Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 4.2.2.7 - heparin lyase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Pathogenicity of anaerobic bacteria.
Acute Kidney Injury
Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application.
Adenocarcinoma
Heparan sulfate, heparin, and heparinase activity detection on polyacrylamide gel electrophoresis using the fluorochrome tris(2,2'-bipyridine) ruthenium (II).
Alzheimer Disease
Characterization of proteoglycans in Alzheimer's disease fibroblasts.
Carcinoma, Hepatocellular
Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells.
[Study of expression of CD138 and heparinase in hepatocellular carcinoma by tissue microarray]
Colonic Neoplasms
Cancer invasion regulates vascular complexity in a three-dimensional biomimetic model.
Coronary Artery Disease
Modified high-throughput quantification of plasma microRNAs in heparinized patients with coronary artery disease using heparinase.
COVID-19
Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient: A case report.
Dengue
Identification of a putative coreceptor on Vero cells that participates in dengue 4 virus infection.
Diabetes Mellitus, Type 2
Amyloid formation in human islets is enhanced by heparin and inhibited by heparinase.
Endocarditis
Experimental Bacteroides fragilis endocarditis in rabbits.
Fibrosarcoma
Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90? and Hsp90? to the cell plasma membrane.
Cell surface heparan sulfate proteoglycans are involved in the extracellular Hsp90-stimulated migration and invasion of cancer cells.
The digestion of cell surface-associated glycosaminoglycans by crude and purified flavobacter heparinum enzymes: disparate effects on cell adhesion.
Glioblastoma
Cell surface heparan sulfate proteoglycans are involved in the binding of Hsp90? and Hsp90? to the cell plasma membrane.
Cell surface heparan sulfate proteoglycans are involved in the extracellular Hsp90-stimulated migration and invasion of cancer cells.
Heart Diseases
Regional heparinization via simultaneous separation and reaction in a novel Taylor-Couette flow device.
Hypersensitivity
Use of heparinase I in a patient with protamine allergy undergoing redo myocardial revascularization.
Infections
A Genome-Wide CRISPR-Cas9 Screen Reveals the Requirement of Host Cell Sulfation for Schmallenberg Virus Infection.
A human cytomegalovirus glycoprotein complex designated gC-II is a major heparin-binding component of the envelope.
Analysis of the infectious entry pathway of human papillomavirus type 33 pseudovirions.
Cell membrane bound N-acetylneuraminic acid is involved in the infection of fibroblasts and phorbol-ester differentiated monocyte-like cells with human cytomegalovirus (HCMV).
Coagulation factors IX and X enhance binding and infection of adenovirus types 5 and 31 in human epithelial cells.
DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans.
Dengue virus binding to human leukocyte cell lines: receptor usage differs between cell types and virus strains.
Echoviruses bind heparan sulfate at the cell surface.
Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate.
Endogenous heparin-like activity detected by anti-Xa assay in infected cirrhotic and non-cirrhotic patients.
Enterovirus 71 uses cell surface heparan sulfate glycosaminoglycan as an attachment receptor.
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium.
Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer.
Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells.
Heparan Sulfate Proteoglycans are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection.
Heparan sulfate proteoglycans mediate the invasion of cardiomyocytes by Trypanosoma cruzi.
Heparin-like effect in liver disease and liver transplantation.
Heparinase Is Essential for Pseudomonas aeruginosa Virulence during Thermal Injury and Infection.
Heparinase production by anaerobic bacteria.
Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans.
Human papillomavirus type 31b infection of human keratinocytes does not require heparan sulfate.
Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans.
Inhibition of transfer to secondary receptors by heparan sulfate-binding drug or antibody induces noninfectious uptake of human papillomavirus.
Involvement of the matrix protein in attachment of porcine reproductive and respiratory syndrome virus to a heparinlike receptor on porcine alveolar macrophages.
MHC proteins and heparan sulphate proteoglycans regulate murine cytomegalovirus infection.
Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor.
Passage of classical swine fever virus in cultured swine kidney cells selects virus variants that bind to heparan sulfate due to a single amino acid change in envelope protein E(rns).
Porcine epidemic diarrhea virus uses cell-surface heparan sulfate as an attachment factor.
Role of glycosaminoglycans for binding and infection of hepatitis B virus.
Role of heparan sulfate in human parainfluenza virus type 3 infection.
Role of Syndecan-4 in the cellular invasion of Orientia tsutsugamushi.
The Chlamydia outer membrane protein OmcB is required for adhesion and exhibits biovar-specific differences in glycosaminoglycan binding.
The MisR/MisS two-component regulatory system influences inner core structure and immunotype of lipooligosaccharide in Neisseria meningitidis.
Lewy Body Disease
Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases.
Lung Injury
Discovery of enzymatically depolymerized heparins capable of treating Bleomycin-induced pulmonary injury and fibrosis in mice.
Mastocytoma
Biosynthesis of heparin/heparan sulfate. The D-glucosaminyl 3-O-sulfotransferase reaction: target and inhibitor saccharides.
Cleavage of macromolecular heparin by an enzyme from mouse mastocytoma.
Measles
Analysis of the molecules involved in human T-cell leukaemia virus type 1 entry by a vesicular stomatitis virus pseudotype bearing its envelope glycoproteins.
Melanoma
Enhanced anti-metastatic therapy with down-regulation of heparinase expression by ROS-responsive micellar nanoparticles.
Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
The digestion of cell surface-associated glycosaminoglycans by crude and purified flavobacter heparinum enzymes: disparate effects on cell adhesion.
Melanoma, Experimental
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
Meningococcal Infections
Candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: developmental chemistry and investigation of immunological responses following immunization of mice and rabbits.
Mucopolysaccharidosis II
Differences in the nonreducing ends of heparan sulfates excreted by patients with mucopolysaccharidoses revealed by bacterial heparitinases: a new tool for structural studies and differential diagnosis of Sanfilippo's and Hunter's syndromes.
Neoplasm Metastasis
Cancer invasion regulates vascular complexity in a three-dimensional biomimetic model.
Enhanced anti-metastatic therapy with down-regulation of heparinase expression by ROS-responsive micellar nanoparticles.
Post-TACE Combination Therapy of Heparin and Octreotide Results in Decreased Tumor Metastasis in Extrahepatic Tumorigenesis.
[Study of expression of CD138 and heparinase in hepatocellular carcinoma by tissue microarray]
Neoplasms
An uncommon cause of postoperative bleeding.
Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion.
Cancer invasion regulates vascular complexity in a three-dimensional biomimetic model.
Chemically modified heparin inhibits in vitro L-selectin-mediated human ovarian carcinoma cell adhesion.
Chemically modified heparin inhibits the in vitro adhesion of nonsmall cell lung cancer cells to P-selectin.
Enhanced anti-metastatic therapy with down-regulation of heparinase expression by ROS-responsive micellar nanoparticles.
Heparan sulfate analogues regulate tumor-derived exosome formation that attenuates exosome functions in tumor processes.
Heparan sulfate chains contribute to the anticoagulant milieu in malignant pleural effusion.
Heparin immobilized gold nanoparticles for targeted detection and apoptotic death of metastatic cancer cells.
Heparinase enables reliable quantification of circulating tumor DNA from heparinized plasma samples by droplet digital PCR.
In vitro and ex vivo evaluation of a multi-epitope heparinase vaccine for various malignancies.
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
Post-TACE Combination Therapy of Heparin and Octreotide Results in Decreased Tumor Metastasis in Extrahepatic Tumorigenesis.
[Histochemical studies of bladder tumors]
[Research progress of heparinase in the field of medicine].
[Study of expression of CD138 and heparinase in hepatocellular carcinoma by tissue microarray]
Ovarian Neoplasms
Combined detection of serum matrix metalloproteinase 9, acetyl heparinase and cathepsin L in diagnosis of ovarian cancer.
Paralysis
Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases.
Periodontal Diseases
Heparinase activity in lesion of periodontal diseases.
Pulmonary Embolism
Anticoagulant pharmacodynamics of tinzaparin following 175 iu/kg subcutaneous administration to healthy volunteers.
Renal Insufficiency
Regional heparinization via simultaneous separation and reaction in a novel Taylor-Couette flow device.
Rhabdomyosarcoma
Echoviruses bind heparan sulfate at the cell surface.
Rheumatic Diseases
[Mechanism responsible for the rise of heparinase level in children with rheumatism]
Rift Valley Fever
A Genome-Wide CRISPR-Cas9 Screen Reveals the Requirement of Host Cell Sulfation for Schmallenberg Virus Infection.
ST Elevation Myocardial Infarction
Overcoming Heparin-Associated RT-qPCR Inhibition and Normalization Issues for microRNA Quantification in Patients with Acute Myocardial Infarction.
Stomach Neoplasms
[Immune response of heparanase gene modified dendritic cell-based vaccine on gastric cancer cells]
Supranuclear Palsy, Progressive
Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases.
Thrombocytopenia
The use of heparinase improves the specificity of crossreactivity testing in heparin-induced thrombocytopenia.
Thrombophlebitis
Heparinase production by anaerobic bacteria.
Thrombosis
Anticoagulant pharmacodynamics of tinzaparin following 175 iu/kg subcutaneous administration to healthy volunteers.
Anticoagulation Management during First Five Days of Infant-Pediatric Extracorporeal Life Support.
Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin.
Multicentric evaluation of heparinase on aPTT, thrombin clotting time and a new PT reagent based on recombinant human tissue factor.
Uterine Cervical Neoplasms
Human papillomavirus type 31b infection of human keratinocytes does not require heparan sulfate.
Venous Thrombosis
Anticoagulant pharmacodynamics of tinzaparin following 175 iu/kg subcutaneous administration to healthy volunteers.
Multicentric evaluation of heparinase on aPTT, thrombin clotting time and a new PT reagent based on recombinant human tissue factor.
von Willebrand Diseases
Heparinase and thromboelastography in liver transplantation for a patient with von Willebrand's disease.
Zika Virus Infection
Polysulfonate suramin inhibits Zika virus infection.