Reference on EC 4.4.1.11 - methionine gamma-lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Esaki, N.; Takada, H.; Moriguchi, M.; Hatanaka, S.; Tanaka, H.; Soda, K.
Mechanism-based inactivation of L-methionine gamma-lyase by L-2-amino-4-chloro-4-pentenoate
Biochemistry
28
2111-2116
1989
Pseudomonas putida
-
Takada, H.; Esaki, N.; Tanaka, H.; Soda, K.
The C3-N bond cleavage of 2-amino-3-(N-substituted-amino)-propionic acids catalyzed by L-mehtionine gamma-lyase
Agric. Biol. Chem.
52
2897-2901
1988
Pseudomonas putida
-
Nakayama, T.; Esaki, N.; Tanaka, H.; Soda, K.
Chemical modification of cysteine residues of L-methionine gamma-lyase
Agric. Biol. Chem.
52
177-183
1988
Pseudomonas putida
-
Tanaka, H.; Esaki, N.; Yamamoto, T.; Soda, K.
Purification and properties of methioninase from Pseudomonas ovalis
FEBS Lett.
66
307-311
1976
Pseudomonas putida
Ito, S.; Nakamura, T.; Eguchi, Y.
Purification and characterization of methioninase from Pseudomonas putida
J. Biochem.
79
1263-1272
1976
Pseudomonas putida
Tanaka, H.; Esaki, N.; Soda, K.
Properties of L-methionine gamma-lyase from Pseudomonas ovalis
Biochemistry
16
100-106
1977
Pseudomonas putida
Nakayama, T.; Esaki, N.; Lee, W.J.; Tanaka, I.; Tanaka, H.; Soda, K.
Purification and properties of L-methionine gamma-lyase from Aeromonas sp.
Agric. Biol. Chem.
48
2367-2369
1984
Aeromonas sp.
-
Nakayama, T.; Esaki, N.; Sugie, K.; Beresov, T.T.; Tanaka, H.; Soda, K.
Purification of bacterial L-methionine gamma-lyase
Anal. Biochem.
138
421-424
1984
Pseudomonas putida
Tanaka, H.; Esaki, N.; Soda, K.
A versatile bacterial enzyme: L-methionine gamma-lyase
Enzyme Microb. Technol.
7
530-537
1985
Aeromonas sp., Pseudomonas putida
-
Furuyoshi, S.; Nakayama, T.; Esaki, N.; Takada, H.; Tanaka, H.; Soda, K.
Catalytic action of L-methionine gamma-lyase on 4-azaleucine
Agric. Biol. Chem.
51
3159-3160
1987
Pseudomonas putida
-
Chocat, P.; Esaki, N.; Tanaka, H.; Soda, K.
Synthesis of L-selenodjenkolate and its degradation with methionine gamma-lyase
Anal. Biochem.
148
485-489
1985
Pseudomonas putida
Soda, K.; Tanaka, H.; Esaki, N.
Multifunctional biocatalysis: methionine gamma-lyase
Trends Biochem. Sci.
8
214-217
1983
More, Pseudomonas putida
-
Ito, S.; Nakamura, T.; Eguchi, Y.
Exchange reactions catalyzed by methioninase from Pseudomonas putida
J. Biochem.
78
1105-1107
1975
Pseudomonas putida
Tanaka, H.; Imahara, H.; Esaki, N.; Soda, K.
Determination of L-cysteine with L-methionine gamma-lyase
Agric. Biol. Chem.
45
1021-1022
1981
Pseudomonas putida
-
Esaki, N.; Soda, K.
L-methionine gamma-lyase from Pseudomonas putida and Aeromonas
Methods Enzymol.
143
459-465
1987
Aeromonas sp., Pseudomonas putida
Faleev, N.G.; Troitskaya, M.V.; Paskonova, E.A.; Saporovskaya, M.B.; Belikov, V.M.
L-methionine-gamma-lyase in Citrobacter intermedius cells: Stereochemical requirements with respect to the thiol structure
Enzyme Microb. Technol.
19
590-593
1996
Citrobacter intermedius
-
Lockwood, B.C.; Coombs, G.H.
Purification and characterization of methionine gamma-lyase from Trichomonas vaginalis
Biochem. J.
279
675-682
1991
Trichomonas vaginalis
Tan, Y.; Sun, X.; Xu, M.; An, Z.; Tan, X.; Tan, X.; Han, Q.; Milikovic, D.A.; Yang, M.; Hoffman, R.M.
Polyethylene glycol conjugation of recombinant methioninase for cancer therapy
Protein Expr. Purif.
12
45-52
1998
Pseudomonas putida
McKie, A.E.; Edlind, T.; Walker, J.; Mottram, J.C.; Coombs, G.H.
The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5 -phosphate-dependent enzymes
J. Biol. Chem.
273
5549-5556
1998
Trichomonas vaginalis
Dias, B.; Weimer, B.
Purification and characterization of L-methionine gamma-lyase from Brevibacterium linens BL2
Appl. Environ. Microbiol.
64
3327-3331
1998
Brevibacterium linens
Hori, H.; Takabayashi, K.; Orvis, L.; Carson, D.A.; Nobori, T.
Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
Cancer Res.
56
2116-2122
1996
Pseudomonas putida
Yoshioka, T.; Wada, T.; Uchida, N.; Maki, H.; Yoshida, H.; Ide N.; Kasai, H.; Hojo, K.; Shono, K.; Maekawa, R.; Yagi, S.; Hoffman, R.M.; Sugita, K.
Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase
Cancer Res.
58
2583-2587
1998
Pseudomonas putida
Tan, Y.; Xu, M.; Tan, X.; Wang, X.; Saikawa, Y.; Nagahama, T.; Sun, X.; Lenz, M.; Hoffman, R.M.
Overexpression and large-scale production of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane-lyase for novel anticancer therapy
Protein Expr. Purif.
9
233-245
1997
Pseudomonas putida
Sridhar, V.; Xu, M.; Han, Q.; Sun, X.; Tan, Y.; Hoffman, R.M.; Prasad, G.S.
Crystallization and preliminary crystallographic characterization of recombinant L-methionine-alpha-deamino-gamma-mercaptomethane lyase (methioninase)
Acta Crystallogr. Sect. D
56
1665-1667
2000
Pseudomonas putida
Takakura, T.; Mitsushima, K.; Yagi, S.; Inagaki, K.; Tanaka, H.; Esaki, N.; Soda, K.; Takimoto, A.
Assay method for antitumor L-methionine gamma-lyase: comprehensive kinetic analysis of the complex reaction with L-methionine
Anal. Biochem.
327
233-240
2004
Pseudomonas putida
Yoshimura, M.; Nakano, Y.; Koga, T.
L-Methionine-gamma-lyase, as a target to inhibit malodorous bacterial growth by trifluoromethionine
Biochem. Biophys. Res. Commun.
292
964-968
2002
Porphyromonas gingivalis
Spallholz, J.E.; Palace, V.P.; Reid, T.W.
Methioninase and selenomethionine but not Se-methylselenocysteine generate methylselenol and superoxide in an in vitro chemiluminescent assay: implications for the nutritional carcinostatic activity of selenoamino acids
Biochem. Pharmacol.
67
547-554
2004
Trichomonas vaginalis
Inoue, H.; Inagaki, K.; Adachi, N.; Tamura, T.; Esaki, N.; Soda, K.; Tanaka, H.
Role of tyrosine 114 of L-methionine gamma-lyase from Pseudomonas putida
Biosci. Biotechnol. Biochem.
64
2336-2343
2000
Pseudomonas putida
Abu-Seidah, A.A.; Youssef, M.S.
Characterization of L-methionine g-lyase from Cladosporium cladosporioides
Bull. Fac. Sci. Assiut University, D: Botany
30
83-91
2001
Cladosporium cladosporioides
-
Sun, X.; Yang, Z.; Li, S.; Tan, Y.; Zhang, N.; Wang, X.; Yagi, S.; Yoshioka, T.; Takimoto, A.; Mitsushima, K.; Suginaka, A.; Frenkel, E.P.; Hoffman, R.M.
In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation
Cancer Res.
