Reference on EC 4.3.3.2 - strictosidine synthase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stevens, L.H.; Blom, T.J.M.; Verpoorte, R.
Subcellular localization of tryptophan decarboxylase, strictosidine synthase and strictosidine glucosidase in suspension cultured cells of Catharanthus roseus and Tabernaemontana divaricata
Plant Cell Rep.
12
573-576
1993
Catharanthus roseus, Tabernaemontana divaricata
Kutchan, T.M.; Bock, A.; Dittrich, H.
Heterologous expression of the plant proteins strictosidine synthase and berberine bridge enzyme in insect cell culture
Phytochemistry
35
353-360
1994
BRENDA: Rauvolfia serpentina
Textmining: plant, Eschscholzia californica, Spodoptera frugiperda
Treimer, J.F.; Zenk, M.H.
Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation
Eur. J. Biochem.
101
225-233
1979
Amsonia salicifolia, Amsonia tabernaemontana, Catharanthus longifolius, Catharanthus pusillus, Catharanthus roseus, Catharanthus trichophyllus, Ervatamia divaricatum, Ochrosia elliptica, Rauvolfia verticillata, Rauvolfia vomitoria, Amsonia orientalis, Stemmadenia tomentosa var. palmeri, Vinca major, Vinca minor, Voacanga africana
Mizukami, H.; Nordlov, H.; Lee, S.L.; Scott, A.I.
Purification and properties of strictosidine synthetase (an enzyme condensing tryptamine and secologanin) from Catharanthus roseus cultured cell
Biochemistry
18
3760-3763
1979
Catharanthus roseus
Treimer, J.F.; Zenk, M.H.
Strictosidine synthase from cell cultrues of Apocynaceae plants
FEBS Lett.
97
159-162
1979
Amsonia salicifolia, Catharanthus roseus, Ochrosia elliptica, Rauvolfia vomitoria, Amsonia orientalis, Stemmadenia tomentosa var. palmeri, Vinca major, Vinca minor, Voacanga africana
-
Pfitzner, U.; Zenk, M.H.
Immobilization of strictosidine synthase from Catharanthus cell cultures and preparative synthesis of strictosidine
Planta Med.
46
10-14
1982
BRENDA: Catharanthus roseus
Textmining: Catharanthus
Skinner, S.E.; Walton, N.J.; Robins, R.J.; Rhodes, M.J.C.
Tryptophan decarboxylase, strictosidine synthase and alkaloid production by Cinchona ledgerinana suspension cultures
Phytochemistry
26
721-725
1987
Cinchona calisaya
-
Pfitzner, U.; Zenk, M.H.
Isoation and immobilization of strictosidine synthase
Methods Enzymol.
136
342-350
1987
Catharanthus roseus
-
Hampp, N.; Zenk, M.H.
Homogeneous strictosidine synthase from cell suspension cultures of Rauvolfia serpentina
Phytochemistry
27
3811-3815
1988
Rauvolfia serpentina
-
Pennings, E.J.M.; Van den Bosch, R.A.; Van der Heijden, R.; Stevens, L.H.; Duine, J.A.; Verpoorte, R.
Assay of trictosidine synthase from plant cell cultures by high-performance liquid chromatography
Anal. Biochem.
176
412-415
1989
BRENDA: Catharanthus roseus, Tabernaemontana orientalis
Textmining: plant
Roessner, C.A.; Devagupta, R.; Hasan, M.; Williams, H.J.; Scott, A.I.
Purification of an indole alkaloid biosynthetic enzyme, strictosidine synthase, from a recombinant strain of Escherichia coli
Protein Expr. Purif.
3
295-300
1992
BRENDA: Catharanthus roseus
Textmining: Escherichia coli
Bracher, D.; Kutchan, T.M.
Strictosidine synthase from Rauvolfia serpentina: analysis of a gene involved in indole alkaloid biosynthesis
Arch. Biochem. Biophys.
294
717-723
1992
BRENDA: Rauvolfia mannii, Rauvolfia serpentina
Textmining: plant, Nicotiana plumbaginifolia, Cauliflower mosaic virus, Areas
Stevens, L.H.; Giroud, C.; Pennings, E.J.M.; Verpoorte, R.
Purification and characterization of strictosidine synthase from a suspension culture of Cinchona robusta
Phytochemistry
33
99-106
1993
Catharanthus roseus, Cinchona robusta
-
de Waal, A.; Meijer, A.H.; Verpoorte, R.
Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms
Biochem. J.
306
571-580
1995
BRENDA: Catharanthus roseus
Textmining: plant
Hallard, D.; Van der Heijden, R.; Verpoorte, R.; Lopes Cardoso, M.I.; Pasquali, G.; Memelink, J.; Hoge, J.H.C.
Suspension cultured transgenic cells of Nicotiana tabacum expressing tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus produce strictosidine upon secologanin feeding.
Plant Cell Rep.
17
50-54
1997
Catharanthus roseus
Canel, C.; Lopes-Cardoso, M.I.; Whitmer, S.; van der Fits, L.; Pasquali, G.; van der Heijden, R.; Hoge, J.H.; Verpoorte, R.
Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus
Planta
205
414-419
1998
BRENDA: Catharanthus roseus (P18417), Catharanthus roseus
Textmining: Transformation
Pasquali, G.; Erven, A.S.; Ouwerkerk, P.B.; Menke, F.L.; Memelink, J.
The promoter of the strictosidine synthase gene from periwinkle confers elicitor-inducible expression in transgenic tobacco and binds nuclear factors GT-1 and GBF
Plant Mol. Biol.
39
1299-1310
1999
BRENDA: Catharanthus roseus
Textmining: Nicotiana tabacum, plant
Whitmer, S.; van der Heijden, R.; Verpoorte, R.
Effect of precursor feeding on alkaloid accumulation by a strictosidine synthase over-expressing transgenic cell line S1 of Catharanthus roseus
Plant Cell Tissue Organ Cult.
69
85-93
2002
Catharanthus roseus
-
Yamazaki, Y.; Urano, A.; Sudo, H.; Kitajima, M.; Takayama, H.; Yamazaki, M.; Aimi, N.; Saito, K.
Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants
Phytochemistry
62
461-470
2003
BRENDA: Ophiorrhiza pumila
Textmining: Camptotheca acuminata, Nothapodytes nimmoniana
Dutta, A.; Batra, J.; Pandey-Rai, S.; Singh, D.; Kumar, S.; Sen, J.
Expression of terpenoid indole alkaloid biosynthetic pathway genes corresponds to accumulation of related alkaloids in Catharanthus roseus (L.) G. Don
Planta
220
376-383
2005
Catharanthus roseus (O04847), Catharanthus roseus, Catharanthus roseus (Q9ZTK5), plant
Koepke, J.; Ma, X.; Fritzsch, G.; Michel, H.; Stockigt, J.
Crystallization and preliminary X-ray analysis of strictosidine synthase and its complex with the substrate tryptamine
Acta Crystallogr. Sect. D
61
690-693
2005
BRENDA: Rauvolfia serpentina
Textmining: plant, Escherichia coli
Ma, X.; Koepke, J.; Fritzsch, G.; Diem, R.; Kutchan, T.M.; Michel, H.; Stockigt, J.
Crystallization and preliminary X-ray crystallographic analysis of strictosidine synthase from Rauvolfia: the first member of a novel enzyme family
Biochim. Biophys. Acta
1702
121-124
2004
BRENDA: Rauvolfia serpentina
Textmining: Rauvolfia, Escherichia coli, plant
McCoy, E.; Galan, M.C.; O'Connor S.E.
Substrate specificity of strictosidine synthase
Bioorg. Med. Chem. Lett.
16
2475-2478
2006
Escherichia coli
Ma, X.; Panjikar, S.; Koepke, J.; Loris, E.; Stockigt, J.
The Structure of Rauvolfia serpentina Strictosidine Synthase Is a Novel Six-Bladed {beta}-Propeller Fold in Plant Proteins
Plant Cell
18
907-920
2006
BRENDA: Rauvolfia serpentina (P68175), Rauvolfia serpentina
Textmining: plant, Embryophyta
Chen, S.; Galan, M.C.; Coltharp, C.; OConnor, S.E.
Redesign of a central enzyme in alkaloid biosynthesis
Chem. Biol.
13
1137-1141
2006
BRENDA: Catharanthus roseus
Textmining: plant
Bernhardt, P.; McCoy, E.; OConnor, S.E.
Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle
Chem. Biol.
14
888-897
2007
Catharanthus roseus
Loris, E.A.; Panjikar, S.; Ruppert, M.; Barleben, L.; Unger, M.; Schuebel, H.; Stoeckigt, J.
Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries
Chem. Biol.
14
979-985
2007
BRENDA: Rauvolfia serpentina
Textmining: Embryophyta, Catharanthus
Maresh, J.J.; Giddings, L.A.; Friedrich, A.; Loris, E.A.; Panjikar, S.; Trout, B.L.; Stoeckigt, J.; Peters, B.; OConnor, S.E.
Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme
J. Am. Chem. Soc.
130
710-723
2008
BRENDA: Catharanthus roseus, Rauvolfia serpentina (P68175)
Textmining: plant
Sohani, M.M.; Schenk, P.M.; Schultz, C.J.; Schmidt, O.
Phylogenetic and transcriptional analysis of a strictosidine synthase-like gene family in Arabidopsis thaliana reveals involvement in plant defence responses
Plant Biol.
11
105-117
2009
Arabidopsis thaliana, Arabidopsis thaliana (Q9CAZ7), Arabidopsis thaliana (Q9SD04), Arabidopsis thaliana (Q9SD05), Arabidopsis thaliana (Q9SD07)
Stoeckigt, J.; Barleben, L.; Panjikar, S.; Loris, E.A.
3D-Structure and function of strictosidine synthase - the key enzyme of monoterpenoid indole alkaloid biosynthesis
Plant Physiol. Biochem.
46
340-355
2008
BRENDA: Catharanthus roseus (P18417), Rauvolfia serpentina (P68175), Rauvolfia serpentina
Textmining: plant
Chen, R.; Liao, Z.H.; Chen, M.; Wang, Q.; Yang, C.X.; Yang, Y.J.
Molecular cloning and characterization of the strictosidine synthase gene from Rauwolfia verticillata
Russ. J. Plant Physiol.
55
670-675
2008
Rauvolfia verticillata (Q1L6F4)
-
Yang, L.; Zou, H.; Zhu, H.; Ruppert, M.; Gong, J.; Stoeckigt, J.
Improved expression of His(6)-tagged strictosidine synthase cDNA for chemo-enzymatic alkaloid diversification
Chem. Biodivers.
7
860-870
2010
BRENDA: Rauvolfia serpentina (P68175)
Textmining: Escherichia coli, plant
Lu, Y.; Wang, H.; Wang, W.; Qian, Z.; Li, L.; Wang, J.; Zhou, G.; Kai, G.
Molecular characterization and expression analysis of a new cDNA encoding strictosidine synthase from Ophiorrhiza japonica
Mol. Biol. Rep.
36
1845-1852
2009
BRENDA: Ophiorrhiza japonica
Textmining: plant
Stockigt, J.; Hammes, B.; Ruppert, M.
Construction and expression of a dual vector for chemo-enzymatic synthesis of plant indole alkaloids in Escherichia coli
Nat. Prod. Res.
24
759-766
2010
BRENDA: Rauvolfia serpentina
Textmining: plant, Escherichia coli
Bernhardt, P.; OConnor, S.E.
Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry
Tetrahedron Lett.
50
7118-7120
2009
Rauvolfia serpentina (P68175)
Guirimand, G.; Courdavault, V.; Lanoue, A.; Mahroug, S.; Guihur, A.; Blanc, N.; Giglioli-Guivarch, N.; St-Pierre, B.; Burlat, V.
Strictosidine activation in Apocynaceae: Towards a nuclear time bomb?
BMC Plant Biol.
10
182
2010
BRENDA: Catharanthus roseus
Textmining: Apocynaceae, Brassicaceae, Rauvolfia serpentina (Q8GU20), Rauvolfia serpentina, plant
Kusari, S.; Zuehlke, S.; Spiteller, M.
Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis
J. Nat. Prod.
74
764-775
2011
Camptotheca acuminata
Yamazaki, M.; Asano, T.; Yamazaki, Y.; Sirikantaramas, S.; Sudo, H.; Saito, K.
Biosynthetic system of camptothecin: An anticancer plant product
Pure Appl. Chem.
82
213-218
2010
Ophiorrhiza pumila (Q94LW9)
-
Fischereder, E.; Pressnitz, D.; Kroutil, W.; Lutz, S.
Engineering strictosidine synthase: rational design of a small, focused circular permutation library of the beta-propeller fold enzyme
Bioorg. Med. Chem.
22
5633-5637
2014
BRENDA: Rauvolfia serpentina
Textmining: plant
Vera-Reyes, I.; Huerta-Heredia, A.A.; Ponce-Noyola, T.; Flores-Sanchez, I.J.; Esparza-Garcia, F.; Cerda-Garcia-Rojas, C.M.; Trejo-Tapia, G.; Ramos-Valdivia, A.C.
Strictosidine-related enzymes involved in the alkaloid biosynthesis of Uncaria tomentosa root cultures grown under oxidative stress
Biotechnol. Prog.
29
621-630
2013
Uncaria tomentosa
Verma, P.; Sharma, A.; Khan, S.A.; Shanker, K.; Mathur, A.K.
Over-expression of Catharanthus roseus tryptophan decarboxylase and strictosidine synthase in rol gene integrated transgenic cell suspensions of Vinca minor
Protoplasma
252
373-381
2015
BRENDA: Catharanthus roseus (P18417), Catharanthus roseus
Textmining: Vinca minor, Agrobacterium, plant
Pandey, S.S.; Singh, S.; Babu, C.S.; Shanker, K.; Srivastava, N.K.; Shukla, A.K.; Kalra, A.
Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis
Sci. Rep.
6
26583
2016
Catharanthus roseus (P18417), Catharanthus roseus
Cui, L.; Ni, X.; Ji, Q.; Teng, X.; Yang, Y.; Wu, C.; Zekria, D.; Zhang, D.; Kai, G.
Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila
Sci. Rep.
5
8227
2015
BRENDA: Catharanthus roseus (P18417), Catharanthus roseus
Textmining: Ophiorrhiza pumila
Zhu, H.; Kercmar, P.; Wu, F.; Rajendran, C.; Sun, L.; Wang, M.; Stoeckigt, J.
Using strictosidine synthase to prepare novel alkaloids
Curr. Med. Chem.
22
1880-1888
2015
Rauvolfia serpentina (P68175)
Sharma, A.; Verma, P.; Mathur, A.; Mathur, A.K.
Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus
Protoplasma
255
1281-1294
2018
BRENDA: Catharanthus roseus (P18417), Catharanthus roseus
Textmining: plant
Zou, T.; Li, S.; Liu, M.; Wang, T.; Xiao, Q.; Chen, D.; Li, Q.; Liang, Y.; Zhu, J.; Liang, Y.; Deng, Q.; Wang, S.; Zheng, A.; Wang, L.; Li, P.
An atypical strictosidine synthase, OsSTRL2, plays key roles in anther development and pollen wall formation in rice
Sci. Rep.
7
6863
2017
BRENDA: Oryza sativa (Q84Q89), Oryza sativa
Textmining: Embryophyta
Soltani, N.; Nazarian-Firouzabadi, F.; Shafeinia, A.; Sadr, A.S.; Shirali, M.
The expression of terpenoid indole alkaloid (TIAs) pathway genes in Catharanthus roseus in response to salicylic acid treatment
Mol. Biol. Rep.
