Information on EC 4.2.3.57 - (-)-beta-caryophyllene synthase

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The expected taxonomic range for this enzyme is: Spermatophyta

EC NUMBER
COMMENTARY
4.2.3.57
-
RECOMMENDED NAME
GeneOntology No.
(-)-beta-caryophyllene synthase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
(2E,6E)-farnesyl diphosphate = (-)-beta-caryophyllene + diphosphate
show the reaction diagram
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
beta-caryophyllene biosynthesis
-
oleoresin sesquiterpene volatiles biosynthesis
-
Sesquiterpenoid and triterpenoid biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(-)-beta-caryophyllene-forming]
Widely distributed in higher plants, cf. EC 4.2.3.89 (+)-beta-caryophyllene synthase.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
(E)-beta-caryophyllene synthase
-
-
TPS1
B4XAK4
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
Scots pine
UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
(E)-beta-caryophyllene + alpha-humulene + alpha-copaene + diphosphate
show the reaction diagram
-
-
alpha-humulene and alpha-copaene are minor products besides the main product (E)-beta-caryophyllene
-
?
(2E,6E)-farnesyl diphosphate
(E)-beta-caryophyllene + alpha-humulene + diphosphate
show the reaction diagram
B4XAK4
-
TPS 1 forms two main products: (E)-beta-caryophyllene and alpha-humulene with 76.3 and 23.7%, respectively
-
?
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
expressed in Escherichia coli BL21 cells
-
expressed in Escherichia coli BL21 (DH3) pLysS cells
B4XAK4
EXPRESSION
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
transcript level of TPS 1 is significantly higher in oviposition-induced twigs that are attractive to the parasitoid Diprion pini than in non-attractive, artificially damaged twigs. Transcript levels of PsTPS 1 also changes significantly over time with a striking increase 72 h after oviposition
B4XAK4