Reference on EC 4.2.99.18 - DNA-(apurinic or apyrimidinic site) lyase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nakabeppu, Y.; Sekiguchi, M.
Physical association of pyrimidine dimer DNA glycosylase and apurinic/apyrimidinic DNA endonuclease essential for repair of ultraviolet-damaged DNA
Proc. Natl. Acad. Sci. USA
78
2742-2746
1981
Tequatrovirus T4, Escherichia coli
Bailly, V.; Sente, B.; Verly, W.G.
Bacteriophage-T4 and Micrococcus luteus UV endonucleases are not endonucleases but beta-elimination and sometimes betadelta-elimination catalysts
Biochem. J.
259
751-759
1989
Tequatrovirus T4, Micrococcus luteus
Kim, J.; Linn, S.
The mechanism of action of E. coli endonuclease III and T4 UV endonuclease (endonuclease V) at AP sites
Nucleic Acids Res.
16
1135-1141
1988
Tequatrovirus T4, Escherichia coli
Grafstrom, R.H.; Park, L.; Grossman, L.
Enzymatic repair of pyrimidine dimer-containing DNA. A 5' dimer DNA glycosylase: 3'-apyrimidinic endonuclease mechanism from Micrococcus luteus
J. Biol. Chem.
257
13465-13474
1982
Bacillus subtilis
Whisstock, J.C.; Romero, S.; Gurung, R.; Nandurkar, H.; Ooms, L.M.; Bottomley, S.P.; Mitchell, C.A.
The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis
J. Biol. Chem.
275
37055-37061
2000
Mammalia
Hatahet, Z.; Kow, Y.W.; Purmal, A.A.; Cunningham, R.P.; Wallace, S.S.
New substrates for old enzymes. 5-Hydroxy-2'-deoxycytidine and 5-hydroxy-2'-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2'-deoxyuridine is a substrate for uracil DNA N-glycosylase
J. Biol. Chem.
269
18814-18820
1994
Escherichia coli
Thibodeau, L.; Bricteux, S.; Verly, W.G.
Purification and properties of the major apurinic/apyrimidinic endodeoxyribonuclease of rat-liver chromatin
Eur. J. Biochem.
110
379-385
1980
Rattus norvegicus
Thibodeau, L.; Verly, W.G.
Cellular localization of the apurinic/apyrimidinic endodeoxyribonucleases in rat liver
Eur. J. Biochem.
107
555-563
1980
Rattus norvegicus
Ivanov, V.A.; Tretyak, T.M.; Afonin, Y.N.
Excision of apurinic and/or apyrimidinic sites from DNA by nucleolytical enzymes from rat brain
Eur. J. Biochem.
172
155-159
1988
Rattus norvegicus
Verly, W.G.; Colson, P.; Zocchi, G.; Goffin, C.; Liuzzi, M.; Buchsenschmidt, G.; Muller, M.
Localization of the phosphoester bond hydrolyzed by the major apurinic/apyrmidinic endodeoxyribonuclease from rat-liver chromatin
Eur. J. Biochem.
118
195-201
1981
Rattus norvegicus
Brictreux-Gregoire, S.; Habraken, Y.; Verly, W.G.
The apurinic/apyrimidinic endodeoxyribonuclease of rat-liver chromatin
Eur. J. Biochem.
129
509-517
1983
Rattus norvegicus
Foury, F.
Endonucleases in yeast mitochondria: apurinic and manganese-stimulated deoxyribonuclease activities in the inner mitochondrial membrane of Saccharomyces cerevisiae.
Eur. J. Biochem.
124
253-259
1982
Saccharomyces cerevisiae, Saccharomyces cerevisiae D273-10B/A1
Talpaert-Borle, M.; Liuzzi, M.
Base-excision repair in carrot cells. Partial purification and characterization of uracil-DNA glycosylase and apurinic/apyrimidinic endodeoxyribonuclease
Eur. J. Biochem.
124
435-440
1982
Daucus carota
Sako, Y.; Uchida, A.; Kadota, H.
Apurinic/apyrimidinic endodeoxyribonuclease level during the life cycle of Bacillus subtilis
Agric. Biol. Chem.
45
337-339
1981
Bacillus subtilis
-
Thibodeau, L.; Verly, W.G.
Purification and properties of a plant endonuclease specific for apurinic sites
J. Biol. Chem.
252
3304-3309
1977
Phaseolus coccineus
Tomkinson, A.E.; Bonk, R.T.; Linn, S.
Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells
J. Biol. Chem.
263
12532-12537
1988
Mus musculus
Takeshita, M.; Chang, C.N.; Johnson, F.; Will, S.; Grollman, A.P.
Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases
J. Biol. Chem.
262
10171-10179
1982
Escherichia coli
Sako, Y.; Uchida, A.; Kadota, H.
Isolation and characterization of an apurinic endodeoxyribonuclease from the anaerobic thermophile Desulfotomaculum nigrificans
J. Gen. Microbiol.
130
1525-1534
1984
Desulfotomaculum nigrificans
-
Bailly, V.; Verly, W.G.
Escherichia coli endonuclease III is not an endonuclease but a beta-elimination catalyst
Biochem. J.
242
565-572
1987
Escherichia coli
Manoharan, M.; Mazumder, A.; Ranson, S.C.; Gerlt, J.A.; Bolton, P.H.
Mechanism of UV endonuclease V cleavage of abasic sites in DNA determined by 13C labeling
J. Am. Chem. Soc.
110
2690-2691
1988
Tequatrovirus T4, Escherichia coli
-
Bailly, V.; Verly, W.G.
AP endonuleases an AP lyases
Nucleic Acids Res.
17
3617-3618
1989
Escherichia coli
Gossard, F.; Verly, W.G.
Properties of the main endonucleases specific for apurinic sites of Escherichia coli (endonuclease VI)
Eur. J. Biochem.
82
321-332
1978
Escherichia coli
Sachulova, J.; Satava, J.; Veleminsky, J.
A barley endonuclease specific for apurinic DNA. Isolation and partial characterization
Eur. J. Biochem.
87
215-220
1978
Hordeum vulgare
Nes, I.F.
Purification and properties of a mouse-cell DNA-repair endonuclease which recognizes lesions in DNA induced byy ultraviolet light, depurination, gamma-rays and OsO4 treatment
Eur. J. Biochem.
112
161-168
1980
Mus musculus
Bibor, V.; Verly, W.G.
Purification and properties of endonuclease specific for apurinic sites of Bacillus stearothermophilus
J. Biol. Chem.
253
850-855
1978
Geobacillus stearothermophilus
Inoue, T.; Kada, T.
Purification and properties of a Bacillus subtilis endonuclease specific for apurinic sites in DNA
J. Biol. Chem.
253
8559-8563
1978
Bacillus subtilis
Shaper, N.L.; Grafstrom, R.H.; Grossman, L.
Human placental apurinic/apyrimidinic endonuclease. Its isolation and characterization
J. Biol. Chem.
257
13455-13458
1982
Homo sapiens
Katcher, H.L.; Wallace, S.S.
Characterization of Escherichia coli x-ray endonuclease, endonulease II
Biochemistry
22
4071-4081
1983
Escherichia coli
Brent, T.P.
Properties of a human lymphoblast AP-endonuclease asociated with activity for DAN damaged by ultraviolet light, gamma-rays, or osmium tetroxide
Biochemistry
22
4507-4512
1983
Homo sapiens
Armel, P.R.; Wallace, S.S.
DNA repair in Saccharomyces, purification and characterization of apurinic endonuleases
J. Bacteriol.
160
895-902
1984
Saccharomyces cerevisiae
Spiering, A.L.; Deutsch, W.A.
Drosophila apurinic/apyrimidinic DNA endonucleases. Characterization of mechanism of action and demonstration of a novel type of enzyme activation
J. Biol. Chem.
261
3222-3228
1986
Drosophila melanogaster
Robson, C.N.; Hickson, I.D.
Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants
Nucleic Acids Res.
19
5519-5523
1991
Homo sapiens (P27695), Homo sapiens
Demple, B.; Herman, T.; Chen, D.S.
Cloning and expression of APE, the cDNA encoding the major human apurinic exonuclease: definition of a family of DNA repair enzymes
Proc. Natl. Acad. Sci. USA
88
11450-11454
1991
Homo sapiens (P27695), Homo sapiens
Cheng, X.; Bunville, J.; Patterson, T.A.
Nucleotide sequence of cDNA for a apurinic/apyrimidinic endonuclease from HeLa cells
Nucleic Acids Res.
20
370
1992
Homo sapiens (P27695)
Sako, Y.; Uchida, A.; Kadota, H.
Isolation Isolation and characterization of a magnesium-deoendebt apurinic sites specific endodeoxyribonuclease from BAcillus subtilis
Agric. Biol. Chem.
44
567-574
1980
Bacillus subtilis
-
Frost, B.F.; Small, G.D.
Partial purification and characterization of the major endonuclease from Chlamydomonas reinhardtii
Biochim. Biophys. Acta
782
170-176
1984
Chlamydomonas reinhardtii
Nes, I.F.
Purification and characterization of an endonuclease specific for sites in DNA from a permanently established mouse palsmocytoma cell line
Nucleic Acids Res.
8
1575-1589
1980
Mus musculus
Henner, W.D.; Kiker, N.P.; Jorgensen, T.J.; Munck, J.N.
Purification and amino-terminal amino acid sequence of an apurinic/apyrimidinic endonuclease from calf thymus
Nucleic Acids Res.
15
5529-5544
1987
Bos taurus
Doetsch, P.W.; Helland, D.E.; Haseltine, W.A.
Mechanism of action of a mammalian DNA repair endonuclease
Biochemistry
25
2212-2220
1986
Bos taurus
Kow, Y.W.; Wallace, S.S.
Mechanismm of action of Escherichia coli endonuclease III
Biochemistry
26
8200-8206
1987
Escherichia coli
Asahara, H.; Wistort, P.M.; Bank, J.F.; Bakerian, R.H.; Cunningham, R.P.
Purification and characterization of Escherichia coli endonuclease III from the cloned m gene
Biochemistry
28
4444-4449
1989
Escherichia coli
Cunningham, R.P.; Asahara, H.; Bank, J.F.; Scholes, C.P.; Salerno, J.C.; Surerus, K.; Mnck, E.; McCracken, J.; Peisach, J.; Emptage, M.H.
Endonuclease is an iron-sulfur protein
Biochemistry
28
4450-4455
1989
Escherichia coli
Dizdaroglu, M.; Laval, J.; Boiteux, S.
Substrate specificity of the Escherichia coli endonuclease III: Excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals
Biochemistry
32
12105-12111
1993
Escherichia coli
Fu, W.; O'Handley, S.; Cunningham, R.P.; Johnson, M.K.
The role of the iron-sulfur cluster in Escherichia cloli endonuclease III. A resonance Raman strudy
J. Biol. Chem.
267
16135-16137
1992
Escherichia coli
Kuo, C.F.; McRee, D.E.; Cunningham, R.P.; Tainer, J.A.
Crystallization and crystallographic characterization of the iron-sulfur-containing DNA-repair enzyme endonuclease III form Escherichia coli
J. Mol. Biol.
227
347-351
1992
Escherichia coli
Helland, D.E.; Doetsch, P.W.; Haseltine, W.A.
Substrate specificity of a mammalian DNA repair endonuclease that recognizes oxidative base damage
Mol. Cell. Biol.
6
1983-1990
1986
Bos taurus
Warner, H.R.; Persson, M.L.; Bensen, R.J.; Mosbaugh, D.W.; Linn, S.
Selective inhibition by harmane of apurinic/apyrimidinic endonuclease activity of phage T4-induced UV endonuclease
Nucleic Acids Res.
9
6083-6092
1981
Escherichia coli, Homo sapiens, Tequatrovirus T4
Kim, Y.S.; Oh, S.H.
Purification and some properties of apurinic/apyrimidinic DNA endonucleases in rat liver
Int. J. Biochem.
25
1925-1933
1993
Rattus norvegicus
Malvy, C.; Pierre, J.; Lefrancois, M.; Markovits, J.; Garbay, C.; Roques, B.
Low concentrations of acridine dimers ihibit Microsoccus AP endonuclease through interaction with apurinic sites in DNA
Chem. Biol. Interact.
73
249-260
1990
Micrococcus luteus
Grafstrom, R.H.; Shaper, N.L.; Grossman, L.
Human placental apurinic/apyrimidinic endonuclease. Mechanism of action
J. Biol. Chem.
257
13459-13464
1982
Homo sapiens
Aburatani, H.; Hippo, Y.; Ishida, T.; Takashima, R.; Matsuba, C.; Kodama, T.; Takao, M.; Yasui, A.; Yamamoto, K.; Asano, M.
Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue
Cancer Res.
57
2151-2156
1997
Homo sapiens (O15527)
Beloglazova, N.G.; Petruseva, I.O.; Bulychev, N.V.; Maksakova, G.A.; Johnson, F.; Nevinskii, G.A.
Isolation and substrate specificity of apurinic/apyrimidinic endonuclease from human placenta
Mol. Biol.
31
946-951
1997
Homo sapiens
Chaudhry, M.A.; Weinfeld, M.
Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA
J. Biol. Chem.
272
15650-15655
1997
Escherichia coli, Homo sapiens
Chaudhry, M.A.; Weinfeld, M.
The action of Escherichia coli endonuclease III on multiply damaged sites in DNA
J. Mol. Biol.
249
914-922
1995
Escherichia coli
Eide, L.; Luna, L.; Gustad, E.C.; Henderson, P.T.; Essigmann, J.M.; Demple, B.; Seeberg, E.
Human endonuclease III acts preferentially on DNA damage opposite guanine residues in DNA
Biochemistry
40
6653-6659
2001
Homo sapiens
Grosch, S.; Kaina, B.
Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB
Biochem. Biophys. Res. Commun.
261
859-863
1999
Homo sapiens
Hahn, K.; Faustoferri, R.C.; Quivey, R.G., Jr.
Induction of an AP endonuclease activity in Streptococcus mutans during growth at low pH
Mol. Microbiol.
31
1489-1498
1999
Streptococcus mutans, Streptococcus mutans UA159
Hilbert, T.P.; Chaung, W.; Boorstein, R.J.; Cunningham, R.P.; Teebor, G.W.
Cloning and expression of the cDNA encoding the human homolog of the DNA repair enzyme, Escherichia coli endonuclease III
J. Biol. Chem.
272
6733-6740
1997
Homo sapiens (P78549), Homo sapiens
Ikeda, S.; Biswas, T.; Roy, R.; Izumi, T.; Boldogh, I.; Kurosky, A.; Sarker, A.H.; Seki, S.; Mitra, S.
Purification and characterization of human NTH1, a homolog of Escherichia coli endonuclease III. Direct identification of Lys-212 as the active nucleophilic residue
J. Biol. Chem.
273
21585-21593
1998
Homo sapiens (P78549), Homo sapiens
Ishchenko, A.A.; Sanz, G.; Privezentzev, C.V.; Maksimenko, A.V.; Saparbaev, M.
Characterisation of new substrate specificities of Escherichia coli and Saccharomyces cerevisiae AP endonucleases
Nucleic Acids Res.
31
6344-6353
2003
Saccharomyces cerevisiae, Escherichia coli
Lebedeva, N.A.; Khodyreva, S.N.; Favre, A.; Lavrik, O.I.
AP endonuclease 1 has no biologically significant 3'->5'-exonuclease activity
Biochem. Biophys. Res. Commun.
300
182-187
2002
Homo sapiens
Lucas, J.A.; Masuda, Y.; Bennett, R.A.O.; Strauss, N.S.; Strauss, P.R.
Single-turnover analysis of mutant human apurinic/apyrimidinic endonuclease
Biochemistry
38
4958-4964
1999
Homo sapiens
Marenstein, D.R.; Chan, M.K.; Altamirano, A.; Basu, A.K.; Boorstein, R.J.; Cunningham, R.P.; Teebor, G.W.
Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity
J. Biol. Chem.
278
9005-9012
2003
Homo sapiens
Meadows, K.L.; Song, B.; Doetsch, P.W.
Characterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function
Nucleic Acids Res.
31
5560-5567
2003
Saccharomyces cerevisiae
Mguyen, L.H.; Barsky, D.; Erzberger, J.P.; Wilson, D.M., 3rd
Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease
J. Mol. Biol.
298
447-459
2000
Homo sapiens
Micolas, E.; Beggs, J.M.; Haltiwanger, B.M.; Taraschi, T.F.
A new class of DNA glycosylase/apurinic/apyrimidinic lyases that act on specific adenines in single-stranded DNA
J. Biol. Chem.
273
17216-17220
1998
Homo sapiens
Pope, M.A.; Porello, S.L.; David, S.S.
Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G:A substrates
J. Biol. Chem.
277
22605-22615
2002
Escherichia coli, Homo sapiens
Purmal, A.A.; Rabow, L.E.; Lampman, G.W.; Cunningham, R.P.; Kow, Y.W.
A common mechanism of action for the N-glycosylase activity of DNA N-glycosylase/AP lyases from E. coli and T4
Mutat. Res.
364
193-207
1996
Tequatrovirus T4, Escherichia coli
Roldan-Arjona, T.; Garcia-Ortiz, M.V.; Ruiz-Rubio, M.; Ariza, R.R.
cDNA cloning, expression and functional characterization of an Arabidopsis thaliana homologue of the Escherichia coli DNA repair enzyme endonuclease III
Plant Mol. Biol.
44
43-52
2000
Arabidopsis thaliana (Q9SIC4), Arabidopsis thaliana
Sarker, A.H.; Ikeda, S.; Nakano, H.; Terato, H.; Ide, H.; Imai, K.; Akiyama, K.; Tsutsui, K.; Bo, Z.; Kubo, K.; Yamamoto, K.; Yasui, A.; Yoshida, M.C.; Seki, S.
Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III
J. Mol. Biol.
282
761-774
1998
Mus musculus (O35980), Mus musculus
Tom, S.; Ranalli, T.A.; Podust, V.N.; Bambara, R.A.
Regulatory roles of p21 and apurinic/apyrimidinic endonuclease 1 in base excision repair
J. Biol. Chem.
276
48781-48789
2001
Homo sapiens
Unk, I.; Haracska, L.; Johnson, R.E.; Prakash, S.; Prakash, L.
Apurinic endonuclease activity of yeast Apn2 protein
J. Biol. Chem.
275
22427-22434
2000
Saccharomyces cerevisiae
Xu, Y.j.; DeMott, M.S.; Hwang, J.T.; Greenberg, M.M.; Demple, B.
Action of human apurinic endonuclease (Ape1) on C1'-oxidized deoxyribose damage in DNA
DNA Repair
2
175-185
2003
Homo sapiens
Xu, Y.j.; Kim, E.Y.; Demple, B.
Excision of C-4'-oxidized deoxyribose lesions from double-stranded DNA by human apurinic/apyrimidinic endonuclease (Ape1 protein) and DNA polymerase b
J. Biol. Chem.
273
28837-28844
1998
Homo sapiens
Yoshida, A.; Ueda, T.
Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells
Biochem. Biophys. Res. Commun.
310
522-528
2003
Homo sapiens
You, H.J.; Swanson, R.L.; Doetsch, P.W.
Saccharomyces cerevisiae possesses two functional homologues of Escherichia coli endonuclease III
Biochemistry
37
6033-6040
1998
Saccharomyces cerevisiae
Grafstrom, R.H.; Park, L.; Grossman, L.
Enzymatic repair of pyrimidine dimer-containing DNA. A 5' dimmer DNA glycosylase: 3'apyrimidinic endonuclease mechanism from Micrococcus luteus
J. Biol. Chem.
257
13456-13474
1982
Micrococcus luteus
-
Luo, M.; Kelley, M.R.
Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone
Anticancer Res.
24
2127-2134
2004
Homo sapiens
Khurshid, R.; Salim, A.; Abbasi, A.
Three-dimensional structure prediction of bovine AP lyase, BAP1: prediction of interaction with DNA and alterations as a result of Arg176-->Ala, Asp282-->Ala, and His308-->Asn mutations
Biochem. Biophys. Res. Commun.
326
711-717
2005
Bos taurus (P23196), Bos taurus
Izumi, T.; Schein, C.H.; Oezguen, N.; Feng, Y.; Braun, W.
Effects of backbone contacts 3' to the abasic site on the cleavage and the product binding by human apurinic/apyrimidinic endonuclease (APE1)
Biochemistry
43
684-689
2004
Homo sapiens (P27695), Homo sapiens
Greenberg, M.M.; Weledji, Y.N.; Kim, J.; Bales, B.C.
Repair of oxidized abasic sites by exonuclease III, endonuclease IV, and endonuclease III
Biochemistry
43
8178-8183
2004
Escherichia coli
Mundle, S.T.; Fattal, M.H.; Melo, L.F.; Coriolan, J.D.; O'Regan, N.E.; Strauss, P.R.
Novel role of tyrosine in catalysis by human AP endonuclease 1
DNA Repair
3
1447-1455
2004
Homo sapiens
Lindahl, T.; Verly, W.G.; Paquette, Y.
Inroads into base excision repair I. The discovery of apurinic/apyrimidinic (AP) endonuclease. "An endonuclease for depurinated DNA in Escherichia coli B," Canadian Journal of Biochemistry, 1972
DNA Repair
3
1522-1530
2004
Escherichia coli B
Marenstein, D.R.; Wilson, D.M., 3rd; Teebor, G.W.
Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA
DNA Repair
3
527-533
2004
Homo sapiens
Cistulli, C.; Lavrik, O.I.; Prasad, R.; Hou, E.; Wilson, S.H.
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate
DNA Repair
3
581-591
2004
Mus musculus
Shatilla, A.; Leduc, A.; Yang, X.; Ramotar, D.
Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation
DNA Repair
4
655-670
2005
Caenorhabditis elegans
Ali, M.M.; Hazra, T.K.; Hong, D.; Kow, Y.W.
Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil
DNA Repair
4
679-686
2005
Homo sapiens
Faustoferri, R.C.; Hahn, K.; Weiss, K.; Quivey, R.G., Jr.
Smx nuclease is the major, low-pH-inducible apurinic/apyrimidinic endonuclease in Streptococcus mutans
J. Bacteriol.
187
2705-2714
2005
Streptococcus mutans (Q9AIV4), Streptococcus mutans, Streptococcus mutans GS-5 (Q9AIV4)
Salas-Pacheco, J.M.; Setlow, B.; Setlow, P.; Pedraza-Reyes, M.
Role of the Nfo (YqfS) and ExoA apurinic/apyrimidinic endonucleases in protecting Bacillus subtilis spores from DNA damage
J. Bacteriol.
187
7374-7381
2005
Bacillus subtilis
Katafuchi, A.; Nakano, T.; Masaoka, A.; Terato, H.; Iwai, S.; Hanaoka, F.; Ide, H.
Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions
J. Biol. Chem.
279
14464-14471
2004
Escherichia coli
Watanabe, T.; Blaisdell, J.O.; Wallace, S.S.; Bond, J.P.