47
7009-7016
2020
Catharanthus roseus (P18417), Catharanthus roseus
Eilert, U; De Luca, V; Constabel, F; Kurz, WG
Elicitor-mediated induction of tryptophan decarboxylase and strictosidine synthase activities in cell suspension cultures of Catharanthus roseus.
Arch Biochem Biophys
254
491-7
1987
Catharanthus roseus, Pythium, Pythium aphanidermatum
Doireau, P; Meriollon, JM; Guillot, A; Rideau, M; Chenieux, JC; Brillard, M
Time-Course Studies in Indole Alkaloid Accumulation and Changes in Tryptophan Decarboxylase and Strictosidine Synthase Activities: A Comparison in Three Strains of Catharanthus roseus Cells.
Planta Med
53
364-7
1987
Catharanthus roseus
Liu, W; Chen, R; Chen, M; Zhang, H; Peng, M; Yang, C; Ming, X; Lan, X; Liao, Z
Tryptophan decarboxylase plays an important role in ajmalicine biosynthesis in Rauvolfia verticillata.
Planta
2012
Rauvolfia
Roewer, IA; Cloutier, N; Nessler, CL; De Luca, V
Transient induction of tryptophan decarboxylase (TDC) and strictosidine synthase (SS) genes in cell suspension cultures of Catharanthus roseus.
Plant Cell Rep
11
86-9
1992
Catharanthus roseus, Pythium aphanidermatum
Hallard, D; van der Heijden, R; Verpoorte, R; Cardoso, MIL; Pasquali, G; Memelink, J; Hoge, JHC
Suspension cultured transgenic cells of Nicotiana tabacum expressing tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus produce strictosidine upon secologanin feeding.
Plant Cell Rep
17
50-54
1997
Catharanthus roseus, Nicotiana tabacum
Geerlings, A; Hallard, D; Martinez Caballero, A; Lopes Cardoso, I; van der Heijden, R; Verpoorte, R
Alkaloid production by a Cinchona officinalis 'Ledgeriana' hairy root culture containing constitutive expression constructs of tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus.
Plant Cell Rep
19
191-196
1999
Catharanthus roseus, Cinchona officinalis, Cinchona calisaya
Wang, M; Zi, J; Zhu, J; Chen, S; Wang, P; Song, L; Yu, R
Artemisinic Acid Serves as a Novel ORCA3 Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells.
Nat Prod Commun
11
715-7
2016
Catharanthus roseus, Catharanthus
McKnight, TD; Roessner, CA; Devagupta, R; Scott, AI; Nessler, CL
Nucleotide sequence of a cDNA encoding the vacuolar protein strictosidine synthase from Catharanthus roseus.
Nucleic Acids Res
18
4939
1990
Catharanthus roseus
Kutchan, TM
Expression of enzymatically active cloned strictosidine synthase from the higher plant Rauvolfia serpentina in Escherichia coli.
FEBS Lett
257
127-30
1989
Escherichia coli, Rauvolfia serpentina, plant, Bacteria
Kutchan, TM; Hampp, N; Lottspeich, F; Beyreuther, K; Zenk, MH
The cDNA clone for strictosidine synthase from Rauvolfia serpentina. DNA sequence determination and expression in Escherichia coli.
FEBS Lett
237
40-4
1988
Escherichia, Escherichia coli, Rauvolfia serpentina
Ouwerkerk, PB; Memelink, J
A G-box element from the Catharanthus roseus strictosidine synthase (Str) gene promoter confers seed-specific expression in transgenic tobacco plants.
Mol Gen Genet
261
635-43
1999
Catharanthus roseus, Nicotiana tabacum, Cauliflower mosaic virus
Sibéril, Y; Benhamron, S; Memelink, J; Giglioli-Guivarc'h, N; Thiersault, M; Boisson, B; Doireau, P; Gantet, P
Catharanthus roseus G-box binding factors 1 and 2 act as repressors of strictosidine synthase gene expression in cell cultures.
