Information on EC 4.3.1.31 - L-tryptophan ammonia lyase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Rubrivivax benzoatilyticus

EC NUMBER
COMMENTARY hide
4.3.1.31
-
RECOMMENDED NAME
GeneOntology No.
L-tryptophan ammonia lyase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-tryptophan = 3-indoleacrylate + ammonia
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-tryptophan ammonia-lyase (3-indoleacrylate-forming)
The enzyme, characterized from the bacterium Rubrivivax benzoatilyticus JA2, requires no cofactors. It acts on L-phenylalanine and L-glutamate with about 60% of the activity with L-tryptophan, and on L-tyrosine, glycine, and L-alanine with about 30% of the activity.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glycine
?
show the reaction diagram
-
about 30% of the activity with L-tryptophan
-
-
?
L-alanine
?
show the reaction diagram
L-glutamate
?
show the reaction diagram
-
about 60% of the activity with L-tryptophan
-
-
?
L-phenylalanine
trans-cinnamate + NH3
show the reaction diagram
L-tryptophan
3-indoleacrylate + ammonia
show the reaction diagram
L-tyrosine
trans-p-hydroxycinnamate + NH3
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-tryptophan
3-indoleacrylate + ammonia
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00004
L-tryptophan
-
pH and temperature not specified in the publication
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterotetramer
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE