-induced signal transduction.
Glioma
Effects of valproic acid on beta-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells.
Glioma
Efficacy of inverse agonists in cells overexpressing a constitutively active beta2-adrenoceptor and type II adenylyl cyclase.
Glioma
Endogenous regulator of G protein signaling proteins suppress Galphao-dependent, mu-opioid agonist-mediated adenylyl cyclase supersensitization.
Glioma
Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium.
Glioma
Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization.
Glioma
Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells.
Glioma
Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells.
Glioma
Exfoliation of the beta-adrenergic receptor and the regulatory components of adenylate cyclase by cultured rat glioma C6 cells.
Glioma
Expression of pituitary adenylate cyclase activating polypeptide (PACAP) receptors in human glial cell tumors.
Glioma
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
Glioma
G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells.
Glioma
G?(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.
Glioma
Generation of cell surface neoganglioproteins. GM1-neoganglioproteins are non-functional receptors for cholera toxin.
Glioma
Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3':5'-monophosphate.
Glioma
Gs alpha-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells.
Glioma
Guanine nucleotide activation of adenylate cyclase in saponin permeabilized glioma cells.
Glioma
Guanine nucleotide-independent inhibition of adenylate cyclase by a stimulatory hormone.
Glioma
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Glioma
Guanosine-5'-O-thiodiphosphate functions as a partial agonist for the receptor-independent stimulation of neural adenylate cyclase.
Glioma
Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency.
Glioma
Inhibition by lithium of PGE1-sensitive adenylate cyclase in neuroblastoma X glioma hybrid cells: approach to the attenuation of the opiate withdrawal syndrome.
Glioma
Inhibition by methylmercuric chloride of prostaglandin E1-sensitive adenylate cyclase activity in glioma but not in neuroblastoma cells in culture.
Glioma
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells.
Glioma
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Glioma
Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA.
Glioma
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Glioma
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Glioma
Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.
Glioma
Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins.
Glioma
Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells.
Glioma
Irreversible blockade of beta-adrenergic receptors with a bromoacetyl derivative of pindolol.
Glioma
Lipid requirement for long-lived morphine-dependent activations of adenylate cyclase of neuroblastoma X glioma hybrid cells.
Glioma
Mechanisms of downregulation of beta-adrenergic receptors: perspective on the role of beta-adrenergic receptors in congestive heart failure.
Glioma
Modification of neuroblastoma x glioma hybrid NG108-15 adenylate cyclase by vanadium ions.
Glioma
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.
Glioma
Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
Glioma
Modulation of adenylate cyclase activity by a cytosolic factor following chronic opiate exposure in neuroblastoma x glioma NG108-15 hybrid cells.
Glioma
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Glioma
Mu and delta opiate receptors coupled negatively to adenylate cyclase on embryonic neurons from the mouse striatum in primary cultures.
Glioma
Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation.
Glioma
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Glioma
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
Glioma
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Glioma
Neuroblastoma X glioma NG108-15 hybrid cells cultured in a serum-free chemically defined medium: effects on acute and chronic opiate regulation of adenylate cyclase activity.
Glioma
Ni-coupled receptors in cultured neural hybrid cells: cell specificity for dibutyryl cyclic AMP-induced down-regulation but not morphological differentiation.
Glioma
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Glioma
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.
Glioma
Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells.
Glioma
Pharmacological and second messenger signalling selectivities of cloned P2Y receptors.
Glioma
Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms.
Glioma
Photolabile opioid derivatives of D-Ala2-Leu5-enkephalin and their interactions with the opiate receptor.
Glioma
Potent Gi-mediated inhibition of adenylyl cyclase by a phosphonate analog of monooleylphosphatidate.
Glioma
Pre-steady state study of beta-adrenergic and purinergic receptor interaction in C6 cell membranes: undelayed balance between positive and negative coupling to adenylyl cyclase.
Glioma
Predominant expression of type-VI adenylate cyclase in C6-2B rat glioma cells may account for inhibition of cyclic AMP accumulation by calcium.
Glioma
Presence of calcitonin gene-related peptide receptors coupled to adenylate cyclase in human gliomas.
Glioma
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Glioma
Protein tyrosine kinase-dependent regulation of adenylate cyclase and phosphatidylinositol 3-kinase activates the expression of glial fibrillary acidic protein upon induction of differentiation in rat c6 glioma.
Glioma
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
Glioma
Receptor-associated changes of the catecholamine-sensitive adenylate cyclase in glioma cells doubly transformed with Moloney sarcoma virus.
Glioma
Regulation of adenylate cyclase from glial tumor cells by calcium and a calcium-binding protein.
Glioma
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.
Glioma
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. II. Long lived increase of adenylate cyclase activity mediated by alpha receptors.
Glioma
Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade.
Glioma
Regulation of stimulatory adenylyl cyclase signaling during forskolin-induced differentiation of mouse neuroblastoma x rat glioma (NG108-15) cells.
Glioma
Regulation of the Ca2+-inhibitable adenylyl cyclase type VI by capacitative Ca2+ entry requires localization in cholesterol-rich domains.
Glioma
Relationship between desensitization and sequestration of muscarinic cholinergic receptors in two neuronal cell lines.
Glioma
Residence of adenylyl cyclase type 8 in caveolae is necessary but not sufficient for regulation by capacitative Ca(2+) entry.
Glioma
Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas.
Glioma
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor.
Glioma
Specificity of interactions of receptors and effectors with GTP-binding proteins in native membranes.
Glioma
Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors?
Glioma
The 5HT5A serotonin receptor is expressed predominantly by astrocytes in which it inhibits cAMP accumulation: a mechanism for neuronal suppression of reactive astrocytes.
Glioma
The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein.
Glioma
The beta-adrenergic receptor system in human glioma-derived cell lines: the mode of phosphodiesterase induction and the macromolecules phosphorylated by cyclic AMP-dependent protein kinase.
Glioma
The beta-adrenoceptor-coupled adenylate cyclase system in rat C6 glioma cells. Deamplification by isoproterenol and oxaprotiline.
Glioma
The C6-2B glioma cell P2Y(AC) receptor is pharmacologically and molecularly identical to the platelet P2Y(12) receptor.
Glioma
The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients.
Glioma
The effects of exposure to unsaturated fatty acids on opiate receptors, prostaglandin E1 receptors, and adenylate cyclase activity of neuroblastoma x glioma hybrid cells.
Glioma
The P2Y purinoceptor in rat brain microvascular endothelial cells couple to inhibition of adenylate cyclase.
Glioma
The role and specificity of guanine nucleotide binding proteins in receptor-effector coupling.
Glioma
Transfer of functional opiate receptors from membranes to recipient cells by polyethylene glycol-induced fusion.
Glioma
Treatment of C6 glioma cells and rats with antidepressant drugs increases the detergent extraction of G(s alpha) from plasma membrane.
Glioma
Tubulin stimulates adenylyl cyclase activity in C6 glioma cells by bypassing the beta-adrenergic receptor: a potential mechanism of G protein activation.
Glioma
Turn on and turn off reactions of beta-adrenergic-sensitive adenylate cyclase in control and desensitized C6 glioma cells.
Glioma
Up-regulation of a constitutively active form of the beta2-adrenoceptor by sustained treatment with inverse agonists but not antagonists.
Glioma
Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas.
Glioma
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
Glucose Intolerance
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Goiter
Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas.
Goiter
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Goiter
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells.
Goiter
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Goiter
Influence of thyroglobulin on basal and stimulated human thyroid adenylate cyclase activity.
Goiter
Localization of adenylate cyclase and 5'-nucleotidase activities in human thyroid follicular cells.
Goiter
Serum thyroid-stimulating antibody, thyroglobulin levels, and thyroid suppressibility measurement as predictors of the outcome of combined methimazole and triiodothyronine therapy in Graves' disease.
Goiter
Subgroups of Graves' patients identified on the basis of the biochemical activities of their immunoglobulins.
Goiter
Thyrotropin receptor-adenylate cyclase system in plasma membranes from normal and diseased human thyroid glands.
Goiter
[Transgenic models of human thyroid pathologies: hyperfunctional adenoma, anaplastic cancer, differentiated cancer, hypothyroidism]
Goiter, Endemic
Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter.
Goiter, Endemic
Use of FRTL-5 for the study of thyroid antibodies involved in goitrogenesis.
Goiter, Nodular
Thyrotropin receptor-adenylate cyclase system in plasma membranes from normal and diseased human thyroid glands.
Gout
P2Y14 receptor has a critical role in acute gouty arthritis by regulating pyroptosis of macrophages.
Granuloma
Alteration of granuloma formation by PGE1: effects of an adenylate cyclase inhibitor and splenectomy.
Granuloma
Granulomas in murine schistosomiasis mansoni contain vasoactive intestinal peptide-responsive lymphocytes.
Granuloma
Macrophages as targets of inhibitory effects of E-type prostaglandins in immune-related inflammation.
Graves Disease
A sensitive method for assaying thyroid stimulating immunoglobulins of Graves' disease: use of the guanyl nucleotide-amplified thyroid adenylate cyclase assay.
Graves Disease
Abnormal adenylate cyclase activity and altered membrane gangliosides in thyroid cells from patients with Graves' disease.
Graves Disease
Adenylate cyclase activity in thyroid tissue from patients with untreated Graves' disease.
Graves Disease
Cyclooxygenase-dependent thyroid cell proliferation induced by immunoglobulins from patients with Graves' disease.
Graves Disease
Detection of thyroid-stimulating antibody using Chinese hamster ovary cells transfected with cloned human thyrotropin receptor.
Graves Disease
Detection of tsh binding inhibiting antibodies (TBI-ab) and thyroid adenylate cyclase stimulating antibodies (TS-ab) in sera of patients with Graves' disease.
Graves Disease
Differences between changes in serum thyrotropin-binding inhibitory antibodies and thyroid-stimulating antibodies in the course of antithyroid drug therapy for Graves' disease.
Graves Disease
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Graves Disease
Evidence for normal thyroidal adenyl cyclase, cyclic AMP-binding and protein-kinase activities in Graves' disease.
Graves Disease
Evidence of a correlation between thyrotrophin receptor binding inhibition and thyroid adenylate cyclase activation by immunoglobulins in Graves' disease before and during long-term antithyroid treatment.
Graves Disease
Evidence supporting the identity in Graves' disease of thyroid-stimulating antibody and thyroid growth-promoting immunoglobulin G as assayed in FRTL5 cells.
Graves Disease
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells.
Graves Disease
Human thyroid adenyl cyclase-stimulating activity in immunoglobulin G of patients with Graves' disease.
Graves Disease
In vitro lymphocyte proliferation in response to polyclonal activators and microbial antigens, and production of immunoglobulins stimulating thyroid adenylate cyclase in Graves' disease.
Graves Disease
Influences of cholera toxin on thyroid stimulation by thyrotropin and thyroid-stimulating antibody.
Graves Disease
Inhibition of adenylate cyclase activity of human thyroid membranes by gangliosides.
Graves Disease
Interactions between TSH binding inhibiting--and adenylate cyclase stimulating--antibodies in Graves' disease.
Graves Disease
Micromethod of human thyrocyte cultures for detection of thyroid-stimulating antibodies and thyrotrophin.
Graves Disease
Serum thyroid-stimulating antibody, thyroglobulin levels, and thyroid suppressibility measurement as predictors of the outcome of combined methimazole and triiodothyronine therapy in Graves' disease.
Graves Disease
The prognostic value of parallel measurements of thyrotropin binding inhibiting immunoglobulins (TBII) and thyroid adenylate cyclase stimulating antibodies (TSAb) in Graves' disease after longterm antithyroid treatment.
Graves Disease
The use of the amplifiable high-expression vector pEE14 to study the interactions of autoantibodies with recombinant human thyrotrophin receptor.
Graves Disease
TSH and thyroid stimulating antibodies (TSAb) activate thyroid adenylate cyclase through different pathways.
Graves Disease
TSH-responsive adenylate cyclase activity in thyroid tissue from patients with Graves' disease.
Graves Disease
Unlike thyrotropin, thyroid-stimulating antibodies do not activate phospholipase C in human thyroid slices.
Graves Disease
[A comparison of various indicators of murine thyroid stimulation by LATS (author's transl)]
Graves Disease
[Proceedings: Thyroid stimulating substances in man. (1). New findings concerning autoregulation of the thyroid gland of man: increases of adenyl cyclase caused by TSH administration and their inhibition by T3 and T4 in the thyroid of normal individuals and patients with Basedow's disease]
Growth Hormone-Secreting Pituitary Adenoma
Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas.
Growth Hormone-Secreting Pituitary Adenoma
Characterization of the intracellular mechanisms mediating somatostatin and lanreotide inhibition of DNA synthesis and growth hormone release from dispersed human GH-secreting pituitary adenoma cells in vitro.
Growth Hormone-Secreting Pituitary Adenoma
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.
Growth Hormone-Secreting Pituitary Adenoma
Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas.
Growth Hormone-Secreting Pituitary Adenoma
Mutations in the alpha subunit of the stimulatory regulatory protein of adenylyl cyclase (Gs) in human GH-secreting pituitary adenomas. Biochemical, clinical, and morphological aspects.
Growth Hormone-Secreting Pituitary Adenoma
Presence of an adenylate cyclase dually regulated by somatostatin and human pancreatic growth hormone (GH)-releasing factor in GH-secreting cells.
Hashimoto Disease
Epidermal growth factor receptors and adenylate cyclase activity in human thyroid tissues.
Hearing Loss
Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish.
Hearing Loss
Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice.
Heart Arrest
The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse.
Heart Arrest
The effect of cardiac arrest on the permeability of the mouse blood-brain and blood-spinal cord barrier to pituitary adenylate cyclase activating polypeptide (PACAP).
Heart Arrest
Uncoupling of human cardiac beta-adrenoceptors during cardiopulmonary bypass with cardioplegic cardiac arrest.
Heart Defects, Congenital
A post-receptor defect of adenylyl cyclase in severely failing myocardium from children with congenital heart disease.
Heart Defects, Congenital
Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.
Heart Defects, Congenital
Differences in response to activation of adenylyl cyclase by various stimulants in human myocardium.
Heart Defects, Congenital
Distribution of myocardial beta-adrenoceptor subtypes and coupling to the adenylate cyclase in children with congenital heart disease and implications for treatment.
Heart Defects, Congenital
Uncoupling of human cardiac beta-adrenoceptors during cardiopulmonary bypass with cardioplegic cardiac arrest.
Heart Diseases
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Heart Diseases
New aspects for the treatment of cardiac diseases based on the diversity of functional controls on cardiac muscles: effects of targeted disruption of the type 5 adenylyl cyclase gene.
Heart Diseases
Post receptor determinants of acute platelet response to clopidogrel in patients with symptomatic myocardial ischemia.
Heart Diseases
Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP.
Heart Failure
A Computational Approach for Understanding the Interactions between Graphene Oxide and Nucleoside Diphosphate Kinase with Implications for Heart Failure.
Heart Failure
A kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology.
Heart Failure
A mechanism of catecholamine tolerance in congestive heart failure--alterations in the hormone sensitive adenylyl cyclase system of the heart.
Heart Failure
A post-receptor defect of adenylyl cyclase in severely failing myocardium from children with congenital heart disease.
Heart Failure
AAV-mediated gene therapy for heart failure: enhancing contractility and calcium handling.
Heart Failure
Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice.
Heart Failure
Activity of receptors coupled to guanine nucleotide binding regulatory protein in doxorubicin induced cardiomyopathy.
Heart Failure
Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction.
Heart Failure
Adenylyl cyclase and G protein receptor kinase expression during development of heart failure.
Heart Failure
Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats.
Heart Failure
Age-dependent changes in the beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in human right atrium.
Heart Failure
Alterations in cardiac beta-adrenoceptor responsiveness and adenylate cyclase system by congestive heart failure in dogs.
Heart Failure
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Heart Failure
Alterations of adenylyl cyclase and G proteins in aortocaval shunt-induced heart failure.
Heart Failure
Alterations of beta-adrenoceptor-G-protein-regulated adenylyl cyclase in heart failure.
Heart Failure
Attenuation of changes in G(i)-proteins and adenylyl cyclase in heart failure by an ACE inhibitor, imidapril.
Heart Failure
Augmentation of cardiac contractility with no change in L-type Ca2+ current in transgenic mice with a cardiac-directed expression of the human adenylyl cyclase type 8 (AC8).
Heart Failure
Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium.
Heart Failure
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Heart Failure
Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
Heart Failure
Beta-adrenergic signal transduction in the failing and hypertrophied myocardium.
Heart Failure
Beta-adrenoceptor and adenylate cyclase function in the infarct model of rat heart failure.
Heart Failure
Beta-adrenoceptor mediated signal transduction in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Heart Failure
Beta-adrenoceptors and adenylate cyclase activity in hypertrophied and failing rabbit left ventricle.
Heart Failure
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Heart Failure
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Heart Failure
Catecholamine refractoriness and their mechanisms in cardiocirculatory shock and chronic heart failure.
Heart Failure
Changes in cardiac signal transduction systems in chronic ethanol treatment preceding the development of alcoholic cardiomyopathy.
Heart Failure
Changes in the receptor-G protein-adenylyl cyclase system in heart failure from various types of heart muscle disease.
Heart Failure
Characterization of lymphocyte beta-adrenergic receptors at rest and during exercise in ambulatory patients with chronic congestive heart failure.
Heart Failure
Clopidogrel improves endothelial function and NO bioavailability by sensitizing adenylyl cyclase in rats with congestive heart failure.
Heart Failure
Comparison of heart sarcolemmal enzyme activities in normal and cardiomyopathic (UM-X7.1) hamsters.
Heart Failure
Coupling of ?1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes.
Heart Failure
Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts.
Heart Failure
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
Heart Failure
Decreased type VI adenylyl cyclase mRNA concentration and Mg(2+)-dependent adenylyl cyclase activities and unchanged type V adenylyl cyclase mRNA concentration and Mn(2+)-dependent adenylyl cyclase activities in the left ventricle of rats with myocardial infarction and longstanding heart failure.
Heart Failure
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Heart Failure
Desensitization of the pulmonary adenylyl cyclase system: a cause of airway hyperresponsiveness in congestive heart failure?
Heart Failure
Design of a Phase 3 trial of intracoronary administration of human adenovirus 5 encoding human adenylyl cyclase type 6 (RT-100) gene transfer in patients with heart failure with reduced left ventricular ejection fraction: The FLOURISH Clinical Trial.
Heart Failure
Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failure.
Heart Failure
Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction.
Heart Failure
Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.
Heart Failure
Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs.
Heart Failure
Downregulation of cardiac guanosine 5'-triphosphate-binding proteins in right atrium and left ventricle in pacing-induced congestive heart failure.
Heart Failure
Drug therapy aimed at adenylyl cyclase to regulate cyclic nucleotide signaling.
Heart Failure
Effects of beta-blockade on beta-adrenergic receptors and signal transduction.
Heart Failure
Effects of chronic heart failure on the capacity of glucagon to enhance contractility and adenyl cyclase activity of human papillary muscles.
Heart Failure
Effects of experimental heart failure on the capacity of glucagon to augment myocardial contractility and activate adenyl cyclase.
Heart Failure
Expression of a beta-adrenergic receptor kinase inhibitor reverses dysfunction in failing cardiomyocytes.
Heart Failure
Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure.
Heart Failure
Homologous vs. heterologous desensitization of the adenylate cyclase system in heart cells.
Heart Failure
Hypersensitivity of Gi protein mediated muscarinic receptor adenylyl cyclase in chronic ischaemic heart failure in the rat.
Heart Failure
Improvement of cholera toxin-catalyzed ADP-ribosylation by endogenous ADP-ribosylation factor from bovine brain provides evidence for an unchanged amount of Gs alpha in failing human myocardium.
Heart Failure
Increased myocardial muscarinic receptor density in idiopathic dilated cardiomyopathy: an in vivo PET study.
Heart Failure
Inhibition of endogenous nitric oxide synthase augments contractile response to adenylyl cyclase stimulation without altering mechanical efficiency in patients with idiopathic dilated cardiomyopathy.
Heart Failure
Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.
Heart Failure
Interactions between phospholamban and beta-adrenergic drive may lead to cardiomyopathy and early mortality.
Heart Failure
Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure.
Heart Failure
Intracoronary Gene Transfer of Adenylyl Cyclase 6 in Patients With Heart Failure: A Randomized Clinical Trial.
Heart Failure
Intraventricular changes in the beta-adrenoceptor-adenylate cyclase system of the rat heart with the progress of monocrotaline-induced right ventricular hypertrophy.
Heart Failure
L-type calcium currents of human myocytes from ventricle of non-failing and failing hearts and from atrium.
Heart Failure
Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure.
Heart Failure
Measurement of adenylate cyclase activity in the right ventricular endomyocardial biopsy samples from patients with chronic congestive heart failure.
Heart Failure
Mechanisms of downregulation of beta-adrenergic receptors: perspective on the role of beta-adrenergic receptors in congestive heart failure.
Heart Failure
Methods for the detection of altered beta-adrenergic receptor signaling pathways in hypertrophied hearts.
Heart Failure
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
Heart Failure
Molecular mechanism of contractile dysfunction in cardiac allograft rejection.
Heart Failure
Myocardial beta-adrenergic receptor function during the development of pacing-induced heart failure.
Heart Failure
Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice.
Heart Failure
Myocardial dysfunction following cardiopulmonary bypass: recovery patterns, predictors of inotropic need, theoretical concepts of inotropic administration.
Heart Failure
Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease.
Heart Failure
New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy.
Heart Failure
Noradrenaline-induced desensitization in cultured heart cells as a model for the defects of the adenylate cyclase system in severe heart failure.
Heart Failure
Physiological and biochemical evidence for coordinate increases in muscarinic receptors and Gi during pacing-induced heart failure.
Heart Failure
Positive inotropic stimulation in the normal and insufficient human myocardium.
Heart Failure
Prevention of heart failure in mice by an antiviral agent that inhibits type 5 cardiac adenylyl cyclase.
Heart Failure
Quantification of Gi alpha-proteins in the failing and nonfailing human myocardium.
Heart Failure
Reduced lymphocyte stimulatory guanine nucleotide regulatory protein and beta-adrenergic receptors in congestive heart failure and reversal with angiotensin converting enzyme inhibitor therapy.
Heart Failure
Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium.
Heart Failure
Regulation and possible functional implications of G-protein mRNA expression in nonfailing and failing ventricular myocardium.
Heart Failure
Regulation of cyclic adenosine monophosphate release by selective ?(2)-adrenergic receptor stimulation in human terminal failing myocardium before and after ventricular assist device support.
Heart Failure
Regulation of the human Gi alpha-2 gene promotor activity in embryonic chicken cardiomyocytes.
Heart Failure
Restoration of myocardial beta-adrenergic receptor signaling after left ventricular assist device support.
Heart Failure
Reversible contractile dysfunction in reversible experimental cardiac allograft rejection: alterations in the beta-receptor-stimulated adenylylcyclase pathway.
Heart Failure
Role of G-proteins in altered beta-adrenergic responsiveness in the failing and hypertrophied myocardium.
Heart Failure
Skeletal muscle beta-receptors and isoproterenol-stimulated vasodilation in canine heart failure.
Heart Failure
Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress.
Heart Failure
The cardiac beta-adrenoceptor-mediated signaling pathway and its alterations in hypertensive heart disease.
Heart Failure
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
Heart Failure
Transregulation of adenylyl-cyclase-coupled inhibitory receptors in heart failure enhances anti-adrenergic effects on adult rat cardiomyocytes.
Heart Failure
Uncoupling of G-protein coupled receptors in vivo: insights from transgenic mice.
Heart Failure
Urocortin-2 induces vasorelaxation of coronary arteries isolated from patients with heart failure.
Heart Failure
[Control mechanisms of renal functions: effects of cardiovascular drugs on vasoconstrictive and antinatriuretic stimuli in the in vivo kidney]
Hematologic Diseases
[Adenyl cyclase activity of human blood platelets in various blood diseases]
Hematoma, Subdural, Acute
Early changes in second messenger but not receptor binding sites after acute subdural hematoma: an in vitro autoradiographic study.
Hemiplegia
Alternating Hemiplegia of Childhood as a New Presentation of Adenylate Cyclase 5-Mutation-Associated Disease: A Report of Two Cases.
Hepatic Encephalopathy
Lack of evidence for impaired dopamine receptor function in experimental hepatic coma in the rabbit.
Hepatitis
Genetic polymorphisms of regulatory T cell-related genes modulate systemic inflammation induced by viral hepatitis.
Hepatitis
[Changes in the adenylate cyclase system of rat liver cells in acute experimental hepatitis and ways of correcting them]
Hepatitis B, Chronic
Plasma pituitary adenylate cyclase activating polypeptide (PACAP) levels in chronic hepatitis B patients under lamivudine treatment.
Hepatitis B, Chronic
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Hereditary Sensory and Motor Neuropathy
Charcot?Marie?Tooth type 1A drug therapies: role of adenylyl cyclase activity and G?protein coupled receptors in disease pathomechanism.
Herpes Simplex
Long-term increases in neurotransmitter release from neuronal cells expressing a constitutively active adenylate cyclase from a herpes simplex virus type 1 vector.
Herpes Simplex
The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency.
Herpes Zoster
Alpha-melanocyte-stimulating hormone-induced inhibition of angiotensin II receptor-mediated events in the rat adrenal zona glomerulosa.
Herpes Zoster
Angiotensin stimulates adenylate cyclase activity via prostaglandins in the adrenal glomerulosa membrane.
Herpes Zoster
Autoradiographic localization of neuroleptic and dopamine receptors in the caudate-putamen and substantia nigra: effects of lesions.
Herpes Zoster
Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current.
Herpes Zoster
Dopamine-sensitive adenylate cyclase occurs in a region of substantia nigra containing dopaminergic dendrites.
Herpes Zoster
Effects of chronic treatment with adrenocorticotropin on adenylate cyclase activity in the adrenal cortex.
Herpes Zoster
Effects of protease inhibitors on adenylate cyclase activation and aldosterone production in rat adrenal zona glomerulosa cells.
Herpes Zoster
Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland.
Herpes Zoster
Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida.
Herpes Zoster
Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.
Herpes Zoster
Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat.
Herpes Zoster
Inhibitory effects of bromocriptine on corticosterone secretion in male rats.
Herpes Zoster
Mouse sperm adenylyl cyclase: general properties and regulation by the zona pellucida.
Herpes Zoster
Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth.
Herpes Zoster
Stimulation of steroidogenesis by forskolin in rat adrenal zona glomerulosa cell preparations.
Herpes Zoster
Studies on cyclic nucleotides in the adrenal gland. VIII. Effects of angiotensin on adenosine 3',5'-monophosphate and steroidogenesis in the adrenal cortex.
Herpes Zoster
Studies on cyclic nucleotides in the adrenal gland. X. Effects of adrenocorticotropin and prostaglandin on adenylate cyclase activity in the adrenal cortex.
Herpes Zoster
Studies on cyclic nucleotides in the adrenal gland. XI. Adrenergic regulation of adenylate cyclase activity in the adrenal cortex.
HIV Infections
Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.
Huntington Disease
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Hutchinson's Melanotic Freckle
Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins.
Hutchinson's Melanotic Freckle
Investigation of cAMP microdomains as a path to novel cancer diagnostics.
Hutchinson's Melanotic Freckle
Melanocytic soluble adenylyl cyclase protein expression around lentigo maligna and in contralateral control skin.
Hutchinson's Melanotic Freckle
Soluble Adenylyl Cyclase Antibody (R21) as a Diagnostic Adjunct in the Evaluation of Lentigo Maligna Margins During Slow Mohs Surgery.
Hyperalgesia
Activation of the cAMP transduction cascade contributes to the mechanical hyperalgesia and allodynia induced by intradermal injection of capsaicin.
Hyperalgesia
Adenylate cyclase inhibition attenuates neuropathic pain but lacks pre-emptive effects in rats.
Hyperalgesia
Allosteric interactions between ? and ? opioid receptors in peripheral sensory neurons.
Hyperalgesia
Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.
Hyperalgesia
Chronic hyperalgesic priming in the rat involves a novel interaction between cAMP and PKCepsilon second messenger pathways.
Hyperalgesia
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Hyperalgesia
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Hyperalgesia
Is there more than one prostaglandin E receptor subtype mediating hyperalgesia in the rat hindpaw?
Hyperalgesia
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Hyperalgesia
Mu-opioid agonist enhancement of prostaglandin-induced hyperalgesia in the rat: a G-protein beta gamma subunit-mediated effect?
Hyperalgesia
Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.
Hyperalgesia
Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections.
Hyperalgesia
Primary afferent second messenger cascades interact with specific integrin subunits in producing inflammatory hyperalgesia.
Hyperalgesia
Regulation of ?-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo.
Hyperalgesia
Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo.
Hyperalgesia
Sensitization of spinal cord nociceptive neurons with a conjugate of substance P and cholera toxin.
Hyperalgesia
Stimulation of deep somatic tissue with capsaicin produces long-lasting mechanical allodynia and heat hypoalgesia that depends on early activation of the cAMP pathway.
Hyperalgesia
Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain.
Hypercalcemia
Comparison of postreceptor effects of 1-34 human hypercalcemia factor and 1-34 human parathyroid hormone in rat osteosarcoma cells.
Hypercalcemia
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Hypercalcemia
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.
Hypercalcemia
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.
Hypercalcemia
Lithiumogenic disorders of the thyroid and parathyroid glands as surgical disease.
Hypercalcemia
Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity.
Hypercalcemia
Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.
Hypercalcemia
Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins.
Hypercalcemia
Sulfur-free parathyroid hormone analogues containing D-amino acids: biological properties in vitro and in vivo.
Hypercalcemia
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
Hypercholesterolemia
Effects of PGI2 on platelet aggregation and adenylate cyclase activity in human type IIa hypercholesterolemia.
Hypercholesterolemia
Hypercholesterolemia is associated with a reduced response of smooth muscle guanylyl cyclase to nitrovasodilators.
Hyperglycemia
ADCY5 gene expression in adipose tissue is related to obesity in men and mice.
Hyperglycemia
Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.
Hyperglycemia
Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice.
Hyperglycemia
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.
Hyperglycemia
Effects of alpha- and beta-adrenergic blockers on chlorpromazine-induced elevation of plasma glucose and cyclic AMP in fed mice.
Hyperglycemia
Functional coupling of hormone receptors with G proteins in the adenylate cyclase system of the rat muscle tissues and brain under conditions of short-term hyperglycemia.
Hyperglycemia
Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.
Hyperglycemia
Glycogenolytic activity of pituitary adenylate cyclase activating polypeptide (PACAP) in vivo and in vitro.
Hyperglycemia
Modulation of G-protein expression and adenylyl cyclase signaling by high glucose in vascular smooth muscle.
Hyperglycemia
Novel mechanism of increasing cerebral vascular constriction in acute hyperglycemia and diabetes through adenylyl cyclase 5-generated cyclic adenosine monophosphate.
Hyperglycemia
Synthesis of two glucagon antagonists: receptor binding, adenylate cyclase, and effects on blood plasma glucose levels.
Hyperglycemia
The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase.
Hyperglycemia
Variations in functional activity of the hormone-sensitive adenylate cyclase system in tissues of gastropod mollusks with streptozotocin-induced diabetes.
Hyperhidrosis
Mahuannin B an adenylate cyclase inhibitor attenuates hyperhidrosis via suppressing ?2-adrenoceptor/cAMP signaling pathway.
Hyperinsulinism
Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice.
Hyperinsulinism
An impaired response of adenylate cyclase to stimulation by epinephrine in adipocyte plasma membranes from genetically obese mice (ob/ob).
Hyperinsulinism
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.
Hyperinsulinism
The effects of in vitro and in vivo exposure to insulin upon prostaglandin E1 stimulation of platelet adenylate cyclase activity in healthy subjects.
Hyperinsulinism
The response of adenylate cyclase to ACTH in adipocyte membranes of lean and obese mice.
Hyperkinesis
ADCY5-Related Dyskinesia: Improving Clinical Detection of an Evolving Disorder.
Hyperkinesis
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Hyperkinesis
An Update on the Phenotype, Genotype and Neurobiology of ADCY5-Related Disease.
Hyperkinesis
Deep brain stimulation reduces (nocturnal) dyskinetic exacerbations in patients with ADCY5 mutation: a case series.
Hyperkinesis
Protein kinase A signalling in Schistosoma mansoni cercariae and schistosomules.
Hyperkinesis
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
Hyperlipoproteinemias
Decreased number of PGD2 binding sites on platelets from patients with type IIa hyperlipoproteinemia.
Hyperparathyroidism
Altered adenylate cyclase kinetics in hyperfunctioning human parathyroid glands.
Hyperparathyroidism
Effects of dietary-induced hyperparathyroidism on the parathyroid hormone-receptor-adenylate cyclase system of canine kidney. Evidence for postreceptor mechanism of desensitization.
Hyperparathyroidism
Lithiumogenic disorders of the thyroid and parathyroid glands as surgical disease.
Hyperparathyroidism
Peripheral metabolism of parathyroid hormone in patients with primary hyperparathyroidism as judged by immunological and biological studies.
Hyperparathyroidism, Primary
Adenylate cyclase activity in human parathyroid tissues: reduced sensitivity to suppression by calcium in parathyroid adenomas as compared with normal glands form normocalcemic subjects or noninvolved glands from hyperparathyroid subjects.
Hyperparathyroidism, Primary
Peripheral metabolism of parathyroid hormone in patients with primary hyperparathyroidism as judged by immunological and biological studies.
Hyperparathyroidism, Primary
The effect of parathyroid hormone (PTH) and 24,25-dihydroxy-vitamin D3 on adenylyl cyclase of iliac crest biopsies: diagnostic and prognostic tool for evaluation and treatment of uremic patients.
Hyperparathyroidism, Secondary
Abnormal skeletal response to parathyroid hormone in dogs with chronic uremia.
Hyperparathyroidism, Secondary
Activation of renal adenylate cyclase by forskolin: assessment of enzymatic activity in animal models of the secondary hyperparathyroid state.
Hyperparathyroidism, Secondary
An adenylate cyclase bioassay for parathyroid hormone: some clinical experiences.
Hyperparathyroidism, Secondary
Impaired parathyroid hormone-stimulated adenosine 3',5'-monophosphate release by isolated perfused bones obtained from vitamin D-deficient rats.
Hyperparathyroidism, Secondary
Influence of the amino-terminus on in vitro and in vivo biological activity of synthetic parathyroid hormone-like peptides of malignancy.
Hyperparathyroidism, Secondary
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Hyperphosphatemia
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Hypersensitivity
Absence of metabotropic glutamate receptor homolog(s) accelerates acetylcholine neurotransmission in Caenorhabditis elegans.
Hypersensitivity
Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children.
Hypersensitivity
beta-Adrenoceptor regulation in rat heart, lung and skin after chronic treatment with (--)-tertatolol or (--)-propranolol.
Hypersensitivity
Catecholamine hypersensitivity of adenylate cyclase after chemical denervation in rat heart.
Hypersensitivity
Differential effect of repeated treatment with L-dopa on dopamine-D1 or -D2 receptors.
Hypersensitivity
Effect of epinephrine on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in control and antigen-sensitized guinea pig lungs.
Hypersensitivity
Effect of long-term and short-term diabetes on the parathyroid hormone sensitive rat renal adenylate cyclase: correlation with vitamin D metabolism.
Hypersensitivity
Hypersensitivity of Gi protein mediated muscarinic receptor adenylyl cyclase in chronic ischaemic heart failure in the rat.
Hypersensitivity
Hypersensitivity to histamine in the guinea-pig brain: microiontophoretic and biochemical studies.
Hypersensitivity
Hypersensitivity to isoproterenol in rabbit heart decreases guanine nucleotide effect on adenylate cyclase.
Hypersensitivity
In vivo partial inactivation of dopamine D1 receptors induces hypersensitivity of cortical dopamine-sensitive adenylate cyclase: permissive role of alpha 1-adrenergic receptors.
Hypersensitivity
L-3,4-dihydroxyphenylalanine-induced hypersensitivity simulating features of denervation.
Hypersensitivity
Levels of stimulatory G protein are increased in the rat striatum after neonatal lesion of dopamine neurons.
Hypersensitivity
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.
Hypersensitivity
Neuropeptide Y tonically inhibits an NMDAR?AC1?TRPA1/TRPV1 mechanism of the affective dimension of chronic neuropathic pain.
Hypersensitivity
Non-DA prefronto-cortical efferents modulate D1 receptors in the nucleus accumbens.
Hypersensitivity
Regulation of adenylyl cyclase by noradrenaline and tumour necrosis factor alpha in rat cardiomyocytes.
Hypersensitivity
Role of opiates in striatal D-1 dopamine receptor supersensitivity induced by chronic L-dopa treatment.
Hypersensitivity
The antiglucocorticoid RU38486 is a potent accelerator of adipose conversion of 3T3-F442A cells.
Hypersensitivity
[Comparison of fenoterol (Berotec) with the antiallergic benzopyrene compound PR-D 92 and a placebo in regard to the cutaneous immediate reaction in allergic patients (author's transl)]
Hypersensitivity
[Development of cardiac adenylate cyclase hypersensitivity to isoproterenol in the chronic action of propranolol on rats]
Hypersensitivity
[Development of desensitization and hypersensitivity of the adenyl cyclase system of the heart to the action of hormones]
Hypersensitivity
[Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease]
Hypersensitivity, Immediate
Forskolin inhibits the release of histamine from human basophils and mast cells.
Hypersensitivity, Immediate
Inhibition of IgE-mediated histamine release from human basophils and mast cells by fenoterol.
Hypersensitivity, Immediate
Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin.
Hypertension
Aberrant adenylyl cyclase/cAMP signal transduction and G protein levels in platelets from hypertensive patients improve with antihypertensive drug therapy.
Hypertension
Adenylate cyclase activity during development and reversal of cardiac hypertrophy.
Hypertension
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension.
Hypertension
Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.
Hypertension
Beta-adrenergic signal transduction in the failing and hypertrophied myocardium.
Hypertension
Beta-andrenoceptors in the hearts of diabetic-hypertensive rats: radioligand binding and functional experiments.
Hypertension
Calcium-dependent proteolytic stimulation of adenylate cyclase in platelets from spontaneously hypertensive rats.
Hypertension
Cardiac adenylyl cyclase, beta-adrenergic receptors, and G proteins in salt-sensitive hypertension.
Hypertension
Comparative effects of alpha-methyldopa, propranolol and hydralazine therapy on cardiac adenylate cyclase activity in normal and spontaneously hypertensive rats.
Hypertension
Cross-talk between cardiac kappa-opioid and beta-adrenergic receptors in developing hypertensive rats.
Hypertension
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertension.
Hypertension
Differential regulation of ANF-R2 receptors coupled to adenylyl cyclase in cardiovascular tissues in hypertension.
Hypertension
Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension.
Hypertension
Dual mechanisms involved in development of diverse biological activities of islet-activating protein, pertussis toxin, as revealed by chemical modification of lysine residues in the toxin molecule.
Hypertension
Effects of forskolin on inotropic performance and phospholamban phosphorylation in exercise-trained hypertensive myocardium.
Hypertension
Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat.
Hypertension
Forskolin-stimulated adenylyl cyclase activity is decreased but beta 2-adrenoceptor function is unchanged in primary hypertension.
Hypertension
Glandular adenylate cyclase system in genetic hypertension: age-dependent response to catecholamines.
Hypertension
Guanine nucleotide regulatory protein levels and function in spontaneously hypertensive rat vascular smooth-muscle cells.
Hypertension
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology.
Hypertension
Hormonal modulation of intracellular free calcium in platelets from normotensive and hypertensive subjects.
Hypertension
Increased forskolin stimulation of lymphocyte-adenylate cyclase in normotensive subjects predisposed to essential hypertension.
Hypertension
Inotropic response to norepinephrine is augmented early and maintained late in conscious dogs with perinephritic hypertension.
Hypertension
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Hypertension
Low-dose angiotensin II reduces urinary cyclic AMP excretion in spontaneously hypertensive, but not normotensive, rats: independence from hypertension and renal hemodynamic effects of angiotensin.
Hypertension
Modulation by angiotensin II of isoproterenol-induced cAMP production in preglomerular microvascular smooth muscle cells from normotensive and genetically hypertensive rats.
Hypertension
Myocardial adrenergic receptors and adenylate cyclase in the developing spontaneously hypertensive rat.
Hypertension
Nephron specificity of dopamine receptor-adenylyl cyclase defect in spontaneous hypertension.
Hypertension
Nitric oxide synthase inhibition by N(omega)-nitro-L-arginine methyl ester modulates G-protein expression and adenylyl cyclase activity in rat heart.
Hypertension
Ontogenetic development of isoproterenol subsensitivity of myocardial adenylate cyclase and beta-adrenergic receptors in spontaneously hypertensive rats.
Hypertension
Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclase.
Hypertension
PACAP causes PAC1/VPAC2 receptor mediated hypertension and sympathoexcitation in normal and hypertensive rat.
Hypertension
Pharmacological characterization of vasorelaxant effects of BMS-180448, a novel cardioselective ATP-sensitive potassium channel opener, in rat aorta.
Hypertension
Plasma cyclic adenosine 3':5'-monophosphate response to isoproterenol and glucagon in hyperkinetic borderline (labile) hypertension.
Hypertension
Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat.
Hypertension
Receptor-cyclase coupling protein in erythrocytes of patients with essential hypertension.
Hypertension
Receptor-independent sensitization of the adenylyl cylase after chronic treatment with cyclosporine A.
Hypertension
Regulation of the lymphocyte adenylate cyclase system by prostaglandin E2 infusions in resistant hypertensive subjects.
Hypertension
Regulation of vasopressin receptors in deoxycorticosterone acetate-salt hypertension.
Hypertension
Role of G-proteins in altered beta-adrenergic responsiveness in the failing and hypertrophied myocardium.
Hypertension
Secretin and VIP-stimulated adenylate cyclase from rat heart. II. Impairment in spontaneous hypertension.
Hypertension
Supersensitivity of beta-adrenoceptor coupled adenylate cyclase in pulmonary tissue of the spontaneously hypertensive rat.
Hypertension
The activity of adenylate cyclase and phosphodiesterase in the isoproterenol-damaged cardiac muscle of spontaneously hypertensive rats.
Hypertension
The cardiac and brain microvessel adenylate cyclase system in deoxycorticosterone acetate-hypertensive rats.
Hypertension
Vascular beta-adrenergic receptor adenylyl cyclase system from renin-transgenic hypertensive rats.
Hypertension
[ACTH-adenylate cyclase in adipose cell "ghosts" of rats with spontaneous hypertension (effect of adrenalectomy)]
Hypertension
[Decrease in adenylate cyclase sensitivity to sodium ions in lymphocytes of patients with arterial hypertension]
Hypertension
[Effect of isoproterenol on adenylate cyclase activity in the adipocytes of rats with spontaneous genetic hypertension]
Hypertension
[Regulation of the adenylate cyclase system of lymphocytes in patients with therapy-resistant arterial hypertension and during PGE2 administration]
Hypertension
[Status of the adrenergic beta 2 receptor-dependent adenylate cyclase system of lymphocytes in patients with hypertension and left-ventricular hypertrophy of different degree of severity]
Hypertension
[The effect of a submaximal physical load on the beta 2-adrenoreceptor-dependent adenylate cyclase system of the lymphocytes in hypertension]
Hypertension
[The effect of obzidan and visken on the regulation of the lymphocyte beta 2-adrenoreceptor adenylate cyclase system during physical loading in hypertension patients]
Hypertension
[The effect of obzidan monotherapy on the beta 2-adrenoreceptors of the lymphocyte adenylate cyclase system in hypertension patients]
Hypertension, Pulmonary
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Hypertension, Pulmonary
Changes in the receptor-G protein-adenylyl cyclase system in heart failure from various types of heart muscle disease.
Hypertension, Pulmonary
Expression of Vasoactive Intestinal Peptide and Related Receptors in Overcirculation-Induced Pulmonary Hypertension in Piglets.
Hypertension, Pulmonary
Hypoxia Inhibits Adenylyl Cyclase Catalytic Activity in a Porcine Model of Persistent Pulmonary Hypertension of the Newborn.
Hypertension, Pulmonary
Prostacyclin production and mediation of adenylate cyclase activity in the pulmonary artery. Alterations after prolonged hypoxia in the rat.
Hypertension, Pulmonary
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry.
Hypertension, Renal
Altered hormone sensitivity of adenylate cyclase in myocardial sarcolemma of renal hypertensive rats.
Hypertension, Renal
Preserved cardiac beta-adrenergic sensitivity in early renovascular hypertension.
Hypertension, Renal
[Properties of adenylate cyclase system in heart muscle and aorta of rats with experimental renal hypertension]
Hypertension, Renovascular
Preserved cardiac beta-adrenergic sensitivity in early renovascular hypertension.
Hypertension, Renovascular
[Properties of adenylate cyclase system in heart muscle and aorta of rats with experimental renal hypertension]
Hyperthyroidism
Adrenergic binding sites and enzyme activities in the heart of hyperthyroid rats.
Hyperthyroidism
Adrenergic regulation of lipolysis in fat cells from hyperthyroid and hypothyroid patients.
Hyperthyroidism
Altered thyroid status regulates the adipocyte A1 adenosine receptor-adenylate cyclase system.
Hyperthyroidism
Beta-adrenoceptor-agonist and insulin actions on glucose metabolism in rat skeletal muscle in different thyroid states.
Hyperthyroidism
Catecholamine, vasoactive intestinal peptide and thyrotrophin-dependent cAMP levels display a different sensitivity to iodothyronines in both normal and pathological human thyroid cells in culture.
Hyperthyroidism
Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes.
Hyperthyroidism
Evidence that adenosine 3',5'-monophosphate mediates stimulation of thyroid growth in FRTL5 cells.
Hyperthyroidism
In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine.
Hyperthyroidism
Influence of exogenous ATP on blood sugar, serum insulin and serum free fatty acids in short-term experimental hyperthyroid dogs and in euthyroid controls.
Hyperthyroidism
Influence of hyperthyroidism on the effects of norepinephrine on myocardial adenyl cyclase activity and contractile state.
Hyperthyroidism
Influence of thyroid state on the specific binding of noradrenaline to a cardiac particulate fraction and on catecholamine-sensitive cardiac adenylate cyclase activity.
Hyperthyroidism
Influences of cholera toxin on thyroid stimulation by thyrotropin and thyroid-stimulating antibody.
Hyperthyroidism
Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.
Hyperthyroidism
Pregnancy-associated changes in the thyroid-stimulating antibody of Graves' disease and the relationship to neonatal hyperthyroidism.
Hyperthyroidism
Severe but not mild alterations of thyroid function modulate the density of thyroid-stimulating hormone receptors in the rat thyroid gland.
Hyperthyroidism
Short-term hyperthyroidism modulates adenosine receptors and catalytic activity of adenylate cyclase in adipocytes.
Hyperthyroidism
Simple and sensitive method for estimation of antithyroid plasma membrane antibodies in the serum of patients with autoimmune thyroid diseases; comparison with other assays.
Hyperthyroidism
Species differences in myocardial beta-adrenergic receptor regulation in response to hyperthyroidism.
Hyperthyroidism
Thyroid hormone differentially regulates development of beta-adrenergic receptors, adenylate cyclase and ornithine decarboxylase in rat heart and kidney.
Hyperthyroidism
Thyroid-stimulating hormone (TSH) receptor antibodies and antibodies stimulating adenyl cyclase in relatives from two families with a high prevalence of Graves' hyperthyroidism: a ten-year follow-up study.
Hyperthyroidism
[The posttranslational modification of thyrotropin receptor and thyroid diseases]
Hypertrophy, Left Ventricular
Adenylyl cyclase 6 deletion reduces left ventricular hypertrophy, dilation, dysfunction, and fibrosis in pressure-overloaded female mice.
Hypertrophy, Left Ventricular
Alteration of beta-adrenoceptor function in hypertensive patients with different degrees of left ventricular hypertrophy.
Hypertrophy, Left Ventricular
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
Hypertrophy, Left Ventricular
Decreased Gs alpha mRNA levels accompany the fall in Gs and adenylyl cyclase activities in compensated left ventricular hypertrophy. In heart failure, only the impairment in adenylyl cyclase activation progresses.
Hypertrophy, Left Ventricular
Functional activity and expression of the myocardial postreceptor adenylyl cyclase system in pressure overload hypertrophy in rat.
Hypertrophy, Left Ventricular
Myocardial hypertrophy, cardiac beta-adrenoceptors and adenylate cyclase activity during sinoaortic denervation in dogs.
Hypertrophy, Left Ventricular
Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy.
Hypertrophy, Left Ventricular
Relationship between adenylate cyclase activity and regional myocardial energetics in experimental left ventricular hypertrophy.
Hypertrophy, Left Ventricular
[Beta adrenergic receptors and experimental left ventricular hypertrophy]
Hypertrophy, Right Ventricular
Beta 1- and beta 2-receptors are differentially desensitized in an experimental model of heart failure.
Hypertrophy, Right Ventricular
Intraventricular changes in the beta-adrenoceptor-adenylate cyclase system of the rat heart with the progress of monocrotaline-induced right ventricular hypertrophy.
Hypocalcemia
Demonstration of a lack of change in serum 1 alpha,25-dihydroxyvitamin D in response to parathyroid extract in pseudohypoparathyroidism.
Hypocalcemia
Impaired parathyroid hormone-stimulated adenosine 3',5'-monophosphate release by isolated perfused bones obtained from vitamin D-deficient rats.
Hypocalcemia
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Hypoglycemia
Alterations of G-protein and adenylate cyclase signaling in rat liver during the progression of sepsis.
Hypoglycemia
Anomalous adenosine cyclic 3':5'-monophosphate responses to glucagon in patients with hepatocellular carcinoma.
Hypoglycemia
Enhanced reactivity of the adrenal medulla in response to pituitary adenylate cyclase activating polypeptide1-27 (PACAP) during insulin-induced hypoglycemia in anesthetized dogs.
Hypogonadism
The role of testicular adenylate cyclase in the hypogonadism of renal insufficiency.
Hypokinesia
Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram.
Hypokinesia
[Catecholamine concentration and adenyl cyclase and phosphodiesterase activities of the sarcolemma of myocardial cells during hypokinesia and in experimental information neuroses]
Hypokinesia
[The aspects of adenylate cyclase activity regulation in myocardium cell membranes during hypokinesia]
Hyponatremia
Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla.
Hypoparathyroidism
An adenylate cyclase bioassay for parathyroid hormone: some clinical experiences.
Hypophosphatemia, Familial
Mechanism of phosphaturia elicited by administration of phosphonoformate in vivo.
Hypophosphatemia, Familial
Parathyroid hormone metabolism and its potential as a uremic toxin.
Hypotension
Effects of renin-angiotensin blockade on sympathetic reactivity and beta-adrenergic pathway in the spontaneously hypertensive rat.
Hypotension
Neuronal nitric oxide synthase-dependent elevation in adiponectin in the rostral ventrolateral medulla underlies g protein-coupled receptor 18-mediated hypotension in conscious rats.
Hypotension
Specific decrease of secretin/VIP-stimulated adenylate cyclase in the heart from the Lyon strain of hypertensive rats.
Hypotension, Orthostatic
Plasma catecholamines and alpha- and beta-adrenoceptors in circulating blood cells in patients on continuous ambulatory peritoneal dialysis.
Hypothyroidism
Adrenergic regulation of lipolysis in fat cells from hyperthyroid and hypothyroid patients.
Hypothyroidism
Beta-adrenergic receptors, adenylate cyclase activation, and myofibril enzyme activity in hypothyroid rats.
Hypothyroidism
Beta-adrenoceptor-agonist and insulin actions on glucose metabolism in rat skeletal muscle in different thyroid states.
Hypothyroidism
Coupling defect of thyrotropin receptor and adenylate cyclase in a pseudohypoparathyroid patient.
Hypothyroidism
Cyclic AMP responses to parathyroid hormone and glucagon during lithium treatment.
Hypothyroidism
Decreased binding of vasoactive intestinal peptide to intestinal epithelial cells from hypothyroid rats.
Hypothyroidism
Effect of hypothyroidism on adenylyl cyclase activity and subtype gene expression in brown adipose tissue.
Hypothyroidism
Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes.
Hypothyroidism
Effects of thyroid deficiency on the vasopressin receptors in the kidney of developing and adult rats. A comparative study of hormonal binding and adenylate cyclase activation.
Hypothyroidism
Endocrinological Disorders Related to the Medical Use of Lithium. A Narrative Review.
Hypothyroidism
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology.
Hypothyroidism
Hypothyroidism alters the effect of GTP on adenylyl cyclase in forebrain and hindbrain synaptosomal membranes from 15-day-old rats.
Hypothyroidism
Hypothyroidism lowers blood pressure, adenylate cyclase and Na+, K+- and K+, Ca++-ATPase activities in normotensive and spontaneously hypertensive rats.
Hypothyroidism
Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes.
Hypothyroidism
Influence of thyroid state on the specific binding of noradrenaline to a cardiac particulate fraction and on catecholamine-sensitive cardiac adenylate cyclase activity.
Hypothyroidism
Inhibition of adenylate cyclase in rat brain synaptosomal membranes by GTP and phenylisopropyladenosine is enhanced in hypothyroidism.
Hypothyroidism
Lithiumogenic disorders of the thyroid and parathyroid glands as surgical disease.
Hypothyroidism
Steady-state levels of G-proteins and beta-adrenergic receptors in rat fat cells. Permissive effects of thyroid hormones.
Hypothyroidism
Thyroid hormone regulates ontogeny of beta adrenergic receptors and adenylate cyclase in rat heart and kidney: effects of propylthiouracil-induced perinatal hypothyroidism.
Hypothyroidism
Thyroid status affects the rat cardiac beta-adrenoceptor system transiently and time-dependently.
hypoxanthine phosphoribosyltransferase deficiency
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool.
Impotence, Vasculogenic
Intracavernosal forskolin: role in management of vasculogenic impotence resistant to standard 3-agent pharmacotherapy.
Inappropriate ADH Syndrome
Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla.
Infarction, Middle Cerebral Artery
Effect of middle cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat.
Infarction, Middle Cerebral Artery
Multimodal Neuroprotection Induced by PACAP38 in Oxygen-Glucose Deprivation and Middle Cerebral Artery Occlusion Stroke Models.
Infections
Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice.
Infections
Adenylate Cyclase AcyA Regulates Development, Aflatoxin Biosynthesis and Fungal Virulence in Aspergillus flavus.
Infections
Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice.
Infections
Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection.
Infections
Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.
Infections
Alteration of the pattern of beta-adrenergic desensitization in cultured L6E9 muscle cells infected with Trypanosoma cruzi.
Infections
Alterations in G-protein-regulated transmembrane signalling induced in murine myocardium by coxsackievirus B3 infection.
Infections
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signaling.
Infections
Antibodies to Bordetella pertussis adenylate cyclase are produced in man during pertussis infection and after vaccination.
Infections
Bacillus anthracis edema toxin inhibits hypoxic pulmonary vasoconstriction via edema factor and cAMP-mediated mechanisms in isolated perfused rat lungs.
Infections
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Infections
Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein.
Infections
Bordetella pertussis adenylate cyclase activity in nasopharyngeal aspirates for rapid diagnosis of whooping cough in relation to culture and serology.
Infections
Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.
Infections
Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.
Infections
Burn wound infection-induced myeloid suppression: the role of prostaglandin E2, elevated adenylate cyclase, and cyclic adenosine monophosphate.
Infections
cAMP and Vfr Control Exolysin Expression and Cytotoxicity of Pseudomonas aeruginosa Taxonomic Outliers.
Infections
Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease.
Infections
Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins.
Infections
Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size.
Infections
Cloning and characterization of genes specifically expressed during infection stages in the rice blast fungus.
Infections
Comparison of commercially available immunoblot assays measuring IgG and IgA antibodies to Bordetella pertussis antigens.
Infections
Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication.
Infections
Creutzfeldt-Jakob infection increases adenylate cyclase activity in specific regions of guinea pig brain.
Infections
Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation.
Infections
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
Infections
Determination of serum antibody to Bordetella pertussis adenylate cyclase toxin in vaccinated and unvaccinated children and in children and adults with pertussis.
Infections
EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin.
Infections
Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice.
Infections
Exoenzyme Y Contributes to End-Organ Dysfunction Caused by Pseudomonas aeruginosa Pneumonia in Critically Ill Patients: An Exploratory Study.
Infections
Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthrax.
Infections
Expression of mutationally activated G alpha s stimulates growth and differentiation of thyroid FRTL5 cells.
Infections
Filamin A is a phosphorylation target of plasma membrane but not cytosolic adenylyl cyclase activity.
Infections
Gastric pH and Toxin Factors Modulate Infectivity and Disease Progression After Gastrointestinal Exposure to Bacillus anthracis.
Infections
Infection of L6E9 myoblasts with Trypanosoma cruzi alters adenylate cyclase activity and guanine nucleotide binding proteins.
Infections
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Infections
Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.
Infections
Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.
Infections
Lymphocyte and macrophage adenyl cyclase activity in animals with enhanced cell-mediated resistance to infection and tumors.
Infections
Measles virus modulates human T-cell somatostatin receptors and their coupling to adenylyl cyclase.
Infections
Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region.
Infections
Murine innate immune response to virulent toxigenic and nontoxigenic Bacillus anthracis strains.
Infections
Mutation at different sites in the Nostoc punctiforme cyaC gene, encoding the multiple-domain enzyme adenylate cyclase, results in different levels of infection of the host plant Blasia pusilla.
Infections
Myocardial beta-adrenergic adenylate cyclase complex in a canine model of chagasic cardiomyopathy.
Infections
Non-canonical effects of anthrax toxins on hem atop oiesis: implications for vaccine development.
Infections
OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism.
Infections
Oxidant activated soluble adenylate cyclase of Leishmania donovani regulates the cAMP-PKA signaling axis for its intra-macrophage survival during infection.
Infections
Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract.
Infections
Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
Infections
Phosphoenolpyruvate Phosphotransferase System Components Modulate Gene Transcription and Virulence of Borrelia burgdorferi.
Infections
Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity.
Infections
Protective activity of Bordetella adenylate cyclase-hemolysin against bacterial colonization.
Infections
Quantifying Adenylate Cyclase Toxin of Bordetella pertussis in vitro and During Respiratory Infection.
Infections
Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair.
Infections
Respiratory syncytial virus induces ?2-adrenergic receptor dysfunction in human airway smooth muscle cells.
Infections
Revealing how an adenylate cyclase toxin uses bait and switch tactics in its activation.
Infections
Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Infections
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
Infections
Small Molecule Inhibitors of Bacillus anthracis Protective Antigen Proteolytic Activation and Oligomerization.
Infections
Small-Molecule Inhibitors of Lethal Factor Protease Activity Protect against Anthrax Infection.
Infections
Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.
Infections
Susceptibility of primary human airway epithelial cells to Bordetella pertussis adenylate cyclase toxin in two- and three-dimensional culture conditions.
Infections
Testing the efficacy and toxicity of adenylyl cyclase inhibitors against enteric pathogens using in vitro and in vivo models of infection.
Infections
The adenylate cyclase (BAC) in Botrytis cinerea is required for full pathogenicity.
Infections
The adenylyl cyclase Rv2212 modifies the proteome and infectivity of Mycobacterium bovis BCG.
Infections
The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse.
Infections
The Borrelia burgdorferi Adenylate Cyclase, CyaB, Is Important for Virulence Factor Production and Mammalian Infection.
Infections
The Coxiella burnetii Cryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates.
Infections
The Cyclase-Associated Protein Cap1 Is Important for Proper Regulation of Infection-Related Morphogenesis in Magnaporthe oryzae.
Infections
The interaction of signal transduction pathways in FRTL5 thyroid follicular cells: studies with stable expression of beta 2-adrenergic receptors.
Infections
The trypanosome VSG expression site encodes adenylate cyclase and a leucine-rich putative regulatory gene.
Infections
Trypanosoma cruzi: alteration of cAMP metabolism following infection of human endothelial cells.
Infections
Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.
Infections
Verapamil ameliorates clinical, pathologic and biochemical manifestations of experimental chagasic cardiomyopathy in mice.
Infections
Vibrio cholerae Infection of Drosophilamelanogaster Mimics the Human Disease Cholera.
Infections
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
Infections
VPAC1 is a cellular neuroendocrine receptor expressed on T cells that actively facilitates productive HIV-1 infection.
Infections
[Role of histamine receptors of mouse and guinea pig peritoneal leukocytes in the pathogenetic effect of Yersinia pestis adenylate cyclase]
Infections
[Ultracytochemical localization of intracellular adenylate cyclase activity in gonococcal infection]
Infections
[Ultracytochemistry of phosphohydrolase of the microorganisms and phagocytes in gonococcal infection]
Infertility
Involvement of Moc1 in sexual development and survival of Schizosaccharomyces pombe.
Infertility, Male
Correlation between the sperm motility and the adenylate cyclase activity in infertile men.
Influenza, Human
Heterosubtypic protection against influenza A induced by adenylate cyclase toxoids delivering conserved HA2 subunit of hemagglutinin.
Influenza, Human
Induction of neutralizing antibody responses to anthrax protective antigen by using influenza virus vectors: implications for disparate immune system priming pathways.
Influenza, Human
Interaction of plasma membranes with influenza virus. VI. The possible role of the adenylate cyclase system.
Influenza, Human
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
Insulin Resistance
Adenylyl cyclase 3 haploinsufficiency confers susceptibility to diet-induced obesity and insulin resistance in mice.
Insulin Resistance
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance.
Insulin Resistance
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Insulin Resistance
Direct Effect of the Synthetic Analogue of Glucagon-Like Peptide Type 1, Liraglutide, on Mature Adipocytes Is Realized through Adenylate-Cyclase-Dependent Enhancing of Insulin Sensitivity.
Insulin Resistance
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Insulin Resistance
Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesity.
Insulin Resistance
Obesity-induced p53 activation in insulin-dependent and independent tissues is inhibited by beta-adrenergic agonist in diet-induced obese rats.
Insulin Resistance
Regulation of cyclic AMP synthesis and degradation is modified in rat liver at late gestation.
Insulin Resistance
Selective alteration of secretin-stimulated cardiac adenylate cyclase activity in streptozotocin-diabetic rats.
Insulin Resistance
[Effects of supplemented taohe chengqi decoction in treating insulin resistance in rats with non-insulin dependent diabetes mellitus]
Insulinoma
Characterization of specific calcitonin gene-related peptide receptors present in hamster pancreatic beta cells.
Insulinoma
Development of PACAP38 Analogue with Improved Stability: Physicochemical and In Vitro/In Vivo Pharmacological Characterization.
Insulinoma
Effect of estradiol on insulin secreting INS-1 cells overexpressing estrogen receptors.
Insulinoma
Evidence of functional gastric inhibitory polypeptide (GIP) receptors in human insulinoma. Binding of synthetic human GIP 1-31 and activation of adenylate cyclase.
Insulinoma
Glucagon acts through its own receptors in the presence of functional glucagon-like peptide-1 receptors on hamster insulinoma.
Insulinoma
Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate.
Insulinoma
Inhibition of adenylate cyclase activity by galanin in rat insulinoma cells is mediated by the G-protein Gi3.
Insulinoma
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
Insulinoma
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
Intellectual Disability
Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability.
Ischemic Attack, Transient
Post- and presynaptic lesions in the CA1 region of hippocampus: effect on [3H]forskolin and [3H]phorboldibutyrate ester binding.
Joint Dislocations
Evaluation of the Clavicle Hook Plate for Treatment of Acromioclavicular Joint Dislocation: A Cadaveric Study.
Joint Dislocations
High Early-onset acromioclavicular secondary pathologies after acute arthroscopic joint reduction: a cohort study.
Joint Dislocations
Open capsular and ligament reconstruction with semitendinosus hamstring autograft successfully controls superior and posterior translation for type V acromioclavicular joint dislocation.
Joint Dislocations
Surgical treatment of acute type V acromioclavicular joint dislocations in professional athletes: an anatomic ligament reconstruction with synthetic implant augmentation.
Joint Dislocations
Transacromial extra-articular Knowles pin fixation treatment of acute type V acromioclavicular joint injuries.
Kidney Failure, Chronic
Adenylate cyclase of gastric mucosa in patients with chronic renal failure.
Kidney Failure, Chronic
Platelet adenylyl cyclase signaling remains unaltered in children undergoing hemodialysis treatment.
Kidney Failure, Chronic
PTH activity as determined by canine renal cortical adenylate cyclase assay in chronic renal failure.
Kidney Failure, Chronic
Unchanged hormone sensitivity of rat fat cell adenylate cyclase in uremia.
Kidney Failure, Chronic
Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA.
Leiomyoma
Changes in beta(2)-adrenoceptor expression and in adenylyl cyclase and phosphodiesterase activity in human uterine leiomyomas.
Leiomyoma
Impairment of adenylate cyclase activity and G-proteins in human uterine leiomyoma.
Leishmaniasis
Inhibition of expression of major histocompatibility complex class II molecules in macrophages infected with Leishmania donovani occurs at the level of gene transcription via a cyclic AMP-independent mechanism.
Lesch-Nyhan Syndrome
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool.
Leukemia
Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.
Leukemia
Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
Leukemia
Beta-adrenergic influences on doxorubicin-sensitive or -resistant P388 leukemia cells.
Leukemia
Combined action of stem cell factor, leukemia inhibitory factor, and cAMP on in vitro proliferation of mouse primordial germ cells.
Leukemia
Effect of high doses of somatostatin on adenylate cyclase activity in peripheral mononuclear leukocytes from normal subjects and from acute leukemia patients.
Leukemia
Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells.
Leukemia
Glycerophosphoinositols as potential markers of ras-induced transformation and novel second messengers.
Leukemia
Physicochemical characterization of substituted chromeno[4,3-b][1,5]benzodiazepine stereoisomers designed as cell membrane active antitumor agents.
Leukemia
Physiochemical characterization of substituted chromeno[4,3-b][1,5]benzodiazepine stereoisomers designed as cell membrane active antitumor agents.
Leukemia
Properties of vasoactive-intestinal-peptide receptors and beta-adrenoceptors in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.
Leukemia
Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase.
Leukemia
Somatostatin analog SMS 201995 inhibits proliferation in human leukemia T-cell line: relevance of the adenylyl cyclase stimulation.
Leukemia
Stimulation and inhibition of rat basophilic leukemia cell adenylate cyclase by forskolin.
Leukemia
[Activation of adenylate cyclase influences the sensitivity of acute promyelocytic leukemia cell lines to ATRA.]
Leukemia, Erythroblastic, Acute
A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.
Leukemia, Erythroblastic, Acute
Adenylate cyclase coupled beta adrenergic receptors of Rauscher erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Alpha 2-adrenergic receptor stimulation mobilizes intracellular Ca2+ in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Chronic ethanol treatment reduces adenylyl cyclase activity in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Compartmentation of alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells.
Leukemia, Erythroblastic, Acute
Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion.
Leukemia, Erythroblastic, Acute
Coupling of receptors in brain membranes by fusion to the adenylate cyclase system of a foreign effector cell.
Leukemia, Erythroblastic, Acute
Influence of the beta-adrenergic receptor concentration on functional coupling to the adenylate cyclase system.
Leukemia, Erythroblastic, Acute
Interaction between alpha 2-adrenergic and NPY receptor pathways in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16.
Leukemia, Erythroblastic, Acute
Neuropeptide Y mobilizes Ca2+ and inhibits adenylate cyclase in human erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Pharmacological characterization of adenosine A2B receptors: studies in human mast cells co-expressing A2A and A2B adenosine receptor subtypes.
Leukemia, Erythroblastic, Acute
The beta-adrenergic receptor adenylate cyclase complex of Rauscher murine erythroleukemia cells and its response to erythropoietin-induced differentiation.
Leukemia, Lymphocytic, Chronic, B-Cell
Adenylate cyclase and guanylate cyclase activity in normal and leukemic human lymphocytes.
Leukemia, Lymphocytic, Chronic, B-Cell
Adenylate cyclase in thymus-derived and bone marrow-derived lymphocytes from normal donors and patients with chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation.
Leukemia, Lymphocytic, Chronic, B-Cell
Vasoactive intestinal polypeptide modulation of lymphocyte adenylate cyclase.
Leukemia, Myeloid
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Leukemia, Myeloid
Restoration of adenylate cyclase responsiveness in murine myeloid leukemia permits inhibition of proliferation by hormone. Butyrate augments catalytic activity of adenylate cyclase.
Leukemia, Myeloid
To the mechanism of spermine-FBS cytotoxicity toward K562 human myelogenous leukemia cells.
Leukemia, Myeloid, Acute
Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Suppression of the delayed rectifier type of voltage gated K+ outward current in megakaryocytes from patients with myelogenous leukemias.
Leukemia, Promyelocytic, Acute
Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
Leukemia, Promyelocytic, Acute
[Activation of adenylate cyclase influences the sensitivity of acute promyelocytic leukemia cell lines to ATRA.]
Leukemia, T-Cell
Distinct mechanisms for K+ efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin.
Leydig Cell Tumor
A transplantable rat Leydig cell tumor--2. Adenylyl cyclase activation by prostaglandin E1, isoproterenol and glucagon.
Leydig Cell Tumor
A transplantable rat Leydig cell tumor--3. Isoproterenol and prostaglandin E1 (PGE1) responsive adenylyl cyclase (AC). Regulatory effects of nucleotides and magnesium.
Leydig Cell Tumor
A transplantable rat Leydig cell tumor--5. Cellular localization of beta-adrenergic and prostaglandin receptors and their effects on testosterone production.
Leydig Cell Tumor
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Leydig Cell Tumor
Guanine nucleotide mediated desensitization of adenylate cyclase in cell free preparations from a Leydig cell tumour.
Leydig Cell Tumor
Isolation and characterization of plasma membranes containing LH sensitive adenylate cyclase from a Leydig cell tumour.
Lipoma
Adenylate cyclase of multiple lipomata. Regional differences in adrenaline-responsiveness.
Lipoma
Are the metabolic characteristics of congenital intraspinal lipoma cells identical to, or different from normal adipocytes?
Lipomatosis
Adenylate cyclase of multiple lipomata. Regional differences in adrenaline-responsiveness.
Lipomatosis
Adipocyte adenylate cyclase and alpha- and beta-adrenergic receptors in one case of multiple symmetric lipomatosis.
Lipomatosis, Multiple Symmetrical
Adenylate cyclase of multiple lipomata. Regional differences in adrenaline-responsiveness.
Lipomatosis, Multiple Symmetrical
Adipocyte adenylate cyclase and alpha- and beta-adrenergic receptors in one case of multiple symmetric lipomatosis.
Liver Cirrhosis
Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis.
Liver Cirrhosis
Dopamine-sensitive adenylate cyclase activity in the caudate nucleus and adrenal medulla in Parkinson's disease and in liver cirrhosis.
Liver Cirrhosis, Biliary
Role of the bicarbonate-responsive soluble adenylyl cyclase in cholangiocyte apoptosis in primary biliary cholangitis; a new hypothesis.
Liver Cirrhosis, Biliary
The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis.
Liver Diseases
Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.
Liver Failure, Acute
Lack of evidence for impaired dopamine receptor function in experimental hepatic coma in the rabbit.
Liver Neoplasms, Experimental
Comparative adenylate cyclase activities in homogenate and plasma membrane fractions of Morris hepatoma 5123tc (h).
Liver Neoplasms, Experimental
Hormonal changes and adenylate cyclase system in rat bearing 7800 Morris hepatoma.
Lordosis
In the ventral tegmental area, cyclic AMP mediates the actions of progesterone at dopamine type 1 receptors for lordosis of rats and hamsters.
Lordosis
Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.
Lordosis
Progestin facilitation of lordosis in rodents involves adenylyl cyclase activity in the ventral tegmental area.
Lordosis
Roles of second-messenger systems and neuronal activity in the regulation of lordosis by neurotransmitters, neuropeptides, and estrogen: a review.
Lordosis
Two thalidomide analogs induce persistent estrous behavior and inhibit uterus contractility in rats: The central role of cAMP.
Lung Diseases
Cyclic adenosine monophosphate in acute ischemic stroke: some to update, more to explore.
Lung Injury
Reversal of pulmonary capillary ischemia-reperfusion injury by rolipram, a cAMP phosphodiesterase inhibitor.
Lung Injury
The Pseudomonas aeruginosa exoenzyme Y impairs endothelial cell proliferation and vascular repair following lung injury.
Lung Neoplasms
Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro.
Lung Neoplasms
Independent down-regulation of insulin and calcitonin receptors on a human tumour cell line.
Lung Neoplasms
Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer.
Lung Neoplasms
PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner.
Lung Neoplasms
PACAP-27 tyrosine phosphorylates mitogen activated protein kinase and increases VEGF mRNAs in human lung cancer cells.
Lung Neoplasms
Pituitary adenylate cyclase activating peptide receptors regulate the growth of non-small cell lung cancer cells.
Lung Neoplasms
Pituitary adenylate cyclase activating polypeptide causes tyrosine phosphorylation on the EGF receptor in lung cancer cells.
Lung Neoplasms
Pituitary adenylate cyclase activating polypeptide receptors are present on small cell lung cancer cells.
Lung Neoplasms
Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line.
Lung Neoplasms
Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells.
Lung Neoplasms
PYK-2 is Tyrosine Phosphorylated after Activation of Pituitary Adenylate Cyclase Activating Polypeptide Receptors in Lung Cancer Cells.
Lung Neoplasms
The cAMP signaling system inhibits the repair of ?-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells.
Lung Neoplasms
The G Protein-Coupled Receptor PAC1 Regulates Transactivation of the Receptor Tyrosine Kinase HER3.
Lung Neoplasms
VIP and PACAP receptors coupled to adenylyl cyclase in human lung cancer: a study in biopsy specimens.
Lymphatic Metastasis
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Lymphocytic Choriomeningitis
Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus.
Lymphocytic Choriomeningitis
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying multiple copies of a viral CD8(+) T-cell epitope.
Lymphocytic Choriomeningitis
In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes.
Lymphoma
2'(3')-O-(N-methylanthraniloyl)-substituted GTP analogs: a novel class of potent competitive adenylyl cyclase inhibitors.
Lymphoma
3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.
Lymphoma
A monoclonal antibody against the rod outer segment guanyl nucleotide-binding protein, transducin, blocks the stimulatory and inhibitory G proteins of adenylate cyclase.
Lymphoma
A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase.
Lymphoma
A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells.
Lymphoma
Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs.
Lymphoma
Activated Gs alpha but not Gi alpha prevents the thermal inactivation of adenylyl cyclase in plasma membranes derived from S49 lymphoma cells.
Lymphoma
Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein.
Lymphoma
Activation of adenylate cyclase during swelling of S49 cells in hypotonic medium is not involved in subsequent volume regulation.
Lymphoma
Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.
Lymphoma
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Lymphoma
Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.
Lymphoma
Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc- variants are prevented by islet-activating protein.
Lymphoma
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
Lymphoma
Agonist regulation of beta-adrenergic receptor mRNA. Analysis in S49 mouse lymphoma mutants.
Lymphoma
Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.
Lymphoma
Beta-adrenergic activity of (+/-)-hydroxybenzylisoproterenol in isolated rat fat cells and hepatocytes.
Lymphoma
beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma.
Lymphoma
Cell cycle arrest by prostaglandin A1 at the G1/S phase interface with up-regulation of oncogenes in S-49 cyc- cells.
Lymphoma
Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.
Lymphoma
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Lymphoma
Clonal variation of adenylyl cyclase activity in a rat tumor cell line caused by change in G protein-catalytic unit interaction.
Lymphoma
Cross-regulation between G-protein-mediated pathways. Stimulation of adenylyl cyclase increases expression of the inhibitory G-protein, Gi alpha 2.
Lymphoma
Cytosol activator protein from rat reticulocytes requires the stimulatory guanine nucleotide-binding protein for its actions on adenylate cyclase.
Lymphoma
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
Lymphoma
Desensitization and recovery of prostaglandin-stimulated adenylate cyclase activity in a murine virus-induced T lymphoma cell line BL/VL3.
Lymphoma
Desensitization of the beta-adrenergic receptor of the S49 murine lymphoma cell: mechanism of receptor loss and recovery.
Lymphoma
Differences in the forskolin activation of adenylate cyclases in wild-type and variant lymphoma cells.
Lymphoma
Differential effects of fluoride on adenylate cyclase activity and guanine nucleotide regulation of agonist high-affinity receptor binding.
Lymphoma
Direct evidence for the role of the coupling proteins in forskolin activation of adenylate cyclase.
Lymphoma
Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.
Lymphoma
Divergent regulation of beta 2-adrenoceptors and adenylate cyclase in the Cyc- mouse T lymphoma cell line TL2-9.
Lymphoma
Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction.
Lymphoma
Effects of ethanol in vitro on the beta adrenergic receptor-coupled adenylate cyclase system.
Lymphoma
Effects of N-ethylmaleimide on gonadotropin and beta-adrenergic receptor function coupled to rabbit luteal adenylyl cyclase.
Lymphoma
Enhancement of adenylate cyclase activity in S49 lymphoma cell membranes by the toxin thionin from Pyrularia pubera.
Lymphoma
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction.
Lymphoma
Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Withdrawal of GTP-dependent inhibition.
Lymphoma
Epinephrine desensitization of adenylate cyclase from cyc- and S49 cultured lymphoma cells.
Lymphoma
Evidence for a rabbit luteal ADP-ribosyltransferase activity which appears to be capable of activating adenylyl cyclase.
Lymphoma
Evidence for the role of epinephrine binding frequency in activation of adenylate cyclase.
Lymphoma
Expression of genes for metabolism of cyclic adenosine 3':5'-monophosphate in somatic cells. beta-Adrenergic and PGE1 receptors in parental and hybrid cells.
Lymphoma
Fat cell beta-adrenergic receptor in the hypothyroid rat. Impaired interaction with the stimulatory regulatory component of adenylate cyclase.
Lymphoma
Growth and protein phosphorylation in the Nb2 lymphoma: effect of prolactin, cAMP, and agents that activate adenylate cyclase.
Lymphoma
Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase.
Lymphoma
Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes. Regulation of both Ns and Ni.
Lymphoma
Homologous desensitization of beta-adrenergic receptor coupled adenylate cyclase. Resensitization by polyethylene glycol treatment.
Lymphoma
Hormone inhibition of adenylyl cyclase. Differences in the mechanisms for inhibition by hormones and G protein beta gamma.
Lymphoma
Hormone receptor modulates the regulatory component of adenylyl cyclase by reducing its requirement for Mg2+ and enhancing its extent of activation by guanine nucleotides.
Lymphoma
Human chorionic gonadotropin-induced heterologous desensitization of adenylyl cyclase from highly luteinized rat ovaries: attenuation of regulatory N component activity.
Lymphoma
Human chorionic gonadotropin-induced heterologous desensitization of rabbit luteal adenylyl cyclase is associated with altered receptor and G-protein function.
Lymphoma
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.
Lymphoma
Identification of a Gs activator region of the beta 2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation.
Lymphoma
Identification of the lesion in the stimulatory GTP-binding protein of the uncoupled S49 lymphoma.
Lymphoma
Inhibition of hormonally regulated adenylate cyclase by the beta gamma subunit of transducin.
Lymphoma
Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
Lymphoma
Interactions between cyclic AMP- and phorbol ester-dependent phosphorylation systems in S49 mouse lymphoma cells.
Lymphoma
Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown.
Lymphoma
Ischemic preconditioning is associated with a delay in ischemia-induced reduction of beta-adrenergic signal transduction in rabbit hearts.
Lymphoma
Isolation and characterization of S49 lymphoma cells deficient in beta-adrenergic receptors: relation of receptor number to activation of adenylate cyclase.
Lymphoma
Lowered responsiveness of the catalyst of adenylyl cyclase to stimulation by GS in heterologous desensitization: a role for adenosine 3',5'-monophosphate-dependent phosphorylation.
Lymphoma
Magnesium but not calcium accumulation is inhibited by beta-adrenergic stimulation in S49 lymphoma cells.
Lymphoma
Manganous chloride stimulation of adenylate cyclase responsiveness in ocular ciliary process membranes.
Lymphoma
Mechanism of action of glycopeptide hormones and cholera toxin: what is the role of ADP-ribosylation?
Lymphoma
Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site.
Lymphoma
Mechanisms of downregulation of beta-adrenergic receptors: perspective on the role of beta-adrenergic receptors in congestive heart failure.
Lymphoma
Membrane association of soluble protein activators of rat liver adenylate cyclase. Evidence for distinctness from the guanine nucleotide-binding stimulating protein (Ns).
Lymphoma
Modulation of catecholamine activation of adenylate cyclase by the number of active beta-adrenergic receptors: theoretical considerations on the role of receptor diffusion in the cell membrane.
Lymphoma
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.
Lymphoma
Multiple effects of phorbol esters on hormone-sensitive adenylate cyclase activity in S49 lymphoma cells.
Lymphoma
Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C.
Lymphoma
Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase.
Lymphoma
Naturally soluble component(s) that confer(s) guanine nucleotide and fluoride sensitivity to adenylate cyclase.
Lymphoma
Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.
Lymphoma
Occurrence of a hormone-sensitive inhibitory coupling component of the adenylate cyclase in S49 lymphoma cyc- variants.
Lymphoma
Occurrence of an inhibitory guanine nucleotide-binding regulatory component of the adenylate cyclase system in cyc- variants of S49 lymphoma cells.
Lymphoma
Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells.
Lymphoma
Overexpression of G(s)alpha in NG108-15, neuroblastomaXglioma cells: effects on receptor regulation of the stimulatory adenylyl cyclase cascade.
Lymphoma
Phorbol ester treatment impairs hormone- but not stable GTP analog-induced inhibition of adenylate cyclase.
Lymphoma
Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells.
Lymphoma
Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells.
Lymphoma
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase.
Lymphoma
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Lymphoma
Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.
Lymphoma
Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.
Lymphoma
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.
Lymphoma
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
Lymphoma
Recovery of VIP/helodermin- and prostaglandin E1-stimulated adenylate cyclase activities in desensitized SUP-T1 human lymphoblasts.
Lymphoma
Regulation of the catalytic component of adenylate cyclase. Potentiative interaction of stimulatory ligands and 2',5'-dideoxyadenosine.
Lymphoma
Relationship between alcohol consumption and the activity of GTP-binding regulatory proteins in human erythrocyte membranes.
Lymphoma
Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors.
Lymphoma
Resolution of some components of adenylate cyclase necessary for catalytic activity.
Lymphoma
Role of protein synthesis on ethanol regulation of adenylyl cyclase activity in wild-type S49 murine lymphoma cells.
Lymphoma
S49 lymphoma wild type and variant clones contain normal calcium dependent regulator.
Lymphoma
Selective effects of organic mercurials on the GTP-regulatory proteins of adenylate cyclase systems.
Lymphoma
Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha.
Lymphoma
Serum-stimulated cyclic-AMP production in S49 lymphoma cells grown in serum-free medium.
Lymphoma
Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.
Lymphoma
Somatostatin-induced stimulation of a high-affinity GTPase in membranes of S49 lymphoma cyc- and H21a variants.
Lymphoma
Specific muscarinic-cholinergic desensitization in the neuroblastoma-glioma hybrid NG108-15.
Lymphoma
Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase.
Lymphoma
Temperature-dependent changes in binding to beta-adrenergic receptors of intact S49 lymphoma cells. Implications for the state of the receptor that activates adenylate cyclase under physiological conditions.
Lymphoma
The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.
Lymphoma
The guanine nucleotide-binding regulatory component of adenylate cyclase in human erythrocytes.
Lymphoma
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes.
Lymphoma
The inverse relationship between drug affinity and effectiveness: prediction under rate theory, paradox under occupancy theory.
Lymphoma
The regulatory component of adenylate cyclase from uncoupled S49 lymphoma cells differs in charge from the wild type protein.
Lymphoma
The regulatory component of adenylate cyclase. Purification and properties of the turkey erythrocyte protein.
Lymphoma
Three adenylate cyclase phenotypes in S49 lymphoma cells produced by mutations of one gene.
Lymphoma
Transfer of functional opiate receptors from membranes to recipient cells by polyethylene glycol-induced fusion.
Lymphoma
Tumorigenicity of the cyc- variant of the S49 murine lymphoma deficient in the Gs-alpha subunit of adenylate cyclase.
Lymphoma
Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride.
Lymphoma
Variable stimulation of adenylate cyclase activity by vasoactive intestinal-like peptides and beta-adrenergic agonists in murine T cell lymphomas of immature, helper, and cytotoxic types.
Lymphoma, B-Cell
Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer.
Lymphoma, T-Cell
Properties of vasoactive-intestinal-peptide receptors and beta-adrenoceptors in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3.
Magnesium Deficiency
Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency.
Malaria
Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins.
Malaria
Complete protection against P. berghei malaria upon heterologous prime/boost immunization against circumsporozoite protein employing Salmonella type III secretion system and Bordetella adenylate cyclase toxoid.
Malaria
Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
Malaria
Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-Lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria.
Malaria
Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum.
Malnutrition
Activity of cAMP-dependent protein kinase is reduced in protein-energy malnourished rats.
Malnutrition
Adenylyl cyclase deficient cr-1 (Crisp) mutant of Neurospora crassa: cyclic AMP-dependent nutritional deficiencies.
Malnutrition
Effect of undernutrition on GMP-PNP binding and adenylate cyclase activity from rat brain.
Malnutrition
Effects of malnutrition on rat myocardial beta-adrenergic and muscarinic receptors.
Malnutrition
Effects of undernutrition during suckling and early post-weaning on the inhibition by met-enkephalin of striatal adenylate cyclase activity in adult rats.
Malnutrition
Stimulation of intestinal adenylate cyclase by cholera toxin in malnourished rats.
Mania
Dysbalance of neuronal second messenger function in the aetiology of affective disorders: a pathophysiological concept hypothesising defects beyond first messenger receptors.
Mania
Mechanisms of action of anticonvulsants in affective disorders: comparisons with lithium.
Mastocytoma
Altered binding properties of beta-adrenergic receptors and lack of coupling to adenylate cyclase in P815 mastocytoma cells.
Mastocytoma
Effect of adenosine 3',5'-monophosphate on growth and several functions of cultured mastocytoma P-815 cells.
Mastocytoma
Identification of a prostacyclin receptor coupled to the adenylate cyclase system via a stimulatory GTP-binding protein in mouse mastocytoma P-815 cells.
Mastocytoma
Identification of prostaglandin E receptor 'EP2' cloned from mastocytoma cells EP4 subtype.
Mastocytoma
Prostacyclin (PGI) receptor binding and cyclic AMP synthesis activities of PGI1 analogues, SM-10906 and its methyl ester, SM-10902, in mastocytoma P-815 cells.
Mastocytoma
TEI-9063, a stable and highly specific prostacyclin analogue for the prostacyclin receptor in mastocytoma P-815 cells.
Mastocytoma
[Cooperation of two subtypes of PGE2 receptor, Gi coupled EP3 and Gs coupled EP2 or EP4 subtype]
Measles
Effect of antibody-induced modulation of measles (SSPE) virus membrane proteins on beta-adrenergic receptor-mediated adenylate cyclase activity.
Measles
Measles virus modulates human T-cell somatostatin receptors and their coupling to adenylyl cyclase.
Medulloblastoma
Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA.
Medulloblastoma
Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.
Medulloblastoma
Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.
Melanoma
4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity.
Melanoma
A synthetic analog of the calmodulin-binding domain of myosin light chain kinase inhibits melanotropin receptor function and activation of adenylate cyclase.
Melanoma
Activation of ?2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells.
Melanoma
Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata).
Melanoma
Adenylate cyclase activity in homogenates of human melanoma cells. Effect of alpha-MSH and isoprenaline.
Melanoma
Alpha melanocyte stimulating hormone (alpha MSH) stimulates normal human melanocyte growth by binding to high-affinity receptors.
Melanoma
Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells.
Melanoma
Antagonist and agonist activities of the mouse agouti protein fragment (91-131) at the melanocortin-1 receptor.
Melanoma
Beta-carotene induces morphological differentiation and decreases adenylate cyclase activity in melanoma cells in culture.
Melanoma
Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties.
Melanoma
Comparative biological activities of potent active-site analogues of alpha-melanotropin. Effect of tyrosine substitution at position-4.
Melanoma
Decreased adenylate cyclase activation by helodermin and PGE1 in the lectin-resistant variant Wa4 of the mouse melanoma cell line B16.
Melanoma
Dual regulation of beta-melanotropin receptor function and adenylate cyclase by calcium and guanosine nucleotides in the M2R melanoma cell line.
Melanoma
Effect of vitamin E and indomethacin treatment on adenylate cyclase activity, PGE2 and cAMP levels in murine melanoma cells.
Melanoma
Effects of latanoprost on tyrosinase activity and mitotic index of cultured melanoma lines.
Melanoma
Effects of tumor promoters on adenylate cyclase activity in melanoma cells in culture.
Melanoma
EPAC-RAP1 Axis-mediated Switch in the Response of Primary and Metastatic Melanoma to cyclic AMP.
Melanoma
Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones.
Melanoma
Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells.
Melanoma
Gangliosides GD1b, GT1b, and GQ1b suppress the growth of human melanoma by inhibiting interleukin-8 production: the inhibition of adenylate cyclase.
Melanoma
Hormonal control of melanocytes: MSH-sensitive adenyl cyclase in the Cloudman melanoma.
Melanoma
Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2.
Melanoma
Inhibition by melittin and fluphenazine of melanotropin receptor function and adenylate cyclase in M2R melanoma cell membranes.
Melanoma
MicroRNA-23a-3p Inhibits Mucosal Melanoma Growth and Progression through Targeting Adenylate Cyclase 1 and Attenuating cAMP and MAPK Pathways.
Melanoma
MSH stimulates adenylate cyclase and tyrosinase in cultivated melanoma cells in the presence of cytochalasin B.
Melanoma
Multi-facet expressions of adenylate cyclase isoforms in B16-F10 melanoma cells differentiated by forskolin treatment.
Melanoma
Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
Melanoma
PHrmonal specificity of the melanotropin-sensitive adenylate cyclase of mouse melanoma and effect of cyclic AMP on the tyrosinase activity of mouse melanoma cells, in vitro.
Melanoma
Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Melanoma
Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, D-Phe7]-substituted alpha-melanotropins.
Melanoma
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes.
Melanoma
Regulation of adenylate cyclase by beta-melanotropin in the M2R melanoma cell line.
Melanoma
Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins.
Melanoma
Stimulation of the adenylate cyclase of A B16 melanoma cell line by pro-opiocortin-related peptides--a structure-activity study.
Melanoma
Synthesis and structure-function studies of melanocyte stimulating hormone analogues modified in the 2 and 4(7) positions: comparison of activities on frog skin melanophores and melanoma adenylate cyclase.
Melanoma
The role of adenylate cyclase, cAMP and PGE2 in the in vitro growth regulation of murine melanoma cells by vitamin E.
Melanoma
[half-Cys4,half-Cys10]-alpha-Melanocyte-stimulating hormone: a cyclic alpha-melanotropin exhibiting superagonist biological activity.
Melanoma
[Regulatory role of DOPA and components of the cyclic adenosine-3',5'-monophosphate system]
Melanoma, Experimental
Acetoside inhibits alpha-MSH-induced melanin production in B16 melanoma cells by inactivation of adenyl cyclase.
Melanoma, Experimental
Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties.
Melanoma, Experimental
Calmodulin activation of adenylate cyclase in the mouse B16 melanoma.
Melanoma, Experimental
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
Melanoma, Experimental
Regulation of adenylate cyclase by beta-melanotropin in the M2R melanoma cell line.
Melanoma, Experimental
Stimulation of the adenylate cyclase of A B16 melanoma cell line by pro-opiocortin-related peptides--a structure-activity study.
Melanoma, Experimental
Whitening activity of luteolin related to the inhibition of cAMP pathway in alpha-MSH-stimulated B16 melanoma cells.
Memory Disorders
Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway.
Memory Disorders
Distribution of 5-HT(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study.
Memory Disorders
Domoic acid-induced neurodegeneration resulting in memory loss is mediated by Ca2+ overload and inhibition of Ca2+ + calmodulin-stimulated adenylate cyclase in rat brain (review).
Meniere Disease
Adenylate cyclase modulation of ion permeability in the guinea pig cochlea: a possible mechanism for the formation of endolymphatic hydrops.
Meningioma
Relationship between cAMP induced inhibition of human meningioma cell proliferation and autocrine secretion of interleukin-6.
Meningioma
Somatostatin inhibits the activity of adenylate cyclase in cultured human meningioma cells and stimulates their growth.
Meningioma
Somatostatin receptors in human cancer: incidence, characteristics, functional correlates and clinical implications.
Mesothelioma, Malignant
Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro.
Metabolic Syndrome
Association analysis of genetic variants with metabolic syndrome components in the Moroccan population.
Metabolic Syndrome
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice.
Migraine Disorders
5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs.
Migraine Disorders
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model.
Migraine Disorders
Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38.
Migraine Disorders
Improvement of the closed cranial window model in rats by intracarotid infusion of signalling molecules implicated in migraine.
Migraine Disorders
No Change in Interictal PACAP Levels in Peripheral Blood in Women With Chronic Migraine.
Migraine Disorders
PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma.
Migraine Disorders
PACAP-38 and PACAP(6-38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor.
Migraine Disorders
Serum CGRP, VIP, and PACAP usefulness in migraine: a case-control study in chronic migraine patients in real clinical practice.
Migraine Disorders
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in the circulation after sumatriptan.
Mitral Valve Prolapse
Abnormal Gs function in mitral valve prolapse dysautonomia is not associated with abnormal alpha S cDNA sequence.
Mitral Valve Stenosis
Cardiac beta-adrenoceptors and adenylyl cyclase activity in human left ventricular hypertrophy due to pressure overload.
Mitral Valve Stenosis
Effects of the H2-receptor agonist impromidine in human myocardium from patients with heart failure due to mitral and aortic valve disease.
Mitral Valve Stenosis
[Beta-adrenergic receptivity and left ventricular hypertrophy caused by pressure overload in man]
Movement Disorders
A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea.
Movement Disorders
ADCY5-Related Dyskinesia: Improving Clinical Detection of an Evolving Disorder.
Movement Disorders
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Movement Disorders
Autosomal dominant familial dyskinesia and facial myokymia: single exome sequencing identifies a mutation in adenylyl cyclase 5.
Movement Disorders
Clinical exome sequencing in early-onset generalized dystonia and large-scale resequencing follow-up.
Movement Disorders
Deep brain stimulation reduces (nocturnal) dyskinetic exacerbations in patients with ADCY5 mutation: a case series.
Movement Disorders
Gain-of-function ADCY5 mutations in familial dyskinesia with facial myokymia.
Movement Disorders
Homozygous ADCY5 mutation causes early-onset movement disorder with severe intellectual disability.
Movement Disorders
Hyperphosphorylated Tau, Increased Adenylate Cyclase 5 (ADCY5) Immunoreactivity, but No Neuronal Loss in ADCY5-Dyskinesia.
Movement Disorders
Paroxysmal movement disorders - practical update on diagnosis and management.
Movement Disorders
PDE10A and ADCY5 mutations linked to molecular and microstructural basal ganglia pathology.
Movement Disorders
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
Movement Disorders
[ADCY5-associated dyskinesia in young children: a case report of a family and an updated review].
Multiple Sclerosis
The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis.
Multiple Sclerosis
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis.
Multiple System Atrophy
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Muscle Hypotonia
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Muscle Spasticity
The genetic etiology in cerebral palsy mimics: The results from a Greek tertiary care center.
Muscular Dystrophies
Adenyl cyclase and cyclic nucleotide phosphodiesterase activities in murine muscular dystrophy.
Muscular Dystrophies
Adenyl cyclase in the pectoral muscle of normal chickens and chickens with hereditary muscular dystrophy.
Muscular Dystrophies
[Creatine biosynthesis in mice with hereditary muscular dystrophy: possible defect in liver plasma membrane adenyl cyclase]
Muscular Dystrophy, Duchenne
Adenyl cyclase abnormality in Duchenne muscular dystrophy: muscle cells in culture.
Muscular Dystrophy, Duchenne
Adenylate cyclase and ATPase activities in red cell membranes of patients and genetic carriers of Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Erythrocyte membrane protein kinase and adenylate cyclase in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Protein kinase and adenylate cyclase of erythrocyte membrane from patients with Duchenne muscular dystrophy.
Myeloproliferative Disorders
Alpha 2-adrenoceptor coupling to adenylate cyclase in adrenaline insensitive human platelets.
Myocardial Infarction
A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion.
Myocardial Infarction
Adenylyl cyclase activity and function are decreased in rat cardiac fibroblasts after myocardial infarction.
Myocardial Infarction
Adenylyl cyclase regulation in heart failure due to myocardial infarction in rats.
Myocardial Infarction
Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion.
Myocardial Infarction
Decreased type VI adenylyl cyclase mRNA concentration and Mg(2+)-dependent adenylyl cyclase activities and unchanged type V adenylyl cyclase mRNA concentration and Mn(2+)-dependent adenylyl cyclase activities in the left ventricle of rats with myocardial infarction and longstanding heart failure.
Myocardial Infarction
Denervation supersensitivity of refractoriness in noninfarcted areas apical to transmural myocardial infarction.
Myocardial Infarction
Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failure.
Myocardial Infarction
Effects of beta-adrenergic blockade on papillary muscle function and the beta-adrenergic receptor system in noninfarcted myocardium in compensated ischemic left ventricular dysfunction.
Myocardial Infarction
Increased cardiac adenylyl cyclase expression is associated with increased survival after myocardial infarction.
Myocardial Infarction
Influence of cardiac dysfunction on fast sodium current regulation by Forskolin.
Myocardial Infarction
Pharmacological characterization of vasorelaxant effects of BMS-180448, a novel cardioselective ATP-sensitive potassium channel opener, in rat aorta.
Myocardial Infarction
Potent adenylate cyclase agonist forskolin restores myoprotective effects of ischemic preconditioning in rat hearts after myocardial infarction.
Myocardial Infarction
Regional beta-adrenergic receptors and adenylate cyclase activity after healing of myocardial infarction in cats.
Myocardial Infarction
Sensitization of the beta-adrenergic system in acute myocardial ischaemia by a protein kinase C-dependent mechanism.
Myocardial Infarction
Studies on adenyl cyclase system in myocardium (Part II). Adenyl cyclase system in myocardial infarction of dogs.
Myocardial Infarction
Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib.
Myocardial Infarction
[Systems for regulating the level of Ca2+, cyclic nucleotides, and reverse absorption of neurotransmitters in isolated nerve endings of the rat brain during development of myocardial infarct]
Myocardial Infarction
[The molecular cellular aspects in predicting the course of an acute myocardial infarct]
Myocardial Ischemia
Adrenergic receptors and sensitization of adenylyl cyclase in acute myocardial ischemia.
Myocardial Ischemia
Alpha 1-receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylyl cyclase system.
Myocardial Ischemia
Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion.
Myocardial Ischemia
Beta-receptors and adenylate cyclase: comparison of nonischemic, ischemic, and postmortem tissue.
Myocardial Ischemia
Dual sensitization of the adrenergic system in early myocardial ischemia: independent regulation of the beta-adrenergic receptors and the adenylyl cyclase.
Myocardial Ischemia
Expression of adenylyl cyclase and G-protein beta subunit in end-stage human heart failure.
Myocardial Ischemia
Expression, function, and regulation of E-type prostaglandin receptors (EP3) in the nonischemic and ischemic pig heart.
Myocardial Ischemia
Externalization of beta-adrenergic receptors promoted by myocardial ischemia.
Myocardial Ischemia
Impaired adenylate cyclase signaling in acute myocardial ischemia: Impact on effectiveness of P2Y12 receptor antagonists.
Myocardial Ischemia
Modification of beta-adrenoceptors and adenylyl cyclase in hearts perfused with hypochlorous acid.
Myocardial Ischemia
One hour of myocardial ischemia decreases the activity of the stimulatory guanine-nucleotide regulatory protein Gs.
Myocardial Ischemia
One hour of myocardial ischemia in conscious dogs increases beta-adrenergic receptors, but decreases adenylate cyclase activity.
Myocardial Ischemia
Preserved beta-adrenoceptor-mediated adenylyl cyclase activity despite receptor and postreceptor dysfunction in acute myocardial ischemia.
Myocardial Ischemia
Supersensitivity of the adenylyl cyclase system in acute myocardial ischemia: evaluation of three independent mechanisms.
Myocardial Ischemia
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
Myocardial Ischemia
The guanine nucleotide-binding regulatory proteins (G proteins) in myocardium with ischemia.
Myocardial Ischemia
[Adenyl cyclase activity in the thrombocytes of patients with ischemic heart disease]
Myocardial Ischemia
[Proceedings: Myocardial adenyl cyclase (5). Effects of propranolol on the ventricular fibrillation threshold in acute myocardial ischemia and the myocardial adenyl cyclase system]
Myocardial Stunning
Beta-adrenergic receptor signalling in stunned myocardium of conscious pigs.
Myocardial Stunning
Oxygen free radical injury and Gs mediated signal transduction in the stunned porcine myocardium.
Myocardial Stunning
The guanine nucleotide-binding regulatory proteins (G proteins) in myocardium with ischemia.
Myocarditis
Alterations in G-protein-regulated transmembrane signalling induced in murine myocardium by coxsackievirus B3 infection.
Myoclonus
ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients.
Myokymia
Facial twitches in ADCY5-associated disease - Myokymia or myoclonus? An electromyography study.
Myxedema
Inhibition of thyrotropin-induced adenosine 3'5'-monophosphate increase by immunoglobulins from patients with primary myxedema.
Myxedema
Inhibition of thyrotropin-stimulated adenylate cyclase activation and growth of rat thyroid cells, FRTL-5, by immunoglobulin G from patients with primary myxedema: comparison with activities of thyrotropin-binding inhibitor immunoglobulins.
Myxedema
Sera of patients with idiopathic myxedema contain IgG which block TSH-stimulated thyroid adenylate cyclase.
Myxedema
Thyroid autoantigens and their relevance in the pathogenesis of thyroid autoimmunity.
Nasal Polyps
Enzyme-ultracytochemical study of adenylate and guanylate cyclases in normal and pathologic human nasal mucosa.
Nasal Polyps
[Adenylate cyclase activity in human nasal polyps under conditions of stimulation of serotonin biosynthesis (in vitro)]
Neoplasm Metastasis
Carcinoma of the breast associated with hypercalcemia and the presence of parathyroid hormone-like substances in the tumor.
Neoplasm Metastasis
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
Neoplasm Metastasis
The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.
Neoplasm Metastasis
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Neoplasms
3',5'-cyclic adenosine monophosphate-dependent transcription of the CYP11A (cholesterol side chain cleavage cytochrome P450) gene involves a DNA response element containing a putative binding site for transcription factor Sp1.
Neoplasms
A 68 000 dalton protein genetically associated with corticotropin-sensitive adenylate cyclase activity. Purification and preliminary characterization using a specific antiserum.
Neoplasms
A mu-opiate receptor in 7315c tumor tissue mediates inhibition of immunoreactive prolactin release and adenylate cyclase activity.
Neoplasms
A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.
Neoplasms
A Pan-Cancer Analysis of the Prognostic Value and Expression of Adenylate Cyclase 7 (ADCY7) in Human Tumors.
Neoplasms
A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis.
Neoplasms
A role for cAMP-driven transactivation of EGFR in cancer aggressiveness - therapeutic implications.
Neoplasms
A study of cyclic nucleotide metabolism and the histology of rat liver during 3'-methyl-4-dimethylamino-azobenzene carcinogenesis. II. Cyclic AMP metabolism.
Neoplasms
A transplantable rat Leydig cell tumor--2. Adenylyl cyclase activation by prostaglandin E1, isoproterenol and glucagon.
Neoplasms
A transplantable rat Leydig cell tumor--3. Isoproterenol and prostaglandin E1 (PGE1) responsive adenylyl cyclase (AC). Regulatory effects of nucleotides and magnesium.
Neoplasms
A transplantable rat Leydig cell tumor--5. Cellular localization of beta-adrenergic and prostaglandin receptors and their effects on testosterone production.
Neoplasms
Absence of G(s)alpha gene mutations in childhood thyroid tumors after Chernobyl in contrast to sporadic adult thyroid neoplasia.
Neoplasms
Absence of somatostatin receptor type 2 A mutations and gip oncogene in pituitary somatotroph adenomas.
Neoplasms
ACTH and prostaglandin receptors in human adrenocortical tumors. Apparent modification of a specific component of the ACTH-binding site.
Neoplasms
Activated 3',5'-cyclic AMP-dependent protein kinase is sufficient to induce neuroendocrine-like differentiation of the LNCaP prostate tumor cell line.
Neoplasms
Activation of steroidogenesis and adenylate cyclase by adenosine in adrenal and Leydig tumor cells.
Neoplasms
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.
Neoplasms
Activity and hormone responsiveness of adenyl cyclase during induction of tumors in rat liver with 3'-methyl-4-dimethylaminoazobenzene.
Neoplasms
Adenosine potentiates lutropin-stimulated cyclic AMP production and inhibits lutropin-induced desensitization of adenylate cyclase in rat Leydig tumour cells.
Neoplasms
Adenylate cyclase 7 regulated by miR-192 promotes ATRA-induced differentiation of acute promyelocytic leukemia cells.
Neoplasms
Adenylate cyclase activity and steroidogenesis in phenotypic revertants of an ACTH-insensitive adrenal tumour cell line.
Neoplasms
Adenylate cyclase activity in adrenocorticotropic hormone-sensitive and mutant adrenocortical tumor cell lines.
Neoplasms
Adenylate cyclase activity in Y1 mouse adrenocortical tumor cells: some properties of the enzyme associated with purified plasma membrane fractions.
Neoplasms
Adenylate cyclase in human ovarian cancers: sensitivity to gonadotropins and nonhormonal activators.
Neoplasms
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
Neoplasms
Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.
Neoplasms
Adenylyl cyclase from a prolactin producing tumor cell: the effect of phenothiazines.
Neoplasms
Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.
Neoplasms
Agonist-induced desensitization of adenylyl cyclase in Y1 adrenocortical tumor cells.
Neoplasms
Alteration in the transmission of TSH-message to thyroid target in a transplantable rat thyroid tumor.
Neoplasms
Alterations in guanine nucleotide regulatory protein expression and activity in human hepatocellular carcinoma.
Neoplasms
Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line.
Neoplasms
Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas.
Neoplasms
Altered subcellular distribution of protein kinase C (a phorbol ester receptor). Possible role in tumor promotion and the regulation of cell growth: relationship to changes in adenylate cyclase activity.
Neoplasms
Amplification of the transketolase gene in desensitization-resistant mutant Y1 mouse adrenocortical tumor cells.
Neoplasms
Analysis of the proliferative response to lysophosphatidic acid in primary cultures of mammary epithelium: differences between normal and tumor cells.
Neoplasms
Anti-microtubular agents as inhibitors of desensitization to catecholamine stimulation of adenylate cyclase in Ehrlich ascites tumor cells.
Neoplasms
Antibodies against human chorionic gonadotropin convert the deglycosylated hormone from an antagonist to an agonist.
Neoplasms
Antibody binding to the beta-subunit of deglycosylated chorionic gonadotropin converts the antagonist to an agonist.
Neoplasms
Arrest of mammary tumor growth in vivo by L-arginine: stimulation of NAD-dependent activation of adenylate cyclase.
Neoplasms
Association of a 68,000-dalton protein with adrenocorticotropin-sensitive adenylate cyclase activity in Y1 adrenocortical tumor cells.
Neoplasms
Association of increased cyclic adenosine 3':5'-monophosphate content in cultured human breast cancer cells and release of hydrolytic enzymes and bone-resorbing activity.
Neoplasms
beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma.
Neoplasms
Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma.
Neoplasms
Beta-adrenergic signalling in neoplastic lung type 2 cells: glucocorticoid-dependent and -independent defects.
Neoplasms
Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells.
Neoplasms
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Neoplasms
Biochemical properties of the agonist-induced desensitization of the follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin-responsive adenylyl cyclase in cells expressing the recombinant gonadotropin receptors.
Neoplasms
Biochemical regulation of adenylate cyclase in murine melanoma clones with different metastatic properties.
Neoplasms
Bone and kidney adenylate cyclase-stimulating activity produced by a hypercalcemic canine adenocarcinoma line (CAC-8) maintained in nude mice.
Neoplasms
Calcitonin gene-related peptide (CGRP) acts independently of calcitonin on cyclic AMP formation in clonal osteogenic sarcoma cells (UMR 106-01).
Neoplasms
Calcitonin-responsive adenylate cyclase in a calcitonin-producing human cancer cell line.
Neoplasms
Catecholamine-induced stimulation of adenylate cyclase in parallel with a change in tubulin assembly in Ehrlich ascites tumor cells.
Neoplasms
Cationized serum albumin enhances basal and stimulated adenylate cyclase activity in canine renal membranes.
Neoplasms
Cerebral tumours induced by ENU; changes of adenylate cyclase activity in the tumour latency time.
Neoplasms
Changes in the cellular phenotype and extracellular matrix during progression of estrogen-induced mesenchymal kidney tumors in Syrian hamsters.
Neoplasms
Characteristics of an adenylate cyclase coupled beta 2-adrenergic receptor in a smooth muscle tumor cell line.
Neoplasms
Characterization of beta-adrenergic receptor linked to adenylate cyclase in a human cancer cell line (COLO 16).
Neoplasms
Characterization of the homologous and heterologous desensitization of rat Leydig-tumour-cell adenylate cyclase.
Neoplasms
Choleragen stimulates steroidogenesis and adenylate cyclase in cells lacking functional hormone receptors.
Neoplasms
Clinical implications of genetic defects in G proteins: oncogenic mutations in G alpha s as the molecular basis for the McCune-Albright syndrome.
Neoplasms
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.
Neoplasms
Clonal variation in adrenocorticotropin-induced desensitization of adenylate cyclase in Y1 adrenocortical tumor cells. Association with a 68,000-dalton protein.
Neoplasms
Clonal variation of adenylyl cyclase activity in a rat tumor cell line caused by change in G protein-catalytic unit interaction.
Neoplasms
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
Neoplasms
Co-purification of bone resorbing activity and adenylate cyclase stimulating activity from human tumours associated with the humoral hypercalcaemia of malignancy.
Neoplasms
Co-purification of calcium transport-stimulating and DNA synthesis-stimulating agents with parathormone-like activity isolated from the hypercalcaemic strain of the Walker 256 tumour.
Neoplasms
Comparative adenylate cyclase activities in homogenate and plasma membrane fractions of Morris hepatoma 5123tc (h).
Neoplasms
Comparison between vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide levels in neuroblastoma tumour tissues.
Neoplasms
Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme.
Neoplasms
Concurrent changes in growth-related biochemical parameters during regression of hormone-dependent rat mammary tumors.
Neoplasms
Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.
Neoplasms
Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells.
Neoplasms
Cyclic AMP-binding proteins: inverse relationship with estrogen-receptors in hormone-dependent mammary tumor regression.
Neoplasms
Cyclic nucleotide metabolism in differentiated and undifferentiated epithelial thyroid cells in culture.
Neoplasms
Cytochemical localization of adenyl cyclase in isoproterenol stimulated hepatoma ascites cells.
Neoplasms
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes.
Neoplasms
Decreased adenylyl cyclase and cAMP-dependent protein kinase activities inhibit the cytotoxic function of human natural killer cells.
Neoplasms
Decreased stathmin expression does not affect the actions of human choriogonadotropin or epidermal growth factor in Leydig tumor cells.
Neoplasms
Development of hyperlipidemia associated with increased lipolytic response of isolated adipose tissue cells following prolonged stimulation by an ectopic pituitary tumor.
Neoplasms
Diazepam inhibits forskolin-stimulated adenylyl cyclase activity in human tumour cells.
Neoplasms
Difference between magnesium and manganese ions in modification of effect of catecholamine on adenylate cyclase system in Ehrlich ascites tumor cells.
Neoplasms
Differences in adenylate cyclase activities in murine normal cells and bladder tumor cells in tissue culture.
Neoplasms
Different effects of selenium on cyclic AMP metabolism in hepatoma cells and normal liver cells.
Neoplasms
Differential activation of the 21-base-pair enhancer element of human T-cell leukemia virus type I by its own trans-activator and cyclic AMP.
Neoplasms
Differential cyclic AMP responses to calcitonin among human ovarian carcinoma cell lines: a calcitonin-responsive line derived from a rare tumor type.
Neoplasms
Differential effect of intestinal neuropeptides on invasion and migration of colon carcinoma cells in vitro.
Neoplasms
Differential transduction of dopamine signal in different subtypes of human growth hormone-secreting adenomas.
Neoplasms
Diminished binding of thyroid-stimulating hormone in a transplantable rat thyroid tumor as a possible cause of hormone unresponsiveness.
Neoplasms
Divergent effects of phenothiazines on Leydig tumor cell steroidogenesis and adenylate cyclase activity.
Neoplasms
Dopamine decreases 7315a tumor cell prolactin release induced by calcium mobilization.
Neoplasms
Dual effect of pituitary adenylate cyclase activating polypeptide on prostate tumor LNCaP cells: short- and long-term exposure affect proliferation and neuroendocrine differentiation.
Neoplasms
Ectopic beta-adrenergic receptor binding sites. possible molecular basis of aberrant catecholamine responsiveness of an adrenocortical tumor adenylate cyclase.
Neoplasms
Ectopic beta-adrenergic receptors coupled to adenylate cyclase in human adrenocortical carcinomas.
Neoplasms
Effect of prostaglandins on adenylate cyclase activities in membranes from liver and transplantable hepatomas.
Neoplasms
Effect of somatostatin on growth hormone release by MtT-F4 rat pituitary tumor in vitro.
Neoplasms
Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin.
Neoplasms
Effects of catecholamines and monovalent cations on adenylate cyclase activity in cultured glial tumor cells.
Neoplasms
Effects of forskolin on Kupffer cell production of interleukin-10 and tumor necrosis factor alpha differ from those of endogenous adenylyl cyclase activators: possible role for adenylyl cyclase 9.
Neoplasms
Effects of ketoconazole on progesterone and cAMP production in MA-10 mouse Leydig tumor cells.
Neoplasms
Effects of the tumor promoter, phorbol 12-myristate, 13-acetate, on the epidermal adenylate cyclase system: evidence for adenylate cyclase-regulation by protein kinase C.
Neoplasms
Effects of tumor promoters on adenylate cyclase activity in melanoma cells in culture.
Neoplasms
EGFR may couple moderate alcohol consumption to increased breast cancer risk.
Neoplasms
Elevation of intracellular cyclic adenosine 3',5'-monophosphate levels in macrophages activated with lipopolysaccharide for tumor cell killing.
Neoplasms
Endotoxic lipopolysaccharides stimulate steroidogenesis and adenylate cyclase in adrenal tumor cells.
Neoplasms
Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.
Neoplasms
EPAC-RAP1 Axis-mediated Switch in the Response of Primary and Metastatic Melanoma to cyclic AMP.
Neoplasms
Epidermal growth factor desensitizes the gonadotropin-responsive adenylyl cyclase in membranes isolated from MA-10 Leydig tumor cells and luteinized rat ovaries.
Neoplasms
Epigenetic identification of ADCY4 as a biomarker for breast cancer: an integrated analysis of adenylate cyclases.
Neoplasms
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein.
Neoplasms
Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system.
Neoplasms
Evaluation of Cytotoxicity and Hypoxic Effect of Nitroimidazole Embedded Nanoparticles.
Neoplasms
Evaluation of receptor function in ACTH-responsive and ACTH-insensitive adrenal tumor cells.
Neoplasms
Experimental metastasis correlates with cyclic AMP accumulation in B16 melanoma clones.
Neoplasms
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Neoplasms
Expression of pituitary adenylate cyclase activating polypeptide (PACAP) receptors in human glial cell tumors.
Neoplasms
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
Neoplasms
Expression of vasoactive intestinal peptide and functional VIP receptors in human prostate cancer: antagonistic action of a growth-hormone-releasing hormone analog.
Neoplasms
Extracellular cAMP formation from host cell ATP by Bordetella pertussis adenylate cyclase.
Neoplasms
Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells.
Neoplasms
Failure of parathyroid hormone antagonists to inhibit in vitro bone resorbing activity produced by two animal models of the humoral hypercalcemia of malignancy.
Neoplasms
Forskolin and a tumor promoter are able to induce c-fos and c-myc expression in normal, but not in a v-ras-transformed rat thyroid cell line.
Neoplasms
Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.
Neoplasms
Forskolin-resistant Y1 mutants harbor defects associated with the guanyl nucleotide-binding regulatory protein, Gs.
Neoplasms
Functional receptors for VIP, GIP, glucagon-29 and -37 in the HGT-1 human gastric cancer cell line.
Neoplasms
GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation.
Neoplasms
GNAS1 (G?s) Gene T393C Polymorphism and Renal Cell Carcinoma Risk in a North Indian Population: A Case-Control Study.
Neoplasms
Gonadotropin-mediated desensitization in a murine Leydig tumor cell line does not alter the regulatory and catalytic components of adenylate cyclase.
Neoplasms
Gonadotropin-releasing hormone signaling pathways in an experimental ovarian tumor.
Neoplasms
Guanine nucleotide mediated desensitization of adenylate cyclase in cell free preparations from a Leydig cell tumour.
Neoplasms
Guanosine triphosphate-sensitive adenylate cyclase of adrenocorticotrophic hormone- and prostaglandin-resistant human adrenocortical tumors.
Neoplasms
Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway.
Neoplasms
Heterogeneous forms of thyroid-stimulating hormone in mouse thyrotropic tumor and serum: differences in receptor-binding and adenylate cyclase-stimulating activity.
Neoplasms
High throughput synthetic lethality screen reveals a tumorigenic role of adenylate cyclase in fumarate hydratase-deficient cancer cells.
Neoplasms
Higher TNF? responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression.
Neoplasms
Hormonal modulation of plasminogen activator: an approach to prediction of human breast tumor responsiveness.
Neoplasms
Hormonal regulation of adenylate cyclase activity in circulating lymphocytes and its interrelationship with hormone sensitivity of tumor tissue in colorectal cancer patients.
Neoplasms
Human pancreatic tumor growth hormone-releasing factor stimulates anterior pituitary adenylate cyclase activity, adenosine 3',5'-monophosphate accumulation, and growth hormone release in a calmodulin-dependent manner.
Neoplasms
Humoral hypercalcaemia of malignancy: report of two further patients with biochemical studies on tumour extracts.
Neoplasms
Hydrodynamic properties of the gonadotropin receptor from a murine Leydig tumor cell line are altered by desensitization.
Neoplasms
Identification of a Leydig tumor cell protein that is phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor.
Neoplasms
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Neoplasms
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy.
Neoplasms
In vitro synthesis of steroids by a feminising adrenocortical carcinoma: effect of prolactin and other protein hormones.
Neoplasms
Indications for selective coupling to phosphoinositide hydrolysis or to adenylate cyclase inhibition by endogenous muscarinic receptor subtypes M3 and M4 but not by M2 in tumor cell lines.
Neoplasms
Influence of lithium ions on epinephrine-stimulated adenylate cyclase activity in cultured glial tumor cells.
Neoplasms
Inhibition of cell migration via G protein-coupled receptors to opioid peptides and angiotensin.
Neoplasms
Inhibition of gonadotropin-responsive adenylate cyclase in MA-10 Leydig tumor cells by epidermal growth factor.
Neoplasms
Inhibition of hCG-stimulated steroidogenesis in cultured mouse Leydig tumor cells by bisphenol A and octylphenols.
Neoplasms
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.
Neoplasms
Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: rationale for their antimetastatic effects.
Neoplasms
Inhibitory guanine nucleotide binding protein in pig epidermis: regulation of epidermal adenylate cyclase.
Neoplasms
Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA.
Neoplasms
Isolation and characterization of plasma membranes containing LH sensitive adenylate cyclase from a Leydig cell tumour.
Neoplasms
Isolation of forskolin-resistant adrenal cells defective in the adenylate cyclase system.
Neoplasms
Lack of immunological analogy between the beta-subunits of cholera toxin and human choriogonadotropin.
Neoplasms
Leydig tumor cell protein phosphorylated in response to stimulation with choriogonadotropin or epidermal growth factor is identified as stathmin.
Neoplasms
Loss of prostaglandin E receptors during progression of rat mammary tumors from hormonal dependence to autonomy.
Neoplasms
Low temperature blocks the stimulatory effect of human chorionic gonadotropin on steroidogenic acute regulatory protein mRNA and testosterone production but not cyclic adenosine monophosphate in mouse Leydig tumor cells.
Neoplasms
Lymphocyte and macrophage adenyl cyclase activity in animals with enhanced cell-mediated resistance to infection and tumors.
Neoplasms
Mammosomatotroph adenoma causing gigantism in an 8-year old boy: a possible pathogenetic mechanism.
Neoplasms
Mechanism of action of glycopeptide hormones and cholera toxin: what is the role of ADP-ribosylation?
Neoplasms
Mechanisms of calcitonin induction of prolonged activation of adenylate cyclase in human cancer cells.
Neoplasms
Medroxyprogesterone acetate (MPA) stimulates adenylate cyclase activity in rat mammary tumours.
Neoplasms
Metabolic regulation and relationship of endogenous protein kinase activity and steroidogenesis in isolated adrenocortical carcinoma cells of the rat.
Neoplasms
Modification of the amounts of G proteins and of the activity of adenylyl cyclase in human benign thyroid tumours.
Neoplasms
Modulation of the beta-adrenergic receptor-coupled adenylate cyclase by chemical inducers of differentiation: effects on beta receptors and the inhibitory regulatory protein Gi.
Neoplasms
Molecular mechanisms of corticotropin-releasing factor stimulation of calcium mobilization and adrenocorticotropin release from anterior pituitary tumor cells.
Neoplasms
Multiple hormone receptors in the adenylate cyclase of human adrenocortical tumors.
Neoplasms
Naturally occurring forms of thyrotropin with low bioactivity and altered carbohydrate content act as competitive antagonists to more bioactive forms.
Neoplasms
PACAP action in nervous system development, regeneration, and neuroblastoma cell proliferation.
Neoplasms
PACAP38 and PACAP6-38 Exert Cytotoxic Activity Against Human Retinoblastoma Y79 Cells.
Neoplasms
Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia.
Neoplasms
Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
Neoplasms
Partial dopamine D2 receptor agonists antagonize prolactin-regulating D2 receptors in a transfected clonal cell line (GH4ZR7).
Neoplasms
Peculiarities of hormonal regulation of adenylate cyclase and lipid composition in colonic and rectal tumors.
Neoplasms
Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities.
Neoplasms
Pertussis toxin blocks somatostatin inhibition of calcium mobilization and reduces the affinity of somatostatin receptors for agonists.
Neoplasms
Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.
Neoplasms
Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes.
Neoplasms
Phorbol diesters promote beta-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes.
Neoplasms
Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line.
Neoplasms
Phorbol ester induces loss of VIP stimulation of adenylate cyclase and VIP-binding sites in HT29 cells.
Neoplasms
Phorbol esters do not influence the maturation and the beta-adrenergic responsiveness of differentiated adipose precursor cells, cultured in a charcoal-treated serum medium.
Neoplasms
Pituitary adenylate cyclase activating peptide and its receptors are expressed in human neuroblastomas.
Neoplasms
Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation.
Neoplasms
Pituitary adenylate cyclase-activating polypeptide directly stimulates LH and FSH secretion by human pituitary gonadotrophinomas.
Neoplasms
Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal polypeptide receptor subtypes are differently expressed in rat transplanted pituitary tumours (SMtTW) and in the normal gland.
Neoplasms
Platelet-derived growth factor and fibroblast growth factor differentially regulate interleukin 1beta- and cAMP-induced group II phospholipase A2 expression in rat renal mesangial cells.
Neoplasms
Positive cardiac inotropic effect of albumin infusion in rats with cirrhosis and ascites: Molecular mechanisms.
Neoplasms
Presence of ectopic beta-adrenergic receptors on human adrenocortical cortisol-producing adenomas.
Neoplasms
Presence of somatostatin receptors negatively coupled to adenylate cyclase in ectopic growth hormone-releasing hormone- and alpha-subunit-secreting tumors from acromegalic patients responsive to octreotide.
Neoplasms
Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara.
Neoplasms
Proceedings: Alterations in liver adenylate cyclase responsiveness during induction of tumours in rat liver with 3'-methyl-4-dimethylaminoazobenzene.
Neoplasms
Production of recombinant lethal factor of Bacillus anthracis in Bacillus subtilis.
Neoplasms
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
Neoplasms
Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line.
Neoplasms
Properties of AT1a and AT1b angiotensin receptors expressed in adrenocortical Y-1 cells.
Neoplasms
Protein kinase C activity can desensitize the gonadotropin-responsive adenylate cyclase in Leydig tumor cells. But hCG-induced desensitization does not involve protein kinase C activation.
Neoplasms
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Neoplasms
Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3',5'-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: evidence for crosstalk between transduction pathways.
Neoplasms
Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.
Neoplasms
Purification of peptides with parathyroid hormone-like bioactivity from human and rat malignancies associated with hypercalcemia.
Neoplasms
Pyrrolidine dithiocarbamate differentially affects cytokine- and cAMP-induced expression of group II phospholipase A2 in rat renal mesangial cells.
Neoplasms
Radiation induced osteogenic sarcoma in the rat as a model of hormone-responsive differentiated cancer.
Neoplasms
Rapid localization of parathyroid tumors by selective venous catheterization and parathyroid hormone bioassay.
Neoplasms
Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.
Neoplasms
Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes.
Neoplasms
Reduced Malignancy as a Mechanism for Longevity in Mice with Adenylyl Cyclase Type 5 (AC5) Disruption.
Neoplasms
Regulation of adenylate cyclase activity in GH1 cells by chlorpromazine and a heat-stable factor.
Neoplasms
Regulation of adenylate cyclase from glial tumor cells by calcium and a calcium-binding protein.
Neoplasms
Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.
Neoplasms
Regulation of adenylyl cyclase by noradrenaline and tumour necrosis factor alpha in rat cardiomyocytes.
Neoplasms
Regulation of cyclic adenosine 3',5'-monophosphate in relation to growth of dimethylbenz[a]anthracene-induced mammary tumors in rats.
Neoplasms
Regulation of growth hormone secretion and messenger ribonucleic acid accumulation in human somatotropinoma cells in vitro.
Neoplasms
Regulation of in vitro insulin release from a transplantable Syrian hamster insulinoma.
Neoplasms
Regulation of thyrotropin (TSH) release and production in monolayer cultures of transplantable TSH-producing mouse tumors.
Neoplasms
Relationship between protein kinase C and adenylyl cyclase activity in the regulation of growth hormone secretion by human pituitary somatotrophinomas.
Neoplasms
Resensitization of lutropin-desensitized tumour Leydig-cell adenylate cyclase with human erythrocyte membranes.
Neoplasms
Resistance to somatostatin (SRIH) analog therapy in acromegaly. Re-evaluation of the correlation between the SRIH receptor status of the pituitary tumor and the in vivo inhibition of GH secretion in response to SRIH analog.
Neoplasms
Role of cyclic AMP and protein kinase on the steroidogenic action of ACTH, prostaglandin E1 and dibutyryl cyclic AMP in normal adrenal cells and adrenal tumor cells from humans.
Neoplasms
Role of receptor binding in toxicity, immunogenicity, and adjuvanticity of Escherichia coli heat-labile enterotoxin.
Neoplasms
Similarities and differences in phorbol ester- and luteinizing-hormone-induced desensitization of rat tumour Leydig-cell adenylate cyclase.
Neoplasms
Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins.
Neoplasms
Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretions.
Neoplasms
Somatostatin receptors, adenylate cyclase activity, and growth hormone (GH) response to octreotide in GH-secreting adenomas.
Neoplasms
Striatal dopamine-stimulated adenylate cyclase activity reflects susceptibility of rats to 7,12-dimethylbenz[a]anthracene-induced mammary tumor development.
Neoplasms
Structure-guided cancer blockade between bioactive bursehernin and proteins: Molecular docking and molecular dynamics study.
Neoplasms
Studies on cyclic nucleotides in cancer. I. Adenylate guanylate cyclase and protein kinases in the prostatic sarcoma tissue.
Neoplasms
Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor.
Neoplasms
Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.
Neoplasms
Synergistic induction of interleukin 2 receptor (TAC) expression on YT cells by interleukin 1 or tumor necrosis factor alpha in combination with cAMP inducing agents.
Neoplasms
Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.
Neoplasms
Temperature effects on the modulation of adenylate cyclases from rat liver and Morris hepatomas.
Neoplasms
Tetraspanin family identified as the central genes detected in gastric cancer using bioinformatics analysis.
Neoplasms
The adenylate cyclase activator forskolin partially protects L929 cells against tumour necrosis factor-alpha-mediated cytotoxicity via a cAMP-independent mechanism.
Neoplasms
The biochemical mechanisms of the stimulating action of estradiol on the growth of mammary tumours.
Neoplasms
The content and metabolism of cyclic adenosine 3', 5'-monophosphate and cyclic guanosine 3', 5'-monophosphate in adenocarcinoma of the human colon.
Neoplasms
The effect of cardiac arrest on the blood-testis barrier to albumin, tumor necrosis factor-alpha, pituitary adenylate cyclase activating polypeptide, sucrose, and verapamil in the mouse.
Neoplasms
The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network.
Neoplasms
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
Neoplasms
The relation between cell proliferation and adenylate cyclase activity in grafts of 3-methylcholanthrene induced mouse uterine cervical tumors.
Neoplasms
The role of the adenosinergic pathway in immunosuppression mediated by human regulatory T cells (Treg).
Neoplasms
Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase carrying a cytotoxic T cell epitope.
Neoplasms
Thrombin- and histamine-induced signal transduction in human endothelial cells. Stimulation and agonist-dependent desensitization of protein phosphorylation.
Neoplasms
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Neoplasms
Thyrotropin (TSH) receptor and adenylate cyclase activity in human thyroid tumors: absence of high affinity receptor and loss of TSH responsiveness in undifferentiated thyroid carcinoma.
Neoplasms
Thyrotropin stimulation of the ADP-ribosyltransferase activity of bovine thyroid membranes.
Neoplasms
Tumor necrosis factor alpha stimulates adenylyl cyclase activity in human myometrial cells.
Neoplasms
Tumor necrosis factor alpha up-regulates Gi alpha and G beta proteins and adenylyl cyclase responsiveness in rat cardiomyocytes.
Neoplasms
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Neoplasms
Tumour promoter uncouples beta-adrenergic receptor from adenyl cyclase in mouse epidermis.
Neoplasms
Two species of adenylate cyclase-stimulating activity in a murine squamous carcinoma model of humoral hypercalcemia of malignancy.
Neoplasms
Use of a semi-automated, robotic radioimmunoassay to measure cAMP generated by activation of DP-, EP2-, and IP-prostaglandin receptors in human ocular and other cell types.
Neoplasms
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating peptide (PACAP) receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation.
Neoplasms
Vasoactive intestinal peptide (VIP) increases vascular endothelial growth factor (VEGF) expression and secretion in human breast cancer cells.
Neoplasms
Vasoactive intestinal peptide- and adrenocorticotropin-stimulated adenyl cyclase in cultured adrenal tumor cells: evidence for a specific vasoactive intestinal peptide receptor.
Neoplasms
Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer.
Neoplasms
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Neoplasms
Watery diarrhea syndrome in an adult with ganglioneuroma-pheochromocytoma: identification of vasoactive intestinal peptide, calcitonin, and catecholamines and assessment of their biologic activity.
Neoplasms
[Adenylate cyclase activity and cyclic nucleotide content in human adrenal tumors under Icenko-Cushing syndrome]
Neoplasms
[Adenylate cyclase complex, lipids and the regulation of the hormonal sensitivity of tumor tissue]
Neoplasms
[adenylate cyclase system in Ehrlich ascites tumor cells sensitive and resistant to 5-fluorouracil]
Neoplasms
[Age-related changes in adenylate cyclase activity, lipid composition and lipid peroxidation in rat intestinal mucosa: comparison with the frequency of spontaneous tumors]
Neoplasms
[Amplification of the heterologous response of adenylate cyclase in colonic tumors: relation to tissue lipid composition]
Neoplasms
[Biochemical differences in the tumor cells of 5-fluorouracil-sensitive and -resistant strains of Ehrlich ascitic carcinoma]
Neoplasms
[Cancerostatically active 6,6a,7,8,13,13a-hexahydro-1-benzopyrano[4,3-b]-1,5-benzodiazepine diastereoisomers (author's transl)]
Neoplasms
[Comparative study on activity of adenylate cyclase in normal human ovary with ovarian tumors]
Neoplasms
[Concentration and metabolism of cyclic AMP during the early stages of hepatoma 22a growth]
Neoplasms
[Concentration of cyclic nucleotides, activity of adenylate cyclase, 3',5'-AMP phosphodiesterase and guanylate cyclase in plasma membranes from liver and hepatomas of different degrees of malignancy]
Neoplasms
[Effect of hypolipidemic preparations on basal and stimulated adenylate cyclase activity in tumor cells]
Neoplasms
[Expression of proto-oncogenes myc and ras and hormonal regulation of adenylate cyclase in human colon tumor cells]
Neoplasms
[Participation of the adenyl cyclase system in estradiol-activated growth of tumors in rat mammary glands]
Neoplasms
[Proceedings: Experimental transplantable cancer and cyclic nucleotides. I. Adenyl cyclase activity and protein phosphorylating enzymes in transplantable prostatic cancer]
Neoplasms
[Some features of cyclic adenosine monophosphate metabolism in mouse liver and hepatoma 22]
Neoplasms
[Studies on the thyrotropin receptor and adenylate cyclase activity in various thyroid diseases: II. The properties of TSH receptor and adenylate cyclase in human thyroid tumors (author's transl)]
Neoplasms
[The assessment of the hormonal sensitivity of tumors of the large intestine in the adenylate cyclase test]
Neoplasms
[The effect of estradiol on the activity of cAMP-dependent protein kinase in cells of estradiol-dependent tumors of the rat mammary gland. The role of a thermally stable protein inhibitor of cAMP-dependent protein kinase]
Neoplasms
[The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine]
Neoplasms
[The role of protein kinase C in the adenylate cyclase activation by estradiol in the plasma membranes of estradiol-dependent tumors]
Nephrolithiasis
Erratum: Use of whole-exome sequencing to identify a novel ADCY10 mutation in a patient with nephrolithiasis.
Nephrolithiasis
Use of whole-exome sequencing to identify a novel ADCY10 mutation in a patient with nephrolithiasis.
Nephrosis
cAMP Signaling Prevents Podocyte Apoptosis via Activation of Protein Kinase A and Mitochondrial Fusion.
Nervous System Diseases
Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications.
Neuralgia
Adenylate cyclase inhibition attenuates neuropathic pain but lacks pre-emptive effects in rats.
Neuralgia
Analgesic effects of adenylyl cyclase inhibitor NB001 on bone cancer pain in a mouse model.
Neuralgia
Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states.
Neuralgia
Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.
Neuralgia
The 5-HT6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain.
Neuroblastoma
38-Amino acid form of pituitary adenylate cyclase activating peptide induces process outgrowth in human neuroblastoma cells.
Neuroblastoma
5'-Deoxy-5'-methylthioadenosine: a nucleoside which differentiates between adenosine receptor types.
Neuroblastoma
A neuroblastoma clone which has dopamine-sensitive adenylate cyclase but which lacks stereospecific binding sites for the neuroleptic [3H]spiperone.
Neuroblastoma
Activation of dopamine receptors does not affect phosphoinositide turnover in NCB-20 cells.
Neuroblastoma
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Neuroblastoma
Adenosine receptors linked to adenylate cyclase activity in human neuroblastoma cells: modulation during cell differentiation.
Neuroblastoma
Adenylate cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids.
Neuroblastoma
Adenylate cyclase from synchronized neuroblastoma cells: responsiveness to prostaglandin E1, adenosine, and dopamine during the cell cycle.
Neuroblastoma
Adenylyl cyclase in SH-SY5Y human neuroblastoma cells is regulated by intra- and extracellular calcium.
Neuroblastoma
Adenylyl cyclase supersensitivity in opioid-withdrawn NG108-15 hybrid cells requires Gs but is not mediated by the Gsalpha subunit.
Neuroblastoma
Agonist regulation of adenylate cyclase activity in neuroblastoma x glioma hybrid NG108-15 cells transfected to co-express adenylate cyclase type II and the beta 2-adrenoceptor. Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity.
Neuroblastoma
Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor.
Neuroblastoma
Agonist-induced desensitization of D1-dopamine receptors linked to adenylyl cyclase activity in cultured NS20Y neuroblastoma cells.
Neuroblastoma
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Neuroblastoma
Alpha 2-adrenergic receptors in neuroblastoma x glioma hybrid cells. Characterization with agonist and antagonist radioligands and relationship to adenylate cyclase.
Neuroblastoma
Alterations in the expression of G-proteins and regulation of adenylate cyclase in human neuroblastoma SH-SY5Y cells chronically exposed to low-efficacy mu-opioids.
Neuroblastoma
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Neuroblastoma
Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes.
Neuroblastoma
Attenuation of enkephalin activity in neuroblastoma X glioma NG108-15 hybrid cells by phospholipases.
Neuroblastoma
Attenuation of nociceptin/orphanin FQ-induced signaling by N-methyl-D-aspartate in neuronal cells.
Neuroblastoma
Beta-adrenoceptor, vasoactive intestinal polypeptide (VIP) and neuropeptide tyrosine (NPY) receptors functionally coupled to adenylate cyclase in the human neuroblastoma SK-N-MC cell line.
Neuroblastoma
Binding of aminoalkylindoles to noncannabinoid binding sites in NG108-15 cells.
Neuroblastoma
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Neuroblastoma
Biphasic regulation of adenylate cyclase by cholera toxin in neuroblastoma x glioma hybrid cells is due to the activation and subsequent loss of the alpha subunit of the stimulatory GTP binding protein (GS).
Neuroblastoma
Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells.
Neuroblastoma
Calmodulin inhibits entry of Bordetella pertussis adenylate cyclase into animal cells.
Neuroblastoma
cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: High cCMP and cUMP levels in astrocytes.
Neuroblastoma
Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes.
Neuroblastoma
Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes.
Neuroblastoma
Cannabinoid inhibition of adenylate cyclase: relative activity of constituents and metabolites of marihuana.
Neuroblastoma
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides.
Neuroblastoma
CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.
Neuroblastoma
Cell-free desensitization of opioid inhibition of adenylate cyclase in neuroblastoma X glioma NG108-15 hybrid cell membranes.
Neuroblastoma
Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase.
Neuroblastoma
Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line.
Neuroblastoma
Characterization of muscarinic receptors: type M2 (subtype B) on neuro-2A neuroblastoma cells.
Neuroblastoma
Cholera toxin covalently linked with horseradish peroxidase does not activate the adenylate cyclase of neuroblastoma cells.
Neuroblastoma
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Neuroblastoma
Chronic exposure of NG 108-15 cells to inhibitory acting drugs reduces stimulatory prostaglandin E1 receptor number.
Neuroblastoma
Comparison between vasoactive intestinal polypeptide and pituitary adenylate cyclase activating polypeptide levels in neuroblastoma tumour tissues.
Neuroblastoma
Comparison of binding affinities and adenylate cyclase inhibition for the determination of efficacy at mu-opioid receptors in a neuroblastoma cell line.
Neuroblastoma
Comparison of opiate inhibition of adenylate cyclase activity in neuroblastoma N18tG2 and neuroblastoma x glioma NG108-15 hybrid cell lines.
Neuroblastoma
Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression.
Neuroblastoma
Control of opiate receptor-adenylate cyclase interactions by calcium ions and guanosine-5'-triphosphate.
Neuroblastoma
Coriandrum sativum and Lavandula angustifolia Essential Oils: Chemical Composition and Activity on Central Nervous System.
Neuroblastoma
Cyclic AMP responsive element binding protein phosphorylation and DNA binding is decreased by chronic lithium but not valproate treatment of SH-SY5Y neuroblastoma cells.
Neuroblastoma
Cyclic AMP-mediated desensitization of D1 dopamine receptor-coupled adenylyl cyclase in NS20Y neuroblastoma cells.
Neuroblastoma
D1 dopamine receptors of NS20Y neuroblastoma cells are functionally similar to rat striatal D1 receptors.
Neuroblastoma
Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase.
Neuroblastoma
Decreased GTP-stimulated adenylyl cyclase activity in HPRT-deficient human and mouse fibroblast and rat B103 neuroblastoma cell membranes.
Neuroblastoma
Degradation of choleragen bound to cultured human fibroblasts and mouse neuroblastoma cells.
Neuroblastoma
delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells.
Neuroblastoma
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Neuroblastoma
Demonstration of acetylcholine-sensitive adenyl cyclase in malignant neuroblastoma cells in culutre.
Neuroblastoma
Demonstration of dopamine-sensitive adenylate cyclase in malignant neuroblastoma cells and change in sensitivity of adenylate cyclase to catecholamines in "differentiated" cells.
Neuroblastoma
Detection and analysis of agonist-induced formation of the complex of the stimulatory guanine nucleotide-binding protein with adenylate cyclase in intact wild-type and beta 2-adrenoceptor-expressing NG108-15 cells.
Neuroblastoma
Differentiation of human neuroblastoma cells: marked potentiation of prostaglandin E-stimulated accumulation of cyclic AMP by retinoic acid.
Neuroblastoma
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Neuroblastoma
Effect of alpha tocopheryl succinate on adenylate cyclase activity in murine neuroblastoma cells in culture.
Neuroblastoma
Effect of carbachol and 56 mm-potassium chloride on the cyclic AMP-mediated induction of tyrosine hydroxylase in neuroblastoma cells in culture.
Neuroblastoma
Effect of hyperthermia in combination with vitamin E and cyclic AMP on neuroblastoma cells in culture.
Neuroblastoma
Effect of lysolecithin of guanylate and adenylate cyclase activities in neuroblastoma cells in culture.
Neuroblastoma
Effect of neurotransmitters, Guanosine triphosphate, and divalent ions on the regulation of adenylate cyclase activity in malignant and adenosine cyclic 3':5'-monophosphate-induced "differentiated" neuroblastoma cells.
Neuroblastoma
Effect of phospholipases on chronic opiate action in neuroblastoma X glioma NG108-15 hybrid cells.
Neuroblastoma
Effects of adenosine analogues on basal, prostaglandin E1- and forskolin-stimulated cyclic AMP formation in intact neuroblastoma cells.
Neuroblastoma
Effects of amino and ammonio derivatives of adenosine on smooth muscle preparations and mouse neuroblastoma adenylate cyclase.
Neuroblastoma
Effects of chronic exposure to ethanol on the prostaglandin E1 receptor-mediated response and binding in a murine neuroblastoma clone (N1E-115).
Neuroblastoma
Effects of nitric oxide on adenylyl cyclase stimulation in N18TG2 neuroblastoma cells.
Neuroblastoma
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells.
Neuroblastoma
Efficacy and tolerance of narcotic analgesics at the mu opioid receptor in differentiated human neuroblastoma cells.
Neuroblastoma
Efficacy of inverse agonists in cells overexpressing a constitutively active beta2-adrenoceptor and type II adenylyl cyclase.
Neuroblastoma
Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization.
Neuroblastoma
Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization.
Neuroblastoma
Enhancement of cyclic AMP accumulation mediated by 5-HT after chronic amitriptyline treatment in NG 108-15 cells.
Neuroblastoma
Enkephalin inhibition of adenylate cyclase activity in neuroblastoma N18TG2 cells: effect of sulfatide incorporation.
Neuroblastoma
Evidence for co-expression and desensitization of A2a and A2b adenosine receptors in NG108-15 cells.
Neuroblastoma
Evidence for [D-Ala2,D-Leu5]enkephalin-induced supersensitivity to 5-hydroxytryptamine in a neurotumor x brain hybrid cell line (NCB-20).
Neuroblastoma
Factors affecting prostacyclin receptor agonist efficacy in different cell types.
Neuroblastoma
Functional vasoactive intestinal polypeptide (VIP) receptors in human neuroblastoma subclones that contain VIP precursor mRNA and release VIP-like substances.
Neuroblastoma
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni.
Neuroblastoma
G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells.
Neuroblastoma
Gs alpha-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells.
Neuroblastoma
Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors.
Neuroblastoma
Guanine nucleotide-independent inhibition of adenylate cyclase by a stimulatory hormone.
Neuroblastoma
Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
Neuroblastoma
High-affinity calmodulin binding is required for the rapid entry of Bordetella pertussis adenylyl cyclase into neuroblastoma cells.
Neuroblastoma
Human A-type ANP receptor upregulation by PACAP and carbachol in neuroblastoma cells.
Neuroblastoma
Identification and characterization of functional D1 dopamine receptors in a human neuroblastoma cell line.
Neuroblastoma
Identification of a domain in Bordetella pertussis adenylyl cyclase important for subunit interactions and cell invasion activity.
Neuroblastoma
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool.
Neuroblastoma
Increased expression of ubiquitin during adenosine 3',5'-cyclic monophosphate-induced differentiation of neuroblastoma cells in culture.
Neuroblastoma
Independent regulation of receptor-mediated cell depolarization and adenylate cyclase by 5-hydroxytryptamine (serotonin) in neuroblastoma hybrid cells [proceedings]
Neuroblastoma
Induction of adenylate cyclase sensitive dopamine D2-receptors in retinoic acid induced differentiated human neuroblastoma SHSY-5Y cells.
Neuroblastoma
Induction of catecholamine-responsive adenylate cyclase in HeLa cells by sodium butyrate. Evidence for a more efficient stimulatory regulatory component.
Neuroblastoma
Inhibition by ethanol of forskolin-stimulated adenylate cyclase in a murine neuroblastoma clone (N1E-115).
Neuroblastoma
Inhibition by lithium of PGE1-sensitive adenylate cyclase in neuroblastoma X glioma hybrid cells: approach to the attenuation of the opiate withdrawal syndrome.
Neuroblastoma
Inhibition by methylmercuric chloride of prostaglandin E1-sensitive adenylate cyclase activity in glioma but not in neuroblastoma cells in culture.
Neuroblastoma
Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7).
Neuroblastoma
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells.
Neuroblastoma
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Neuroblastoma
Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment.
Neuroblastoma
Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds.
Neuroblastoma
Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
Neuroblastoma
Interaction among mu-opioid receptors and alpha 2-adrenoceptors on SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Interaction of 2',3'-di-O-nitro-5'-(N-ethylcarboxamido)adenosine with adenosine receptors in intestinal smooth muscle.
Neuroblastoma
Interaction of clonidine and clonidine analogues with alpha-adrenergic receptors of neuroblastoma X glioma hybrid cells and rat brain: comparison of ligand binding with inhibition of adenylate cyclase.
Neuroblastoma
Interaction of delta-opioid receptors with multiple G proteins: a non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins.
Neuroblastoma
Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells.
Neuroblastoma
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
Neuroblastoma
Isolation of a protein fraction from Bordetella pertussis that facilitates entry of the calmodulin-sensitive adenylate cyclase into animal cells.
Neuroblastoma
Lipid requirement for long-lived morphine-dependent activations of adenylate cyclase of neuroblastoma X glioma hybrid cells.
Neuroblastoma
Long-term morphine treatment enhances proteasome-dependent degradation of G beta in human neuroblastoma SH-SY5Y cells: correlation with onset of adenylate cyclase sensitization.
Neuroblastoma
Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.
Neuroblastoma
Manganese inhibits adenylate cyclase activity and stimulates phosphodiesterase activity in neuroblastoma cells: its possible implication in manganese-poisoning.
Neuroblastoma
Maxadilan interacts with receptors for pituitary adenylyl cyclase activating peptide in human SH-SY5Y and SK-N-MC neuroblastoma cells.
Neuroblastoma
Mechanism of action of cholera toxin on intact cells. Generation of A1 peptide and activation of adenylate cyclase.
Neuroblastoma
Membrane fatty acids, lipid peroxidation and adenylate cyclase activity in cultured neural cells.
Neuroblastoma
Modification of neuroblastoma x glioma hybrid NG108-15 adenylate cyclase by vanadium ions.
Neuroblastoma
Modification of receptor-mediated inhibition of adenylate cyclase in NG108-15 neuroblastoma X glioma cells by n-ethylmaleimide.
Neuroblastoma
Modulation of adenylate cyclase activity by a cytosolic factor following chronic opiate exposure in neuroblastoma x glioma NG108-15 hybrid cells.
Neuroblastoma
Modulation of sodium-sensitive GTPase by partial opiate agonists. An explanation for the dual requirement for Na+ and GTP in inhibitory regulation of adenylate cyclase.
Neuroblastoma
Molecular cloning and expression of a D1 dopamine receptor linked to adenylyl cyclase activation.
Neuroblastoma
Morphine dependence in human neuroblastoma SH-SY5Y cells is associated with adaptive changes in both the quantity and functional interaction of PGE1 receptors and stimulatory G proteins.
Neuroblastoma
Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity.
Neuroblastoma
Mouse neuroblastoma cell adenylate cyclase: regulation by 2-chloroadenosine, prostaglandin E1 and the cations Mg2+, Ca2+ and Mn2+.
Neuroblastoma
Mu and delta opiate receptors coupled negatively to adenylate cyclase on embryonic neurons from the mouse striatum in primary cultures.
Neuroblastoma
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
Neuroblastoma
Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation.
Neuroblastoma
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Neuroblastoma
Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin.
Neuroblastoma
Muscarinic pharmacology of the inhibition of adenylate cyclase in N18TG2 neuroblastoma cells.
Neuroblastoma
Muscarinic receptor regulation of NG108-15 adenylate cyclase: requirement for Na+ and GTP.
Neuroblastoma
Neuroblastoma adenylate cyclase. Role of 2-chloroadenosine, prostaglandin E1, and guanine nucleotides in regulation of activity.
Neuroblastoma
Neuroblastoma cell adenylate cyclase: direct activation by adenosine and prostaglandins.
Neuroblastoma
Neuroblastoma X glioma NG108-15 hybrid cells cultured in a serum-free chemically defined medium: effects on acute and chronic opiate regulation of adenylate cyclase activity.
Neuroblastoma
Neuroprotective Effect of PACAP on Translational Control Alteration and Cognitive Decline in MPTP Parkinsonian Mice.
Neuroblastoma
Neurotensin-mediated inhibition of cyclic AMP formation in neuroblastoma N1E115 cells: involvement of the inhibitory GTP-binding component of adenylate cyclase.
Neuroblastoma
Ni-coupled receptors in cultured neural hybrid cells: cell specificity for dibutyryl cyclic AMP-induced down-regulation but not morphological differentiation.
Neuroblastoma
Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model.
Neuroblastoma
NPY-stimulated Ca2+ mobilization in SK-N-MC cells is enhanced after isoproterenol treatment.
Neuroblastoma
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Neuroblastoma
Pereskia aculeata Muller (Cactaceae) Leaves: Chemical Composition and Biological Activities.
Neuroblastoma
Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Photolabile opioid derivatives of D-Ala2-Leu5-enkephalin and their interactions with the opiate receptor.
Neuroblastoma
Pituitary adenylate cyclase activating peptide and its receptors are expressed in human neuroblastomas.
Neuroblastoma
Pituitary adenylate cyclase activating peptide and vasoactive intestinal polypeptide: differentiation effects on human neuroblastoma NB-OK-1 cells.
Neuroblastoma
Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in ganglioneuroblastoma and neuroblastoma.
Neuroblastoma
Potentiation of opiate action in neuroblastoma N18TG2 cells by lipid incorporation.
Neuroblastoma
Production of immunoreactive pituitary adenylate cyclase activating polypeptide (PACAP) by human neuroblastoma cells, IMR-32: detection and characterization with monoclonal and polyclonal antibodies against different epitopes of PACAP.
Neuroblastoma
Prolonged exposure of human neuroblastoma SH-SY5Y cell line to morphine and oxotremorine modulates signal transduction in adenylate cyclase system.
Neuroblastoma
Prostaglandin E1-mediated, cyclic AMP-independent, down-regulation of Gs alpha in neuroblastoma x glioma hybrid cells.
Neuroblastoma
Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via ?-catenin stabilization.
Neuroblastoma
Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists.
Neuroblastoma
Protein kinase C regulates adenosine A2a receptor mRNA expression in SH-SY5Y cells.
Neuroblastoma
Quantitative stoichiometry of the proteins of the stimulatory arm of the adenylyl cyclase cascade in neuroblastoma x glioma hybrid, NG108-15 cells.
Neuroblastoma
Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies.
Neuroblastoma
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. I. Inhibition of adenylate cyclase mediated by alpha receptors.
Neuroblastoma
Regulation of adenylate cyclase of neuroblastoma x glioma hybrid cells by alpha-adrenergic receptors. II. Long lived increase of adenylate cyclase activity mediated by alpha receptors.
Neuroblastoma
Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade.
Neuroblastoma
Regulation of cellular Gs alpha levels and basal adenylyl cyclase activity by expression of the beta 2-adrenoceptor in neuroblastoma cell lines.
Neuroblastoma
Regulation of Gi by the CB1 cannabinoid receptor C-terminal juxtamembrane region: structural requirements determined by peptide analysis.
Neuroblastoma
Regulation of stimulatory adenylyl cyclase signaling during forskolin-induced differentiation of mouse neuroblastoma x rat glioma (NG108-15) cells.
Neuroblastoma
Relationship between desensitization and sequestration of muscarinic cholinergic receptors in two neuronal cell lines.
Neuroblastoma
Remifentanil produces cross-desensitization and tolerance with morphine on the mu-opioid receptor.
Neuroblastoma
Retinoic acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines.
Neuroblastoma
Retinoic acid-induced regulation of neuropeptide Y receptor expression and function in the neuroepithelioma line SK-N-MC.
Neuroblastoma
Role of phosphodiesterase II in cross talk between cGMP and cAMP in human neuroblastoma NB-OK-1 cells.
Neuroblastoma
Secretin receptors on neuroblastoma cell membranes: characterization of 125I-labeled secretin binding and association with adenylate cyclase.
Neuroblastoma
Segregation of discrete GS alpha-mediated responses that accompany homologous or heterologous desensitization in two related somatic hybrids.
Neuroblastoma
Sensitization of neuronal A2A adenosine receptors after persistent D2 dopamine receptor activation.
Neuroblastoma
Serotonin receptor-mediated activation of adenylate cyclase in the neuroblastoma NCB.20: a novel 5-hydroxytryptamine receptor.
Neuroblastoma
Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells.
Neuroblastoma
SK-N-BE: a human neuroblastoma cell line containing two subtypes of delta-opioid receptors.
Neuroblastoma
Specific receptor-mediated inhibition of cyclic AMP synthesis by dopamine in a neuroblastoma X brain hybrid cell line NCB-20.
Neuroblastoma
Specificity of interactions of receptors and effectors with GTP-binding proteins in native membranes.
Neuroblastoma
Stereospecific and nonstereospecific effects of (+)- and (-)-morphine: evidence for a new class of receptors?
Neuroblastoma
Stimulation of adenylyl cyclase mediated by phospholipase C-linked M3 muscarinic receptor in human neuroblastoma SK-N-BE (2) C cells.
Neuroblastoma
Stimulation of neuroblastoma adenylate cyclase by arachidonic acid metabolites.
Neuroblastoma
Structural requirements for the binding of the pituitary adenylate-cyclase-activating peptide to receptors and adenylate-cyclase activation in pancreatic and neuronal membranes.
Neuroblastoma
Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist.
Neuroblastoma
Studies of the regulation of basal adenylate cyclase activity by membrane polyunsaturated fatty acids in cultured neuroblastoma.
Neuroblastoma
Synergistic activation of adenylyl cyclase is dependent upon phospholipase C-mediated processes in human neuroblastoma SK-N-BE(2)C cells.
Neuroblastoma
The coupling of muscarinic receptors to hydrolysis of inositol lipids in human neuroblastoma SH-SY5Y cells.
Neuroblastoma
The delta-opioid receptor in SK-N-BE human neuroblastoma cell line undergoes heterologous desensitization.
Neuroblastoma
The effects of exposure to unsaturated fatty acids on opiate receptors, prostaglandin E1 receptors, and adenylate cyclase activity of neuroblastoma x glioma hybrid cells.
Neuroblastoma
The expression of a novel Ca2+/CaM stimulated adenylyl cyclase activity in the neuroblastoma cell line Lan-1 is regulated by cell density.
Neuroblastoma
The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity.
Neuroblastoma
The interaction of Ca2+ with the calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
Neuroblastoma
The novel VIP-like hypothalamic polypeptide PACAP interacts with high affinity receptors in the human neuroblastoma cell line NB-OK.
Neuroblastoma
The role and specificity of guanine nucleotide binding proteins in receptor-effector coupling.
Neuroblastoma
Thyroid effects on adenosine 3',5'-monophosphate levels and adenylate cyclase in cultured neuroblastoma cells.
Neuroblastoma
Transfer of functional opiate receptors from membranes to recipient cells by polyethylene glycol-induced fusion.
Neuroblastoma
Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells.
Neuroblastoma
Up-regulation of a constitutively active form of the beta2-adrenoceptor by sustained treatment with inverse agonists but not antagonists.
Neuroblastoma
Up-regulation of angiotensin II receptors by in vitro differentiation of murine N1E-115 neuroblastoma cells.
Neuroblastoma
[3H]propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
Neuroblastoma
[Adenylate cyclase in synchronized neuroblastoma cells: enzyme response during the cell cycle]
Neuroblastoma
[Change in adenyl cyclase activity in the differentiation of neuroblastoma cells]
Neurodegenerative Diseases
Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders.
Neurodegenerative Diseases
cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.
Neurodegenerative Diseases
Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration.
Neurodegenerative Diseases
Neurodegenerative disease: Pituitary adenylate cyclase activator ameliorates SBMA.
Neurodegenerative Diseases
Pituitary adenylate cyclase activating polypeptide in the retina: focus on the retinoprotective effects.
Neurodegenerative Diseases
Pituitary Adenylyl Cyclase Activating Polypeptide (PACAP) Signaling and the Cell Cycle Machinery in Neurodegenerative Diseases.
Neurodegenerative Diseases
Protective role of endogenous PACAP in inflammation-induced retinal degeneration.
Neurodegenerative Diseases
The Protective Role of PAC1-Receptor Agonist Maxadilan in BCCAO-Induced Retinal Degeneration.
Neurodegenerative Diseases
Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury.
Neuroectodermal Tumors, Primitive
Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.
Neuroendocrine Tumors
Peptide receptors in neuroendocrine tumors of the lung as potential tools for radionuclide diagnosis and therapy.
Neuroendocrine Tumors
Retinoic acid regulation of the VIP and PACAP autocrine ligand and receptor system in human neuroblastoma cell lines.
Neurofibromatoses
Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways.
Neurofibromatoses
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras.
Neurofibromatosis 1
Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways.
Neurofibromatosis 1
Effect of neurofibromatosis type I mutations on a novel pathway for adenylyl cyclase activation requiring neurofibromin and Ras.
Neurofibromatosis 1
Gamma neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila.
Neurofibrosarcoma
Aberrant cAMP Metabolism in NF1 Malignant Peripheral Nerve Sheath Tumor Cells.
Neurogenic Inflammation
Effect of pituitary adenylate cyclase activating polypeptide-38 on sensory neuropeptide release and neurogenic inflammation in rats and mice.
Neurogenic Inflammation
Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat.
Neuroinflammatory Diseases
Implications of VIP and PACAP in Parkinson's disease: what do we know so far?
Neuromuscular Diseases
The metabolism of cyclic-3'-5'-adenosine monophosphate (cAMP) in diseased muscle.
Obesity
A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.
Obesity
A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.
Obesity
Adenylate cyclase activity in brown adipose tissue of the genetically obese (ob/ob) mouse.
Obesity
Adenylyl cyclase 3 haploinsufficiency confers susceptibility to diet-induced obesity and insulin resistance in mice.
Obesity
Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance.
Obesity
Alpha-subunits of Gs and Gi in adipocyte plasma membranes of genetically diabetic (db/db) mice.
Obesity
Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humans.
Obesity
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Obesity
Application of agents active at the alpha 2-adrenoceptor of fat cells to the treatment of obesity--a critical appraisal.
Obesity
Beta 3-adrenergic activation of adenylyl cyclase in mouse white adipocytes: modulation by GTP and effect of obesity.
Obesity
Beta-adrenergic responsiveness of adenylate cyclase in human adipocyte plasma membranes in obesity and after massive weight reduction.
Obesity
Defective stimulation of adipocyte adenylate cyclase, blunted lipolysis, and obesity in pseudohypoparathyroidism 1a.
Obesity
Disruption of type 3 adenylyl cyclase expression in the hypothalamus leads to obesity.
Obesity
Effect of the genetic background and specific mutation on adenylate cyclase activity in obesity syndromes.
Obesity
Effects of Whole-Body Adenylyl Cyclase 5 (Adcy5) Deficiency on Systemic Insulin Sensitivity and Adipose Tissue.
Obesity
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men.
Obesity
Hepatic adenylate cyclase 3 is upregulated by Liraglutide and subsequently plays a protective role in insulin resistance and obesity.
Obesity
Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study.
Obesity
Insulin downregulates M(2)-muscarinic receptors in adult rat atrial cardiomyocytes: a link between obesity and cardiovascular complications.
Obesity
Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating.
Obesity
Quantitation of inhibitory G-proteins in fat cells of obese and normal-weight human subjects.
Obesity
Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial ?-adrenergic system and does not compromise cardiac function.
Obesity
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
Obesity
[Attenuation of inhibitory influence of hormones on adenylyl cyclase systems in the myocardium and brain of rats with obesity and type 2 diabetes mellitus and effect of intranasal insulin on it].
Obesity
[BETA-ADRENERGIC REGULATION OF THE ADENYLYL CYCLASE SIGNALING SYSTEM IN MYOCARDIUM AND BRAIN OF RATS WITH OBESITY AND TYPES 2 DIABETES MELLITUS AND THE EFFECT OF LONG-TERM INTRANASAL INSULIN TREATMENT].
Obesity
[THE EFFECTS OF LONG-TERM METFORMIN TREATMENT ON THE ACTIVITY OF ADENYLYL CYCLASE SYSTEM AND NO-SYNTHASES IN THE BRAIN AND THE MYOCARDIUM OF RATS WITH OBESITY].
Obstetric Labor, Premature
Adenosine 3',5'-monophosphate analogs and beta-adrenergic agonists induce the synthesis of the major surfactant apoprotein in human fetal lung in vitro.
Ocular Hypotension
Stimulatory effects of prostaglandin D2 analogues on adenylate cyclase in rabbit iris-ciliary body membrane fractions.
Ocular Motility Disorders
Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease.
Optic Nerve Injuries
Effects of PACAP on Intracellular Signaling Pathways in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress.
Osteogenesis Imperfecta
The new bone biology: pathologic, molecular, and clinical correlates.
Osteolysis
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
Osteomalacia
Humoral hypercalcaemia of malignancy: report of two further patients with biochemical studies on tumour extracts.
Osteomalacia
Parathyroid hormone-like bioactivity in tumours from patients with oncogenic osteomalacia.
Osteoporosis
By inhibiting ADCY5, miR-18a-3p promotes osteoporosis and possibly contributes to spinal fracture.
Osteosarcoma
1,25-Dihydroxycholecalciferol and glucocorticosteroid regulation of adenylate cyclase in an osteoblast-like cell line.
Osteosarcoma
1,25-dihydroxyvitamin D-3 and 24,25-dihydroxyvitamin D-3 affect parathormone (PTH) -sensitive adenylate cyclase activity and alkaline phosphatase secretion of osteoblastic cells through different mechanisms of action.
Osteosarcoma
Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption.
Osteosarcoma
Adenylate cyclase of osteoblast-like cells from rat osteosarcoma is stimulated by calcitonin as well as parathyroid hormone.
Osteosarcoma
Alterations in hormone-sensitive adenylate cyclase of cloned rat osteosarcoma cells during long-term culture.
Osteosarcoma
An adenylate cyclase activating factor in cytosol of rat osteogenic sarcoma [proceedings]
Osteosarcoma
Analogues of human parathyroid hormone (1-31)NH(2): further evaluation of the effect of conformational constraint on biological activity.
Osteosarcoma
Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: cyclic lactams of the receptor binding region.
Osteosarcoma
Bone and kidney adenylate cyclase-stimulating activity produced by a hypercalcemic canine adenocarcinoma line (CAC-8) maintained in nude mice.
Osteosarcoma
Calcitonin gene-related peptide (CGRP) acts independently of calcitonin on cyclic AMP formation in clonal osteogenic sarcoma cells (UMR 106-01).
Osteosarcoma
Calcitonin gene-related peptide (CGRP) increases intracellular free Ca2+ concentrations but not cyclic AMP formation in CGRP receptor-positive osteosarcoma cells (OHS-4).
Osteosarcoma
Characteristics of prostate-derived growth factors for cells of the osteoblast phenotype.
Osteosarcoma
Characterization of an osteoblast-like clonal cell line which responds to both parathyroid hormone and calcitonin.
Osteosarcoma
Comparison of bone and osteosarcoma adenylate cyclase. Effects of Mg2+, Ca2+, ATP4- and HATP3- in the assay mixture.
Osteosarcoma
Comparison of bone and osteosarcoma adenylate cyclase. Partial purification of membranes and kinetic properties of enzyme.
Osteosarcoma
Comparison of renal and osseous binding of parathyroid hormone and hormonal fragments.
Osteosarcoma
Dexamethasone increases G alpha q-11 expression and hormone-stimulated phospholipase C activity in UMR-106-01 cells.
Osteosarcoma
Differential effects of parathyroid hormone and its analogues on cytosolic calcium ion and cAMP levels in cultured rat osteoblast-like cells.
Osteosarcoma
Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation.
Osteosarcoma
Effect of 1,25-dihydroxyvitamin D3 on cyclic AMP responses to hormones in clonal osteogenic sarcoma cells.
Osteosarcoma
Effects of retinoic acid on alkaline phosphatase messenger ribonucleic acid, catecholamine receptors, and G proteins in ROS 17/2.8 cells.
Osteosarcoma
Estimation of biologically active intact parathyroid hormone in normal and hyperparathyroid sera by sequential N-terminal immunoextraction and midregion radioimmunoassay.
Osteosarcoma
Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcaemia of malignancy.
Osteosarcoma
Expression and characterization of a recombinant human parathyroid hormone secreted by Escherichia coli employing the staphylococcal protein A promoter and signal sequence.
Osteosarcoma
Formycin 5'-triphosphate, a fluorescent analog of ATP, as a substrate for adenylate cyclase.
Osteosarcoma
Glucocorticoid and 1,25-dihydroxyvitamin D modulate the degree of adenosine 3',5'-monophosphate-dependent protein kinase isoenzyme I and II activation by parathyroid hormone in rat osteosarcoma cells.
Osteosarcoma
Gold(III) inhibits activated human osteosarcoma adenylate cyclase by an action at or near the catalytic component.
Osteosarcoma
High-yield expression of fully bioactive N-terminal parathyroid hormone analog in Escherichia coli.
Osteosarcoma
Humoral hypercalcaemia of malignancy: report of two further patients with biochemical studies on tumour extracts.
Osteosarcoma
Influence of the amino-terminus on in vitro and in vivo biological activity of synthetic parathyroid hormone-like peptides of malignancy.
Osteosarcoma
Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
Osteosarcoma
Inorganic Phosphate as A Signaling Molecule: A Potential Strategy in Osteosarcoma Treatment.
Osteosarcoma
Inorganic phosphate enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin via a p53-dependent pathway.
Osteosarcoma
Insulin sensitizes a cultured rat osteogenic sarcoma cell line to hormones which activate adenylate cyclase.
Osteosarcoma
Interactive regulation of signalling pathways in bone cells: possible modulation of PGE2-stimulated adenylyl cyclase activity by protein kinase C.
Osteosarcoma
Interleukin-1 beta induces the synthesis of adenylyl cyclase in Swiss 3T3 fibroblasts and MG-63 osteosarcoma cells.
Osteosarcoma
Lactam formation increases receptor binding, adenylyl cyclase stimulation and bone growth stimulation by human parathyroid hormone (hPTH)(1-28)NH2.
Osteosarcoma
Large scale preparation of recombinant human parathyroid hormone 1-84 from Escherichia coli.
Osteosarcoma
Mechanisms of homologous and heterologous regulation of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106.
Osteosarcoma
Membranes from a transplantable osteogenic sarcoma responsive to parathyroid hormone and prostaglandins: regulation of adenylate cyclase and of hormone metabolism.
Osteosarcoma
NHERF1 regulates parathyroid hormone receptor desensitization: interference with beta-arrestin binding.
Osteosarcoma
Osteosarcoma cytosol factor promotes parathyroid hormone stimulation of adenylate cyclase independent of GTP.
Osteosarcoma
Oxidation of recombinant human parathyroid hormone: effect of oxidized position on the biological activity.
Osteosarcoma
Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells. Hormone competition and site heterogeneity.
Osteosarcoma
Parathyroid hormone fragment [3-34] stimulates protein kinase C (PKC) activity in rat osteosarcoma and murine T-lymphoma cells.
Osteosarcoma
Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase.
Osteosarcoma
Parathyroid hormone stimulation of the Na+/K+ pump in rat clonal osteosarcoma cells.
Osteosarcoma
Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
Osteosarcoma
Proceedings: hormone-responsive adenylate cyclase in a transplantable osteogenic sarcoma in the rat.
Osteosarcoma
Production and characterisation of immunoreactive calcitonin gene-related peptide (CGRP) from a CGRP receptor-positive cloned osteosarcoma cell line (UMR 106.01).
Osteosarcoma
Properties of a factor in cytosol that enhances hormones-stimulated adenylate cyclase activity.
Osteosarcoma
Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells.
Osteosarcoma
Purification of peptides with parathyroid hormone-like bioactivity from human and rat malignancies associated with hypercalcemia.
Osteosarcoma
Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2).
Osteosarcoma
Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity.
Osteosarcoma
Receptor activator of NF-kappaB ligand protein expression in UMR-106 cells is differentially regulated by parathyroid hormone and calcitriol.
Osteosarcoma
Regulation in vivo of the growth of Leydig cell tumors by antisense ribonucleic acid for parathyroid hormone-related peptide.
Osteosarcoma
Skeletal alkaline phosphatase specific activity is an index of the osteoblastic phenotype in subpopulations of the human osteosarcoma cell line SaOS-2.
Osteosarcoma
Stimulation of femoral trabecular bone growth in ovariectomized rats by human parathyroid hormone (hPTH)-(1-30)NH(2).
Osteosarcoma
Stimulation of membrane-associated protein kinase-C activity in spleen lymphocytes by hPTH-(1-31)NH2, its lactam derivative, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, and hPTH-(1-30)NH2.
Osteosarcoma
Synthesis of a gene encoding parathyroid hormone-like protein-(1-141): purification and biological characterization of the expressed protein.
Osteosarcoma
Synthesis of human parathyroid-hormone-related protein(1-141) in Saccharomyces cerevisiae. A correct amino-terminal processing vital for the hormone's biological activity is obtained by an ubiquitin fusion protein approach.
Osteosarcoma
Synthetic parathyroid hormone-like protein-(1-74): biochemical and physiological characterization.
Osteosarcoma
Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.
Osteosarcoma
The biological properties of bovine parathyroid hormone (1-41), a fragment generated from the native hormone by human leukocytes.
Osteosarcoma
The bovine renal parathyroid hormone (PTH) receptor has equal affinity for two different amino acid sequences: the receptor binding domains of PTH and PTH-related protein are located within the 14-34 region.
Osteosarcoma
The effect of 1,25-dihydroxyvitamin D3 on human osteoblast-like osteosarcoma cell: modification of response to PTH.
Osteosarcoma
The inhibitory guanine nucleotide regulatory protein modulates agonist-stimulated cAMP production in rat osteosarcoma cells.
Osteosarcoma
The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.
Osteosarcoma
The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays.
Osteosarcoma
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
Osteosarcoma
Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists.
Osteosarcoma
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Osteosarcoma
Two species of adenylate cyclase-stimulating activity in a murine squamous carcinoma model of humoral hypercalcemia of malignancy.
Osteosarcoma
Type-1 parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptors activate phospholipase C in response to carboxyl-truncated analogs of PTH(1-34).
Ovarian Neoplasms
Adenylate cyclase in human ovarian cancers: sensitivity to gonadotropins and nonhormonal activators.
Ovarian Neoplasms
Pituitary adenylate cyclase activating polypeptide (PACAP) in human ovarian cancers.
Pancreatic Neoplasms
Adenylyl cyclase 3/adenylyl cyclase-associated protein 1 (CAP1) complex mediates the anti-migratory effect of forskolin in pancreatic cancer cells.
Pancreatic Neoplasms
cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition.
Pancreatic Neoplasms
Forskolin and phorbol ester have opposite effects on the expression of mucin-associated sialyl-Lewis(a) in pancreatic cancer cells.
Pancreatic Neoplasms
Inhibition of renal membrane adenylate cyclase by extract of pancreatic cancer associated with humoral hypercalcemia of malignancy.
Pancreatic Neoplasms
Purification and partial sequencing of inhibitory factor on renal membrane adenylate cyclase in pancreatic cancer extract: identity with histones H1b or H1d.
Pancreatic Neoplasms
Secretion of MUC5AC mucin from pancreatic cancer cells in response to forskolin and VIP.
Pancreatitis
Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats.
Pancreatitis
[Effects of analogs of pituitary adenylate cyclase activating polypeptide on acute pancreatitis in rats]
Pancreatitis, Acute Hemorrhagic
Adenyl cyclase and cyclic AMP (cAMP) in acute experimental pancreatitis.
Papilloma
Phorbol myristate acetate uncouples the relationship between beta-adrenergic receptors and adenyl cyclase in mouse epidermis: a phenotypic trait in papillomas.
Paralysis
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Paralysis
Interaction of lipopolysaccharide endotoxin produced from Escherichia coli with D-tubocurarine at the nicotinic2 receptor and adenosine 3':5' cyclic monophosphate during physiological contraction in skeletal muscle.
Paraparesis, Spastic
Child Neurology: Spastic paraparesis and dystonia with a novel ADCY5 mutation.
