Information on EC 4.2.3.22 - germacradienol synthase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
4.2.3.22
-
RECOMMENDED NAME
GeneOntology No.
germacradienol synthase
PATHWAY
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
-
geosmin biosynthesis
-
Metabolic pathways
-
Sesquiterpenoid and triterpenoid biosynthesis
-
SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]
Requires Mg2+ for activity. H-1si of farnesyl diphosphate is lost in the formation of (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol. Formation of (-)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si of farnesyl diphosphate. Both products are formed from a common intermediate [2]. Other enzymes produce germacrene D as the sole product using a different mechanism. The enzyme mediates a key step in the biosynthesis of geosmin (see EC 4.1.99.16 geosmin synthase), a widely occurring metabolite of many streptomycetes, bacteria and fungi [2]. Also catalyses the reaction of EC 4.2.3.75, (-)-germacrene D synthase.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Cyc2
Q9X839
gene name
germacradienol synthase
-
-
germacradienol synthase
B0FLN6
-
germacradienol/geosmin synthase
-
-
germacradienol/germacrene D synthase
Q82L49
-
germacradienol/germacrene D synthase
Q9X839
-
germacradienol/germacrene D synthase
-
-
germacrene D synthase
Q49SP6
-
sesquiterpene synthase
-
-
sesquiterpene synthase
-
-
spterp13
B0FLN6
-
CAS REGISTRY NUMBER
COMMENTARY
211049-88-6
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
germacradienol/germacrene D synthase
UniProt
Manually annotated by BRENDA team
several strains, gene cyc2 or Sco6073 encoding an enzyme with two sesquiterpene synthase domains
-
-
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
SOURCE
B0FLN6
strain ATCC 27952 produces clinically important anthracycline chemotherapeutic agents of the polyketide class of antibiotics, daunorubicin and doxorubicin
Manually annotated by BRENDA team
MOLECULAR WEIGHT
MOLECULAR WEIGHT MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
83000
-
Q82L49, -
determined by SDS-PAGE
98000
-
B0FLN6
recombinant Spterp13, consistent with the predicted mass of Spterp13 plus his-tag determined by SDS-PAGE analysis