Reference on EC 4.2.1.3 - aconitate hydratase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pickworth Glusker, J.
Aconitase
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
413-439
1971
Aspergillus niger, Bacillus subtilis, Bos taurus, Saccharomyces cerevisiae, Oryctolagus cuniculus, Glycine max, Rattus norvegicus, Rheum sp., Salmonella enterica subsp. enterica serovar Typhimurium, Sinapis alba, Solanum tuberosum, Sus scrofa
-
Gruer, M.J.; Bradbury, A.J.; Guest, J.R.
Construction and properties of aconitase mutants of Escherichia coli
Microbiology
143
1837-1846
1997
Escherichia coli
Brouquisse, R.; Nishimura, M.; Gaillard, J.; Douce, R.
Characterization of a cytosolic aconitase in higher plant cells
Plant Physiol.
84
1402-1407
1987
Acer pseudoplatanus
Dingman, D.W.; Sonenshein, A.L.
Purification of aconitase from Bacillus subtilis and correlation of its N-terminal amino acid sequence with the sequence of the citB gene
J. Bacteriol.
169
3062-3067
1987
Bacillus subtilis
Schloss, J.V.; Emptage, M.H.; Cleland, W.W.
pH profiles and isotope effects for aconitases from Saccharomycopsis lipolytica, beef heart, and beef liver. alpha-Methyl-cis-aconitate and threo-Ds-alpha-methylisocitrate as substrates
Biochemistry
23
4572-4580
1984
Bos taurus, Saccharomycopsis lipolytica
Scholze, H.
Studies on aconitase species from Saccharomyces cerevisiae, porcine and bovine heart, obtained by a modified isolation method
Biochim. Biophys. Acta
746
133-137
1983
Bos taurus, Saccharomyces cerevisiae, Sus scrofa
Treton, B.; Heslot, H.
Etude de quelques proprietes de l'aconitase de la levure Saccharomycopsis lipolytica
Agric. Biol. Chem.
42
1201-1206
1978
Saccharomycopsis lipolytica
-
Agrawal, P.K.; Garg, G.K.; Gollakota, K.G.
Studies on two isozymes of aconitase from Bacillus cereus T. III. Enzymatic properties
Biochem. Biophys. Res. Commun.
70
987-996
1976
Bacillus cereus
Agrawal, P.K.; Garg, G.K.; Gollakota, K.G.
Studies on two isozymes of aconitase from Bacillus cereus T. II. Further evidence on two distinct activities
Biochem. Biophys. Res. Commun.
70
979-986
1976
Bacillus cereus, Bacillus cereus T
Agrawal, P.K.; Garg, G.K.; Gollakota, K.G.
Studies on two isozymes of aconitase from Bacillus cereus T. I. Partial purification and stability
Biochem. Biophys. Res. Commun.
67
645-652
1975
Bacillus cereus, Bacillus cereus T
Suzuki, T.; Yamazaki, O.; Nara, K.; Akiyama, S.; Nakao, Y.; Fukuda, H.
The aconitase of yeast. II. Crystallization and general properties of yeast aconitase
J. Biochem.
77
367-372
1975
Yarrowia lipolytica
Suzuki, T.; Akiyama, S.; Fujimoto, S.; Ishikawa, M.; Nakao, Y.; Fukuda, H.
The aconitase of yeast. IV. Studies on iron and sulfur in yeast aconitase
J. Biochem.
80
799-804
1976
Yarrowia lipolytica
Gawron, O.; Kennedy, M.C.; Rauner, R.A.
Properties of pig heart aconitase
Biochem. J.
143
717-722
1974
Yarrowia lipolytica, Sus scrofa
Guarriero-Bobyleva, V.; Volpi-Becchi, M.A.; Masini, A.
Parallel partial purification of cytoplasmic and mitochondrial aconitate hydratases from rat liver
Eur. J. Biochem.
34
455-458
1973
Rattus norvegicus
Robbins, A.H.; Stout, C.D.
Iron-sulfur cluster in aconitase. Crystallographic evidence for a three-iron center
J. Biol. Chem.
260
2328-2333
1985
Sus scrofa
Ramsay, R.R.; Singer, T.P.
Molecular forms of aconitase and their interconversions
Biochem. J.
221
489-497
1984
Bos taurus
Ryden, L.; Ofverstedt, L.G.; Beinert, H.; Emptage, M.H.; Kennedy, M.C.
Molecular weight of beef heart aconitase and stoichiometry of the components of its iron-sulfur cluster
J. Biol. Chem.
259
3141-3144
1984
Bos taurus
Robbins, A.H.; Stout, C.D.; Piszkiewicz, D.; Gawron, O.; Yoo, C.S.; Wang, B.C.; Sax, M.
Single crystals of the iron-sulfur enzyme aconitase
J. Biol. Chem.
257
9061-9063
1982
Sus scrofa
Lee, J.; Chang, S.C.; Hahm, K.; Glaid, A.J.; Gawron, O.; Wang, B.C.; Yoo, C.S.; Sax, M.
Crystals of pig heart aconitase
J. Mol. Biol.
112
531-534
1977
Sus scrofa
Suzuki, T.; Yamazaki, O.; Nara, K.; Akiyama, S.; Nakao, Y.; Fukuda, H.
Crystallization and reconstitution of yeast aconitase
Agric. Biol. Chem.
37
2211-2212
1973
Yarrowia lipolytica
-
Hattori, Y.; Hino, S.
Inactivation by oxygen and stabilization by fluorocitrate of aconitase from Escherichia coli
J. Gen. Appl. Microbiol.
27
33-41
1981
Escherichia coli
-
Kennedy, S.C.; Rauner, R.; Gawron, O.
On pig heart aconitase
Biochem. Biophys. Res. Commun.
47
740-745
1972
Sus scrofa
Suzuki, T.; Akiyama, S.; Yamazaki, O.; Nara, K.; Nakao, Y.; Fukuda, H.
Induction and stabilization of yeast aconitase activity by fluorocitrate
Agric. Biol. Chem.
39
97-103
1975
Corynebacterium glutamicum, Yarrowia lipolytica, Trametes sanguinea, Streptomyces aureus, Xanthomonas campestris, Corynebacterium glutamicum D-248
-
Lauble, H.; Kennedy, M.C.; Emptage, M.H.; Beinert, H.; Stout, C.D.
The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex
Proc. Natl. Acad. Sci. USA
93
13699-13703
1996
Bos taurus
Zheng, W.; Ren, S.; Graziano, J.H.
Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity
Brain Res.
799
334-342
1998
Rattus norvegicus
De Bellis, L.; Tsugeki, R.; Alpi, A.; Nishimura, M.
Purification and characterization of aconitase isoforms from etiolated pumpkin cotyledons
Physiol. Plant.
99
485-492
1993
Cucurbita sp.
-
Costello, L.C.; Liu, Y.; Franklin, R.B.; Kennedy, M.C.
Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells
J. Biol. Chem.
272
28875-28881
1997
Bos taurus, Rattus norvegicus, Sus scrofa
Kennedy, M.C.; Mende-Mueller, L.; Blondin, G.A.; Beinert, H.
Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein [published erratum appears in Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2556
Proc. Natl. Acad. Sci. USA
89
11730-11734
1992
Bos taurus
Bennett, B.; Gruer, M.J.; Guest, J.R.; Thomson, A.J.
Spectroscopic characterisation of an aconitase (AcnA) of Escherichia coli
Eur. J. Biochem.
233
317-326
1995
Escherichia coli
Zheng, L.; Andrews, P.C.; Hermodson, M.A.; Dixon, J.E.; Zalkin, H.
Cloning and structural characterization of porcine heart aconitase
J. Biol. Chem.
265
2814-2821
1990
Sus scrofa
Prodromou, C.; Haynes, M.J.; Guest, J.R.
The aconitase of Escherichia coli: purification of the enzyme and molecular cloning and map location of the gene (acn)
J. Gen. Microbiol.
137
2505-2515
1991
Escherichia coli
Cheung, P.Y.; Danial, H.; Jong, J.; Schulz, R.
