Information on EC 4.2.3.43 - fusicocca-2,10(14)-diene synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.2.3.43
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RECOMMENDED NAME
GeneOntology No.
fusicocca-2,10(14)-diene synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranylgeranyl diphosphate = fusicocca-2,10(14)-diene + diphosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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brassicicene C biosynthesis
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Diterpenoid biosynthesis
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fusicoccin A biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
geranylgeranyl diphosphate-lyase (fusicocca-2,10(14)-diene-forming)
A multifunctional enzyme with EC 2.5.1.29 farnesyltranstransferase activity.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
show the reaction diagram
geranylgeranyl diphosphate
fusicocca-2,10(14-diene) + diphosphate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
geranylgeranyl diphosphate
fusicocca-2,10(14)-diene + diphosphate
show the reaction diagram
A2PZA5
the enzyme contains two domains, an N-terminal terpene cyclase domain and a C-terminal prenyltransferase domain, and converts isoprene units sequentially into geranylgeranyl diphosphate and then into fusicocca-2,10 (14)-diene
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
expressed in Saccharomyces cerevisiae
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heterologous expression of PaFS alone results in the accumulation of fusicocca-2,10 (14)-diene in Escherichia coli cells