63
8377-8383
2003
Pseudomonas putida
Motoshima, H.; Inagaki, K.; Kumasaka, T.; Furuichi, M.; Inoue, H.; Tamura, T.; Esaki, N.; Soda, K.; Tanaka, N.; Yamamoto, M.; Tanaka, H.
Crystal structure of the pyridoxal 5'-phosphate dependent L-methionine gamma-lyase from Pseudomonas putida
J. Biochem.
128
349-354
2000
Pseudomonas putida
Tokoro, M.; Asai, T.; Kobayashi, S.; Takeuchi, T.; Nozaki, T.
Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways
J. Biol. Chem.
278
42717-42727
2003
Entamoeba histolytica (Q86D27), Entamoeba histolytica (Q86D28), Entamoeba histolytica
Alferov, K.V.; Faleev, N.G.; Khurs, E.N.; Zhukov, Y.N.; Khomutov, R.M.
A phosphinic analogue of methionine is a substrate of L-methionine-gamma-lyase and induces the synthesis of the enzyme in Citrobacter intermedius cells
Mendeleev Commun.
1
2-3
2002
Citrobacter intermedius
-
Mamaeva, D.V.; Morozova, E.A.; Nikulin, A.D.; Revtovich, S.V.; Nikonov, S.V.; Garber, M.B.; Demidkina, T.V.
Structure of Citrobacter freundii L-methionine gamma-lyase
Acta Crystallogr. Sect. F
61
546-549
2005
Citrobacter freundii
Amarita, F.; Yvon, M.; Nardi, M.; Chambellon, E.; Delettre, J.; Bonnarme, P.
Identification and functional analysis of the gene encoding methionine-gamma-lyase in Brevibacterium linens
Appl. Environ. Microbiol.
70
7348-7354
2004
Brevibacterium linens (Q5MQ31), Brevibacterium linens
Takakura, T.; Ito, T.; Yagi, S.; Notsu, Y.; Itakura, T.; Nakamura, T.; Inagaki, K.; Esaki, N.; Hoffman, R.M.; Takimoto, A.
High-level expression and bulk crystallization of recombinant L-methionine gamma-lyase, an anticancer agent
Appl. Microbiol. Biotechnol.
70
183-192
2006
Pseudomonas putida
Fukamachi, H.; Nakano, Y.; Okano, S.; Shibata, Y.; Abiko, Y.; Yamashita, Y.
High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola
Biochem. Biophys. Res. Commun.
331
127-131
2005
Porphyromonas gingivalis, Treponema denticola
Yang, Z.; Sun, X.; Li, S.; Tan, Y.; Wang, X.; Zhang, N.; Yagi, S.; Takakura, T.; Kobayashi, Y.; Takimoto, A.; Yoshioka, T.; Suginaka, A.; Frenkel, E.P.; Hoffman, R.M.
Circulating half-life of PEGylated recombinant methioninase holoenzyme is highly dose dependent on cofactor pyridoxal-5'-phosphate
Cancer Res.
64
5775-5778
2004
Mus musculus
Takakura, T.; Takimoto, A.; Notsu, Y.; Yoshida, H.; Ito, T.; Nagatome, H.; Ohno, M.; Kobayashi, Y.; Yoshioka, T.; Inagaki, K.; Yagi, S.; Hoffman, R.M.; Esaki, N.
Physicochemical and pharmacokinetic characterization of highly potent recombinant L-methionine gamma-lyase conjugated with polyethylene glycol as an antitumor agent
Cancer Res.
66
2807-2814
2006
Mus musculus
Manukhov, I.V.; Mamaeva, D.V.; Rastorguev, S.M.; Faleev, N.G.; Morozova, E.A.; Demidkina, T.V.; Zavilgelsky, G.B.
A gene encoding L-methionine gamma-lyase is present in Enterobacteriaceae family genomes: identification and characterization of Citrobacter freundii L-methionine gamma-lyase
J. Bacteriol.
187
3889-3893
2005
Citrobacter freundii (Q84AR1), Citrobacter freundii, Citrobacter freundii ATCC 29063 (Q84AR1)
Nikulin, A.; Revtovich, S.; Morozova, E.; Nevskaya, N.; Nikonov, S.; Garber, M.; Demidkina, T.
