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Reference on EC 4.2.3.19 - ent-kaurene synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fall, R.R.; West, C.A.
Purification and properties of kaurene synthetase from Fusarium moniliforme
J. Biol. Chem.
246
6913-6928
1971
Fusarium verticillioides
Manually annotated by BRENDA team
Yamaguchi, S.; Saito, T.; Abe, H.; Yamane, H.; Murofushi, N.; Kamiya, Y.
Molecular cloning and characterization of a cDNA encoding the gibberellin biosynthetic enzyme ent-kaurene synthase B from pumpkin (Cucurbita maxima L.)
Plant J.
10
203-213
1996
Cucurbita maxima
Manually annotated by BRENDA team
Kawaide, H.; Imai, R.; Sassa, T.; Kamiya, Y.
ent-Kaurene synthetase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis
J. Biol. Chem.
272
21706-21712
1997
Phaeosphaeria sp. (O13284), Phaeosphaeria sp., Phaeosphaeria sp. L487 (O13284)
Manually annotated by BRENDA team
Toyomasu, T.; Kawaide, H.; Ishizaki, A.; Shinoda, S.; Otsuka, M.; Mitsuhashi, W.; Sassa, T.
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase
Biosci. Biotechnol. Biochem.
64
660-664
2000
Fusarium fujikuroi (Q9UVY5), Fusarium fujikuroi
Manually annotated by BRENDA team
Frost, R.G.; West, C.A.
Properties of kaurene synthetase from Marah macrocarpus
Plant Physiol.
59
22-29
1977
Marah macrocarpa
Manually annotated by BRENDA team
Duncan, J.D.; West, C.A.
Properties of kaurene synthetase from Marah macrocarpus endosperm: evidence for the participation of separate but interacting enzymes
Plant Physiol.
68
1128-1134
1981
Marah macrocarpa
Manually annotated by BRENDA team
Shen-Miller, J.; West, C.A.
Kaurene synthetase activity in Helianthus annuus. Increases in enzyme activity after storage of seedlings in liquid nitrogen
Plant Physiol.
74
439-441
1984
Helianthus annuus, Marah macrocarpa
Manually annotated by BRENDA team
Shen-Miller, J.; West, C.A.
Distribution and ent-kaurene synthetase in Helianthus annuus and Marah macrocarpus
Phytochemistry
24
461-464
1985
Helianthus annuus, Marah macrocarpa
-
Manually annotated by BRENDA team
Aach, H.; Boese, G.; Graebe, J.E.
ent-Kaurene biosynthesis in a cell-free system from wheat (Triticum aestivum L.) seedlings and the localization of ent-kaurene synthetase in plastids of three species
Planta
197
333-342
1995
Cucurbita maxima, Pisum sativum, Triticum aestivum
-
Manually annotated by BRENDA team
Saito, T.; Abe, H.; Yamane, H.; Sakurai, A.; Murofushi, N.; Takio, K.; Takahashi, N.; Kamiya, Y.
Purification and properties of ent-kaurene synthase B from immature seeds of pumpkin
Plant Physiol.
109
1239-1245
1995
Cucurbita maxima
Manually annotated by BRENDA team
Saito, T.; Yamane, H.; Sakurai, A.; Murofushi, N.; Takahashi, N.; Kamiya, Y.
Inhibition of ent-kaurene synthase by quaternary ammonium growth retardants
Biosci. Biotechnol. Biochem.
60
1040-1042
1996
Cucurbita maxima, Fusarium fujikuroi
-
Manually annotated by BRENDA team
Aach, H.; Bode, H.; Robinson, D.G.; Graebe, J.E.
ent-Kaurene synthase is located in proplastids of meristematic shoot tissues
Planta
202
211-219
1997
Pisum sativum, Triticum aestivum
-
Manually annotated by BRENDA team
Kawaide, H.; Sassa, T.; Kamiya, Y.
