Reference on EC 4.2.1.33 - 3-isopropylmalate dehydratase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gross, S.R.
Isopropylmalate isomerase (Neurospora)
Methods Enzymol.
17A
786-790
1970
Neurospora sp., Salmonella sp.
-
Bigelis, R.; Umbarger, H.E.
Yeast alpha-isopropylmalate isomerase. Factors affecting enzyme stability and enzyme activity
J. Biol. Chem.
251
3545-3552
1976
Saccharomyces cerevisiae
Reichenbecher Jr, V.E.; Gross, S.R.
Structural features of normal and complemented forms of the Neurospora isopropylmalate isomerase
J. Bacteriol.
133
802-810
1978
BRENDA: Neurospora crassa
Textmining: Neurospora
Gross, S.R.; Umbarger, H.E.
The biosynthesis of leucine: II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate
Biochemistry
2
1046-1052
1963
Neurospora crassa, Salmonella enterica subsp. enterica serovar Typhimurium
Reichenbecher, V.E.; Fischer, M.; Gross, S.R.
Regulation of isopropylmalate synthesis in Neurospora crassa
J. Bacteriol.
133
794-801
1978
Neurospora crassa
Kohlhaw, G.B.
Isopropylmalate dehydratase from yeast
Methods Enzymol.
166
423-429
1988
Saccharomyces cerevisiae
Bode, R.; Birnbaum, D.
Some properties of the leucine-biosynthesizing enzymes from Candida maltosa
J. Basic Microbiol.
31
21-26
1991
Candida maltosa
-
Irvin, S.D.; Bhattacharjee, J.K.
A unique fungal lysine biosynthesis enzyme shares a common ancestor with tricarboxylic acid cycle and leucine biosynthetic enzymes found in diverse organisms
J. Mol. Evol.
46
401-408
1998
Bacteria, Archaea, eukaryota, Fungi
Honda, H.; Kato, C.; Kudo, T.; Horikoshi, K.
Cloning of leucine genes of alkalophilic Bacillus No. 221 in E. coli and B. subtilis
J. Biochem.
95
1485-1490
1984
Escherichia coli, Bacillus subtilis, Bacillus, plasmids
Xu, H.; Zhang, Y.; Guo, X.; Ren, S.; Staempfli, A.A.; Chiao, J.; Jiang, W.; Zhao, G.
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway
J. Bacteriol.
186
5400-5409
2004
Escherichia coli, Leptospira interrogans, Spirochaetales, Archaea, Methanocaldococcus jannaschii
Hayashi, M.; Mizoguchi, H.; Ohnishi, J.; Mitsuhashi, S.; Yonetani, Y.; Hashimoto, S.; Ikeda, M.
A leuC mutation leading to increased L-lysine production and rel-independent global expression changes in Corynebacterium glutamicum
Appl. Microbiol. Biotechnol.
72
783-789
2006
Corynebacterium glutamicum, Corynebacterium glutamicum B-6
Drevland, R.M.; Waheed, A.; Graham, D.E.
Enzymology and evolution of the pyruvate pathway to 2-oxobutyrate in Methanocaldococcus jannaschii
J. Bacteriol.
189
4391-4400
2007
Methanocaldococcus jannaschii, Bacteria, Escherichia coli, Archaea, archaeon
Hamaji, T.; Ferris, P.J.; Coleman, A.W.; Waffenschmidt, S.; Takahashi, F.; Nishii, I.; Nozaki, H.
Identification of the minus-dominance gene ortholog in the mating-type locus of Gonium pectorale
Genetics
178
283-294
2008
BRENDA: Gonium pectorale
Textmining: Chlamydomonas reinhardtii
Karuppasamy, M.; Geerlof, A.; Schuldt, L.; Mueller-Dieckmann, C.; Weiss, M.S.
Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the small subunit of isopropylmalate isomerase (Rv2987c) from Mycobacterium tuberculosis
Acta Crystallogr. Sect. F
65
136-139
2009
BRENDA: Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Textmining: Escherichia coli
Jeyakanthan, J.; Drevland, R.M.; Gayathri, D.R.; Velmurugan, D.; Shinkai, A.; Kuramitsu, S.; Yokoyama, S.; Graham, D.E.
