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6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
7,8-dihydroneopterin 3'-triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
23 bp exon 3 skipping in transcription rather than post-transcriptional mechanisms is a major cause of the low PTPS protein expression in human macrophages and related cell types. The exon lacking leads to a premature stop codon encoding for a shorter protein instead of the full-length functional enzyme
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
assay at
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
rate-limiting enzyme in the synthesis of human tetrahydrobiopterin
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the first step in the conversion of 7,8-dihydroneopterin triphosphate to tetrahydrobiopterin
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme is involved in tetrahydrobiopterin biosynthesis
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway
-
?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin
6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate
-
the enzyme is post-translationally phosphorylated in several Ser residues by protein kinases. The enzyme requires the phosphoserine 19 residue for maximal activity under in vivo conditions. Mutant enzymes with alterations in the protein kinase recognition site, phosphoserine 19 residue, are not phosphorylated by protein kinase and have reduced activity
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
-
-
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
7,8-dihydroneopterin triphosphate
6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
-
assay at
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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4a-hydroxytetrahydrobiopterin dehydratase deficiency
International database of tetrahydrobiopterin deficiencies.
4a-hydroxytetrahydrobiopterin dehydratase deficiency
[Screening of tetrahydrobiopterin deficiency among hyperphenylalaninemic patients]
6,7-dihydropteridine reductase deficiency
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
6,7-dihydropteridine reductase deficiency
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
6,7-dihydropteridine reductase deficiency
International database of tetrahydrobiopterin deficiencies.
6,7-dihydropteridine reductase deficiency
Outcome of Patients With Inherited Neurotransmitter Disorders.
6,7-dihydropteridine reductase deficiency
Reduced nitric oxide metabolites in CSF of patients with tetrahydrobiopterin deficiency.
6,7-dihydropteridine reductase deficiency
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
6,7-dihydropteridine reductase deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
6-pyruvoyltetrahydropterin synthase deficiency
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
6-pyruvoyltetrahydropterin synthase deficiency
6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
6-pyruvoyltetrahydropterin synthase deficiency
6-Pyruvoyltetrahydropterin Synthase Deficiency: Review and Report of 28 Arab Subjects.
6-pyruvoyltetrahydropterin synthase deficiency
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency after screening 1,500,000 newborns in Greece.
6-pyruvoyltetrahydropterin synthase deficiency
A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
6-pyruvoyltetrahydropterin synthase deficiency
Application of isoxanthopterin as a new pterin marker in the differential diagnosis of hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders: Data from the iNTD registry.
6-pyruvoyltetrahydropterin synthase deficiency
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Clinical, biochemical and molecular spectrum of mild 6-pyruvoyl-tetrahydropterin synthase deficiency and a case report.
6-pyruvoyltetrahydropterin synthase deficiency
Detection of phenylketonuria by the newborn screening program in Thailand.
6-pyruvoyltetrahydropterin synthase deficiency
Diagnosis and treatment of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
6-pyruvoyltetrahydropterin synthase deficiency
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
6-pyruvoyltetrahydropterin synthase deficiency
Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan.
6-pyruvoyltetrahydropterin synthase deficiency
Dominant negative allele (N47D) in a compound heterozygote for a variant of 6-pyruvoyltetrahydropterin synthase deficiency causing transient hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders.
6-pyruvoyltetrahydropterin synthase deficiency
Identification of Mutations Causing 6-Pyruvoyl- Tetrahydrobiopterin Synthase Deficiency in Polish Patients With Variant Hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Identification of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency in four Italian families.
6-pyruvoyltetrahydropterin synthase deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
6-pyruvoyltetrahydropterin synthase deficiency
International database of tetrahydrobiopterin deficiencies.
6-pyruvoyltetrahydropterin synthase deficiency
Isolated central form of tetrahydrobiopterin deficiency associated with hemizygosity on chromosome 11q and a mutant allele of PTPS.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term clinical outcome of 6-pyruvoyl-tetrahydropterin synthase-deficient patients.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term follow-up of Taiwanese Chinese patients treated early for 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Long-term outcome and neuroradiological findings of 31 patients with 6-pyruvoyltetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Maternal tetrahydrobiopterin deficiency: The course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Molecular analysis and long-term follow-up of patients with different forms of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Molecular characterization of 6-pyruvoyl-tetrahydropterin synthase deficiency in Japanese patients.
6-pyruvoyltetrahydropterin synthase deficiency
Mutation analysis of the 6-pyruvoyl-tetrahydropterin synthase gene in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Mutations in the pterin-4alpha-carbinolamine dehydratase (PCBD) gene cause a benign form of hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Neopterin and biopterin concentrations in cerebrospinal fluid in controls less than 1 year old.
6-pyruvoyltetrahydropterin synthase deficiency
Neurometabolic diseases at a national referral center: five years experience at the King Faisal Specialist Hospital and Research Centre.
6-pyruvoyltetrahydropterin synthase deficiency
Novel mutation affecting the pterin-binding site of PTS gene and review of PTS mutations in Thai patients with 6-pyruvoyltetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Phenotypic variability, neurological outcome and genetics background of 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
6-pyruvoyltetrahydropterin synthase deficiency
Progression of 6-pyruvoyl-tetrahydropterin synthase deficiency from a peripheral into a central phenotype.
6-pyruvoyltetrahydropterin synthase deficiency
Pseudoexon exclusion by antisense therapy in 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Response of 6-pyruvoyl-tetrahydropterin synthase deficiency to tetrahydrobiopterin.
6-pyruvoyltetrahydropterin synthase deficiency
Retrospective analysis of 19 patients with 6-Pyruvoyl Tetrahydropterin Synthase Deficiency: Prolactin levels inversely correlate with growth.
6-pyruvoyltetrahydropterin synthase deficiency
Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
6-pyruvoyltetrahydropterin synthase deficiency
Screening for tetrahydrobiopterin deficiency among hyperphenylalaninemia patients in Southern China.
6-pyruvoyltetrahydropterin synthase deficiency
Single-step mutation scanning of the 6-pyruvoyltetrahydropterin synthase gene in patients with hyperphenylalaninemia.
6-pyruvoyltetrahydropterin synthase deficiency
Structure, genomic localization and recombinant expression of the mouse 6-pyruvoyl-tetrahydropterin synthase gene.
6-pyruvoyltetrahydropterin synthase deficiency
Subtle brain dysfunction in treated 6-pyruvoyl-tetrahydropterin synthase deficiency: relationship to motor tasks and neurophysiological tests.
6-pyruvoyltetrahydropterin synthase deficiency
Tetrahydrobiopterin biosynthesis defects examined in cytokine-stimulated fibroblasts.
6-pyruvoyltetrahydropterin synthase deficiency
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
6-pyruvoyltetrahydropterin synthase deficiency
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
6-pyruvoyltetrahydropterin synthase deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
6-pyruvoyltetrahydropterin synthase deficiency
WITHDRAWN: Disorders of BH4 metabolism and the treatment of patients with 6-pyruvoyl-tetrahydropterin synthase deficiency in Taiwan.
6-pyruvoyltetrahydropterin synthase deficiency
[Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]
6-pyruvoyltetrahydropterin synthase deficiency
[Mutation analysis and one novel mutation detection of 6-pyruvoyl tetrahydropterin synthase gene in children with tetrahydrobiopterin deficiency]
6-pyruvoyltetrahydropterin synthase deficiency
[Screening for 6-pyruvoyl-tetrahydrobiopterin synthase (PTPS) deficiency: clinical analysis of 9 patients with PTPS deficiency]
6-pyruvoyltetrahydropterin synthase deficiency
[Study on tetrahydrobiopterin deficiency in Northern Chinese population]
6-pyruvoyltetrahydropterin synthase deficiency
[The investigation of differential diagnostic development and incidence of tetrahydrobiopterin deficiency]
Acquired Immunodeficiency Syndrome
Protein tyrosyl phosphatases in T cell activation: implication for human immunodeficiency virus transcriptional activity.
Acute Lung Injury
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Anthrax
Finding the Smoking Gun: Protein Tyrosine Phosphatases as Tools and Targets of Unicellular Microorganisms and Viruses.
aromatic-l-amino-acid decarboxylase deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Arthritis
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Arthritis, Rheumatoid
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Asthma
Protein tyrosine phosphatases regulate asthma development in a murine asthma model.
Asthma
The role of protein tyrosine phosphatases in the regulation of allergic asthma: implication of TC-PTP and PTP-1B in the modulation of disease development.
Atherosclerosis
Low M(r) protein tyrosine phosphatase inhibits growth and migration of vascular smooth muscle cells induced by platelet-derived growth factor.
Autoimmune Diseases
Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete.
Autoimmune Diseases
Bidentate inhibitors of protein tyrosine phosphatases.
Autoimmune Diseases
Covalent inhibition of protein tyrosine phosphatases.
Autoimmune Diseases
Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function.
Autoimmune Diseases
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
Autoimmune Diseases
mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis.
Autoimmune Diseases
Non-receptor tyrosine kinase signaling in autoimmunity and therapeutic implications.
Autoimmune Diseases
Protein tyrosine phosphatase inhibition by metals and metal complexes.
Autoimmune Diseases
Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity.
Autoimmune Diseases
Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity.
Bone Diseases
The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts.
Bone Resorption
The roles of protein tyrosine phosphatases in bone-resorbing osteoclasts.
Bone Resorption
TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function.
Breast Neoplasms
Expression profile of tyrosine phosphatases in HER2 breast cancer cells and tumors.
Breast Neoplasms
Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue.
Breast Neoplasms
Novel PROTACs for degradation of SHP2 protein.
Breast Neoplasms
Protein tyrosine phosphatase PTPN9 negatively regulates ErbB2 and EGFR signaling in breast cancer cells.
Breast Neoplasms
Protein tyrosine phosphatases and breast cancer.
Breast Neoplasms
Protein tyrosine phosphatases as novel targets in breast cancer therapy.
Breast Neoplasms
PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization.
Breast Neoplasms
Targeting protein-tyrosine phosphatases in breast cancer.
Breast Neoplasms
The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells.
Carcinogenesis
A Crosstalk Between Dual-Specific Phosphatases and Dual-Specific Protein Kinases Can Be A Potential Therapeutic Target for Anti-cancer Therapy.
Carcinogenesis
Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo.
Carcinogenesis
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Carcinogenesis
Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.
Carcinogenesis
Targeting PTPs with small molecule inhibitors in cancer treatment.
Carcinogenesis
The role of Shp2 (PTPN11) in cancer.
Carcinogenesis
Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications.
Carcinoma
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Carcinoma, Hepatocellular
Gene expressions of protein tyrosine phosphatases in regenerating rat liver and rat ascites hepatoma cells.
Carcinoma, Hepatocellular
Identification of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency in four Italian families.
Carcinoma, Non-Small-Cell Lung
Novel PROTACs for degradation of SHP2 protein.
Carcinoma, Squamous Cell
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Carcinoma, Squamous Cell
Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion.
Cardiovascular Diseases
Tyrosine phosphatases in vessel wall signaling.
Choriocarcinoma
Optimized logic rules reveal interferon-?-induced modes regulated by histone deacetylases and protein tyrosine phosphatases.
Colonic Neoplasms
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Colorectal Neoplasms
Customized Array Comparative Genomic Hybridization Analysis of 25 Phosphatase-encoding Genes in Colorectal Cancer Tissues.
Colorectal Neoplasms
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Colorectal Neoplasms
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
Colorectal Neoplasms
PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia.
Colorectal Neoplasms
The role of protein tyrosine phosphatases in colorectal cancer.
Complex Regional Pain Syndromes
Reprogramming of in situ spinal cord stimulator for covering newly developed postthoracotomy pain.
Dehydration
Biological mechanisms underlying voice changes due to dehydration.
Diabetes Mellitus, Type 1
Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.
Diabetes Mellitus, Type 1
Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity.
Diabetes Mellitus, Type 1
Protein tyrosine phosphatases and type 1 diabetes: genetic and functional implications of PTPN2 and PTPN22.
Diabetes Mellitus, Type 1
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes.
Diabetes Mellitus, Type 2
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Diabetes Mellitus, Type 2
Inhibitors for proteins endowed with catalytic and non-catalytic activity which recognize pTyr.
Diabetes Mellitus, Type 2
Natural products with protein tyrosine phosphatase inhibitory activity.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities.
Diabetes Mellitus, Type 2
Protein tyrosine phosphatases: molecular switches in metabolism and diabetes.
Diabetes Mellitus, Type 2
Pu-erh tea polysaccharides decrease blood sugar by inhibition of ?-glucosidase activity in vitro and in mice.
Diabetes Mellitus, Type 2
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Diabetic Neuropathies
Identification of differentially expressed genes in dorsal root ganglion in early diabetic rats.
Drug-Related Side Effects and Adverse Reactions
Postmarketing safety and effectiveness of recombinant factor IX (nonacog alfa) in Japanese patients with haemophilia B.
Dyskinesias
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
Dyskinesias
Paroxysmal tremor and orofacial dyskinesia secondary to a biopterin synthesis defect.
Dystonia
6-Pyruvoyl-tetrahydropterin synthase deficiency with generalized dystonia and diurnal fluctuation of symptoms: a clinical and molecular study.
Dystonia
Combined Dystonia With Self-Mutilation in 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: A Case Report.
Dystonia
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Ehlers-Danlos Syndrome
Jerks of the latissimus dorsi muscle and intercostal neuralgia after posterolateral thoracotomy.
Eosinophilia
Protein tyrosine phosphatases regulate asthma development in a murine asthma model.
Esophageal and Gastric Varices
Percutaneous transhepatic portacaval shunt for high-risk esophageal varices.
Esophageal Neoplasms
Expression of protein tyrosine phosphatases and its significance in esophageal cancer.
Genetic Diseases, Inborn
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Genetic Diseases, Inborn
Protein tyrosine phosphatases in health and disease.
Genetic Diseases, Inborn
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Glioma
Protein tyrosine phosphatases in glioma biology.
Glucagonoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[Changes of protein tyrosine phosphorylation in erythrocyte band 3 glucose-6-phosphate dehydrogenase deficiency]
Glucosephosphate Dehydrogenase Deficiency
[Changes of protein tyrosine phosphorylation in erythrocyte band 3 glucose-6-phosphate dehydrogenase deficiency]
Glycogen Storage Disease
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
gtp cyclohydrolase i deficiency
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
gtp cyclohydrolase i deficiency
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
gtp cyclohydrolase i deficiency
International database of tetrahydrobiopterin deficiencies.
gtp cyclohydrolase i deficiency
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
gtp cyclohydrolase i deficiency
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
Heart Failure
Protein tyrosine phosphatases in cardiac physiology and pathophysiology.
Hemophilia A
Clinical Evaluation of Recombinant Factor VIII Preparation (Kogenate) in Previously Treated Patients with Hemophilia A: Descriptive Meta-Analysis of Post-Marketing Study Data.
Hemophilia A
Continued benefit demonstrated with BAY 81-8973 prophylaxis in previously treated children with severe haemophilia A: Interim analysis from the LEOPOLD Kids extension study.
Hemophilia A
Design of the HEM-POWR study: a prospective, observational study of real-world treatment with damoctocog alfa pegol in patients with haemophilia A.
Hemophilia A
Efficacy and safety of pegylated full-length recombinant factor VIII with extended half-life for perioperative haemostasis in haemophilia A patients.
Hemophilia A
Efficacy of a sucrose-formulated recombinant factor VIII used for 22 surgical procedures in patients with severe haemophilia A.
Hemophilia A
Extended half-life pegylated, full-length recombinant factor VIII for prophylaxis in children with severe haemophilia A.
Hemophilia A
Incidence of inhibitors in a cohort of 838 males with hemophilia A previously treated with factor VIII concentrates.
Hemophilia A
Inhibitor development in patients receiving recombinant factor VIII (Recombinate rAHF/Bioclate): a prospective pharmacovigilance study.
Hemophilia A
Interim data on long-term efficacy, safety and tolerability of a plasma-derived factor VIII concentrate in 109 patients with severe haemophilia A.
Hemophilia A
Natural history and clinical characteristics of inhibitors in previously treated haemophilia A patients: a case series.
Hemophilia A
Novel, human cell line-derived recombinant factor VIII (human-cl rhFVIII; Nuwiq(®) ) in adults with severe haemophilia A: efficacy and safety.
