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IUBMB CommentsHydroxylamine can replace ammonia as a substrate. Crotonoyl-pantetheine can replace crotonoyl-CoA but it is a poorer substrate.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
3-aminobutyryl-coa ammonia lyase,
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3-aminobutyryl-CoA ammonia lyase
Anaerobic bacteria
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Ammonia lyase, L-3-aminobutyryl coenzyme A
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Kal
Anaerobic bacteria
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L-3-Aminobutyryl coenzyme A deaminase
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L-3-Aminobutyryl-CoA deaminase
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L-3-aminobutyryl-CoA = crotonoyl-CoA + NH3
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Double-bond formation
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Deamination
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Deamination
Anaerobic bacteria
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L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)
Hydroxylamine can replace ammonia as a substrate. Crotonoyl-pantetheine can replace crotonoyl-CoA but it is a poorer substrate.
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crotonoyl-CoA + NH3
L-3-aminobutyryl-CoA
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NH3 in form of NH4Cl
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Crotonyl pantetheine + NH3
Aminobutanoylpantetheine
Crotonyl-CoA + hydroxylamine
CoA + 3-methyl-5-isoxazolidinone
L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
L-3-aminobutyryl-CoA
crotonoyl-CoA + NH3
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additional information
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Crotonyl pantetheine + NH3
Aminobutanoylpantetheine
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aminated 100% as fast as crotonyl-CoA
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Crotonyl pantetheine + NH3
Aminobutanoylpantetheine
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aminated 100% as fast as crotonyl-CoA
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Crotonyl-CoA + hydroxylamine
CoA + 3-methyl-5-isoxazolidinone
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Crotonyl-CoA + hydroxylamine
CoA + 3-methyl-5-isoxazolidinone
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
Anaerobic bacteria
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
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only active with the L-isomer
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
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only active with the L-isomer
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L-3-Aminobutanoyl-CoA
Crotonyl-CoA + NH3
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additional information
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enzyme is induced by growth on 3,5-diaminohexanoate
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additional information
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enzyme is induced by growth on 3,5-diaminohexanoate
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additional information
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enzyme is involved in the pathway of Lys degradation
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additional information
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enzyme is involved in the pathway of Lys degradation
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additional information
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enzyme is involved in the pathway of Lys degradation
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additional information
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additional information
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enzyme is induced by growth on 3,5-diaminohexanoate
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additional information
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enzyme is induced by growth on 3,5-diaminohexanoate
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additional information
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enzyme is involved in the pathway of Lys degradation
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additional information
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enzyme is involved in the pathway of Lys degradation
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additional information
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enzyme is involved in the pathway of Lys degradation
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6,6'-Dithiodinicotinic acid
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CaCl2
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2 mM, 28% inhibition
iodoacetamide
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crotonyl-CoA protects
KCl
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400 mM, 32% inhibition
MgCl2
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2 mM, 22% inhibition
MgSO4
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2 mM, 22% inhibition
NaCl
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400 mM, 34% inhibition
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0.03
L-3-aminobutyryl-CoA
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0.07
NH3
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with crotonyl-CoA as cosubstrate
0.045
crotonyl-CoA
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crotonyl-CoA
Anaerobic bacteria
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Anaerobic bacteria
environmental sample obtained from anaerobic digesters, putative lysine-fermenting bacteria like Fusobacterium nucleatum subsp. nucleatum, Fusobacterium nucleatum subsp. vincentii, Thermoanaerobacter tengcongensis, Porphyromonas gingivalis, Alkaliphilus metalliredigenes, Myxococcus xanthus, Anaeromyxobacter dehlogenans, Clostridium sp., Rhodoferax ferrireducens, Symbiobacterium thermophilum, Nocarioides, Janibacter sp.
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brenda
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brenda
SB4
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brenda
SB4
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brenda
ATCC 25586
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brenda
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17000
Anaerobic bacteria
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SDS-PAGE
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pH 6.8, half-life: 7.5 h, 0.05 mg of protein per ml
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-20°C, 3 mg/ml enzyme concentration, 4% loss of activity in 3 months
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of the recombinant proteins by HiPrep 26/10 desalting column chromatography
Anaerobic bacteria
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in Escherichia coli
Anaerobic bacteria
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biotechnology
Anaerobic bacteria
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lysine fermentation pathway
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Barker, H.A.; Kahn, J.M.; Hedrick, L.
Pathway of lysine degradation in Fusobacterium nucleatum
J. Bacteriol.
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201-207
1982
Fusobacterium nucleatum
brenda
Barker, H.A.; Kahn, J.M.; Chew, S.
Enzymes involved in 3,5-diaminohexanoate degradation by Brevibacterium sp.
J. Bacteriol.
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1165-1170
1980
Brevibacterium sp.
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Jeng, I.M.; Barker, H.A.
Purification and properties of L-3-aminobutyryl coenzyme A deaminase from a lysine-fermenting Clostridium
J. Biol. Chem.
249
6578-6584
1974
Clostridium sp., Clostridium sp. SB4
brenda
Kreimeyer, A.; Perret, A.; Lechaplais, C.; Vallenet, D.; Medigue, C.; Salanoubat, M.; Weissenbach, J.
Identification of the last unknown genes in the fermentation pathway of lysine
J. Biol. Chem.
282
7191-7197
2007
Anaerobic bacteria
brenda
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