Plant Mol Biol
45
477-88
2001
Catharanthus roseus, plant
Wang, M; Li, QR
Transient expression of strictosidine synthase in tobacco leaves by vacuum infiltration.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)
34
703-6
2002
Nicotiana tabacum
Chatel, G; Montiel, G; Pré, M; Memelink, J; Thiersault, M; Saint-Pierre, B; Doireau, P; Gantet, P
CrMYC1, a Catharanthus roseus elicitor- and jasmonate-responsive bHLH transcription factor that binds the G-box element of the strictosidine synthase gene promoter.
J Exp Bot
54
2587-8
2003
Catharanthus roseus, Saccharomyces cerevisiae
Pfitzner, U; Zenk, MH
Homogeneous Strictosidine Synthase Isoenzymes from Cell Suspension Cultures of Catharanthus roseus.
Planta Med
55
525-530
1989
Catharanthus roseus
McKnight, TD; Bergey, DR; Burnett, RJ; Nessler, CL
Expression of enzymatically active and correctly targeted strictosidine synthase in transgenic tobacco plants.
Planta
185
148-52
1991
Nicotiana tabacum, Catharanthus roseus
Bracher, D; Kutchan, TM
Polymerase chain reaction comparison of the gene for strictosidine synthase from ten Rauvolfia species.
Plant Cell Rep
11
179-82
1992
Rauvolfia, Rauvolfia serpentina, Rauvolfia mannii, Rosa chinensis, Rasbora sumatrana, Rauvolfia cambodiana, Ramirezella nitida, Rhinusa canescens, Ramaria praecox, Rhamnus heterophylla
Sahay, A; Piprodhe, A; Pise, M
In silico analysis and homology modeling of strictosidine synthase involved in alkaloid biosynthesis in catharanthus roseus.
J Genet Eng Biotechnol
18
44
2020
Catharanthus roseus
Moreno, PR; Schlatmann, JE; van der Heijden, R; van Gulik, WM; ten Hoopen, HJ; Verpoorte, R; Heijnen, JJ
Induction of ajmalicine formation and related enzyme activities in Catharanthus roseus cells: effect of inoculum density.
Appl Microbiol Biotechnol
39
42-7
1993
Catharanthus roseus
Leech, MJ; May, K; Hallard, D; Verpoorte, R; De Luca, V; Christou, P
Expression of two consecutive genes of a secondary metabolic pathway in transgenic tobacco: molecular diversity influences levels of expression and product accumulation.
Plant Mol Biol
38
765-74
1998
Nicotiana tabacum, Catharanthus roseus
Menke, FL; Parchmann, S; Mueller, MJ; Kijne, JW; Memelink, J
Involvement of the octadecanoid pathway and protein phosphorylation in fungal elicitor-induced expression of terpenoid indole alkaloid biosynthetic genes in catharanthus roseus
Plant Physiol
119
1289-96
1999
Catharanthus roseus
Yamazaki, Y; Sudo, H; Yamazaki, M; Aimi, N; Saito, K
Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds.
Plant Cell Physiol
44
395-403
2003
Escherichia coli, Ophiorrhiza pumila, plant
Pauw, B; Hilliou, FA; Martin, VS; Chatel, G; de Wolf, CJ; Champion, A; Pré, M; van Duijn, B; Kijne, JW; van der Fits, L; Memelink, J
Zinc finger proteins act as transcriptional repressors of alkaloid biosynthesis genes in Catharanthus roseus.
J Biol Chem
279
52940-8
2004
Catharanthus roseus, Saccharomyces cerevisiae
De Luca, V; Fernandez, JA; Campbell, D; Kurz, WG
Developmental Regulation of Enzymes of Indole Alkaloid Biosynthesis in Catharanthus roseus.
Plant Physiol
86
447-450
1988
Catharanthus roseus
Ramani, S; Chelliah, J
UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures.
BMC Plant Biol
7
61
2007
Catharanthus roseus, plant
Pasquali, G; Goddijn, OJ; de Waal, A; Verpoorte, R; Schilperoort, RA; Hoge, JH; Memelink, J
Coordinated regulation of two indole alkaloid biosynthetic genes from Catharanthus roseus by auxin and elicitors.