Hemophilia A
Pharmacokinetics, immunogenicity, safety, and preliminary efficacy of subcutaneous turoctocog alfa pegol in previously treated patients with severe hemophilia A (alleviate 1).
Hemophilia A
Phase 3 Clinical Trial: Perioperative Use of Nonacog Gamma, a Recombinant Factor IX, in Previously Treated Patients With Moderate/Severe Hemophilia B.
Hemophilia A
Prophylaxis vs. on-demand treatment with Nuwiq(®) (Human-cl rhFVIII) in adults with severe haemophilia A.
Hemophilia A
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Hemophilia B
Pharmacokinetics, safety and efficacy of a recombinant factor IX product, trenonacog alfa in previously treated haemophilia B patients.
Hyperalgesia
Inhibition of protein tyrosine phosphatases in spinal dorsal horn attenuated inflammatory pain by repressing Src signaling.
Hyperesthesia
Neurophysiological Characterization of Persistent Postthoracotomy Pain.
Hyperglycemia
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Hyperhidrosis
A new mode of percutaneous upper thoracic phenol sympathicolysis: report of 50 cases.
Hypersensitivity
From acute to chronic pain after thoracic surgery: the significance of different components of the acute pain response.
Hypersensitivity
Where to prick the apple for skin testing?
Hypotension
Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study.
Immune System Diseases
Natural products with protein tyrosine phosphatase inhibitory activity.
Infections
Blocking of interferon-induced Jak-Stat signaling by Japanese encephalitis virus NS5 through a protein tyrosine phosphatase-mediated mechanism.
Infections
Nitropropenyl benzodioxole, an anti-infective agent with action as a protein tyrosine phosphatase inhibitor.
Infections
Protein tyrosine phosphatases in pathological process.
Infections
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Inflammatory Bowel Diseases
Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
Role of protein tyrosine phosphatases in regulating the immune system: implications for chronic intestinal inflammation.
Insulin Resistance
Effects of a supranutritional dose of selenate compared with selenite on insulin sensitivity in type II diabetic dbdb mice.
Insulin Resistance
Involvement of protein tyrosine phosphatases and inflammation in hypothalamic insulin resistance associated with ageing: Effect of caloric restriction.
Insulin Resistance
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Insulin Resistance
Role of protein tyrosine phosphatases in the modulation of insulin signaling and their implication in the pathogenesis of obesity-linked insulin resistance.
Insulin Resistance
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
Insulin Resistance
Vascular PTPs: current developments and challenges for exploitation in Type 2 diabetes-associated vascular dysfunction.
Insulinoma
Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells.
Insulinoma
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Intellectual Disability
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
Intellectual Disability
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Intellectual Disability
Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.
Leishmaniasis
Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases.
Leishmaniasis
Proteases and phosphatases during Leishmania-macrophage interaction: paving the road for pathogenesis.
Leukemia
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling.
Leukemia
Genetic alterations of protein tyrosine phosphatases in human cancers.
Leukemia
Novel PROTACs for degradation of SHP2 protein.
Leukemia, Myeloid, Acute
Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.
Lung Diseases
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Lung Neoplasms
Erector spinae plane (ESP) block in the management of post thoracotomy pain syndrome: A case series.
Lung Neoplasms
Novel PROTACs for degradation of SHP2 protein.
Lung Neoplasms
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
Lung Neoplasms
Uniportal video-assisted thoracic surgery reduced the occurrence of post-thoracotomy pain syndrome after lobectomy for lung cancer.
Lymphoma, B-Cell
PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.
Malaria
6-Pyruvoyltetrahydropterin Synthase Paralogs Replace the Folate Synthesis Enzyme Dihydroneopterin Aldolase in Diverse Bacteria.
Malaria
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.
Melanoma
Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment.
Melanoma
Protein tyrosine phosphatases, new targets for cancer therapy.
Meningoencephalitis
Distinct and redundant roles of protein tyrosine phosphatases, Ptp1 and Ptp2, in governing the differentiation and pathogenicity of Cryptococcus neoformans.
Metabolic Diseases
The Extended Family of Protein Tyrosine Phosphatases.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Multiple Carboxylase Deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Muscle Hypotonia
Long-term follow-up and adult outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency.
Muscular Diseases
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Myocardial Ischemia
[Effects of electroacupuncture at "Neiguan" (PC 6) on sodium channel-related proteins in rats with ischemic myocardial injury].
Neoplasms
A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.
Neoplasms
A retrospective study of open thoracotomies versus thoracoscopic surgeries for persistent postthoracotomy pain.
Neoplasms
Anchorage-dependent cell growth: tyrosine kinases and phosphatases meet redox regulation.
Neoplasms
Bidentate inhibitors of protein tyrosine phosphatases.
Neoplasms
Checks and balances: Interplay of RTKs and PTPs in cancer progression.
Neoplasms
Covalent inhibition of protein tyrosine phosphatases.
Neoplasms
Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.
Neoplasms
Design, Synthesis, and In Vitro Activity of Pyrazine Compounds.
Neoplasms
Evaluating effects of tyrosine phosphatase inhibitors on T cell receptor signaling.
Neoplasms
Expression of protein tyrosine phosphatases and its significance in esophageal cancer.
Neoplasms
Free-energy profiles for catalysis by dual-specificity phosphatases.
Neoplasms
Genetic alterations of protein tyrosine phosphatases in human cancers.
Neoplasms
High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators.
