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Information on EC 4.2.1.70 - pseudouridylate synthase and Organism(s) Mus musculus and UniProt Accession Q9JI38

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.70 pseudouridylate synthase
IUBMB Comments
The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo .
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This record set is specific for:
Mus musculus
UNIPROT: Q9JI38
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
pseudouridine synthase, p35 protein, pseudouridine synthase i, pseudouridylate synthase, psi55 synthase, pseudouridylate synthetase, pseudouridine-5'-phosphate glycosidase, trna pseudouridine 55 synthase, orp protein, psi55 trna pseudouridine synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
16S pseudouridine 516 synthase
-
-
-
-
16S pseudouridylate 516 synthase
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-
-
-
5-ribosyluracil 5'-phosphate synthetase
-
-
-
-
Depressed growth-RATE protein DEG1
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-
-
-
ORP protein
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-
-
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Osmoprotectant regulator of PLC
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-
-
-
P35 protein
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-
-
-
pseudouridine monophosphate synthetase
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-
-
-
pseudouridine synthase
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-
-
-
pseudouridine synthase I
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-
-
-
Pseudouridylate synthase
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-
-
-
pseudouridylate synthetase
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-
-
-
pseudouridylate synthetase I
-
-
-
-
pseudouridylate synthetase II
-
-
-
-
pseudouridylic acid synthetase
-
-
-
-
PSI55 synthase
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-
-
-
psiMP synthetase
-
-
-
-
psisynthetase
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-
-
-
psiUMP synthetase
-
-
-
-
PSUI
-
-
-
-
synthase, pseudouridylate
-
-
-
-
tRNA pseudouridine 55 synthase
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-
-
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uracil hydrolyase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
addition
-
of H2O
PATHWAY SOURCE
PATHWAYS
-
-
SYSTEMATIC NAME
IUBMB Comments
uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)
The reaction it readily reversible. While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo [5].
CAS REGISTRY NUMBER
COMMENTARY hide
9023-35-2
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
mPus3p
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PUS3_MOUSE
481
0
55546
Swiss-Prot
Mitochondrion (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
46610
-
pus1p, calculation from sequence of cDNA
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
Pus1p, expression in Escherichia coli
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chen, J.; Patton, J.R.
Cloning and characterization of a mammalian pseudouridine synthase
RNA
5
409-419
1999
Escherichia coli, Mus musculus
Manually annotated by BRENDA team
Chen, J.; Patton, J.
Mouse pseudouridine synthase I: gene structure and alternative splicing of pre-mRNA
Biochem. J.
352
465-473
2000
Mus musculus (Q9WU56), Mus musculus
Manually annotated by BRENDA team
Chen, J.; Patton, J.R.
Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA
Biochemistry
39
12723-12730
2000
Mus musculus (Q9JI38)
Manually annotated by BRENDA team