Information on EC 4.2.1.48 - D-glutamate cyclase

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The expected taxonomic range for this enzyme is: Euarchontoglires

EC NUMBER
COMMENTARY
4.2.1.48
-
RECOMMENDED NAME
GeneOntology No.
D-glutamate cyclase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
D-glutamate = 5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Acylation
-
-
intramolecular
-
elimination
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
D-Glutamine and D-glutamate metabolism
-
SYSTEMATIC NAME
IUBMB Comments
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Also acts on various derivatives of D-glutamate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
cyclase, D-glutamate
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
37290-80-5
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cis-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
show the reaction diagram
-
-
-
-
D,L-allo-alpha-aminotricaballylate
?
show the reaction diagram
-
-
-
-
-
D,L-alpha-aminotricaballylyate
?
show the reaction diagram
-
-
-
-
-
D,L-alpha-methlylglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-beta-hydroxyglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-beta-methylglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-gamma-hydroxyglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-gamma-methylglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-glutamate
?
show the reaction diagram
-
-
-
-
-
D-alpha-methylglutamate
?
show the reaction diagram
-
-
-
-
-
D-gamma-methylglutamate
?
show the reaction diagram
-
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
?
show the reaction diagram
-
pathway for the elimination of D-glutamate
-
-
-
erythro-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
show the reaction diagram
-
-
-
-
threo-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
show the reaction diagram
-
-
-
-
trans-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
show the reaction diagram
-
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glutamate
?
show the reaction diagram
-
pathway for the elimination of D-glutamate
-
-
-
METALS and IONS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
Mg2+
-
optimal activity with 3.3 mM
Mn2+
-
optimal activity with 3.3 mM
INHIBITORS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
KM VALUE [mM]
KM VALUE [mM] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
90
-
5-oxo-D-proline
-
-
200
-
cis-D-3-fluoro-2-pyrrolidone-5-carboxylate
-
-
150
-
D-glutamate
-
-
200
-
D-glutamate
-
-
1500
-
trans-D-3-fluoro-2-pyrrolidone-5-carboxylate
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
SPECIFIC ACTIVITY MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
580
-
-
-
pH OPTIMUM
pH MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
7.8
8.3
-
-
pH RANGE
pH RANGE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
6.5
9.4
-
-
STORAGE STABILITY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
-196°C
-
Purification/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE