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Reference on EC 4.2.3.27 - isoprene synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sivy, T.L.; Shirk, M.C.; Fall, R.
Isoprene synthase activity parallels fluctuations of isoprene release during growth of Bacillus subtilis
Biochem. Biophys. Res. Commun.
294
71-75
2002
BRENDA: Bacillus subtilis, Bacillus subtilis 6051
Textmining: bacterium
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Schnitzler, J.P.; Arenz, R.; Steinbrecher, R.; Lehning, A.
Characterization of an isoprene synthase from leaves of Quercus petraea
Bot. Acta
109
216-221
1996
Quercus petraea
-
Manually annotated by BRENDA team
Sasaki, K.; Ohara, K.; Yazaki, K.
Gene expression and characterization of isoprene synthase from Populus alba
FEBS Lett.
579
2514-2518
2005
Populus alba (Q50L36), Populus alba
Manually annotated by BRENDA team
Silver, G.M.; Fall, R.
Characterization of aspen isoprene synthase, an enzyme responsible for leaf isoprene emission to the atmosphere
J. Biol. Chem.
270
13010-13016
1995
Populus tremuloides
Manually annotated by BRENDA team
Lehning, A.; Zimmer, I.; Steinbrecher, R.; Bruggemann, N.; Schnitzler, J.P.
Isoprene synthase activity and its relation to isoprene emission in Quercus robur L. leaves
Plant Cell Environ.
22
495-504
1999
Quercus robur
-
Manually annotated by BRENDA team
Calfapietra, C.; Wiberley, A.E.; Falbel, T.G.; Linskey, A.R.; Mugnozza, G.S.; Karnosky, D.F.; Loreto, F.; Sharkey, T.D.
Isoprene synthase expression and protein levels are reduced under elevated O3 but not under elevated CO2 (FACE) in field-grown aspen trees
Plant Cell Environ.
30
654-661
2007
Populus tremuloides
Manually annotated by BRENDA team
Kuzma, J.; Fall, R.
Leaf isoprene emission rate is dependent on leaf development and the level of isoprene synthase
Plant Physiol.
101
435-440
1993
BRENDA: Mucuna sp.
Textmining: Mucuna pruriens var. utilis
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Wildermuth, M.C.; Fall, R.
Light-dependent isoprene emission (characterization of a thylakoid-bound isoprene synthase in Salix discolor chloroplasts)
Plant Physiol.
112
171-182
1996
BRENDA: Salix discolor
Textmining: plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Wildermuth, M.C.; Fall, R.
Biochemical characterization of stromal and thylakoid-bound isoforms of isoprene synthase in willow leaves
Plant Physiol.
116
1111-1123
1998
BRENDA: Salix discolor
Textmining: plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Silver, G.M.; Fall, R.
Enzymatic synthesis of isoprene from dimethylallyl diphosphate in aspen leaf extracts
Plant Physiol.
97
1588-1591
1991
Populus tremuloides
Manually annotated by BRENDA team
Monson, R.K.; Jaeger, C.H.; Adams, W.W.; Driggers, E.M.; Silver, G.M.; Fall, R.
Relationships among isoprene emission rate, photosynthesis, and isoprene synthase activity as influenced by temperature
Plant Physiol.
98
1175-1180
1992
BRENDA: Mucuna pruriens
Textmining: Electron, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Miller, B.; Oschinski, C.; Zimmer, W.
First isolation of an isoprene synthase gene from poplar and successful expression of the gene in Escherichia coli
Planta
213
483-487
2001
BRENDA: Populus tremula x Populus alba (Q9AR86)
Textmining: Escherichia coli, Populus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Schnitzler, J.P.; Zimmer, I.; Bachl, A.; Arend, M.; Fromm, J.; Fischbach, R.J.
Biochemical properties of isoprene synthase in poplar (Populus x canescens)
Planta
222
777-786
2005
BRENDA: Populus tremula x Populus alba
Textmining: Populus, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Mayrhofer, S.; Teuber, M.; Zimmer, I.; Louis, S.; Fischbach, R.J.; Schnitzler, J.P.
Diurnal and seasonal variation of isoprene biosynthesis-related genes in grey poplar leaves
Plant Physiol.
139
474-484
2005
Populus
Automatic Mining of ENzyme DAta
Sharkey, T.D.; Wiberley, A.E.; Donohue, A.R.
Isoprene emission from plants: why and how
Ann. Bot.
101
5-18
2008
Embryophyta, Populus alba, Populus tremula x Populus alba, Populus tremuloides, Populus trichocarpa, Pueraria montana var. lobata
Manually annotated by BRENDA team
Brilli, F.; Barta, C.; Fortunati, A.; Lerdau, M.; Loreto, F.; Centritto, M.
Response of isoprene emission and carbon metabolism to drought in white poplar (Populus alba) saplings
New Phytol.
175
244-254
2007
Populus alba
Manually annotated by BRENDA team
Wiberley, A.E.; Donohue, A.R.; Meier, M.E.; Westphal, M.M.; Sharkey, T.D.
Regulation of isoprene emission in Populus trichocarpa leaves subjected to changing growth temperature
Plant Cell Environ.
31
258-267
2008
Populus trichocarpa
Manually annotated by BRENDA team
Sasaki, K.; Saito, T.; Laemsae, M.; Oksman-Caldentey, K.M.; Suzuki, M.; Ohyama, K.; Muranaka, T.; Ohara, K.; Yazaki, K.
Plants utilize isoprene emission as a thermotolerance mechanism
Plant Cell Physiol.
48
1254-1262
2007
BRENDA: Populus alba (Q50L36), Populus alba
Textmining: Arabidopsis
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Loivamaeki, M.; Louis, S.; Cinege, G.; Zimmer, I.; Fischbach, R.J.; Schnitzler, J.P.
Circadian rhythms of isoprene biosynthesis in grey poplar leaves
Plant Physiol.
143
540-551
2007
BRENDA: Populus tremula x Populus alba (Q7XAS7)
Textmining: Populus, Arabidopsis
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Loivamaeki, M.; Gilmer, F.; Fischbach, R.J.; Soergel, C.; Bachl, A.; Walter, A.; Schnitzler, J.P.
Arabidopsis, a model to study biological functions of isoprene emission?
Plant Physiol.
144
1066-1078
2007
BRENDA: Arabidopsis thaliana
Textmining: Arabidopsis, Populus, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Vickers, C.E.; Possell, M.; Cojocariu, C.I.; Velikova, V.B.; Laothawornkitkul, J.; Ryan, A.; Mullineaux, P.M.; Hewitt, C.N.
isoprene synthesis protects transgenic tobacco plants from oxidative stress
Plant Cell Environ.
32
520-531
2009
Populus alba (A9Q7C9)
Manually annotated by BRENDA team
Fortunati, A.; Barta, C.; Brilli, F.; Centritto, M.; Zimmer, I.; Schnitzler, J.P.; Loreto, F.
Isoprene emission is not temperature-dependent during and after severe drought-stress: a physiological and biochemical analysis
Plant J.
55
687-697
2008
Populus nigra (A0PFK2), Populus nigra
Manually annotated by BRENDA team
Rasulov, B.; Copolovici, L.; Laisk, A.; Niinemets, U.
Postillumination isoprene emission: in vivo measurements of dimethylallyldiphosphate pool size and isoprene synthase kinetics in aspen leaves
Plant Physiol.
149
1609-1618
2009
BRENDA: Populus tremula x Populus tremuloides
Textmining: Populus, Tremula
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Lindberg, P.; Park, S.; Melis, A.
Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism
Metab. Eng.
12
70-79
2010
BRENDA: Pueraria montana var. lobata (Q6EJ97), Pueraria montana var. lobata
Textmining: Cyanobacteria, Synechocystis, Pueraria montana
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Wiberley, A.E.; Donohue, A.R.; Westphal, M.M.; Sharkey, T.D.
Regulation of isoprene emission from poplar leaves throughout a day
Plant Cell Environ.
32
939-947
2009
Populus trichocarpa
Manually annotated by BRENDA team
Vickers, C.E.; Possell, M.; Nicholas Hewitt, C.; Mullineaux, P.M.
Genetic structure and regulation of isoprene synthase in Poplar (Populus spp.)
Plant Mol. Biol.
73
547-558
2010
BRENDA: Populus alba (D8UY75), Populus alba (D8UY76), Populus alba
Textmining: Populus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Rasulov, B.; Hueve, K.; Vaelbe, M.; Laisk, A.; Niinemets, U.
Evidence that light, carbon dioxide, and oxygen dependencies of leaf isoprene emission are driven by energy status in hybrid aspen
Plant Physiol.
151
448-460
2009
Populus tremula x Populus tremuloides
Manually annotated by BRENDA team
Zhao, Y.; Yang, J.; Qin, B.; Li, Y.; Sun, Y.; Su, S.; Xian, M.
Biosynthesis of isoprene in Escherichia coli via methylerythritol phosphate (MEP) pathway
Appl. Microbiol. Biotechnol.
90
1915-1922
2011
BRENDA: Populus nigra (A0PFK2), Populus nigra
Textmining: Escherichia coli
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Koeksal, M.; Zimmer, I.; Schnitzler, J.P.; Christianson, D.W.
Structure of isoprene synthase illuminates the chemical mechanism of teragram atmospheric carbon emission
J. Mol. Biol.
402
363-373
2010
Populus tremula x Populus alba (Q9AR86), Populus tremula x Populus alba
Manually annotated by BRENDA team
Vickers, C.E.; Possell, M.; Laothawornkitkul, J.; Ryan, A.C.; Hewitt, C.N.; Mullineaux, P.M.
Isoprene synthesis in plants: lessons from a transgenic tobacco model
Plant Cell Environ.
34
1043-1053
2011
BRENDA: Populus alba (D8UY76)
Textmining: Nicotiana tabacum, Populus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Rasulov, B.; Hueve, K.; Bichele, I.; Laisk, A.; Niinemets, U.
Temperature response of isoprene emission in vivo reflects a combined effect of substrate limitations and isoprene synthase activity: a kinetic analysis
Plant Physiol.
154
1558-1570
2010
Populus sp.
Manually annotated by BRENDA team
Li, Z.; Ratliff, E.A.; Sharkey, T.D.
Effect of temperature on postillumination isoprene emission in oak and poplar
Plant Physiol.
155
1037-1046
2011
Quercus robur
Manually annotated by BRENDA team
Zhou, C.; Li, Z.; Wiberley-Bradford, A.E.; Weise, S.E.; Sharkey, T.D.
Isopentenyl diphosphate and dimethylallyl diphosphate/isopentenyl diphosphate ratio measured with recombinant isopentenyl diphosphate isomerase and isoprene synthase
Anal. Biochem.
440
130-136
2013
Eucalyptus sp.
Manually annotated by BRENDA team
Bentley, F.K.; Zurbriggen, A.; Melis, A.
Heterologous expression of the mevalonic acid pathway in cyanobacteria enhances endogenous carbon partitioning to isoprene
Mol. plant
7
71-86
2014
BRENDA: Pueraria montana (Q6EJ97)
Textmining: Cyanobacteria, Synechocystis sp., Modified Vaccinia Ankara virus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Yang, J.; Xian, M.; Su, S.; Zhao, G.; Nie, Q.; Jiang, X.; Zheng, Y.; Liu, W.
Enhancing production of bio-isoprene using hybrid MVA pathway and isoprene synthase in E. coli
PLoS ONE
7
e33509
2012
BRENDA: Populus alba (Q50L36), Populus alba
Textmining: Modified Vaccinia Ankara virus
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Yeom, S.J.; Kim, M.; Kim, S.K.; Lee, D.H.; Kwon, K.K.; Lee, H.; Kim, H.; Kim, D.M.; Lee, S.G.
Molecular and biochemical characterization of a novel isoprene synthase from Metrosideros polymorpha
BMC Plant Biol.
18
118
2018
Metrosideros polymorpha
Manually annotated by BRENDA team
Li, M.; Liu, C.; Chen, H.; Deng, L.; Zhang, H.; Nian, R.; Xian, M.
Biochemical characterization of isoprene synthase from Ipomoea batatas
J. Biosci. Bioeng.
127
138-144
2019
Ipomoea batatas, Populus alba
Manually annotated by BRENDA team
Rossi, L.; Borghi, M.; Yang, J.; Xie, D.Y.
Overexpression of Populus x canescens isoprene synthase gene in Camelina sativa leads to alterations in its growth and metabolism
J. Plant Physiol.
215
122-131
2017
BRENDA: Populus tremula x Populus alba (Q9AR86), Populus tremula x Populus alba
Textmining: Camelina sativa, Camelina, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Wang, F.; Lv, X.; Xie, W.; Zhou, P.; Zhu, Y.; Yao, Z.; Yang, C.; Yang, X.; Ye, L.; Yu, H.
Combining Gal4p-mediated expression enhancement and directed evolution of isoprene synthase to improve isoprene production in Saccharomyces cerevisiae
Metab. Eng.
39
257-266
2017
BRENDA: Populus alba
Textmining: Saccharomyces cerevisiae, plant
Manually annotated by BRENDA teamAutomatic Mining of ENzyme DAta
Chaves, J.E.; Romero, P.R.; Kirst, H.; Melis, A.
Role of isopentenyl-diphosphate isomerase in heterologous cyanobacterial (Synechocystis) isoprene production
Photosynth. Res.
130
517-527
2016
Cyanobacteria
Automatic Mining of ENzyme DAta
Lantz, A.T.; Cardiello, J.F.; Gee, T.A.; Richards, M.G.; Rosenstiel, T.N.; Fisher, A.J.
Biochemical characterization of an isoprene synthase from Campylopus introflexus (heath star moss)
Plant Physiol. Biochem.
94
209-215
2015
Campylopus introflexus
Manually annotated by BRENDA team
Yang, J; Zhao, G; Sun, Y; Zheng, Y; Jiang, X; Liu, W; Xian, M
Bio-isoprene production using exogenous MVA pathway and isoprene synthase in Escherichia coli.
Bioresour Technol
104
642-7
2012
Escherichia coli, Modified Vaccinia Ankara virus, Saccharomyces cerevisiae, Populus alba, Escherichia coli BL21(DE3)
Automatic Mining of ENzyme DAta
Gomaa, L; Loscar, ME; Zein, HS; Abdel-Ghaffar, N; Abdelhadi, AA; Abdelaal, AS; Abdallah, NA
Boosting isoprene production via heterologous expression of the Kudzu isoprene synthase gene (kIspS) into Bacillus spp. cell factory.
AMB Express
7
161
2017
Bacillus, Bacillus subtilis ATCC 33234, Bacteria, Metazoa, Pueraria montana var. lobata
Automatic Mining of ENzyme DAta
Chaves, JE; Rueda-Romero, P; Kirst, H; Melis, A
Engineering Isoprene Synthase Expression and Activity in Cyanobacteria.
ACS Synth Biol
2017
Cyanobacteria
Automatic Mining of ENzyme DAta
Barta, CE; Bolander, B; Bilby, SR; Brown, JH; Brown, RN; Duryee, AM; Edelman, DR; Gray, CE; Gossett, C; Haddock, AG; Helsel, MM; Jones, AD; Klingseis, ME; Leslie, K; Miles, EW; Prawitz, RA
In Situ Dark Adaptation Enhances the Efficiency of DNA Extraction from Mature Pin Oak (Quercus palustris) Leaves, Facilitating the Identification of Partial Sequences of the 18S rRNA and Isoprene Synthase (IspS) Genes.