Substrate specificity determinants of the methanogen homoaconitase enzyme: structure and function of the small subunit
Biochemistry
49
2687-2696
2010
Methanocaldococcus jannaschii
Knill, T.; Reichelt, M.; Paetz, C.; Gershenzon, J.; Binder, S.
Arabidopsis thaliana encodes a bacterial-type heterodimeric isopropylmalate isomerase involved in both Leu biosynthesis and the Met chain elongation pathway of glucosinolate formation
Plant Mol. Biol.
71
227-239
2009
BRENDA: Arabidopsis thaliana (Q94AR8), Arabidopsis thaliana (Q94AR8 AND Q9ZW84), Arabidopsis thaliana (Q9LYT7), Arabidopsis thaliana (Q9ZW84), Arabidopsis thaliana (Q9ZW85), Arabidopsis thaliana, Arabidopsis thaliana Col-0 (Q94AR8 AND Q9ZW84)
Textmining: Arabidopsis
He, Y.; Chen, B.; Pang, Q.; Strul, J.M.; Chen, S.
Functional specification of Arabidopsis isopropylmalate isomerases in glucosinolate and leucine biosynthesis
Plant Cell Physiol.
51
1480-1487
2010
BRENDA: Arabidopsis thaliana
Textmining: Arabidopsis, Bacteria, Archaea
Manikandan, K.; Geerlof, A.; Zozulya, A.V.; Svergun, D.I.; Weiss, M.S.
Structural studies on the enzyme complex isopropylmalate isomerase (LeuCD) from Mycobacterium tuberculosis
Proteins
79
35-49
2011
BRENDA: Mycobacterium tuberculosis (P9WK95), Mycobacterium tuberculosis (P9WQF5), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WK95), Mycobacterium tuberculosis H37Rv (P9WQF5)
Textmining: Bacteria, Homo sapiens
Yasutake, Y.; Yao, M.; Sakai, N.; Kirita, T.; Tanaka, I.
Crystal structure of the Pyrococcus horikoshii isopropylmalate isomerase small subunit provides insight into the dual substrate specificity of the enzyme
J. Mol. Biol.
344
325-333
2004
BRENDA: Pyrococcus horikoshii (O59393), Pyrococcus horikoshii
Textmining: Archaea
Lee, E.H.; Lee, K.; Hwang, K.Y.
Structural characterization and comparison of the large subunits of IPM isomerase and homoaconitase from Methanococcus jannaschii
Acta Crystallogr. Sect. D
70
922-931
2014
BRENDA: Methanocaldococcus jannaschii (P81291), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (P81291)
Textmining: archaeon
Lee, E.H.; Cho, Y.W.; Hwang, K.Y.
Crystal structure of LeuD from Methanococcus jannaschii
Biochem. Biophys. Res. Commun.
419
160-164
2012
Methanocaldococcus jannaschii (Q58673), Methanocaldococcus jannaschii
Imhof, J.; Huber, F.; Reichelt, M.; Gershenzon, J.; Wiegreffe, C.; Laechler, K.; Binder, S.
The small subunit 1 of the Arabidopsis isopropylmalate isomerase is required for normal growth and development and the early stages of glucosinolate formation
PLoS ONE
9
e91071
2014
BRENDA: Arabidopsis thaliana
Textmining: Arabidopsis, plant
Morohoshi, T.; Kamimura, Y.; Sato, N.; Iizumi, T.
Distribution and characterization of N-acylhomoserine lactone (AHL)-degrading activity and AHL lactonase gene (qsdS) in Sphingopyxis
J. Biosci. Bioeng.
127
411-417
2018
Sphingopyxis, Sphingopyxis alaskensis, Sphingopyxis bauzanensis
Wang, J.; Yang, Y.; Zhang, R.; Shen, X.; Chen, Z.; Wang, J.; Yuan, Q.; Yan, Y.
Microbial production of branched-chain dicarboxylate 2-methylsuccinic acid via enoate reductase-mediated bioreduction
Metab. Eng.
45
1-10
2018
Escherichia coli, Bacillus subtilis (P54550), Bacillus subtilis, Methanocaldococcus jannaschii
Chen, L.Q.; Chhajed, S.; Zhang, T.; Collins, J.M.; Pang, Q.; Song, W.; He, Y.; Chen, S.
Protein complex formation in methionine chain-elongation and leucine biosynthesis
Sci. Rep.
11
3524
2021
BRENDA: Arabidopsis thaliana, Arabidopsis thaliana Col0
Textmining: Saccharomyces cerevisiae
Fultz, PN; Kwoh, DY; Kemper, J
Salmonella typhimurium newD and Escherichia coli leuC genes code for a functional isopropylmalate isomerase in Salmonella typhimurium-Escherichia coli hybrids.
J Bacteriol
137
1253-62
1979
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Bigelis, R; Umbarger, HE
Purification of yeast alpha-isopropylmalate isomerase. High ionic strength hydrophobic chromatography.
J Biol Chem
250
4315-21
1975
Saccharomyces cerevisiae
Skala, J; Capieaux, E; Balzi, E; Chen, WN; Goffeau, A
Complete sequence of the Saccharomyces cerevisiae LEU1 gene encoding isopropylmalate isomerase.
Yeast
7
281-5
1991
Saccharomyces cerevisiae
Fultz, PN; Kemper, J
Wild-type isopropylmalate isomerase in Salmonella typhimurium is composed of two different subunits.
J Bacteriol
148
210-9
1981
Salmonella enterica subsp. enterica serovar Typhimurium
Angara, RK; Yousuf, S; Gupta, SK; Ranjan, A
An IclR like protein from mycobacteria regulates leuCD operon and induces dormancy-like growth arrest in Mycobacterium smegmatis.
Tuberculosis (Edinb)
108
83-92
2018
Mycolicibacterium smegmatis, Corynebacteriales
Tang, W; Jiang, H; Zheng, Q; Chen, X; Wang, R; Yang, S; Zhao, G; Liu, J; Norvienyeku, J; Wang, Z
Isopropylmalate isomerase MoLeu1 orchestrates leucine biosynthesis, fungal development, and pathogenicity in Magnaporthe oryzae.
Appl Microbiol Biotechnol
103
327-337
2019
Pyricularia oryzae, Saccharomyces cerevisiae
Lchler, K; Clauss, K; Imhof, J; Crocoll, C; Schulz, A; Halkier, BA; Binder, S
In Arabidopsis thaliana Substrate Recognition and Tissue- as Well as Plastid Type-Specific Expression Define the Roles of Distinct Small Subunits of Isopropylmalate Isomerase.
Front Plant Sci
11
808
2020
Arabidopsis thaliana
Hsu, YP; Kohlhaw, GB; Niederberger, P
Evidence that alpha-isopropylmalate synthase of Saccharomyces cerevisiae is under the "general" control of amino acid biosynthesis.
J Bacteriol
150
969-72
1982
Saccharomyces cerevisiae
Singer, RA; Doolittle, WF
Leucine biosynthesis in the blue-green bacterium Anacystis nidulans.
J Bacteriol
124
810-4
1975
Synechococcus elongatus PCC 7942 = FACHB-805, bacterium, Cyanobacteria
Stover, CK; Kemper, J; Marsh, RC
Molecular cloning and characterization of supQ/newD, a gene substitution system for the leuD gene of Salmonella typhimurium.
J Bacteriol
170
3115-24
1988
Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli, plasmids
Bartnik, E; Bonnet-Bidaud, A; Kowalska, I; Pieniazek, NJ
New leucine auxotrophs of Aspergillus nidulans.
Acta Microbiol Pol
29
29-33
1980
Aspergillus nidulans
Castelli, P; Donadio, S; Marinelli, F; Borghi, A; Sosio, M
Complementation of a Streptomyces lividans Leu- mutant by the Actinoplanes teichomyceticus leuC gene.
Gene
158
97-100
1995
Actinoplanes teichomyceticus, Streptomyces lividans, Streptomyces
Oultram, JD; Loughlin, M; Walmsley, R; Gunnery, SM; Minton, NP
The nucleotide sequence of genes involved in the leucine biosynthetic pathway of Clostridium pasteurianum.
DNA Seq
4
105-11
1993
Salmonella enterica subsp. enterica serovar Typhimurium, Clostridium pasteurianum, Escherichia coli
Bange, FC; Brown, AM; Jacobs, WR
Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages.
Infect Immun
64
1794-9
1996
Escherichia coli, transposons, insertion sequences
Wada, M; Beppu, T; Horinouchi, S
Integrative transformation of the zygomycete Rhizomucor pusillus by homologous recombination.
Appl Microbiol Biotechnol
45
652-7
1996
Rhizomucor pusillus, Transformation, Mucor circinelloides
Craster, HL; Potter, CA; Baumberg, S
End-product control of expression of branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2): paradoxical relationships between DNA sequence and regulatory phenotype.
Microbiology
145 ( Pt 9)
2375-84
1999
Streptomyces coelicolor A3(2), Streptomyces coelicolor, Streptomycetales
Brune, I; Jochmann, N; Brinkrolf, K; Hüser, AT; Gerstmeir, R; Eikmanns, BJ; Kalinowski, J; Pühler, A; Tauch, A
The IclR-type transcriptional repressor LtbR regulates the expression of leucine and tryptophan biosynthesis genes in the amino acid producer Corynebacterium glutamicum.
J Bacteriol
189
2720-33
2007
Corynebacterium glutamicum, Bacteria, Corynebacterium diphtheriae, Mycobacterium tuberculosis variant bovis, Corynebacterium jeikeium, Actinobacteria, Bifidobacterium longum
Santamarta, I; López-García, MT; Pérez-Redondo, R; Koekman, B; Martín, JF; Liras, P
Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.
Mol Microbiol
66
511-24
2007
Streptomyces clavuligerus
Albrecht, AG; Netz, DJ; Miethke, M; Pierik, AJ; Burghaus, O; Peuckert, F; Lill, R; Marahiel, MA
SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis.
J Bacteriol
192
1643-51
2010
Bacillus subtilis, Bacteria, Escherichia coli
Kochevenko, A; Fernie, AR
The genetic architecture of branched-chain amino acid accumulation in tomato fruits.
J Exp Bot
2011
plant, Solanum lycopersicum, Solanum pennellii
Kim, SH; Lee, BR; Kim, JN; Kim, BG
NdgR, a common transcriptional activator for methionine and leucine biosynthesis in Streptomyces coelicolor.
J Bacteriol
194
6837-46
2012
Actinomycetia, Streptomyces coelicolor, Streptomyces
Carlsen, S; Ajikumar, PK; Formenti, LR; Zhou, K; Phon, TH; Nielsen, ML; Lantz, AE; Kielland-Brandt, MC; Stephanopoulos, G
Heterologous expression and characterization of bacterial 2-C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae.
Appl Microbiol Biotechnol
97
5753-69
2013
Saccharomyces cerevisiae
Park, YM; Lee, HJ; Jeong, JH; Kook, JK; Choy, HE; Hahn, TW; Bang, IS
Branched-chain amino acid supplementation promotes aerobic growth of Salmonella Typhimurium under nitrosative stress conditions.
Arch Microbiol
2015
Salmonella enterica subsp. enterica serovar Typhimurium
Crocoll, C; Mirza, N; Reichelt, M; Gershenzon, J; Halkier, BA
Optimization of Engineered Production of the Glucoraphanin Precursor Dihomomethionine in Nicotiana benthamiana.
Front Bioeng Biotechnol
4
14
2016
Nicotiana benthamiana
Chang, D; Yu, Z; Ul Islam, Z; French, WT; Zhang, Y; Zhang, H
Proteomic and metabolomic analysis of the cellular biomarkers related to inhibitors tolerance in Zymomonas mobilis ZM4.
Biotechnol Biofuels
11
283
2018
Zymomonas mobilis
Que, Y; Yue, X; Yang, N; Xu, Z; Tang, S; Wang, C; Lv, W; Xu, L; Talbot, NJ; Wang, Z
Leucine biosynthesis is required for infection-related morphogenesis and pathogenicity in the rice blast fungus Magnaporthe oryzae.
Curr Genet
2019
Methylobacterium oryzae
Muramatsu, R; Misawa, S; Hayashi, H
Finding of an isoleucine derivative of a recombinant protein for pharmaceutical use.
J Pharm Biomed Anal
31
979-87
2003
Escherichia coli
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