Information on EC 4.2.1.B25 - phenyllactyl-CoA dehydratase

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The expected taxonomic range for this enzyme is: Clostridium sporogenes

EC NUMBER
COMMENTARY hide
4.2.1.B25
preliminary BRENDA-supplied EC number
RECOMMENDED NAME
GeneOntology No.
phenyllactyl-CoA dehydratase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(R)-3-phenyllactyl-CoA = (2R)-2-hydroxy-3-phenylpropanoyl-CoA + H2O
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
(R)-3-phenyllactyl-CoA hydro-lyase
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Q93AL9: subunit FldB, Q93AL8: subunit FldB
Q93AL9 and Q93AL8
UniProt
Manually annotated by BRENDA team
Q93AL9: subunit FldB, Q93AL8: subunit FldB
Q93AL9 and Q93AL8
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-3-phenyllactoyl-CoA
(2R)-2-hydroxy-3-phenylpropanoyl-CoA + H2O
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(R)-3-phenyllactoyl-CoA
(2R)-2-hydroxy-3-phenylpropanoyl-CoA + H2O
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
FAD
Q93AL9 and Q93AL8
enzyme contains FAD
[4Fe-4S]-center
Q93AL9 and Q93AL8
contains a [4Fe-4S]2+ cluster
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8
Q93AL9 and Q93AL8
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
20
Q93AL9 and Q93AL8
assay at
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
Q93AL9 and Q93AL8
1 * 46000 (FldA), 1 * 43000 (FldB), 1 * 40000 (FldC), the 46000 Da FldA subunit mediates CoA-transfer to phenyllactate, subunits FldBC mediate dehydration of phenyllactyl-CoA to cinnamoyl-CoA, SDS-PAGE
43000
Q93AL9 and Q93AL8
1 * 46000 (FldA), 1 * 43000 (FldB), 1 * 40000 (FldC), the 46000 Da FldA subunit mediates CoA-transfer to phenyllactate, subunits FldBC mediate dehydration of phenyllactyl-CoA to cinnamoyl-CoA, SDS-PAGE
46000
Q93AL9 and Q93AL8
1 * 46000 (FldA), 1 * 43000 (FldB), 1 * 40000 (FldC), the 46000 Da FldA subunit mediates CoA-transfer to phenyllactate, subunits FldBC mediate dehydration of phenyllactyl-CoA to cinnamoyl-CoA, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
heterotrimer
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
oxygen sensitive with a half-life of approximately 12 h
Q93AL9 and Q93AL8
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
-
Q93AL9 and Q93AL8