Disease on EC 4.4.1.5 - lactoylglutathione lyase
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Adrenal Hyperplasia, Congenital
Extended MHC haplotypes in 21-hydroxylase-deficiency congenital adrenal hyperplasia: shared genotypes in unrelated patients.
Adrenal Hyperplasia, Congenital
Heterozygotes and cryptic patients in families of patients with congenital adrenal hyperplasia (21-hydroxylase deficiency). HLA and glyoxalase I typing and hormonal studies.
Adrenal Hyperplasia, Congenital
Sharing of MHC haplotypes among apparently unrelated patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Alzheimer Disease
20S proteasome and glyoxalase 1 activities decrease in erythrocytes derived from Alzheimer's disease patients.
Alzheimer Disease
Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains.
Alzheimer Disease
HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type.
Alzheimer Disease
Levels of Receptor for Advanced Glycation End Products and Glyoxalase-1 in the Total Circulating Extracellular Vesicles from Mild Cognitive Impairment and Different Stages of Alzheimer's Disease Patients.
Alzheimer Disease
Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer's disease.
Anemia, Hemolytic
Major histocompatibility complex markers in patients with nomifensine-induced immune hemolytic anemia.
Asthma
Absolute Quantification of Allergen Glb33 in Rice by Liquid Chromatography-Mass Spectrometry using Two Isotope-Labeled Standard Peptides.
Atherosclerosis
A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice.
Atherosclerosis
Dicarbonyl stress in the absence of hyperglycemia increases endothelial inflammation and atherogenesis similar to that observed in diabetes.
Atherosclerosis
Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice.
Atherosclerosis
Gender difference in glyoxalase 1 activity of atherosclerotic carotid artery lesions.
Atherosclerosis
Reduced glyoxalase 1 activity in carotid artery plaques of nondiabetic patients with increased hemoglobin A1c level.
Brain Diseases
Enhancement of glyoxalase 1, a polyfunctional defense enzyme, by quercetin in the brain in streptozotocin-induced diabetic rats.
Breast Neoplasms
A possible regulatory role of 17beta-estradiol and tamoxifen on glyoxalase I and glyoxalase II genes expression in MCF7 and BT20 human breast cancer cells.
Breast Neoplasms
Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade.
Breast Neoplasms
Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2.
Breast Neoplasms
Glyoxalase 1 and protein kinase C? as potential therapeutic targets for late-stage breast cancer.
Breast Neoplasms
Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer.
Breast Neoplasms
Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.
Breast Neoplasms
Glyoxalase I Ala111Glu gene polymorphism: No association with breast cancer risk but correlated with absence of progesterone receptor.
Breast Neoplasms
Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative.
Breast Neoplasms
Polymorphisms of the receptor for advanced glycation end products and glyoxalase I and long-term outcome in patients with breast cancer.
Breast Neoplasms
Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy.
Breast Neoplasms
Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer.
Breast Neoplasms
Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells.
Breast Neoplasms
The influence of glyoxalase 1 gene polymorphism on its expression at different stages of breast cancer in Egyptian women.
Breast Neoplasms
Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes.
Breast Neoplasms
Up-regulation of the tumor promoter Glyoxalase-1 indicates poor prognosis in breast cancer.
Carcinogenesis
Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2.
Carcinogenesis
Changes in concentrations of methylglyoxal, D-lactate and glyoxalase activities in liver and plasma of rats fed a 3'-methyl-4-dimethylaminoazobenzene-rich diet.
Carcinogenesis
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis.
Carcinogenesis
Glo1 genetic amplification as a potential therapeutic target in hepatocellular carcinoma.
Carcinogenesis
Inhibitory Effect of Isoflavones from Erythrina poeppigiana on the Growth of HL-60 Human Leukemia Cells through Inhibition of Glyoxalase I.
Carcinoma
Discovery of a nanomolar inhibitor of the human glyoxalase-I enzyme using structure-based poly-pharmacophore modelling and molecular docking.
Carcinoma
Glyoxalase 1 as a candidate for indicating the metastatic potential of SN12C human renal cell carcinoma cell clones.
Carcinoma
Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma.
Carcinoma
Glyoxalase 1, regulated by LncRNA MALAT1, promotes malignant development of esophageal squamous cell carcinoma.
Carcinoma
Glyoxalase I is differentially expressed in cutaneous neoplasms and contributes to the progression of squamous cell carcinoma.
Carcinoma
Interaction of aldehydes with glyoxalase I and the status of several aldehyde metabolizing enzymes of Ehrlich ascites carcinoma cells.
Carcinoma
Oxidative stress and glyoxalase I activity mediate dicarbonyl toxicity in MCF-7 mamma carcinoma cells and a tamoxifen resistant derivative.
Carcinoma
The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice.
Carcinoma, Hepatocellular
Glyoxalase 1 is up-regulated in hepatocellular carcinoma and is essential for HCC cell proliferation
Carcinoma, Hepatocellular
Glyoxalase 1 is up-regulated in hepatocellular carcinoma and is essential for HCC cell proliferation.
Carcinoma, Hepatocellular
Inhibition of Glyoxalase-I Leads to Reduced Proliferation, Migration and Colony Formation, and Enhanced Susceptibility to Sorafenib in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
The Role of Glyoxalase-I (Glo-I), Advanced Glycation Endproducts (AGEs), and Their Receptor (RAGE) in Chronic Liver Disease and Hepatocellular Carcinoma (HCC).
Carcinoma, Lewis Lung
The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice.
Carcinoma, Renal Cell
Glyoxalase 1 as a candidate for indicating the metastatic potential of SN12C human renal cell carcinoma cell clones.
Carcinoma, Squamous Cell
Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma.
Carcinoma, Squamous Cell
Glyoxalase I is differentially expressed in cutaneous neoplasms and contributes to the progression of squamous cell carcinoma.
Cardiovascular Diseases
Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics.
Cardiovascular Diseases
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
Carotid Artery Diseases
Glyoxalase I and aldose reductase gene polymorphisms and susceptibility to carotid atherosclerosis in type 2 diabetes.
Carotid Stenosis
Reduced glyoxalase 1 activity in carotid artery plaques of nondiabetic patients with increased hemoglobin A1c level.
Chronic Limb-Threatening Ischemia
Glyoxalase-1 Overexpression Reverses Defective Proangiogenic Function of Diabetic Adipose-Derived Stem Cells in Streptozotocin-Induced Diabetic Mice Model of Critical Limb Ischemia.
Colonic Neoplasms
Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway.
Colorectal Neoplasms
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis.
Corneal Dystrophies, Hereditary
Linkage analysis in granular corneal dystrophy (Groenouw I), Schnyder's crystalline corneal dystrophy, and Reis-Bücklers' corneal dystrophy.
Dermatitis, Atopic
Absolute Quantification of Allergen Glb33 in Rice by Liquid Chromatography-Mass Spectrometry using Two Isotope-Labeled Standard Peptides.
Diabetes Complications
C332C genotype of glyoxalase 1 and its association with late diabetic complications.
Diabetes Complications
Flow cytometric analysis of glyoxalase-1 expression in human leukocytes.
Diabetes Complications
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
Diabetes Complications
Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway.
Diabetes Complications
Increased levels of methylglyoxal-metabolizing enzymes in mononuclear and polymorphonuclear cells from insulin-dependent diabetic patients with diabetic complications: aldose reductase, glyoxalase I, and glyoxalase II--a clinical research center study.
Diabetes Complications
Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.
Diabetes Complications
Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase.
Diabetes Complications
Negative association between erythrocyte reduced glutathione concentration and diabetic complications.
Diabetes Complications
The Antidepressant-Like Effects of Hesperidin in Streptozotocin-Induced Diabetic Rats by Activating Nrf2/ARE/Glyoxalase 1 Pathway.
Diabetes Mellitus
Association of glyoxalase I allotypes with Graves' disease and diabetes mellitus.
Diabetes Mellitus
Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients.
Diabetes Mellitus
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
Diabetes Mellitus
Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose.
Diabetes Mellitus
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Diabetes Mellitus, Type 1
HLA-A, B, C, DR antigens, Bf, C4 and glyoxalase I (GLO) polymorphisms in French Basques with insulin-dependent diabetes mellitus (IDDM).
Diabetes Mellitus, Type 1
Increased levels of methylglyoxal-metabolizing enzymes in mononuclear and polymorphonuclear cells from insulin-dependent diabetic patients with diabetic complications: aldose reductase, glyoxalase I, and glyoxalase II--a clinical research center study.
Diabetes Mellitus, Type 2
Association of Two Glyoxalase 1 Gene Polymorphisms with Nephropathy and Retinopathy in Type 2 Diabetes.
Diabetes Mellitus, Type 2
C332C genotype of glyoxalase 1 and its association with late diabetic complications.
Diabetes Mellitus, Type 2
Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes.
Diabetes Mellitus, Type 2
Effect of metformin treatment in patients with type 2 diabetes with respect to glyoxalase 1 activity in atherosclerotic lesions.
Diabetes Mellitus, Type 2
Flow cytometric analysis of glyoxalase-1 expression in human leukocytes.
Diabetes Mellitus, Type 2
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Glyoxalase I and aldose reductase gene polymorphisms and susceptibility to carotid atherosclerosis in type 2 diabetes.
Diabetes Mellitus, Type 2
The combination of loss of glyoxalase1 and obesity results in hyperglycemia.
Diabetic Angiopathies
The characterisation and functional analysis of the human glyoxalase-1 gene using methods of bioinformatics.
Diabetic Cardiomyopathies
Adeno-Associated Viral Transfer of Glyoxalase-1 Blunts Carbonyl and Oxidative Stresses in Hearts of Type 1 Diabetic Rats.
Diabetic Nephropathies
Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality.
Diabetic Nephropathies
Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway.
Diabetic Nephropathies
The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy.
Diabetic Nephropathies
Up-regulation of glyoxalase 1 by mangiferin prevents diabetic nephropathy progression in streptozotocin-induced diabetic rats.
Diabetic Neuropathies
Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients.
Diabetic Neuropathies
Expression of macrophage migration inhibitory factor in footpad skin lesions with diabetic neuropathy.
Diabetic Retinopathy
CANDESARTAN ATTENUATES DIABETIC RETINAL VASCULAR PATHOLOGY BY RESTORING GLYOXALASE-I FUNCTION.
Diabetic Retinopathy
Expression analysis of glyoxalase I gene among patients of diabetic retinopathy.
Diabetic Retinopathy
Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions.
Diabetic Retinopathy
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.
Endometrial Neoplasms
Comment on 'Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression'
Endometrial Neoplasms
Metformin reverses progestin resistance in endometrial cancer cells by downregulating GloI expression.
Endometrial Neoplasms
Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression.
Endometrial Neoplasms
Metformin sensitizes endometrial cancer cells to progestin by targeting TET1 to downregulate glyoxalase I expression.
Endometrial Neoplasms
Response to 'Comment on Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression'
Endometrial Neoplasms
[Expression of glyoxalase I and its effect on cell proliferation and apoptosis in endometrial carcinoma].
Epilepsy
LncRNA NEAT1 affects inflammatory response by targeting miR-129-5p and regulating Notch signaling pathway in epilepsy.
Epilepsy
Role of glyoxalase I gene polymorphisms in late-onset epilepsy and drug-resistant epilepsy.
Esophageal Squamous Cell Carcinoma
Glyoxalase 1, regulated by LncRNA MALAT1, promotes malignant development of esophageal squamous cell carcinoma.
Fatty Liver
Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Fatty Liver
Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Fibrosarcoma
cDNA cloning and characterization of human glyoxalase I isoforms from HT-1080 cells.
Fibrosarcoma
Proteomic analysis indicates that overexpression and nuclear translocation of lactoylglutathione lyase (GLO1) is associated with tumor progression in murine fibrosarcoma.
Glioma
Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents.
Graves Disease
Association of glyoxalase I allotypes with Graves' disease and diabetes mellitus.
Hemangioma, Cavernous, Central Nervous System
GLYOXALASE I A111E, PARAOXONASE 1 Q192R AND L55M POLYMORPHISMS IN ITALIAN PATIENTS WITH SPORADIC CEREBRAL CAVERNOUS MALFORMATIONS: A PILOT STUDY.
Hemangioma, Cavernous, Central Nervous System
Spectrophotometric Method for Determining Glyoxalase 1 Activity in Cerebral Cavernous Malformation (CCM) Disease.
Hyperglycemia
Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.
Hyperglycemia
Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice.
Hyperglycemia
Effect of antidiabetic compounds on glyoxalase I activity in experimental diabetic rat liver.
Hyperglycemia
Erythrocyte glyoxalase activity in genetically obese (ob/ob) and streptozotocin diabetic mice.
Hyperglycemia
Glycolytic overload-driven dysfunction of periodontal ligament fibroblasts in high glucose concentration, corrected by glyoxalase 1 inducer.
Hyperglycemia
Glyoxalase 1 Prevents Chronic Hyperglycemia Induced Heart-Explant Derived Cell Dysfunction.
Hyperglycemia
Overexpression of glyoxalase-I reduces hyperglycemia-induced levels of advanced glycation end products and oxidative stress in diabetic rats.
Hyperglycemia
Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitro.
Hyperglycemia
Upregulation of glyoxalase I fails to normalize methylglyoxal levels: a possible mechanism for biochemical changes in diabetic mouse lenses.
Hypersensitivity
Absolute Quantification of Allergen Glb33 in Rice by Liquid Chromatography-Mass Spectrometry using Two Isotope-Labeled Standard Peptides.
Hypersensitivity
Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes.
Hypersensitivity
Oryza sativa drought-, heat-, and salt-induced RING finger protein 1 (OsDHSRP1) negatively regulates abiotic stress-responsive gene expression.
Hypertension
Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats.
Hypertension
Reduction of glyoxalase 1 (GLO1) aggravates cerebrovascular remodeling via promoting the proliferation of basilar smooth muscle cells in hypertension.
Infections
Defence against methylglyoxal in Group A Streptococcus: a role for Glyoxylase I in bacterial virulence and survival in neutrophils?
Infections
Identification of a maize kernel stress-related protein and its effect on aflatoxin accumulation
Infections
Identification of a maize kernel stress-related protein and its effect on aflatoxin accumulation.
Insulin Resistance
Dicarbonyl Stress and Glyoxalase-1 in Skeletal Muscle: Implications for Insulin Resistance and Type 2 Diabetes.
Insulin Resistance
GLP-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes.
Insulin Resistance
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
Insulin Resistance
Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial.
Insulin Resistance
Preventive Effect of Eucalyptol on the Formation of Aorta Lesions in the Diabetic-Atherosclerotic Rat.
Insulin Resistance
Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation.
Intestinal Volvulus
A stress-responsive glyoxalase I from the parasitic nematode Onchocerca volvulus.
Kidney Neoplasms
Polymorphisms of the receptor for advanced glycation end-products and glyoxalase I in patients with renal cancer.
lactoylglutathione lyase deficiency
Glyoxalase I deficiency is associated with an unusual level of advanced glycation end products in a hemodialysis patient.
Leishmaniasis
Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I.
Leishmaniasis, Visceral
Glyoxalase I from Leishmania donovani: a potential target for anti-parasite drug.
Leukemia
Further studies on liver glyoxalase I and glyoxalase II. Activity in mice bearing sarcoma 180 and L1210 leukemia.
Leukemia
Glyoxalase I is involved in resistance of human leukemia cells to antitumor agent-induced apoptosis.
Leukemia
Glyoxalase-I is a novel target against Bcr-Abl(+) leukemic cells acquiring stem-like characteristics in a hypoxic environment.
Leukemia
Inhibitory Effect of Isoflavones from Erythrina poeppigiana on the Growth of HL-60 Human Leukemia Cells through Inhibition of Glyoxalase I.
Leukemia
Studies on methylglyoxal. II. Changes of methylglyoxal level accompanying the changes of glyoxalase I and II activities in mice bearing L1210 leukemia and sarcoma 180.
