Information on EC 4.2.3.2 - ethanolamine-phosphate phospho-lyase

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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

EC NUMBER
COMMENTARY
4.2.3.2
-
RECOMMENDED NAME
GeneOntology No.
ethanolamine-phosphate phospho-lyase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate
show the reaction diagram
a pyridoxal-phosphate protein. Also acts on D(or L)-1-aminopropan-2-ol O-phosphate, A pyridoxal-phosphate protein.
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Glycerophospholipid metabolism
-
-
Metabolic pathways
-
-
SYSTEMATIC NAME
IUBMB Comments
ethanolamine-phosphate phosphate-lyase (deaminating; acetaldehyde-forming)
A pyridoxal-phosphate protein. Also acts on D(or L)-1-aminopropan-2-ol O-phosphate.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino alcohol O-phosphate phospholyase
-
-
-
-
O-phosphoethanolamine-phospholyase
-
-
-
-
O-phosphorylethanol-amine phospho-lyase
-
-
-
-
phospho-lyase, ethanolamine phosphate
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37290-88-3
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
NCIB 9205
-
-
Manually annotated by BRENDA team
Flavobacterium rhenanum
NCIB 9157
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ethanolamine phosphate
?
show the reaction diagram
-
role in deamination process necessary for N-assimilation
-
-
-
ethanolamine phosphate + H2O
acetaldehyde + NH3 + phosphate
show the reaction diagram
-
-
-
?
ethanolamine phosphate + H2O
acetaldehyde + NH3 + phosphate
show the reaction diagram
-
-
-
?
ethanolamine phosphate + H2O
acetaldehyde + NH3 + phosphate
show the reaction diagram
-
-
-
?
ethanolamine phosphate + H2O
acetaldehyde + NH3 + phosphate
show the reaction diagram
-
-
-
?
ethanolamine phosphate + H2O
acetaldehyde + NH3 + phosphate
show the reaction diagram
-
-
-
?
ethanolamine phosphate + H2O
acetaldehyde + NH3 + phosphate
show the reaction diagram
-
-
-
?
ethanolamine phosphate + H2O
acetaldehyde + NH3 + phosphate
show the reaction diagram
Flavobacterium rhenanum
-
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ethanolamine phosphate
?
show the reaction diagram
-
role in deamination process necessary for N-assimilation
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
pyridoxal 5'-phosphate
-
required, Km: 0.00027 mM
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ag+
-
0.1 mM, 92% inhibition
Cd2+
-
0.1 mM, 100% inhibition
CN-
-
1 mM, 88% inhibition
Co2+
-
0.1 mM, 25% inhibition
Cu2+
-
0.1 mM, 94% inhibition
hydroxylamine
-
-
p-chloromercuribenzoate
-
0.1 mM, 98.4% inhibition
Pb2+
-
0.1 mM, 75% inhibition
SO42-
-
10 mM, 49% inhibition
Zn2+
-
0.1 mM, 91% inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.28
Ethanolamine phosphate
-
-
0.32
Ethanolamine phosphate
Flavobacterium rhenanum
-
-
0.45
Ethanolamine phosphate
-
-
0.61
Ethanolamine phosphate
-
-
0.63
Ethanolamine phosphate
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.00014
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.7 - 8.6
-
less than 50% of maximal activity above and below
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
168000
-
gel filtration
137597
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE