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Information on EC 4.2.1.48 - D-glutamate cyclase

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The enzyme appears in viruses and cellular organisms

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4.2.1.48

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D-glutamate cyclase

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D-glutamate = 5-oxo-D-proline + H2O

show the reaction diagram

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Acylation

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intramolecular

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elimination

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D-Glutamine and D-glutamate metabolism

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D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)

Also acts on various derivatives of D-glutamate.

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Show Synonyms (1 entry)

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37290-80-5

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Cavia porcellus

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Manually annotated by BRENDA team

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Manually annotated by BRENDA team

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33865, 33867, 33868, 33869, 487982

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Manually annotated by BRENDA team

Oryctolagus cuniculus

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Manually annotated by BRENDA team

Rattus norvegicus

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Manually annotated by BRENDA team

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cis-3-fluoro-2-pyrrolidone-5-carboxylate + H2O

gamma-fluoroglutamate

show the reaction diagram

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D,L-allo-alpha-aminotricaballylate

?

show the reaction diagram

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D,L-alpha-aminotricaballylyate

?

show the reaction diagram

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D,L-alpha-methlylglutamate

?

show the reaction diagram

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D,L-beta-hydroxyglutamate

?

show the reaction diagram

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D,L-beta-methylglutamate

?

show the reaction diagram

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D,L-gamma-hydroxyglutamate

?

show the reaction diagram

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D,L-gamma-methylglutamate

?

show the reaction diagram

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D,L-glutamate

?

show the reaction diagram

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D-alpha-methylglutamate

?

show the reaction diagram

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D-gamma-methylglutamate

?

show the reaction diagram

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D-glutamate

5-oxo-D-proline + H2O

show the reaction diagram

show

D-glutamate

?

show the reaction diagram

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pathway for the elimination of D-glutamate

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erythro-gamma-fluoroglutamate

3-fluoro-2-pyrrolidone-5-carboxylate + H2O

show the reaction diagram

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threo-gamma-fluoroglutamate

3-fluoro-2-pyrrolidone-5-carboxylate + H2O

show the reaction diagram

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trans-3-fluoro-2-pyrrolidone-5-carboxylate + H2O

gamma-fluoroglutamate

show the reaction diagram

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D-glutamate

?

show the reaction diagram

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pathway for the elimination of D-glutamate

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Mg2+

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optimal activity with 3.3 mM

Mn2+

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optimal activity with 3.3 mM

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EDTA

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90

5-oxo-D-proline

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200

cis-D-3-fluoro-2-pyrrolidone-5-carboxylate

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150 - 200

D-glutamate

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1500

trans-D-3-fluoro-2-pyrrolidone-5-carboxylate

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580

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7.8 - 8.3

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6.5 - 9.4

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Rattus norvegicus

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Manually annotated by BRENDA team

show

show

Rattus norvegicus

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Manually annotated by BRENDA team

skeletal muscle

Rattus norvegicus

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Manually annotated by BRENDA team

Rattus norvegicus

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Manually annotated by BRENDA team

Rattus norvegicus

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Manually annotated by BRENDA team

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Manually annotated by BRENDA team

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-196°C

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Show References (5 entries)

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NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM

IUBMB Enzyme Nomenclature

PROSITE Database of protein families and domains

Protein Mutant Database

InterPro (database of protein families, domains and functional sites)