Reference on EC 4.3.1.17 - L-serine ammonia-lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Porter, P.N.; Grishaver, M.S.; Jones, O.W.
Characterization of human cystathionine beta-synthase. Evidence for the identity of human L-serine dehydratase and cystathionine beta-synthase
Biochim. Biophys. Acta
364
128-139
1974
Homo sapiens
Farias, M.E.; Strasser de Saad, A.M.; Pesce de Ruiz Holgado, A.A.; Oliver, G.
Evidence for the presence of L-serine dehydratase in Lactobacillus murinus
J. Gen. Appl. Microbiol.
31
563-567
1985
Ligilactobacillus murinus, Ligilactobacillus murinus CNRZ 313
-
Newman, E.B.; Kapoor, V.
In vitro studies on L-serine deaminase activity of Escherichia coli K12
Can. J. Biochem.
58
1292-1297
1980
Escherichia coli
Yeung, Y.G.; Yeung, D.
Comparative studies on threonine and serine dehydratases in rat liver
Int. J. Biochem.
11
161-164
1980
Rattus norvegicus
Gannon, F.; Bridgeland, E.S.; Jones, K.M.
L-Serine dehydratase from Arthrobacter globiformis
Biochem. J.
161
345-355
1977
Arthrobacter globiformis
Gannon, F.; Jones, K.M.
An activity stain for L-serine dehydratase in polyacrylamide gels
Anal. Biochem.
79
594-596
1977
Arthrobacter globiformis
Grillo, M.A.
Serine dehydratase in animal tissues
Acta Vitaminol. Enzymol.
27
51-61
1973
Gallus gallus, Rattus norvegicus
Morikawa, Y.; Nakamura, N.; Kimura, K.
Purification and some properties of L-serine dehydratase of Corynebacterium sp.
Agric. Biol. Chem.
38
531-537
1974
Corynebacterium sp.
-
Isenberg, S.; Newman, E.B.
Studies on L-serine deaminase in Escherichia coli K-12
J. Bacteriol.
118
53-58
1974
Escherichia coli
Simon, D.; Kroeger, H.
Interactions of L-serine dehydratase from rat liver with its coenzyme and substrates
Biochim. Biophys. Acta
334
208-217
1974
Rattus norvegicus
-
Simon, D.; Hoshino, J.; Kroeger, H.
L-Serine dehydratase from rat liver. Purification and some properties
Biochim. Biophys. Acta
321
361-368
1973
Rattus norvegicus
Hoshino, J.; Simon, D.; Kroeger, H.
Influence of monovalent cations on the activity of L-serine (L-threonine) dehydratase from rat liver
Eur. J. Biochem.
27
388-394
1972
Rattus norvegicus
Sagers, R.D.; Carter, J.E.
L-Serine dehydratase (Clostridium acidiurici)
Methods Enzymol.
17B
351-356
1971
Clostridium acidi-urici
-
Pestana, A.; Sandoval, I.V.; Sols, A.
Inhibition by homocysteine of serine dehydratase and other pyridoxal 5'-phosphate enzymes of the rat through cofactor blockage
Arch. Biochem. Biophys.
146
373-379
1971
Rattus norvegicus
Kubota, K.; Yokozeki, K.; Ozaki, H.
Effect of L-serine dehydratase activity onL-serine production by Corynebacterium glycinophilum and an examination of the properties of the enzyme
J. Ferment. Bioeng.
67
391-394
1989
Corynebacterium glyciniphilum, Corynebacterium glyciniphilum AJ-3170
-
Farias, M.E.; Strasser de Saad, A.M.; Pesce de Ruiz Holgado, A.A.; Oliver, G.
Purification and properties of L-serine dehydratase from Lactobacillus fermentum ATCC 14931
Curr. Microbiol.
22
205-211
1991
Limosilactobacillus fermentum
-
Grabowski, R.; Hofmeister, A.E.M.; Buckel, W.
Bacterial L-serine dehydratases: a new family of enzymes containing iron-sulfur clusters
Trends Biochem. Sci.
18
297-300
1993
Klebsiella aerogenes, Arthrobacter globiformis, Burkholderia cepacia, Clostridium acidi-urici, Escherichia coli, Limosilactobacillus fermentum, Peptoniphilus asaccharolyticus
Zinecker, H.; Andreesen, J.R.; Pich, A.
Partial purification of an iron-dependent L-serine dehydratase from Clostridium sticklandii
J. Basic Microbiol.
38
147-155
1998
Acetoanaerobium sticklandii
Hofmeister, A.E.M.; Grabowski, R.; Linder, D.; Buckel, W.
L-Serine and L-threonine dehydratase from Clostridium propionicum. Two enzymes with different prosthetic groups
Eur. J. Biochem.
