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Information on EC 4.2.1.30 - glycerol dehydratase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.30 glycerol dehydratase
IUBMB Comments
Two different forms of the enzyme have been described. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.
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This record set is specific for:
UNIPROT: Q8GEZ8
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
glycerol dehydratase, b12-dependent glycerol dehydratase, dhab1, glycerol dehydrase, dhabce, b12-independent glycerol dehydratase, kpgdht, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
B12-independent GDH
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vitamin B12-independent glycerol dehydratase
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dehydratase, glycerol
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-
-
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glycerol dehydrase
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-
-
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glycerol hydrolyase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
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-
-
-
PATHWAY SOURCE
PATHWAYS
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-, -
SYSTEMATIC NAME
IUBMB Comments
glycerol hydro-lyase (3-hydroxypropanal-forming)
Two different forms of the enzyme have been described. One form requires a cobamide coenzyme, while the other is a glycyl radical enzyme.
CAS REGISTRY NUMBER
COMMENTARY hide
9077-68-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glycerol
3-hydroxypropanal + H2O
show the reaction diagram
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-
-
?
glycerol
?
show the reaction diagram
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-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
glycerol
3-hydroxypropanal + H2O
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q8GEZ8_CLOBU
787
0
88047
TrEMBL
Secretory Pathway (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
1,3-propanediol operon of dhaB1 (encodes the vitamin B12-independent glycerol dehydratase), dhaB2 (encodes the activating factor of DhaB1) tandemly arrayed with Escherichia coli yqhD gene (encodes 1,3-propanediol oxidoreductase) under the control of a constitutive, temperature-sensitive promoter, in the vector pBV220 for heterologous expression in Escherichia coli K-12 ER2925
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
biotechnology
development of an economical and eco-friendly biological process for the production of 1,3-propanediol by an operon harboring the dhaB1, dhaB2, and yqhD genes, from renewable resources
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tang, X.; Tan, Y.; Zhu, H.; Zhao, K.; Shen, W.
Microbial conversion of glycerol to 1,3-propanediol by an engineered strain of Escherichia coli
Appl. Environ. Microbiol.
75
1628-1634
2009
Clostridium butyricum (Q8GEZ8), Clostridium butyricum
Manually annotated by BRENDA team
Feliks, M.; Ullmann, G.M.
Glycerol dehydratation by the B12-independent enzyme may not involve the migration of a hydroxyl group: a computational study
J. Phys. Chem. B
116
7076-7087
2012
Clostridium butyricum (Q8GEZ8)
Manually annotated by BRENDA team