Leukemia, Lymphoid
Synthesis and evaluation of N-alkanoyl-S-benzyl-L-cysteinylglutamic acid esters as glyoxalase I inhibitors and anticancer agents.
Leukemia, Myeloid
Troglitazone overcomes doxorubicin-resistance in resistant K562 leukemia cells.
Liver Cirrhosis
Imbalance in the glutathione system in Opisthorchis felineus infected liver promotes hepatic fibrosis.
Liver Diseases
Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Liver Diseases
Expression of glyoxalase-I is reduced in cirrhotic livers: A possible mechanism in the development of cirrhosis.
Liver Diseases
Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Liver Diseases
The Role of Glyoxalase-I (Glo-I), Advanced Glycation Endproducts (AGEs), and Their Receptor (RAGE) in Chronic Liver Disease and Hepatocellular Carcinoma (HCC).
Lung Neoplasms
Inhibitory Effect of Isoflavones from Erythrina poeppigiana on the Growth of HL-60 Human Leukemia Cells through Inhibition of Glyoxalase I.
Lung Neoplasms
Piceatannol, a natural trans-stilbene compound, inhibits human glyoxalase I.
Lung Neoplasms
TLSC702, a Novel Inhibitor of Human Glyoxalase I, Induces Apoptosis in Tumor Cells.
Lupus Erythematosus, Systemic
HLA-A,B,C, and DR antigens, GLO I and Bf marker profiles in 75 Cape coloured patients with systemic lupus erythematosus (SLE).
Lymphoma, Non-Hodgkin
The purification and characterization of liver glyoxalase I from normal mice and from mice bearing a lymphosarcoma.
Malaria
Glyoxalase-I activity levels in peripheral blood of Ghanaian Africans with or without Plasmodium falciparum.
Malaria
Tight-binding inhibitors efficiently inactivate both reaction centers of monomeric Plasmodium falciparum glyoxalase 1.
Melanoma
Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo.
Metabolic Syndrome
Thiamine reduced metabolic syndrome symptoms in rats via down-regulation of hepatic nuclear factor-k? and induction activity of glyoxalase-I.
Multiple Sclerosis
Advanced Glycation Endproducts Are Increased in the Animal Model of Multiple Sclerosis but Cannot Be Reduced by Pyridoxamine Treatment or Glyoxalase 1 Overexpression.
Neoplasm Metastasis
Genetic Target Modulation Employing CRISPR/Cas9 Identifies Glyoxalase 1 as a Novel Molecular Determinant of Invasion and Metastasis in A375 Human Malignant Melanoma Cells In Vitro and In Vivo.
Neoplasm Metastasis
Glyoxalase 1, regulated by LncRNA MALAT1, promotes malignant development of esophageal squamous cell carcinoma.
Neoplasm Metastasis
Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer.
Neoplasms
2D- and 3D-QSAR modelling, molecular docking and in vitro evaluation studies on 18?-glycyrrhetinic acid derivatives against triple-negative breast cancer cell line.
Neoplasms
A new method for rapidly generating inhibitors of glyoxalase I inside tumor cells using S-(N-aryl-N-hydroxycarbamoyl)ethylsulfoxides.
Neoplasms
Addition of hydrophobic side chains improve the apoptosis inducibility of the human glyoxalase I inhibitor, TLSC702.
Neoplasms
Advances in glyoxalase research. Glyoxalase expression in malignancy, anti-proliferative effects of methylglyoxal, glyoxalase I inhibitor diesters and S-D-lactoylglutathione, and methylglyoxal-modified protein binding and endocytosis by the advanced glycation endproduct receptor.
Neoplasms
Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis.
Neoplasms
Blockage of Glyoxalase I Inhibits Colorectal Tumorigenesis and Tumor Growth via Upregulation of STAT1, p53, and Bax and Downregulation of c-Myc and Bcl-2.
Neoplasms
Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade.
Neoplasms
Carcinostatic activity of methylglyoxal and related substances in tumour-bearing mice.
Neoplasms
Changes in protein expression after neoadjuvant use of aromatase inhibitors in primary breast cancer: a proteomic approach to search for potential biomarkers to predict response or resistance.
Neoplasms
Clinical significance of AGE-RAGE axis in colorectal cancer: associations with glyoxalase-I, adiponectin receptor expression and prognosis.
Neoplasms
Computational and experimental exploration of the structure-activity relationships of flavonoids as potent glyoxalase-I inhibitors.
Neoplasms
Delphinidin, a dietary anthocyanidin in berry fruits, inhibits human glyoxalase I.
Neoplasms
Design, synthesis and biological evaluation of novel glyoxalase I inhibitors possessing diazenylbenzenesulfonamide moiety as potential anticancer agents.
Neoplasms
Differences among human tumor cell lines in the expression of glutathione transferases and other glutathione-linked enzymes.
Neoplasms
Differentiation and apoptosis induction by lovastatin and ?-tocotrienol in HL-60 cells via Ras/ERK/NF-?B and Ras/Akt/NF-?B signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase.
Neoplasms
Discovery of a nanomolar inhibitor of the human glyoxalase-I enzyme using structure-based poly-pharmacophore modelling and molecular docking.
Neoplasms
Effect of piceatannol-rich passion fruit seed extract on human glyoxalase I-mediated cancer cell growth.
Neoplasms
Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2.
Neoplasms
Effects of vitamin D supplementation on advanced glycation end products signaling pathway in T2DM patients: a randomized, placebo-controlled, double blind clinical trial.
Neoplasms
Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures.
Neoplasms
Evaluation of potential flavonoid inhibitors of glyoxalase-I based on virtual screening and in vitro studies.
Neoplasms
Glo1 genetic amplification as a potential therapeutic target in hepatocellular carcinoma.
Neoplasms
Glycerophosphoglycerol, Beta-alanine, and pantothenic Acid as metabolic companions of glycolytic activity and cell migration in breast cancer cell lines.
Neoplasms
Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer.
Neoplasms
Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma.
Neoplasms
Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.
Neoplasms
Glyoxalase 1-419C>A Variant Is Associated with Oxidative Stress: Implications in Prostate Cancer Progression.
Neoplasms
Glyoxalase I (GLO1) is Up-regulated in Pancreatic Cancerous Tissues Compared with Related Non-cancerous Tissues.
Neoplasms
Glyoxalase I activity in human prostate cancer: a potential marker and importance in chemotherapy.
Neoplasms
Glyoxalase I in detoxification: studies using a glyoxalase I transfectant cell line.
Neoplasms
Glyoxalase I in tumor cell proliferation and survival and as a potential target for anticancer therapy.
Neoplasms
Glyoxalase I is differentially expressed in cutaneous neoplasms and contributes to the progression of squamous cell carcinoma.
Neoplasms
Glyoxalase-1-Dependent Methylglyoxal Depletion Sustains PD-L1 Expression in Metastatic Prostate Cancer Cells: A Novel Mechanism in Cancer Immunosurveillance Escape and a Potential Novel Target to Overcome PD-L1 Blockade Resistance.
Neoplasms
Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression.
Neoplasms
High expression of GLO1 indicates unfavorable clinical outcomes in glioma patients.
Neoplasms
Identification of immunodominant regions of Brassica juncea glyoxalase I as potential antitumor immunomodulation targets.
Neoplasms
Identification of the first "two digit nano-molar" inhibitors of the human glyoxalase-I enzyme as potential anticancer agents.
Neoplasms
Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity.
Neoplasms
Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance.
Neoplasms
Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy.
Neoplasms
Inhibition of Glyoxalase-I Leads to Reduced Proliferation, Migration and Colony Formation, and Enhanced Susceptibility to Sorafenib in Hepatocellular Carcinoma.
Neoplasms
Inhibitory Effect of Isoflavones from Erythrina poeppigiana on the Growth of HL-60 Human Leukemia Cells through Inhibition of Glyoxalase I.
Neoplasms
Interdependence of GLO I and PKM2 in the Metabolic shift to escape apoptosis in GLO I-dependent cancer cells.
Neoplasms
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
Neoplasms
Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.
Neoplasms
Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I.
Neoplasms
Phytochemicals against anti-diabetic complications: targeting the advanced glycation end product signaling pathway.
Neoplasms
Polymorphisms of the receptor for advanced glycation end products and glyoxalase I and long-term outcome in patients with breast cancer.
Neoplasms
Preventive Effect of Eucalyptol on the Formation of Aorta Lesions in the Diabetic-Atherosclerotic Rat.
Neoplasms
Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy.
Neoplasms
Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer.
Neoplasms
Proteomic analysis indicates that overexpression and nuclear translocation of lactoylglutathione lyase (GLO1) is associated with tumor progression in murine fibrosarcoma.
Neoplasms
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer.
Neoplasms
Selenium level and glutathione-dependent enzyme activities in normal and neoplastic human lung tissues.
Neoplasms
Structural basis for 18-?-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor.
Neoplasms
Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects.
Neoplasms
Synergistic inhibition of colon cancer growth by the combination of methylglyoxal and silencing of glyoxalase I mediated by the STAT1 pathway.
Neoplasms
The Putative Glyoxalase 1 Inhibitor Piceatannol Exhibits Both Anxiolytic-like and Antitumor Effects in Mice.
Neoplasms
The tumor promoting phorbol diester, 12-O-tetradecanoylphorbol-13-acetate (TPA) increases glyoxalase I and decreases glyoxalase II activity in human polymorphonuclear leukocytes.
Neoplasms
TLSC702, a Novel Inhibitor of Human Glyoxalase I, Induces Apoptosis in Tumor Cells.
Neoplasms
Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes.
Neoplasms
Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE.
Neoplasms
Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I.
Neoplasms
Up-regulation of the tumor promoter Glyoxalase-1 indicates poor prognosis in breast cancer.
Neuritis
HLA antigens in the Landry-Guillain-Barré syndrome and chronic relapsing polyneuritis.
Neuroblastoma
Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
C332C genotype of glyoxalase 1 and its association with late diabetic complications.
Neurodegenerative Diseases
High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons.
Neuroendocrine Tumors
Glyoxalase 1 copy number variation in patients with well differentiated gastro-entero-pancreatic neuroendocrine tumours (GEP-NET).
Non-alcoholic Fatty Liver Disease
Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Obesity
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
Obesity
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
Obesity
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle.
Oligodendroglioma
Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents.
Osteoarthritis
Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis.
Ovarian Neoplasms
Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapy.
Ovarian Neoplasms
Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer.
Overweight
Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation.
Overweight
Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.
Overweight
Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation.
Pancreatic Neoplasms
Soluble receptor for advanced glycation end-products (RAGE) and polymorphisms of RAGE and glyoxalase I genes in patients with pancreas cancer.
Pancreatitis, Chronic
Common variants in glyoxalase I do not increase chronic pancreatitis risk.
Paracoccidioidomycosis
[The association between glyoxalase I and paracoccidioidomycosis infection]
Parasitemia
Glyoxalase-I activity levels in peripheral blood of Ghanaian Africans with or without Plasmodium falciparum.
Parkinson Disease
HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type.
Polycystic Ovary Syndrome
Reduced Ovarian Glyoxalase-I Activity by Dietary Glycotoxins and Androgen Excess: A Causative Link to Polycystic Ovarian Syndrome.
Pre-Eclampsia
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Prostatic Hyperplasia
Glyoxalase activities in tumor and non-tumor human urogenital tissues.
Prostatic Intraepithelial Neoplasia
Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer.
Prostatic Neoplasms
A possible regulatory role of glyoxalase I in cell viability of human prostate cancer.
Prostatic Neoplasms
Chemosensitization of carmustine with maitake beta-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I.
Prostatic Neoplasms
Exploring glyoxalase 1 expression in prostate cancer tissues: Targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties.
Prostatic Neoplasms
Glyoxalase 1 Expression as a Novel Diagnostic Marker of High-Grade Prostatic Intraepithelial Neoplasia in Prostate Cancer.
Prostatic Neoplasms
Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control.
Prostatic Neoplasms
Glyoxalase 1-419C>A Variant Is Associated with Oxidative Stress: Implications in Prostate Cancer Progression.