Thiols protect the inhibition of myocardial aconitase by peroxynitrite
Arch. Biochem. Biophys.
350
104-108
1988
Rattus norvegicus
Somerville, G.; Mikoryak, C.A.; Reitzer, L.
Physiological characterization of Pseudomonas aeruginosa during exotoxin A synthesis: glutamate, iron limitation, and aconitase activity
J. Bacteriol.
181
1072-1078
1999
Pseudomonas aeruginosa
Baldwin, G.S.; Seet, K.L.; Callaghan, J.; Toncich, G.; Toh, B.H.; Moritz, R.L.; Rubira, M.R.; Simpson, R.
Purification and partial amino acid sequence of human aconitase
Protein Seq. Data Anal.
4
63-67
1991
Homo sapiens, Sus scrofa
Brock, M.; Maerker, C.; Schuetz, A.; Voelker, U.; Buckel, W.
Oxidation of propionate to pyruvate in Escherichia coli: Involvement of methylcitrate dehydratase and aconitase
Eur. J. Biochem.
269
6184-6194
2002
Escherichia coli (P36683), Escherichia coli, Escherichia coli W3350 (P36683)
Muschko, K.; Kienzlen, G.; Fiedler, H.P.; Wohlleben, W.; Schwartz, D.
Tricarboxylic acid cycle aconitase activity during the life cycle of Streptomyces viridochromogenesTu494
Arch. Microbiol.
178
499-505
2002
Streptomyces viridochromogenes, Streptomyces viridochromogenes DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494
/ Tu 494
Rzymkiewicz, D.M.; Reddan, J.R.; Andley, U.P.
Induction of heme oxygenase-1 modulates cis-aconitase activity in lens epithelial cells
Biochem. Biophys. Res. Commun.
270
324-328
2000
Homo sapiens
Ho, K.P.; Xiao, D.S.; Ke, Y.; Qian, Z.M.
Exercise decreases cytosolic aconitase activity in the liver, spleen, and bone marrow in rats
Biochem. Biophys. Res. Commun.
282
264-267
2001
Rattus norvegicus
Jordan, P.A.; Tang, Y.; Bradbury, A.J.; Thomson, A.J.; Guest, J.R.
Biochemical and spectroscopic characterization of Escherichia coli aconitases (AcnA and AcnB)
Biochem. J.
344
739-746
1999
Escherichia coli, Escherichia coli JRG2387
-
Uhrigshardt, H.; Zoske, S.; Anemuller, S.
Sulfolobus aconitase, a regulator of iron metabolism?
Biochem. Soc. Trans.
30
685-687
2002
Saccharolobus solfataricus
James, E.A.; Gygi, S.P.; Adams, M.L.; Pierce, R.H.; Fausto, N.; Aebersold, R.H.; Nelson, S.D.; Bruschi, S.A.
Mitochondrial aconitase modification, functional inhibition, and evidence for a supramolecular complex of the TCA cycle by the renal toxicant S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
Biochemistry
41
6789-6797
2002
Rattus norvegicus (Q9ER34), Rattus norvegicus Male Fischer 344 (Q9ER34)
Bulteau, A.L.; Ikeda-Saito, M.; Szweda, L.I.
Redox-dependent modulation of aconitase activity in intact mitochondria
Biochemistry
42
14846-14855
2003
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Eprintsev, A.T.; Semenova, E.V.; Popov, V.N.
Induction of aconitate hydratase in hepatocytes of starving rats
Biochemistry (Moscow)
67
795-801
2002
Rattus rattus
Uhrigshardt, H.; Walden, M.; John, H.; Anemuller, S.
Purification and characterization of the first archaeal aconitase from the thermoacidophilic Sulfolobus acidocaldarius
Eur. J. Biochem.
268
1760-1771
2001
Sulfolobus acidocaldarius
Gehring, N.H.; Hentze, M.W.; Pantopoulos, K.
