Information on EC 4.2.3.123 - beta-sesquiphellandrene synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.2.3.123
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RECOMMENDED NAME
GeneOntology No.
beta-sesquiphellandrene synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2E,6E)-farnesyl diphosphate = beta-sesquiphellandrene + diphosphate
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
(2E,6E)-farnesyl diphosphate diphosphate-lyase (cyclizing, beta-sesquiphellandrene-forming)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
generation of transgenic Arabiopsis thaliana by Agrobacterium-mediated overexpression. Transgenic plants have long hypocotyls, green leaves, and long main roots with the formation of lateral roots. In contrast, the nontransformants show short hypocotyls, bleached out leaves, and no lateral root formation. Transgenic plants show delayed growth, smaller basal rosette leaves and shorter and fewer flowering stems and fewer seeds, compared to the wild-type
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
beta-sesquiphellandrene + diphosphate
show the reaction diagram
(E,E)-farnesyl diphosphate
beta-sesquiphellandrene + diphosphate
show the reaction diagram
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products of Sorghum bicolor Tps1 gene product are 1.4% 7-epi-sesquithujene, 0.5% (E)-alpha-bergamotene, 1.0% sesquiabinene A, 2.7% (E)-beta-farnesene, 61.4% zingiberene, 5.2% beta-bisabolene, 27.8% beta-sesquiphellandrene
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?
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(2E,6E)-farnesyl diphosphate
beta-sesquiphellandrene + diphosphate
show the reaction diagram
C5YHH7, C5YHI2
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?
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.3
calculated
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6100
x * 6100, calculated
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 6100, calculated
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
modeling of three-dimensional structure, based on crystal structure of the 5-epi-aristolochene synthase from tobacco
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli; expression in Escherichia coli
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression is induced after caterpillar-damage to the plant
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
L405V
products are 1.9% 7-epi-sesquithujene, 8.1% (E)-alpha-bergamotene, 8.9% sesquiabinene A, 23.9% (E)-beta-farnesene, 0% gamma-curcumene, 9.7% zingiberene, 12.0% beta-bisabolene, 26.6% beta-sesquiphellandrene, 8.9% (E)-gamma-bisabolene
L405V/Y373S
products are 1.2% 7-epi-sesquithujene, 23.6% (E)-alpha-bergamotene, 17.7% sesquiabinene A, 53.0% (E)-beta-farnesene, 0% gamma-curcumene, 0.6% zingiberene, 1.3% beta-bisabolene, 2.6% beta-sesquiphellandrene, 0% (E)-gamma-bisabolene
Y373S
products are 7.6% 7-epi-sesquithujene, 24.8% (E)-alpha-bergamotene, 18.2% sesquiabinene A, 38.5% (E)-beta-farnesene, 0% gamma-curcumene, 4.7% zingiberene, 2.5% beta-bisabolene, 3.7% beta-sesquiphellandrene, 0% (E)-gamma-bisabolene
L401V
products are 0.4% 7-epi-sesquithujene, 0.7% (E)-alpha-bergamotene, 1.5% sesquiabinene A, 6.2% (E)-beta-farnesene, 0% gamma-curcumene, 8.4% zingiberene, 9.5% beta-bisabolene, 73.3% beta-sesquiphellandrene
L401V/V435S
products 1.3% 7-epi-sesquithujene, 0% (E)-alpha-bergamotene, 2.1% sesquiabinene A, 17.6% (E)-beta-farnesene, 0% gamma-curcumene, 5.8% zingiberene, 30.6% beta-bisabolene, 42.6% beta-sesquiphellandrene
L405L
products are 0.9% 7-epi-sesquithujene, 1.1% (E)-alpha-bergamotene, 0.6% sesquiabinene A, 3.3% (E)-beta-farnesene, 0% gamma-curcumene, 37.5% zingiberene, 7.6% beta-bisabolene, 49.0% beta-sesquiphellandrene
V435S
products are 2.2% 7-epi-sesquithujene, 0% (E)-alpha-bergamotene, 1.7% sesquiabinene A, 5% (E)-beta-farnesene, 0% gamma-curcumene, 17.8% zingiberene, 32.3% beta-bisabolene, 41% beta-sesquiphellandrene
Y369S
products are 1.1% 7-epi-sesquithujene, 0.7% (E)-alpha-bergamotene, 1.3% sesquiabinene A, 48.4% (E)-beta-farnesene, 0.4% gamma-curcumene, 44.8% zingiberene, 1.3% beta-bisabolene, 2.0% beta-sesquiphellandrene
Y369S /V435S
products are 2.5% 7-epi-sesquithujene, 2.9% (E)-alpha-bergamotene, 3.8% sesquiabinene A, 29.6% (E)-beta-farnesene, 0% gamma-curcumene, 18.6% zingiberene, 17.9% beta-bisabolene, 24.7% beta-sesquiphellandrene
Y369S/L401V
products are 2.0% 7-epi-sesquithujene, 11.4% (E)-alpha-bergamotene, 17.6% sesquiabinene A, 29.6% (E)-beta-farnesene, 4.9% gamma-curcumene, 8.2% zingiberene, 6.3% beta-bisabolene, 20% beta-sesquiphellandrene
Y369S/L401V/V435S
products are 2.0% 7-epi-sesquithujene, 6.2% (E)-alpha-bergamotene, 10.1% sesquiabinene A, 36.6% (E)-beta-farnesene, 0% gamma-curcumene, 8.2% zingiberene, 12.6% beta-bisabolene, 24.3% beta-sesquiphellandrene
Y373S
products are 3.3% 7-epi-sesquithujene, 15.6% (E)-alpha-bergamotene, 10.6% sesquiabinene A, 38.9% (E)-beta-farnesene, 0.0% gamma-curcumene, 9.8% zingiberene, 5.0% beta-bisabolene, 16.8% beta-sesquiphellandrene