Information on EC 4.2.3.67 - cis-muuroladiene synthase

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The expected taxonomic range for this enzyme is: Mentha x piperita

EC NUMBER
COMMENTARY
4.2.3.67
-
RECOMMENDED NAME
GeneOntology No.
cis-muuroladiene synthase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
(2E,6E)-farnesyl diphosphate = cis-muurola-3,5-diene + diphosphate
show the reaction diagram
-
-
-
-
(2E,6E)-farnesyl diphosphate = cis-muurola-4(14),5-diene + diphosphate
show the reaction diagram
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
cis-calamenene related sesquiterpenoids biosynthesis
-
Sesquiterpenoid and triterpenoid biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cis-muuroladiene-forming)
The recombinant enzyme from black peppermint (Mentha x piperita) gave a mixture of cis-muurola-3,5-diene (45%) and cis-muurola-4(14),5-diene (43%).
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
MxpSS1
Q5W283
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
cis-muurola-3,5-diene + diphosphate
show the reaction diagram
-, Q5W283
-
main products cis-muurola-3,5-diene at 45% and cis-muurola-4(14),5-diene at 43%, minor products gamma-cadinene at 7% and alpha-cadinene at 5%
-
?
(2E,6E)-farnesyl diphosphate
cis-muurola-4(14),5-diene + diphosphate
show the reaction diagram
-, Q5W283
-
main products cis-muurola-3,5-diene at 45% and cis-muurola-4(14),5-diene at 43%, minor products gamma-cadinene at 7% and alpha-cadinene at 5%
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
cis-muurola-3,5-diene + diphosphate
show the reaction diagram
-, Q5W283
-
main products cis-muurola-3,5-diene at 45% and cis-muurola-4(14),5-diene at 43%, minor products gamma-cadinene at 7% and alpha-cadinene at 5%
-
?
(2E,6E)-farnesyl diphosphate
cis-muurola-4(14),5-diene + diphosphate
show the reaction diagram
-, Q5W283
-
main products cis-muurola-3,5-diene at 45% and cis-muurola-4(14),5-diene at 43%, minor products gamma-cadinene at 7% and alpha-cadinene at 5%
-
?
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.0019
-
(2E,6E)-farnesyl diphosphate
-, Q5W283
pH 7.2, 27°C
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
0.18
-
(2E,6E)-farnesyl diphosphate
-, Q5W283
pH 7.2, 27°C
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expression in Escherichia coli
-, Q5W283