Inactivation of both RNA binding and aconitase activities of iron regulatory protein-1 by quinone-induced oxidative stress
J. Biol. Chem.
274
6219-6225
1999
Mus musculus
Saas, J.; Ziegelbauer, K.; von Haeseler, A.; Fast, B.; Boshart, M.
A developmentally regulated aconitase related to iron-regulatory protein-1 is localized in the cytoplasm and in the mitochondrion of Trypanosoma brucei
J. Biol. Chem.
275
2745-2755
2000
Trypanosoma brucei (Q9NJQ8), Trypanosoma brucei (Q9NJQ9), Trypanosoma brucei
Gourley, B.L.; Parker, S.B.; Jones, B.J.; Zumbrennen, K.B.; Leibold, E.A.
Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans
J. Biol. Chem.
278
3227-3234
2003
Caenorhabditis elegans (Q23500), Caenorhabditis elegans
Williams, C.H.; Stillman, T.J.; Barynin, V.V.; Sedelnikova, S.E.; Tang, Y.; Green, J.; Guest, J.R.; Artymiuk, P.J.
E. coli aconitase B structure reveals a HEAT-like domain with implications for protein-protein recognition
Nat. Struct. Biol.
9
447-452
2002
Escherichia coli (P36683), Escherichia coli
Cots, J.; Widmer, F.
Germination, senescence and pathogenic attack in soybean (Glycine max. L.): identification of the cytosolic aconitase participating in the glyoxylate cycle
Plant Sci.
149
95-104
1999
Glycine max
-
Alen, C.; Sonenshein, A.L.
Bacillus subtilis aconitase is an RNA-binding protein
Proc. Natl. Acad. Sci. USA
96
10412-10417
1999
Bacillus subtilis
Baughn, A.D.; Malamy, M.H.
A mitochondrial-like aconitase in the bacterium Bacteroides fragilis: implications for the evolution of the mitochondrial Krebs cycle
Proc. Natl. Acad. Sci. USA
99
4662-4667
2002
Bacteroides fragilis (Q8RP87), Bacteroides fragilis
Lloyd, S.J.; Lauble, H.; Prasad, G.S.; Stout, C.D.
The mechanism of aconitase:1.8 A resolution crystal structure of the S642A:citrate complex
Protein Sci.
8
2655-2662
1999
Sus scrofa (P16276)
Dupuy, J.; Darnault, C.; Brazzolotto, X.; Kuehn, L.C.; Moulis, J.M.; Volbeda, A.; Fontecilla-Camps, J.C.
Crystallization and preliminary x-ray diffraction data for the aconitase form of human iron-regulatory protein 1
Acta Crystallogr. Sect. F
F61
482-485
2005
Homo sapiens
Ilangovan, G.; Venkatakrishnan, C.D.; Bratasz, A.; Osinbowale, S.; Cardounel, A.J.; Zweier, J.L.; Kuppusamy, P.
Heat shock-induced attenuation of hydroxyl radical generation and mitochondrial aconitase activity in cardiac H9c2 cells
Am. J. Physiol.
290
C313-324
2006
Rattus norvegicus
Mitchell, C.G.
Identification of a multienzyme complex of the tricarboxylic acid cycle enzymes containing citrate synthase isoenzymes from pseudomonas aeruginosa
Biochem. J.
313
769-774
1996
Pseudomonas aeruginosa
-
Fillebeen, C.; Caltagirone, A.; Martelli, A.; Moulis, J.M.; Pantopoulos, K.
IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities
Biochem. J.
388
143-150
2005
Homo sapiens
Andreeshcheva, E.M.; Popova, T.N.; Artyukhov, V.G.; Matasova, L.V.
Free radical oxidation and catalytic activity of aconitate hydratase in rat liver under normal conditions and during toxic hepatitis
Bull. Exp. Biol. Med.
137
352-354
2004
Rattus rattus
Sreedhar, B.; Nair, K.M.
Iron dependence and zinc inhibition of duodenal cytosolic aconitase of rat
Indian J. Biochem. Biophys.
41
250-253
2004
Rattus norvegicus
Hodges, M.; Yikilmaz, E.; Patterson, G.; Kasvosve, I.; Rouault, T.A.; Gordeuk, V.R.; Loyevsky, M.
An iron regulatory-like protein expressed in Plasmodium falciparum displays aconitase activity
Mol. Biochem. Parasitol.
143
29-38
2005
Plasmodium falciparum
Regev-Rudzki, N.; Karniely, S.; Ben-Haim, N.N.; Pines, O.
Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing
Mol. Biol. Cell
16
4163-4171
2005
Saccharomyces cerevisiae
Juang, H.H.
Modulation of iron on mitochondrial aconitase expression in human prostatic carcinoma cells
Mol. Cell. Biochem.
265
185-194
2004
Homo sapiens
Tang, Y.; Guest, J.R.; Artymiuk, P.J.; Green, J.
Switching aconitase B between catalytic and regulatory modes involves iron-dependent dimer formation
Mol. Microbiol.
56
1149-1158
2005
Escherichia coli
Pitula, J.S.; Deck, K.M.; Clarke, S.L.; Anderson, S.A.; Vasanthakumar, A.; Eisenstein, R.S.
Selective inhibition of the citrate-to-isocitrate reaction of cytosolic aconitase by phosphomimetic mutation of serine-711
Proc. Natl. Acad. Sci. USA
101
10907-10912
2004
Homo sapiens
Zhang, S.; Sandstroem, M.E.; Lanner, J.T.; Thorell, A.; Westerblad, H.; Katz, A.
Activation of aconitase in mouse fast-twitch skeletal muscle during contraction-mediated oxidative stress
Am. J. Physiol.
293
C1154-C1159
2007
Homo sapiens, Mus musculus
Mason, K.E.; Stofan, D.A.
Endotoxin challenge reduces aconitase activity in myocardial tissue
Arch. Biochem. Biophys.
469
151-156
2008
Rattus norvegicus
Arnaud, N.; Ravet, K.; Borlotti, A.; Touraine, B.; Boucherez, J.; Fizames, C.; Briat, J.F.; Cellier, F.; Gaymard, F.
The iron-responsive element (IRE)/iron-regulatory protein 1 (IRP1)-cytosolic aconitase iron-regulatory switch does not operate in plants
Biochem. J.
405
523-531
2007
Arabidopsis thaliana
Unciuleac, M.C.; Chandramouli, K.; Naik, S.; Mayer, S.; Huynh, B.H.; Johnson, M.K.; Dean, D.R.
In vitro activation of apo-aconitase using a [4Fe-4S] cluster-loaded form of the IscU [Fe-S] cluster scaffolding protein
Biochemistry
46
6812-6821
2007
Azotobacter vinelandii
Sanni, B.; Williams, K.; Sokolov, E.P.; Sokolova, I.M.
Effects of acclimation temperature and cadmium exposure on mitochondrial aconitase and LON protease from a model marine ectotherm, Crassostrea virginica
Comp. Biochem. Physiol. C
147
101-112
2008
Crassostrea virginica
Tortora, V.; Quijano, C.; Freeman, B.; Radi, R.; Castro, L.
Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation
Free Radic. Biol. Med.
42
1075-1088
2007
Sus scrofa
Gupta, P.; Aggarwal, N.; Batra, P.; Mishra, S.; Chaudhuri, T.K.
Co-expression of chaperonin GroEL/GroES enhances in vivo folding of yeast mitochondrial aconitase and alters the growth characteristics of Escherichia coli
Int. J. Biochem. Cell Biol.
38
1975-1985
2006
Saccharomyces cerevisiae
Lall, M.M.; Ferrell, J.; Nagar, S.; Fleisher, L.N.; McGahan, M.C.
Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase
Invest. Ophthalmol. Vis. Sci.
49
310-319
2008
Canis lupus familiaris
Serio, A.W.; Pechter, K.B.; Sonenshein, A.L.
Bacillus subtilis aconitase is required for efficient late-sporulation gene expression
J. Bacteriol.
188
6396-6405
2006
Bacillus subtilis
Serio, A.W.; Sonenshein, A.L.