Functional analysis of the two interacting cyclase domains in ent-kaurene synthase from the fungus Phaeosphaeria sp. L487 and a comparison with cyclases from higher plants
J. Biol. Chem.
275
2276-2280
2000
Phaeosphaeria sp. (O13284), Phaeosphaeria sp., Phaeosphaeria sp. L487 (O13284)
Manually annotated by BRENDA team
Sakamoto, T.; Miura, K.; Itoh, H.; Tatsumi, T.; Ueguchi-Tanaka, M.; Ishiyama, K.; Kobayashi, M.; Agrawal, G.K.; Takeda, S.; Abe, K.; Miyao, A.; Hirochika, H.; Kitano, H.; Ashikari, M.; Matsuoka, M.
An overview of gibberellin metabolism enzyme genes and their related mutants in rice
Plant Physiol.
134
1642-1653
2004
Oryza sativa
Manually annotated by BRENDA team
Fleet, C.M.; Yamaguchi, S.; Hanada, A.; Kawaide, H.; David, C.J.; Kamiya, Y.; Sun, T.P.
Overexpression of AtCPS and AtKS in Arabidopsis confers increased ent-kaurene production but no increase in bioactive gibberellins
Plant Physiol.
132
830-839
2003
Arabidopsis thaliana
Manually annotated by BRENDA team
Hayashi, K.; Kawaide, H.; Notomi, M.; Sakigi, Y.; Matsuo, A.; Nozaki, H.
Identification and functional analysis of bifunctional ent-kaurene synthase from the moss Physcomitrella patens
FEBS Lett.
580
6175-6181
2006
Physcomitrium patens (A5A8G0), Physcomitrium patens
Manually annotated by BRENDA team
Roy, A.; Roberts, F.G.; Wilderman, P.R.; Zhou, K.; Peters, R.J.; Coates, R.M.
16-Aza-ent-beyerane and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana
J. Am. Chem. Soc.
129
12453-12460
2007
Arabidopsis thaliana (Q9SAK2), Arabidopsis thaliana
Manually annotated by BRENDA team
Boemke, C.; Rojas, M.C.; Gong, F.; Hedden, P.; Tudzynski, B.
Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola
Appl. Environ. Microbiol.
74
5325-5339
2008
Sphaceloma manihoticola (B5DBY7), Sphaceloma manihoticola, Sphaceloma manihoticola Lu949 (B5DBY7)
Manually annotated by BRENDA team
Hayashi, Y.; Toyomasu, T.; Hirose, Y.; Onodera, Y.; Mitsuhashi, W.; Yamane, H.; Sassa, T.; Dairi, T.
Comparison of the enzymatic properties of ent-copalyl diphosphate-synthases in the biosynthesis of phytoalexins and gibberellins in rice
Biosci. Biotechnol. Biochem.
72
523-530
2008
Oryza sativa
Manually annotated by BRENDA team
Morrone, D.; Chambers, J.; Lowry, L.; Kim, G.; Anterola, A.; Bender, K.; Peters, R.J.
Gibberellin biosynthesis in bacteria: separate ent-copalyl diphosphate and ent-kaurene synthases in Bradyrhizobium japonicum
FEBS Lett.
583
475-480
2009
Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110
Manually annotated by BRENDA team
Hayashi, K.I.; Horie, K.; Hiwatashi, Y.; Kawaide, H.; Yamaguchi, S.; Hanada, A.; Nakashima, T.; Nakajima, M.; Mander, L.N.; Yamane, H.; Hasebe, M.; Nozaki, H.
Endogenous diterpenes derived from ent-kaurene, a common gibberellin precursor, regulate protonema differentiation of the moss Physcomitrella patens
Plant Physiol.
153
1085-1097
2010
Physcomitrium patens, Picea glauca (D2X8G1), Picea sitchensis (D2X8G3)
Manually annotated by BRENDA team
Anterola, A.; Shanle, E.; Mansouri, K.; Schuette, S.; Renzaglia, K.
Gibberellin precursor is involved in spore germination in the moss Physcomitrella patens
Planta
229
1003-1007
2009
Physcomitrium patens
Manually annotated by BRENDA team
Pugliesi, C.; Fambrini, M.; Salvini, M.
Molecular cloning and expression profile analysis of three sunflower (Helianthus annuus) diterpene synthase genes
Biochem. Genet.
49
46-62
2011
Helianthus annuus (D4IIJ0), Helianthus annuus (D4IIJ1)
Manually annotated by BRENDA team
Kawaide, H.; Hayashi, K.; Kawanabe, R.; Sakigi, Y.; Matsuo, A.; Natsume, M.; Nozaki, H.
Identification of the single amino acid involved in quenching the ent-kauranyl cation by a water molecule in ent-kaurene synthase of Physcomitrella patens
FEBS J.
278
123-133
2011
Liochlaena subulata, Physcomitrium patens (A5A8G0), Physcomitrium patens
Manually annotated by BRENDA team
Albermann, S.; Linnemannstoens, P.; Tudzynski, B.
Strategies for strain improvement in Fusarium fujikuroi: overexpression and localization of key enzymes of the isoprenoid pathway and their impact on gibberellin biosynthesis
Appl. Microbiol. Biotechnol.
97
2979-2995
2013
Fusarium fujikuroi
Manually annotated by BRENDA team
Shimane, M.; Ueno, Y.; Morisaki, K.; Oogami, S.; Natsume, M.; Hayashi, K.I.; Nozaki, H.; Kawaide, H.
Molecular evolution of the substrate specificity of ent-kaurene synthases to adapt to gibberellin biosynthesis in land plants
Biochem. J.
462
539-546
2014
Selaginella moellendorffii (A0A077JGG8), Selaginella moellendorffii
Manually annotated by BRENDA team
Jackson, A.J.; Hershey, D.M.; Chesnut, T.; Xu, M.; Peters, R.J.
Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization
Phytochemistry
103
13-21
2014
Ricinus communis (B9T625), Ricinus communis
Manually annotated by BRENDA team
Zerbe, P.; Chiang, A.; Bohlmann, J.
Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism
Phytochemistry
74
30-39
2012
Picea glauca
Manually annotated by BRENDA team
Zhou, K.; Xu, M.; Tiernan, M.; Xie, Q.; Toyomasu, T.; Sugawara, C.; Oku, M.; Usui, M.; Mitsuhashi, W.; Chono, M.; Chandler, P.M.; Peters, R.J.
Functional characterization of wheat ent-kaurene(-like) synthases indicates continuing evolution of labdane-related diterpenoid metabolism in the cereals
Phytochemistry
84
47-55
2012
Hordeum vulgare, Triticum aestivum (G9M5S9)
Manually annotated by BRENDA team
Zerbe, P.; Rodriguez, S.M.; Mafu, S.; Chiang, A.; Sandhu, H.K.; ONeil-Johnson, M.; Starks, C.M.; Bohlmann, J.
Exploring diterpene metabolism in non-model species transcriptome-enabled discovery and functional characterization of labda-7,13E-dienyl diphosphate synthase from Grindelia robusta
Plant J.
83
783-793
2015
Grindelia hirsutula (A0A0H4SPM5), Grindelia hirsutula
Manually annotated by BRENDA team
Yamamura, Y.; Taguchi, Y.; Ichitani, K.; Umebara, I.; Ohshita, A.; Kurosaki, F.; Lee, J.B.
Characterization of ent-kaurene synthase and kaurene oxidase involved in gibberellin biosynthesis from Scoparia dulcis
J. Nat. Med.
72
456-463
2018
Scoparia dulcis (F6M9X0), Scoparia dulcis
Manually annotated by BRENDA team
Su, P.; Tong, Y.; Cheng, Q.; Hu, Y.; Zhang, M.; Yang, J.; Teng, Z.; Gao, W.; Huang, L.
Functional characterization of ent-copalyl diphosphate synthase, kaurene synthase and kaurene oxidase in the Salvia miltiorrhiza gibberellin biosynthetic pathway
Sci. Rep.