High-resolution structure of methionine gamma-lyase from Citrobacter freundii
Acta Crystallogr. Sect. D
64
211-218
2008
Citrobacter freundii
Sato, D.; Yamagata, W.; Kamei, K.; Nozaki, T.; Harada, S.
Expression, purification and crystallization of L-methionine gamma -lyase 2 from Entamoeba histolytica
Acta Crystallogr. Sect. F
F62
1034-1036
2006
Entamoeba histolytica (Q86D27), Entamoeba histolytica
Martinez-Cuesta, M.C.; Pelaez, C.; Eagles, J.; Gasson, M.J.; Requena, T.; Hanniffy, S.B.
YtjE from Lactococcus lactis IL1403 Is a C-S lyase with alpha, gamma-elimination activity toward methionine
Appl. Environ. Microbiol.
72
4878-4884
2006
Lactococcus lactis, Lactococcus lactis IL1403
Manukhov, I.V.; Mamaeva, D.V.; Morozova, E.A.; Rastorguev, S.M.; Faleev, N.G.; Demidkina, T.V.; Zavilgelsky, G.B.
L-methionine gamma-lyase from Citrobacter freundii: cloning of the gene and kinetic parameters of the enzyme
Biochemistry (Moscow)
71
361-369
2006
Citrobacter freundii
Sato, D.; Yamagata, W.; Harada, S.; Nozaki, T.
Kinetic characterization of methionine gamma-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis
FEBS J.
275
548-560
2008
Entamoeba histolytica (Q86D27), Entamoeba histolytica (Q86D28), Entamoeba histolytica
Vermeij, P.; Kertesz, M.A.
Pathways of assimilative sulfur metabolism in Pseudomonas putida
J. Bacteriol.
181
5833-5837
1999
Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida S-313
Kudou, D.; Misaki, S.; Yamashita, M.; Tamura, T.; Takakura, T.; Yoshioka, T.; Yagi, S.; Hoffman, R.M.; Takimoto, A.; Esaki, N.; Inagaki, K.
Structure of the antitumour enzyme L-methionine gamma-lyase from Pseudomonas putida at 1.8 A resolution
J. Biochem.
141
535-544
2007
Pseudomonas putida (P13254), Pseudomonas putida
Kim, A.; Oh, J.H.; Park, J.M.; Chung, A.S.
Methylselenol generated from selenomethionine by methioninase downregulates integrin expression and induces caspase-mediated apoptosis of B16F10 melanoma cells
J. Cell. Physiol.
212
386-400
2007
Mus musculus
Zhao, R.; Domann, F.E.; Zhong, W.
Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells
Mol. Cancer Ther.
5
3275-3284
2006
Homo sapiens
Goyer, A.; Collakova, E.; Shachar-Hill, Y.; Hanson, A.D.
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway
Plant Cell Physiol.
48
232-242
2007
Arabidopsis thaliana
Rebeille, F.; Jabrin, S.; Bligny, R.; Loizeau, K.; Gambonnet, B.; Van Wilder, V.; Douce, R.; Ravanel, S.
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses
Proc. Natl. Acad. Sci. USA
103
15687-15692
2006
Arabidopsis thaliana
Sato, D.; Karaki, T.; Shimizu, A.; Kamei, K.; Harada, S.; Nozaki, T.
Crystallization and preliminary X-ray analysis of L-methionine gamma-lyase 1 from Entamoeba histolytica
Acta Crystallogr. Sect. F
64
697-699
2008
Entamoeba histolytica (Q86D28), Entamoeba histolytica
Kudou, D.; Misaki, S.; Yamashita, M.; Tamura, T.; Esaki, N.; Inagaki, K.
The role of cysteine 116 in the active site of the antitumor enzyme L-methionine gamma-lyase from Pseudomonas putida
Biosci. Biotechnol. Biochem.
72
1722-1730
2008
Pseudomonas putida (P13254), Pseudomonas putida
Ito, S.; Narise, A.; Shimura, S.
Identification of a methioninase inhibitor, myrsinoic acid B, from Myrsine seguinii Lev., and its inhibitory activities
Biosci. Biotechnol. Biochem.