Engineering functional changes in Escherichia coli endonuclease III based on phylogenetic and structural analyses
J. Biol. Chem.
280
34378-34384
2005
Escherichia coli
Xia, L.; Zheng, L.; Lee, H.W.; Bates, S.E.; Federico, L.; Shen, B.; O'Connor, T.R.
Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease
J. Mol. Biol.
346
1259-1274
2005
Homo sapiens
Gallego, C.; Estevez, A.M.; Farez, E.; Ruiz-Perez, L.M.; Gonzalez-Pacanowska, D.
Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide
Mol. Biochem. Parasitol.
141
191-197
2005
Leishmania major
Wang, D.; Luo, M.; Kelley, M.R.
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition
Mol. Cancer Ther.
3
679-686
2004
Homo sapiens
Beloglazova, N.G.; Kirpota, O.O.; Starostin, K.V.; Ishchenko, A.A.; Yamkovoy, V.I.; Zharkov, D.O.; Douglas, K.T.; Nevinsky, G.A.
Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta
Nucleic Acids Res.
32
5134-5146
2004
Homo sapiens
van der Kemp, P.A.; Charbonnier, J.B.; Audebert, M.; Boiteux, S.
Catalytic and DNA-binding properties of the human Ogg1 DNA N-glycosylase/AP lyase: biochemical exploration of H270, Q315 and F319, three amino acids of the 8-oxoguanine-binding pocket
Nucleic Acids Res.
32
570-578
2004
Homo sapiens (O15527), Homo sapiens
Gros, L.; Ishchenko, A.A.; Ide, H.; Elder, R.H.; Saparbaev, M.K.
The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway
Nucleic Acids Res.
32
73-81
2004
Homo sapiens
Sukhanova, M.V.; Khodyreva, S.N.; Lebedeva, N.A.; Prasad, R.; Wilson, S.H.; Lavrik, O.I.
Human base excision repair enzymes apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymerase b and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity
Nucleic Acids Res.
33
1222-1229
2005
Homo sapiens
Jackson, E.B.; Theriot, C.A.; Chattopadhyay, R.; Mitra, S.; Izumi, T.
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1)
Nucleic Acids Res.
33
3303-3312
2005
Homo sapiens
Chang, I.Y.; Kim, S.H.; Cho, H.J.; Lee do, Y.; Kim, M.H.; Chung, M.H.; You, H.J.
Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability
Nucleic Acids Res.
33
5073-5081
2005
Homo sapiens
Doi, Y.; Katafuchi, A.; Fujiwara, Y.; Hitomi, K.; Tainer, J.A.; Ide, H.; Iwai, S.
Synthesis and characterization of oligonucleotides containing 2'-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction
Nucleic Acids Res.
34
1540-1551
2006
Escherichia coli
Izumi, T.; Brown, D.B.; Naidu, C.V.; Bhakat, K.K.; Macinnes, M.A.; Saito, H.; Chen, D.J.; Mitra, S.
Two essential but distinct functions of the mammalian abasic endonuclease
Proc. Natl. Acad. Sci. USA
102
5739-5743
2005
Mus musculus
Kropachev, K.Y.; Zharkov, D.O.; Grollman, A.P.
Catalytic mechanism of Escherichia coli endonuclease VIII: roles of the intercalation loop and the zinc finger
Biochemistry
45
12039-12049
2006
Escherichia coli (P50465), Escherichia coli
Dyrkheeva, N.S.; Lomzov, A.A.; Pyshnyi, D.V.; Khodyreva, S.N.; Lavrik, O.I.
Efficiency of exonucleolytic action of apurinic/apyrimidinic endonuclease 1 towards matched and mismatched dNMP at the 3 terminus of different oligomeric DNA structures correlates with thermal stability of DNA duplexes
Biochim. Biophys. Acta
1764
699-706
2006
Homo sapiens
Kaneda, K.; Ohishi, K.; Sekiguchi, J.; Shida, T.
Characterization of the AP endonucleases from Thermoplasma volcanium and Lactobacillus plantarum: Contributions of two important tryptophan residues to AP site recognition
Biosci. Biotechnol. Biochem.
70
2213-2221
2006
Escherichia coli, Lactiplantibacillus plantarum, Thermoplasma volcanium
Raffoul, J.J.; Banerjee, S.; Singh-Gupta, V.; Knoll, Z.E.; Fite, A.; Zhang, H.; Abrams, J.; Sarkar, F.H.; Hillman, G.G.
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo
Cancer Res.
67
2141-2149
2007
Homo sapiens, Mus musculus
Sidorenko, V.S.; Nevinsky, G.A.; Zharkov, D.O.
Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease
DNA Repair
6
317-328
2007
Homo sapiens
Mitra, S.; Izumi, T.; Boldogh, I.; Bhakat, K.K.; Chattopadhyay, R.; Szczesny, B.
Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein
DNA Repair
6
461-469
2007
Mus musculus
Carpenter, E.P.; Corbett, A.; Thomson, H.; Adacha, J.; Jensen, K.; Bergeron, J.; Kasampalidis, I.; Exley, R.; Winterbotham, M.; Tang, C.; Baldwin, G.S.; Freemont, P.
AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis
EMBO J.
26
1363-1372
2007
Neisseria meningitidis
Kanno, S.; Kuzuoka, H.; Sasao, S.; Hong, Z.; Lan, L.; Nakajima, S.; Yasui, A.
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses
EMBO J.
26
2094-2103
2007
Homo sapiens
Yang, B.; Chen, K.; Zhang, C.; Huang, S.; Zhang, H.
Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA
J. Biol. Chem.
282
11667-11675
2007
Homo sapiens
Liu, Y.; Prasad, R.; Beard, W.A.; Kedar, P.S.; Hou, E.W.; Shock, D.D.; Wilson, S.H.
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta
J. Biol. Chem.
282
13532-13541
2007
Homo sapiens
Maher, R.L.; Bloom, L.B.
Pre-steady-state kinetic characterization of the AP endonuclease activity of human AP endonuclease 1
J. Biol. Chem.
282
30577-30585
2007
Homo sapiens
Adhikari, S.; Uren, A.; Roy, R.
Dipole-dipole interaction stabilizes the transition state of apurinic/apyrimidinic endonuclease-abasic site interaction
J. Biol. Chem.
283
1334-1339
2008
Homo sapiens
OHara, A.M.; Bhattacharyya, A.; Mifflin, R.C.; Smith, M.F.; Ryan, K.A.; Scott, K.G.; Naganuma, M.; Casola, A.; Izumi, T.; Mitra, S.; Ernst, P.B.; Crowe, S.E.
Interleukin-8 induction by Helicobacter pylori in gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1
J. Immunol.
177
7990-7999
2006
Homo sapiens
Vidal, A.E.; Harkiolaki, M.; Gallego, C.; Castillo-Acosta, V.M.; Ruiz-Perez, L.M.; Wilson, K.; Gonzalez-Pacanowska, D.
Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major
J. Mol. Biol.
373
827-838
2007
Leishmania major (O15922), Leishmania major
Ho, R.; Rachek, L.I.; Xu, Y.; Kelley, M.R.; LeDoux, S.P.; Wilson, G.L.
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress
J. Neurochem.
102
13-24
2007
Saccharomyces cerevisiae (P22936)
Redrejo-Rodriguez, M.; Garcia-Escudero, R.; Yanez-Munoz, R.J.; Salas, M.L.; Salas, J.
African swine fever virus protein pE296R is a DNA repair apurinic/apyrimidinic endonuclease required for virus growth in swine macrophages
J. Virol.
80
4847-4857
2006
African swine fever virus
Lam, W.; Park, S.Y.; Leung, C.H.; Cheng, Y.C.
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2,3-dideoxy-2,3-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs
Mol. Pharmacol.