Neoplasms
Histochemically demonstrable protein tyrosine phosphatase in human breast and colorectal cancer: large decrease in its activity in colorectal cancer suggests a tumor suppressor role in colorectal mucosal cells.
Neoplasms
Identification of adolescents and young adults' preferences and priorities for future cancer treatment using a novel decision-making tool.
Neoplasms
Impact of Oncogenic Protein Tyrosine Phosphatases in Cancer.
Neoplasms
Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.
Neoplasms
Inside the human cancer tyrosine phosphatome.
Neoplasms
Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia.
Neoplasms
Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma.
Neoplasms
MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Neoplasms
Methods to monitor classical protein-tyrosine phosphatase oxidation.
Neoplasms
Mitochondrial Permeability Transition as Target of Anticancer Drugs.
Neoplasms
Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes.
Neoplasms
Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer.
Neoplasms
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Neoplasms
MyPref: pilot study of a novel communication and decision-making tool for adolescents and young adults with advanced cancer.
Neoplasms
Natural products with protein tyrosine phosphatase inhibitory activity.
Neoplasms
Novel PROTACs for degradation of SHP2 protein.
Neoplasms
Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer.
Neoplasms
Phosphotyrosine phosphatases in cancer diagnostic and treatment.
Neoplasms
PRL PTPs: mediators and markers of cancer progression.
Neoplasms
Profile and differential expression of protein tyrosine phosphatases in mouse pancreatic islet tumor cell lines.
Neoplasms
Protein tyrosine phosphatase activity as a diagnostic parameter in breast cancer.
Neoplasms
Protein tyrosine phosphatase inhibition by metals and metal complexes.
Neoplasms
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Neoplasms
Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation.
Neoplasms
Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.
Neoplasms
Protein tyrosine phosphatases in cancer: friends and foes!
Neoplasms
Protein tyrosine phosphatases in disease processes.
Neoplasms
Protein tyrosine phosphatases in pathological process.
Neoplasms
Protein tyrosine phosphatases, new targets for cancer therapy.
Neoplasms
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Neoplasms
Protein tyrosine phosphatases: prospects for therapeutics.
Neoplasms
Protein tyrosine phosphatases: structure-function relationships.
Neoplasms
Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.
Neoplasms
Protein Tyrosine signaling and its potential therapeutic implications in carcinogenesis.
Neoplasms
Protein-tyrosine phosphatases and cancer.
Neoplasms
Protein-tyrosine phosphatases: a new frontier in platelet signal transduction.
Neoplasms
PTEN and myotubularin: novel phosphoinositide phosphatases.
Neoplasms
PTPN9 induces cell apoptosis by mitigating the activation of Stat3 and acts as a tumor suppressor in colorectal cancer.
Neoplasms
PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease.
Neoplasms
PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia.
Neoplasms
Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.
Neoplasms
Role of Protein Tyrosine Phosphatase in Regulation of Cell Signaling Cascades Affecting Tumor Cell Growth: A Future Perspective as Anti- Cancer Drug Target.
Neoplasms
Small molecule targeting of PTPs in cancer.
Neoplasms
Stepping out of the shadows: Oncogenic and tumor-promoting protein tyrosine phosphatases.
Neoplasms
Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling.
Neoplasms
Targeting protein-tyrosine phosphatases in breast cancer.
Neoplasms
Targeting PTPs with small molecule inhibitors in cancer treatment.
Neoplasms
Targeting SHP-1, 2 and SHIP Pathways: A Novel Strategy for Cancer Treatment?
Neoplasms
The Extended Family of Protein Tyrosine Phosphatases.
Neoplasms
The impact of ultrasound-guided continuous serratus anterior plane block versus intravenous patient-controlled analgesia on the incidence and severity of post-thoracotomy pain syndrome: A randomized, controlled study.
Neoplasms
The metal face of protein tyrosine phosphatase 1B.
Neoplasms
The Nonreceptor-Type Tyrosine Phosphatase PTPN13 Is a Tumor Suppressor Gene in Non-Small Cell Lung Cancer.
Neoplasms
The prevalence and risk factors of inhibitor development of FVIII in previously treated patients with hemophilia A.
Neoplasms
The role of protein tyrosine phosphatases in colorectal cancer.
Neoplasms
The role of Shp2 (PTPN11) in cancer.
Neoplasms
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Neoplasms
The tyrosine phosphatase Shp2 (PTPN11) in cancer.
Neoplasms
Therapeutic targeting of oncogenic tyrosine phosphatases.
Neoplasms
trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases.
Neoplasms
Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Neoplasms
Tumor-Suppression Mechanisms of Protein Tyrosine Phosphatase O and Clinical Applications.
Neoplasms
Tumour suppressor function of protein tyrosine phosphatase receptor-T.
Neoplasms
Tyrosine phosphate in melanoma progression.
Neoplasms
Wedelolactone, a naturally occurring coumestan, enhances interferon-? signaling through inhibiting STAT1 protein dephosphorylation.
Nervous System Diseases
Natural products with protein tyrosine phosphatase inhibitory activity.
Nervous System Diseases
Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats.
Neuralgia
A retrospective study of open thoracotomies versus thoracoscopic surgeries for persistent postthoracotomy pain.
Neuralgia
Paravertebral Block Versus Preemptive Ketamine Effect on Pain Intensity after Posterolateral Thoracotomies: A Randomized Controlled Trial.
Neuralgia
Post-thoracotomy pain syndrome: seldom severe, often neuropathic, treated unspecific, and insufficient.
Neuralgia
Postthoracotomy pain syndrome.
Neuralgia
Spinal cord stimulation for treatment of pain in a patient with post thoracotomy pain syndrome.
Neuralgia
The Effect of Pre-Emptive Dexmedetomidine on the Incidence of Post-Thoracotomy Pain Syndrome in Patients Undergoing Coronary Artery Bypass Grafting.
Neurodegenerative Diseases
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Neurodegenerative Diseases
Protein tyrosine phosphatases in pathological process.
Neuroinflammatory Diseases
Comparative Analysis of Protein Tyrosine Phosphatases Regulating Microglial Activation.
Neuroinflammatory Diseases
Protein Tyrosine Phosphatase as Potential Therapeutic Target in various Disorders.
Obesity
A microfluidics-based mobility shift assay to discover new tyrosine phosphatase inhibitors.
Obesity
Covalent inhibition of protein tyrosine phosphatases.
Obesity
Free-energy profiles for catalysis by dual-specificity phosphatases.
Obesity
High-throughput methods in identification of protein tyrosine phosphatase inhibitors and activators.
Obesity
MAPK-specific tyrosine phosphatases: new targets for drug discovery?
Obesity
Molecular analysis of Aedes aegypti classical protein tyrosine phosphatases uncovers an ortholog of mammalian PTP-1B implicated in the control of egg production in mosquitoes.
Obesity
Peptidyl aldehydes as reversible covalent inhibitors of protein tyrosine phosphatases.
Obesity
Recent development of small molecular specific inhibitor of protein tyrosine phosphatase 1B.
Obesity, Abdominal
Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.
Osteoporosis
Glucocorticoid-induced osteoporosis in the rat is prevented by the tyrosine phosphatase inhibitor, sodium orthovanadate.
Ovarian Neoplasms
Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Pancreatic Neoplasms
Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFN? signaling.
Pancreatic Neoplasms
Protein tyrosine phosphatases: promising targets in pancreatic ductal adenocarcinoma.
Paralysis
Abdominal wall bulging after thoracic surgery, an underdiagnosed wound complication.
Paraplegia
Differential brain transcriptome of beta4 nAChR subunit-deficient mice: is it the effect of the null mutation or the background strain?
Paresis
Abdominal wall bulging after thoracic surgery, an underdiagnosed wound complication.
peptidyl-glutamate 4-carboxylase deficiency
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
phenylalanine 4-monooxygenase deficiency
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
Phenylketonurias
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
Phenylketonurias
BH4 deficiency identified in a neonatal screening program for hyperphenylalaninemia.
Phenylketonurias
Chromosomal localization, genomic structure and characterization of the human gene and a retropseudogene for 6-pyruvoyltetrahydropterin synthase.
Phenylketonurias
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Phenylketonurias
Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
Phenylketonurias
Four Years of Diagnostic Challenges with Tetrahydrobiopterin Deficiencies in Iranian Patients.
Phenylketonurias
Human 6-pyruvoyltetrahydropterin synthase: cDNA cloning and heterologous expression of the recombinant enzyme.
Phenylketonurias
Hyperphenylalaninemia due to defects in tetrahydrobiopterin metabolism: molecular characterization of mutations in 6-pyruvoyl-tetrahydropterin synthase.
Phenylketonurias
Identification of a common 6-pyruvoyl-tetrahydropterin synthase mutation at codon 87 in Chinese phenylketonuria caused by tetrahydrobiopterin synthesis deficiency.
Phenylketonurias
Inherited metabolic diseases in the Southern Chinese population: spectrum of diseases and estimated incidence from recurrent mutations.
Phenylketonurias
International database of tetrahydrobiopterin deficiencies.
Phenylketonurias
Isolated central form of tetrahydrobiopterin deficiency associated with hemizygosity on chromosome 11q and a mutant allele of PTPS.
Phenylketonurias
Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Phenylketonurias
Long-term follow-up of Chinese patients who received delayed treatment for 6-pyruvoyl-tetrahydropterin synthase deficiency.
Phenylketonurias
Maternal tetrahydrobiopterin deficiency: The course of two pregnancies and follow-up of two children in a mother with 6-pyruvoyl-tetrahydropterin synthase deficiency.
Phenylketonurias
Molecular genetics of phenylketonuria and tetrahydrobiopterin deficiency in Jordan.
Phenylketonurias
Outcome and long-term follow-up of 36 patients with tetrahydrobiopterin deficiency.
Phenylketonurias
Outcome of Patients With Inherited Neurotransmitter Disorders.
Phenylketonurias
Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain.
Phenylketonurias
Phenylketonuria in Hong Kong Chinese: a call for hyperphenylalaninemia newborn screening in the Special Administrative Region, China.
Phenylketonurias
Possible high frequency of tetrahydrobiopterin deficiency in south Brazil.
Phenylketonurias
Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.
Phenylketonurias
Retrovirus-mediated gene transfer of 6-pyruvoyl-tetrahydropterin synthase corrects tetrahydrobiopterin deficiency in fibroblasts from hyperphenylalaninemic patients.
Phenylketonurias
Role of protein structure in variant annotation: structural insight of mutations causing 6-pyruvoyl-tetrahydropterin synthase deficiency.
Phenylketonurias
Screening for tetrahydrobiopterin deficiencies using dried blood spots on filter paper.
Phenylketonurias
Structure, genomic localization and recombinant expression of the mouse 6-pyruvoyl-tetrahydropterin synthase gene.
Phenylketonurias
Tetrahydrobiopterin deficiencies: Lesson from clinical experience.
Phenylketonurias
Tetrahydrobiopterin deficiency: assay for 6-pyruvoyl-tetrahydropterin synthase activity in erythrocytes, and detection of patients and heterozygous carriers.
Phenylketonurias
Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese.
Phenylketonurias
The treatment and clinical follow-up outcome in Iranian patients with tetrahydrobiopterin deficiency.
Phenylketonurias
Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations.
Phenylketonurias
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Phenylketonurias
[Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]
Phenylketonurias
[Diagnosis, treatment and gene mutation analysis of the first case with dihydropteridine reductase deficiency in the mainland of China]
Phenylketonurias
[Study on tetrahydrobiopterin deficiency in Northern Chinese population]
Phenylketonurias
[The investigation of differential diagnostic development and incidence of tetrahydrobiopterin deficiency]
Pneumonia
Targeting protein tyrosine phosphatase to unravel possible inhibitors for Streptococcus pneumoniae using molecular docking, molecular dynamics simulations coupled with free energy calculations.
Proteinuria
Regulation of mouse podocyte process dynamics by protein tyrosine phosphatases rapid communication.
Pruritus
Impact of fentanyl on acute and chronic pain and its side effects when used with epidural analgesia after thoracic surgery in multimodal analgesia: a retrospective cohort study.
Pulmonary Fibrosis
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Seizures
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
sepiapterin reductase (l-erythro-7,8-dihydrobiopterin forming) deficiency
Assessment of intellectual impairment, health-related quality of life, and behavioral phenotype in patients with neurotransmitter related disorders: Data from the iNTD registry.
sepiapterin reductase (l-erythro-7,8-dihydrobiopterin forming) deficiency
Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients.
Sialorrhea
6-pyruvoyltetrahydropterin synthase deficiency two-case report.
Sleep Initiation and Maintenance Disorders
Thoracic epidural analgesia with morphine does not prevent postthoracotomy pain syndrome: a survey of 159 patients.
Squamous Cell Carcinoma of Head and Neck
Protein tyrosine phosphatase receptor R and Z1 expression are independent prognostic indicators in oral squamous cell carcinoma.
Stomach Neoplasms
Mutational analysis of the tyrosine phosphatome in colorectal cancers.
Stomach Neoplasms
Protein tyrosine-phosphatase expression profiling in gastric cancer tissues.
succinate-semialdehyde dehydrogenase [nad(p)+] deficiency
Outcome of Patients With Inherited Neurotransmitter Disorders.
Thoracic Diseases
Uniportal video-assisted thoracic surgery reduced the occurrence of post-thoracotomy pain syndrome after lobectomy for lung cancer.
Thrombosis
Protein-tyrosine phosphatases: a new frontier in platelet signal transduction.
Thrombosis
[Pathological anatomy of the post-thrombophlebitic syndrome]
Tremor
Paroxysmal tremor and orofacial dyskinesia secondary to a biopterin synthesis defect.
Tuberculosis
Bidentate inhibitors of protein tyrosine phosphatases.
Tuberculosis
Finding the Smoking Gun: Protein Tyrosine Phosphatases as Tools and Targets of Unicellular Microorganisms and Viruses.
Tuberculosis, Multidrug-Resistant
Multidrug-Resistant Tuberculosis in Burkina Faso from 2006 to 2017: Results of National Surveys.
Vaccinia
A selective Seoul-Fluor-based bioprobe, SfBP, for vaccinia H1-related phosphatase--a dual-specific protein tyrosine phosphatase.
Vaccinia
Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida.
Vaccinia
Small molecule tools for functional interrogation of protein tyrosine phosphatases.
Varicose Veins
Blood supply routes of recurrent esophageal varices following endoscopic embolization.
Vascular Diseases
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.
Vascular System Injuries
Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors.
Whooping Cough
Receptor-type protein tyrosine phosphatase zeta as a component of the signaling receptor complex for midkine-dependent survival of embryonic neurons.
Whooping Cough
The phosphotyrosine phosphatase eta mediates somatostatin inhibition of glioma proliferation via the dephosphorylation of ERK1/2.
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Thny, B.; Leimbacher, W.; Blau, N.; Heizmann, C.W.; Burgisser, D.
Human liver 6-pyruvoyl-tetrahydropterin synthase: expression of the cDNA, purification and preliminary characterization of the recombinant protein
Adv. Exp. Med. Biol.
338
187-190
1993
Homo sapiens, Rattus norvegicus
brenda
Guzman, J.; Redweik, U.; Schoedon, G.; Hunziker, P.; Wiestler, O.D.; Heizmann, C.W.; Blau, N.
Purification and characterization of 6-pyruvoyl tetrahydropterin synthase from human pituitary gland
Enzyme
46
287-298
1992
Drosophila melanogaster, Homo sapiens, Salmo salar
brenda
Takikawa, S.; Curtius, H.Ch.; Redweik, U.; Ghisla, S.
Purification of 6-pyruvoyl-tetrahydropterin synthase from human liver
Biochem. Biophys. Res. Commun.
134
646-651
1986
Homo sapiens
brenda
Ashida, A.; Hatakeyama, K.; Kagamiyama, H.
cDNA cloning, expression in Escherichia coli and purification of human 6-pyruvoyl-tetrahydropterin synthase
Biochem. Biophys. Res. Commun.
195
1386-1393
1993
Homo sapiens (Q03393), Homo sapiens
brenda
Auerbach, G.; Nar, H.
The pathway from GTP to tetrahydropterin: three-dimensional structures of GTP cyclohydrolase I and 6-pyruvoyl tetrahydropterin synthase
Biol. Chem.