6
23057
2016
Salvia miltiorrhiza (A0A0U4CDK4), Salvia miltiorrhiza
Manually annotated by BRENDA team
Mukherjee, A.
Computational study of a bifunctional ent-kaurene synthase from Physcomitrella patens (Hedw.) Bruch and Schimp. An insight into the origin of terpenoid biosynthesis in plants
Acta Bot. Gallica
162
139-152
2015
Physcomitrium patens
-
Manually annotated by BRENDA team
Tezuka, D.; Ito, A.; Mitsuhashi, W.; Toyomasu, T.; Imai, R.
The rice ent-kaurene synthase like 2 encodes a functional ent-beyerene synthase
Biochem. Biophys. Res. Commun.
460
766-771
2015
Oryza sativa
Manually annotated by BRENDA team
Mafu, S.; Potter, K.C.; Hillwig, M.L.; Schulte, S.; Criswell, J.; Peters, R.J.
Efficient heterocyclisation by (di)terpene synthases
Chem. Commun. (Camb.)
51
13485-13487
2015
Arabidopsis thaliana, Oryza sativa, Physcomitrium patens, Physcomitrium patens (A5A8G0), Sinorhizobium fredii, Fusarium fujikuroi (S0EA85), Fusarium fujikuroi CBS 195.34 / IMI 58289 / NRRL A-6831 (S0EA85)
Manually annotated by BRENDA team
Jia, M.; Peters, R.J.
Extending a single residue switch for abbreviating catalysis in plant ent-kaurene synthases
Front. Plant Sci.
7
1765
2016
Selaginella moellendorffii (A0A077JGG8), Marchantia polymorpha subsp. ruderalis (A0A176VPW0), Physcomitrium patens (A5A8G0), Picea glauca (D2XEB3), Oryza sativa Japonica Group (Q0JA82), Arabidopsis thaliana (Q9SAK2)
Manually annotated by BRENDA team
Kong, M.K.; Kang, H.J.; Kim, J.H.; Oh, S.H.; Lee, P.C.
Metabolic engineering of the Stevia rebaudiana ent-kaurene biosynthetic pathway in recombinant Escherichia coli
J. Biotechnol.
214
95-102
2015
Stevia rebaudiana, Stevia rebaudiana (Q9XEH9)
Manually annotated by BRENDA team
Jackson, A.; Hershey, D.; Chesnut, T.; Xu, M.; Peters, R.
Biochemical characterization of the castor bean ent-kaurene synthase(-like) family supports quantum chemical view of diterpene cyclization
Phytochemistry
103
13
2014
Ricinus communis (B9SIL7), Ricinus communis
Manually annotated by BRENDA team
Zhan, X.; Bach, S.S.; Hansen, N.L.; Lunde, C.; Simonsen, H.T.
Additional diterpenes from Physcomitrella patens synthesized by copalyl diphosphate/kaurene synthase (PpCPS/KS)
Plant Physiol. Biochem.
96
110-114
2015
Physcomitrium patens (A5A8G0), Physcomitrium patens
Manually annotated by BRENDA team
Miyazaki, S.; Toyoshima, H.; Natsume, M.; Nakajima, M.; Kawaide, H.
Blue-light irradiation up-regulates the ent-kaurene synthase gene and affects the avoidance response of protonemal growth in Physcomitrella patens
Planta
240
117-124
2014
Physcomitrium patens (A5A8G0), Physcomitrium patens
Manually annotated by BRENDA team
Liu, W.; Feng, X.; Zheng, Y.; Huang, C.H.; Nakano, C.; Hoshino, T.; Bogue, S.; Ko, T.P.; Chen, C.C.; Cui, Y.; Li, J.; Wang, I.; Hsu, S.T.; Oldfield, E.; Guo, R.T.
Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum
Sci. Rep.
4
6214
2014
Bradyrhizobium diazoefficiens (Q45222), Bradyrhizobium diazoefficiens JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110 (Q45222)
Manually annotated by BRENDA team