215
341-349
1993
Anaerotignum propionicum
Hofmeister, A.E.M.; Albracht, S.P.J.; Buckel, W.
Iron-sulfur cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus: correlation of the cluster type with enzymatic activity
FEBS Lett.
351
416-418
1994
Peptoniphilus asaccharolyticus
Grabowski, R.; Buckel, W.
Purification and properties of an iron-sulfur containing and pyridoxal-phosphate-independent L-serine dehydratase from Peptostreptococcus asaccharolyticus
Eur. J. Biochem.
199
89-94
1991
Peptoniphilus asaccharolyticus
Su, H.; Moniakis, J.; Newman, E.B.
Use of gene fusion of the structural gene sdaA to purify L-serine deaminase 1 from Escherichia coli K-12
Eur. J. Biochem.
211
521-527
1993
Escherichia coli
Newman, E.B.; Walker, C.; Ziegler-Skylakis, K.
A possible mechanism for the in vitro activation of L-serine deaminase activity in Escherichia coli K12
Biochem. Cell Biol.
68
723-728
1990
Escherichia coli
Hopgood, M.F.; Ballard, F.J.
The relative stability of liver cytosol enzymes incubated in vitro
Biochem. J.
144
371-376
1974
Rattus norvegicus
Ramos, F.; Wiame, J.M.
Occurrence of a catabolic L-serine (L-threonine) deaminase in Saccharomyces cerevisiae
Eur. J. Biochem.
123
571-576
1982
Saccharomyces cerevisiae
Suda, M.; Nakagawa, H.
L-Serine dehydratase (rat liver)
Methods Enzymol.
17B
346-351
1971
Rattus norvegicus
-
Ogawa, H.; Takasugawa, F.; Wakaki, K.; Kishi, H.; Eskandarian, M.R.; Kobayashi, M.; Date, T.; Huh, N.H.; Pitot, H.C.
Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis
J. Biol. Chem.
274
12855-12860
1999
Rattus norvegicus
Sun, L.; Li, X.; Dong, Y.; Yang, M.; Liu, Y.; Han, X.; Zhang, X.; Pang, H.; Rao, Z.
Crystallization and preliminary crystallographic analysis of human serine dehydratase
Acta Crystallogr. Sect. D
59
2297-2299
2003
Homo sapiens
Yamada, T.; Komoto, J.; Takata, Y.; Ogawa, H.; Pitot, H.C.; Takusagawa, F.
Crystal structure of serine dehydratase from rat liver
Biochemistry
42
12854-12865
2003
Rattus norvegicus (P09367)
Imai, S.; Kanamoto, R.; Yagi, I.; Kotaru, M.; Saeki, T.; Iwami, K.
Response of the induction of rat liver serine dehydratase to changes in the dietary protein requirement
Biosci. Biotechnol. Biochem.
67
383-387
2003
Rattus norvegicus
Laroche, M.; Pukall, R.; Ulber, R.
Recovery and characterization of a L-serine dehydratase from the marine bacterium Paracoccus seriniphilus for the construction of bioanalytical systems
Chem. -Ing. -Tech.
75
146-149
2003
Paracoccus seriniphilus
-
Velayudhan, J.; Jones, M.A.; Barrow, P.A.; Kelly, D.J.
L-serine catabolism via an oxygen-labile L-serine dehydratase is essential for colonization of the avian gut by Campylobacter jejuni
Infect. Immun.
72
260-268
2004
Campylobacter jejuni
Ogawa, H.; Gomi, T.; Takusagawa, F.; Masuda, T.; Goto, T.; Kan, T.; Huh, N.H.
Evidence for a dimeric structure of rat liver serine dehydratase
Int. J. Biochem. Cell Biol.
34
533-543
2002
Ovis aries, Rattus norvegicus
Xue, H.H.; Fujie, M.; Sakaguchi, T.; Oda, T.; Ogawa, H.; Kneer, N.M.; Lardy, H.A.; Ichiyama, A.
Flux of the L-serine metabolism in rat liver. The predominant contribution of serine dehydratase
J. Biol. Chem.
274
16020-16027
1999
Rattus norvegicus
Strisovsky, K.; Jiraskova, J.; Mikulova, A.; Rulisek, L.; Konvalinka, J.
Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity
Biochemistry
44
13091-13100
2005
Mus musculus (Q9QZX7)
Strisovsky, K.; Jiraskova, J.; Barinka, C.; Majer, P.; Rojas, C.; Slusher, B.S.; Konvalinka, J.
Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate
FEBS Lett.
535
44-48
2003
Mus musculus (Q9QZX7)
Foltyn, V.N.; Bendikov, I.; De Miranda, J.; Panizzutti, R.; Dumin, E.; Shleper, M.; Li, P.; Toney, M.D.; Kartvelishvily, E.; Wolosker, H.
Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity
J. Biol. Chem.
280
1754-1763
2005
Mus musculus
Neidle, A.; Dunlop, D.S.
Allosteric regulation of mouse brain serine racemase
Neurochem. Res.
27
1719-1724
2002
Mus musculus
Nagayoshi, C.; Ishibashi, M.; Kita, Y.; Matsuoka, M.; Nishimoto, I.; Tokunaga, M.
Expression, refolding and characterization of human brain serine racemase in Escherichia coli with N-terminal His-tag
Protein Pept. Lett.
12
487-490
2005
Homo sapiens
Kanamoto, R.; Fujita, K.; Kumasaki, M.; Imai, S.; Kotaru, M.; Saeki, T.; Iwami, K.
Inverse correlation between the nitrogen balance and induction of rat liver serine dehydratase (SDH) by dietary protein
Biosci. Biotechnol. Biochem.
68
888-893
2004
Rattus norvegicus
Burman, J.D.; Harris, R.L.; Hauton, K.A.; Lawson, D.M.; Sawers, R.G.
The iron-sulfur cluster in the L-serine dehydratase TdcG from Escherichia coli is required for enzyme activity
FEBS Lett.
576
442-444
2004
Escherichia coli
Kashii, T.; Gomi, T.; Oya, T.; Ishii, Y.; Oda, H.; Maruyama, M.; Kobayashi, M.; Masuda, T.; Yamazaki, M.; Nagata, T.; Tsukada, K.; Nakajima, A.; Tatsu, K.; Mori, H.; Takusagawa, F.; Ogawa, H.; Pitot, H.C.
Some biochemical and histochemical properties of human liver serine dehydratase
Int. J. Biochem. Cell Biol.
37
574-589
2005
Rattus norvegicus, Homo sapiens (P20132), Homo sapiens
Cicchillo, R.M.; Baker, M.A.; Schnitzer, E.J.; Newman, E.B.; Krebs, C.; Booker, S.J.
Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis
J. Biol. Chem.
279
32418-32425
2004
Escherichia coli
Lopez-Flores, I.; Barroso, J.B.; Valderrama, R.; Esteban, F.J.; Martinez-Lara, E.; Luque, F.; Peinado, M.A.; Ogawa, H.; Lupianez, J.A.; Peragon, J.
Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion
Mol. Cell. Biochem.
268
33-43
2005
Rattus norvegicus
Sun, L.; Bartlam, M.; Liu, Y.; Pang, H.; Rao, Z.
Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver
Protein Sci.
14
791-798
2005
Homo sapiens
Lopez-Flores, I.; Peragon, J.; Valderrama, R.; Esteban, F.J.; Luque, F.; Peinado, M.A.; Aranda, F.; Lupianez, J.A.; Barroso, J.B.
Downregulation in the expression of the serine dehydratase in the rat liver during chronic metabolic acidosis
Am. J. Physiol.
291
R1295-R1302
2006
Rattus norvegicus
Ogawa, H.; Gomi, T.; Nishizawa, M.; Hayakawa, Y.; Endo, S.; Hayashi, K.; Ochiai, H.; Takusagawa, F.; Pitot, H.C.; Mori, H.; Sakurai, H.; Koizumi, K.; Saiki, I.; Oda, H.; Fujishita, T.; Miwa, T.; Maruyama, M.; Kobayashi, M.
Enzymatic and biochemical properties of a novel human serine dehydratase isoform
Biochim. Biophys. Acta
1764
961-971
2006
Homo sapiens (P20132), Homo sapiens
Zhong, B.; Sakai, S.; Saeki, T.; Kanamoto, R.
Excess leucine intake induces serine dehydratase in rat liver
Biosci. Biotechnol. Biochem.
71
2614-2617
2007
Rattus norvegicus (P09367)
Anfora, A.T.; Haugen, B.J.; Roesch, P.; Redford, P.; Welch, R.A.
Roles of serine accumulation and catabolism in the colonization of the murine urinary tract by Escherichia coli CFT073
Infect. Immun.
75
5298-5304
2007
Escherichia coli
Elzainy, T.A.; Hassan, M.M.; Ali, T.H.
Occurrence of L-serine (L-threonine) deaminating enzyme in filamentous fungi
J. Biol. Sci.
6
564-571
2006
Aspergillus niger, Aspergillus terreus, Aspergillus terricola, Aspergillus niger NRRL 3
-
Elzainy, T.A.; Hassan, M.M.; Ali, T.H.
Occurrence of L-serine (L-threonine) deaminating enzyme in filamentous fungi
J. Biol. Sci. (Faisalabad)
6
564-571
2006
Penicillium palitans, Penicillium palitans NRC 510
-
Yamada, T.; Komoto, J.; Kasuya, T.; Takata, Y.; Ogawa, H.; Mori, H.; Takusagawa, F.
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies
Biochim. Biophys. Acta
1780
809-818
2008
Homo sapiens (Q96GA7), Homo sapiens
Risso, C.; Van Dien, S.J.; Orloff, A.; Lovley, D.R.; Coppi, M.V.
Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens
J. Bacteriol.
190
2266-2274
2008
Geobacter sulfurreducens, Geobacter sulfurreducens DSM 12127
Zhao, Z.; Liu, H.
A quantum mechanical/molecular mechanical study on the catalysis of the pyridoxal 5'-phosphate-dependent enzyme L-serine dehydratase
J. Phys. Chem. B
112
13091-13100
2008
Rattus norvegicus (P09367)
Zhang, X.; Newman, E.
Deficiency in L-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12
Mol. Microbiol.
69
870-881
2008
Escherichia coli K-12
Husain, A.; Jeelani, G.; Sato, D.; Ali, V.; Nozaki, T.
Characterization of two isotypes of L-threonine dehydratase from Entamoeba histolytica
Mol. Biochem. Parasitol.
170
100-104
2010
Entamoeba histolytica (B1N2N4), Entamoeba histolytica
Xu, X.L.; Chen, S.; Grant, G.A.
Kinetic, mutagenic, and structural homology analysis of L-serine dehydratase from Legionella pneumophila
Arch. Biochem. Biophys.
515
28-36
2011
Legionella pneumophila (Q5ZXE1), Legionella pneumophila
Zhang, X.; El-Hajj, Z.W.; Newman, E.
Deficiency in L-serine deaminase interferes with one-carbon metabolism and cell wall synthesis in Escherichia coli K-12
J. Bacteriol.
192
5515-5525
2010
Escherichia coli (P16095), Escherichia coli (P30744), Escherichia coli (P42630), Escherichia coli
Wang, C.Y.; Ku, S.C.; Lee, C.C.; Wang, A.H.
Modulating the function of human serine racemase and human serine dehydratase by protein engineering
Protein Eng. Des. Sel.
25
741-749
2012
Homo sapiens (P20132), Homo sapiens
Chen, S.; Xu, X.L.; Grant, G.A.
Allosteric activation and contrasting properties of L-serine dehydratase types 1 and 2
Biochemistry
51
5320-5328
2012
Bacillus subtilis, Legionella pneumophila (Q5ZXE1), Legionella pneumophila
Grant, G.A.
Kinetic evidence of a noncatalytic substrate binding site that regulates activity in Legionella pneumophila L-serine dehydratase
Biochemistry
51
6961-6967
2012
Legionella pneumophila
Rybniker, J.; Krumbach, K.; van Gumpel, E.; Plum, G.; Eggeling, L.; Hartmann, P.
The cytotoxic early protein 77 of mycobacteriophage L5 interacts with MSMEG_3532, an L-serine dehydratase of Mycobacterium smegmatis
J. Basic Microbiol.
51
515-522
2011
Mycolicibacterium smegmatis (A0QY48), Mycolicibacterium smegmatis
Qin, Z.; Yan, Q.; Ma, Q.; Jiang, Z.
Crystal structure and characterization of a novel L-serine ammonia-lyase from Rhizomucor miehei
Biochem. Biophys. Res. Commun.
466
431-437
2015
Rhizomucor miehei (A0A0X1KHE6), Rhizomucor miehei, Rhizomucor miehei CAU432 (A0A0X1KHE6)
Fujino, A.; Ose, T.; Yao, M.; Tokiwano, T.; Honma, M.; Watanabe, N.; Tanaka, I.
Structural and enzymatic properties of 1-aminocyclopropane-1-carboxylate deaminase homologue from Pyrococcus horikoshii
J. Mol. Biol.
341
999-1013
2004
Pyrococcus horikoshii (O57809)
Xu, X.L.; Grant, G.A.
Mutagenic and chemical analyses provide new insight into enzyme activation and mechanism of the type 2 iron-sulfur L-serine dehydratase from Legionella pneumophila
Arch. Biochem. Biophys.
596
108-117
2016
Legionella pneumophila (Q5ZXE1), Legionella pneumophila
Yan, Y.; Grant, G.A.; Gross, M.L.
Hydrogen-deuterium exchange mass spectrometry reveals unique conformational and chemical transformations occurring upon [4Fe-4S] cluster binding in the type 2 L-serine dehydratase from Legionella pneumophila
Biochemistry
54
5322-5328
2015
Legionella pneumophila (Q5ZXE1), Legionella pneumophila
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