Reference on EC 4.2.99.B1 - DNA 5'-deoxyribose phosphate lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Prasad, R.; Batra, V.K.; Yang, X.P.; Krahn, J.M.; Pedersen, L.C.; Beard, W.A.; Wilson, S.H.
Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism
DNA Repair
4
1347-1357
2005
Homo sapiens (P06746)
Alonso, A.; Terrados, G.; Picher, A.J.; Giraldo, R.; Blanco, L.; Larraga, V.
An intrinsic 5'-deoxyribose-5-phosphate lyase activity in DNA polymerase beta from Leishmania infantum supports a role in DNA repair
DNA repair
5
89-101
2006
Leishmania infantum (Q9U6N3), Leishmania infantum
Gellon, L.; Carson, D.R.; Carson, J.P.; Demple, B.
Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair
DNA Repair
7
187-198
2008
Saccharomyces cerevisiae (P53632), Saccharomyces cerevisiae
Lopes, D.d.O.; Schamber-Reis, B.L.F.; Regis-da-Silva, C.G.; Rajao, M.A.; DaRocha, W.D.; Macedo, A.M.; Franco, G.R.; Nardelli, S.C.; Schenkman, S.; Hoffmann, J.-S.; Cazaux, C.; Pena, S.D.J.; Teixeira, S.M.R.; Machado, C.R.
Biochemical studies with DNA polymerase beta and DNA polymerase beta -PAK of Trypanosoma cruzi suggest the involvement of these proteins in mitochondrial DNA maintenance
DNA Repair
7
1882-1892
2008
Trypanosoma cruzi
Allinson, S.L.; Dianova, II; Dianov, G.L.
DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts
EMBO J.
20
6919-6926
2001
Homo sapiens
Grin, I.R.; Khodyreva, S.N.; Nevinsky, G.A.; Zharkov, D.O.
Deoxyribophosphate lyase activity of mammalian endonuclease VIII-like proteins
FEBS Lett.
580
4916-4922
2006
Mus musculus
Prasad, R.; Beard, W.A.; Chyan, J.Y.; Maciejewski, M.W.; Mullen, G.P.; Wilson, S.H.
Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities
J. Biol. Chem.
273
11121-11126
1998
Homo sapiens (P06746)
Prasad, R.; Beard, W.A.; Strauss, P.R.; Wilson, S.H.
Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism
J. Biol. Chem.
273
15263-15270
1998
Homo sapiens
Garcia-Diaz, M.; Bebenek, K.; Kunkel, T.A.; Blanco, L.
Identification of an intrinsic 5'-deoxyribose-5-phosphate lyase activity in human DNA polynmerase lambda. A possible role in base excision repair
J. Biol. Chem.
276
34659-34663
2001
Homo sapiens (Q9UGP5), Homo sapiens
Saxowsky, T.T.; Matsumoto, Y.; Englund, P.T.
The mitochondrial DNA polymerase beta from Crithdia fasciculata has a 5'-deoxyribose phosphate (dRP) lyase activity but is deficient in the release of dRP
J. Biol. Chem.
277
37201-37206
2002
Crithidia fasciculata
Wong, D.; Demple, B.
Modulation of the 5'-deoxyribose-5-phosphate lyase and DNA synthesis activities of mammalian DNA polymerase beta by apurinic/apyrimidinic endonuclease 1
J. Biol. Chem.
279
25268-25275
2004
Homo sapiens
Maciejewski, M.W.; Liu, D.; Prasad, R.; Wilson, S.H.; Mullen, G.P.
Backbone dynamics and refined solution structure of the N-terminal domain of DNA polymerase beta. Correlation with DNA binding and dRP lyase activity
J. Mol. Biol.
296
229-253
2000
Rattus norvegicus
Sobol, R.W.; Prasad, R.; Evenski, A.; Baker, A.; Yang, X.P.; Horton, J.K.; Wilson, S.H.
The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity
Nature
405
807-810
2000
Mus musculus
Prasad, R.; Longley, M.J.; Sharief, F.S.; Hou, E.W.; Copeland, W.C.; Wilson, S.H.
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro
Nucleic Acids Res.
37
1868-1877
2009
Homo sapiens
Bogani, F.; Boehmer, P.E.
The replicative DNA polymerase of herpes simplex virus 1 exhibits apurinic/apyrimidinic and 5-deoxyribose phosphate lyase activities
Proc. Natl. Acad. Sci. USA
105
11709-11714
2008
Human alphaherpesvirus 1
Longley, M.J.; Prasad, R.; Srivastava, D.K.; Wilson, S.H.; Copeland, W.C.
identification of 5'-deoxyribose phosphate lyase activity in human DNA polymerase gamma and its role in mitochondrial base excision repair in vitro
Proc. Natl. Acad. Sci. USA
95
12244-12248
1998
Homo sapiens
Bebenek, K.; Tissier, A.; Frank, E.G.; McDonald, J.P.; Prasad, R.; Wilson, S.H.; Woodgate, R.; Kunkel, T.A.
5'-Deoxyribose phosphate lyase activity of human DNA polymerase iota in vitro
Science
291
2156-2159
2001
Homo sapiens
Roberts, S.A.; Strande, N.; Burkhalter, M.D.; Strom, C.; Havener, J.M.; Hasty, P.; Ramsden, D.A.
Ku is a 5-dRP/AP lyase that excises nucleotide damage near broken ends
Nature
464
1214-1217
2010
Mus musculus
Caglayan, M.; Batra, V.K.; Sassa, A.; Prasad, R.; Wilson, S.H.
Role of polymerase beta in complementing aprataxin deficiency during abasic-site base excision repair
Nat. Struct. Mol. Biol.
21
497-499
2014
Homo sapiens (P06746)
Daskalova, S.M.; Bhattacharya, C.; Dedkova, L.M.; Hecht, S.M.
Probing the flexibility of the catalytic nucleophile in the lyase catalytic pocket of human DNA polymerase beta with unnatural lysine analogues
Biochemistry
56
500-513
2017
Homo sapiens (P06746)
Daskalova, S.M.; Bai, X.; Hecht, S.M.
Study of the lyase activity of human DNA polymerase beta using analogues of the intermediate Schiff base complex
Biochemistry
57
2711-2722
2018
Homo sapiens (P06746)
Quinones, J.L.; Demple, B.
When DNA repair goes wrong BER-generated DNA-protein crosslinks to oxidative lesions
DNA Repair
44
103-109
2016
Homo sapiens (P06746)
Trasvina-Arenas, C.H.; Baruch-Torres, N.; Cordoba-Andrade, F.J.; Ayala-Garcia, V.M.; Garcia-Medel, P.L.; Diaz-Quezada, C.; Peralta-Castro, A.; Ordaz-Ortiz, J.J.; Brieba, L.G.
Identification of a unique insertion in plant organellar DNA polymerases responsible for 5'-dRP lyase and strand-displacement activities implications for base excision repair
DNA Repair
65
1-10
2018
Arabidopsis thaliana (F4I6M1), Arabidopsis thaliana (Q84ND9), Arabidopsis thaliana
Yamamoto, R.; Umetsu, M.; Yamamoto, M.; Matsuyama, S.; Takenaka, S.; Ide, H.; Kubo, K.
AP endonuclease knockdown enhances methyl methanesulfonate hypersensitivity of DNA polymerase beta knockout mouse embryonic fibroblasts
J. Radiat. Res.
56
462-466
2015
Homo sapiens (P06746), Mus musculus (Q8K409)
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