69
1607-1614
2006
Homo sapiens
Chattopadhyay, R.; Wiederhold, L.; Szczesny, B.; Boldogh, I.; Hazra, T.K.; Izumi, T.; Mitra, S.
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells
Nucleic Acids Res.
34
2067-2076
2006
Bos taurus (P23196), Bos taurus, Homo sapiens
Wong, H.K.; Muftuoglu, M.; Beck, G.; Imam, S.Z.; Bohr, V.A.; Wilson, D.M.
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates
Nucleic Acids Res.
35
4103-4113
2007
Homo sapiens
Hecker, A.; Leulliot, N.; Gadelle, D.; Graille, M.; Justome, A.; Dorlet, P.; Brochier, C.; Quevillon-Cheruel, S.; Le Cam, E.; van Tilbeurgh, H.; Forterre, P.
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro
Nucleic Acids Res.
35
6042-6051
2007
Pyrococcus abyssi
Zaky, A.; Busso, C.; Izumi, T.; Chattopadhyay, R.; Bassiouny, A.; Mitra, S.; Bhakat, K.K.
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage
Nucleic Acids Res.
36
1555-1566
2008
Homo sapiens
Peddi, S.R.; Chattopadhyay, R.; Naidu, C.V.; Izumi, T.
The human apurinic/apyrimidinic endonuclease-1 suppresses activation of poly(adp-ribose) polymerase-1 induced by DNA single strand breaks
Toxicology
224
44-55
2006
Homo sapiens (P27695), Homo sapiens
Jeon, B.H.; Irani, K.
APE1/Ref-1: Versatility in Progress
Antioxid. Redox Signal.
11
571-573
2008
Homo sapiens
Yuk, J.M.; Yang, C.S.; Shin, D.M.; Kim, K.K.; Lee, S.K.; Song, Y.J.; Lee, H.M.; Cho, C.H.; Jeon, B.H.; Jo, E.K.
A Dual Regulatory Role of Apurinic/apyrimidinic Endonuclease 1/Redox Factor-1 in HMGB1-induced Inflammatory Responses
Antioxid. Redox Signal.
11
575-587
2008
Homo sapiens
Tell, G.; Quadrifoglio, F.; Tiribelli, C.; Kelley, M.R.
The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme
Antioxid. Redox Signal.
11
601-619
2008
Homo sapiens (P27695)
Yang, S.; Meyskens, F.L.
Apurinic/apyrimidinic endonuclease /redox effector factor-1 (APE/Ref-1) a unique target for the prevention and treatment of human melanoma
Antioxid. Redox Signal.
11
639-650
2008
Homo sapiens
Park, W.S.; Ko, E.A.; Jung, I.D.; Son, Y.K.; Kim, H.K.; Kim, N.; Park, S.Y.; Hong, K.W.; Park, Y.M.; Choi, T.H.; Han, J.
APE1/Ref-1 promotes the effect of angiotensin II on Ca2+-activated K+ channel in human endothelial cells via suppression of NADPH oxidase
Arch. Pharm. Res.
31
1291-1301
2008
Homo sapiens
Mundle, S.T.; Delaney, J.C.; Essigmann, J.M.; Strauss, P.R.
Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate
Biochemistry
48
19-26
2009
Homo sapiens
Dyrkheeva, N.S.; Khodyreva, S.N.; Lavrik, O.I.
Interaction of APE1 and other repair proteins with DNA duplexes imitating intermediates of DNA repair and replication
Biochemistry (Moscow)
73
261-272
2008
Mus musculus
Jiang, Y.; Guo, C.; Vasko, M.R.; Kelley, M.R.
Implications of apurinic/apyrimidinic endonuclease in reactive oxygen signaling response after cisplatin treatment of dorsal root ganglion neurons
Cancer Res.
68
6425-6434
2008
Rattus norvegicus
Guay, D.; Garand, C.; Reddy, S.; Schmutte, C.; Lebel, M.
The human endonuclease III enzyme is a relevant target to potentiate cisplatin cytotoxicity in Y-box-binding protein-1 overexpressing tumor cells
Cancer Sci.
99
762-769
2008
Homo sapiens
Schmiedel, R.; Kuettner, E.B.; Keim, A.; Straeter, N.; Greiner-Stoeffele, T.
Structure and function of the abasic site specificity pocket of an AP endonuclease from Archaeoglobus fulgidus
DNA Repair
8
219-231
2009
Archaeoglobus fulgidus (O29675), Archaeoglobus fulgidus
Tomasi, M.L.; Iglesias-Ara, A.; Yang, H.; Ramani, K.; Feo, F.; Pascale, M.R.; Luz Martinez-Chantar, M.; Mato, J.M.; Lu, S.C.
S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis
Gastroenterology
136
1025-1036
2009
Mus musculus
Futagami, S.; Hiratsuka, T.; Shindo, T.; Horie, A.; Hamamoto, T.; Suzuki, K.; Kusunoki, M.; Miyake, K.; Gudis, K.; Crowe, S.E.; Tsukui, T.; Sakamoto, C.
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer
Helicobacter
13
209-218
2008
Homo sapiens
Lipton, A.S.; Heck, R.W.; Primak, S.; McNeill, D.R.; Wilson, D.M.; Ellis, P.D.
Characterization of Mg2+ binding to the DNA repair protein apurinic/apyrimidic endonuclease 1 via solid-state 25Mg NMR spectroscopy
J. Am. Chem. Soc.
130
9332-9341
2008
Homo sapiens (P27695)
Ibarra, J.R.; Orozco, A.D.; Rojas, J.A.; Lopez, K.; Setlow, P.; Yasbin, R.E.; Pedraza-Reyes, M.
Role of the Nfo and ExoA apurinic/apyrimidinic endonucleases in repair of DNA damage during outgrowth of Bacillus subtilis spores
J. Bacteriol.
190
2031-2038
2008
Bacillus subtilis
Agger, S.A.; Lopez-Gallego, F.; Hoye, T.R.; Schmidt-Dannert, C.
Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. strain PCC 7120
J. Bacteriol.
190
6084-6096
2008
Saccharomyces cerevisiae
Zhao, J.; Gao, F.; Zhang, Y.; Wei, K.; Liu, Y.; Deng, X.
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity
J. Biol. Chem.
283
9925-9932
2008
Homo sapiens
Zawahir, Z.; Dayam, R.; Deng, J.; Pereira, C.; Neamati, N.
Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitors
J. Med. Chem.
52
20-32
2009
Homo sapiens (P27695), Homo sapiens
Berquist, B.R.; McNeill, D.R.; Wilson, D.M.
Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision
J. Mol. Biol.
379
17-27
2008
Homo sapiens
Mantha, A.K.; Oezguen, N.; Bhakat, K.K.; Izumi, T.; Braun, W.; Mitra, S.
Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1
J. Mol. Biol.
379
28-37
2008
Homo sapiens
Kim, M.H.; Kim, H.B.; Acharya, S.; Sohn, H.M.; Jun, J.Y.; Chang, I.Y.; You, H.J.
Ape1/Ref-1 induces GDNF responsiveness by upregulating GFRalpha1 expression
Mol. Cell. Biol.
29
2264-2277
2009
Homo sapiens
Merluzzi, S.; Gri, G.; Gattei, V.; Pagano, M.; Pucillo, C.
APE/Ref-1 makes fine-tuning of CD40-induced B cell proliferation
Mol. Immunol.
45
3731-3739
2008
Mus musculus
Georgiadis, M.M.; Luo, M.; Gaur, R.K.; Delaplane, S.; Li, X.; Kelley, M.R.
Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
Mutat. Res.
643
54-63
2008
Danio rerio, Homo sapiens
Garcin, E.D.; Hosfield, D.J.; Desai, S.A.; Haas, B.J.; Bjoeras, M.; Cunningham, R.P.; Tainer, J.A.
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV
Nat. Struct. Mol. Biol.
