Reference on EC 4.3.2.1 - argininosuccinate lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Raushel, F.M.
Nitro analogs of substrates for argininosuccinate synthetase and argininosuccinate lyase
Arch. Biochem. Biophys.
232
520-525
1984
Bos taurus
Matuo, S.; Tatsuno, M.; Kobayashi, K.; Saheki, T.; Miyata, T.; Iwanaga, S.; Amaya, Y.; Mori, M.
Isolation of cDNA clones of human argininosuccinate lyase and corrected amino acid sequence
FEBS Lett.
234
395-399
1988
Homo sapiens
Miura, T.; Kashiwamura, M.; Kimura, M.
An enzymatic method for the assay of serum argininosuccinate lyase
Anal. Biochem.
164
482-487
1987
Homo sapiens, Sus scrofa
Lusty, C.J.; Ratner, S.
Reaction of argininosuccinase with bromomesaconic acid: role of an essential lysine in the active site
Proc. Natl. Acad. Sci. USA
84
3176-3180
1987
Bos taurus
Farrell, K.; Overton, S.
Characterization of argininosuccinate lyase (EC 4.3.2.1) from Chlamydomonas reinhardtii
Biochem. J.
242
261-266
1987
Chlamydomonas reinhardtii
O'Brien, W.E.; McInnes, R.; Kalumuck, K.; Adcock, M.
Cloning and sequence analysis of cDNA for human argininosuccinate lyase
Proc. Natl. Acad. Sci. USA
83
7211-7215
1986
Saccharomyces cerevisiae, Homo sapiens
Garrard, L.J.; Bui, Q.T.N.; Nygaard, R.; Raushel, F.M.
Acid-base catalysis in the argininosuccinate lyase reaction
J. Biol. Chem.
260
5548-5553
1985
Bos taurus
Garred, L.J.; Mathis, J.M.; Raushel, F.M.
Substrate-induced inactivation of argininosuccinate lyase by monofluorofumarate and difluorofumarate
Biochemistry
22
3729-3735
1983
Bos taurus
Raushel, F.M.; Nygaard, R.
Kinetic mechanism of bovine liver argininosuccinate lyase
Arch. Biochem. Biophys.
221
143-147
1983
Bos taurus
Palekar, A.G.; Mantagos, S.
Human liver arginiosuccinase purification and partial characterization
J. Biol. Chem.
256
9192-9194
1981
Homo sapiens
O'Brien, W.E.; Barr, R.H.
Argininosuccinate lyase: purification and characterization from human liver
Biochemistry
20
2056-2060
1981
Homo sapiens
Murakami-Murofushi, K.; Rainer, S.
Argininosuccinase from bovine brain: isolation and comparison of catalytic, physical, and chemical properties with the enzymes from liver and kidney
Anal. Biochem.
95
139-155
1979
Bos taurus
Matagne, R.F.; Schlsser, J.P.
Purification and subunit structure of argininosuccinate lyase from Chlamydomonas reinhardi
Biochem. J.
167
71-75
1977
Chlamydomonas reinhardtii
Menyhart, J.; Grof, J.
Urea as a selective inhibitor of argininosuccinate lyase
Eur. J. Biochem.
75
405-409
1977
Rattus norvegicus
Rochovansky, O.
On the role of substrate and GTP in the regulation of argininosuccinase activity
J. Biol. Chem.
250
7225-72300
1975
Bos taurus
Lusty, C.J.; Ratner, S.
Biosynthesis of urea. XIV. The quaternary structure of argininosuccinase
J. Biol. Chem.
247
7010-7022
1972
Bos taurus
Bray, R.C.; Ratner, S.
Argininosuccinase from bovine kidney: comparison of catalytic, physical, and chemical properties with the enzyme from bovine liver
Arch. Biochem. Biophys.
146
531-541
1971
Bos taurus
Wu, C.Y.; Lee, H.J.; Wu, S.H.; Chen, S.T.; Chiou, S.H.; Chang, G.G.