72
2411-2414
2008
Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola, Fusobacterium nucleatum JCM 8532, Porphyromonas gingivalis W83, Treponema denticola ATCC 35405
Khalaf, S.A.; El-Sayed, A.S.
L-methioninase production by filamentous fungi: I-screening and optimization under submerged conditions
Curr. Microbiol.
58
219-226
2009
Aspergillus carneus, Aspergillus flavipes, Aspergillus flavus, Aspergillus niger, Aspergillus ochraceus, Aspergillus oryzae, Aspergillus parasiticus, Aspergillus tamarii, Fusarium oxysporum, Microdochium nivale, Fusarium solani, Mucor racemosus, Penicillium chrysogenum, Penicillium citrinum, Scopulariopsis brevicaulis, Trichoderma koningii, Penicillium digitatum, Cladosporium oxysporum, Humicola fuscoatra, Penicillium egyptiacum, Aspergillus subolivaceus
Hu, J.; Cheung, N.K.
Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs
Int. J. Cancer
124
1700-1706
2009
Pseudomonas putida
Han, Q.; Hoffman, R.M.
Enzymatic assay for total plasma Cys
Nat. Protoc.
3
1778-1781
2008
Pseudomonas putida
Joshi, V.; Joung, J.G.; Fei, Z.; Jander, G.
Interdependence of threonine, methionine and isoleucine metabolism in plants: accumulation and transcriptional regulation under abiotic stress
Amino Acids
39
933-947
2010
Arabidopsis thaliana
Hanniffy, S.B.; Philo, M.; Pelaez, C.; Gasson, M.J.; Requena, T.; Martinez-Cuesta, M.C.
Heterologous production of methionine-gamma-lyase from Brevibacterium linens in Lactococcus lactis and formation of volatile sulfur compounds
Appl. Environ. Microbiol.
75
2326-2332
2009
Brevibacterium linens BL2 (Q5MQ31), Brevibacterium linens BL2
El-Sayed, A.S.
Microbial L-methioninase: production, molecular characterization, and therapeutic applications
Appl. Microbiol. Biotechnol.
86
445-467
2010
Achromobacter starkeyi, Aeromonas sp., Aspergillus flavipes, Aspergillus sp., Citrobacter freundii, Citrobacter intermedius, Cladosporium cladosporioides, Clostridium sporogenes, Entamoeba histolytica, Lactococcus lactis, no activity in mammalia, Pseudomonas putida, Treponema denticola, Trichomonas vaginalis, Brevibacterium linens BL2, Aspergillus sp. Rs-1a
Faleev, N.G.; Alferov, K.V.; Tsvetikova, M.A.; Morozova, E.A.; Revtovich, S.V.; Khurs, E.N.; Vorobev, M.M.; Phillips, R.S.; Demidkina, T.V.; Khomutov, R.M.
Methionine gamma-lyase: mechanistic deductions from the kinetic pH-effects. The role of the ionic state of a substrate in the enzymatic activity
Biochim. Biophys. Acta
1794
1414-1420
2009
Citrobacter freundii
Sato, D.; Kobayashi, S.; Yasui, H.; Shibata, N.; Toru, T.; Yamamoto, M.; Tokoro, G.; Ali, V.; Soga, T.; Takeuchi, T.; Suematsu, M.; Nozaki, T.
Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica
Int. J. Antimicrob. Agents
35
56-61
2010
Entamoeba histolytica
Sato, D.; Nozaki, T.
Methionine gamma-lyase: the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers
IUBMB Life
61
1019-1028
2009
Arabidopsis thaliana, Porphyromonas gingivalis, Brevibacterium linens, Entamoeba histolytica, Fusobacterium nucleatum, Prevotella denticola, Pseudomonas putida, Trichomonas vaginalis (O15564), Trichomonas vaginalis (O15565)
El-Sayed, A.S.
L-methioninase production by Aspergillus flavipes under solid-state fermentation
J. Basic Microbiol.
49
331-341
2009
Aspergillus flavipes
Palwai, N.R.; Zang, X.P.; Harrison, R.G.; Benbrook, D.; Pento, J.T.
