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uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
pseudouridine 5' phosphate + H2O
?
pseudouridine 5'-phosphate + H2O
uracil + D-ribose 5-phosphate
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
additional information
?
-
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
-
-
-
r
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
the enzyme is involved in the metabolism of pseudouridine in uropathogenic Escherichia coli
-
-
r
pseudouridine 5' phosphate + H2O
?
-
a catabolite-repressible enzyme. Enzyme is involved in the utilization in vivo of exogenous pseudouridine
-
-
?
pseudouridine 5' phosphate + H2O
?
-
growth on pseudouridine as sole pyrimidine source
-
-
?
pseudouridine 5'-phosphate + H2O
uracil + D-ribose 5-phosphate
-
-
-
?
pseudouridine 5'-phosphate + H2O
uracil + D-ribose 5-phosphate
-
-
-
?
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
-
-
-
?
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
-
-
-
?
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
-
-
-
?
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
-
-
-
-
?
uracil + D-ribose 5-phosphate
pseudouridine 5'-phosphate + H2O
-
r
-
?
additional information
?
-
measuring the production of ribose 5-phosphate with a ribose-5-phosphate isomerase/ribulose-5-phosphate reductase-coupled assay, no activity with ribonucleotide monophosphates AMP, UMP, GMP, and CMP, overview
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-
?
additional information
?
-
-
measuring the production of ribose 5-phosphate with a ribose-5-phosphate isomerase/ribulose-5-phosphate reductase-coupled assay, no activity with ribonucleotide monophosphates AMP, UMP, GMP, and CMP, overview
-
-
?
additional information
?
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-
mutation of the genlocus hisT causes lack of pseudouridylate synthetase activity. The defect in this enzyme leads to the absence of pseudouridines in the anticodon loop of several tRNA species
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-
?
additional information
?
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-
pseudouridine synthase I activity is missing in extracts of strain EB146 (leuK16)
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-
?
additional information
?
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-
genetic link between tRNA pseudouridine modification and vitamin B6 biosynthesis
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-
?
additional information
?
-
-
the enzyme catalyzes pseudouridylation at position 55 in the T-pseudouridine-C arm of all elongator tRNAs
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-
?
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Breitman, T.R.
Pseudouridylate synthetase of Escherichia coli: correlation of its activity with utilization of pseudouridine for growth
J. Bacteriol.
103
263-264
1970
Escherichia coli
brenda
Salomon, L.R.; Breitman, T.R.
Pseudouridylate synthetase of Escherichia coli: a catabolite-repressible enzyme
J. Bacteriol.
107
535-542
1971
Escherichia coli
brenda
Remsen, J.F.; Matsushita, T.; Chirikjian, J.G.; Davis, F.F.
Enzymatic synthesis of deoxypseudouridylic acid an a study of certain of its properties
Biochim. Biophys. Acta
281
481-487
1972
Agrobacterium tumefaciens, Escherichia coli, Tetrahymena pyriformis, Agrobacterium tumefaciens ATCC 15955
brenda
Bruni, C.B.; Colantuoni, V.; Sbordone, L.; Cortese, R.; Blasi, F.
Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants
J. Bacteriol.
130
4-10
1977
Escherichia coli
brenda
Frendewey, D.A.; Kladianos, D.M.; Moore, V.G.; Kaiser, I.I.
Loss of tRNA 5-methyluridine methyltransferase and pseudouridine synthetase activities in 5-fluorouracil and 1-(tetrahydro-2-furanyl)-5-fluorouracil (ftorafur)-treated Escherichia coli
Biochim. Biophys. Acta
697
31-40
1982
Escherichia coli
brenda
Marvel, C.C.; Arps, P.J.; Rubin, B.C.; Kammen, H.O.; Penhoet, E.E.; Winkler, M.E.
HisT is part of a multigene operon in Escherichia coli K-12
J. Bacteriol.
161
60-71
1985
Escherichia coli
brenda
Searles, L.L.; Jones, J.W.; Fournier, M.J.; Grambow, N.; Tyler, B.; Calvo, J.M.
Escherichia coli B/r leuK mutant lacking pseudouridine synthase I
J. Bacteriol.
166
341-345
1986
Escherichia coli, Escherichia coli EB146 (leuK16)
brenda
Arps, P.J.; Winkler, M.E.
An unusual genetic link between vitamin B6 biosynthesis and tRNA pseudouridine modification in Escherichia coli K-12
J. Bacteriol.
169
1071-1079
1987
Escherichia coli
brenda
Arps, P.J.; Winkler, M.E.
Structural analysis of the Escherichia coli K-12 hisT operon by using a kanamycin resistance cassette
J. Bacteriol.
169
1061-1070
1987
Escherichia coli
brenda
Corollo, D.; Blair-Johnson, M.; Conrad, J.; Friedler, T.; Sun, D.; Wang, L.; Ofengand, J.; Fenna, R.
Crystallisation and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli
Acta Crystallogr. Sect. D
55
302-304
1999
Escherichia coli
-
brenda
Chen, J.; Patton, J.R.
Cloning and characterization of a mammalian pseudouridine synthase
RNA
5
409-419
1999
Escherichia coli, Mus musculus
brenda
Foster, P.G.; Huang, L.; Santi, D.; Stroud, R.
The structural basis of tRNA recognition and pseudouridine formation by pseudouridine synthase I
Nat. Struct. Biol.
7
23-27
2000
Escherichia coli
brenda
Wouters, J.; Tricot, C.; Durbecq, V.; Roovers, M.; Stalon, V.; Droogmans, L.
Preliminary X-ray crystallographic analysis of tRNA pseudouridine 55 synthase from the thermophilic eubacterium Thermotoga maritima
Acta Crystallogr. Sect. D
59
152-154
2003
Escherichia coli, Escherichia coli TruB, Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
brenda
Del Campo, M.; Ofengand, J.; Malhotra, A.
Purification and crystallization of Escherichia coli pseudouridine synthase RluD
Acta Crystallogr. Sect. D
59
1871-1873
2003
Escherichia coli, Escherichia coli RluD
brenda
Ericsson, U.B.; Andersson, M.E.; Engvall, B.; Nordlund, P.; Hallberg, B.M.
Expression, purification, crystallization and preliminary diffraction studies of the tRNA pseudouridine synthase TruD from Escherichia coli
Acta Crystallogr. Sect. D
60
775-776
2004
Escherichia coli
brenda
Hoang, C.; Ferre-D'Amare, A.R.
Cocrystal structure of a tRNA psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme
Cell
107
929-939
2001
Escherichia coli, Escherichia coli TruB
brenda
Kaya, Y.; Del Campo, M.; Ofengand, J.; Malhotra, A.
Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold
J. Biol. Chem.
279
18107-18110
2004
Escherichia coli
brenda
Sivaraman, J.; Iannuzzi, P.; Cygler, M.; Matte, A.
Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli
J. Mol. Biol.
335
87-101
2004
Escherichia coli, Escherichia coli RluD
brenda
Sivaraman, J.; Sauve, V.; Larocque, R.; Stura, E.A.; Schrag, J.D.; Cygler, M.; Matte, A.
Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP
Nat. Struct. Biol.
9
353-358
2002
Escherichia coli, Escherichia coli RsuA
brenda
Pan, H.; Agarwalla, S.; Moustakas, D.T.; Finer-Moore, J.; Stroud, R.M.
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit
Proc. Natl. Acad. Sci. USA
100
12648-12653
2003
Escherichia coli, Thermotoga maritima, Thermotoga maritima TruB, Escherichia coli TruB
brenda
Gu, X.; Liu, Y.; Santi, D.V.
The mechanism of pseudouridine synthase I as deduced from its interaction with 5-fluorouracil-tRNA
Proc. Natl. Acad. Sci. USA
96
14270-14275
1999
Escherichia coli
brenda
Preumont, A.; Snoussi, K.; Stroobant, V.; Collet, J.F.; Van Schaftingen, E.
Molecular identification of pseudouridine-metabolizing enzymes
J. Biol. Chem.
283
25238-25246
2008
Escherichia coli (P33025), Escherichia coli, Thermotoga maritima
brenda
Wright, J.R.; Keffer-Wilkes, L.C.; Dobing, S.R.; Kothe, U.
Pre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA, and RluA reveals uniformly slow catalysis
RNA
17
2074-2084
2011
Escherichia coli
brenda
Thapa, K.; Oja, T.; Metsae-Ketelae, M.
Molecular evolution of the bacterial pseudouridine-5-phosphate glycosidase protein family
FEBS J.
281
4439-4449
2014
Escherichia coli (P33025), Escherichia coli, Escherichia coli K12 (P33025)
brenda