378
185-192
1997
Bombyx mori, Bos taurus, Drosophila melanogaster, Homo sapiens, Rattus norvegicus (P27213)
brenda
Burgisser, D.M.; Thny, B.; Redweik, U.; Hunziker, P.; Heizmann, C.W.; Blau, N.
Expression and characterization of recombinant human and rat liver 6-pyruvoyl tetrahydropterin synthase. Modified cysteine residues inhibit the enzyme activity
Eur. J. Biochem.
219
497-502
1994
Homo sapiens, Rattus norvegicus
brenda
Oppliger, T.; Thny, B.; Nar, H.; Burgisser, D.; Huber, R.; Heizmann, C.W.; Blau, N.
Structural and functional consequences of mutations in 6-pyruvoyltetrahydropterin synthase causing hyperphenylalaninemia in humans
J. Biol. Chem.
270
29498-29506
1995
Homo sapiens
brenda
Takikawa, S.; Curtius, H.C.; Redweik, U.; Leimbacher, W.; Ghisla, S.
Biosynthesis of tetrahydropterin. Purification and characterization of 6-pyruvoyl-tetrahydropterin synthase from human liver
Eur. J. Biochem.
161
295-302
1986
Homo sapiens
brenda
Woo, H.J.; Hwang, Y.K.; Kim, Y.J.; Kang, J.Y.; Choi, Y.K.; Kim, C.G.; Park, Y.S.
Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin
FEBS Lett.
523
234-238
2002
Synechocystis sp., Drosophila melanogaster, Escherichia coli, Homo sapiens
brenda
Scherer-Oppliger, T.; Leimbacher, W.; Blau, N.; Thony, B.
Serine 19 of human 6-pyruvoyltetrahydropterin synthase is phosphorylated by cGMP protein kinase II
J. Biol. Chem.
274
31341-31348
1999
Homo sapiens
brenda
Leitner, K.L.; Meyer, M.; Leimbacher, W.; Peterbauer, A.; Hofer, S.; Heufler, C.; Mueller, A.; Heller, R.; Werner, E.R.; Thoeny, B.; Werner-Felmayer, G.
Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase
Biochem. J.
373
681-688
2003
Homo sapiens (Q03393), Homo sapiens
brenda
Bracher, A.; Eisenreich, W.; Schramek, N.; Ritz, H.; Gotze, E.; Herrmann, A.; Gutlich, M.; Bacher, A.
Biosynthesis of pteridines. NMR studies on the reaction mechanisms of GTP cyclohydrolase I, pyruvoyltetrahydropterin synthase, and sepiapterin reductase
J. Biol. Chem.
273
28132-28141
1998
Homo sapiens
brenda
Linscheid, P.; Schaffner, A.; Blau, N.; Schoedon, G.
Regulation of 6-pyruvoyltetrahydropterin synthase activity and messenger RNA abundance in human vascular endothelial cells
Circulation
98
1703-1706
1998
Homo sapiens (Q03393), Homo sapiens
brenda
Liu, T.T.; Hsiao, K.J.; Lu, S.F.; Wu, S.J.; Wu, K.F.; Chiang, S.H.; Liu, X.Q.; Chen, R.G.; Yu, W.M.
Mutation analysis of the 6-pyruvoyl-tetrahydropterin synthase gene in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthesis deficiency
Hum. Mutat.
11
76-83
1998
Homo sapiens
brenda
Tachibana, D.; Fukumasu, H.; Shintaku, H.; Fukumasu, Y.; Yamamasu, S.; Ishiko, O.; Yamano, T.; Ogita, S.
Decreased plasma tetrahydrobiopterin in pregnant women is caused by impaired 6-pyruvoyl tetrahydropterin synthase activity
Int. J. Mol. Med.
9
49-52
2002
Homo sapiens
brenda
Elzaouk, L.; Laufs, S.; Heerklotz, D.; Leimbacher, W.; Blau, N.; Resibois, A.; Thoeny, B.
Nuclear localization of tetrahydrobiopterin biosynthetic enzymes
Biochim. Biophys. Acta
1670
56-68
2004
Chlorocebus aethiops, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Franscini, N.; Bachli, E.B.; Blau, N.; Fischler, M.; Walter, R.B.; Schaffner, A.; Schoedon, G.
Functional tetrahydrobiopterin synthesis in human platelets
Circulation
110
186-192
2004
Homo sapiens
brenda
Iwanaga, N.; Yamamasu, S.I.; Tachibana, D.; Nishio, J.; Nakai, Y.; Shintaku, H.; Ishiko, O.
Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta
Int. J. Mol. Med.
13
117-120
2004
Homo sapiens
brenda
Thoeny, B.; Blau, N.
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Hum. Mutat.
27
870-878
2006
Homo sapiens
brenda
Sato, K.; Sumi-Ichinose, C.; Kaji, R.; Ikemoto, K.; Nomura, T.; Nagatsu, I.; Ichinose, H.; Ito, M.; Sako, W.; Nagahiro, S.; Graybiel, A.M.; Goto, S.
Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia
Proc. Natl. Acad. Sci. USA
105
12551-12556
2008
Homo sapiens
brenda
Park, E.H.; Lee, W.H.; Jang, M.H.; Kim, M.D.
Optimization of expression conditions enhances production of sepiapterin, a precursor for tetrahydrobiopterin biosynthesis, in recombinant Escherichia coli
J. Microbiol. Biotechnol.
25
1709-1713
2015
Homo sapiens (Q03393), Homo sapiens
brenda
4.2.3.12 6-pyruvoyltetrahydropterin synthase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