Parathyroid Neoplasms
Adenylate cyclase activity in human parathyroid tissues: reduced sensitivity to suppression by calcium in parathyroid adenomas as compared with normal glands form normocalcemic subjects or noninvolved glands from hyperparathyroid subjects.
Parathyroid Neoplasms
Human parathyroid adenoma adenylate cyclase: stimulation by histamine that is blocked by cimetidine.
Parkinson Disease
Antagonism of striatal muscarinic receptors inhibiting dopamine D1 receptor-stimulated adenylyl cyclase activity by cholinoceptor antagonist used to treat Parkinson's disease.
Parkinson Disease
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Parkinson Disease
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.
Parkinson Disease
Dopamine-sensitive adenylate cyclase activity in the caudate nucleus and adrenal medulla in Parkinson's disease and in liver cirrhosis.
Parkinson Disease
Dopamine-sensitive adenylate cyclase activity in the striatum in Parkinson's disease.
Parkinson Disease
Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications.
Parkinson Disease
Effects of pituitary adenylate cyclase activating polypeptide and its fragments on retinal degeneration induced by neonatal monosodium glutamate treatment.
Parkinson Disease
Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on l-dopa dependent animal involuntary movements in rats.
Parkinson Disease
Impaired ?-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.
Parkinson Disease
Implications of VIP and PACAP in Parkinson's disease: what do we know so far?
Parkinson Disease
Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease.
Parkinson Disease
Opposing effects of dopaminergic to cholinergic compounds on a cerebral dopamine-activated adenylate cyclase.
Parkinson Disease
Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells.
Parkinson Disease
Pituitary adenylate cyclase activating polypeptide protects dopaminergic neurons and improves behavioral deficits in a rat model of Parkinson's disease.
Parkinson Disease
Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats.
Parkinson Disease
Sensitization of dopamine-stimulated adenylyl cyclase in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys and patients with idiopathic Parkinson's disease.
Parkinson Disease
SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?
Parkinson Disease
The alleged dopamine D1 receptor agonist SKF 83959 is a dopamine D1 receptor antagonist in primate cells and interacts with other receptors.
Parkinson Disease
The differential behavioural effects of benzazepine D1 dopamine agonists with varying efficacies, co-administered with quinpirole in primate and rodent models of Parkinson's disease.
Parkinson Disease
[Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease]
Parkinsonian Disorders
Dopamine-stimulated adenylate cyclase activity in the human brain: changes in Parkinsonism.
Peptic Ulcer
Human gastric mucosal adenylate cyclase: activation by histamine-H2-receptor stimulation and inhibition by cimetidine in vitro and in peptic ulcer patients.
Peptic Ulcer
Peptic ulcer disease: absence of antibodies stimulating the histamine sensitive adenylate cyclase of gastric mucosal cells.
Perinephritis
Alterations of the glomerular beta-adrenoceptor-linked adenylate cyclase system in perinephritis hypertension.
Periodontitis
Enhancement of carbachol-induced amylase secretion in parotid glands from rats with experimental periodontitis.
Periodontitis
[Adenylate cyclase and guanylate cyclase in the saliva of healthy persons and in periodontitis]
Peripheral Nerve Injuries
Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration.
Peripheral Nerve Injuries
Injury-associated PACAP expression in rat sensory and motor neurons is induced by endogenous BDNF.
Peripheral Nerve Injuries
Pituitary adenylate cyclase activating peptide expression in the rat dorsal root ganglia: up-regulation after peripheral nerve injury.
Persistent Infection
Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity.
Pheochromocytoma
7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.
Pheochromocytoma
A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.
Pheochromocytoma
A2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase.
Pheochromocytoma
Adrenal pheochromocytoma PC12h cells respond to pituitary adenylate cyclase activating polypeptide.
Pheochromocytoma
Analogs of caffeine: antagonists with selectivity for A2 adenosine receptors.
Pheochromocytoma
Cooperative regulation of neurotensin content in PC12 pheochromocytoma cell cultures: effects of nerve growth factor, dexamethasone, and activators of adenylate cyclase.
Pheochromocytoma
Definition of subclasses of adenosine receptors associated with adenylate cyclase: interaction of adenosine analogs with inhibitory A1 receptors and stimulatory A2 receptors.
Pheochromocytoma
Differential response of adenylate cyclase and ATPase activities after chronic ethanol exposure of PC12 cells.
Pheochromocytoma
Direct anesthetic-like effects of forskolin on the nicotinic acetylcholine receptors of PC12 cells.
Pheochromocytoma
Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.
Pheochromocytoma
Enhancement of depolarization-dependent neurosecretion from PC12 cells by forskolin-induced elevation of cyclic AMP.
Pheochromocytoma
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner.
Pheochromocytoma
Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells.
Pheochromocytoma
Hypertrophy of pheochromocytoma cells treated with nerve growth factor and activators of adenylate cyclase.
Pheochromocytoma
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Pheochromocytoma
Molecular and pharmacological characterization of somatostatin receptor subtypes in adrenal, extraadrenal, and malignant pheochromocytomas.
Pheochromocytoma
N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.
Pheochromocytoma
Pituitary adenylate cyclase activating polypeptide (PACAP)-like immunoreactivity in pheochromocytomas.
Pheochromocytoma
Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response.
Pheochromocytoma
Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway.
Pheochromocytoma
Regulation of adenylyl cyclase type VI activity during desensitization of the A2a adenosine receptor-mediated cyclic AMP response: role for protein phosphatase 2A.
Pheochromocytoma
Regulation of neurotensin content in adrenal medullary cells: comparison of PC12 cells to normal rat chromaffin cells in vitro.
Pheochromocytoma
Structure-activity relationships for 2-substituted adenosines at A1 and A2 adenosine receptors.
Pheochromocytoma
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.
Pheochromocytoma
The influence of nerve growth factor on the activities of adenylate cyclase and high-affinity GTPase in pheochromocytoma PC12 cell.
Pheochromocytoma
Tyrosine hydroxylase is activated and phosphorylated on different sites in rat pheochromocytoma PC12 cells treated with phorbol ester and forskolin.
Pick Disease of the Brain
Adenosine A2A receptors are up-regulated in Pick's disease frontal cortex.
Pinealoma
Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.
Pituitary ACTH Hypersecretion
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
Pituitary ACTH Hypersecretion
VIP stimulates ACTH release and adenylate cyclase in human ACTH-secreting pituitary adenomas.
Pituitary Neoplasms
'Cross-talk' between phospholipase C and adenylyl cyclase involves regulation of G-protein levels in GH3 rat pituitary cells.
Pituitary Neoplasms
7-OH-DPAT antagonizes dopamine D2 receptor-inhibited adenylyl cyclase activity.
Pituitary Neoplasms
A new constitutively activating mutation of the Gs protein alpha subunit-gsp oncogene is found in human pituitary tumours.
Pituitary Neoplasms
A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity.
Pituitary Neoplasms
A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents.
Pituitary Neoplasms
Activation of Na+ channels in GH3 cells and human pituitary adenoma cells by PACAP.
Pituitary Neoplasms
Adenylate cyclase of GH and ACTH producing tumors of human: activation by non-specific hormones and other bioactive substances.
Pituitary Neoplasms
Adenylyl cyclase and cyclic nucleotide phosphodiesterases in GH-Strains of rat pituitary cells.
Pituitary Neoplasms
Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells.
Pituitary Neoplasms
Characterization of D-2 dopamine receptors in a tumor of the rat anterior pituitary gland.
Pituitary Neoplasms
Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein.
Pituitary Neoplasms
Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase.
Pituitary Neoplasms
Corticotropin releasing factor stimulates cAMP formation in pituitary corticotropic tumor cells.
Pituitary Neoplasms
Effect of somatostatin on growth hormone release by MtT-F4 rat pituitary tumor in vitro.
Pituitary Neoplasms
Effects of long term treatment with corticotropin releasing factor on corticotropic tumor cells in vitro.
Pituitary Neoplasms
Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals.
Pituitary Neoplasms
Effects of vasoactive intestinal polypeptide (VIP) in human prolactin (PRL) secreting pituitary adenomas. Stimulation of PRL release and activation of adenylate cyclase.
Pituitary Neoplasms
Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation.
Pituitary Neoplasms
Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells.
Pituitary Neoplasms
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
Pituitary Neoplasms
Forskolin stimulates adenylate cyclase activity, cyclic AMP accumulation, and adrenocorticotropin secretion from mouse anterior pituitary tumor cells.
Pituitary Neoplasms
Ghrelin mRNA and GH secretagogue receptor mRNA in human GH-producing pituitary adenomas is affected by mutations in the alpha subunit of G protein.
Pituitary Neoplasms
Growth hormone releasing hormone-sensitive adenylate cyclase activity in growth hormone-producing pituitary adenoma: correlation to the response of plasma growth hormone to growth hormone releasing hormone in patients with acromegaly.
Pituitary Neoplasms
GS protein mutations and pituitary tumors: functional correlates and possible therapeutic implications.
Pituitary Neoplasms
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.
Pituitary Neoplasms
GTPase-inhibiting mutations activate the alpha-chain of Gs in human tumours.
Pituitary Neoplasms
Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. Preferential activation of protein kinase I by corticotropin releasing factor, isoproterenol, and forskolin.
Pituitary Neoplasms
Hormone-sensitive adenylate cyclase of prolactin-producing rat pituitary adenoma (GH4C1) cells: molecular organization.
Pituitary Neoplasms
Hydrolysis of GTP by the alpha-chain of Gs and other GTP binding proteins.
Pituitary Neoplasms
Hypothalamic hormones modulate G protein levels and second messenger responsiveness in GH3 rat pituitary tumour cells.
Pituitary Neoplasms
Hypothalamic peptides modulate cytosolic free Ca2+ levels and adenylyl cyclase activity in human nonfunctioning pituitary adenomas.
Pituitary Neoplasms
Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.
Pituitary Neoplasms
In vitro studies on TSH secretion and adenylate cyclase activity in a human TSH-secreting pituitary adenoma. Effects of somatostatin and dopamine.
Pituitary Neoplasms
Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element.
Pituitary Neoplasms
Inhibition of basal and corticotropin-releasing hormone-stimulated adenylate cyclase activity and cytosolic Ca2+ levels by somatostatin in human corticotropin-secreting pituitary adenomas.
Pituitary Neoplasms
Inhibition of GH1 rat pituitary tumor cell adenylyl cyclase activity by somatostatin.
Pituitary Neoplasms
Muscarinic cholinergic ligand binding to intact mouse pituitary tumor cells (AtT-20/D16-16) coupling with two biochemical effectors: adenylate cyclase and phosphatidylinositol turnover.
Pituitary Neoplasms
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Pituitary Neoplasms
Phorbol esters and thyroliberin have distinct actions regarding stimulation of prolactin secretion and activation of adenylate cyclase in rat pituitary tumour cells (GH4C1 cells).
Pituitary Neoplasms
Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas.
Pituitary Neoplasms
Resistance to somatostatin (SRIH) analog therapy in acromegaly. Re-evaluation of the correlation between the SRIH receptor status of the pituitary tumor and the in vivo inhibition of GH secretion in response to SRIH analog.
Pituitary Neoplasms
Somatostatin pretreatment desensitizes somatostatin receptors linked to adenylate cyclase and facilitates the stimulation of cyclic adenosine 3':5'-monophosphate accumulation in anterior pituitary tumor cells.
Pituitary Neoplasms
Somatostatin receptors on thyrotropin-secreting pituitary adenomas: comparison with the inhibitory effects of octreotide upon in vivo and in vitro hormonal secretions.
Pituitary Neoplasms
Spontaneous Intracellular Calcium Oscillations and G(s) ? Subunit Expression are Inversely Correlated with Secretory Granule Content in Pituitary Cells.
Pituitary Neoplasms
Stimulation of adrenocorticotropin secretion from AtT-20 cells by the calcium channel activator, BAY-K-8644, and its inhibition by somatostatin and carbachol.
Pituitary Neoplasms
The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells.
Pituitary Neoplasms
The thyroliberin receptor interacts directly with a stimulatory guanine-nucleotide-binding protein in the activation of adenylyl cyclase in GH3 rat pituitary tumour cells. Evidence obtained by the use of antisense RNA inhibition and immunoblocking of the stimulatory guanine-nucleotide-binding protein.
Pituitary Neoplasms
Thyroliberin receptor binding and adenylyl cyclase activation in cultured prolactin-producing rat pituitary tumor cells (GH cells).
Pituitary Neoplasms
Vasoactive intestinal peptide effects on GH3 pituitary tumor cells: high affinity binding, affinity labeling, and adenylate cyclase stimulation. Comparison with peptide histidine isoleucine and growth hormone-releasing factor.
Pituitary Neoplasms
[Vasoactive intestinal peptide (VIP): specific receptors and adenylate cyclase activation in a human prolactin-secreting pituitary tumor]
Plague
[Adenylate cyclase of the causative agent of plague: its purification and properties]
Plague
[Evaluation of the modulating action of Yersinia pestis adenylate cyclase on guinea pig peritoneal leukocytes using chemiluminescence]
Plague
[Role of histamine receptors of mouse and guinea pig peritoneal leukocytes in the pathogenetic effect of Yersinia pestis adenylate cyclase]
Plasmacytoma
Stimulation of chelators of the membrane bound adenylate cyclase in plasmacytoma cells.
Pneumonia, Viral
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
Polycystic Kidney Diseases
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Polycystic Kidney Diseases
Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease.
Polycystic Kidney Diseases
Generation and phenotypic characterization of Pde1a mutant mice.
Polycystic Kidney, Autosomal Dominant
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway.
Polycystic Kidney, Autosomal Dominant
Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells.
Polycystic Kidney, Autosomal Dominant
Generation and phenotypic characterization of Pde1a mutant mice.
Polycystic Kidney, Autosomal Dominant
KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro.
Polycystic Kidney, Autosomal Dominant
The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Recessive
Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells.
Polyuria
Lithium-induced polyuria: effect of lithium on adenylate cyclase and adenosine 3',5'-monophosphate phosphodiesterase in medullary ascending limb of Henle's loop and in medullary collecting tubules.
Polyuria
The relation between vasopressin stimulation of renal adenyl cyclase and lithium-induced polyuria in rats.
Pre-Eclampsia
Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Adenylate cyclase and guanylate cyclase activity in normal and leukemic human lymphocytes.
Premature Birth
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.
Primary Dysautonomias
Abnormal guanine nucleotide regulatory protein in MVP dysautonomia: evidence from reconstitution of Gs.
Prolactinoma
Combined effects of vasoactive intestinal peptide and dopamine on adenylate cyclase in prolactin-secreting cells.
Prolactinoma
Dopamine inhibits adenylate cyclase in human prolactin-secreting pituitary adenomas.
Prolactinoma
Expression of pituitary adenylate cyclase activating polypeptide and receptors in human brain tumors.
Prolactinoma
In vitro studies on prolactin release and adenylate cyclase activity in human prolactin-secreting pituitary adenomas. Different sensitivity of macro- and microadenomas to dopamine and vasoactive intestinal polypeptide.
Prolactinoma
Receptors for pituitary adenylate cyclase activating peptides in human pituitary adenomas.
Propionic Acidemia
Effects of methylmalonate and propionate on [3H]glutamate binding, adenylate cyclase activity and lipid synthesis in rat cerebral cortex.
Prostatic Neoplasms
?-arrestin2 mediates ?-2 adrenergic receptor signaling inducing prostate cancer cell progression.
Prostatic Neoplasms
Adenosine A(3) receptor suppresses prostate cancer metastasis by inhibiting NADPH oxidase activity.
Prostatic Neoplasms
Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action.
Prostatic Neoplasms
Distribution of Thyroliberin (TRH)- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-activated adenylyl cyclase in normal and neoplastic tissue with special reference to the prostate.
Prostatic Neoplasms
Inhibition of soluble adenylyl cyclase increases the radiosensitivity of prostate cancer cells.
Prostatic Neoplasms
Neurotensin enhances agonist-induced cAMP accumulation in PC3 cells via Ca2+ -dependent adenylyl cyclase(s).
Prostatic Neoplasms
Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells.
Prostatic Neoplasms
Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide stimulate interleukin-6 production in prostate cancer cells and prostatic epithelial cells.
Prostatic Neoplasms
[Proceedings: Experimental transplantable cancer and cyclic nucleotides. I. Adenyl cyclase activity and protein phosphorylating enzymes in transplantable prostatic cancer]
Proteinuria
Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria.
Pseudohypoparathyroidism
A case of Albright's hereditary osteodystrophy-like syndrome complicated by several endocrinopathies: normal Gs alpha gene and chromosome 2q37.
Pseudohypoparathyroidism
A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy.
Pseudohypoparathyroidism
A novel Gs alpha mutant in a patient with Albright hereditary osteodystrophy uncouples cell surface receptors from adenylyl cyclase.
Pseudohypoparathyroidism
Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds.
Pseudohypoparathyroidism
Altered activity of the nucleotide regulatory site in the parathyroid hormone-sensitive adenylate cyclase from the renal cortex of a patient with pseudohypoparathyroidism.
Pseudohypoparathyroidism
Characterization of Albright hereditary osteodystrophy and related disorders.
Pseudohypoparathyroidism
Clinical investigation of olfactory and auditory function in type I pseudohypoparathyroidism: participation of adenylate cyclase system.
Pseudohypoparathyroidism
Coupling defect of thyrotropin receptor and adenylate cyclase in a pseudohypoparathyroid patient.
Pseudohypoparathyroidism
Defective stimulation of adipocyte adenylate cyclase, blunted lipolysis, and obesity in pseudohypoparathyroidism 1a.
Pseudohypoparathyroidism
Deficient activity of receptor-cyclase coupling protein in platelets of patients with pseudohypoparathyroidism.
Pseudohypoparathyroidism
Deficient activity of receptor-cyclase coupling protein is transformed lymphoblasts of patients with pseudohypoparathyroidism, type I.
Pseudohypoparathyroidism
Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism.
Pseudohypoparathyroidism
Father to son transmission of decreased Ns activity in pseudohypoparathyroidism type Ia.
Pseudohypoparathyroidism
Fibroblast defect in pseudohypoparathyroidism, type I: reduced activity of receptor-cyclase coupling protein.
Pseudohypoparathyroidism
Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy.
Pseudohypoparathyroidism
Heterogeneous mutations in the gene encoding the alpha-subunit of the stimulatory G protein of adenylyl cyclase in Albright hereditary osteodystrophy.
Pseudohypoparathyroidism
Identification of a novel GNAS mutation for pseudohypoparathyroidism in a Chinese family.
Pseudohypoparathyroidism
Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis.
Pseudohypoparathyroidism
New form of pseudohypoparathyroidism with abnormal catalytic adenylate cyclase.
Pseudohypoparathyroidism
Olfactory dysfunction in type I pseudohypoparathyroidism: dissociation from Gs alpha protein deficiency.
Pseudohypoparathyroidism
Parathyroid hormone-sensitive adenyl cyclase from the renal cortex of a patient with pseudohypoparathyroidism.
Pseudohypoparathyroidism
Prevalence of three mutations in the Gs alpha gene among 24 families with pseudohypoparathyroidism type Ia.
Pseudohypoparathyroidism
Pseudohypoparathyroidism, a novel mutation in the betagamma-contact region of Gsalpha impairs receptor stimulation.
Pseudohypoparathyroidism
Pseudohypoparathyroidism: an inherited disorder of adenylate cyclase.
Pseudohypoparathyroidism
Pseudohypoparathyroidism: inheritance of deficient receptor-cyclase coupling activity.
Pseudohypoparathyroidism
Renal-resistant hormonoplethoric hypoparathyroidism with evidence for a defective response to cAMP.
Pseudohypoparathyroidism
Selective resistance to parathyroid hormone caused by a novel uncoupling mutation in the carboxyl terminus of G alpha(s). A cause of pseudohypoparathyroidism type Ib.
Pseudohypoparathyroidism
The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism.
Pseudohypoparathyroidism
The new bone biology: pathologic, molecular, and clinical correlates.
Pseudohypoparathyroidism
The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I.
Pseudohypoparathyroidism
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.
Pseudohypoparathyroidism
[Pseudohypoparathyroidism and the concept of hormonal resistance. Types Ia and Ic and pseudohypoparathyroidism]
Pseudohypoparathyroidism
[Pseudohypoparathyroidism and the concept of hormonal resistance. Types Ib and II]
Pseudohypoparathyroidism
[Pseudohypoparathyroidism: a generalized and multiple disorder in the adenyl cyclase system]
Pseudohypoparathyroidism
[The usefulness of the teriparatide acetate (Parathar) infusion test in the diagnosis of pseudohypoparathyroidism]
Pseudopseudohypoparathyroidism
Cutaneous ossification in Albright's hereditary osteodystrophy.
Psoriasis
Cyclosporin A induced augmentation of the beta-adrenergic adenylate cyclase response of pig epidermis.
Psoriasis
Decreased epidermal aryl hydrocarbon hydroxylase and localized pustular psoriasis.
Psoriasis
Electron microscopic cytochemical demonstration of adenyl cyclase activity in psoriatic epidermis.
Psoriasis
Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis.
Psoriasis
Neurotransmitters, neuropeptides and their receptors interact with immune response in healthy and psoriatic skin.
Psoriasis
Ultrastructural localization and differentiation of membrane-bound ATP utilizing enzymes including adenyl cyclase in normal and psoriatic epidermis.
Psoriasis
[Lack of beta-adrenergic stimulation of membrane bound adenyl cyclase in psoriasis as compared to normal epidermis (author's transl)]
Puberty, Precocious
Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function.
Pulmonary Disease, Chronic Obstructive
Identification of hub genes and functional modules in colon adenocarcinoma based on public databases by bioinformatics analysis.
Pulmonary Disease, Chronic Obstructive
Isoforskolin, an adenylyl cyclase activator, attenuates cigarette smoke-induced COPD in rats.
Pulmonary Disease, Chronic Obstructive
Stimulation of cyclic AMP production in human alveolar macrophages induced by inflammatory mediators and beta-sympathicomimetics.
Pulmonary Disease, Chronic Obstructive
The role of adenylyl cyclase isoform 6 in ?-adrenoceptor signalling in murine airways.
Pulmonary Fibrosis
Impairment in coupled beta-adrenergic receptor and adenylate cyclase system during bleomycin-induced lung fibrosis in hamsters.
Pyoderma
Adenylate cyclase activity of cultural strains of Neisseria gonorrhoeae and Staphylococcus aureus.
Rabies
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Rectal Neoplasms
Peculiarities of hormonal regulation of adenylate cyclase and lipid composition in colonic and rectal tumors.
Reflex, Abnormal
A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI).
Renal Insufficiency
Abnormality of adenylate cyclase regulation in human platelet membranes in renal insufficiency.
Renal Insufficiency
Adenylate cyclase activity and cAMP content of human platelets in uraemia.
Renal Insufficiency
Regulation of thrombocyte adenylate cyclase activity in terminal renal failure.
Renal Insufficiency
Surgically induced uremia in rats. II: Osseous PTH-susceptible signaling systems as predictors of bone resorption.
Renal Insufficiency
The role of testicular adenylate cyclase in the hypogonadism of renal insufficiency.
Renal Insufficiency, Chronic
Effects of dopamine on kidney function and on the adenyl cyclase phosphodiesterase system in man.
Reperfusion Injury
Elevated cyclic adenosine monophosphate ameliorates ischemia-reperfusion injury in rat cardiac allografts.
Reperfusion Injury
Role of cyclic nucleotides in ischemia and reperfusion injury of canine livers.
Reperfusion Injury
Role of H2O2 in changing beta-adrenoceptor and adenylyl cyclase in ischemia-reperfused hearts.
Respiratory Distress Syndrome
Adenosine 3',5'-monophosphate analogs and beta-adrenergic agonists induce the synthesis of the major surfactant apoprotein in human fetal lung in vitro.
Respiratory Insufficiency
cAMP-dependent reversal of opioid- and prostaglandin-mediated depression of the isolated respiratory network in newborn rats.
Respiratory Insufficiency
Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression.
Respiratory Insufficiency
Reversal by phosphodiesterase-4 blockers of in vitro apnea in the isolated brainstem-spinal cord preparation from newborn rats.
Respiratory Insufficiency
ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression.
Respiratory Tract Infections
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Respiratory Tract Infections
Viral pneumonia attenuates adenylate cyclase but not beta-adrenergic receptors in murine lung.
Retinal Degeneration
Degree of damage compensation by various PACAP treatments in monosodium glutamate-induced retinal degeneration.
Retinal Degeneration
Effects of pituitary adenylate cyclase activating polypeptide and its fragments on retinal degeneration induced by neonatal monosodium glutamate treatment.
Retinal Degeneration
Effects of pituitary adenylate cyclase activating polypeptide in retinal degeneration induced by monosodium-glutamate.
Retinal Degeneration
Neuroprotective Potential of Pituitary Adenylate Cyclase Activating Polypeptide in Retinal Degenerations of Metabolic Origin.
Retinal Degeneration
Pituitary Adenylate Cyclase Activating Polypeptide, A Potential Therapeutic Agent for Diabetic Retinopathy in Rats: Focus on the Vertical Information Processing Pathway.
Retinal Degeneration
Protective role of endogenous PACAP in inflammation-induced retinal degeneration.
Retinal Neovascularization
Beta-adrenoreceptor (?-AR) agonism influences retinal responses to hypoxia in a mouse model of retinopathy of prematurity.
Retinoblastoma
Coupling of corticotropin-releasing hormone receptors to adenylyl cyclase in human Y-79 retinoblastoma cells.
Retinoblastoma
Human Y-79 retinoblastoma cells express functional corticotropin-releasing hormone receptors.
Retinoblastoma
Novel high-affinity photoactivatable antagonists of corticotropin-releasing factor (CRF) photoaffinity labeling studies on CRF receptor, type 1 (CRFR1).
Retinoblastoma
On the mechanism of the cell cycle control of suspension-cultured tobacco cells after exposure to static magnetic field.
Rheumatic Diseases
Effect of gold compounds on the activity of adenylyl cyclase in human lymphocyte membranes.
Rhinitis, Allergic
[Experimental studies for botulinum toxin type A to antagonist the VIP/PACAP expression on nasal mucosa in allergic rhinitis rat].
Rhinitis, Allergic, Seasonal
[Comparison of fenoterol (Berotec) with the antiallergic benzopyrene compound PR-D 92 and a placebo in regard to the cutaneous immediate reaction in allergic patients (author's transl)]
Rhinitis, Atrophic
Adenylate cyclase activity of a 68,000-molecular-weight protein isolated from the outer membrane of Bordetella bronchiseptica.
Rubinstein-Taybi Syndrome
Interstitial 16p13.3 microduplication: case report and critical review of genotype-phenotype correlation.
Sarcoma
Adenylate cyclase activity in fibroblasts transformed by Kirsten or Moloney sarcoma viruses. Decreased activity and loss of response to prostaglandin E1.
Sarcoma
beta-Adrenergic receptors in pediatric tumors: uncoupled beta 1-adrenergic receptor in Ewing's sarcoma.
Sarcoma
Diverse expression of G-proteins in human sarcoma cell lines with different osteogenic potential: evidence for the involvement of Gi2 in cell proliferation.
Sarcoma
Increased adenylate cyclase activity in rat thyroid epithelial cells expressing viral ras genes.
Sarcoma
Isolation and characterization of two biologically active O-glycosylated forms of human parathyroid hormone produced in Saccharomyces cerevisiae. Identification of a new motif for O-glycosylation.
Sarcoma
Modulation of adenylate cyclase by guanine nucleotides and Kirsten sarcoma virus mediated transformation.
Sarcoma
Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma.
Sarcoma
Partial reversal of doxorubicin resistance by forskolin and 1,9-dideoxyforskolin in murine sarcoma S180 variants.
Sarcoma
ras oncogene-induced transformation of a rat seminal vesicle epithelial cell line produces a marked increase of adenylate cyclase and protein kinase C activities.
Sarcoma
Receptor-associated changes of the catecholamine-sensitive adenylate cyclase in glioma cells doubly transformed with Moloney sarcoma virus.
Sarcoma
Triiodothyronine stimulates steroid and VEGF production in murine Leydig cells via cAMP-PKA pathway.
Sarcoma 180
Small fragments from the A subunit of cholera toxin capable of activating adenylate cyclase.
Sarcoma, Avian
A comparison between adenylate cyclase solubilized from normal and Rous sarcoma virus-transformed chicken embryo fibroblasts.
Sarcoma, Avian
Adenylate cyclase activity and membrane polypeptides of chick embryo fibroblasts transformed with avian sarcoma viruses.
Sarcoma, Avian
Adenylate cyclase activity and the cAMP level are not directly correlated with transformation by avian sarcoma viruses.
Sarcoma, Avian
Adenylate cyclase activity is decreased in chick embryo fibroblasts transformed by wild type and temperature sensitive Schmidt-Ruppin Rous sarcoma virus.
Sarcoma, Avian
Adenylate cyclase and cyclic AMP phosphodiesterase of normal and Rous sarcoma virus transformed chicken embryo fibroblasts.
Sarcoma, Avian
Alterations in components of adenylate cyclase associated with transformation of chicken embryo fibroblasts by Rous sarcoma virus.
Sarcoma, Avian
Effect of membrane phospholipid composition changes on adenylate cyclase activity in normal and rous-sarcoma-transformed chicken embryo fibroblasts.
Sarcoma, Avian
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Sarcoma, Avian
Strain specificity of changes in adenylate cyclase activity in cells transformed by avian sarcoma viruses.
Sarcoma, Avian
The increase in hormone-stimulated adenylate cyclase activity following Rous sarcoma virus transformation.
Sarcoma, Avian
Transformation of chick-embryo fibroblasts by wild-type and temperature-sensitive Rous sarcoma virus alters adenylate cyclase activity.
Sarcoma, Ewing
Neuropeptide Y inhibits vasoactive intestinal peptide- and dopamine-induced cyclic AMP formation in human Ewing's sarcoma WE-68 cells.
Schistosomiasis
Granulomas in murine schistosomiasis mansoni contain vasoactive intestinal peptide-responsive lymphocytes.
Seizures
Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling.
Seizures
Early-life hyperthermic seizures upregulate adenosine A2A receptors in the cortex and promote depressive-like behavior in adult rats.
Seizures
Effect of interleukin-1beta on the variation of adenylyl cyclase expression in rats with seizures induced by L-glutamate.
Seizures
Effect of seizures kindled by subconvulsant doses of pentylenetetrazol on dopamine receptor binding and dopamine-sensitive adenylate cyclase in the rat.
Seizures
Ethological resolution of behavioral topography and D2-like vs. D1-like agonist responses in congenic D4 dopamine receptor "knockouts": identification of D4:D1-like interactions.
Seizures
Inhibition of adenylyl cyclase in amygdala blocks the effect of audiogenic seizure kindling in genetically epilepsy-prone rats.
Seizures
Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP.
Seizures
Microglia PACAP and glutamate: Friends or foes in seizure-induced autonomic dysfunction and SUDEP?
Seizures
Pharmacological inhibition of forskolin-stimulated adenylate cyclase activity in rat brain by melatonin, its analogs, and diazepam.
Seizures
Seizure-Induced Sympathoexcitation Is Caused by Activation of Glutamatergic Receptors in RVLM That Also Causes Proarrhythmogenic Changes Mediated by PACAP and Microglia in Rats.
Seizures
Selective regulation of recombinantly expressed mGlu7 metabotropic glutamate receptors by G protein-coupled receptor kinases and arrestins.
Seizures
SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled dopamine D1-like receptors: behavioural topography.
Sepsis
Alterations of G-protein and adenylate cyclase signaling in rat liver during the progression of sepsis.
Sepsis
Beta-adrenergic receptor-dependent and -independent stimulation of adenylate cyclase is impaired during severe sepsis in humans.
Sepsis
Cecal Ligation and Puncture Sepsis is Associated With Attenuated Expression of Adenylyl Cyclase 9 and Increased miR-142-3p.
Sepsis
G protein and adenylate cyclase complex-mediated signal transduction in the rat heart during sepsis.
Sepsis
Impairment of beta-adrenergic signaling in healthy peripheral blood mononuclear cells exposed to serum from patients with septic shock: involvement of the inhibitory pathway of adenylyl cyclase stimulation.
Sepsis
Impairment of cardiac beta-adrenoceptor cellular signaling by decreased expression of G(s alpha) in septic rabbits.
Sepsis
Sequential changes in autonomic regulation of cardiac myocytes after in vivo endotoxin injection in rat.
Sepsis
[A study on the mechanism of the cardiac adenylyl cyclase activity alteration in septic rats]
Shock, Septic
Anti-shock effect of pituitary adenylate cyclase activating polypeptide (PACAP) on experimental endotoxin shock in dogs.
Shock, Septic
Desensitization of rat cardiomyocyte adenylyl cyclase stimulation by plasma of noradrenaline-treated patients with septic shock.
Shock, Septic
Impairment of beta-adrenergic signaling in healthy peripheral blood mononuclear cells exposed to serum from patients with septic shock: involvement of the inhibitory pathway of adenylyl cyclase stimulation.
Shock, Septic
Myocardial beta adrenergic receptor coupling to adenylate cyclase during developing septic shock.
Shock, Septic
Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock.
Shock, Septic
Unexpected hyperactivity of myocardial adenylate cyclase system in endotoxic male rats.
Skin Diseases
Abnormalities in adenyl cyclase in psoriasis, a hyperproliferative skin disease.
Skin Diseases
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.
Skin Diseases
[Contemporary views of role played by neuro-humoral and adenylate cyclase systems in occupational allergic skin diseases (review of literature)]
Skin Neoplasms
Regulation of human melanocortin 1 receptor signaling and trafficking by Thr-308 and Ser-316 and its alteration in variant alleles associated with red hair and skin cancer.
Skin Neoplasms
Role of G protein-coupled receptor kinases in the homologous desensitization of the human and mouse melanocortin 1 receptors.
Sleep Deprivation
Sleep deprivation increases dopamine D1 receptor antagonist [3H]SCH 23390 binding and dopamine-stimulated adenylate cyclase in the rat limbic system.
Sleep Deprivation
Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements.
Small Cell Lung Carcinoma
Pituitary adenylate cyclase activating peptide receptors regulate the growth of non-small cell lung cancer cells.
Small Cell Lung Carcinoma
Pituitary adenylate cyclase activating polypeptide receptors are present on small cell lung cancer cells.
Smooth Muscle Tumor
Characteristics of an adenylate cyclase coupled beta 2-adrenergic receptor in a smooth muscle tumor cell line.
Spastic Paraplegia, Hereditary
The genetic etiology in cerebral palsy mimics: The results from a Greek tertiary care center.
Spinal Cord Injuries
(284) Persistent electrical activity in primary nociceptors after spinal cord injury is maintained by scaffolded adenylyl cyclase and protein kinase A and is associated with altered adenylyl cyclase regulation.
Spinal Cord Injuries
A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI).
Spinal Cord Injuries
Changes in pituitary adenylate cyclase activating polypeptide expression in urinary bladder pathways after spinal cord injury.
Spinal Cord Injuries
Effects of intrathecal administration of pituitary adenylate cyclase activating polypeptide on lower urinary tract functions in rats with intact or transected spinal cords.
Spinal Cord Injuries
Lack of adenylate cyclase 1 (AC1): consequences on corticospinal tract development and on locomotor recovery after spinal cord injury.
Spinal Cord Injuries
Meglumine cyclic adenylate improves neurological function following acute spinal cord injury in rats.
Spinal Cord Injuries
Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury.
Spinal Cord Injuries
Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.
Spinal Cord Injuries
Pituitary adenylate cyclase activating polypeptide in the retina: focus on the retinoprotective effects.
Starvation
A novel Myb homolog initiates Dictyostelium development by induction of adenylyl cyclase expression.
Starvation
A possible involvement of cya gene in the synthesis of cyclic guanosine 3':5'-monophosphate in E. coli.
Starvation
Adenylate cyclase and phosphodiesterase in the rat gastric mucosa after starvation, feeding and pentagastrin.
Starvation
amiB, a novel gene required for the growth/differentiation transition in Dictyostelium.
Starvation
Changed sensitivity of adenylate cyclase signaling system to biogenic amines and peptide hormones in tissues of starving rats.
Starvation
Desynchronization of cells on the developmental path triggers the formation of spiral waves of cAMP during Dictyostelium aggregation.
Starvation
Developmentally regulated compartmentalization of adenylate cyclase in Dictyostelium discoideum.
Starvation
Dictyostelium TRFA homologous to yeast Ssn6 is required for normal growth and early development.
Starvation
Effects of starvation, refeeding, and fat feeding on adipocyte ghost adenyl cyclase activity.
Starvation
Genetic regulation of differentiation towards meiosis in the yeast Saccharomyces cerevisiae.
Starvation
In vitro metacyclogenesis of Trypanosoma cruzi induced by starvation correlates with a transient adenylyl cyclase stimulation as well as with a constitutive upregulation of adenylyl cyclase expression.
Starvation
Increased sensitivity to epinephrine stimulated lipolysis during starvation: tighter coupling of the adenylate cyclase complex.
Starvation
Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A.
Starvation
Modulation of expression of the stress-inducible p118 of Saccharomyces cerevisiae by cAMP. II. A study of p118 expression in mutants of the cAMP cascade.
Starvation
Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity.
Starvation
Regulation of two phosphatases and a cyclic phosphodiesterase of Salmonella typhimurium.
Starvation
Sir2D, a Sirtuin family protein, regulates adenylate cyclase A expression through interaction with the MybB transcription factor early in Dictyostelium development upon starvation.
Starvation
Starvation-induced increase in the parathyroid hormone/PTH-related protein receptor mRNA of bone and kidney in sham-operated and thyroparathyroidectomized rats.
Starvation
The ste13+ gene encoding a putative RNA helicase is essential for nitrogen starvation-induced G1 arrest and initiation of sexual development in the fission yeast Schizosaccharomyces pombe.
Starvation
[Reactivity of the adenylyl cyclase system in rat tissues to biogenic amines and peptide hormones under starvation condition]
Stomach Neoplasms
Desensitization by histamine of H2 receptor-mediated adenylate cyclase activation in the human gastric cancer cell line HGT-1.
Stomach Neoplasms
Protein kinase C alpha is the isoform responsible for inhibition of histamine H2 receptor mediated stimulation of adenylate cyclase in the human gastric cancer cell line HGT-1.
Stomach Neoplasms
Protein kinase C and adenylate cyclase as targets for growth inhibition of human gastric cancer cells.
Stomach Neoplasms
Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.
Stomach Neoplasms
The alpha isoform of protein kinase C inhibits histamine-stimulated adenylate cyclase activity in a particulate fraction of the human gastric cancer cell line HGT-1.
Stomach Ulcer
[The effect of laser therapy on the mechanisms for generating healing in long-term nonhealing stomach ulcers]
Stroke
Effect of lipopolysaccharide on the transport of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier.
Stroke
Modulation of ischemic-induced damage to cerebral adenylate cyclase in gerbils by calcium channel blockers.
Stroke
Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.
Stroke
Multimodal Neuroprotection Induced by PACAP38 in Oxygen-Glucose Deprivation and Middle Cerebral Artery Occlusion Stroke Models.
Stroke
Regional cyclic AMP systems during secondary ischemia in gerbils: influence of anesthetic agents.
Stroke
Stability of the beta-adrenergic receptor/adenylyl cyclase pathway of pediatric myocardium after brain death.
Stroke
Study design of Dal-GenE, a pharmacogenetic trial targeting reduction of cardiovascular events with dalcetrapib.
Subarachnoid Hemorrhage
The effect of subarachnoid hemorrhage on mechanisms of vasodilation mediated by cyclic adenosine monophosphate.
Sunburn
Effects of UVB irradiation on epidermal adenylate cyclase responses in vitro: its relation to sunburn cell formation.
Supranuclear Palsy, Progressive
Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
Syncope
Diagnosis and prevention of the vasodepressor type of neurally mediated syncope in Japanese patients.
Syncope
Neurally mediated syncope diagnosis based on adenylate cyclase activity in Japanese patients.
Synovitis
The adenylate cyclase of rheumatoid synovial fluid macrophages is more sensitive for dl-5E, 19,14-di dehydro-carbo-prostacyclin, a stable prostacyclin analogue, than for prostaglandin E2.
Tachycardia
Activation of the hyperpolarization-activated current (if) in sino-atrial node myocytes of the rabbit by vasoactive intestinal peptide.
Tachycardia
Influence of a phosphodiesterase inhibitor on the chronotropic effects of glucagon and norepinephrine in fetal mouse hearts.
Tachycardia
Milrinone inhibits sympathetic-mediated tachycardia by a postjunctional action independent of cyclic AMP.
Tachycardia
Reduced adenylyl cyclase inhibition by carbachol and GTP during acute myocardial ischaemia.
Tachycardia
Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects.
Tachycardia
Specific M2-receptor activation: an alternative to treatment with beta-receptor blockers?
Tachycardia
The cellular basis for the blunted response to beta-adrenergic stimulation in supraventricular tachycardia-induced cardiomyopathy.
Tachycardia, Supraventricular
Cellular and molecular alterations in the beta adrenergic system with cardiomyopathy induced by tachycardia.
Tardive Dyskinesia
Effects of ceruletide on perioral movements and the dopamine receptor-adenylate cyclase system in rats chronically treated with fluphenazine.
Tardive Dyskinesia
Rolipram, a selective c-AMP phosphodiesterase inhibitor suppresses oro-facial dyskinetic movements in rats.
Tauopathies
Hyperphosphorylated Tau, Increased Adenylate Cyclase 5 (ADCY5) Immunoreactivity, but No Neuronal Loss in ADCY5-Dyskinesia.
Teratocarcinoma
Different expression of adenylyl cyclase isoforms after retinoic acid induction of P19 teratocarcinoma cells.
Teratocarcinoma
Differentiation of F9 teratocarcinoma stem cells to primitive endoderm is regulated by the Gialpha2/Gsalpha axis via phospholipase C and not adenylylcyclase.
Tetanus
Structural Biology and Molecular Modeling to Analyze the Entry of Bacterial Toxins and Virulence Factors into Host Cells.
Thrombosis
Diminished platelet adenylate cyclase activation by prostaglandin D2 in acute thrombosis.
Thrombosis
Shear-dependent suppression of platelet thrombus formation by phosphodiesterase 3 inhibition requires low levels of concomitant Gs-coupled receptor stimulation.
Thymoma
Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity.
Thymoma
Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling.
Thymoma
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.
Thymoma
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
Thyroid Cancer, Papillary
Growth suppression of thyroid cancer cells by adenylcyclase activator.
Thyroid Carcinoma, Anaplastic
Growth suppression of thyroid cancer cells by adenylcyclase activator.
Thyroid Diseases
Graves' IgG stimulation of iodide uptake in FRTL-5 rat thyroid cells: a clinical assay complementing FRTL-5 assays measuring adenylate cyclase and growth-stimulating antibodies in autoimmune thyroid disease.
Thyroid Diseases
Histochemical and biochemical study on adenylate cyclase and 5'-nucleotidase activity in thyroid glands with normal and various thyroid diseases.
Thyroid Diseases
[Studies on the thyrotropin receptor and adenylate cyclase activity in various thyroid diseases: I. The properties of TSH receptor and adenylate cyclase in Graves' thyroid and retro-orbital adipose tissues (author's transl)]
Thyroid Diseases
[Studies on the thyrotropin receptor and adenylate cyclase activity in various thyroid diseases: II. The properties of TSH receptor and adenylate cyclase in human thyroid tumors (author's transl)]
Thyroid Neoplasms
Activating mutations of the TSH receptor in differentiated thyroid carcinomas.
Thyroid Neoplasms
Adenyl cyclase activity in human thyroid plasma membranes from normal human thyroid tissue and thyroid adenomas.
Thyroid Neoplasms
An in vitro model of thyroid neoplasia: permanently transfected FRTL-5 cells with thyroglobulin promoter-cholera toxin A1 subunit minigene.
Thyroid Neoplasms
Dissociation in the response of the adenylate cyclase system to thyrotropin and prostaglandin E2 in human thyroid carcinoma tissue.
Thyroid Neoplasms
Effects of sorafenib and an adenylyl cyclase activator on in vitro growth of well-differentiated thyroid cancer cells.
Thyroid Neoplasms
Expression of functional stimulatory guanine nucleotide binding protein in nonfunctioning thyroid adenomas is not correlated to adenylate cyclase activity and growth of these tumors.
Thyroid Neoplasms
Growth inhibition of new human thyroid carcinoma cell lines by activation of adenylate cyclase through the beta-adrenergic receptor.
Thyroid Neoplasms
Human thyroid cancer: membrane thyrotropin binding and adenylate cyclase activity.
Thyroid Neoplasms
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
Thyroid Neoplasms
T.S.H. receptor and adenylate cyclase in undifferentiated thyroid carcinoma.
Thyroid Neoplasms
Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue.
Thyroid Neoplasms
Thyrotrophin stimulation of adenylate cyclase and iodine uptake in human differentiated thyroid cancer.
Thyroid Neoplasms
Thyrotropin (TSH) receptor and adenylate cyclase activity in human thyroid tumors: absence of high affinity receptor and loss of TSH responsiveness in undifferentiated thyroid carcinoma.
Thyroid Neoplasms
Thyrotropin binding and adenylate cyclase activation in normal and neoplastic human thyroid tissue: lack of effect of thyroglobulin.
Thyroid Neoplasms
Thyrotropin binding and adenylate cyclase stimulation in thyroid neoplasms.
Thyroid Neoplasms
Thyrotropin receptor-adenylate cyclase function in human thyroid neoplasms.
Thyroid Neoplasms
Thyrotropin regulation of adenylate cyclase activity in human thyroid neoplasms.
Thyroid Neoplasms
TSH binding correlates with TSH-stimulated thyroid adenylate cyclase activity in human thyroid tissues.
Thyroid Neoplasms
[Growth and invasion of differentiated thyroid gland carcinoma: importance of signal transduction]
Thyroid Neoplasms
[Stimulation of adenyl cyclase and fixation of iodine in human cancerous thyroid cells in culture]
Thyroid Nodule
Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of "cold" thyroid nodules and normal human thyroid tissue.
Thyroid Nodule
Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules.
Thyroid Nodule
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Thyroid Nodule
[Comparison of the effect of TSH and fluoride on the adenylate cyclase activity of cold thyroid nodules (author's transl)]
Thyroiditis
Prostacyclin stimulation of adenylate cyclase activity in human thyroid membranes.
Thyroiditis
Thyroid-stimulating immunoglobulins in Hashimoto's thyroiditis measured by radioreceptor assay and adenylate cyclase stimulation and their relationship to HLA-D alleles.
Tonsillitis
[Enzyme histochemical characteristics of prostaglandin synthetase, adenylate cyclase and cAMP in a focus of inflammation in chronic tonsillitis]
Toxemia
Synthesis of ?-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
Toxemia
Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.
Tremor
Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma.
Tremor
Protein interaction studies for understanding the tremor pathway in Parkinson's disease.
Tuberculosis
A structural basis for the role of nucleotide specifying residues in regulating the oligomerization of the Rv1625c adenylyl cyclase from M. tuberculosis.
Tuberculosis
Adenylyl cyclase inMycobacterium tuberculosis H37Rv-A possible virulence factor.
Tuberculosis
Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection.
Tuberculosis
Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis has an autoinhibitory N-terminal domain.
Tuberculosis
Adenylyl cyclase Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases.
Tuberculosis
An adenylyl cyclase pseudogene in Mycobacterium tuberculosis has a functional ortholog in Mycobacterium avium.
Tuberculosis
Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase.
Tuberculosis
BCG constitutively expressing the adenylyl cyclase encoded by Rv2212 increases its immunogenicity and reduces replication of M. tuberculosis in lungs of BALB/c mice.
Tuberculosis
Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264.
Tuberculosis
Characterization of phylogenetically distant members of the adenylate cyclase family from mycobacteria: Rv1647 from Mycobacterium tuberculosis and its orthologue ML1399 from M. leprae.
Tuberculosis
Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling.
Tuberculosis
Comparison of the in vivo & in vitro activities of adenylate cyclase from Mycobacterium tuberculosis H37Ra (NCTC 7417).
Tuberculosis
Cyclic AMP in mycobacteria: characterization and functional role of the Rv1647 ortholog in Mycobacterium smegmatis.
Tuberculosis
Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase.
Tuberculosis
Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids.
Tuberculosis
Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.
Tuberculosis
Eukaryotic-like adenylyl cyclases in Mycobacterium tuberculosis H37Rv: cloning and characterization.
Tuberculosis
Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv.
Tuberculosis
Functional chimeras between the catalytic domains of the mycobacterial adenylyl cyclase Rv1625c and a Paramecium guanylyl cyclase.
Tuberculosis
Induction of cytotoxic T lymphocyte response against Mycobacterial antigen using domain I of anthrax edema factor as antigen delivery system.
Tuberculosis
Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.
Tuberculosis
Interaction of RvErp protein of Mycobacterium tuberculosis with Rv2212 enhances intracellular survival of Mycobacterium smegmatis.
Tuberculosis
Mutational analysis of the Mycobacterium tuberculosis Rv1625c adenylyl cyclase: residues that confer nucleotide specificity contribute to dimerization.
Tuberculosis
Origin of asymmetry in adenylyl cyclases: structures of Mycobacterium tuberculosis Rv1900c.
Tuberculosis
Overexpression of Adenylyl Cyclase Encoded by the Mycobacterium tuberculosis Rv2212 Gene Confers Improved Fitness, Accelerated Recovery from Dormancy and Enhanced Virulence in Mice.
Tuberculosis
Polyphosphates from Mycobacterium bovis--potent inhibitors of class III adenylate cyclases.
Tuberculosis
Purification, crystallization and preliminary X-ray diffraction analysis of the catalytic domain of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis.
Tuberculosis
Search for genes potentially involved in Mycobacterium tuberculosis virulence by mRNA differential display.
Tuberculosis
Stimulation of mammalian G-protein-responsive adenylyl cyclases by carbon dioxide.
Tuberculosis
The effect of HAMP domains on class IIIb adenylyl cyclases from Mycobacterium tuberculosis.
Tuberculosis
The structure of the regulatory domain of the adenylyl cyclase Rv1264 from Mycobacterium tuberculosis with bound oleic acid.
Tuberculosis
Transmembrane signaling in chimeras of the Escherichia coli aspartate and serine chemotaxis receptors and bacterial class III adenylyl cyclases.
Tuberculosis
[Changes in the properties of adenylate cyclase from guinea pig lungs in tuberculosis]
Tuberculosis, Bovine
Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis.
Uremia
Effects of uremia, acetate and bicarbonate dialysis on beta-adrenergic responsiveness as assessed by epinephrine-stimulated adenylate cyclase.
Uremia
Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration.
Uremia
The regulation of skeletal muscle alanine and glutamine formation and release in experimental chronic uremia in the rat: subsensitivity of adenylate cyclase and amino acid release to epinephrine and serotonin.
Urinary Bladder Neoplasms
Differences in adenylate cyclase activities in murine normal cells and bladder tumor cells in tissue culture.
Urinary Incontinence
Role of vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide in the vaginal wall of women with stress urinary incontinence and pelvic organ prolapse.
Uterine Cervical Neoplasms
Different effects of adenylyl cyclase activators and phosphodiesterases inhibitors on cervical cancer (HeLa) and breast cancer (MCF-7) cells proliferation.
Uterine Cervical Neoplasms
GTL001 and bivalent CyaA-based therapeutic vaccine strategies against human papillomavirus and other tumor-associated antigens induce effector and memory T-cell responses that inhibit tumor growth.
Uterine Cervical Neoplasms
miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells.
Uterine Cervical Neoplasms
The role of ADCYAP1, adenylate cyclase activating polypeptide 1, as a methylation biomarker for the early detection of cervical cancer.
Vaccinia
Functional characterization of the human dopamine D4.2 receptor using vaccinia virus as an expression system.
Vaccinia
Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara.
Vascular Diseases
Thyrotropin regulation of cyclic adenosine monophosphate production in human coronary artery smooth muscle cells.
Ventricular Dysfunction
Pharmacokinetics and a simulation model of colforsin daropate, new forskolin derivative inotropic vasodilator, in patients undergoing coronary artery bypass grafting.
Ventricular Dysfunction, Left
Functional activity and expression of the myocardial postreceptor adenylyl cyclase system in pressure overload hypertrophy in rat.
Ventricular Fibrillation
Alterations in beta-adrenergic receptors, adenylate cyclase, and cyclic AMP concentrations during acute myocardial ischemia and reperfusion.
Ventricular Fibrillation
Contrasting effects of cyclic AMP increase caused by beta-adrenergic stimulation or by adenylate cyclase activation on ventricular fibrillation threshold of isolated rat heart.
Ventricular Fibrillation
Effect of interventions that increase cyclic AMP levels on susceptibility to ventricular fibrillation in unanesthetized dogs.
Ventricular Fibrillation
Inhibition by simulated ischemia or hypoxia of delayed afterdepolarizations provoked by cyclic AMP: significance for ischemic and reperfusion arrhythmias.
Ventricular Fibrillation
[Proceedings: Myocardial adenyl cyclase (5). Effects of propranolol on the ventricular fibrillation threshold in acute myocardial ischemia and the myocardial adenyl cyclase system]
Vesicular Stomatitis
Cyclic AMP modulates the rate of 'constitutive' exocytosis of apical membrane proteins in Madin-Darby canine kidney cells.
Virus Diseases
Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs.
Virus Diseases
Inhibition of opiate receptor-mediated signal transmission by rabies virus in persistently infected NG-108-15 mouse neuroblastoma-rat glioma hybrid cells.
Vitamin A Deficiency
A vitamin A-free diet results in impairment of the rat hippocampal somatostatinergic system.
Vitamin B 12 Deficiency
Impairment of adenylyl cyclase signal transduction in mecobalamin-deficient rats.
Vitamin B 12 Deficiency
Vitamin B12 deficiency results in the abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlated with impairment of the adenylyl cyclase system in rat liver.
Vitamin D Deficiency
Impaired production and decreased urinary excretion of adenosine 3',5'-monophosphate in primary hyperparathyroidism with vitamin D deficiency.
Vitamin D Deficiency
Parathyroid function in different stages of vitamin D deficiency rickets.
Vitamin E Deficiency
Vitamin E deficiency impairs the somatostatinergic receptor-effector system and leads to phosphotyrosine phosphatase overactivation and cell death in the rat hippocampus.
Whooping Cough
26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas.
Whooping Cough
5-HT1A receptor-mediated inhibition of acetylcholine release from guinea pig myenteric plexus: potential mechanisms.
Whooping Cough
5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus.
Whooping Cough
5-Hydroxytryptamine1A receptors are linked to a Gi-adenylate cyclase complex in rat hippocampus.
Whooping Cough
5-Hydroxytryptamine2A receptors expressed in rat renal mesangial cells inhibit cyclic AMP accumulation.
Whooping Cough
A 23-kilodalton protein, distinct from BvgA, expressed by virulent Bordetella pertussis binds to the promoter region of vir-regulated toxin genes.
Whooping Cough
A Bacterial Adenylate Cyclase-Based Two-Hybrid System Compatible with Gateway® Cloning.
Whooping Cough
A bacterial two-hybrid system based on a reconstituted signal transduction pathway.
Whooping Cough
A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor.
Whooping Cough
A Bordetella pertussis acellular vaccine candidate: antigenic characterization and antibody induction.
Whooping Cough
A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells.
Whooping Cough
A cysteine-3 to serine mutation of the G-protein Gi1 alpha abrogates functional activation by the alpha 2A-adrenoceptor but not interactions with the beta gamma complex.
Whooping Cough
A direct pyrophosphatase-coupled assay provides new insights into the activation of the secreted adenylate cyclase from Bordetella pertussis by calmodulin.
Whooping Cough
A dual role of protein kinase C in insulin signal transduction via adenylyl cyclase signaling system in muscle tissues of vertebrates and invertebrates.
Whooping Cough
A Gateway(®) -compatible bacterial adenylate cyclase-based two-hybrid system.
Whooping Cough
A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line.
Whooping Cough
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Whooping Cough
A kinase-mediated regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): disparate response sensitivities of distinct IGFBP species.
Whooping Cough
A molecularly identified P2Y receptor simultaneously activates phospholipase C and inhibits adenylyl cyclase and is nonselectively activated by all nucleoside triphosphates.
Whooping Cough
A monoclonal antibody directed against the catalytic site of Bacillus anthracis adenylyl cyclase identifies a novel mammalian brain catalytic subunit.
Whooping Cough
A neuroactive steroid inhibits guinea pig airway sensory nerves via Maxi-K channel activation.
Whooping Cough
A new assay for the invasive adenylate cyclase toxin of Bordetella pertussis based on its morphological effects on the fibronectin-stimulated spreading of BHK21 cells.
Whooping Cough
A novel hypothalamic peptide, pituitary adenylate cyclase activating peptide, modulates Sertoli cell function in vitro.
Whooping Cough
A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases: crossover from G protein-coupled inhibition to stimulation.
Whooping Cough
A novel mechanism of action of corticotropin releasing factor in rat Leydig cells.
Whooping Cough
A novel signaling pathway for beta-adrenergic receptor-mediated activation of phosphoinositide 3-kinase in H9c2 cardiomyocytes.
Whooping Cough
A pharmacological investigation of the contribution of muscarinic receptor-linked potassium channels to the reversal by carbachol of positive inotropic responses of rabbit left atrium to cyclic AMP-generating agents.
Whooping Cough
A phase variant of Bordetella pertussis with a mutation in a new locus involved in the regulation of pertussis toxin and adenylate cyclase toxin expression.
Whooping Cough
A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers.
Whooping Cough
A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.
Whooping Cough
A simple method for the assay of Bordetella pertussis adenylate cyclase employing 31P nuclear magnetic resonance spectroscopy.
Whooping Cough
A two-dimensional model of cell movement. Well differentiated human rectal adenocarcinoma cells move as coherent sheets upon TPA stimulation.
Whooping Cough
A1 adenosine receptors expressed in CHO-cells couple to adenylyl cyclase and to phospholipase C.
Whooping Cough
A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig.
Whooping Cough
A3 adenosine receptors in human astrocytoma cells: agonist-mediated desensitization, internalization, and down-regulation.
Whooping Cough
Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: characterization of a wild D2L receptor coupled to native transduction mechanisms.
Whooping Cough
Acceleration of desipramine-induced changes on the dopamine receptor-coupled adenylate cyclase system by pertussis toxin.
Whooping Cough
Accounting for ligand-bound metal ions in docking small molecules on adenylyl cyclase toxins.
Whooping Cough
Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon.
Whooping Cough
Actions of cyclic adenosine monophosphate on the cytodifferentiation of ovarian cells: studies in cultured swine granulosa cells using a novel exogenous adenylate cyclase from Bordetella pertussis.
Whooping Cough
Actions of pertussis toxin on the inhibitory effects of dopamine and somatostatin on prolactin and growth hormone release from ovine anterior pituitary cells.
Whooping Cough
Activation by thiol of the latent NAD glycohydrolase and ADP-ribosyltransferase activities of Bordetella pertussis toxin (islet-activating protein).
Whooping Cough
Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis.
Whooping Cough
Activation of a pertussis toxin-sensitive, inhibitory G-protein is necessary for steroid-mediated oocyte maturation in spotted seatrout.
Whooping Cough
Activation of Bordetella pertussis adenylate cyclase by the carboxyl-terminal tryptic fragment of calmodulin.
Whooping Cough
Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation.
Whooping Cough
Activation of Gi protein by peptide structures of the muscarinic M2 receptor second intracellular loop.
Whooping Cough
Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation.
Whooping Cough
Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis.
Whooping Cough
Activation of opioid and muscarinic receptors stimulates basal adenylyl cyclase but inhibits Ca2+/calmodulin- and forskolin-stimulated enzyme activities in rat olfactory bulb.
Whooping Cough
Activation of protein kinase C by oxytocin inhibits the biological activity of the human myometrial corticotropin-releasing hormone receptor at term.
Whooping Cough
Activation of the cloned human kappa opioid receptor by agonists enhances [35S]GTPgammaS binding to membranes: determination of potencies and efficacies of ligands.
Whooping Cough
Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.
Whooping Cough
Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: coupling to multiple G proteins.
Whooping Cough
Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells.
Whooping Cough
Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.
Whooping Cough
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases.
Whooping Cough
Acylation of lysine 983 is sufficient for toxin activity of Bordetella pertussis adenylate cyclase. Substitutions of alanine 140 modulate acylation site selectivity of the toxin acyltransferase CyaC.
Whooping Cough
Acyltransferase-mediated selection of the length of the fatty acyl chain and of the acylation site governs activation of bacterial RTX toxins.
Whooping Cough
Adaptations of myocardial beta-adrenergic receptor complex in hibernating marmots.
Whooping Cough
Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations.
Whooping Cough
Adaptive responses of human monocytes infected by bordetella pertussis: the role of adenylate cyclase hemolysin.
Whooping Cough
Adenosine 3':5'-cyclic monophosphate (cAMP) is not the mediator of kappa opiate effect on human placental lactogen release.
Whooping Cough
Adenosine A1 receptor-dependent and -independent effects of the allosteric enhancer PD 81,723.
Whooping Cough
Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells.
Whooping Cough
Adenosine and muscarinic cholinergic receptors attenuate cyclic AMP accumulation by different mechanisms in 1321N1 astrocytoma cells.
Whooping Cough
Adenosine and related compounds counteract tumor necrosis factor-alpha inhibition of neutrophil migration: implication of a novel cyclic AMP-independent action on the cell surface.
Whooping Cough
Adenosine-sensitive afterdepolarizations and triggered activity in guinea pig ventricular myocytes.
Whooping Cough
Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells.
Whooping Cough
Adenylate cyclase activity during phenotypic variation of Bordetella pertussis.
Whooping Cough
Adenylate cyclase activity of Bordetella organisms. I. Its production in liquid medium.
Whooping Cough
Adenylate cyclase activity of v-ras-k transformed rat epithelial thyroid cells.
Whooping Cough
Adenylate cyclase influences filamentous haemagglutinin-mediated attachment of Bordetella pertussis to epithelial alveolar cells.
Whooping Cough
Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis.
Whooping Cough
Adenylate cyclase toxin (CyaA) of Bordetella pertussis. Evidence for the formation of small ion-permeable channels and comparison with HlyA of Escherichia coli.
Whooping Cough
Adenylate cyclase toxin from Bordetella pertussis enhances cisplatin-induced apoptosis to lung cancer cells in vitro.
Whooping Cough
Adenylate cyclase toxin from Bordetella pertussis produces ion conductance across artificial lipid bilayers in a calcium- and polarity-dependent manner.
Whooping Cough
Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.
Whooping Cough
Adenylate cyclase toxin from Bordetella pertussis. Conformational change associated with toxin activity.
Whooping Cough
Adenylate cyclase toxin from Bordetella pertussis. Identification and purification of the holotoxin molecule.
Whooping Cough
Adenylate cyclase toxin from Bordetella pertussis. The relationship between induction of cAMP and hemolysis.
Whooping Cough
Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions.
Whooping Cough
Adenylate cyclase toxin is critical for colonization and pertussis toxin is critical for lethal infection by Bordetella pertussis in infant mice.
Whooping Cough
Adenylate cyclase toxin of Bordetella pertussis: production, purification, and partial characterization.
Whooping Cough
Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells.
Whooping Cough
Adenylate cyclase toxin promotes internalisation of integrins and raft components and decreases macrophage adhesion capacity.
Whooping Cough
Adenylate cyclase toxin-mediated delivery of the S1 subunit of pertussis toxin into mammalian cells.
Whooping Cough
Adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis. Different processes for interaction with and entry into target cells.
Whooping Cough
Adenylyl cyclase interaction with the D2 dopamine receptor family; differential coupling to Gi, Gz, and Gs.
Whooping Cough
Adjuvant action of cholera toxin and pertussis toxin in the induction of IgA antibody response to orally administered antigen.
Whooping Cough
Adjuvant and protective properties of native and recombinant Bordetella pertussis adenylate cyclase toxin preparations in mice.
Whooping Cough
Adjuvant effects of adenylate cyclase toxin of Bordetella pertussis after intranasal immunisation of mice.
Whooping Cough
Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigens.
Whooping Cough
ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells.
Whooping Cough
ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.
Whooping Cough
ADP-ribosylation of adenylate cyclase by pertussis toxin. Effects on inhibitory agonist binding.
Whooping Cough
ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.
Whooping Cough
Adrenergic agonists induce heterologous sensitization of adenylate cyclase in NS20Y-D(2L) cells.
Whooping Cough
Adrenergic control of cAMP generation in rat inner medullary collecting tubule cells.
Whooping Cough
Adrenergic receptor-mediated regulation of cultured rabbit airway smooth muscle cell proliferation.
Whooping Cough
Affinity-based chromatography utilizing genetically engineered proteins. Interaction of Bordetella pertussis adenylate cyclase with calmodulin.
Whooping Cough
Age increases cardiac Galpha(i2) expression, resulting in enhanced coupling to G protein-coupled receptors.
Whooping Cough
Age-related and testicular regression-induced changes in adenosine 3',5'-monophosphate responses in cultured hamster Sertoli cells.
Whooping Cough
Agonist occupation of an alpha2A-adrenoreceptor-Gi1alpha fusion protein results in activation of both receptor-linked and endogenous Gi proteins. Comparisons of their contributions to GTPase activity and signal transduction and analysis of receptor-G protein activation stoichiometry.
Whooping Cough
Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation.
Whooping Cough
Agonist-induced desensitization of D2 dopamine receptors in human Y-79 retinoblastoma cells.
Whooping Cough
Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin.
Whooping Cough
Agonist-specific coupling of a cloned Drosophila melanogaster D1-like dopamine receptor to multiple second messenger pathways by synthetic agonists.
Whooping Cough
Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.
Whooping Cough
All five cloned human somatostatin receptors (hSSTR1-5) are functionally coupled to adenylyl cyclase.
Whooping Cough
Allosteric Activation of Bordetella pertussis Adenylyl Cyclase by Calmodulin: MOLECULAR DYNAMICS AND MUTAGENESIS STUDIES.
Whooping Cough
Almost half of the RTX domain is dispensable for complement receptor 3 binding and cell-invasive activity of the Bordetella adenylate cyclase toxin.
Whooping Cough
Alpha 1-adrenergic receptor-linked guanine nucleotide-binding protein in muscle and kidney epithelial cells.
Whooping Cough
Alpha 1-adrenoceptor-mediated inhibition of cellular cAMP accumulation in neonatal rat ventricular myocytes.
Whooping Cough
Alpha 2-adrenergic receptors activate phospholipase C in renal epithelial cells.
Whooping Cough
Alpha 2-adrenergic receptors in brown adipose tissue of infant rats--II. Studies on function and regulation.
Whooping Cough
Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.
Whooping Cough
Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels.
Whooping Cough
Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig.
Whooping Cough
Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase.
Whooping Cough
Alpha2-adrenoceptor-mediated enhancement of glycine response in rat sacral dorsal commissural neurons.
Whooping Cough
Alteration of intracellular cAMP levels and beating rates of cultured chick cardiac cells by Bordetella pertussis adenylate cyclase.
Whooping Cough
Alterations in cardiac membrane beta-adrenoceptors and adenylyl cyclase due to hypochlorous acid.
Whooping Cough
Alterations in G-proteins and beta-adrenergic responsive adenylyl cyclase in rat urinary bladder during aging.
Whooping Cough
Alterations in G-proteins in congestive heart failure in cardiomyopathic (UM-X7.1) hamsters.
Whooping Cough
Altered activity of the inhibitory guanyl nucleotide-binding component (Ni) induced by pertussis toxin. Uncoupling of Ni from receptor with continued coupling of Ni to the catalytic unit.
Whooping Cough
Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) in experimental hepatocellular carcinoma.
Whooping Cough
Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.
Whooping Cough
Amino acid-specific ADP-ribosylation. Sensitivity to hydroxylamine of [cysteine(ADP-ribose)]protein and [arginine(ADP-ribose)]protein linkages.
Whooping Cough
Amphiphile-mediated activation of soluble adenylate cyclase of Bordetella pertussis.
Whooping Cough
Amplification of cyclic AMP generation reveals agonistic effects of certain beta-adrenergic antagonists.
Whooping Cough
Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.
Whooping Cough
Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system.
Whooping Cough
An amphipathic alpha-helix including glutamates 509 and 516 is crucial for membrane translocation of adenylate cyclase toxin and modulates formation and cation selectivity of its membrane channels.
Whooping Cough
An Escherichia coli insertion element (IS2) provides a functional promoter in Bordetella pertussis.
Whooping Cough
An evaluation of serious neurological disorders following immunization: a comparison of whole-cell pertussis and acellular pertussis vaccines.
Whooping Cough
An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis.
Whooping Cough
An increase in antimycobacterial Th1-cell responses by prime-boost protocols of immunization does not enhance protection against tuberculosis.
Whooping Cough
An intact N terminus of the gamma subunit is required for the Gbetagamma stimulation of rhodopsin phosphorylation by human beta-adrenergic receptor kinase-1 but not for kinase binding.
Whooping Cough
An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteins.
Whooping Cough
An M2 muscarinic receptor subtype coupled to both adenylyl cyclase and phosphoinositide turnover.
Whooping Cough
Analysis of Bordetella pertussis cya operon regulation by use of cya-lac fusions.
Whooping Cough
Analysis of Membrane Protein Interactions with a Bacterial Adenylate Cyclase-Based Two-Hybrid (BACTH) Technique.
Whooping Cough
Analysis of the chromosomal location of two copies of a Bordetella pertussis insertion sequence.
Whooping Cough
Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase.
Whooping Cough
Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors.
Whooping Cough
Angiopeptin (BIM23014C) inhibits vascular smooth muscle cell migration in vitro through a G-protein-mediated pathway and is associated with inhibition of adenylyl cyclase and cyclic AMP accumulation.
Whooping Cough
Angiotensin II and dopamine modulate both cAMP and inositol phosphate productions in anterior pituitary cells. Involvement in prolactin secretion.
Whooping Cough
Angiotensin II inhibits protein kinase A-dependent chloride conductance in heart via pertussis toxin-sensitive G proteins.
Whooping Cough
Angiotensin II receptor recognized by DuP753 regulates two distinct guanine nucleotide-binding protein signaling pathways.
Whooping Cough
Angiotensin II stimulates the synthesis of angiotensinogen in hepatocytes by inhibiting adenylylcyclase activity and stabilizing angiotensinogen mRNA.
Whooping Cough
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.
Whooping Cough
Anti-viral protection conferred by recombinant adenylate cyclase toxins from Bordetella pertussis carrying a CD8+ T cell epitope from lymphocytic choriomeningitis virus.
Whooping Cough
Antibodies to Bordetella pertussis adenylate cyclase are produced in man during pertussis infection and after vaccination.
Whooping Cough
Antibodies to Bordetella pertussis adenylate cyclase toxin in neonatal and maternal sera.
Whooping Cough
Antibodies to the ras gene product inhibit adenylate cyclase and accelerate progesterone-induced cell division in Xenopus laevis oocytes.
Whooping Cough
Antigen targeting to CD11b allows efficient presentation of CD4+ and CD8+ T cell epitopes and in vivo Th1-polarized T cell priming.
Whooping Cough
Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses.
Whooping Cough
Apical and basolateral effects of PTH in OK cells: transport inhibition, messenger production, effects of pertussis toxin, and interaction with a PTH analog.
Whooping Cough
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B.
Whooping Cough
Assay of pertussis vaccine reactivity factors by measurement of the paw swelling response, endotoxin and histamine-sensitizing factor.
Whooping Cough
Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin.
Whooping Cough
ATP receptor regulation of adenylate cyclase and protein kinase C activity in cultured renal LLC-PK1 cells.
Whooping Cough
ATP stimulates Na+-glucose cotransporter activity via cAMP and p38 MAPK in renal proximal tubule cells.
Whooping Cough
Atrial natriuretic factor reduces cyclic adenosine monophosphate content of human fibroblasts by enhancing phosphodiesterase activity.
Whooping Cough
Atrial natriuretic peptide inhibits iodide uptake and thyroglobulin messenger ribonucleic acid expression in cultured bovine thyroid follicles.
Whooping Cough
Attenuation of chick heart adenylate cyclase by muscarinic receptors after pertussis toxin treatment.
Whooping Cough
Attenuation of parasite cAMP levels in T. cruzi-host cell membrane interactions in vitro.
Whooping Cough
Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.
Whooping Cough
Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner.
Whooping Cough
B cell differentiation factor-induced B cell maturation: regulation via reduction in cAMP.
Whooping Cough
Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells.
Whooping Cough
Beta gamma-mediated enhancement of corticotropin-releasing hormone-stimulated adenylyl cyclase activity by activation of gamma-aminobutyric acid(B) receptors in membranes of rat frontal cortex.
Whooping Cough
Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).
Whooping Cough
Beta-adrenoceptor-linked signal transduction in ischemic-reperfused heart and scavenging of oxyradicals.
Whooping Cough
Beta1-adrenoceptors in rat anterior pituitary may be constitutively active. Inverse agonism of CGP 20712A on basal 3',5'-cyclic adenosine 5'-monophosphate levels.
Whooping Cough
Bimodal regulation of cyclic AMP by muscarinic receptors. Involvement of multiple G proteins and different forms of adenylyl cyclase.
Whooping Cough
Binding of 3'-anthraniloyl-2'-deoxy-ATP to calmodulin-activated adenylate cyclase from Bordetella pertussis and Bacillus anthracis.
Whooping Cough
Binding of regulatory subunits of cyclic AMP-dependent protein kinase to cyclic CMP agarose.
Whooping Cough
Biochemical and physical analyses of newly synthesized muscarinic acetylcholine receptors in cultured embryonic chicken cardiac cells.
Whooping Cough
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Whooping Cough
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy.
Whooping Cough
Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes.
Whooping Cough
Bioinformatics-enabled identification of the HrpL regulon and type III secretion system effector proteins of Pseudomonas syringae pv. phaseolicola 1448A.
Whooping Cough
Biomimetic tethered lipid membranes designed for membrane-protein interaction studies.
Whooping Cough
Biphasic alterations in cardiac beta-adrenoceptor signal transduction mechanism due to oxyradicals.
Whooping Cough
Biphasic effect of sodium fluoride and guanyl nucleotides on binding to prostaglandin E2 receptors in rat epididymal adipocyte membranes.
Whooping Cough
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
Whooping Cough
Block V RTX Domain of Adenylate Cyclase from Bordetella pertussis: A Conformationally Dynamic Scaffold for Protein Engineering Applications.
Whooping Cough
Bordetella adenylate cyclase is a virulence associated factor and an immunoprotective antigen.
Whooping Cough
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
Whooping Cough
Bordetella Adenylate Cyclase Toxin Elicits Airway Mucin Secretion through Activation of the cAMP Response Element Binding Protein.
Whooping Cough
Bordetella adenylate cyclase toxin induces a cascade of morphological changes of sheep erythrocytes and localizes into clusters in erythrocyte membranes.
Whooping Cough
Bordetella Adenylate Cyclase Toxin Inhibits Monocyte-to-Macrophage Transition and Dedifferentiates Human Alveolar Macrophages into Monocyte-like Cells.
Whooping Cough
Bordetella adenylate cyclase toxin interacts with filamentous haemagglutinin to inhibit biofilm formation in vitro.
Whooping Cough
Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3.
Whooping Cough
Bordetella adenylate cyclase toxin promotes calcium entry into both CD11b+ and CD11b- cells through cAMP-dependent L-type-like calcium channels.
Whooping Cough
Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.
Whooping Cough
Bordetella adenylate cyclase toxin: entry of bacterial adenylate cyclase into mammalian cells.
Whooping Cough
Bordetella Dermonecrotic Toxin Is a Neurotropic Virulence Factor That Uses CaV3.1 as the Cell Surface Receptor.
Whooping Cough
Bordetella pertussis adenylate cyclase activity in nasopharyngeal aspirates for rapid diagnosis of whooping cough in relation to culture and serology.
Whooping Cough
Bordetella pertussis adenylate cyclase delivers chemically coupled CD8+ T-cell epitopes to dendritic cells and elicits CTL in vivo.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1).
Whooping Cough
Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin as a tool to analyze molecular interactions in a bacterial two-hybrid system.
Whooping Cough
Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase.
Whooping Cough
Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.
Whooping Cough
Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin. Structural and functional independence of the catalytic and hemolytic activities.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin: a vehicle to deliver CD8-positive T-cell epitopes into antigen-presenting cells.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin: intoxication of host cells by bacterial invasion.
Whooping Cough
Bordetella pertussis adenylate cyclase toxin: proCyaA and CyaC proteins synthesised separately in Escherichia coli produce active toxin in vitro.
Whooping Cough
Bordetella pertussis adenylate cyclase. Identification of multiple forms of the enzyme by antibodies.
Whooping Cough
Bordetella pertussis adenylate cyclase. Purification, characterization, and radioimmunoassay.
Whooping Cough
Bordetella pertussis adenylate cyclase: effects of affinity-purified adenylate cyclase on human polymorphonuclear leukocyte functions.
Whooping Cough
Bordetella pertussis adenylate cyclase: isolation and purification by calmodulin-sepharose 4B chromatography.
Whooping Cough
Bordetella pertussis adenylate cyclase: purification and characterization of the toxic form of the enzyme.
Whooping Cough
Bordetella pertussis commits human dendritic cells to promote a Th1/Th17 response through the activity of adenylate cyclase toxin and MAPK-pathways.
Whooping Cough
Bordetella pertussis infection of human monocytes inhibits antigen-dependent CD4 T cell proliferation.
Whooping Cough
Bordetella pertussis infection: pathogenesis, diagnosis, management, and the role of protective immunity.
Whooping Cough
Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.
Whooping Cough
Bordetella pertussis invasive adenylate cyclase. Partial resolution and properties of its cellular penetration.
Whooping Cough
Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A.
Whooping Cough
Bordetella pertussis virulence factors affect phagocytosis by human neutrophils.
Whooping Cough
Both adenylate cyclase and hemolytic activities are required by Bordetella pertussis to initiate infection.
Whooping Cough
Both pertussis toxin-sensitive and insensitive g-proteins link melatonin receptor to inhibition of adenylate cyclase in the ovine pars tuberalis.
Whooping Cough
Bovine pituitary, kidney, uterine and mammary gland extracts contain bovine mammary epithelium growth factors that synergise with IGF-I and fetal calf serum: indication for involvement of GTP-binding proteins.
Whooping Cough
Bradykinin inhibits adenylate cyclase activity in guinea pig ileum membranes via a separate high-affinity bradykinin B2 receptor.
Whooping Cough
Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.
Whooping Cough
Bromocriptine, a dopamine D2 receptor agonist, inhibits adenylyl cyclase activity in rat olfactory epithelium.
Whooping Cough
Calcium inhibition of cardiac adenylyl cyclase. Evidence for two distinct sites of inhibition.
Whooping Cough
Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form.
Whooping Cough
Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
Whooping Cough
Calcium-Driven Folding of RTX Domain ?-Rolls Ratchets Translocation of RTX Proteins through Type I Secretion Ducts.
Whooping Cough
Calcium-independent stimulation of Bordetella pertussis adenylate cyclase by calmodulin.
Whooping Cough
Calcium-induced folding and stabilization of the intrinsically disordered RTX domain of the CyaA toxin.
Whooping Cough
Calcium-induced folding of a beta roll motif requires C-terminal entropic stabilization.
Whooping Cough
Calcium-induced folding of intrinsically disordered Repeat-in-Toxin (RTX) motifs via changes of protein charges and oligomerization states.
Whooping Cough
Calmodulin binding of a peptide derived from the regulatory domain of Bordetella pertussis adenylate cyclase.
Whooping Cough
Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.
Whooping Cough
Calmodulin inhibits entry of Bordetella pertussis adenylate cyclase into animal cells.
Whooping Cough
Calmodulin-induced conformational and hydrodynamic changes in the catalytic domain of Bordetella pertussis adenylate cyclase toxin.
Whooping Cough
Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain.
Whooping Cough
cAMP and protein kinase A modulate cholinergic rapid eye movement sleep generation.
Whooping Cough
cAMP regulates G-protein alpha i-2 subunit gene transcription in polarized LLC-PK1 cells by induction of a CCAAT box nuclear binding factor.
Whooping Cough
cAMP Signaling of Adenylate Cyclase Toxin Blocks the Oxidative Burst of Neutrophils through Epac-Mediated Inhibition of Phospholipase C Activity.
Whooping Cough
cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.
Whooping Cough
Cannabinoid CB1 receptor-mediated inhibition of prolactin release and signaling mechanisms in GH4C1 cells.
Whooping Cough
Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin 2 (IL-2) expression in the murine T-cell line, EL4.IL-2.
Whooping Cough
Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures.
Whooping Cough
Cannabinoids modulate voltage sensitive potassium A-current in hippocampal neurons via a cAMP-dependent process.
Whooping Cough
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides.
Whooping Cough
Cardiac beta-adrenoceptors, G-proteins and adenylate cyclase regulation during myocardial hypertrophy.
Whooping Cough
Catecholamine-induced heterologous desensitization of rabbit luteal adenylyl cyclase: loss of luteinizing hormone responsiveness is associated with impaired G-protein function.
Whooping Cough
CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.
Whooping Cough
CCK and gastrin inhibit adenylate cyclase activity through a pertussis toxin-sensitive mechanism in the tumoral rat pancreatic acinar cell line AR 4-2J.
Whooping Cough
Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis.
Whooping Cough
Cell-invasive activity of epitope-tagged adenylate cyclase of Bordetella pertussis allows in vitro presentation of a foreign epitope to CD8+ cytotoxic T cells.
Whooping Cough
Changes in expression of a functional Gi protein in cultured rat heart cells.
Whooping Cough
Channel Formation by LktA of Mannheimia (Pasteurella) haemolytica in Lipid Bilayer Membranes and Comparison of Channel Properties with Other RTX-Cytolysins.
Whooping Cough
Channel formation by RTX-toxins of pathogenic bacteria: Basis of their biological activity.
Whooping Cough
Channel formation in model membranes by the adenylate cyclase toxin of Bordetella pertussis: effect of calcium.
Whooping Cough
Characterisation of the fish sst3 receptor, a member of the SRIF1 receptor family: atypical pharmacological features.
Whooping Cough
Characterization and functional expression of a somatostatin receptor coupled to adenylyl cyclase.
Whooping Cough
Characterization of a chimeric human dopamine D3/D2 receptor functionally coupled to adenylyl cyclase in Chinese hamster ovary cells.
Whooping Cough
Characterization of a Membrane-Active Peptide from the Bordetella pertussis CyaA Toxin.
Whooping Cough
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Whooping Cough
Characterization of a synthetic calmodulin-binding peptide derived from Bacillus anthracis adenylate cyclase.
Whooping Cough
Characterization of adenosine A1 receptor in a cell line (28A) derived from rabbit collecting tubule.
Whooping Cough
Characterization of adenosine A1 receptors in human proximal tubule epithelial (HK-2) cells.
Whooping Cough
Characterization of adenylate cyclase toxin from a mutant of Bordetella pertussis defective in the activator gene, cyaC.
Whooping Cough
Characterization of alpha 2A-adrenergic receptors in GT1 neurosecretory cells.
Whooping Cough
Characterization of beta-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for beta1-, beta2- and beta3-adrenoceptors in rat ileum.
Whooping Cough
Characterization of binding of adenylate cyclase toxin to target cells by flow cytometry.
Whooping Cough
Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line.
Whooping Cough
Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
Whooping Cough
Characterization of murine lung inflammation after infection with parental Bordetella pertussis and mutants deficient in adhesins or toxins.
Whooping Cough
Characterization of mutant Bordetella pertussis adenylate cyclase toxins with reduced affinity for calmodulin. Implications for the mechanism of toxin entry into target cells.
Whooping Cough
Characterization of recombinant Bordetella pertussis adenylate cyclase toxins carrying passenger proteins.
Whooping Cough
Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes.
Whooping Cough
Characterization of the adenosine receptor in cultured embryonic chick atrial myocytes: coupling to modulation of contractility and adenylate cyclase activity and identification by direct radioligand binding.
Whooping Cough
Characterization of the bacterial cell associated calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
Whooping Cough
Characterization of the C-terminal domain essential for toxic activity of adenylate cyclase toxin.
Whooping Cough
Characterization of the calmodulin-binding and of the catalytic domains of Bordetella pertussis adenylate cyclase.
Whooping Cough
Characterization of the Intrinsic Phospholipase A1 Activity of Bordetella pertussis Adenylate Cyclase Toxin.
Whooping Cough
Characterization of the prostaglandin E receptor expressed on a cultured mast cell line, BNu-2cl3.
Whooping Cough
Characterization of the regions involved in the calcium-induced folding of the intrinsically disordered RTX motifs from the bordetella pertussis adenylate cyclase toxin.
Whooping Cough
Charge-dependent secretion of an intrinsically disordered protein via the autotransporter pathway.
Whooping Cough
Charge-dependent translocation of Bordetella pertussis adenylate cyclase toxin into eukaryotic cells: implication for the in vivo delivery of CD8(+) T cell epitopes into antigen-presenting cells.
Whooping Cough
Chemical fatty acylation confers hemolytic and toxic activities to adenylate cyclase protoxin of Bordetella pertussis.
Whooping Cough
Chimeric muscarinic cholinergic:beta-adrenergic receptors that are functionally promiscuous among G proteins.
Whooping Cough
Cholinergic inhibition of cAMP accumulation in Sertoli cells cultured from immature hamsters.
Whooping Cough
Chronic ethanol promotes the neuronal differentiation of NG108-15 cells independently of toxin-sensitive G-proteins.
Whooping Cough
Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice.
Whooping Cough
Chronic muscarinic cholinoceptor stimulation increases adenylyl cyclase responsiveness in rat cardiomyocytes by a decrease in the level of inhibitory G-protein alpha-subunits.
Whooping Cough
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma.
Whooping Cough
Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia.
Whooping Cough
Cloned M1 muscarinic receptors mediate both adenylate cyclase inhibition and phosphoinositide turnover.
Whooping Cough
Clonidine inhibits fluid absorption in the rabbit proximal convoluted renal tubule.
Whooping Cough
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.
Whooping Cough
Cloning and expression of mouse-brain calmodulin as an activator of Bordetella pertussis adenylate cyclase in Escherichia coli.
Whooping Cough
Cloning and expression of the calmodulin-sensitive Bacillus anthracis adenylate cyclase in Escherichia coli.
Whooping Cough
Cloning of the adenylate cyclase genetic determinant of Bordetella pertussis and its expression in Escherichia coli and B. pertussis.
Whooping Cough
Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Whooping Cough
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes.
Whooping Cough
Co-expression of a Ca2+-inhibitable adenylyl cyclase and of a Ca2+-sensing receptor in the cortical thick ascending limb cell of the rat kidney. Inhibition of hormone-dependent cAMP accumulation by extracellular Ca2+.
Whooping Cough
Codeine induces human mast cell chemokine and cytokine production: involvement of G-protein activation.
Whooping Cough
Compartmentalized Cyclic AMP Production by the Bordetella pertussis and Bacillus anthracis Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes.
Whooping Cough
Complementation of mutations in Escherichia coli and Bordetella pertussis by B. pertussis DNA cloned in a broad-host-range cosmid vector.
Whooping Cough
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor.
Whooping Cough
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk?
Whooping Cough
Conformational transitions within the calmodulin-binding site of Bordetella pertussis adenylate cyclase studied by time-resolved fluorescence of Trp242 and circular dichroism.
