Information on EC 4.2.3.62 - (-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.2.3.62
-
RECOMMENDED NAME
GeneOntology No.
(-)-gamma-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2Z,6E)-farnesyl diphosphate = (-)-gamma-cadinene + diphosphate
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(2Z,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-gamma-cadinene-forming]
Isolated from the liverwort Heteroscyphus planus. cf EC 4.2.3.92 (+)-gamma-cadinene synthase.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
Cucumis melo variety Noy Yizre'el
-
UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2Z, 6E)-farnesyl diphosphate
(-)-gamma-cadinene + diphosphate
show the reaction diagram
-
-
formation of gamma-cadinene involves a 1,3-hydride shift. (-)-gamma-Cadinene is directly formed from 2Z,6E-farnesyl diphosphate by intramolecular electrophilic attack of the primary carbocation on the C-10 position of farnesyl diphosphate. Second product: (+)-germacrene D
-
?
farnesyl diphosphate
gamma-cadinene
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2Z, 6E)-farnesyl diphosphate
(-)-gamma-cadinene + diphosphate
show the reaction diagram
-
-
formation of gamma-cadinene involves a 1,3-hydride shift. (-)-gamma-Cadinene is directly formed from 2Z,6E-farnesyl diphosphate by intramolecular electrophilic attack of the primary carbocation on the C-10 position of farnesyl diphosphate. Second product: (+)-germacrene D
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
268
-
pH 7.5, 30°C
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli