Reference on EC 4.2.3.24 - amorpha-4,11-diene synthase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mercke, P.; Bengtsson, M.; Bouwmeester, H.J.; Posthumus, M.A.; Brodelius, P.E.
Molecular cloning, expression, and characterization of amorpha-4,11-diene synthase, a key enzyme of artemisinin biosynthesis in Artemisia annua L.
Arch. Biochem. Biophys.
381
173-180
2000
Artemisia annua
Chang, Y.J.; Song, S.H.; Park, S.H.; Kim, S.U.
Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis
Arch. Biochem. Biophys.
383
178-184
2000
Artemisia annua (Q9AR04), Artemisia annua
Picaud, S.; Olofsson, L.; Brodelius, M.; Brodelius, P.E.
Expression, purification, and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L
Arch. Biochem. Biophys.
436
215-226
2005
BRENDA: Artemisia annua
Textmining: Escherichia coli
Picaud, S.; Mercke, P.; He, X.; Sterner, O.; Brodelius, M.; Cane, D.E.; Brodelius, P.E.
Amorpha-4,11-diene synthase: mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate
Arch. Biochem. Biophys.
448
150-155
2006
BRENDA: Artemisia annua
Textmining: Escherichia coli
Kim, S.H.; Heo, K.; Chang, Y.J.; Park, S.H.; Rhee, S.K.; Kim, S.U.
Cyclization mechanism of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis
J. Nat. Prod.
69
758-762
2006
Artemisia annua
Martin, V.J.; Pitera, D.J.; Withers, S.T.; Newman, J.D.; Keasling, J.D.
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
Nat. Biotechnol.
21
796-802
2003
BRENDA: Artemisia annua
Textmining: Escherichia coli, Saccharomyces cerevisiae
Bouwmeester, H.J.; Wallaart, T.E.; Janssen, M.H.A.; Van Loo, B.; Jansen, B.J.M.; Posthumus, M.A.; Schmidt, C.O.; De Kraker, J.W.; Konig, W.A.; Franssen, M.C.R.
Amorpha-4,11-diene synthase catalyzes the first probable step in artemisinin biosynthesis
Phytochemistry
52
843-854
1999
Artemisia annua
Wallaart, T.E.; Bouwmeester, H.J.; Hille, J.; Poppinga, L.; Maijers, N.C.A.
Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
Planta
212
460-465
2001
Artemisia annua (Q9AR04), Artemisia annua
Lindahl, A.L.; Olsson, M.E.; Mercke, P.; Tollbom, O.; Schelin, J.; Brodelius, M.; Brodelius, P.E.
Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae
Biotechnol. Lett.
28
571-580
2006
BRENDA: Artemisia annua (Q9AR04), Artemisia annua
Textmining: Saccharomyces cerevisiae
Li, Z.; Liu, Y.; Liu, B.; Wang, H.; Ye, H.; Li, G.
Cloning, E. coli expression and molecular analysis of amorpha-4,11-diene synthase from a high-yield strain of Artemisia annua L
J. Integr. Plant Biol.
48
1486-1492
2006
Artemisia annua
-
Kim, S.H.; Chang, Y.J.; Kim, S.U.
Tissue specificity and developmental pattern of amorpha-4,11-diene synthase (ADS) proved by ADS promoter-driven GUS expression in the heterologous plant, Arabidopsis thaliana
Planta Med.
74
188-193
2008
BRENDA: Artemisia annua
Textmining: Arabidopsis thaliana, plant
Picaud, S.; Olsson, M.E.; Brodelius, P.E.
Improved conditions for production of recombinant plant sesquiterpene synthases in Escherichia coli
Protein Expr. Purif.
51
71-79
2007
BRENDA: Artemisia annua (Q9AR04), Artemisia annua
Textmining: Escherichia coli, Zingiber officinale, Zingiber officinale (Q0VHD6)
Jiang-Qiang, K.; Wei, W.; Li-Na, W.; Xiao-Dong, Z.; Ke-Di, C.; Ping, Z.
The improvement of amorpha-4,11-diene production by a yeast-conform variant
J. Appl. Microbiol.
106
941-951
2009
BRENDA: Artemisia annua (Q9AR04), Artemisia annua
Textmining: Saccharomyces cerevisiae
Lubertozzi, D.; Keasling, J.D.
Expression of a synthetic Artemesia annua amorphadiene synthase in Aspergillus nidulans yields altered product distribution
J. Ind. Microbiol. Biotechnol.
35
1191-1198
2008
BRENDA: Artemisia annua
Textmining: Aspergillus nidulans, plant
Anthony, J.R.; Anthony, L.C.; Nowroozi, F.; Kwon, G.; Newman, J.D.; Keasling, J.D.
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene
Metab. Eng.
11
13-19
2008
BRENDA: Artemisia annua
Textmining: Escherichia coli
Olsson, M.E.; Olofsson, L.M.; Lindahl, A.L.; Lundgren, A.; Brodelius, M.; Brodelius, P.E.
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L
Phytochemistry
70
1123-1128
2009
Artemisia annua
Ma, D.; Pu, G.; Lei, C.; Ma, L.; Wang, H.; Guo, Y.; Chen, J.; Du, Z.; Wang, H.; Li, G.; Ye, H.; Liu, B.
Isolation and characterization of AaWRKY1, an Artemisia annua transcription factor that regulates the amorpha-4,11-diene synthase gene, a key gene of artemisinin biosynthesis
Plant Cell Physiol.
50
2146-2161
2009
Artemisia annua
Pu, G.B.; Ma, D.M.; Chen, J.L.; Ma, L.Q.; Wang, H.; Li, G.F.; Ye, H.C.; Liu, B.Y.
Salicylic acid activates artemisinin biosynthesis in Artemisia annua L
Plant Cell Rep.
28
1127-1135
2009
Artemisia annua
Farhi, M.; Marhevka, E.; Masci, T.; Marcos, E.; Eyal, Y.; Ovadis, M.; Abeliovich, H.; Vainstein, A.
Harnessing yeast subcellular compartments for the production of plant terpenoids
Metab. Eng.
13
474-481
2011
Saccharomyces cerevisiae
Alam, P.; Kiran, U.; Ahmad, M.M.; Kamaluddin, M.M.; Khan, M.A.; Jhanwar, S.; Abdin, M.
Isolation, characterization and structural studies of amorpha - 4, 11-diene synthase (ADS(3963)) from Artemisia annua L
Bioinformation
4
421-429
2010
Artemisia annua (Q9AR04), Artemisia annua
Alam, P.; Abdin, M.Z.
Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content
Plant Cell Rep.
30
1919-1928
2011
Artemisia annua (C5HG79), Artemisia annua, Artemisia annua L. (C5HG79)
Alejos-Gonzalez, F.; Qu, G.; Zhou, L.L.; Saravitz, C.H.; Shurtleff, J.L.; Xie, D.Y.
Characterization of development and artemisinin biosynthesis in self-pollinated Artemisia annua plants
Planta
234
685-697
2011
Artemisia annua
Zhang, Y.; Nowak, G.; Reed, D.W.; Covello, P.S.
The production of artemisinin precursors in tobacco
Plant Biotechnol. J.
9
445-454
2011
Artemisia annua, Nicotiana tabacum, Artemisia annua (C5H429)
Pu, G.; Ma, D.; Wang, H.; Ye, H.; Liu, B.
Expression and localization of amorpha-4,11-diene synthase in Artemisia annua L.
Plant Mol. Biol. Rep.
31
32-37
2013
Artemisia annua
-
Ji, Y.; Xiao, J.; Shen, Y.; Ma, D.; Li, Z.; Pu, G.; Li, X.; Huang, L.; Liu, B.; Ye, H.; Wang, H.
Cloning and characterization of AabHLH1, a bHLH transcription factor that positively regulates artemisinin biosynthesis in Artemisia annua
Plant Cell Physiol.
55
1592-1604
2014
Artemisia annua, Artemisia annua (Q1PS23)
Muangphrom, P.; Seki, H.; Suzuki, M.; Komori, A.; Nishiwaki, M.; Mikawa, R.; Fukushima, E.O.; Muranaka, T.
Functional analysis of amorpha-4,11-diene synthase (ADS) homologs from non-artemisinin-producing artemisia species the discovery of novel koidzumiol and (+)-alpha-bisabolol synthases
Plant Cell Physiol.
57
1678-1688
2016
BRENDA: Artemisia annua (Q9AR04), Artemisia annua
Textmining: Artemisia
Chen, X.; Zhang, C.; Zou, R.; Stephanopoulos, G.; Too, H.P.
In vitro metabolic engineering of amorpha-4,11-diene biosynthesis at enhanced rate and specific yield of production
ACS Synth. Biol.
6
1691-1700
2017
Artemisia annua
Fang, X.; Li, J.X.; Huang, J.Q.; Xiao, Y.L.; Zhang, P.; Chen, X.Y.
Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase
Biochem. J.
474
2191-2202
2017
Artemisia annua
Li, Z.; Gao, R.; Hao, Q.; Zhao, H.; Cheng, L.; He, F.; Liu, L.; Liu, X.; Chou, W.K.; Zhu, H.; Cane, D.E.
The T296V mutant of amorpha-4,11-diene synthase is defective in allylic diphosphate isomerization but retains the ability to cyclize the intermediate (3R)-nerolidyl diphosphate to amorpha-4,11-diene
Biochemistry
55
6599-6604
2016
Artemisia annua (Q9AR04)
Catania, T.M.; Branigan, C.A.; Stawniak, N.; Hodson, J.; Harvey, D.; Larson, T.R.; Czechowski, T.; Graham, I.A.
Silencing amorpha-4,11-diene synthase genes in Artemisia annua leads to FPP accumulation
Front. Plant Sci.
9
547
2018
Artemisia annua
Eslami, H.; Mohtashami, S.K.; Basmanj, M.T.; Rahati, M.; Rahimi, H.
An in-silico insight into the substrate binding characteristics of the active site of amorpha-4,11-diene synthase, a key enzyme in artemisinin biosynthesis
J. Mol. Model.
23
202
2017
Artemisia annua (A2TEY7), Artemisia annua
Abdallah, I.I.; Czepnik, M.; van Merkerk, R.; Quax, W.J.
Insights into the three-dimensional structure of amorpha-4,11-diene synthase and probing of plasticity residues
J. Nat. Prod.
79
2455-2463
2016
Artemisia annua
Abdallah, I.I.; van Merkerk, R.; Klumpenaar, E.; Quax, W.J.
Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering
Sci. Rep.
8
9961
2018
Artemisia annua (Q9AR04)
Kong, JQ; Cheng, KD; Wang, LN; Zheng, XD; Dai, JG; Zhu, P; Wang, W
[Increase of copy number of HMG-CoA reductase and FPP synthase genes improves the amorpha4,11-diene production in engineered yeast]
Yao Xue Xue Bao
42
1314-9
2007
Koobkokkruad, T; Chochai, A; Kirdmanee, C; De-Eknamkul, W
Effects of low-dose gamma irradiation on artemisinin content and amorpha-4,11-diene synthase activity in Artemisia annua L.
Int J Radiat Biol
84
878-84
2008
Artemisia annua
Kong, J; Zhi, X; Wang, W; Cheng, K; Zhu, P
[Synergistic effect of amorpha-4,11-diene synthase gene in engineered Saccharomyces cerevisiae].
Sheng Wu Gong Cheng Xue Bao
27
196-202
2011
Saccharomyces
Elfahmi, E; Cahyani, FM; Kristianti, T; Suhandono, S
Transformation of Amorphadiene Synthase and Antisilencing P19 Genes into Artemisia annua L. and its Effect on Antimalarial Artemisinin Production.
Adv Pharm Bull
10
464-471
2020
Artemisia annua, Transformation
Czechowski, T; Rinaldi, MA; Famodimu, MT; Van Veelen, M; Larson, TR; Winzer, T; Rathbone, DA; Harvey, D; Horrocks, P; Graham, IA
Flavonoid Versus Artemisinin Anti-malarial Activity in Artemisia annua Whole-Leaf Extracts.
Front Plant Sci
10
984
2019
Artemisia annua
Kwak, S; Yun, EJ; Lane, S; Oh, EJ; Kim, KH; Jin, YS
Redirection of the Glycolytic Flux Enhances Isoprenoid Production in Saccharomyces cerevisiae.
Biotechnol J
e1900173
2019
Saccharomyces cerevisiae
Yang, RY; Feng, LL; Yang, XQ; Yin, LL; Xu, XL; Zeng, QP
Quantitative Transcript Profiling Reveals Down-Regulation of A Sterol Pathway Relevant Gene and Overexpression of Artemisinin Biogenetic Genes in Transgenic Artemisia annua Plants.
Planta Med
74
1510-6
2008
Artemisia annua
Ro, DK; Ouellet, M; Paradise, EM; Burd, H; Eng, D; Paddon, CJ; Newman, JD; Keasling, JD
Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid.
BMC Biotechnol
8
83
2008
plant
Firsov, A; Mitiouchkina, T; Shaloiko, L; Pushin, A; Vainstein, A; Dolgov, S
Agrobacterium-Mediated Transformation of Chrysanthemum with Artemisinin Biosynthesis Pathway Genes.
Plants (Basel)
9
2020
Chrysanthemum, Agrobacterium tumefaciens, Saccharomyces cerevisiae, Artemisia annua
Ro, DK; Paradise, EM; Ouellet, M; Fisher, KJ; Newman, KL; Ndungu, JM; Ho, KA; Eachus, RA; Ham, TS; Kirby, J; Chang, MC; Withers, ST; Shiba, Y; Sarpong, R; Keasling, JD
Production of the antimalarial drug precursor artemisinic acid in engineered yeast.