Plant Mol Biol
18
1121-31
1992
Catharanthus roseus, Saccharomyces cerevisiae, Pythium aphanidermatum
Pauw, B; van Duijn, B; Kijne, JW; Memelink, J
Activation of the oxidative burst by yeast elicitor in Catharanthus roseus cells occurs independently of the activation of genes involved in alkaloid biosynthesis.
Plant Mol Biol
55
797-805
2004
Catharanthus roseus, Saccharomyces cerevisiae
Jacobs, DI; Gaspari, M; van der Greef, J; van der Heijden, R; Verpoorte, R
Proteome analysis of the medicinal plant Catharanthus roseus.
Planta
221
690-704
2005
Catharanthus roseus, plant
Wungsintaweekul, J; Choo-Malee, J; Charoonratana, T; Keawpradub, N
Methyl jasmonate and yeast extract stimulate mitragynine production in Mitragyna speciosa (Roxb.) Korth. shoot culture.
Biotechnol Lett
2012
Saccharomyces cerevisiae, Mitragyna speciosa
Pan, YJ; Liu, J; Guo, XR; Zu, YG; Tang, ZH
Gene transcript profiles of the TIA biosynthetic pathway in response to ethylene and copper reveal their interactive role in modulating TIA biosynthesis in Catharanthus roseus.
Protoplasma
2014
Catharanthus roseus
Sharma, A; Verma, P; Mathur, A; Mathur, AK
Genetic engineering approach using early Vinca alkaloid biosynthesis genes led to increased tryptamine and terpenoid indole alkaloids biosynthesis in differentiating cultures of Catharanthus roseus.
Protoplasma
2017
Agrobacterium tumefaciens, Transformation
Zhou, ML; Hou, HL; Zhu, XM; Shao, JR; Wu, YM; Tang, YX
Soybean transcription factor GmMYBZ2 represses catharanthine biosynthesis in hairy roots of Catharanthus roseus.
Appl Microbiol Biotechnol
91
1095-105
2011
Catharanthus
Geerlings, A; Redondo, FJ; Contin, A; Memelink, J; van der Heijden, R; Verpoorte, R
Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast.
Appl Microbiol Biotechnol
56
420-4
2001
Saccharomyces cerevisiae, plant, Catharanthus roseus, Symphoricarpos
Singh, SK; Patra, B; Paul, P; Liu, Y; Pattanaik, S; Yuan, L
Revisiting the ORCA gene cluster that regulates terpenoid indole alkaloid biosynthesis in Catharanthus roseus.
Plant Sci
293
110408
2020
Nicotiana tabacum
Deus-Neumann, B; Zenk, MH
A highly selective alkaloid uptake system in vacuoles of higher plants.
Planta
162
250-60
1984
Catharanthus roseus
Theopold, U; Samakovlis, C; Erdjument-Bromage, H; Dillon, N; Axelsson, B; Schmidt, O; Tempst, P; Hultmark, D
Helix pomatia lectin, an inducer of Drosophila immune response, binds to hemomucin, a novel surface mucin.
J Biol Chem
271
12708-15
1996
plant
Fabbri, M; Delp, G; Schmidt, O; Theopold, U
Animal and plant members of a gene family with similarity to alkaloid-synthesizing enzymes.
Biochem Biophys Res Commun
271
191-6
2000
animal, plant, Arabidopsis, Caenorhabditis, Homo sapiens, Mus musculus, Drosophila
van der Fits, L; Zhang, H; Menke, FL; Deneka, M; Memelink, J
A Catharanthus roseus BPF-1 homologue interacts with an elicitor-responsive region of the secondary metabolite biosynthetic gene Str and is induced by elicitor via a JA-independent signal transduction pathway.
Plant Mol Biol
44
675-85
2000
Catharanthus roseus, plant, Petroselinum crispum, Saccharomyces cerevisiae
Mathieu, M; Winters, EK; Kong, F; Wan, J; Wang, S; Eckert, H; Luth, D; Paz, M; Donovan, C; Zhang, Z; Somers, D; Wang, K; Nguyen, H; Shoemaker, RC; Stacey, G; Clemente, T
Establishment of a soybean (Glycine max Merr. L) transposon-based mutagenesis repository.
Planta
229
279-89
2009
Glycine max, transposons, Medicago truncatula, collection
Aerts, RJ; de Waal, A; Pennings, EJ; Verpoorte, R
The distribution of strictosidine-synthase activity and alkaloids in Cinchona plants.
Planta
183
536-41
1991
Cinchona, Cinchona calisaya, plant
Chen, L; Meng, J; Luan, Y
miR1916 plays a role as a negative regulator in drought stress resistance in tomato and tobacco.
Biochem Biophys Res Commun
508
597-602
2019
Nicotiana tabacum
Cardoso, MIL; Meijer, AH; Hoge, JHC
Agrobacterium-mediated transformation of the terpenoid indole alkaloid-producing plant species Tabernaemontana pandacaqui.
Plant Cell Rep
17
150-154
1997
Apocynaceae, Catharanthus roseus
Kibble, NAJ; Sohani, MM; Shirley, N; Byrt, C; Roessner, U; Bacic, A; Schmidt, O; Schultz, CJ
Phylogenetic analysis and functional characterisation of strictosidine synthase-like genes in Arabidopsis thaliana.
Funct Plant Biol
36
1098-1109
2010
Escherichia coli, Arabidopsis
Kibble NatalieAJ;Sohani MMehdi;Shirley Neil;Byrt Caitlin;Roessner Ute;Bacic Antony;Schmidt Otto;Schultz CarolynJ
Phylogenetic analysis and functional characterisation of strictosidine synthase-like genes in Arabidopsis thaliana
Functional plant biology : FPB
36
1098-1109
2009
Escherichia coli, Arabidopsis
Walton, NJ; Skinner, SE; Robins, RJ; Rhodes, MJ
A spectrophotometric assay for strictosidine synthase.
Anal Biochem
163
482-8
1987
Cinchona calisaya
Cao, N; Wang, CH
Strictosidine synthase, an indispensable enzyme involved in the biosynthesis of terpenoid indole and ?-carboline alkaloids.
Chin J Nat Med
19
591-607
2021
plant
Wu, F; Ker?mar, P; Zhang, C; Stckigt, J
Sarpagan-Ajmalan-Type Indoles: Biosynthesis, Structural Biology, and Chemo-Enzymatic Significance.
Alkaloids Chem Biol
76
1-61
2016
Rauvolfia
Kutchan, TM
Strictosidine: from alkaloid to enzyme to gene.
Phytochemistry
32
493-506
1993
plant
Menke, FL; Champion, A; Kijne, JW; Memelink, J
A novel jasmonate- and elicitor-responsive element in the periwinkle secondary metabolite biosynthetic gene Str interacts with a jasmonate- and elicitor-inducible AP2-domain transcription factor, ORCA2.
EMBO J
18
4455-63
1999
Catharanthus roseus, Catharanthus, Saccharomyces cerevisiae, plant
Morita, M; Hara, Y; Tamai, Y; Arakawa, H; Nishimura, S
Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3).
Genomics
67
87-91
2000
Homo sapiens, plant
Bachmann, BO
Foundations for directed alkaloid biosynthesis.
Chem Biol
14
875-6
2007
plant
Bernhardt, P; Usera, AR; O'Connor, SE
Biocatalytic asymmetric formation of tetrahydro-beta-carbolines.
Tetrahedron Lett
51
4400-4402
2010
Ophiorrhiza pumila
Zou, HB; Zhu, HJ; Zhang, L; Yang, LQ; Yu, YP; Stckigt, J
A facile chemoenzymatic approach: one-step syntheses of monoterpenoid indole alkaloids.
Chem Asian J
5
2400-4
2010
Rauvolfia
html completed