15
515-522
2008
Escherichia coli, Escherichia coli BW565DE3
Castillo-Acosta, V.M.; Ruiz-Perez, L.M.; Yang, W.; Gonzalez-Pacanowska, D.; Vidal, A.E.
Identification of a residue critical for the excision of 3-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family
Nucleic Acids Res.
37
1829-1842
2009
Homo sapiens, Leishmania major
Dagci, T.; Armagan, G.; Konyalioglu, S.; Yalcin, A.
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells
Physiol. Res.
58
427-434
2008
Rattus norvegicus
Bogani, F.; Boehmer, P.E.
The replicative DNA polymerase of herpes simplex virus 1 exhibits apurinic/apyrimidinic and 5-deoxyribose phosphate lyase activities
Proc. Natl. Acad. Sci. USA
105
11709-11714
2008
Human alphaherpesvirus 1
Kim, S.E.; Gorrell, A.; Rader, S.D.; Lee, C.H.
Endoribonuclease activity of human apurinic/apyrimidinic endonuclease 1 revealed by a real-time fluorometric assay
Anal. Biochem.
398
69-75
2010
Homo sapiens, Rattus norvegicus
Bhakat, K.; Mantha, A.; Mitra, S.
Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein
Antioxid. Redox Signal.
11
621-637
2009
Homo sapiens
Fortier, S.; Yang, X.; Wang, Y.; Bennett, R.A.; Strauss, P.R.
Base excision repair in early zebrafish development: evidence for DNA polymerase switching and standby AP endonuclease activity
Biochemistry
48
5396-5404
2009
Danio rerio
Baldwin, M.R.; OBrien, P.J.
Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylase
Biochemistry
48
6022-6033
2009
Homo sapiens
Al-Attar, A.; Gossage, L.; Fareed, K.R.; Shehata, M.; Mohammed, M.; Zaitoun, A.M.; Soomro, I.; Lobo, D.N.; Abbotts, R.; Chan, S.; Madhusudan, S.
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers
Br. J. Cancer
102
704-709
2010
Homo sapiens
Chattopadhyay, R.; Bhattacharyya, A.; Crowe, S.E.
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection
Cancer Res.
70
2799-2808
2010
Homo sapiens
Barraza-Salas, M.; Ibarra-Rodriguez, J.R.; Mellado, S.J.; Salas-Pacheco, J.M.; Setlow, P.; Pedraza-Reyes, M.
Effects of forespore-specific overexpression of apurinic/apyrimidinic endonuclease Nfo on the DNA-damage resistance properties of Bacillus subtilis spores
FEMS Microbiol. Lett.
302
159-165
2010
Bacillus subtilis, Bacillus subtilis PS832
Harris, J.L.; Jakob, B.; Taucher-Scholz, G.; Dianov, G.L.; Becherel, O.J.; Lavin, M.F.
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage
Hum. Mol. Genet.
18
4102-4117
2009
Homo sapiens
Li, M.; Zhong, Z.; Zhu, J.; Xiang, D.; Dai, N.; Cao, X.; Qing, Y.; Yang, Z.; Xie, J.; Li, Z.; Baugh, L.; Wang, G.; Wang, D.
Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1
J. Biol. Chem.
285
14871-14881
2010
Homo sapiens
Timofeyeva, N.A.; Koval, V.V.; Knorre, D.G.; Zharkov, D.O.; Saparbaev, M.K.; Ishchenko, A.A.; Fedorova, O.S.
Conformational dynamics of human AP endonuclease in base excision and nucleotide incision repair pathways
J. Biomol. Struct. Dyn.
26
637-652
2009
Homo sapiens
Lee, H.M.; Yuk, J.M.; Shin, D.M.; Yang, C.S.; Kim, K.K.; Choi, D.K.; Liang, Z.L.; Kim, J.M.; Jeon, B.H.; Kim, C.D.; Lee, J.H.; Jo, E.K.
Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses
J. Immunol.
183
6839-6848
2009
Homo sapiens
Bapat, A.; Glass, L.S.; Luo, M.; Fishel, M.L.; Long, E.C.; Georgiadis, M.M.; Kelley, M.R.
Novel small molecule inhibitor of Ape1 endonuclease blocks proliferation and reduces viability of glioblastoma cells
J. Pharmacol. Exp. Ther.
334
988-998
2010
Homo sapiens
Curtis, C.D.; Thorngren, D.L.; Ziegler, Y.S.; Sarkeshik, A.; Yates, J.R.; Nardulli, A.M.
Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression
Mol. Endocrinol.
23
1346-1359
2009
Homo sapiens
Roberts, S.A.; Strande, N.; Burkhalter, M.D.; Strom, C.; Havener, J.M.; Hasty, P.; Ramsden, D.A.
Ku is a 5-dRP/AP lyase that excises nucleotide damage near broken ends
Nature
464
1214-1217
2010
Homo sapiens
Zhang-Akiyama, Q.M.; Morinaga, H.; Kikuchi, M.; Yonekura, S.; Sugiyama, H.; Yamamoto, K.; Yonei, S.
KsgA, a 16S rRNA adenine methyltransferase, has a novel DNA glycosylase/AP lyase activity to prevent mutations in Escherichia coli
Nucleic Acids Res.
37
2116-2125
2009
Escherichia coli, Escherichia coli KSR7
Barnes, T.; Kim, W.C.; Mantha, A.K.; Kim, S.E.; Izumi, T.; Mitra, S.; Lee, C.H.
Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA
Nucleic Acids Res.
37
3946-3958
2009
Homo sapiens, Rattus norvegicus
Kiyonari, S.; Tahara, S.; Shirai, T.; Iwai, S.; Ishino, S.; Ishino, Y.
Biochemical properties and base excision repair complex formation of apurinic/apyrimidinic endonuclease from Pyrococcus furiosus
Nucleic Acids Res.
37
6439-6453
2009
Pyrococcus furiosus (Q8U437), Pyrococcus furiosus
Wu, H.H.; Cheng, Y.W.; Chang, J.T.; Wu, T.C.; Liu, W.S.; Chen, C.Y.; Lee, H.
Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation
Oncogene
29
4330-4340
2010
Homo sapiens
Simeonov, A.; Kulkarni, A.; Dorjsuren, D.; Jadhav, A.; Shen, M.; McNeill, D.R.; Austin, C.P.; Wilson, D.M.
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1
PLoS ONE
4
e5740
2009
Homo sapiens
Stetler, R.A.; Gao, Y.; Zukin, R.S.; Vosler, P.S.; Zhang, L.; Zhang, F.; Cao, G.; Bennett, M.V.; Chen, J.
Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia
Proc. Natl. Acad. Sci. USA
107
3204-3209
2010
Rattus norvegicus
Redrejo-Rodriguez, M.; Ishchenko, A.A.; Saparbaev, M.K.; Salas, M.L.; Salas, J.
African swine fever virus AP endonuclease is a redox-sensitive enzyme that repairs alkylating and oxidative damage to DNA
Virology
390
102-109
2009
African swine fever virus
Asano, R.; Ishikawa, H.; Nakane, S.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
An additional C-terminal loop in endonuclease IV, an apurinic/apyrimidinic endonuclease, controls binding affinity to DNA
Acta Crystallogr. Sect. D
67
149-155
2011
Geobacillus kaustophilus (Q5KX27)
Jedinak, A.; Dudhgaonkar, S.; Kelley, M.R.; Sliva, D.
Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages
Anticancer Res.
31
379-385
2011
Mus musculus
Yu, E.; Gaucher, S.P.; Hadi, M.Z.
Probing conformational changes in Ape1 during the progression of base excision repair
Biochemistry
49
3786-3796
2010
Homo sapiens
Kanazhevskaya, L.Y.; Koval, V.V.; Zharkov, D.O.; Strauss, P.R.; Fedorova, O.S.
Conformational transitions in human AP endonuclease 1 and its active site mutant during abasic site repair
Biochemistry
49
6451-6461
2010
Homo sapiens
Su, D.; Delaplane, S.; Luo, M.; Rempel, D.; Vu, B.; Kelley, M.; Gross, M.; Georgiadis, M.
Interactions of apurinic/apyrimidinic endonuclease with a redox inhibitor: Evidence for an alternate conformation of the enzyme
Biochemistry
50
82-92
2011
Homo sapiens
Laerdahl, J.K.; Korvald, H.; Nilsen, L.; Dahl-Michelsen, K.; Rognes, T.; Bjoras, M.; Alseth, I.
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1
DNA Repair
10
296-305
2011
Schizosaccharomyces pombe (P50525), Schizosaccharomyces pombe
Onyango, D.O.; Naguleswaran, A.; Delaplane, S.; Reed, A.; Kelley, M.R.; Georgiadis, M.M.; Sullivan, W.J.
Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii
DNA Repair
10
466-475
2011
Toxoplasma gondii (F6KAZ5)
Borjigin, M.; Martinez, B.; Purohit, S.; de la Rosa, G.; Arenaz, P.; Stec, B.
Chinese hamster apurinic/apyrimidinic endonuclease (chAPE1) expressed in sf9 cells reveals that its endonuclease activity is regulated by phosphorylation
FEBS J.
277
4732-4740
2010
Cricetulus griseus
Moeller, R.; Setlow, P.; Pedraza-Reyes, M.; Okayasu, R.; Reitz, G.; Nicholson, W.
Role of the Nfo and ExoA apurinic/apyrimidinic endonucleases in radiation resistance and radiation-induced mutagenesis of Bacillus subtilis spores
J. Bacteriol.
193
2875-2879
2011
Bacillus subtilis
Guikema, J.E.; Gerstein, R.M.; Linehan, E.K.; Cloherty, E.K.; Evan-Browning, E.; Tsuchimoto, D.; Nakabeppu, Y.; Schrader, C.E.
Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge
J. Immunol.
186
1943-1950
2011
Mus musculus
Kim, W.C.; Berquist, B.R.; Chohan, M.; Uy, C.; Wilson, D.M.; Lee, C.H.
Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1
J. Mol. Biol.
411
960-971
2011
Homo sapiens
Cho, K.J.; Kim, H.J.; Park, S.C.; Kim, H.W.; Kim, G.W.
Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death
Mol. Cell. Neurosci.
45
267-276
2010
Mus musculus
Banos, B.; Villar, L.; Salas, M.; de Vega, M.
Intrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites
Proc. Natl. Acad. Sci. USA
107
19219-19224
2010
Bacillus subtilis
Lingaraju, G.M.; Prota, A.E.; Winkler, F.K.
Mutational studies of Pa-AGOG DNA glycosylase from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum
DNA Repair
8
857-864
2009
Pyrobaculum aerophilum (Q8ZVK6), Pyrobaculum aerophilum, Pyrobaculum aerophilum DSM 7523 (Q8ZVK6)
Gogos, A.; Clarke, N.D.
Characterization of an 8-oxoguanine DNA glycosylase from Methanococcus jannaschii
J. Biol. Chem.
274
30447-30450
1999
Methanocaldococcus jannaschii (Q58134), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58134)
Faucher, F.; Wallace, S.S.; Doubli, S.
The C-terminal lysine of Ogg2 DNA glycosylases is a major molecular determinant for guanine/8-oxoguanine distinction
J. Mol. Biol.
397
46-56
2010
Methanocaldococcus jannaschii (Q58134), Methanocaldococcus jannaschii DSM 2661 (Q58134)
Chung, J.H.; Suh, M.J.; Park, Y.I.; Tainer, J.A.; Han, Y.S.
Repair activities of 8-oxoguanine DNA glycosylase from Archaeoglobus fulgidus, a hyperthermophilic archaeon
Mutat. Res.
486
99-111
2001
Archaeoglobus fulgidus (O29876), Archaeoglobus fulgidus
Sartori, A.A.; Lingaraju, G.M.; Hunziker, P.; Winkler, F.K.; Jiricny, J.
Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases
Nucleic Acids Res.
32
6531-6539
2004
Pyrobaculum aerophilum (Q8ZVK6), Pyrobaculum aerophilum, Pyrobaculum aerophilum DSM 7523 (Q8ZVK6)
Lingaraju, G.M.; Sartori, A.A.; Kostrewa, D.; Prota, A.E.; Jiricny, J.; Winkler, F.K.
A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure
Structure
13
87-98
2005
Pyrobaculum aerophilum (Q8ZVK6), Pyrobaculum aerophilum, Pyrobaculum aerophilum DSM 7523 (Q8ZVK6)
Manvilla, B.A.; Pozharski, E.; Toth, E.A.; Drohat, A.C.
Structure of human apurinic/apyrimidinic endonuclease 1 with the essential Mg2+ cofactor
Acta Crystallogr. Sect. D
69
2555-2562
2013
Homo sapiens (P27695), Homo sapiens
Srinivasan, A.; Wang, L.; Cline, C.J.; Xie, Z.; Sobol, R.W.; Xie, X.Q.; Gold, B.
Identification and characterization of human apurinic/apyrimidinic endonuclease-1 inhibitors
Biochemistry
51
6246-6259
2012
Homo sapiens (P27695), Homo sapiens
Charret, K.S.; Requena, C.E.; Castillo-Acosta, V.M.; Ruiz-Perez, L.M.; Gonzalez-Pacanowska, D.; Vidal, A.E.
Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents
DNA Repair
11
53-64
2012
Trypanosoma brucei, Trypanosoma brucei 449
Sepulveda, S.; Valenzuela, L.; Ponce, I.; Sierra, S.; Bahamondes, P.; Ramirez, S.; Rojas, V.; Kemmerling, U.; Galanti, N.; Cabrera, G.
Expression, functionality, and localization of apurinic/apyrimidinic endonucleases in replicative and non-replicative forms of Trypanosoma cruzi
J. Cell. Biochem.
115
397-409
2014
Trypanosoma cruzi (T1SGV2), Trypanosoma cruzi (T1SHD4), Trypanosoma cruzi, Trypanosoma cruzi Dm28c (T1SGV2), Trypanosoma cruzi Dm28c (T1SHD4)
Adhikari, S.; Manthena, P.V.; Kota, K.K.; Karmahapatra, S.K.; Roy, G.; Saxena, R.; Uren, A.; Roy, R.
A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease
Mol. Cell. Biochem.
362
195-201
2012
Homo sapiens (P27695), Homo sapiens, Mus musculus (P28352), Mus musculus
Broxson, C.; Hayner, J.N.; Beckett, J.; Bloom, L.B.; Tornaletti, S.
Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA
Nucleic Acids Res.
42
7708-7719
2014
Homo sapiens
Joldybayeva, B.; Prorok, P.; Grin, I.R.; Zharkov, D.O.; Ishenko, A.A.; Tudek, B.; Bissenbaev, A.K.; Saparbaev, M.
Cloning and characterization of a wheat homologue of apurinic/apyrimidinic endonuclease Ape1L
PLoS ONE
9
e92963
2014
Triticum aestivum
Madlener, S.; Stroebel, T.; Vose, S.; Saydam, O.; Price, B.D.; Demple, B.; Saydam, N.
Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance
Proc. Natl. Acad. Sci. USA
110
17844-17849
2013
Homo sapiens (P27695), Homo sapiens
Yan, Z.; Yuan, Z.; Ni, J.; Gu, L.; Shen, Y.
Crystal structure of the crenarchaeal ExoIII AP endonuclease SisExoIII reveals a conserved disulfide bond endowing the protein with thermostability
Biochem. Biophys. Res. Commun.
