Information on EC 4.2.1.48 - D-glutamate cyclase
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The enzyme appears in viruses and cellular organisms
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D-glutamate = 5-oxo-D-proline + H2O
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Acylation
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intramolecular
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D-Glutamine and D-glutamate metabolism
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D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Also acts on various derivatives of D-glutamate.
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cyclase, D-glutamate
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cis-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
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D,L-allo-alpha-aminotricaballylate
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D,L-alpha-aminotricaballylyate
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D,L-alpha-methlylglutamate
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D,L-beta-hydroxyglutamate
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D,L-beta-methylglutamate
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D,L-gamma-hydroxyglutamate
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D,L-gamma-methylglutamate
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D,L-glutamate
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D-alpha-methylglutamate
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D-gamma-methylglutamate
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D-glutamate
5-oxo-D-proline + H2O
D-glutamate
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pathway for the elimination of D-glutamate
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erythro-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
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threo-gamma-fluoroglutamate
3-fluoro-2-pyrrolidone-5-carboxylate + H2O
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trans-3-fluoro-2-pyrrolidone-5-carboxylate + H2O
gamma-fluoroglutamate
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D-glutamate

5-oxo-D-proline + H2O
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D-glutamate
5-oxo-D-proline + H2O
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D-glutamate
5-oxo-D-proline + H2O
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D-glutamate
5-oxo-D-proline + H2O
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D-glutamate
5-oxo-D-proline + H2O
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D-glutamate
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pathway for the elimination of D-glutamate
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Mg2+
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optimal activity with 3.3 mM
Mn2+
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optimal activity with 3.3 mM
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200
cis-D-3-fluoro-2-pyrrolidone-5-carboxylate
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1500
trans-D-3-fluoro-2-pyrrolidone-5-carboxylate
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150
D-glutamate

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low activity
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low activity
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low activity
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GLUCM_HUMAN
616
66437
Swiss-Prot
GLUCM_MOUSE
617
66366
Swiss-Prot
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Xu, T.; Meister, A.
Preparation of optically pure isotopically labeled L-glutamate
Methods Enzymol.
113
59-63
1985
Mus musculus
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Unkeless, J.C.; Goldman, P.
Thermodynamic and kinetic aspects of the reaction of gamma-fluoroglutamate with D-glutamate cyclase
J. Biol. Chem.
246
2354-2359
1971
Mus musculus
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Meister, A.
D-Glutamic acid cyclotransferase (mouse kidney, liver)
Methods Enzymol.
17A
860-863
1974
Mus musculus
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Meister, A.; Bukenberger, M.W.; Strassburger, M.
The optically-specific enzymatic cyclization of D-glutamate
Biochem. Z.
338
217-229
1963
Homo sapiens, Mus musculus
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Orlowski, M.; Meister, A.
Enzymology of pyrrolidone carboxylic acid
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
4
123-151
1971
Cavia porcellus, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus
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