Information on EC 4.2.1.48 - D-glutamate cyclase

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The expected taxonomic range for this enzyme is: Euarchontoglires

SplaateEC_Number,Commentary
EC NUMBER
COMMENTARY
4.2.1.48
-
SplaateRecommended_Name,GO_Number
RECOMMENDED NAME
GeneOntology No.
D-glutamate cyclase
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SplaateReaction,Reaction_id,Commentary,IF(Commentary != '',Organism,'') ,IF(Commentary != '',Literature,'')
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-glutamate = 5-oxo-D-proline + H2O
show the reaction diagram
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-
-
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SplaateReaction_Type,Organism,Commentary,Literature
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acylation
-
-
intramolecular
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elimination
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-
-
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SplaatePathway,BRENDA_Link,KEGG_Link,MetaCyc_Link,Source_Database
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
D-Glutamine and D-glutamate metabolism
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SplaateSystematic_Name,Commentary_IUBMB
SYSTEMATIC NAME
IUBMB Comments
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Also acts on various derivatives of D-glutamate.
SplaateSynonyms,Organism,Commentary,Literature
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
cyclase, D-glutamate
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-
-
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SplaateCAS_Registry_Number,Commentary
CAS REGISTRY NUMBER
COMMENTARY
37290-80-5
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SplaateOrganism, Commentary,Literature, Sequence_Code,Sequence_db,Textmining
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SplaateGeneral_Information, Organism, Commentary, Literature
SplaateSubstrates,Products,id,Organism_Substrates,Commentary_Substrates, Literature_Substrates, Commentary_Products, Literature_Products,Reversibility
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cis-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
show the reaction diagram
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-
-
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D,L-allo-alpha-aminotricaballylate
?
show the reaction diagram
-
-
-
-
-
D,L-alpha-aminotricaballylyate
?
show the reaction diagram
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-
-
-
-
D,L-alpha-methlylglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-beta-hydroxyglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-beta-methylglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-gamma-hydroxyglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-gamma-methylglutamate
?
show the reaction diagram
-
-
-
-
-
D,L-glutamate
?
show the reaction diagram
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-
-
-
-
D-alpha-methylglutamate
?
show the reaction diagram
-
-
-
-
-
D-gamma-methylglutamate
?
show the reaction diagram
-
-
-
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D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
5-oxo-D-proline + H2O
show the reaction diagram
-
-
-
-
D-glutamate
?
show the reaction diagram
-
pathway for the elimination of D-glutamate
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-
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erythro-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
show the reaction diagram
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-
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threo-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
show the reaction diagram
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trans-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
show the reaction diagram
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-
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SplaateNatural_Substrates,Natural_Products,id,Organism_Substrates,Commentary_Substrates,Literature_Substrates,Commentary_Products,Literature_Products,Reversibility
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glutamate
?
show the reaction diagram
-
pathway for the elimination of D-glutamate
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SplaateCofactor,Organism,Commentary,Literature,Filename
SplaateMetals_Ions,Organism,Commentary, Literature
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
-
optimal activity with 3.3 mM
Mn2+
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optimal activity with 3.3 mM
SplaateInhibitors, Organism, Commentary, Literature,Filename
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
EDTA
-
-
SplaateActivating_Compound, Organism, Commentary, Literature,Filename
SplaateKM_Value,KM_Value_Maximum, Substrate,Organism, Commentary, Literature, Filename
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
90
5-oxo-D-proline
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-
200
cis-D-3-fluoro-2-pyrrolidone-5-carboxylate
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-
150
D-glutamate
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200
D-glutamate
-
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1500
trans-D-3-fluoro-2-pyrrolidone-5-carboxylate
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-
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SplaateTurnover_Number, Turnover_Number_Maximum, Substrate,Organism,Commentary, Literature, Filename
SplaateKCat_KM_Value,KCat_KM_Value_Maximum, Substrate,Organism, Commentary, Literature, Filename
SplaateKI_Value,KI_Value_Maximum, Inhibitor,Organism, Commentary, Literature, Filename
SplaateIC50_Value,IC50_Value_Maximum, Inhibitor,Organism, Commentary, Literature, Filename
SplaateSpecific_Activity, Specific_Activity_Maximum, Organism ,Commentary, Literature
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SplaatepH_Optimum, pH_Optimum_Maximum, Organism, Commentary, Literature
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
7.8 - 8.3
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SplaatepH_Range,pH_Range_Maximum, Organism,Commentary, Literature
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 9.4
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-
SplaateTemperature_Optimum, Temperature_Optimum_Maximum, Organism, Commentary, Literature
SplaateTemperature_Range, Temperature_Range_Maximum, Organism, Commentary, Literature
SplaatepI_Value,pI_Value_Maximum, Organism,Commentary, Literature
SplaateSource_Tissue, Organism, Commentary, Literature, Textmining
SplaateLocalization, Organism, Commentary, id_go, Literature, Textmining
SplaatePDB,PDB,PDB,Organism,Uniprot_ID
SplaateMolecular_Weight, Molecular_Weight_Maximum, Organism, Commentary, Literature
SplaateSubunits, Organism, Commentary, Literature
SplaatePosttranslational_Modification, Organism, Commentary, Literature
SplaateCommentary, Organism, Literature
SplaatepH_Stability,pH_Stability_Maximum, Organism, Commentary, Literature
SplaateTemperature_Stability,Temperature_Stability_Maximum, Organism, Commentary, Literature
SplaateGeneral_Stability, Organism, Literature
SplaateOrganic_Solvent, Organism, Commentary, Literature
SplaateOxidation_Stability,Organism,Literature
SplaateStorage_Stability, Organism, Literature
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-196°C
-
SplaateCommentary, Organism, Literature
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
SplaateCommentary, Organism, Literature
SplaateCommentary, Organism, Literature
SplaateEngineering, Organism, Commentary, Literature
SplaateCommentary, Organism, Literature
SplaateApplication,Organism,Commentary,Literature