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Information on EC 4.4.1.36 - hercynylcysteine S-oxide lyase

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EC Tree
IUBMB Comments
Contains pyridoxal 5'-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-(hydroxysulfanyl)hercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
hercynylcysteine sulfoxide lyase, plp-dependent c-s lyase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O
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(1b), spontaneous
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S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-(hydroxysulfanyl)hercynine + pyruvate + NH3
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(1a)
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S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + NH3 + acceptor
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overall reaction
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PATHWAY SOURCE
PATHWAYS
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