Information on EC 4.4.1.10 - cysteine lyase

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The expected taxonomic range for this enzyme is: Gnathostomata

EC NUMBER
COMMENTARY
4.4.1.10
-
RECOMMENDED NAME
GeneOntology No.
cysteine lyase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
L-cysteine + sulfite = L-cysteate + hydrogen sulfide
show the reaction diagram
-
-
-
-
L-cysteine + sulfite = L-cysteate + hydrogen sulfide
show the reaction diagram
beta-replacement reaction
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
elimination
-
-
of H2S or RSH, C-S bond cleavage
-
PATHWAY
KEGG Link
MetaCyc Link
Cysteine and methionine metabolism
-
Metabolic pathways
-
Taurine and hypotaurine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
L-cysteine hydrogen-sulfide-lyase (adding sulfite; L-cysteate-forming)
A pyridoxal-phosphate protein. Can use a second molecule of cysteine (producing lanthionine), or other alkyl thiols, as a replacing agent.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
lyase, cysteine (sulfite)
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9079-86-1
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
bat
-
-
-
Manually annotated by BRENDA team
batrachian
-
-
-
Manually annotated by BRENDA team
Callopanchax sp.
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Epiplatys sp.
-
-
-
Manually annotated by BRENDA team
Turtle
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-Cys + 2-mercaptoethanol
S-(2-hydroxyethyl)cysteine + ?
show the reaction diagram
-
-
-
-
?
L-Cys + 2-mercaptoethanol
S-(2-hydroxyethyl)cysteine + ?
show the reaction diagram
-
-
-
?
L-Cys + 3-mercaptopropionate
?
show the reaction diagram
-
-
-
-
?
L-Cys + 3-mercaptopropionate
?
show the reaction diagram
-
weak
-
-
?
L-Cys + cysteamine
S-(2-amino-2-carboxyethyl)cysteine + ?
show the reaction diagram
-
-
-
?
L-Cys + dithiothreitol
?
show the reaction diagram
-
-
-
-
?
L-Cys + ethanethiol
?
show the reaction diagram
-
-
-
-
?
L-Cys + L-Cys
lanthionine
show the reaction diagram
-
-
-
?
L-Cys + methanethiol
?
show the reaction diagram
-
-
-
-
?
L-Cys + sulfite
L-cysteate + H2S
show the reaction diagram
-
-
-
?
L-Cys + sulfite
L-cysteate + H2S
show the reaction diagram
-
-
-
?
L-Cys + sulfite
L-cysteate + H2S
show the reaction diagram
-
-
-
?
L-Cys + sulfite
?
show the reaction diagram
-
production of L-cysteate, the precursor of the fetal metabolite taurine
-
-
-
L-Cys + thioglycolate
?
show the reaction diagram
-
-
-
-
?
L-Cys + thioglycolate
?
show the reaction diagram
-
weak
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-Cys + sulfite
?
show the reaction diagram
-
production of L-cysteate, the precursor of the fetal metabolite taurine
-
-
-
COFACTOR
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
dependent
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
additional information
-
no inhibition by: 20 mM L-Cys, 20 mM penicillamine, 20 mM cysteamine, 20 mM cycloserine
-
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
7.7
-
2-mercaptoethanol
-
-
8.3
-
L-Cys
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
8.7
8.8
-
-
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
batrachian
-
of the ventral endoderm, tail-bud stage
Manually annotated by BRENDA team
Callopanchax sp., Elasmobranchii, Epiplatys sp., Rivulus sp.
-
-
Manually annotated by BRENDA team
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
120000
-
-
-
SUBUNITS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dimer
-
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE