Information on EC 4.3.3.3 - deacetylisoipecoside synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.3.3.3
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RECOMMENDED NAME
GeneOntology No.
deacetylisoipecoside synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
deacetylisoipecoside + H2O = dopamine + secologanin
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C-C bond formation
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-
-
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C-N bond formation
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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emetine biosynthesis
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Isoquinoline alkaloid biosynthesis
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Metabolic pathways
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SYSTEMATIC NAME
IUBMB Comments
deacetylisoipecoside dopamine-lyase (secologanin-forming)
The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 4.3.3.4 deacetylipecoside synthase. The product is rapidly converted to demethylisoalangiside.
CAS REGISTRY NUMBER
COMMENTARY hide
192827-94-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Alangium lamarckii
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-
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
dopamine + secologanin
(1S)-deacetylisoipecoside + H2O
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
dopamine + secologanin
(1S)-deacetylisoipecoside + H2O
show the reaction diagram
Alangium lamarckii
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involved in production of tetrahydroquinoline monoterpene alkaloide derivates
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?
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
Alangium lamarckii
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-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Alangium lamarckii
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-
Manually annotated by BRENDA team
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
Alangium lamarckii
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