Prostatic Neoplasms
Glyoxalase I activity in human prostate cancer: a potential marker and importance in chemotherapy.
Prostatic Neoplasms
Glyoxalase I phenotype as a potential risk factor for prostate carcinoma.
Prostatic Neoplasms
High-Level Glyoxalase 1 (GLO1) expression is linked to poor prognosis in prostate cancer.
Prostatic Neoplasms
Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells.
Prostatic Neoplasms, Castration-Resistant
Chemosensitization of carmustine with maitake beta-glucan on androgen-independent prostatic cancer cells: involvement of glyoxalase I.
Proteinuria
Preventive Effect of Eucalyptol on the Formation of Aorta Lesions in the Diabetic-Atherosclerotic Rat.
Renal Insufficiency
Long-term intake of the reactive metabolite methylglyoxal is not toxic in mice.
Renal Insufficiency, Chronic
Glycative Stress and Its Defense Machinery Glyoxalase 1 in Renal Pathogenesis.
Reperfusion Injury
Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats.
Sarcoma
Further studies on liver glyoxalase I and glyoxalase II. Activity in mice bearing sarcoma 180 and L1210 leukemia.
Sarcoma
Studies on methylglyoxal. II. Changes of methylglyoxal level accompanying the changes of glyoxalase I and II activities in mice bearing L1210 leukemia and sarcoma 180.
Sarcoma
Synthesis and cytotoxicity of shikimate analogues. Structure:activity studies based on 1-crotonyloxymethyl-3R,4R,5R-trihydroxycyclohex-2-enone.
Sarcoma 180
Further studies on liver glyoxalase I and glyoxalase II. Activity in mice bearing sarcoma 180 and L1210 leukemia.
Sarcoma 180
Studies on methylglyoxal. II. Changes of methylglyoxal level accompanying the changes of glyoxalase I and II activities in mice bearing L1210 leukemia and sarcoma 180.
Seizures
Genetic and Pharmacological Manipulations of Glyoxalase 1 Mediate Ethanol Withdrawal Seizure Susceptibility in Mice.
Seizures
Glyoxalase 1 and its substrate methylglyoxal are novel regulators of seizure susceptibility.
Seizures
Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats.
Seizures
Role of glyoxalase I gene polymorphisms in late-onset epilepsy and drug-resistant epilepsy.
Sleep Initiation and Maintenance Disorders
Liquid chromatography-mass spectrometry in-depth analysis and in silico verification of the potential active ingredients of Baihe Dihuang decoction in vivo and in vitro.
Spinocerebellar Ataxias
Linkage studies on glyoxalase I (GLO), pepsinogen (PG), spinocerebellar ataxia (SCA1), and HLA.
Squamous Cell Carcinoma of Head and Neck
Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma.
steroid 21-monooxygenase deficiency
Gene frequencies and genetic linkage disequilibrium for the HLA-linked genes Bf, C2, C4S, C4F, 21-hydroxylase deficiency, and glyoxalase I.
Stomach Neoplasms
Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression.
Stomach Neoplasms
Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer.
Subacute Sclerosing Panencephalitis
Partial C4 deficiency in subacute sclerosing panencephalitis.
Tyrosinemias
Representing and reasoning about protein families using generative and discriminative methods.
Urinary Bladder Neoplasms
Discovery of a nanomolar inhibitor of the human glyoxalase-I enzyme using structure-based poly-pharmacophore modelling and molecular docking.
Urolithiasis
Experimental urolithiasis : Part II--a comparative kinetic study of glyoxalase I, glycolate oxidase, alkaline phosphatase & lactate dehydrogenase in the normal rat kidney & bladder & its alterations in urolithiasis.
Vascular Diseases
Genetic predisposition to advanced glycation end products toxicity is related to prognosis of chronic hemodialysis patients.
Vascular Malformations
GLYOXALASE I A111E, PARAOXONASE 1 Q192R AND L55M POLYMORPHISMS IN ITALIAN PATIENTS WITH SPORADIC CEREBRAL CAVERNOUS MALFORMATIONS: A PILOT STUDY.
Ventricular Dysfunction
Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy.
Vitamin B 6 Deficiency
Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex.
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