Information on EC 4.2.1.48 - D-glutamate cyclase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
4.2.1.48
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RECOMMENDED NAME
GeneOntology No.
D-glutamate cyclase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glutamate = 5-oxo-D-proline + H2O
show the reaction diagram
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acylation
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intramolecular
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elimination
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-Glutamine and D-glutamate metabolism
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SYSTEMATIC NAME
IUBMB Comments
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Also acts on various derivatives of D-glutamate.
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CAS REGISTRY NUMBER
COMMENTARY hide
37290-80-5
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cis-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
show the reaction diagram
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-
-
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D,L-allo-alpha-aminotricaballylate
?
show the reaction diagram
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-
-
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D,L-alpha-aminotricaballylyate
?
show the reaction diagram
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-
-
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D,L-alpha-methlylglutamate
?
show the reaction diagram
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-
-
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D,L-beta-hydroxyglutamate
?
show the reaction diagram
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-
-
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D,L-beta-methylglutamate
?
show the reaction diagram
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-
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D,L-gamma-hydroxyglutamate
?
show the reaction diagram
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D,L-gamma-methylglutamate
?
show the reaction diagram
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-
-
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D,L-glutamate
?
show the reaction diagram
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D-alpha-methylglutamate
?
show the reaction diagram
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-
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D-gamma-methylglutamate
?
show the reaction diagram
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D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
D-glutamate
?
show the reaction diagram
-
pathway for the elimination of D-glutamate
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erythro-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
show the reaction diagram
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threo-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
show the reaction diagram
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trans-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
show the reaction diagram
-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glutamate
?
show the reaction diagram
-
pathway for the elimination of D-glutamate
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
optimal activity with 3.3 mM
Mn2+
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optimal activity with 3.3 mM
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
EDTA
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
90
5-oxo-D-proline
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200
cis-D-3-fluoro-2-pyrrolidone-5-carboxylate
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150 - 200
D-glutamate
1500
trans-D-3-fluoro-2-pyrrolidone-5-carboxylate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.8 - 8.3
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.5 - 9.4
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-196°C
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 4.2.1.48)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)