Information on EC 4.2.3.137 - (E)-2-epi-beta-caryophyllene synthase

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The expected taxonomic range for this enzyme is: Selaginella moellendorffii

EC NUMBER
COMMENTARY hide
4.2.3.137
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RECOMMENDED NAME
GeneOntology No.
(E)-2-epi-beta-caryophyllene synthase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Sesquiterpenoid and triterpenoid biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (E)-2-epi-beta-caryophyllene-forming)
Isolated from the plant Selaginella moellendorfii. The enzyme also gives two other sesquiterpenoids.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
(E)-2-epi-beta-caryophyllene + diphosphate
show the reaction diagram
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enzyme shows sesquiterpene synthase activity in vitro. SmMTPSL26 produces three sesquiterpene products that are specific to this enzyme (2-epi-(E)-beta-caryophyllene and unidentified sesquiterpene). SmMTPSL26 does not show diterpene synthase activity
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?
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli
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