Selective growth inhibition of cancer cells by L-methioninase-containing fusion protein targeted to the urokinase receptor
Pharmacology
84
271-275
2009
Escherichia coli BL21
Joshi, V.; Jander, G.
Arabidopsis methionine gamma-lyase is regulated according to isoleucine biosynthesis needs but plays a subordinate role to threonine deaminase
Plant Physiol.
151
367-378
2009
Arabidopsis thaliana (Q9SGU9)
Morozova, E.A.; Bazhulina, N.P.; Anufrieva, N.V.; Mamaeva, D.V.; Tkachev, Y.V.; Streltsov, S.A.; Timofeev, V.P.; Faleev, N.G.; Demidkina, T.V.
Kinetic and spectral parameters of interaction of Citrobacter freundii methionine gamma-lyase with amino acids
Biochemistry (Moscow)
75
1272-1280
2010
Citrobacter freundii
Ronda, L.; Bazhulina, N.P.; Morozova, E.A.; Revtovich, S.V.; Chekhov, V.O.; Nikulin, A.D.; Demidkina, T.V.; Mozzarelli, A.
Exploring methionine gamma-lyase structure-function relationship via microspectrophotometry and X-ray crystallography
Biochim. Biophys. Acta
1814
834-842
2011
Citrobacter freundii
Suwabe, K.; Yoshida, Y.; Nagano, K.; Yoshimura, F.
Identification of an L-methionine gamma-lyase involved in the production of hydrogen sulfide from L-cysteine in Fusobacterium nucleatum subsp. nucleatum ATCC 25586
Microbiology
157
2992-3000
2011
Treponema denticola (Q73KL7), Porphyromonas gingivalis (Q7MX71), Fusobacterium nucleatum subsp. nucleatum (Q8RDT4), Porphyromonas gingivalis W83 (Q7MX71), Treponema denticola ATCC 35405 (Q73KL7), Fusobacterium nucleatum subsp. nucleatum ATCC 25586 / JCM14847 (Q8RDT4)
Morozova, E.A.; Kulikova, V.V.; Yashin, D.V.; Anufrieva, N.V.; Anisimova, N.Y.; Revtovich, S.V.; Kotlov, M.I.; Belyi, Y.F.; Pokrovsky, V.S.; Demidkina, T.V.
Kinetic parameters and cytotoxic activity of recombinant methionine gamma-lyase from Clostridium tetani, Clostridium sporogenes, Porphyromonas gingivalis and Citrobacter freundii
Acta Naturae
5
92-98
2013
Porphyromonas gingivalis, Citrobacter freundii, Clostridium sporogenes, Clostridium tetani
Saa, L.; Mato, J.M.; Pavlov, V.
Assays for methionine beta-lyase and S-adenosyl-L-homocysteine hydrolase based on enzymatic formation of CdS quantum dots in situ
Anal. Chem.
84
8961-8965
2012
Pseudomonas putida, Pseudomonas putida ICR 3460
Revtovich, S.V.; Morozova, E.A.; Khurs, E.N.; Zakomirdina, L.N.; Nikulin, A.D.; Demidkina, T.V.; Khomutov, R.M.
Three-dimensional structures of noncovalent complexes of Citrobacter freundii methionine gamma-lyase with substrates
Biochemistry (Moscow)
76
564-570
2011
Citrobacter freundii (Q84AR1)
Revtovich, S.V.; Faleev, N.G.; Morozova, E.A.; Anufrieva, N.V.; Nikulin, A.D.; Demidkina, T.V.
Crystal structure of the external aldimine of Citrobacter freundii methionine gamma-lyase with glycine provides insight in mechanisms of two stages of physiological reaction and isotope exchange of alpha- and beta-protons of competitive inhibitors
Biochimie
101
161-167
2014
Citrobacter freundii (Q84AR1)
Fukumoto, M.; Kudou, D.; Murano, S.; Shiba, T.; Sato, D.; Tamura, T.; Harada, S.; Inagaki, K.
The role of amino acid residues in the active site of L-methionine gamma-lyase from Pseudomonas putida
Biosci. Biotechnol. Biochem.
76
1275-1284
2012
Pseudomonas putida (P13254)
Huang, T.; Joshi, V.; Jander, G.
The catabolic enzyme methionine gamma-lyase limits methionine accumulation in potato tubers
Plant Biotechnol. J.
12
883-893
2014
Solanum tuberosum
Khan, M.A.; Lopez-Munoz, M.M.; Kaspar, C.W.; Hung, K.F.
Activities of methionine-gamma-lyase in the acidophilic archaeon Ferroplasma acidarmanus strain fer1
Res. Rep. Biol.
4
11-22
2013
Ferroplasma acidarmanus, Ferroplasma acidarmanus Fer1
-
Revtovich, S.; Anufrieva, N.; Morozova, E.; Kulikova, V.; Nikulin, A.; Demidkina, T.
Structure of methionine gamma-lyase from Clostridium sporogenes
Acta Crystallogr. Sect. F
72
65-71
2016
Clostridium sporogenes (J7TA22), Clostridium sporogenes, Clostridium sporogenes ATCC 15579 (J7TA22)
Foo, T.C.; Terentis, A.C.; Venkatachalam, K.V.
A continuous spectrophotometric assay and nonlinear kinetic analysis of methionine gamma-lyase catalysis
Anal. Biochem.
507
21-26
2016
Porphyromonas gingivalis (C3VMV9), Porphyromonas gingivalis
Anufrieva, N.V.; Faleev, N.G.; Morozova, E.A.; Bazhulina, N.P.; Revtovich, S.V.; Timofeev, V.P.; Tkachev, Y.V.; Nikulin, A.D.; Demidkina, T.V.
The role of active site tyrosine 58 in Citrobacter freundii methionine gamma-lyase
Biochim. Biophys. Acta
1854
1220-1228
2015
Citrobacter freundii (Q84AR1), Citrobacter freundii
Revtovich, S.V.; Morozova, E.A.; Kulikova, V.V.; Anufrieva, N.V.; Osipova, T.I.; Koval, V.S.; Nikulin, A.D.; Demidkina, T.V.
Crystal structure of mutant form Cys115His of Citrobacter freundii methionine gamma-lyase complexed with l-norleucine
Biochim. Biophys. Acta
1865
1123-1128
2017
Citrobacter freundii (Q84AR1)
Raboni, S.; Revtovich, S.; Demitri, N.; Giabbai, B.; Storici, P.; Cocconcelli, C.; Faggiano, S.; Rosini, E.; Pollegioni, L.; Galati, S.; Buschini, A.; Morozova, E.; Kulikova, V.; Nikulin, A.; Gabellieri, E.; Cioni, P.; Demidkina, T.; Mozzarelli, A.
Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity
Biochim. Biophys. Acta
1866
1260-1270
2018
Citrobacter freundii (Q84AR1), Citrobacter freundii
Morozova, E.; Kulikova, V.; Rodionov, A.; Revtovich, S.; Anufrieva, N.; Demidkina, T.
Engineered Citrobacter freundii methionine gamma-lyase effectively produces antimicrobial thiosulfinates
Biochimie
128-129
92-98
2016
Citrobacter freundii (Q84AR1), Citrobacter freundii
Kulikova, V.; Morozova, E.; Rodionov, A.; Koval, V.; Anufrieva, N.; Revtovich, S.; Demidkina, T.
Non-stereoselective decomposition of (+-)-S-alk(en)yl-l-cysteine sulfoxides to antibacterial thiosulfinates catalyzed by C115H mutant methionine gamma-lyase from Citrobacter freundii
Biochimie
151
42-44
2018
Citrobacter freundii (Q84AR1), Citrobacter freundii
Morozova, E.A.; Anufrieva, N.V.; Davydov, D.Z.; Komarova, M.V.; Dyakov, I.N.; Rodionov, A.N.; Demidkina, T.V.; Pokrovsky, V.S.
Plasma methionine depletion and pharmacokinetic properties in mice of methionine gamma-lyase from Citrobacter freundii, Clostridium tetani and Clostridium sporogenes
Biomed. Pharmacother.
88
978-984
2017
Clostridium tetani (A0A1L7H888), Clostridium tetani, Clostridium sporogenes (J7TA22), Clostridium sporogenes, Citrobacter freundii (Q84AR1), Citrobacter freundii, Clostridium sporogenes ATCC 15579 (J7TA22)
Song, H.; Xu, R.; Guo, Z.
Identification and characterization of a methionine gamma-lyase in the calicheamicin biosynthetic cluster of Micromonospora echinospora
ChemBioChem
16
100-109
2015
Micromonospora echinospora (Q8KNG3), Micromonospora echinospora
Kumar, P.; Jander, G.
Concurrent overexpression of Arabidopsis thaliana cystathionine gamma-synthase and silencing of endogenous methionine gamma-lyase enhance tuber methionine content in Solanum tuberosum
J. Agric. Food Chem.
65
2737-2742
2017
Solanum tuberosum
Kuznetsov, N.A.; Faleev, N.G.; Kuznetsova, A.A.; Morozova, E.A.; Revtovich, S.V.; Anufrieva, N.V.; Nikulin, A.D.; Fedorova, O.S.; Demidkina, T.V.
Pre-steady-state kinetic and structural analysis of interaction of methionine gamma-lyase from Citrobacter freundii with inhibitors
J. Biol. Chem.
290
671-681
2015
Citrobacter freundii (Q84AR1), Citrobacter freundii
Kudou, D.; Yasuda, E.; Hirai, Y.; Tamura, T.; Inagaki, K.
Molecular cloning and characterization of L-methionine gamma-lyase from Streptomyces avermitilis
J. Biosci. Bioeng.
120
380-383
2015
Streptomyces avermitilis (Q826W3), Streptomyces avermitilis, Streptomyces avermitilis DSM 46492 (Q826W3)
Morozova, E.A.; Kulikova, V.V.; Faggiano, S.; Raboni, S.; Gabellieri, E.; Cioni, P.; Anufrieva, N.V.; Revtovich, S.V.; Demidkina, T.; Mozzarelli, A.
Soluble and nanoporous silica gel-entrapped C. freundii methionine gamma-lyase
J. Nanosci. Nanotechnol.
18
2210-2219
2018
Citrobacter freundii (Q84AR1)
Huang, K.Y.; Hu, H.Y.; Tang, Y.L.; Xia, F.G.; Luo, X.Q.; Liu, J.Z.
High-level expression, purification and large-scale production of L-methionine gamma-lyase from Idiomarina as a novel anti-leukemic drug
Mar. Drugs
13
5492-5507
2015
Idiomarina sp.
Stephen, A.; Millhouse, E.; Sherry, L.; Aduse-Opoku, J.; Culshaw, S.; Ramage, G.; Bradshaw, D.; Burnett, G.; Allaker, R.
In vitro effect of Porphyromonas gingivalis methionine gamma lyase on biofilm composition and oral inflammatory response
PLoS ONE
11
e0169157
2016
Porphyromonas gingivalis
Sato, D.; Shiba, T.; Yunoto, S.; Furutani, K.; Fukumoto, M.; Kudou, D.; Tamura, T.; Inagaki, K.; Harada, S.
Structural and mechanistic insights into homocysteine degradation by a mutant of methionine gamma-lyase based on substrate-assisted catalysis
Protein Sci.
26
1224-1230
2017
Pseudomonas putida (P13254), Pseudomonas putida
Cao, H.; Tan, K.; Wang, F.; Bigelow, L.; Yennamalli, R.; Jedrzejczak, R.; Babnigg, G.; Bingman, C.; Joachimiak, A.; Kharel, M.; Singh, S.; Thorson, J.; Phillips, G.J.
Structural dynamics of a methionine gamma-lyase for calicheamicin biosynthesis Rotation of the conserved tyrosine stacking with pyridoxal phosphate
Struct. Dyn.
3
034702
2016
Micromonospora echinospora (Q8KNG3), Micromonospora echinospora
Lin, B.; Tian, G.; Liu, Y.
Mechanistic insights into the gamma-elimination reaction of L-methionine catalyzed by methionine gamma-lyase (MGL)
Theoret. Chem. Accounts
136
105
2017
Clostridium sporogenes (J7TA22), Citrobacter freundii (Q84AR1), Clostridium sporogenes ATCC 15579 (J7TA22)
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