Chemical mechanism of the endogenous argininosuccinate lyase activity of duck lens delta2-crystallin
Biochem. J.
333
327-334
1998
Anas platyrhynchos
Piatigorsky, J.; Horwitz, J.
Characterization and enzyme activity of argininosuccinate lyase/delta-crystallin of the embryonic duck lens
Biochim. Biophys. Acta
1295
158-164
1996
Anas platyrhynchos
Auchincloss, A.H.; Loroch, A.I.; Rochaix, J.D.
The argininosuccinate lyase gene of Chlamydomonas reinhardtii: cloning of the cDNA and its characterization as a selectable shuttle marker
Mol. Gen. Genet.
261
21-30
1999
Chlamydomonas reinhardtii
Matsubasa, T.; Takiguchi, M.; Amaya, Y.; Matsuda, I.; Mori, M.
Structure of the rat argininosuccinate lyase gene: close similarity to chicken delta-crystallin genes
Proc. Natl. Acad. Sci. USA
86
592-596
1989
Gallus gallus, Rattus norvegicus
Kondoh, H.; Araki, I.; Yasuda, K.; Matsubasa, T.; Mori, M.
Expression of the chicken delta 2-crystallin gene in mouse cells: evidence for encoding of argininosuccinate lyase
Gene
99
267-271
1991
Gallus gallus
Turner, M.A.; Achyuthan, A.M.; Hershfield, M.S.; McInnes, R.R.; Howell, P.L.
Expression, purification, crystallization and preliminary X-ray analysis of human argininosuccinic acid lyase
J. Mol. Biol.
239
336-338
1994
Homo sapiens
Chiou, S.H.; Lee, H.J.; Chu, H.; Lai, T.A.; Chang, G.G.
Screening and kinetic analysis of delta-crystallins with endogenous argininosuccinate lyase activity in the lenses of vertebrates
Biochem. Int.
25
705-713
1991
Anas platyrhynchos, Anser sp., Gallus gallus
Voorter, C.E.M.; Salemink, I.; de Jong, W.W.
delta-Crystallin is more thermostable than mammalian argininosuccinate lyase
Exp. Eye Res.
56
733-735
1993
Anas platyrhynchos, Bos taurus, Sus scrofa
Barbosa, P.; Wistow, G.J.; Cialkowski, M.; Piatigorsky, J.; O'Brien, W.E.
Expression of duck lens delta-crystallin cDNAs in yeast and bacterial hosts
J. Biol. Chem.
266
2319-2322
1991
Anas platyrhynchos
-
Lee, H.J.; Lin, C.C.; Chiou, S.H.; Chang, G.G.
Characterization of the multiple forms of duck lens delta-crystallin with endogenous argininosuccinate lyase activity
Arch. Biochem. Biophys.
314
31-38
1994
Anas platyrhynchos
Lee, H.J.; Chiou, S.H.; Chang, G.G.
Inactivation of the endogenous argininosuccinate lyase activity of duck delta-crystallin by modification of an essential histidine residue with diethyl pyrocarbonate
Biochem. J.
293
537-544
1993
Anas platyrhynchos
Chakraborty, A.R.; Davidson, A.; Howell, P.L.
Mutational analysis of amino acid residues involved in argininosuccinate lyase activity in duck delta II crystallin
Biochemistry
38
2435-2443
1999
Anas platyrhynchos, Homo sapiens
Sampaleanu, L.M.; Vallee, F.; Thompson, G.D.; Howell, P.L.
Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R
Biochemistry
40
15570-15580
2001
Homo sapiens
Yu, B.; Thompson, G.D.; Yip, P.; Howell, P.L.; Davidson, A.R.
Mechanisms for intragenic complementation at the human argininosuccinate lyase locus
Biochemistry
40
15581-15590
2001
Homo sapiens
Braissant, O.; Gotoh, T.; Loup, M.; Mori, M.; Bachmann, C.
L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study
Brain Res. Mol. Brain Res.
70
231-241
1999
Rattus norvegicus
Yu, B.; Howell, P.L.
Intragenic complementation and the structure and function of argininosuccinate lyase
Cell. Mol. Life Sci.
57
1637-1651
2000
Homo sapiens
Troshina, O.; Hansel, A.; Lindblad, P.
Cloning, characterization, and functional expression in Escherichia coli of argH encoding argininosuccinate lyase in the cyanobacterium Nostoc sp. strain PCC 73102
Curr. Microbiol.
43
260-264
2001
Nostoc sp. (Q9LAE5), Nostoc sp.
Van Geldre, L.A.; Timmermans, J.P.; Lefebvre, R.A.
L-citrulline recycling by argininosuccinate synthetase and lyase in rat gastric fundus
Eur. J. Pharmacol.
455
149-160
2002
Rattus norvegicus
Cohen-Kupiec, R.; Kupiec, M.; Sandbeck, K.; Leigh, J.A.
Functional conservation between the argininosuccinate lyase of the archaeon Methanococcus maripaludis and the corresponding bacterial and eukaryal genes
FEMS Microbiol. Lett.
173
231-238
1999
Methanococcus maripaludis
Sampaleanu, L.M.; Yu, B.; Howell, P.L.
Mutational analysis of duck delta 2 crystallin and the structure of an inactive mutant with bound substrate provide insight into the enzymatic mechanism of argininosuccinate lyase
J. Biol. Chem.
277
4166-4175
2002
Anas platyrhynchos
Latasa, M.U.; Carretero, M.V.; Garcia-Trevijano, E.R.; Torres, L.; Mato, J.M.; Avila, M.A.
Identification of argininosuccinate lyase as a hypoxia-responsive gene in rat hepatocytes
J. Hepatol.
33
709-715
2000
Rattus norvegicus
Linnebank, M.; Homberger, A.; Rapp, B.; Winter, C.; Marquardt, T.; Harms, E.; Koch, H.G.
Two novel mutations (E86A, R113W) in argininosuccinate lyase deficiency and evidence for highly variable splicing of the human argininosuccinate lyase gene
J. Inherit. Metab. Dis.
23
308-312
2000
Homo sapiens
Daniel, E.E.; Wang, Y.F.; Salapatek, A.M.; Mao, Y.K.; Mori, M.
Arginosuccinate synthetase, arginosuccinate lyase and NOS in canine gastroinestinal tract
Neurogastroenterol. Motil.
12
317-334
2000
Canis lupus familiaris
Bhaumik, P.; Koski, M.K.; Bergmann, U.; Wierenga, R.K.
Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli
Acta Crystallogr. Sect. D
60
1964-1970
2004
Escherichia coli
Tsai, M.; Sampaleanu, L.M.; Greene, C.; Creagh, L.; Haynes, C.; Howell, P.L.
A duck delta1 crystallin double loop mutant provides insight into residues important for argininosuccinate lyase activity
Biochemistry
43
11672-11682
2004
Anas sp.
Tsai, M.; Koo, J.; Howell, P.L.
Recovery of argininosuccinate lyase activity in duck delta1 crystallin
Biochemistry
44
9034-9044
2005
Anas sp.
Yim, S.H.; Lee, M.S.
Molecular cloning and analysis of the argH gene encoding argininosuccinate lyase from Corynebacterium glutamicum
Korean J. Genet.
27
25-33
2005
Corynebacterium glutamicum
-
Bizzoco, E.; Vannucchi, M.G.; Faussone-Pellegrini, M.S.
Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons
Exp. Neurol.
204
252-259
2007
Rattus norvegicus
Wagemaker, M.J.; Eastwood, D.C.; van der Drift, C.; Jetten, M.S.; Burton, K.; Van Griensven, L.J.; Op den Camp, H.J.
Argininosuccinate synthetase and argininosuccinate lyase: two ornithine cycle enzymes from Agaricus bisporus
Mycol. Res.
111
493-502
2007
Agaricus bisporus (Q9P870), Agaricus bisporus
Bizzoco, E.; Faussone-Pellegrini, M.S.; Vannucchi, M.G.
Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia
Exp. Neurol.
208
100-109
2007
Rattus norvegicus
Tischner, R.; Galli, M.; Heimer, Y.M.; Bielefeld, S.; Okamoto, M.; Mack, A.; Crawford, N.M.
Interference with the citrulline-based nitric oxide synthase assay by argininosuccinate lyase activity in Arabidopsis extracts
FEBS J.
274
4238-4245
2007
Arabidopsis thaliana
Lam, T.L.; Wong, G.K.; Chong, H.C.; Cheng, P.N.; Choi, S.C.; Chow, T.L.; Kwok, S.Y.; Poon, R.T.; Wheatley, D.N.; Lo, W.H.; Leung, Y.C.
Recombinant human arginase inhibits proliferation of human hepatocellular carcinoma by inducing cell cycle arrest
Cancer Lett.
277
91-100
2009
Homo sapiens
Mitchell, S.; Ellingson, C.; Coyne, T.; Hall, L.; Neill, M.; Christian, N.; Higham, C.; Dobrowolski, S.F.; Tuchman, M.; Summar, M.; Summar, M.
Genetic variation in the urea cycle: a model resource for investigating key candidate genes for common diseases
Hum. Mutat.
30
56-60
2009
Homo sapiens
Takagi, M.; Yonezawa, T.; Haga, S.; Shingu, H.; Kobayashi, Y.; Takahashi, T.; Ohtani, Y.; Obara, Y.; Katoh, K.
Changes of activity and mRNA expression of urea cycle enzymes in the liver of developing Holstein calves
J. Anim. Sci.
86
1526-1532
2008
Bos taurus
Feng, J.F.; Chen, T.M.; Wen, Y.A.; Wang, J.; Tu, Z.G.
Study of serum argininosuccinate lyase determination for diagnosis of liver diseases
J. Clin. Lab. Anal.
22
220-227
2008
Homo sapiens
Laberge, T.; Walsh, P.J.; McDonald, M.D.
Effects of crowding on ornithine-urea cycle enzyme mRNA expression and activity in gulf toadfish (Opsanus beta)
J. Exp. Biol.
212
2394-2402
2009
Opsanus beta
Levillain, O.; Rabier, D.; Duclos, B.; Gaudreau, P.; Vinay, P.
L-Arginine metabolism in dog kidney and isolated nephron segments
Metab. Clin. Exp.
57
9-23
2008
Canis lupus familiaris
Bringel, F.; Hammann, P.; Kugler, V.; Arsene-Ploetze, F.
Lactobacillus plantarum response to inorganic carbon concentrations: PyrR2-dependent and -independent transcription regulation of genes involved in arginine and nucleotide metabolism
Microbiology
154
2629-2640
2008
Lactiplantibacillus plantarum
Eastwood, D.C.; Challen, M.P.; Zhang, C.; Jenkins, H.; Henderson, J.; Burton, K.S.
Hairpin-mediated down-regulation of the urea cycle enzyme argininosuccinate lyase in Agaricus bisporus
Mycol. Res.
112
708-716
2008
Agaricus bisporus (Q9P8B5), Agaricus bisporus
Nagasaka, H.; Tsukahara, H.; Yorifuji, T.; Miida, T.; Murayama, K.; Tsuruoka, T.; Takatani, T.; Kanazawa, M.; Kobayashi, K.; Okano, Y.; Takayanagi, M.
Evaluation of endogenous nitric oxide synthesis in congenital urea cycle enzyme defects
Metab. Clin. Exp.
58
278-282
2009
Homo sapiens
Chen, G.F.; Baylis, C.
In vivo renal arginine release is impaired throughout development of chronic kidney disease
Am. J. Physiol. Renal Physiol.
298
F95-102
2010
Rattus norvegicus
Swamy, M.; Sirajudeen, K.N.; Chandran, G.
Nitric oxide (NO), citrulline-NO cycle enzymes, glutamine synthetase, and oxidative status in kainic acid-mediated excitotoxicity in rat brain
Drug Chem. Toxicol.
32
326-331
2009
Rattus norvegicus
Trevisson, E.; Burlina, A.; Doimo, M.; Pertegato, V.; Casarin, A.; Cesaro, L.; Navas, P.; Basso, G.; Sartori, G.; Salviati, L.
Functional complementation in yeast allows molecular characterization of missense argininosuccinate lyase mutations
J. Biol. Chem.
284
28926-28934
2009
Saccharomyces cerevisiae, Homo sapiens (P04424), Homo sapiens
Mercimek-Mahmutoglu, S.; Moeslinger, D.; Haeberle, J.; Engel, K.; Herle, M.; Strobl, M.W.; Scheibenreiter, S.; Muehl, A.; Stoeckler-Ipsiroglu, S.
Long-term outcome of patients with argininosuccinate lyase deficiency diagnosed by newborn screening in Austria
Mol. Genet. Metab.
100
24-28
2010
Homo sapiens
Neill, M.A.; Aschner, J.; Barr, F.; Summar, M.L.
Quantitative RT-PCR comparison of the urea and nitric oxide cycle gene transcripts in adult human tissues
Mol. Genet. Metab.
97
121-127
2009
Homo sapiens
Chen, G.F.; Wagner, L.; Sasser, J.M.; Zharikov, S.; Moningka, N.C.; Baylis, C.
Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats
Nephrol. Dial. Transplant.
25
3518-3525
2010
Rattus norvegicus
Zhao, S.; Xu, W.; Jiang, W.; Yu, W.; Lin, Y.; Zhang, T.; Yao, J.; Zhou, L.; Zeng, Y.; Li, H.; Li, Y.; Shi, J.; An, W.; Hancock, S.; He, F.; Qin, L.; Chin, J.; Yang, P.; Chen, X.; Lei, Q.; Xiong, Y.; Guan, K.
Regulation of cellular metabolism by protein lysine acetylation
Science
327
1000-1004
2010
Homo sapiens
Sharma, S.; Kumar, S.; Sud, N.; Wiseman, D.A.; Tian, J.; Rehmani, I.; Datar, S.; Oishi, P.; Fratz, S.; Venema, R.C.; Fineman, J.R.; Black, S.M.
Alterations in lung arginine metabolism in lambs with pulmonary hypertension associated with increased pulmonary blood flow
Vascul. Pharmacol.
51
359-364
2009
Ovis aries
Cao, Y.L.; Li, G.L.; Wang, K.T.; Zhang, H.Y.; Li, L.F.
Crystallization and preliminary X-ray analysis of argininosuccinate lyase from Streptococcus mutans
Acta Crystallogr. Sect. F
67
682-684
2011
Streptococcus mutans (Q8DVX5), Streptococcus mutans
Chen, Y.H.; Lee, M.T.; Cheng, Y.W.; Chou, W.Y.; Yu, C.M.; Lee, H.J.
Distinct interactions of alphaA-crystallin with homologous substrate proteins, delta-crystallin and argininosuccinate lyase, under thermal stress
Biochimie
93
314-320
2011
Homo sapiens
Engel, K.; Vuissoz, J.; Eggimann, S.; Groux, M.; Berning, C.; Hu, L.; Klaus, V.; Moeslinger, D.; Mercimek-Mahmutoglu, S.; Stckler, S.; Wermuth, B.; Hberle, J.; Nuoffer, J.
Bacterial expression of mutant argininosuccinate lyase reveals imperfect correlation of in-vitro enzyme activity with clinical phenotype in argininosuccinic aciduria
J. Inherit. Metab. Dis.
35
133-140
2012
Homo sapiens
Van de Casteele, M.; Demarez, M.; Legrain, C.; Glansdorff, N.; Pierard, A.
Pathways of arginine biosynthesis in extreme thermophilic archaeo- and eubacteria
J. Gen. Microbiol.
136
1177-1183
1990
Pyrococcus furiosus, Saccharolobus solfataricus, Saccharolobus solfataricus P1
-
Paul, A.; Mishra, A.; Surolia, A.; Vijayan, M.
Cloning, expression, purification, crystallization and preliminary X-ray studies of argininosuccinate lyase (Rv1659) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
69
1422-1424
2013
Mycobacterium tuberculosis (P9WPY7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WPY7)
Premkumar, M.H.; Sule, G.; Nagamani, S.C.; Chakkalakal, S.; Nordin, A.; Jain, M.; Ruan, M.Z.; Bertin, T.; Dawson, B.; Zhang, J.; Schady, D.; Bryan, N.S.; Campeau, P.M.; Erez, A.; Lee, B.
Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis
Am. J. Physiol. Gastrointest. Liver Physiol.
307
G347-G354
2014
Mus musculus, Rattus norvegicus
Zheng, L.; Mackenzie, E.D.; Karim, S.A.; Hedley, A.; Blyth, K.; Kalna, G.; Watson, D.G.; Szlosarek, P.; Frezza, C.; Gottlieb, E.
Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells
Cancer Metab.
1
12
2013
Homo sapiens, Mus musculus
Han, X.; Sun, X.; Shan, X.; Zhang, M.; Song, J.; Tian, M.; Fan, G.; Wang, S.; Tong, Y.; Ding, C.; Yu, S.
In vivo-induced argininosuccinate lyase plays a role in the replication of Brucella abortus in RAW264.7 cells
Microbiology
160
567-575
2014
Mus musculus, Mus musculus BALB/c
Erez, A.; Nagamani, S.C.; Shchelochkov, O.A.; Premkumar, M.H.; Campeau, P.M.; Chen, Y.; Garg, H.K.; Li, L.; Mian, A.; Bertin, T.K.; Black, J.O.; Zeng, H.; Tang, Y.; Reddy, A.K.; Summar, M.; OBrien, W.E.; Harrison, D.G.; Mitch, W.E.; Marini, J.C.; Aschner, J.L.; Bryan, N.S.; Lee, B.
Requirement of argininosuccinate lyase for systemic nitric oxide production
Nat. Med.
17
1619-1626
2011
Homo sapiens, Mus musculus
Xia, J.; Yamaji, N.; Che, J.; Shen, R.F.; Ma, J.F.
Normal root elongation requires arginine produced by argininosuccinate lyase in rice
Plant J.
78
215-226
2014
Oryza sativa
Mishra, A.; Surolia, A.
Biochemical characterization of argininosuccinate lyase from M. tuberculosis significance of a c-terminal cysteine in catalysis and thermal stability
IUBMB Life
69
896-907
2017
Mycobacterium tuberculosis (P9WPY7), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WPY7)
Hu, L.; Pandey, A.V.; Balmer, C.; Eggimann, S.; Ruefenacht, V.; Nuoffer, J.M.; Haeberle, J.
Unstable argininosuccinate lyase in variant forms of the urea cycle disorder argininosuccinic aciduria
J. Inherit. Metab. Dis.
38
815-827
2015
Homo sapiens (P04424), Homo sapiens
Huang, H.L.; Chen, W.C.; Hsu, H.P.; Cho, C.Y.; Hung, Y.H.; Wang, C.Y.; Lai, M.D.
Argininosuccinate lyase is a potential therapeutic target in breast cancer
Oncol. Rep.
34
3131-3139
2015
Homo sapiens (P04424), Homo sapiens
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