Plants (Basel)
6
2017
Quercus palustris
Automatic Mining of ENzyme DAta
Yao, Z; Zhou, P; Su, B; Su, S; Ye, L; Yu, H
Enhanced Isoprene Production by Reconstruction of Metabolic Balance between Strengthened Precursor Supply and Improved Isoprene Synthase in Saccharomyces cerevisiae.
ACS Synth Biol
7
2308-2316
2018
Saccharomyces cerevisiae
Automatic Mining of ENzyme DAta
Janke, C; Gaida, S; Jennewein, S
The production of isoprene from cellulose using recombinant Clostridium cellulolyticum strains expressing isoprene synthase.
Microbiologyopen
e1008
2020
Ruminiclostridium cellulolyticum, Populus
Automatic Mining of ENzyme DAta
Liu, CL; Bi, HR; Bai, Z; Fan, LH; Tan, TW
Engineering and manipulation of a mevalonate pathway in Escherichia coli for isoprene production.
Appl Microbiol Biotechnol
103
239-250
2019
Populus alba
Automatic Mining of ENzyme DAta
Oku, H; Inafuku, M; Ishikawa, T; Takamine, T; Ishmael, M; Fukuta, M
Molecular cloning and biochemical characterization of isoprene synthases from the tropical trees Ficus virgata, Ficus septica, and Casuarina equisetifolia.
J Plant Res
128
849-61
2015
Casuarina, Populus alba, Ferrisia virgata
Automatic Mining of ENzyme DAta
Lv, X; Xu, H; Yu, H
Significantly enhanced production of isoprene by ordered coexpression of genes dxs, dxr, and idi in Escherichia coli.
Appl Microbiol Biotechnol
97
2357-65
2013
Escherichia coli, Populus alba
Automatic Mining of ENzyme DAta
Mutanda, I; Inafuku, M; Saitoh, S; Iwasaki, H; Fukuta, M; Watanabe, K; Oku, H
Temperature controls on the basal emission rate of isoprene in a tropical tree Ficus septica: exploring molecular regulatory mechanisms.
Plant Cell Environ
39
2260-75
2016
Ficus septica
Automatic Mining of ENzyme DAta
Sharkey, TD; Yeh, S; Wiberley, AE; Falbel, TG; Gong, D; Fernandez, DE
Evolution of the isoprene biosynthetic pathway in kudzu.
Plant Physiol
137
700-12
2005
Pueraria montana var. lobata, Arabidopsis, plant
Automatic Mining of ENzyme DAta
Behnke, K; Ehlting, B; Teuber, M; Bauerfeind, M; Louis, S; Hänsch, R; Polle, A; Bohlmann, J; Schnitzler, JP
Transgenic, non-isoprene emitting poplars don't like it hot.
Plant J
51
485-99
2007
Populus
Automatic Mining of ENzyme DAta
Ilmn, M; Oja, M; Huuskonen, A; Lee, S; Ruohonen, L; Jung, S
Identification of novel isoprene synthases through genome mining and expression in Escherichia coli.
Metab Eng
31
153-62
2015
Ipomoea batatas, Populus alba, Pueraria montana
Automatic Mining of ENzyme DAta
Pade, N; Erdmann, S; Enke, H; Dethloff, F; Dhring, U; Georg, J; Wambutt, J; Kopka, J; Hess, WR; Zimmermann, R; Kramer, D; Hagemann, M
Insights into isoprene production using the cyanobacterium Synechocystis sp. PCC 6803.
Biotechnol Biofuels
9
89
2016
Synechocystis, plant
Automatic Mining of ENzyme DAta
Kim, JH; Wang, C; Jang, HJ; Cha, MS; Park, JE; Jo, SY; Choi, ES; Kim, SW
Isoprene production by Escherichia coli through the exogenous mevalonate pathway with reduced formation of fermentation byproducts.
Microb Cell Fact
15
214
2016
Populus trichocarpa, Escherichia coli str. K-12 substr. MG1655
Automatic Mining of ENzyme DAta
Zuo, Z; Weraduwage, SM; Lantz, AT; Sanchez, LM; Weise, SE; Wang, J; Childs, K; Sharkey, TD
Isoprene Acts as a Signaling Molecule in Gene Networks Important for Stress Responses and Plant Growth.
Plant Physiol
2019
Arabidopsis, Eucalyptus globulus
Automatic Mining of ENzyme DAta
Aldridge, J; Carr, S; Weber, KA; Buan, NR
Anaerobic Production of Isoprene by Engineered Methanosarcina Species Archaea.
Appl Environ Microbiol
87
2021
Electron
Automatic Mining of ENzyme DAta
Ghirardo, A; Nosenko, T; Kreuzwieser, J; Winkler, JB; Kruse, J; Albert, A; Merl-Pham, J; Lux, T; Ache, P; Zimmer, I; Alfarraj, S; Mayer, KFX; Hedrich, R; Rennenberg, H; Schnitzler, JP
Protein expression plasticity contributes to heat and drought tolerance of date palm.
Oecologia
2021
Phoenix dactylifera
Automatic Mining of ENzyme DAta
Cinege, G; Louis, S; Hänsch, R; Schnitzler, JP
Regulation of isoprene synthase promoter by environmental and internal factors.
Plant Mol Biol
69
593-604
2009
Populus, Arabidopsis thaliana, plant
Automatic Mining of ENzyme DAta
Sharkey, TD; Gray, DW; Pell, HK; Breneman, SR; Topper, L
Isoprene synthase genes form a monophyletic clade of acyclic terpene synthases in the TPS-B terpene synthase family.
Evolution
67
1026-40
2013
Magnoliopsida
Automatic Mining of ENzyme DAta
Liu, CL; Cai, JY; Bi, HR; Tan, TW
A novel DMAPP-responding genetic circuit sensor for high-throughput screening and evolving isoprene synthase.
Appl Microbiol Biotechnol
102
1381-1391
2018
Escherichia coli
Automatic Mining of ENzyme DAta
Xu, J; Trainotti, L; Li, M; Varotto, C
Overexpression of Isoprene Synthase Affects ABA- and Drought-Related Gene Expression and Enhances Tolerance to Abiotic Stress.
Int J Mol Sci
21
2020
Arabidopsis
Automatic Mining of ENzyme DAta
Volke, DC; Rohwer, J; Fischer, R; Jennewein, S
Investigation of the methylerythritol 4-phosphate pathway for microbial terpenoid production through metabolic control analysis.
Microb Cell Fact
18
192
2019
Escherichia coli
Automatic Mining of ENzyme DAta
Miloradovic van Doorn, M; Merl-Pham, J; Ghirardo, A; Fink, S; Polle, A; Schnitzler, JP; Rosenkranz, M
Root isoprene formation alters lateral root development.
Plant Cell Environ
2020
Populus, Populus tremula x Populus alba
Automatic Mining of ENzyme DAta
Niinemets, ; Sun, Z; Talts, E
Controls of the quantum yield and saturation light of isoprene emission in different-aged aspen leaves.
Plant Cell Environ
38
2707-20
2015
Tremula
Automatic Mining of ENzyme DAta
Bentley, FK; Melis, A
Diffusion-based process for carbon dioxide uptake and isoprene emission in gaseous/aqueous two-phase photobioreactors by photosynthetic microorganisms.
Biotechnol Bioeng
2011
Pueraria montana
Automatic Mining of ENzyme DAta
Li, M; Xu, J; Algarra Alarcon, A; Carlin, S; Barbaro, E; Cappellin, L; Velikova, V; Vrhovsek, U; Loreto, F; Varotto, C
In Planta Recapitulation of Isoprene Synthases Evolution from Ocimene Synthases.
Mol Biol Evol
2017
Magnoliopsida, Arabidopsis, Donax
Automatic Mining of ENzyme DAta
Li, M; Cappellin, L; Xu, J; Biasioli, F; Varotto, C
High-throughput screening for in planta characterization of VOC biosynthetic genes by PTR-ToF-MS.
J Plant Res
133
123-131
2020
Arabidopsis thaliana
Automatic Mining of ENzyme DAta