Whooping Cough
Construction and characterization of Bordetella pertussis mutants lacking the vir-regulated P.69 outer membrane protein.
Whooping Cough
Construction of mini-Tn5cyaA' and its utilization for the identification of genes encoding surface-exposed and secreted proteins in Bordetella bronchiseptica.
Whooping Cough
Continuous Assembly of ?-Roll Structures Is Implicated in the Type I-Dependent Secretion of Large Repeat-in-Toxins (RTX) Proteins.
Whooping Cough
Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation.
Whooping Cough
Contributions of the Hydrophobic Helix 2 of the Bordetella pertussis CyaA-hemolysin to Membrane Permeabilization.
Whooping Cough
Control of cyclic adenosine 3',5'-monophosphate production in osteoclasts: calcitonin-induced persistent activation and homologous desensitization of adenylate cyclase.
Whooping Cough
Cooperative phenomena in binding and activation of Bordetella pertussis adenylate cyclase by calmodulin.
Whooping Cough
Coupling of a cloned rat dopamine-D2 receptor to inhibition of adenylyl cyclase and prolactin secretion.
Whooping Cough
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.
Whooping Cough
Coupling of an endogenous 5-HT1B-like receptor to increases in intracellular calcium through a pertussis toxin-sensitive mechanism in CHO-K1 cells.
Whooping Cough
Coupling of hepatic prostaglandin receptors to adenylate cyclase through a pertussis toxin sensitive guanine nucleotide regulatory protein.
Whooping Cough
Coupling of human alpha 2-adrenoceptor subtypes to regulation of cAMP production in transfected S115 cells.
Whooping Cough
Coupling of the thyrotropin-releasing hormone receptor to phospholipase C by a GTP-binding protein distinct from the inhibitory or stimulatory GTP-binding protein.
Whooping Cough
Covalent cross-linking of prostaglandin E receptor from bovine adrenal medulla with a pertussis toxin-insensitive guanine nucleotide-binding protein.
Whooping Cough
Cross-talk between metabotropic glutamate receptor 7 and beta adrenergic receptor signaling at cerebrocortical nerve terminals.
Whooping Cough
Crosstalk between thrombin and adenylyl cyclase-stimulating agonists in proliferating human erythroid progenitor cells.
Whooping Cough
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
Whooping Cough
Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin.
Whooping Cough
Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.
Whooping Cough
Cytoplasmic domain of natriuretic peptide receptor C constitutes Gi activator sequences that inhibit adenylyl cyclase activity.
Whooping Cough
Cytoplasmic domain of natriuretic peptide receptor-C inhibits adenylyl cyclase. Involvement of a pertussis toxin-sensitive G protein.
Whooping Cough
D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe. Abolition by pertussis toxin or activators of adenylate cyclase.
Whooping Cough
D3 dopamine receptor activates phospholipase D through a pertussis toxin-insensitive pathway.
Whooping Cough
Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization.
Whooping Cough
Deletions affecting hemolytic and toxin activities of Bordetella pertussis adenylate cyclase.
Whooping Cough
Delivery of a MalE CD4(+)-T-cell epitope into the major histocompatibility complex class II antigen presentation pathway by Bordetella pertussis adenylate cyclase.
Whooping Cough
Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles.
Whooping Cough
Delivery of CD8(+) T-cell epitopes into major histocompatibility complex class I antigen presentation pathway by Bordetella pertussis adenylate cyclase: delineation of cell invasive structures and permissive insertion sites.
Whooping Cough
Delivery of multiple epitopes by recombinant detoxified adenylate cyclase of Bordetella pertussis induces protective antiviral immunity.
Whooping Cough
Delivery of the HIV-1 Tat protein to dendritic cells by the CyaA vector induces specific Th1 responses and high affinity neutralizing antibodies in non human primates.
Whooping Cough
delta-Opioid receptor activates cAMP phosphodiesterase activities in neuroblastoma x glioma NG108-15 hybrid cells.
Whooping Cough
Demonstration of both A1 and A2 adenosine receptors in DDT1 MF-2 smooth muscle cells.
Whooping Cough
Dermonecrotic toxin and tracheal cytotoxin, putative virulence factors of Bordetella avium.
Whooping Cough
Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases.
Whooping Cough
Detection of antibodies against fimbria type 3 (Fim3) is useful diagnostic assay for pertussis.
Whooping Cough
Detection of Bordetella pertussis by determination of adenylate cyclase activity.
Whooping Cough
Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells.
Whooping Cough
Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice.
Whooping Cough
Determination of serum antibody to Bordetella pertussis adenylate cyclase toxin in vaccinated and unvaccinated children and in children and adults with pertussis.
Whooping Cough
Development and validation of a robust multiplex serological assay to quantify antibodies specific to pertussis antigens.
Whooping Cough
Development of a Premature Stop Codon-detection method based on a bacterial two-hybrid system.
Whooping Cough
Development of a targeted nanoLC-MS/MS method for quantitation of residual toxins from Bordetella pertussis.
Whooping Cough
Development of an approach for the laboratory toxicological evaluation of Bordetella pertussis adenylate cyclase genetic toxoid constructs as multipurpose vaccines.
Whooping Cough
Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat.
Whooping Cough
Dexamethasone effects on beta-adrenergic receptors and adenylate cyclase regulatory proteins Gs and Gi in ROS 17/2.8 cells.
Whooping Cough
Differences in Purinergic Amplification of Osmotic Cell Lysis by the Pore-Forming RTX Toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: The Role of Pore Size.
Whooping Cough
Different modes of membrane permeabilization by two RTX toxins: HlyA from Escherichia coli and CyaA from Bordetella pertussis.
Whooping Cough
Different sites of action of arachidonic acid on steroidogenesis in rat Leydig cells.
Whooping Cough
Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells.
Whooping Cough
Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction.
Whooping Cough
Differential coupling of m1, m2 and m3 muscarinic receptor subtypes to inositol 1,4,5-trisphosphate and adenosine 3',5'-cyclic monophosphate accumulation in Chinese hamster ovary cells.
Whooping Cough
Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes.
Whooping Cough
Differential coupling of the extreme C-terminus of G protein alpha subunits to the G protein-coupled melatonin receptors.
Whooping Cough
Differential coupling of the formyl peptide receptor to adenylate cyclase and phospholipase C by the pertussis toxin-insensitive Gz protein.
Whooping Cough
Differential coupling with pertussis toxin-sensitive G proteins of dopamine and somatostatin receptors involved in regulation of adenohypophyseal secretion.
Whooping Cough
Differential effects of fluoride and a non-hydrolysable GTP analogue on adenylate cyclase and G-proteins in Ceratitis capitata neural tissue.
Whooping Cough
Differential inhibition of adenylyl cyclase isoforms and soluble guanylyl cyclase by purine and pyrimidine nucleotides.
Whooping Cough
Differential mechanisms for calcium-dependent protein/membrane association as evidenced from SPR-binding studies on supported biomimetic membranes.
Whooping Cough
Differential regulation of actin-activated nucleotidyl cyclase virulence factors by filamentous and globular actin.
Whooping Cough
Differential regulation of cAMP-mediated gene transcription by m1 and m4 muscarinic acetylcholine receptors. Preferential coupling of m4 receptors to Gi alpha-2.
Whooping Cough
Differential role of calmodulin and calcium ions in the stabilization of the catalytic domain of adenyl cyclase CyaA from Bordetella pertussis.
Whooping Cough
Differential sensitivity of alpha o and alpha i to ADP-ribosylation by pertussis toxin in the intact cultured embryonic chick ventricular myocyte. Relationship to the role of G proteins in the coupling of muscarinic cholinergic receptors to inhibition of adenylate cyclase activity.
Whooping Cough
Differentiation of Neuro-2a neuroblastoma cells by an antibody to GM3 ganglioside.
Whooping Cough
Differentiation of renal Na(+)-K(+)-ATPase in control and streptozotocin-induced diabetic mice by G-protein acting toxins and phorbol esters.
Whooping Cough
Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells.
Whooping Cough
Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells.
Whooping Cough
Direct delivery of the Bordetella pertussis adenylate cyclase toxin to the MHC class I antigen presentation pathway.
Whooping Cough
Direct effect of adenosine on prolactin secretion at the level of the single rat lactotroph: involvement of pertussis toxin-sensitive and -insensitive transducing mechanisms.
Whooping Cough
Direct inhibitory effects of a somatostatin analog, SMS 201-995, on AR4-2J cell proliferation via pertussis toxin-sensitive guanosine triphosphate-binding protein-independent mechanism.
Whooping Cough
Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.
Whooping Cough
Direct stimulation of adenylate cyclase by mechanical forces in S49 mouse lymphoma cells during hyposmotic swelling.
Whooping Cough
Disorder-to-order transition in the CyaA toxin RTX domain: implications for toxin secretion.
Whooping Cough
Disparate effects of neuropeptide Y and clonidine on the excretion of sodium and water in the rat.
Whooping Cough
Dissociation between muscarinic receptor-mediated inhibition of adenylate cyclase and autoreceptor inhibition of [3H] acetylcholine release in rat hippocampus.
Whooping Cough
Dissociation of catalytic and invasive activities of Bordetella pertussis adenylate cyclase.
Whooping Cough
Distinct mechanisms for K+ efflux, intoxication, and hemolysis by Bordetella pertussis AC toxin.
Whooping Cough
Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling.
Whooping Cough
Distinct steps in the penetration of adenylate cyclase toxin of Bordetella pertussis into sheep erythrocytes. Translocation of the toxin across the membrane.
Whooping Cough
Distinctive and synergistic signaling of human adenosine A2a and dopamine D2L receptors in CHO cells.
Whooping Cough
Divalent cations suppress 3',5'-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells.
Whooping Cough
Does the guanine nucleotide regulatory protein Ni mediate progesterone inhibition of Xenopus oocyte adenylate cyclase?
Whooping Cough
Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification.
Whooping Cough
Dopamine D2L receptor couples to G alpha i2 and G alpha i3 but not G alpha i1, leading to the inhibition of adenylate cyclase in transfected cell lines.
Whooping Cough
Dopamine stimulates 45Ca2+ uptake through cAMP, PLC/PKC, and MAPKs in renal proximal tubule cells.
Whooping Cough
Dopaminergic receptors linked to adenylate cyclase in human cerebromicrovascular endothelium.
Whooping Cough
Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling.
Whooping Cough
Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s).
Whooping Cough
Dual effects of calcitonin and calcitonin gene-related peptide on intracellular cyclic 3',5'-monophosphate in a human breast cancer cell line.
Whooping Cough
Dual effects of DAMGO [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin and CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2) on adenylyl cyclase activity: implications for mu-opioid receptor Gs coupling.
Whooping Cough
Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor.
Whooping Cough
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Whooping Cough
Dual regulation of cyclic AMP formation by thrombin in HEL cells, a leukaemic cell line with megakaryocytic properties.
Whooping Cough
Dual regulation of neutrophil adenylate cyclase by fluoride and its relationship to cellular activation.
Whooping Cough
Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.
Whooping Cough
Dysfunction of the beta- and alpha-adrenergic systems in a model of congestive heart failure. The pacing-overdrive dog.
Whooping Cough
Effect of bacterial toxins on spermine-induced inhibition of adenylate cyclase activity of cultured heart cells.
Whooping Cough
Effect of Bordetella pertussis toxin on ADP-ribosylation of membrane proteins, adenylate cyclase activity and insulin release in rat pancreatic islets.
Whooping Cough
Effect of calcitonin gene-related peptide on skeletal muscle via specific binding site and G protein.
Whooping Cough
Effect of cholera toxin and pertussis toxin on opioid tolerance and dependence in the guinea-pig myenteric plexus.
Whooping Cough
Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes.
Whooping Cough
Effect of different forms of adenylate cyclase toxin of Bordetella pertussis on protection afforded by an acellular pertussis vaccine in a murine model.
Whooping Cough
Effect of different levels of intracellular cAMP on the in vitro maturation of cattle oocytes and their subsequent development following in vitro fertilization.
Whooping Cough
Effect of GHRH and peptides from the vasoactive intestinal peptide family on cAMP production of human cancer cell lines in vitro.
Whooping Cough
Effect of glucocorticoid on prostaglandin E1 mediated cyclic AMP formation by vascular smooth muscle cells.
Whooping Cough
Effect of islet-activating pertussis toxin on the binding characteristics of Ca2+-mobilizing hormones and on agonist activation of phosphorylase in hepatocytes.
Whooping Cough
Effect of methyl-cyclodextrin on adenylate cyclase activity of Bordetella pertussis.
Whooping Cough
Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.
Whooping Cough
Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists.
Whooping Cough
Effect of pertussis toxin on the hormonal regulation of cyclic AMP levels in hamster fat cells.
Whooping Cough
Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells.
Whooping Cough
Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat.
Whooping Cough
Effect of PT-treatment on ANP-mediated inhibition of adenylate cyclase and amylase release in rat parotid gland.
Whooping Cough
Effect of somatostatin on adenylate cyclase activity in normal and neoplastic thyroid tissue.
Whooping Cough
Effect of sulpiride on somatostatin receptors, somatostatin-like immunoreactivity and modulation of adenylyl cyclase activity in the rat brain.
Whooping Cough
Effect of temperature and host factors on the activities of pertussis toxin and Bordetella adenylate cyclase.
Whooping Cough
Effector coupling of somatostatin receptor subtypes on human endocrine tumors.
Whooping Cough
Effector coupling of stably transfected human A3 adenosine receptors in CHO cells.
Whooping Cough
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Whooping Cough
Effects of adenylate cyclase toxin from Bordetella pertussis on human neutrophil interactions with Coccidioides immitis and Staphylococcus aureus.
Whooping Cough
Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets.
Whooping Cough
Effects of calcium-antagonists on dopamine release in the central nervous system--possible interactions with D2-autoreceptors and guanosine triphosphate-binding proteins.
Whooping Cough
Effects of drugs acting on adrenergic and adenosine receptors on the intraocular pressure and the activity of adenylyl cyclase in ciliary processes and their sensitivity to pertussis toxin.
Whooping Cough
Effects of exercise on myocardial adenylate cyclase and Gi alpha expression in senescence.
Whooping Cough
Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin.
Whooping Cough
Effects of insulin, adenosine, and prostaglandin on alpha-adrenergic-stimulated respiration in brown adipocytes.
Whooping Cough
Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy.
Whooping Cough
Effects of pertussis toxin on adenylate cyclase responses to prostaglandin E2 and calcitonin in human breast cancer cells.
Whooping Cough
Effects of pertussis toxin on cAMP and cGMP responses to carbamylcholine in N1E-115 neuroblastoma cells.
Whooping Cough
Effects of pertussis toxin on intraocular pressure and adenylate cyclase activity of ciliary processes in rabbits.
Whooping Cough
Effects of pertussis toxin on vasodilation and cyclic GMP in bovine mesenteric arteries and demonstration of a 40 kD soluble protein ribosylation substrate for pertussis toxin.
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Effects of pertussis toxin treatment of rats on estradiol-induced adenohypophyseal growth reaction and on adrenergic lipolysis.
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Effects of pertussis toxin treatment on metabolism in hamster brown adipocytes.
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Effects of pertussis toxin-catalyzed ADP-ribosylation on interactions of transducin and the inhibitory GTP-binding protein of adenylate cyclase with guanyl nucleotides.
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Efficient Ex vivo stimulation of Mycobacterium tuberculosis-specific T cells by genetically detoxified Bordetella pertussis adenylate cyclase antigen toxoids.
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Electrophysiologic responses and adenylate cyclase activities of mouse spinal cord-dorsal root ganglion explants rendered tolerant by chronic exposure to morphine or pertussis toxin.
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Endogenous ADP-ribosylation of Gs subunit and autonomous regulation of adenylate cyclase.
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Endothelin inhibits adenylate cyclase and stimulates phosphoinositide hydrolysis in adult cardiac myocytes.
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Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization.
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Endothelin(B) receptor activates NHE-3 by a Ca2+-dependent pathway in OKP cells.
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Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.
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Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition.
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Enhancement of differentiation of cultured adipogenic cells (TA1) by pertussis toxin.
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Enhancement of parathyroid hormone-responsive renal cortical adenylate cyclase activity by a cytosol protein activator from rat reticulocytes.
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Enzymatic activity of adenylate cyclase toxin from Bordetella pertussis is not required for hemolysis.
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Enzymatic synthesis of the cAMP antagonist (Rp)-adenosine 3',5'-monophosphorothioate on a preparative scale.
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Epidermal growth factor activation of rat parotid gland adenylate cyclase and mediation by a GTP-binding regulatory protein.
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Epidermal growth factor-induced heterologous desensitization of the luteinizing hormone/choriogonadotropin receptor in a cell-free membrane preparation is associated with the tyrosine phosphorylation of the epidermal growth factor receptor.
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Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin.
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Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein.
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Eradication of large tumors in mice by a tritherapy targeting the innate, adaptive, and regulatory components of the immune system.
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Essential role of methionine residues in calmodulin binding to Bordetella pertussis adenylate cyclase, as probed by selective oxidation and repair by the peptide methionine sulfoxide reductases.
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Estradiol increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
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Evaluation of adenyl cyclase toxin constructs from Bordetella pertussis as candidate vaccine components in an in vitro model of complement-dependent intraphagocytic killing.
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Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice.
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Evaluation of the toxicity of recombinant Bordetella pertussis adenylate cyclase toxin preparations.
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Evidence for the presence of serotonin receptors negatively coupled to adenylate cyclase in the rabbit iris-ciliary body.
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Evidence for the role of heterotrimeric guanine nucleotide-binding regulatory proteins in the regulation of the mouse sperm adenylyl cyclase by the egg's zona pellucida.
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Evidence for two GTPases activated by thrombin in membranes of human platelets.
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Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas.
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Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons.
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Evidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems.
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Evidence that muscarinic receptors in islet cells are not coupled functionally to adenylate cyclase through the inhibitory guanine nucleotide binding protein (Ni).
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Evidence that the adenylate cyclase secreted from Bordetella pertussis does not enter animal cells by receptor-mediated endocytosis.
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Evidence that the epidermal growth factor receptor and non-tyrosine kinase hormone receptors stimulate phosphoinositide hydrolysis by independent pathways.
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ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation.
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Exposure to Bordetella pertussis adenylate cyclase toxin affects integrin-mediated adhesion and mechanics in alveolar epithelial cells.
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Expression and pharmacological characterization of a stimulatory subtype of adenosine receptor in fetal chick ventricular myocytes.
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Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.
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Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs.
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Expression of functionally active cannabinoid receptor CB1 in the human prostate gland.
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Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.
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Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase.
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Extracellular cAMP formation from host cell ATP by Bordetella pertussis adenylate cyclase.
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Facilitative actions of the protein kinase-C effector system on hormonally stimulated adenosine 3',5'-monophosphate production by swine luteal cells.
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Facilitatory effects of diltiazem on dopamine release in the central nervous system. Focus on interactions with D2 autoreceptors and guanosine triphosphate binding proteins.
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Fatal Bordetella pertussis infection: report of two cases with novel pathologic findings.
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Fibroblast growth factor potentiates receptor- and nonreceptor-mediated stimulation of adenylate cyclase in hamster fibroblasts.
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Fine Epitope Mapping of Two Antibodies Neutralizing the Bordetella Adenylate Cyclase Toxin.
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Fingolimod inhibits glutamate release through activation of S1P1 receptors and the G protein ?? subunit-dependent pathway in rat cerebrocortical nerve terminals.
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Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells.
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Follicle-stimulating hormone receptor-mediated uptake of 45Ca2+ by cultured rat Sertoli cells does not require activation of cholera toxin- or pertussis toxin-sensitive guanine nucleotide binding proteins or adenylate cyclase.
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Formulation of the adenylate cyclase toxin of Bordetella pertussis as protein-coated microcrystals.
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Functional analysis of a human A(1) adenosine receptor/green fluorescent protein/G(i1)alpha fusion protein following stable expression in CHO cells.
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Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin.
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Functional and structural studies on different forms of the adenylate cyclase toxin of Bordetella pertussis.
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Functional characterisation of the Drosophila 5-HTdro1 and 5-HTdro2B serotonin receptors in insect cells: activation of a G(alpha) s-like protein by 5-HTdro1 but lack of coupling to inhibitory G-proteins by 5-HTdro2B.
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Functional characterization of the human dopamine D4.2 receptor using vaccinia virus as an expression system.
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Functional consequences of single amino acid substitutions in calmodulin-activated adenylate cyclase of Bordetella pertussis.
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Functional coupling of cerebral ?-aminobutyric acid (GABA)(B) receptor with adenylate cyclase system: effect of phaclofen.
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Functional coupling of the alpha 2-adrenergic receptor-adenylate cyclase complex in the pregnant human myometrium.
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Functional interaction of prostaglandin E receptor EP3 subtype with guanine nucleotide-binding proteins, showing low-affinity ligand binding.
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Functional maturation of somatostatin neurons and somatostatin receptors during development of mouse hypothalamus in vivo and in vitro.
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Functional role of amino-terminal serine16 and serine27 of G alphaZ in receptor and effector coupling.
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Functional uncoupling of muscarinic receptors from adenylate cyclase in rat cardiac membranes by the active component of islet-activating protein, pertussis toxin.
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G protein activation and cyclic AMP modulation by naloxone benzoylhydrazone in distinct layers of rat olfactory bulb.
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G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
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G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.
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G proteins in Aplysia: biochemical characterization and regional and subcellular distribution.
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G regulatory proteins and muscarinic receptor signal transduction in mucous acini of rat submandibular gland.
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G(z) can mediate the acute actions of mu- and kappa-opioids but is not involved in opioid-induced adenylyl cyclase supersensitization.
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G-protein level quantification in platelets and leukocytes from patients with panic disorder.
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G-proteins and adenylyl cyclase in ovarian granulosa cells of amago salmon (Oncorhynchus rhodurus).
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G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate.
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G?s proteins activate p72(Syk) and p60-c-Src tyrosine kinases to mediate sickle red blood cell adhesion to endothelium via LW-?v?3 and CD44-CD44 interactions.
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GABAB and adenosine receptors mediate enhancement of the K+ current, IAHP, by reducing adenylyl cyclase activity in rat CA3 hippocampal neurons.
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Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
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Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein.
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Generation and use of site-directed chromosomal cyaA' translational fusions in Salmonella enterica.
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Genetic analysis of a region of the Bordetella pertussis chromosome encoding filamentous hemagglutinin and the pleiotropic regulatory locus vir.
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Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling.
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Gentamicin nucleotidyltransferase. Stereochemical inversion at phosphorus in enzymatic 2'-deoxyadenylyl transfer to tobramycin.
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Gi alpha 1 selectively couples somatostatin receptors to adenylyl cyclase in pituitary-derived AtT-20 cells.
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Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.
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Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain.
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Growth factor-like action of lysophosphatidic acid: mitogenic signalling mediated by G proteins.
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Growth regulation of primary human keratinocytes by prostaglandin E receptor EP2 and EP3 subtypes.
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GTL001 and bivalent CyaA-based therapeutic vaccine strategies against human papillomavirus and other tumor-associated antigens induce effector and memory T-cell responses that inhibit tumor growth.
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GTL001, a bivalent therapeutic vaccine against human papillomavirus 16 and 18, induces antigen-specific CD8+ T cell responses leading to tumor regression.
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GTP-binding proteins associated with serotonin-activated adenylate cyclase in Fasciola hepatica.
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GTP-binding proteins associated with the human placental syncytiotrophoblast plasma membrane.
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Guanine nucleotide activation and inhibition of adenylate cyclase as modified by islet-activating protein, pertussis toxin, in mouse 3T3 fibroblasts.
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Guanine nucleotide binding proteins in the dual regulation of lacrimal function.
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Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.
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Guanine nucleotide-sensitive, high affinity binding of carbachol to muscarinic cholinergic receptors of 1321N1 astrocytoma cells is insensitive to pertussis toxin.
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Guanosine 5'-O-(3-thiotriphosphate) and guanosine 5'-O-(2-thiodiphosphate) activate G proteins and potentiate fibroblast growth factor-induced DNA synthesis in hamster fibroblasts.
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Guanosine 5'-O-(3-thiotriphosphate) reduces ADP-ribosylation of the inhibitory guanine nucleotide-binding regulatory protein of adenylyl cyclase (Ni) by pertussis toxin without causing dissociation of the subunits of Ni. Evidence of existence of heterotrimeric pt+ and pt- conformations of Ni.
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Haemolytic assay for the detection of adenylate cyclase toxin of Bordetella pertussis.
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Halothane interaction with guanine nucleotide binding proteins in mouse heart.
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Halothane myocardial depression: interactions with the adenylate cyclase system.
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Heart contains two substrates (Mr = 40,000 and 41,000) for pertussis toxin-catalyzed ADP-ribosylation that co-purify with Ns.
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Hemolytic, but not cell-invasive activity, of adenylate cyclase toxin is selectively affected by differential fatty-acylation in Escherichia coli.
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Heterotrimeric G proteins containing G alpha i3 regulate multiple effector enzymes in the same cell. Activation of phospholipases C and A2 and inhibition of adenylyl cyclase.
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High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells.
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High frequency of CD4+ T cells specific for the TB10.4 protein correlates with protection against Mycobacterium tuberculosis infection.
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High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2.
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HIGH GLUCOSE-INDUCED INHIBITION OF 2-DEOXYGLUCOSE UPTAKE IS MEDIATED BY cAMP, PROTEIN KINASE C, OXIDATIVE STRESS AND MITOGEN-ACTIVATED PROTEIN KINASES IN MOUSE EMBRYONIC STEM CELLS.
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High level expression of transfected G protein alpha i3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts.
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High level of soluble expression in Escherichia coli and characterisation of the CyaA pore-forming fragment from a Bordetella pertussis Thai clinical isolate.
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High-affinity calmodulin binding is required for the rapid entry of Bordetella pertussis adenylyl cyclase into neuroblastoma cells.
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High-level synthesis of active adenylate cyclase toxin of Bordetella pertussis in a reconstructed Escherichia coli system.
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Histidine regulation of cyclic AMP metabolism in cultured renal epithelial LLC-PK1 cells.
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Homologous and heterologous beta-adrenergic desensitization in hepatocytes. Additivity and effect of pertussis toxin.
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Homologous sensitisation of embryonic chick atrial myocytes to adenosine: mediation by adenosine A1 receptor and guanine nucleotide binding protein.
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Human chorionic gonadotropin-induced heterologous desensitization of rabbit luteal adenylyl cyclase is associated with altered receptor and G-protein function.
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Human serologic response to envelope-associated proteins and adenylate cyclase toxin of Bordetella pertussis.
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Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.
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Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels.
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Identification and characterization of guanine nucleotide-sensitive melatonin receptors in chicken brain.
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Identification and Characterization of Putative Translocated Effector Proteins of the Edwardsiella ictaluri Type III Secretion System.
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Identification and regulation of cold-inducible factors of Bordetella bronchiseptica.
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Identification and type III-dependent secretion of the Yersinia pestis insecticidal-like proteins.
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Identification by in vitro complementation of regions required for cell-invasive activity of Bordetella pertussis adenylate cyclase toxin.
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Identification of a common domain in calmodulin-activated eukaryotic and bacterial adenylate cyclases.
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Identification of a domain in Bordetella pertussis adenylyl cyclase important for subunit interactions and cell invasion activity.
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Identification of a region that assists membrane insertion and translocation of the catalytic domain of Bordetella pertussis CyaA toxin.
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Identification of Bordetella pertussis in nasopharyngeal swabs by PCR amplification of a region of the adenylate cyclase gene.
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Identification of motifs in cholera toxin A1 polypeptide that are required for its interaction with human ADP-ribosylation factor 6 in a bacterial two-hybrid system.
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Identification of new secreted effectors in Salmonella enterica serovar Typhimurium.
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Identification of novel type III secretion effectors in Xanthomonas oryzae pv. oryzae.
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Identification of residues essential for catalysis and binding of calmodulin in Bordetella pertussis adenylate cyclase by site-directed mutagenesis.
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Identification of the predominant substrate for ADP-ribosylation by islet activating protein.
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Identification, characterization, and biological activity of somatostatin receptors in human neuroblastoma cell lines.
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Identity of adenylyl cyclase isoform determines the G protein mediating chronic opioid-induced adenylyl cyclase supersensitivity.
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Immunization with a circumsporozoite epitope fused to Bordetella pertussis adenylate cyclase in conjunction with cytotoxic T-Lymphocyte-associated antigen 4 blockade confers protection against Plasmodium berghei liver-stage malaria.
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Immunodetectable levels of the inhibitory guanine nucleotide-binding regulatory proteins in failing human heart: discordance with measurements of adenylate cyclase activity and levels of pertussis toxin substrate.
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Immunoelectron microscopy of antigens of Bordetella pertussis using monoclonal antibodies to agglutinogens 2 and 3, filamentous haemagglutinin, pertussis toxin, pertactin and adenylate cyclase toxin.
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Immunological relatedness between Bordetella pertussis and rat brain adenylyl cyclases.
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Impaired substance P release from renal sensory nerves in SHR involves a pertussis toxin-sensitive mechanism.
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Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats.
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Improving administration regimens of CyaA-based vaccines using TRAP assays to detect antigen-specific CD8(+) T cells directly ex vivo.
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In vitro effect of chlorpyrifos oxon on muscarinic receptors and adenylate cyclase.
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In vitro effects of 17 beta-oestradiol on the sensitivity of receptors coupled to adenylate cyclase on striatal neurons in primary culture.
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In vitro selection for enzymatic activity: a model study using adenylate cyclase.
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In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus.
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In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying multiple copies of a viral CD8(+) T-cell epitope.
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In vivo induction of CTL responses by recombinant adenylate cyclase of Bordetella pertussis carrying viral CD8+ T cell epitopes.
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In vivo receptor-mediated delivery of a recombinant invasive bacterial toxoid to CD11c + CD8 alpha -CD11bhigh dendritic cells.
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Independence of, and interactions between, cannabinoid and opioid signal transduction pathways in N18TG2 cells.
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Induction of a polarized Th1 response by insertion of multiple copies of a viral T-cell epitope into adenylate cyclase of Bordetella pertussis.
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Induction of neutralizing antibodies and Th1-polarized and CD4-independent CD8+ T-cell responses following delivery of human immunodeficiency virus type 1 Tat protein by recombinant adenylate cyclase of Bordetella pertussis.
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Infection of L6E9 myoblasts with Trypanosoma cruzi alters adenylate cyclase activity and guanine nucleotide binding proteins.
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Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
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Influence of anti-beta-receptor antibodies on cardiac adenylate cyclase in patients with idiopathic dilated cardiomyopathy.
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Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils.
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Influence of dietary omega-3 fatty acids on transmembrane signalling in rat submandibular salivary gland.
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Influence of pertussis toxin on the effects of guanine nucleotide on adenylate cyclase in rat striatal membranes.
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Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity.
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Influences of pertussis toxin, guanine nucleotides and forskolin on adenylate cyclase in striatal membranes of infant, adult and senescent rats.
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Inhibition by glucagon of the cGMP-inhibited low-Km cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein.
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Inhibition of adenylate cyclase activity in the goldfish melanophore is mediated by alpha2-adrenoceptors and a pertussis toxin-sensitive GTP-binding protein.
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Inhibition of adenylate cyclase from luteinized rat ovary by monovalent cations: roles of the stimulatory guanine nucleotide-binding regulatory component and stimulatory hormone receptor.
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Inhibition of adenylate cyclase in bovine ciliary process and rabbit iris ciliary body to alpha 2-adrenergic agonists.
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Inhibition of adenylyl cyclase activity by a homogeneous population of dopamine receptors: selective blockade by antisera directed against Gi1 and/or Gi2.
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Inhibition of cyclic AMP accumulation by endothelin is pertussis toxin sensitive and calcium independent in isolated adult feline cardiac myocytes.
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Inhibition of fetal rat pancreatic beta-cell replication by interleukin-1 beta in vitro is not mediated through pertussis toxin-sensitive G-proteins, a decrease in cyclic AMP, or protease activation.
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Inhibition of formation of cyclic AMP and cyclic GMP by vasopressin in smooth-muscle cells is insensitive to pertussis toxin.
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Inhibition of FSH-stimulated cAMP accumulation by mono(2-ethylhexyl) phthalate in primary rat Sertoli cell cultures.
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Inhibition of immunological and nonimmunological histamine release from human basophils by adenosine analogues that act at P-sites.
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Inhibition of monocyte oxidative responses by Bordetella pertussis adenylate cyclase toxin.
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Inhibition of noradrenaline release by neuropeptide Y in mouse atria does not involve inhibition of adenylate cyclase or a pertussis toxin-susceptible G protein.
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Inhibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor alpha and epidermal growth factor.
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Inhibition of protein kinase A and cyclic AMP response element (CRE)-specific transcription factor binding by delta9-tetrahydrocannabinol (delta9-THC): a putative mechanism of cannabinoid-induced immune modulation.
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Inhibition of protein phosphatase 2A (PP2A) mimics suckling-induced sensitization of mammotropes: involvement of a pertussis toxin (PTX) sensitive G-protein and the adenylate cyclase (AC).
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Inhibition of renal Na+-ATPase activity by inosine is mediated by A1 receptor-induced inhibition of the cAMP signaling pathway.
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Inhibition of the adenylyl cyclase toxin, edema factor, from Bacillus anthracis by a series of 18 mono- and bis-(M)ANT-substituted nucleoside 5'-triphosphates.
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Inhibition of the cAMP signaling cascade via cannabinoid receptors: a putative mechanism of immune modulation by cannabinoid compounds.
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Inhibitors of receptor-mediated endocytosis block the entry of Bacillus anthracis adenylate cyclase toxin but not that of Bordetella pertussis adenylate cyclase toxin.
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Inhibitory action of forskolin on adenylate cyclase activity and cyclic AMP generation.
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Inhibitory and stimulatory effects of neuropeptide Y(17-36) on rat cardiac adenylate cyclase activity. Structure-function studies.
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Inhibitory effects of pertussis toxin on a depolarization-evoked Ca2+ influx in NG108-15 cells.
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Inhibitory glutamate response on cyclic AMP formation in cultured astrocytes.
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Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes.
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Inhibitory pathway of cardiac PKA-dependent Cl- conductance via pertussis toxin-sensitive G proteins.
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Inositol trisphosphate/Ca2+ as messengers of bradykinin B2 and muscarinic acetylcholine m1-m4 receptors in neuroblastoma-derived hybrid cells.
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Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy.
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Insulin activation of cyclic AMP phosphodiesterase in intact ureteral segments.
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Interaction between prostacyclin and cortisol in fetal lung cells: effects on cAMP production.
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Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells.
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Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding.
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Interaction of Bordetella pertussis adenylate cyclase with calmodulin. Identification of two separated calmodulin-binding domains.
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Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain.
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Interaction of Bordetella pertussis virulence components with neutrophils: effect on chemiluminescence induced by a chemotactic peptide and by intact bacteria.
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Interaction of calcium with Bordetella pertussis adenylate cyclase toxin. Characterization of multiple calcium-binding sites and calcium-induced conformational changes.
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Interaction of somatostatin receptors with G proteins and cellular effector systems.
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Interactions between inhibitory and excitatory modulatory signals in single submucosal neurons.
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Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.
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Interactions of Bordetella pertussis adenylyl cyclase toxin CyaA with calmodulin mutants and calmodulin antagonists: Comparison with membranous adenylyl cyclase I.
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Interleukin-1beta-induced inhibition of hair growth in vitro is mediated by cyclic AMP.
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Internal lysine palmitoylation in adenylate cyclase toxin from Bordetella pertussis.
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Internalization of cloned pancreatic polypeptide receptors is accelerated by all types of Y4 agonists.
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International Union of Pharmacology LVII: Recommendations for the Nomenclature of Receptors for Relaxin Family Peptides.
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Intracellular cross-talk between thyrotropin receptor and A1 adenosine receptor in regulation of phospholipase C and adenylate cyclase in COS-7 cells transfected with their receptor genes.
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Intrinsic fluorescence of a truncated Bordetella pertussis adenylate cyclase expressed in Escherichia coli.
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Invasion of Dendritic Cells, Macrophages and Neutrophils by the Bordetella Adenylate Cyclase Toxin: A Subversive Move to Fool Host Immunity.
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Invasive adenylyl cyclase of Bordetella pertussis. Physical, catalytic, and toxic properties.
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Inventory and functional analysis of the large Hrp regulon in Ralstonia solanacearum: identification of novel effector proteins translocated to plant host cells through the type III secretion system.
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Involvement of both inhibitory and stimulatory guanine nucleotide binding proteins in the expression of chronic opiate regulation of adenylate cyclase activity in NG108-15 cells.
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Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
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Involvement of Ni protein in the functional coupling of the atrial natriuretic factor (ANF) receptor to adenylate cyclase in rat lung plasma membranes.
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Involvement of protein kinase-C in the effect of angiotensin-II on adenosine 3',5'-monophosphate production in lactotroph cells.
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Ionotropic histamine receptors and H2 receptors modulate supraoptic oxytocin neuronal excitability and dye coupling.
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Islet-activating protein impairs alpha 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase.
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Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTP gamma S-induced adenylate cyclase inhibition in rat adipocytes.
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Islet-activating protein, pertussis toxin: a specific uncoupler of receptor-mediated inhibition of adenylate cyclase.
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Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.
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Isobutylmethylxanthine stimulates adenylate cyclase by blocking the inhibitory regulatory protein, Gi.
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Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase.
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Isolation and characterization of natural human IgG with a morphine-like activity.
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Isolation of a protein fraction from Bordetella pertussis that facilitates entry of the calmodulin-sensitive adenylate cyclase into animal cells.
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Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.
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K+ channel and adenylate cyclase involvement in regulation of Ca2+-evoked release of [3H]dopamine from synaptosomes.
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Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling.
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kappa-Opioid receptor-transfected cell lines: modulation of adenylyl cyclase activity following acute and chronic opioid treatments.
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Khellin, but not 8-methoxypsoralen, inhibits adenylyl cyclase system in HeLa cells.
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Linkage between somatostatin and acid secretion: evidence from use of pertussis toxin.
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Long-term neuroleptic treatments counteract dopamine D2 agonist inhibition of adenylate cyclase but do not affect pertussis toxin ADP-ribosylation in the rat brain.
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Loss of activation of Gs but not Gi following expression of an alpha2A-adrenoceptor-Gi1alpha fusion protein.
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Loss of the inhibitory function of the guanine nucleotide regulatory component of adenylate cyclase due to its ADP ribosylation by islet-activating protein, pertussis toxin, in adipocyte membranes.
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Luteinizing hormone secretion is enhanced by pertussis toxin, cholera toxin, and forskolin. Evidence for the involvement of the cyclic AMP-generating system.
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LY320135, a novel cannabinoid CB1 receptor antagonist, unmasks coupling of the CB1 receptor to stimulation of cAMP accumulation.
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Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.
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Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells.
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Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!
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Maintenance of meiotic arrest in isolated rat oocytes by the invasive adenylate cyclase of Bordetella pertussis.
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Mapping structural determinants within 3rd intracellular loop that direct signalling specificity of type 1 corticotropin releasing hormone receptor.
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Mass spectrometric analysis of recombinant adenylate cyclase toxin from Bordetella pertussis strain 18323/pHSP9.
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Mechanism for increase of gastrin release by secretin in Zollinger-Ellison syndrome.
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Mechanism of association of adenylate cyclase toxin with the surface of Bordetella pertussis: a role for toxin-filamentous haemagglutinin interaction.
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Mechanism of cytokine inhibition of beta-adrenergic agonist stimulation of cyclic AMP in rat cardiac myocytes. Impairment of signal transduction.
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Mechanism of enhanced sensitivity to bradykinin in pertussis toxin-treated fibroblasts: toxin increases bradykinin-stimulated prostaglandin formation.
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Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase.
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Mechanism of impaired beta-adrenoceptor responsiveness in atopic sensitized airway smooth muscle.
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Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid.
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Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C.
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Mechanism of Li inhibition of vasopressin-sensitive adenylate cyclase in cultured renal epithelial cells.
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Mechanism of lipid mobilization associated with cancer cachexia: interaction between the polyunsaturated fatty acid, eicosapentaenoic acid, and inhibitory guanine nucleotide-regulatory protein.
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Mechanism of noradrenaline-induced heterologous desensitization of adenylate cyclase stimulation in rat heart muscle cells: increase in the level of inhibitory G-protein alpha-subunits.
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Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site.
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Mechanism of retinoic acid induced attenuation of PTH action in UMR 106-01 cells.
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Mechanism underlying histamine-induced desensitization of amylase secretion in rat parotid glands.
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Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.
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Mechanisms of action of antisecretory drugs. Studies on isolated canine fundic mucosal cells.
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Mechanisms of impaired beta-adrenergic receptor signaling in G(alphaq)-mediated cardiac hypertrophy and ventricular dysfunction.
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Mechanisms of mastoparan-stimulated surfactant secretion from isolated pulmonary alveolar type 2 cells.
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Mechanisms of opioid delta (delta) and kappa ( kappa) receptors' cardioprotection in ischaemic preconditioning in a rat model of myocardial infarction.
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Mediation by G protein betagamma subunits of the opioid stimulation of adenylyl cyclase activity in rat olfactory bulb.
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Mediation by protein kinases C and A of Go-linked slow responses of enteric neurons to 5-HT.
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Mediation of adenylyl cyclase sensitization by PTX-insensitive GalphaoA, Galphai1, Galphai2 or Galphai3.
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Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte.
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Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone.
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Melatonin signal transduction in hamster brain: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
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Melatonin-induced organelle movement in melanophores is coupled to tyrosine phosphorylation of a high molecular weight protein.
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Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors.
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Membrane Activity and Channel Formation of the Adenylate Cyclase Toxin (CyaA) of Bordetella pertussis in Lipid Bilayer Membranes.
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Membrane depolarization prevents cell invasion by Bordetella pertussis adenylate cyclase toxin.
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Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells.
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Membrane Permeabilization by Bordetella Adenylate Cyclase Toxin Involves Pores of Tunable Size.
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Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?
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Membrane restructuring by Bordetella pertussis adenylate cyclase toxin, a member of the RTX toxin family.
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Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by alpha-cells of islet of Langerhans.
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Mitogenic effects of fibroblast growth factors in cultured fibroblasts. Interaction with the G-protein-mediated signaling pathways.
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Mobilization of intracellular Ca2+ and stimulation of cyclic AMP production by kappa opioid receptors expressed in Xenopus oocytes.
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Modification of the function of pertussis toxin substrate GTP-binding protein by cholera toxin-catalyzed ADP-ribosylation.
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Modulation by islet-activating protein of adenylate cyclase activity in C6 glioma cells.
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Modulation of adenylate cyclase activity of mouse spinal cord-ganglion explants by opioids, serotonin and pertussis toxin.
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Modulation of adenylate cyclase toxin production as Bordetella pertussis enters human macrophages.
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Modulation of cardiac cyclic AMP metabolism by adenosine receptor agonists and antagonists.
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Modulation of invasiveness and catalytic activity of Bordetella pertussis adenylate cyclase by polycations.
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Modulation of muscarinic receptor-mediated adenylate cyclase and phospholipase C responses in rat retina.
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Modulation of Pertussis and Adenylate Cyclase Toxins by Sigma Factor RpoE in Bordetella pertussis.
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Modulation of responsiveness of the adenylate cyclase system in avian chondroprogenitor cells by pertussis toxin, PTH, and PGE2.
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Modulation of sympathetic actions on the heart by opioid receptor stimulation.
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Molecular analysis of the interaction of Bordetella pertussis adenylyl cyclase with fluorescent nucleotides.
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Molecular and cellular analyses of melatonin receptor-mediated cAMP signaling in rat corpus epididymis.
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Molecular cloning and analysis of P. 69, a vir-controlled protein from Bordetella pertussis.
