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Disease on EC 4.2.99.B1 - DNA 5'-deoxyribose phosphate lyase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aberrant Crypt Foci
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase {beta} haploinsufficient mice.
Adenocarcinoma
DNA polymerase beta expression differences in selected human tumors and cell lines.
Adenoma
Genetic variation in the base excision repair pathway, environmental risk factors, and colorectal adenoma risk.
Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3.
Rapid recognition of aberrant dHPLC elution profiles using the Transgenomic Navigator software.
Brain Neoplasms
Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea.
Breast Neoplasms
Comprehensive Profiling of DNA Repair Defects in Breast Cancer Identifies a Novel Class of Endocrine Therapy Resistance Drivers.
DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2.
Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.
Burkitt Lymphoma
Detection of genomic aberrations in molecularly defined Burkitt lymphoma by array-based high resolution single nucleotide polymorphism analysis.
Carcinogenesis
Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker.
DNA polymerase beta expression differences in selected human tumors and cell lines.
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase {beta} haploinsufficient mice.
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Carcinoma
Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker.
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Overexpression of DNA polymerase iota (Pol?) in esophageal squamous cell carcinoma.
Carcinoma, Hepatocellular
Hepatitis C virus induces oxidative stress, DNA damage and modulates the DNA repair enzyme NEIL1.
Polymorphisms of base-excision repair genes and the hepatocarcinogenesis.
Carcinoma, Squamous Cell
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Cataract
A variant in a microRNA binding site in NEIL2 3'UTR confers susceptibility to age-related cataracts.
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.
Cockayne Syndrome
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity.
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Colonic Neoplasms
DNA polymerase beta expression differences in selected human tumors and cell lines.
Colorectal Neoplasms
Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.
Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
Cryptorchidism
Effect of busulphan treatment and elevated temperature on the expression of the beta-pol gene in rat testis.
dna 5'-deoxyribose phosphate lyase deficiency
Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.
The deoxyribose phosphate lyase of DNA polymerase ? suppresses a processive DNA synthesis to prevent trinucleotide repeat instability.
Glioma
Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea.
Hepatitis C
Polymorphisms of base-excision repair genes and the hepatocarcinogenesis.
Herpes Simplex
The replicative DNA polymerase of herpes simplex virus 1 exhibits apurinic/apyrimidinic and 5'-deoxyribose phosphate lyase activities.
Hypersensitivity
Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses.
Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage.
Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions.
Identification of small molecule synthetic inhibitors of DNA polymerase beta by NMR chemical shift mapping.
Mammalian DNA beta-polymerase in base excision repair of alkylation damage.
The lyase activity of the DNA repair protein beta-polymerase protects from DNA-damage-induced cytotoxicity.
Infections
Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells.
Roles of conserved residues within the pre-NH2-terminal domain of herpes simplex virus 1 DNA polymerase in replication and latency in mice.
The DNA Glycosylase NEIL2 Suppresses Fusobacterium-Infection-Induced Inflammation and DNA Damage in Colonic Epithelial Cells.
The HIV-1 transactivator protein Tat is a potent inducer of the human DNA repair enzyme beta-polymerase.
Lung Neoplasms
Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.
NEIL2 Protects against Oxidative DNA Damage Induced by Sidestream Smoke in Human Cells.
Lymphoma
The HIV-1 transactivator protein Tat is a potent inducer of the human DNA repair enzyme beta-polymerase.
Lymphoma, AIDS-Related
The HIV-1 transactivator protein Tat is a potent inducer of the human DNA repair enzyme beta-polymerase.
Nasopharyngeal Carcinoma
Salinomycin enhances radiotherapy sensitivity and reduces expressions of BIRC5 and NEIL2 in nasopharyngeal carcinoma.
Neoplasms
Abnormal Expressions of DNA Glycosylase Genes NEIL1, NEIL2, and NEIL3 Are Associated with Somatic Mutation Loads in Human Cancer.
Alternative splicing of DNA polymerase beta mRNA is not tumor-specific.
Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker.
DNA polymerase beta expression differences in selected human tumors and cell lines.
DNA polymerases during tumor growth.
Elevated expression of DNA polymerase beta gene in glioma cell lines with acquired resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea.
Folate deficiency provides protection against colon carcinogenesis in DNA polymerase {beta} haploinsufficient mice.
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.
Genomic landscape of DNA repair genes in cancer.
Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate.
Identification of novel mRNA isoforms for human DNA polymerase beta.
PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2.
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice.
Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer.
Transcriptional upregulation of DNA polymerase beta by TEIF.
Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments.
Viral integration in BK polyomavirus-associated urothelial carcinoma in renal transplant recipients: multistage carcinogenesis revealed by next-generation virome capture sequencing.
Neuroblastoma
Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases.
Oropharyngeal Neoplasms
Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx.
Ovarian Neoplasms
DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Prion Diseases
DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease.
Rectal Neoplasms
REG4, NEIL2, and BIRC5 gene expression correlates with gamma-radiation sensitivity in patients with rectal cancer receiving radiotherapy.
Stomach Neoplasms
Genetic Variation of BCL2 (rs2279115), NEIL2 (rs804270), LTA (rs909253), PSCA (rs2294008) and PLCE1 (rs3765524, rs10509670) Genes and Their Correlation to Gastric Cancer Risk Based on Universal Tagged Arrays and Fe3O4 Magnetic Nanoparticles.
Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).