Nature
440
940-3
2006
Saccharomyces cerevisiae, Artemisia annua
Kwak, S; Kim, SR; Xu, H; Zhang, GC; Lane, S; Kim, H; Jin, YS
Enhanced isoprenoid production from xylose by engineered Saccharomyces cerevisiae.
Biotechnol Bioeng
2017
Saccharomyces cerevisiae
Wu, T; Wu, S; Yin, Q; Dai, H; Li, S; Dong, F; Chen, B; Fang, H
[Biosynthesis of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli through introducing mevalonate pathway].
Sheng Wu Gong Cheng Xue Bao
27
1040-8
2011
Escherichia coli, Enterococcus faecalis
Choi, SY; Lee, HJ; Choi, J; Kim, J; Sim, SJ; Um, Y; Kim, Y; Lee, TS; Keasling, JD; Woo, HM
Photosynthetic conversion of CO2 to farnesyl diphosphate-derived phytochemicals (amorpha-4,11-diene and squalene) by engineered cyanobacteria.
Biotechnol Biofuels
9
202
2016
Synechococcus elongatus PCC 7942 = FACHB-805
Mishra, S; Pandey, P; Dubey, AP; Zehra, A; Chanotiya, CS; Tripathi, AK; Mishra, MN
Engineering a Carotenoid-Overproducing Strain of Azospirillum brasilense for Heterologous Production of Geraniol and Amorphadiene.
Appl Environ Microbiol
86
2020
Azospirillum brasilense, Catharanthus roseus, Artemisia annua
Li, JX; Fang, X; Zhao, Q; Ruan, JX; Yang, CQ; Wang, LJ; Miller, DJ; Faraldos, JA; Allemann, RK; Chen, XY; Zhang, P
Rational engineering plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency.
Biochem J
2013
Artemisia annua
Wang, H; Han, J; Kanagarajan, S; Lundgren, A; Brodelius, PE
Studies on the expression of sesquiterpene synthases using promoter-?-glucuronidase fusions in transgenic Artemisia annua L.
PLoS One
8
e80643
2013
Artemisia annua
Withers, ST; Gottlieb, SS; Lieu, B; Newman, JD; Keasling, JD
Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity.
Appl Environ Microbiol
73
6277-83
2007
Escherichia coli
Baadhe, RR; Mekala, NK; Palagiri, SR; Parcha, SR
Development of Petri Net-Based Dynamic Model for Improved Production of Farnesyl Pyrophosphate by Integrating Mevalonate and Methylerythritol Phosphate Pathways in Yeast.
Appl Biochem Biotechnol
2012
Mink enteritis virus
Kanagarajan, S; Muthusamy, S; Gliszczy?ska, A; Lundgren, A; Brodelius, PE
Functional expression and characterization of sesquiterpene synthases from Artemisia annua L. using transient expression system in Nicotiana benthamiana.
Plant Cell Rep
31
1309-19
2012
Vigna unguiculata
Baadhe, RR; Mekala, NK; Parcha, SR; Prameela Devi, Y
Combination of ERG9 Repression and Enzyme Fusion Technology for Improved Production of Amorphadiene in Saccharomyces cerevisiae.
J Anal Methods Chem
2013
140469
2013
plant, Saccharomyces cerevisiae
Zhang, F; Fu, X; Lv, Z; Lu, X; Shen, Q; Zhang, L; Zhu, M; Wang, G; Sun, X; Liao, Z; Tang, K
A basic leucine zipper transcription factor, AabZIP1, connects abscisic acid signaling with artemisinin biosynthesis in Artemisia annua.
Mol Plant
8
163-75
2015
Saccharomyces cerevisiae
Elfahmi, ; Hapsari, RA; Chrysanthy, T; Synthiarini, V; Masduki, FF; Setiawan, A; Muranaka, T
Expression of Two Key Enzymes of Artemisinin Biosynthesis FPS and ADS genes in Saccharomyces cerevisiae.
Adv Pharm Bull
11
181-187
2021
Saccharomyces cerevisiae
Loizzi, M; Miller, DJ; Allemann, RK
Silent catalytic promiscuity in the high-fidelity terpene cyclase ?-cadinene synthase.
Org Biomol Chem
17
1206-1214
2019
Penicillium roqueforti
Demiray, M; Tang, X; Wirth, T; Faraldos, JA; Allemann, RK
An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde.
Angew Chem Int Ed Engl
56
4347-4350
2017
plant
Kobayashi, K; Kobayashi, K; Yamaguchi, H; Miyagi Inoue, Y; Takagi, K; Fushihara, K; Seki, H; Suzuki, M; Nagata, N; Muranaka, T
Platform for "Chemical Metabolic Switching" to Increase Sesquiterpene Content in Plants.
Plant Biotechnol (Tokyo)
34
65-69
2017
Arabidopsis
html completed