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Molecular mechanisms of adenylyl cyclase desensitization in pregnant rat myometrium following in vivo administration of the beta-adrenergic agonist, isoproterenol.
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Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling.
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Monitoring the conformational changes of an intrinsically disordered peptide using a quartz crystal microbalance.
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Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.
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Mr 40,000 and Mr 39,000 pertussis toxin substrates are increased in surgically denervated dog ventricular myocardium.
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mt(1) Receptor-mediated antiproliferative effects of melatonin on the rat uterine antimesometrial stromal cells.
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Mu type opioid receptors in rat periaqueductal gray-enriched P2 membrane are coupled to G-protein-mediated inhibition of adenylyl cyclase.
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mu-Opioid receptor-mediated reduction of neuronal calcium current occurs via a G(o)-type GTP-binding protein.
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Mu-opioid-receptor-mediated inhibition of the N-type calcium-channel current.
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Multiple approaches to a complete inventory of Pseudomonas syringae pv. tomato DC3000 type III secretion system effector proteins.
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Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.
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Multiple pertussis toxin substrates as candidates for regulatory G proteins of adenylate cyclase coupled to the somatostatin receptor in primary rat astrocytes.
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Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
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Murine model for pertussis vaccine encephalopathy: role of the major histocompatibility complex; antibody to albumin and to Bordetella pertussis and pertussis toxin.
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Muscarine receptors regulating electrically evoked release of acetylcholine in hippocampus are linked to pertussis toxin-sensitive G proteins but not to adenylate cyclase.
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Muscarinic cholinergic inhibition of cyclic AMP accumulation in airway smooth muscle. Role of a pertussis toxin-sensitive protein.
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Muscarinic cholinergic-receptor stimulation of specific GTP hydrolysis related to adenylate cyclase activity in canine cardiac sarcolemma.
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Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics.
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Muscarinic receptors in canine colonic circular smooth muscle. II. Signal transduction pathways.
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Muscarinic receptors in MDCK cells are coupled to multiple messenger systems.
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Muscarinic stimulation of gallbladder epithelium. III. Antagonism of cAMP-mediated effects.
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Mutants in the ptlA-H genes of Bordetella pertussis are deficient for pertussis toxin secretion.
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Mutation in the ?-hairpin of the Bordetella pertussis adenylate cyclase toxin modulates N-lobe conformation in calmodulin.
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NaF and guanine nucleotides modulate adenylate cyclase activity in NG108-15 cells by interacting with both Gs and Gi.
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Naturally occurring opioid receptor agonists stimulate adenylate cyclase activity in rat olfactory bulb.
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Neferine, a bisbenzylisoquinoline alkaloid of Nelumbo nucifera, inhibits glutamate release in rat cerebrocortical nerve terminals through 5-HT1A receptors.
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Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin.
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Neural modulation of the stimulatory regulatory protein of adenylate cyclase in rat brown adipose tissue.
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Neurochemical and behavioural evidence that dopamine D-2 receptors in striatum couple to the Ni regulatory protein and inhibition of cyclic AMP accumulation.
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Neuromodulatory effects of atrial natriuretic peptides correlate with an inhibition of adenylate cyclase but not an activation of guanylate cyclase.
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Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells.
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Neuropeptide Y inhibits cardiac adenylate cyclase through a pertussis toxin-sensitive G protein.
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Neuropeptide Y inhibits forskolin-stimulated adenylate cyclase in bovine adrenal chromaffin cells via a pertussis toxin-sensitive process.
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Neuropeptide Y inhibits renin release by a pertussis toxin-sensitive mechanism.
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Neuropeptide Y inhibits spontaneous alpha-melanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells.
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Neuropeptide Y reduces macromolecule permeability of coronary endothelial monolayers.
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Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils.
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Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis.
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Nicotine-induced antinociception in mice: role of G-proteins and adenylate cyclase.
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NMR and circular dichroic studies on the solution conformation of a synthetic peptide derived from the calmodulin-binding domain of Bordetella pertussis adenylate cyclase.
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Non-steady state kinetic analysis of the regulation of adenylate cyclase by GTP-binding proteins.
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Norepinephrine, acting via adenylate cyclase, inhibits melatonin output but does not phase-shift the pacemaker in cultured chick pineal cells.
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Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cepsilon.
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Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
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Nucleotide sequence of the Bacillus anthracis edema factor gene (cya): a calmodulin-dependent adenylate cyclase.
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Nucleotidyl cyclase activity of particulate guanylyl cyclase A: comparison with particulate guanylyl cyclases E and F, soluble guanylyl cyclase and bacterial adenylyl cyclases CyaA and edema factor.
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Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution.
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On the selectivity of the G?q inhibitor UBO-QIC: A comparison with the G?i inhibitor pertussis toxin.
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Ontogenesis of physiological responsiveness and guanine nucleotide sensitivity of cardiac muscarinic receptors during chick embryonic development.
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Ontogeny of beta-adrenergic receptor-mediated cyclic AMP generating system in primary cultured neurons.
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Oocyte adenylyl cyclase contains Ni, yet the guanine nucleotide-dependent inhibition by progesterone is not sensitive to pertussis toxin.
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Opioid inhibition of adenylyl cyclase in membranes from pertussis toxin-treated NG108-15 cells.
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Opioid mu, delta, and kappa receptor-induced activation of phospholipase C-beta 3 and inhibition of adenylyl cyclase is mediated by Gi2 and G(o) in smooth muscle.
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Opioid receptor agonists activate pertussis toxin-sensitive G proteins and inhibit adenylyl cyclase in canine cardiac sarcolemma.
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Opioid receptor and calcium channel regulation of adenylyl cyclase, modulated by GM1, in NG108-15 cells: competitive interactions.
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Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes.
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Opioid-induced adenylyl cyclase supersensitization in human embryonic kidney 293 cells requires pertussis toxin-sensitive G proteins other than G(i1) and G(i3).
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Oxytocin Downregulates the CaV1.2 L-Type Ca2+ Channel via Gi/cAMP/PKA/CREB Signaling Pathway in Cardiomyocytes.
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Palmitoylation of human endothelinB. Its critical role in G protein coupling and a differential requirement for the cytoplasmic tail by G protein subtypes.
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Pancreastatin activates pertussis toxin-sensitive guanylate cyclase and pertussis toxin-insensitive phospholipase C in rat liver membranes.
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PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.
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Paradoxical antagonism of PACAP receptor signaling by VIP in Xenopus oocytes via the type-C natriuretic peptide receptor.
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Peptide YY receptors in the proximal tubule PKSV-PCT cell line derived from transgenic mice. Relation with cell growth.
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Peptidergic modulation of G-protein coupled cyclic-AMP accumulation in the rat caudate nucleus.
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Permeabilization in a cerebral endothelial barrier model by pertussis toxin involves the PKC effector pathway and is abolished by elevated levels of cAMP.
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Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract.
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Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools.
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Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis.
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Pertussis toxin and the adenylate cyclase toxin from Bordetella pertussis activate human monocyte-derived dendritic cells and dominantly inhibit cytokine production through a cAMP-dependent pathway.
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Pertussis toxin attenuates 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes.
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Pertussis toxin attenuates angiotensin II-induced vasoconstriction and inhibition of renin release.
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Pertussis toxin attenuates atrial natriuretic factor-mediated inhibition of adenylate cyclase. Involvement of inhibitory guanine nucleotide regulatory protein.
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Pertussis toxin attenuates D2 inhibition and enhances D1 stimulation of adenylate cyclase by dopamine in rat striatum.
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Pertussis toxin blocks a late inhibitory postsynaptic potential in hippocampal CA3 neurons.
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Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra.
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Pertussis toxin blocks melatonin-induced inhibition of forskolin-stimulated adenylate cyclase activity in the chick brain.
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Pertussis toxin blocks somatostatin inhibition of calcium mobilization and reduces the affinity of somatostatin receptors for agonists.
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Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum.
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Pertussis toxin blocks the outward currents evoked by opiate and alpha 2-agonists in locus coeruleus neurons.
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Pertussis toxin blocks the somatostatin-induced inhibition of growth hormone release and adenosine 3',5'-monophosphate accumulation.
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Pertussis toxin can distinguish the augmentary effect elicited by epidermal growth factor from that of phorbol ester on luteal adenylate cyclase activity.
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Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors.
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Pertussis toxin distinguishes between muscarinic receptor-mediated inhibition of adenylate cyclase and stimulation of phosphoinositide hydrolysis in Flow 9000 cells.
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Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization.
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Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats.
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Pertussis toxin enhances the beta-adrenergic and blocks the alpha 2-adrenergic regulation of renin secretion in renal cortical slices.
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Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.
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Pertussis toxin inhibits alpha 2-adrenoceptor-mediated inhibition of adenylate cyclase without affecting muscarinic regulation of [Ca2+]i or inositol phosphate generation in SH-SY5Y human neuroblastoma cells.
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Pertussis toxin inhibits cAMP-induced desensitization of adenylate cyclase in Dictyostelium discoideum.
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Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries.
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Pertussis toxin inhibits negative inotropic and negative chronotropic muscarinic cholinergic effects on the heart.
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Pertussis toxin inhibits stimulated motility independently of the adenylate cyclase pathway in human melanoma cells.
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Pertussis toxin lesioning of the nucleus caudate-putamen attenuates adenylate cyclase inhibition and alters neuronal electrophysiological activity.
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Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91.
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Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.
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Pertussis toxin prevents homologous desensitization of adenylate cyclase in cultured renal epithelial cells.
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Pertussis toxin reversal of the antilipolytic action of insulin in rat adipocytes in the presence of forskolin does not involve cyclic AMP.
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Pertussis toxin reverses adenosine receptor-mediated inhibition of renin secretion in rat renal cortical slices.
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Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase.
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Pertussis toxin reverses prostaglandin E2- and somatostatin-induced inhibition of rat parietal cell H(+)-production.
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Pertussis toxin reverses the inhibition of the adenylyl cyclase system by khellin in HeLa cells.
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Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in GH3 cells.
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Pertussis toxin stimulates cholecystokinin-induced cyclic AMP formation but is without effect on secretagogue-induced calcium mobilization in exocrine pancreas.
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Pertussis toxin stimulates the secretion of [Met5]-enkephalin and the expression of proenkephalin A mRNA in bovine adrenal medullary chromaffin cells.
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Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.
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Pertussis toxin treatment blocks hyperpolarization by muscarinic agonists in chick atrium.
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Pertussis toxin treatment in vivo is associated with a decline in G-protein beta-subunits.
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Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
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Pertussis toxin treatment prevents 5-HT(5a) receptor-mediated inhibition of cyclic AMP accumulation in rat C6 glioma cells.
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Pertussis toxin-catalyzed ADP-ribosylation of adenylate cyclase. Effects of guanyl nucleotides and rhodopsin.
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Pertussis toxin-catalyzed ADP-ribosylation: effects on the coupling of inhibitory receptors to the adenylate cyclase system.
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Pertussis toxin-mediated ADP-ribosylation of rabbit luteal Gi uncouples enkephalin inhibition of adenylyl cyclase.
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Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells.
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Pertussis toxin-sensitive melatonin receptors negatively coupled to adenylate cyclase associated with cultured human and rat retinal pigment epithelial cells.
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Pertussis toxin-treated dog: a whole animal model of impaired inhibitory regulation of adenylate cyclase.
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Pertussis whole cell vaccine: relation between intracerebral protection in mice and antibody response to pertussis toxin, filamentous hemagglutinin and adenylate cyclase.
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Pertussis-toxin insensitive enkephalin inhibition of adenylyl cyclase in lacrimal acinar cells.
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Pharmacological and biochemical characterization of dopamine receptors mediating stimulation of a high affinity GTPase in rat striatum.
Whooping Cough
Pharmacological characterization of the "silent" 5-hydroxytryptamine1B-like receptors of rabbit ear artery.
Whooping Cough
Pharmacological characterization of the adenylate cyclase-coupled adenosine receptor in isolated guinea pig atrial myocytes.
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Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system.
Whooping Cough
Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells.
Whooping Cough
Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action.
Whooping Cough
Phorbol ester modulation of cyclic AMP accumulation in a primary culture of rat aortic smooth muscle cells.
Whooping Cough
Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells.
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Phorbol ester-induced inhibition of the beta-adrenergic system in pulmonary endothelium: role of a pertussis toxin-sensitive protein.
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Phospholipase A activity of adenylate cyclase toxin mediates translocation of its adenylate cyclase domain.
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Phospholipids regulate growth and function of MDCK cells in hormonally defined serum free medium.
Whooping Cough
Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells.
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Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis.
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Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.
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Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
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Pituitary adenylate cyclase polypeptide (PACAP) stimulates cyclic AMP formation in pituitary fibroblasts and 3T3 tumor fibroblasts: lack of enhancement by protein kinase C activation.
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Pituitary cell line GH3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells.
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PKC modulation of inhibitory coupling of angiotensin II receptors with adenylate cyclase in lactotroph cells.
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Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis.
Whooping Cough
Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells.
Whooping Cough
Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: role of voltage and pH.
Whooping Cough
Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8(+) and CD4(+) T cells.
Whooping Cough
Pore-forming and enzymatic activities of Bordetella pertussis adenylate cyclase toxin synergize in promoting lysis of monocytes.
Whooping Cough
Positive inotropism induced by androgens in isolated left atrium of rat: evidence for a cAMP-dependent transcriptional mechanism.
Whooping Cough
Positive vs. negative inotropic effects of carbachol in avian atrial muscle: role of Ni-like protein.
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Possible involvement of a GTP-binding protein in a late event during endogenous ganglioside-modulated cellular proliferation.
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Possible involvement of pertussis toxin substrates (Gi, Go) in desipramine-induced refractoriness of adenylate cyclase in cerebral cortices of rats.
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Possible involvement of pertussis toxin-sensitive G proteins and D2 dopamine receptors in the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex.
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Post-translational acylation controls the folding and functions of the CyaA RTX toxin.
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Potent and cooperative feedback inhibition of adenylate cyclase activity by calcium in pituitary-derived GH3 cells.
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Potentiation of NMDA receptor-mediated transmission in turtle cerebellar granule cells by activation of metabotropic glutamate receptors.
Whooping Cough
Prejunctional alpha 2-adrenoceptors and adenylyl cyclase regulation in the rabbit iris-ciliary body.
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Presence of a functional inhibitory GTP-binding regulatory component, Gi, linked to adenylate cyclase in adipocytes of ob/ob mice.
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Prevention of alpha 2-adrenergic inhibition on ADH action by pertussis toxin in rabbit CCT.
Whooping Cough
Progesterone inhibition of Xenopus oocyte adenylate cyclase is not mediated via the Bordetella pertussis toxin substrate.
Whooping Cough
Prokaryotic adenylate cyclase toxin stimulates anterior pituitary cells in culture.
Whooping Cough
Prolactin inhibits hCG-stimulated steroidogenesis and cAMP accumulation, possibly by increasing phosphodiesterase activity, in rat granulosa cell cultures.
Whooping Cough
Properties of delta opioid receptor in neuroblastoma NS20Y: receptor activation and neuroblastoma proliferation.
Whooping Cough
Properties of muscarinic-stimulated adenylate cyclase activity in rat olfactory bulb.
Whooping Cough
Prostaglandin E receptors in bovine adrenal medulla are coupled to adenylate cyclase via Gi and to phosphoinositide metabolism in a pertussis toxin-insensitive manner.
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Prostaglandin E2 receptors in the heart are coupled to inhibition of adenylyl cyclase via a pertussis toxin sensitive G protein.
Whooping Cough
Prostaglandin F2 alpha and alpha-adrenergic agonists regulate parathyroid cell function via the inhibitory guanine nucleotide regulatory protein.
Whooping Cough
Prostaglandin receptors in NIH 3T3 cells: coupling of one receptor to adenylate cyclase and of a second receptor to phospholipase C.
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Prostaglandin-concentration-dependent desensitization of adenylate cyclase in human erythroleukaemia (HEL) cells is abolished by pertussis toxin and enhanced by induction by dimethyl sulphoxide.
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Prostaglandin-sensitive adenylyl cyclase of cultured preadipocytes and mature adipocytes of the rat: probable role of Gi in determination of stimulatory or inhibitory action.
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Prostaglandins and the urinary concentrating defect in potassium-depleted rabbits.
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Prostaglandins inhibit proliferation of the murine P815 mastocytoma by decreasing cytoplasmic free calcium levels [( Ca+2]i).
Whooping Cough
Prostanoid inhibition of canine parietal cells: mediation by the inhibitory guanosine triphosphate-binding protein of adenylate cyclase.
Whooping Cough
Protective activity of Bordetella adenylate cyclase-hemolysin against bacterial colonization.
Whooping Cough
Protective role of adenylate cyclase in the context of a live pertussis vaccine candidate.
Whooping Cough
Protein intrinsic viscosity determination with the Viscosizer TD instrument: reaching beyond the initially expected applications.
Whooping Cough
Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.
Whooping Cough
Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.
Whooping Cough
Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.
Whooping Cough
Protein kinase C differentially modulates PTH- and PGE2-sensitive adenylate cyclase in osteoblast-like cells.
Whooping Cough
Protein kinase C regulation of the adenylyl cyclase system in rat prostatic epithelium.
Whooping Cough
Protein kinase C stimulates adenylate cyclase activity in prolactin-secreting rat adenoma (GH4C1) pituicytes by inactivating the inhibitory GTP-binding protein Gi.
Whooping Cough
Protein kinase regulation of muscarinic receptor signalling in colonic smooth muscle.
Whooping Cough
Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently.
Whooping Cough
Protein-protein interaction between Bacillus stearothermophilus tyrosyl-tRNA synthetase subdomains revealed by a bacterial two-hybrid system.
Whooping Cough
Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins which involves regulation of bacterial virulence traits.
Whooping Cough
PTH elevates inositol polyphosphates and diacylglycerol in a rat osteoblast-like cell line.
Whooping Cough
Purification and assay of cell-invasive form of calmodulin-sensitive adenylyl cyclase from Bordetella pertussis.
Whooping Cough
Purification and characterization of a calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
Whooping Cough
Purification and characterization of the heat-labile toxin of Bordetella pertussis.
Whooping Cough
Pyridopyrimidine derivatives as inhibitors of cyclic nucleotide synthesis: Application for treatment of diarrhea.
Whooping Cough
Quantification of potassium levels in cells treated with Bordetella adenylate cyclase toxin.
Whooping Cough
Quantifying Adenylate Cyclase Toxin of Bordetella pertussis in vitro and During Respiratory Infection.
Whooping Cough
Quantitation of adenylate cyclase of Bordetella pertussis by enzyme linked immunosorbent assay.
Whooping Cough
Quantitative mass spectrometry for bacterial protein toxins - a sensitive, specific, high-throughput tool for detection and diagnosis.
Whooping Cough
Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells.
Whooping Cough
Rapid and non-genomic reduction of intracellular [Ca(2+)] induced by aldosterone in human bronchial epithelium.
Whooping Cough
Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.
Whooping Cough
Receptor-mediated inhibition of adenylate cyclase and stimulation of arachidonic acid release in 3T3 fibroblasts. Selective susceptibility to islet-activating protein, pertussis toxin.
Whooping Cough
Recognition of mycobacterial antigens delivered by genetically detoxified Bordetella pertussis adenylate cyclase by T cells from cattle with bovine tuberculosis.
Whooping Cough
Recombinant adenylate cyclase toxin of Bordetella pertussis induces cytotoxic T lymphocyte responses against HLA*0201-restricted melanoma epitopes.
Whooping Cough
Reconstitution of muscarinic cholinergic inhibition of adenylate cyclase activity in homogenates of embryonic chick hearts by membranes of adult chick hearts.
Whooping Cough
Reduced hormone-stimulated adenylate cyclase activity in NIH-3T3 cells expressing the EJ human bladder ras oncogene.
Whooping Cough
Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus.
Whooping Cough
Regulation of adenylyl cyclase, ERK1/2, and CREB by Gz following acute and chronic activation of the delta-opioid receptor.
Whooping Cough
Regulation of endogenous human NPFF2 receptor by neuropeptide FF in SK-N-MC neuroblastoma cell line.
Whooping Cough
Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
Whooping Cough
Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization.
Whooping Cough
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet activation and comparisons with the adenylate cyclase inhibitory protein, Gi.
Whooping Cough
Regulation of Xenopus oocyte meiosis arrest by G protein betagamma subunits.
Whooping Cough
Relationship between the self-incompatibility and cAMP level in Lilium longiflorum.
Whooping Cough
Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.
Whooping Cough
Repeat sequences in the Bordetella pertussis adenylate cyclase toxin can be recognized as alternative carboxy-proximal secretion signals by the Escherichia coli alpha-haemolysin translocator.
Whooping Cough
Requirement for both choleragen and pertussis toxin to obtain maximal activation of adenylate cyclase in cultured cells.
Whooping Cough
Reticulocyte cytosol activator protein: effects on the stimulatory and inhibitory regulatory proteins of adenylate cyclase.
Whooping Cough
Reticulocyte cytosol activator protein: its actions upon the beta adrenergic receptor and the N-proteins of adenylate cyclase.
Whooping Cough
Rhodopsin expressed in Chinese hamster ovary cells regulates adenylyl cyclase activity.
Whooping Cough
Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system.
Whooping Cough
Role for cyclic AMP in the postreceptor control of cytokine-stimulated stromal cell growth factor production.
Whooping Cough
Role of a pertussis toxin sensitive G-protein in mediating the effects of phorbol esters on receptor activated cyclic AMP accumulation in Jurkat cells.
Whooping Cough
Role of adenosine 3',5'-monophosphate and the Ri-receptor Gi-coupled adenylate cyclase inhibitory pathway in the mechanism whereby adrenalectomy increases the adenosine antilipolytic effect in rat fat cells.
Whooping Cough
Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line.
Whooping Cough
Role of Bordetella pertussis RseA in the cell envelope stress response and adenylate cyclase toxin release.
Whooping Cough
Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis.
Whooping Cough
Role of dopamine and indolamine derivatives in the regulation of the sea urchin adenylate cyclase.
Whooping Cough
Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.
Whooping Cough
Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines.
Whooping Cough
Role of G-proteins in ciliary process adenylyl cyclase responses of the albino rabbit eye.
Whooping Cough
Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance.
Whooping Cough
Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.
Whooping Cough
Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.
Whooping Cough
Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.
Whooping Cough
Role of PKC-? in NADPH oxidase-PKC?-Gi? axis dependent inhibition of ?-adrenergic response by U46619 in pulmonary artery smooth muscle cells.
Whooping Cough
Role of PKC?-p38 MAPK-Gi? axis in peroxynitrite-mediated inhibition of ?-adrenergic response in pulmonary artery smooth muscle cells.
Whooping Cough
Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI2 analogues in rat tail artery: Evidence for Gi/o modulation via EP3 receptors.
Whooping Cough
Role of two different guanine nucleotide-binding proteins in the antagonistic modulation of the S-type K+ channel by cAMP and arachidonic acid metabolites in Aplysia sensory neurons.
Whooping Cough
Roles of kappa opioid receptors in cardioprotection against ischemia: the signaling mechanisms.
Whooping Cough
RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion.
Whooping Cough
RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides.
Whooping Cough
Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements and partial purification of two forms.
Whooping Cough
Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis.
Whooping Cough
Secretion of the Bordetella pertussis adenylate cyclase from Escherichia coli containing the hemolysin operon.
Whooping Cough
Secretion-stimulating and secretion-inhibiting hormones stimulate high-affinity pertussis-toxin-sensitive GTPases in membranes of a pituitary cell line.
Whooping Cough
Selective blockage by islet-activating protein, pertussis toxin, of negative signal transduction from receptors to adenylate cyclase.
Whooping Cough
Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.
Whooping Cough
Sensitive genetic screen for protease activity based on a cyclic AMP signaling cascade in Escherichia coli.
Whooping Cough
Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha.
Whooping Cough
Sensitization of endogenous and recombinant adenylate cyclase by activation of D2 dopamine receptors.
Whooping Cough
Sequence variation and conservation in virulence-related genes of Bordetella pertussis isolates from the UK.
Whooping Cough
Sequential activation and environmental regulation of virulence genes in Bordetella pertussis.
Whooping Cough
Shapes of cells spreading on fibronectin: measurement of the stellation of BHK21 cells induced by raising cyclic AMP, and of its reversal by serum and lysophosphatidic acid.
Whooping Cough
Short- and long-term regulation of adenylyl cyclase activity by delta-opioid receptor are mediated by Galphai2 in neuroblastoma N2A cells.
Whooping Cough
Short-term regulation of Na+/K+ adenosine triphosphatase by recombinant human serotonin 5-HT1A receptor expressed in HeLa cells.
Whooping Cough
Signal transduction alterations in GH(1)2C1 rat pituitary tumour cells following treatment with 5-azacytidine.
Whooping Cough
Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney cells.
Whooping Cough
Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein.
Whooping Cough
Signal transduction pathway for IL-1. Involvement of a pertussis toxin-sensitive GTP-binding protein in the activation of adenylate cyclase.
Whooping Cough
Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling.
Whooping Cough
Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.
Whooping Cough
Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression.
Whooping Cough
Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.
Whooping Cough
Simultaneous Determination of Antibodies to Pertussis Toxin and Adenylate Cyclase Toxin Improves Serological Diagnosis of Pertussis.
Whooping Cough
Site I Inactivation Impacts Calmodulin Calcium Binding and Activation of Bordetella pertussis Adenylate Cyclase Toxin.
Whooping Cough
Site of pertussis toxin-induced ADP-ribosylation on Gi is critical for receptor modulation of GDP interaction with Gi.
Whooping Cough
Site-directed mutagenesis of lysine 58 in a putative ATP-binding domain of the calmodulin-sensitive adenylate cyclase from Bordetella pertussis abolishes catalytic activity.
Whooping Cough
Sodium and potassium regulation of guanine nucleotide-stimulated adenylate cyclase in brain.
Whooping Cough
Solubilization and immunopurification of a somatostatin receptor from the human gastric tumoral cell line HGT-1.
Whooping Cough
Soluble adenylate cyclase from the culture medium of Bordetella pertussis: purification and characterization.
Whooping Cough
Somatocrinin stimulates adenylate cyclase-Ns regulatory subunit in a GH3 cell-line: comparison with VIP.
Whooping Cough
Somatostatin inhibition of adenylate cyclase activity in different brain areas.
Whooping Cough
Somatostatin inhibition of anterior pituitary adenylate cyclase activity: different sensitivity between male and female rats.
Whooping Cough
Somatostatin inhibits follicle-stimulating hormone-induced adenylyl cyclase activity and proliferation in immature porcine Sertoli cell via sst2 receptor.
Whooping Cough
Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase.
Whooping Cough
Somatostatin inhibits stem cell factor messenger RNA expression by Sertoli cells and stem cell factor-induced DNA synthesis in isolated seminiferous tubules.
Whooping Cough
Somatostatin modulation of adenosine receptor coupled G-protein subunits in the caudate nucleus of the rat.
Whooping Cough
Somatostatin receptors on pituitary somatotrophs, thyrotrophs, and lactotrophs: pharmacological evidence for loose coupling to adenylate cyclase.
Whooping Cough
Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores.
Whooping Cough
Specific inhibition of FSH-stimulated cAMP accumulation by delta 9-tetrahydrocannabinol in cultures of rat Sertoli cells.
Whooping Cough
Specific isoprenyl group linked to transducin gamma-subunit is a determinant of its unique signaling properties among G-proteins.
Whooping Cough
SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist.
Whooping Cough
Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.
Whooping Cough
Stable inhibition of adenylate cyclase by muscarinic agonist in rat parotid gland: effects of neomycin and pertussis toxin.
Whooping Cough
Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins.
Whooping Cough
Stimulation and inhibition of adenylyl cyclases mediated by distinct regulatory proteins.
Whooping Cough
Stimulation and inhibition of rat basophilic leukemia cell adenylate cyclase by forskolin.
Whooping Cough
Stimulation of Bordetella pertussis adenylate cyclase toxin intoxication by its hemolysin domain.
Whooping Cough
Stimulation of rat pancreatic tumoral AR4-2J cell proliferation by pituitary adenylate cyclase-activating peptide.
Whooping Cough
Stimulation of type II adenylyl cyclase by chemoattractant formyl peptide and C5a receptors.
Whooping Cough
Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins.
Whooping Cough
Structural and functional characterization of an essential RTX subdomain of Bordetella pertussis adenylate cyclase toxin.
Whooping Cough
Structural and functional properties of a 69-kilodalton outer membrane protein of Bordetella pertussis.
Whooping Cough
Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes.
Whooping Cough
Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.
Whooping Cough
Structural characterization by nuclear magnetic resonance spectroscopy of a genetically engineered high-affinity calmodulin-binding peptide derived from Bordetella pertussis adenylate cyclase.
Whooping Cough
Structural consequences of divalent metal binding by the adenylyl cyclase toxin of Bordetella pertussis.
Whooping Cough
Structural flexibility of the calmodulin-binding locus in Bordetella pertussis adenylate cyclase. Reconstitution of catalytically active species from fragments or inactive forms of the enzyme.
Whooping Cough
Structural homology between virulence-associated bacterial adenylate cyclases.
Whooping Cough
Structure of a cannabinoid receptor and functional expression of the cloned cDNA.
Whooping Cough
Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells.
Whooping Cough
Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.
Whooping Cough
Structure-function studies of the adenylate cyclase toxin of Bordetella pertussis and the leukotoxin of Pasteurella haemolytica by heterologous C protein activation and construction of hybrid proteins.
Whooping Cough
Studies on the mechanisms of signalling and inhibition by pertussis toxin of fibroblast growth factor-stimulated mitogenesis in Balb/c 3T3 cells.
Whooping Cough
Study of the functional organization of a novel adenylate cyclase signaling mechanism of insulin action.
Whooping Cough
Substantial gaps in knowledge of Bordetella pertussis antibody and T cell epitopes relevant for natural immunity and vaccine efficacy.
Whooping Cough
Supersensitivity to mu-opioid receptor-mediated inhibition of the adenylyl cyclase pathway involves pertussis toxin-resistant Galpha protein subunits.
Whooping Cough
Supersensitization of the adenylyl cyclase system in Chinese hamster ovary cells co-expressing cloned opioid receptors and Gz, a PTX-insensitive G protein.
Whooping Cough
Suppression of leukotriene synthesis in human leukocytes by a urea extract of Bordetella pertussis: evidence for mediation by adenylate cyclase toxin.
Whooping Cough
Suppression of platelet aggregation by Bordetella pertussis adenylate cyclase toxin.
Whooping Cough
Suppression of serum antibody responses by pertussis toxin after respiratory tract colonization by Bordetella pertussis and identification of an immunodominant lipoprotein.
Whooping Cough
Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussis.
Whooping Cough
Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism.
Whooping Cough
Susceptibility of primary human airway epithelial cells to Bordetella pertussis adenylate cyclase toxin in two- and three-dimensional culture conditions.
Whooping Cough
Synergistic interaction of muscarinic and opioid receptors with GS-linked neurotransmitter receptors to stimulate adenylyl cyclase activity of rat olfactory bulb.
Whooping Cough
Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells.
Whooping Cough
Synthesis and characterization of fluorescently labeled bovine brain G protein subunits.
Whooping Cough
Synthesis and characterization of tethered lipid assemblies for membrane protein reconstitution (Review).
Whooping Cough
Synthesis and secretion of Bordetella pertussis adenylate cyclase as a 200-kilodalton protein.
Whooping Cough
Synthesis of ?-Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases.
Whooping Cough
Synthetic alpha-thrombin receptor peptides activate G protein-coupled signaling pathways but are unable to induce mitogenesis.
Whooping Cough
Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes.
Whooping Cough
Synthetic peptides corresponding to human follicle-stimulating hormone (hFSH)-beta-(1-15) and hFSH-beta-(51-65) induce uptake of 45Ca++ by liposomes: evidence for calcium-conducting transmembrane channel formation.
Whooping Cough
Targeted mutations that ablate either the adenylate cyclase or hemolysin function of the bifunctional cyaA toxin of Bordetella pertussis abolish virulence.
Whooping Cough
Temperature Accelerated Molecular Dynamics with Soft-Ratcheting Criterion Orients Enhanced Sampling by Low-Resolution Information.
Whooping Cough
Temperature-accelerated molecular dynamics gives insights into globular conformations sampled in the free state of the AC catalytic domain.
Whooping Cough
The 5-HT4 receptor antagonist ML10375 inhibits the constitutive activity of human 5-HT4(c) receptor.
Whooping Cough
The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes.
Whooping Cough
The action of pertussis toxin on heart adenylate cyclase and lipolysis in the parametrial adipose tissue of the rat.
Whooping Cough
The activation of human platelets mediated by anti-human platelet p24/CD9 monoclonal antibodies.
Whooping Cough
The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro.
Whooping Cough
The adenylate cyclase of Bordetella pertussis: a vector to target antigen presenting cells.
Whooping Cough
The adenylate cyclase toxin contributes to the survival of Bordetella pertussis within human macrophages.
Whooping Cough
The adenylate cyclase toxin from Bordetella pertussis--a novel promising vehicle for antigen delivery to dendritic cells.
Whooping Cough
The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18).
Whooping Cough
The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling.
Whooping Cough
The biochemical effect of the naturally occurring Trp64-->Arg mutation on human beta3-adrenoceptor activity.
Whooping Cough
The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse.
Whooping Cough
The C-terminal domain is essential for protective activity of the Bordetella pertussis adenylate cyclase-hemolysin.
Whooping Cough
The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia col.
Whooping Cough
The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli.
Whooping Cough
The Campylobacter jejuni CiaC virulence protein is secreted from the flagellum and delivered to the cytosol of host cells.
Whooping Cough
The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells.
Whooping Cough
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.
Whooping Cough
The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status.
Whooping Cough
The coupling of pertussis toxin-sensitive G proteins to phospholipase A2 and adenylyl cyclase in CHO cells expressing bovine rhodopsin.
Whooping Cough
The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.
Whooping Cough
The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells.
Whooping Cough
The effect of growth conditions on adenylate cyclase activity and virulence-related properties of Bordetella pertussis.
Whooping Cough
The effect of streptozotocin diabetes on the vasoactive intestinal peptide receptor/effector system in membranes from rat ventral prostate.
Whooping Cough
The endocannabinoid noladin ether acts as a full agonist at human CB2 cannabinoid receptors.
Whooping Cough
The glutamate-receptor linked cGMP cascade of retinal on-bipolar cells is pertussis and cholera toxin-sensitive.
Whooping Cough
The GTP-binding regulatory proteins, Gs and G(i), are altered in erythrocyte membranes of patients with ischemic heart disease resulting from coronary atherosclerosis.
Whooping Cough
The H-L subgroup of guinea-pig cardiac M2 receptors (M2 beta) regulates inositol phosphate formation.
Whooping Cough
The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.
Whooping Cough
The human 5-ht5A receptor couples to Gi/Go proteins and inhibits adenylate cyclase in HEK 293 cells.
Whooping Cough
The human and dog 5-HT1D receptors can both activate and inhibit adenylate cyclase in transfected cells.
Whooping Cough
The human chemoattractant complement C5a receptor inhibits cyclic AMP accumulation through Gi and Gz proteins.
Whooping Cough
The human delta opioid receptor activates G(i1)alpha more efficiently than G(o1)alpha.
Whooping Cough
The human gonadotropin-inhibitory hormone ortholog RFamide-related peptide-3 suppresses gonadotropin-induced progesterone production in human granulosa cells.
Whooping Cough
The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism.
Whooping Cough
The inhibitory guanine nucleotide-binding protein (Ni) purified from bovine brain is a high affinity GTPase.
Whooping Cough
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.
Whooping Cough
The inhibitory guanine nucleotide-binding regulatory subunit of adenylate cyclase has an adenylate cyclase-independent modulatory effect on ACTH secretion from mouse pituitary tumor cells.
Whooping Cough
The interaction of Ca2+ with the calmodulin-sensitive adenylate cyclase from Bordetella pertussis.
Whooping Cough
The interaction of nucleotides with pertussis toxin. Direct evidence for a nucleotide binding site on the toxin regulating the rate of ADP-ribosylation of Ni, the inhibitory regulatory component of adenylyl cyclase.
Whooping Cough
The invasive adenylate cyclase of Bordetella pertussis. Intracellular localization and kinetics of penetration into various cells.
Whooping Cough
The invasive adenylate cyclase of Bordetella pertussis. Properties and penetration kinetics.
Whooping Cough
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure.
Whooping Cough
The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein.
Whooping Cough
The membrane-bound spermatozoal adenylyl cyclase system does not share coupling characteristics with somatic cell adenylyl cyclases.
Whooping Cough
The morphological changes in cultured cells caused by Bordetella pertussis adenylate cyclase toxin.
Whooping Cough
The negative inotropic effect of neuropeptide Y on the ventricular cardiomyocyte.
Whooping Cough
The neuropeptide pituitary adenylate cyclase activating polypeptide modulates Ca2+ and pro-inflammatory functions in human monocytes through the G protein-coupled receptors VPAC-1 and formyl peptide receptor-like 1.
Whooping Cough
The new cardiotonic agent sulmazole is an A1 adenosine receptor antagonist and functionally blocks the inhibitory regulator, Gi.
Whooping Cough
The peripheral cannabinoid receptor: adenylate cyclase inhibition and G protein coupling.
Whooping Cough
The presence of atrial-natriuretic-factor receptors of ANF-R2 subtype in rat platelets. Coupling to adenylate cyclase/cyclic AMP signal-transduction system.
Whooping Cough
The regulation of adenylate cyclase by guanine nucleotides in Dictyostelium discoideum membranes.
Whooping Cough
The relationship between 3',5'-cyclic adenosine monophosphate and calcium in mediating follicle-stimulating hormone signal transduction in Sertoli cells.
Whooping Cough
The role of histidine 63 in the catalytic mechanism of Bordetella pertussis adenylate cyclase.
Whooping Cough
The somatostatin receptors SSTR1 and SSTR2 are coupled to inhibition of adenylyl cyclase in Chinese hamster ovary cells via pertussis toxin-sensitive pathways.
Whooping Cough
The stimulatory and inhibitory guanine nucleotide-binding proteins of adenylate cyclase in erythrocytes from patients with pseudohypoparathyroidism type I.
Whooping Cough
The thrombin receptor in adrenal medullary microvascular endothelial cells is negatively coupled to adenylyl cyclase through a Gi protein.
Whooping Cough
The Virulence Factors of Bordetella pertussis: Talented Modulators of Host Immune Response.
Whooping Cough
Therapy of murine tumors with recombinant Bordetella pertussis adenylate cyclase carrying a cytotoxic T cell epitope.
Whooping Cough
Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C.
Whooping Cough
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets.
Whooping Cough
Thyrotropin effect on the availability of Ni regulatory protein in FRTL-5 rat thyroid cells to ADP-ribosylation by pertussis toxin.
Whooping Cough
Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity.
Whooping Cough
Towards selective inhibitors of adenylyl cyclase toxin from Bordetella pertussis.
Whooping Cough
Toxicity tests on native and recombinant Bordetella pertussis adenylate cyclase toxin preparations.
Whooping Cough
Transcriptional responses of murine macrophages to the adenylate cyclase toxin of Bordetella pertussis.
Whooping Cough
Transforming growth factor beta enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells.
Whooping Cough
Transforming growth factor-beta 1 regulation of signal transduction in two renal epithelial cell lines.
Whooping Cough
Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.
Whooping Cough
Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells.
Whooping Cough
Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis.
Whooping Cough
Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin.
Whooping Cough
Treatment of intact striatal neurones with cholera toxin or 8-bromoadenosine 3',5'-(cyclic)phosphate decreases the ability of pertussis toxin to ADP-ribosylate the alpha-subunits of inhibitory and other guanine-nucleotide-binding regulatory proteins, Gi and Go. Evidence for two distinct mechanisms.
Whooping Cough
Treatment with pertussis toxin does not prevent central effects of eel calcitonin.
Whooping Cough
Tricyclic antidepressants inhibit Ca(2+)-activated K(+)-efflux in cultured spinal cord neurons.
Whooping Cough
tTGase/G alpha h protein expression inhibits adenylate cyclase activity in Balb-C 3T3 fibroblasts membranes.
Whooping Cough
Tumor necrosis factor alpha inhibits collagen alpha 1(I) gene expression in rat hepatic stellate cells through a G protein.
Whooping Cough
Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors.
Whooping Cough
Two distinct Gi-proteins mediate formyl peptide receptor signal transduction in human leukemia (HL-60) cells.
Whooping Cough
Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes.
Whooping Cough
Up-regulation of beta 2-adrenergic receptors in previously transplanted, denervated nonfailing human hearts.
Whooping Cough
Uptake and intracellular survival of Bordetella pertussis in human macrophages.
Whooping Cough
Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.
Whooping Cough
Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor.
Whooping Cough
Use of pertussis toxin to investigate the mechanism of action of prostaglandin F2 alpha on the corpus luteum in sheep.
Whooping Cough
Vasopressin V1 receptors on the principal cells of the rabbit cortical collecting tubule. Stimulation of cytosolic free calcium and inositol phosphate production via coupling to a pertussis toxin substrate.
Whooping Cough
Virulence dependent and independent regulation of the Bordetella pertussis cya operon.
Whooping Cough
Virulence of a Bordetella pertussis strain expressing a mutant adenylyl cyclase with decreased calmodulin affinity.
Whooping Cough
[A polyvalent complex of Bordetella pertussis antigens as the basis for an acellular pertussis vaccine]
Whooping Cough
[Development and optimization of an in-house PCR method for molecular diagnosis of pertussis].
Whooping Cough
[Evaluation of G(i/o) protein signal transduction pathway in cardioprotection of hypoxic preconditioning]
Whooping Cough
[Localization of segments in the Gs protein interacting with adenylate cyclase using a Gs/G0-chimera]
Whooping Cough
[Pertussis toxin stimulates brain adenyl cyclase and induces ADP ribosylation of a 40,000 dalton membrane protein]
Whooping Cough
[Structural organization of a segment of chromosome, containing the vir gene of Bordetella pertussis]
Whooping Cough
[The discovery of neuromedin U and its pivotal role in the central regulation of energy homeostasis].
Wolfram Syndrome
RETRACTION: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
Wolfram Syndrome
Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion.
Xeroderma Pigmentosum
Melanocyte-stimulating hormone directly enhances UV-Induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism.
Yersinia Infections
[Prostaglandins and cyclic nucleotides in the gastrointestinal form of yersiniosis]
Zika Virus Infection
Variations in maternal adenylate cyclase genes are associated with congenital Zika syndrome in a cohort from Northeast, Brazil.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Q7A2D9_NOSS1
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
859
0
96738
TrEMBL
-
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
CyaB1 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaB1 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
additional information
CyaB1 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Linder, J.U.
Class III adenylyl cyclases: molecular mechanisms of catalysis and regulation
Cell. Mol. Life Sci.
63
1736-1751
2006
Bacillus anthracis, Bordetella pertussis, Saccharomyces cerevisiae, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chloroflexus aurantiacus, Dictyostelium discoideum, Drosophila melanogaster, Escherichia coli, Euglena gracilis, Mus musculus, Myxococcus xanthus, Pseudomonas aeruginosa, Rattus norvegicus, Sinorhizobium meliloti, Schizosaccharomyces pombe, Arthrospira platensis, Trypanosoma brucei, Ustilago maydis, Yersinia enterocolitica, Mycobacterium tuberculosis (P9WQ35), Nostoc sp. PCC 7120 = FACHB-418 (Q7A2D9), Nostoc sp. PCC 7120 = FACHB-418 (Q8YMH0), Nostoc sp. PCC 7120 = FACHB-418 (Q8YVS0), Mycobacterium tuberculosis H37Rv (P9WQ35)
brenda
EXTERNAL LINKS (specific for EC-Number 4.6.1.1)
Transporter Classification Database (TCDB): 8.A.85.1.4
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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