Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 4.3.1.4 - formimidoyltetrahydrofolate cyclodeaminase and Organism(s) Homo sapiens and UniProt Accession O95954

for references in articles please use BRENDA:EC4.3.1.4
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     4 Lyases
         4.3 Carbon-nitrogen lyases
             4.3.1 Ammonia-lyases
                4.3.1.4 formimidoyltetrahydrofolate cyclodeaminase
IUBMB Comments
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Homo sapiens
UNIPROT: O95954
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
formiminotransferase cyclodeaminase, 58k golgi protein, formiminotetrahydrofolate cyclodeaminase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formiminotransferase cyclodeaminase
-
58K Golgi protein
-
-
deaminase, formiminotetrahydrofolate cyclo-
-
-
-
-
formimidoyltetrahydrofolate cyclodeaminase
-
-
formimino-THF cyclodeaminase
-
-
-
-
Formiminotetrahydrofolate cyclodeaminase
-
-
-
-
formiminotransferase cyclodeaminase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)
In eukaroytes, occurs as a bifunctional enzyme that also has glutamate formimidoyltransferase (EC 2.1.2.5) activity.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-05-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-formimidoyltetrahydrofolate
5,10-methenyltetrahydrofolate + NH3
show the reaction diagram
-
-
-
-
?
5-formiminotetrahydrofolate
5,10-methenyltetrahydrofolate + NH3
show the reaction diagram
5-formiminotetrahydrofolate
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
5-formimidoyltetrahydrofolate
5,10-methenyltetrahydrofolate + NH3
show the reaction diagram
-
-
-
-
?
5-formiminotetrahydrofolate
?
show the reaction diagram
-
-
-
-
?
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K+
-
activates
NH4+
-
activates
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
hepatocellular carcinoma tissue
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
association, binds reversibly
Manually annotated by BRENDA team
-
formiminotransferase-cyclodeaminase enzyme complex
Manually annotated by BRENDA team
-
Golgi apparatus, formiminotransferase-cyclodeaminase enzyme complex
Manually annotated by BRENDA team
additional information
no interaction aith liver-specific cytoskeleton proteins
-
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FTCD_HUMAN
541
0
58927
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
496000
sedimentation analysis
58000
8 * 58000, SDS-PAGE
58870
predicted and determined by immunoblot analysis of protein lysates
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homooctamer
8 * 58000, SDS-PAGE
oligomer
-
present in cells as an oligomer with a MG of 240000, each subunit has a MG of 62000, SDS-PAGE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
formiminotransferase-cyclodeaminase enzyme complex
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diagnostics
putative biomarker, FTCD is useful to distinguish early hepatocellular carcinoma from benign tumors such as regenerative nodule or focal nodular hyperplasia
medicine
autoantibodies of type 2 autoimmune hepatitis patients are directed against the mature, high-molecular form of enzyme
medicine
-
assay to determine N-formimino-L-glutamate in urine, blood and other fluids for folic acid deficiency
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cooperman, J.M.
Formimino-L-glutamate
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
8
514-521
1985
Homo sapiens, Rattus norvegicus
-
Manually annotated by BRENDA team
Hennig, D.; Scales, S.J.; Moreau, A.; Murley, L.L.; De Mey, J.; Kreis, T.E.
A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules
J. Biol. Chem.
273
19602-19611
1998
Canis lupus familiaris, Canis lupus familiaris Madin-Darby, Gallus gallus (Q9YH58), Gallus gallus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus, Sus scrofa (P53603)
Manually annotated by BRENDA team
Lapierre, P.; Hajoui, O.; Homberg, J.C.; Alvarez, F.
Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis
Gastroenterology
116
643-649
1999
Homo sapiens
Manually annotated by BRENDA team
Renous, R.; Lapierre, P.; Djilali-Saiah, I.; Vitozzi, S.; Alvarez, F.
Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis
Exp. Cell Res.
292
332-341
2004
Homo sapiens (O95954)
Manually annotated by BRENDA team
Hagiwara, H.; Tajika, Y.; Matsuzaki, T.; Suzuki, T.; Aoki, T.; Takata, K.
Localization of Golgi 58K protein (formiminotransferase cyclodeaminase) to the centrosome
Histochem. Cell Biol.
126
251-259
2006
Homo sapiens
Manually annotated by BRENDA team
Seimiya, M.; Tomonaga, T.; Matsushita, K.; Sunaga, M.; Oh-Ishi, M.; Kodera, Y.; Maeda, T.; Takano, S.; Togawa, A.; Yoshitomi, H.; Otsuka, M.; Yamamoto, M.; Nakano, M.; Miyazaki, M.; Nomura, F.
Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma; clathrin heavy chain and formiminotransferase cyclodeaminase
Hepatology
48
519-530
2008
Homo sapiens (O95954), Homo sapiens
Manually annotated by BRENDA team