490
774-779
2017
Sulfolobus islandicus (F0NEW7), Sulfolobus islandicus Rey15A (F0NEW7), Sulfolobus islandicus Rey15A
Dyrkheeva, N.S.; Lebedeva, N.A.; Lavrik, O.I.
AP endonuclease 1 as a key enzyme in repair of apurinic/apyrimidinic sites
Biochemistry (Moscow)
81
951-967
2016
Homo sapiens (P27695), Homo sapiens, Mus musculus (P28352)
Dyakonova, E.S.; Koval, V.V.; Lomzov, A.A.; Ishchenko, A.A.; Fedorova, O.S.
The role of His-83 of yeast apurinic/apyrimidinic endonuclease Apn1 in catalytic incision of abasic sites in DNA
Biochim. Biophys. Acta
1850
1297-1309
2015
Saccharomyces cerevisiae (P22936), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 / S288c (P22936)
Ilina, E.S.; Khodyreva, S.N.; Lavrik, O.I.
Unusual interaction of human apurinic/apyrimidinic endonuclease 1 (APE1) with abasic sites via the Schiff-base-dependent mechanism
Biochimie
150
88-99
2018
Homo sapiens (P27695), Homo sapiens
Dyakonova, E.S.; Koval, V.V.; Lomzov, A.A.; Ishchenko, A.A.; Fedorova, O.S.
Apurinic/apyrimidinic endonuclease Apn1 from Saccharomyces cerevisiae is recruited to the nucleotide incision repair pathway Kinetic and structural features
Biochimie
152
53-62
2018
Saccharomyces cerevisiae (P22936), Saccharomyces cerevisiae ATCC 204508 / S288c (P22936)
Laev, S.S.; Salakhutdinov, N.F.; Lavrik, O.I.
Inhibitors of nuclease and redox activity of apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1)
Bioorg. Med. Chem.
25
2531-2544
2017
Homo sapiens (P27695), Homo sapiens (Q9UBZ4), Homo sapiens
Jiang, X.; Shan, J.; Dai, N.; Zhong, Z.; Qing, Y.; Yang, Y.; Zhang, S.; Li, C.; Sui, J.; Ren, T.; Li, M.; Wang, D.
Apurinic/apyrimidinic endonuclease 1 regulates angiogenesis in a transforming growth factor beta-dependent manner in human osteosarcoma
Cancer Sci.
106
1394-1401
2015
Homo sapiens (P27695), Homo sapiens
Guerreiro, P.S.; Estacio, S.G.; Antunes, F.; Fernandes, A.S.; Pinheiro, P.F.; Costa, J.G.; Castro, M.; Miranda, J.P.; Guedes, R.C.; Oliveira, N.G.
Structure-based virtual screening toward the discovery of novel inhibitors of the DNA repair activity of the human apurinic/apyrimidinic endonuclease 1
Chem. Biol. Drug Des.
88
915-925
2016
Homo sapiens (P27695), Homo sapiens
Kotera, N.; Poyer, F.; Granzhan, A.; Teulade-Fichou, M.P.
Efficient inhibition of human AP endonuclease 1 (APE1) via substrate masking by abasic site-binding macrocyclic ligands
Chem. Commun. (Camb.)
51
15948-15951
2015
Homo sapiens (P27695), Homo sapiens
Kladova, O.A.; Bazlekowa-Karaban, M.; Baconnais, S.; Pietrement, O.; Ishchenko, A.A.; Matkarimov, B.T.; Iakovlev, D.A.; Vasenko, A.; Fedorova, O.S.; Le Cam, E.; Tudek, B.; Kuznetsov, N.A.; Saparbaev, M.
The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation
DNA Repair
64
10-25
2018
Homo sapiens (P27695), Homo sapiens
Kuznetsov, N.A.; Kladova, O.A.; Kuznetsova, A.A.; Ishchenko, A.A.; Saparbaev, M.K.; Zharkov, D.O.; Fedorova, O.S.
Conformational dynamics of DNA repair by Escherichia coli endonuclease III
J. Biol. Chem.
290
14338-14349
2015
Escherichia coli (P0AB83), Escherichia coli
Miroshnikova, A.D.; Kuznetsova, A.A.; Vorobjev, Y.N.; Kuznetsov, N.A.; Fedorova, O.S.
Effects of mono- and divalent metal ions on DNA binding and catalysis of human apurinic/apyrimidinic endonuclease 1
Mol. Biosyst.
12
1527-1539
2016
Homo sapiens (P27695), Homo sapiens
Kuznetsov, N.A.; Kupryushkin, M.S.; Abramova, T.V.; Kuznetsova, A.A.; Miroshnikova, A.D.; Stetsenko, D.A.; Pyshnyi, D.V.; Fedorova, O.S.
New oligonucleotide derivatives as unreactive substrate analogues and potential inhibitors of human apurinic/apyrimidinic endonuclease APE1
Mol. Biosyst.
12
67-75
2016
Homo sapiens (P27695), Homo sapiens
Roychoudhury, S.; Nath, S.; Song, H.; Hegde, M.L.; Bellot, L.J.; Mantha, A.K.; Sengupta, S.; Ray, S.; Natarajan, A.; Bhakat, K.K.
Human apurinic/apyrimidinic endonuclease (APE1) is acetylated at DNA damage sites in chromatin, and acetylation modulates its DNA repair activity
Mol. Cell. Biol.
37
e00401-16
2017
Homo sapiens (P27695), Homo sapiens
Kuznetsova, A.A.; Fedorova, O.S.; Kuznetsov, N.A.
Kinetic features of 30-50 exonuclease activity of human AP-endonuclease APE1
Molecules
23
E2101
2018
Homo sapiens (P27695), Homo sapiens
Beaver, J.M.; Lai, Y.; Xu, M.; Casin, A.H.; Laverde, E.E.; Liu, Y.
AP endonuclease 1 prevents trinucleotide repeat expansion via a novel mechanism during base excision repair
Nucleic Acids Res.
43
5948-5960
2015
Homo sapiens (P27695), Homo sapiens
Kuznetsova, A.A.; Matveeva, A.G.; Milov, A.D.; Vorobjev, Y.N.; Dzuba, S.A.; Fedorova, O.S.; Kuznetsov, N.A.
Substrate specificity of human apurinic/apyrimidinic endonuclease APE1 in the nucleotide incision repair pathway
Nucleic Acids Res.
46
11454-11465
2018
Homo sapiens (P27695), Homo sapiens
Turgimbayeva, A.; Abeldenov, S.; Zharkov, D.O.; Ishchenko, A.A.; Ramankulov, Y.; Saparbaev, M.; Khassenov, B.
Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori
PLoS ONE
13
e0202232
2018
Helicobacter pylori (Q9ZJ98), Helicobacter pylori, Helicobacter pylori J99 / ATCC 700824 (Q9ZJ98)
Batebi, H.; Dragelj, J.; Imhof, P.
Role of AP-endonuclease (Ape1) active site residues in stabilization of the reactant enzyme-DNA complex
Proteins
86
439-453
2018
Homo sapiens (P27695)
Khanam, T.; Shukla, A.; Rai, N.; Ramachandran, R.
Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3'-5' exonuclease III
Biochim. Biophys. Acta
1854
505-516
2015
Mycobacterium tuberculosis (P96273), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P96273), Mycobacterium tuberculosis ATCC 25618 (P96273)
Khanam, T.; Rai, N.; Ramachandran, R.
Mycobacterium tuberculosis class II apurinic/apyrimidinic-endonuclease/3'-5' exonuclease III exhibits DNA regulated modes of interaction with the sliding DNA beta-clamp
Mol. Microbiol.
98
46-68
2015
Mycobacterium tuberculosis (P96273), Mycobacterium tuberculosis H37Rv (P96273), Mycobacterium tuberculosis ATCC 25618 (P96273)
html completed