Expression of yeast mitochondrial aconitase in Bacillus subtilis
J. Bacteriol.
188
6406-6410
2006
Saccharomyces cerevisiae
Banerjee, S.; Nandyala, A.K.; Raviprasad, P.; Ahmed, N.; Hasnain, S.E.
Iron-dependent RNA-binding activity of Mycobacterium tuberculosis aconitase
J. Bacteriol.
189
4046-4052
2007
Mycobacterium tuberculosis
Lind, M.I.; Missirlis, F.; Melefors, O.; Uhrigshardt, H.; Kirby, K.; Phillips, J.P.; Soederhaell, K.; Rouault, T.A.
Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein
J. Biol. Chem.
281
18707-18714
2006
Drosophila melanogaster (Q9NFX2), Drosophila melanogaster (Q9NFX3), Drosophila melanogaster
Cherkasov, A.A.; Overton, R.A.; Sokolov, E.P.; Sokolova, I.M.
Temperature-dependent effects of cadmium and purine nucleotides on mitochondrial aconitase from a marine ectotherm, Crassostrea virginica: a role of temperature in oxidative stress and allosteric enzyme regulation
J. Exp. Biol.
210
46-55
2007
Crassostrea virginica
Crooks, D.R.; Ghosh, M.C.; Braun-Sommargren, M.; Rouault, T.A.; Smith, D.R.
Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells
J. Neurosci. Res.
85
1797-1809
2007
Rattus norvegicus
Hunzinger, C.; Wozny, W.; Schwall, G.P.; Poznanovic, S.; Stegmann, W.; Zengerling, H.; Schoepf, R.; Groebe, K.; Cahill, M.A.; Osiewacz, H.D.; Jaegemann, N.; Bloch, M.; Dencher, N.A.; Krause, F.; Schrattenholz, A.
Comparative profiling of the mammalian mitochondrial proteome: multiple aconitase-2 isoforms including N-formylkynurenine modifications as part of a protein biomarker signature for reactive oxidative species
J. Proteome Res.
5
625-633
2006
Bos taurus
Yarian, C.S.; Toroser, D.; Sohal, R.S.
Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice
Mech. Ageing Dev.
127
79-84
2006
Mus musculus
Singh, K.K.; Desouki, M.M.; Franklin, R.B.; Costello, L.C.
Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
Mol. Cancer
5
14
2006
Homo sapiens
Moeder, W.; Del Pozo, O.; Navarre, D.A.; Martin, G.B.; Klessig, D.F.
Aconitase plays a role in regulating resistance to oxidative stress and cell death in Arabidopsis and Nicotiana benthamiana
Plant Mol. Biol.
63
273-287
2007
Arabidopsis thaliana, Nicotiana benthamiana
Chen, X.J.; Wang, X.; Butow, R.A.
Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA
Proc. Natl. Acad. Sci. USA
104
13738-13743
2007
Saccharomyces cerevisiae
Dupuy, J.; Volbeda, A.; Carpentier, P.; Darnault, C.; Moulis, J.; Fontecilla-Camps, J.C.
Crystal structure of human iron regulatory protein 1 as cytosolic aconitase
Structure
14
129-139
2006
Homo sapiens (P21399), Homo sapiens
Lin, A.P.; Hakala, K.W.; Weintraub, S.T.; McAlister-Henn, L.
Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase
Arch. Biochem. Biophys.
474
205-212
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae MMY011
Wuebbeler, J.H.; Bruland, N.; Kretschmer, K.; Steinbuechel, A.
Novel pathway for catabolism of the organic sulfur compound 3,3-dithiodipropionic acid via 3-mercaptopropionic acid and 3-Sulfinopropionic acid to propionyl-coenzyme A by the aerobic bacterium Tetrathiobacter mimigardefordensis strain DPN7
Appl. Environ. Microbiol.
74
4028-4035
2008
Advenella mimigardefordensis (B3TZE0), Advenella mimigardefordensis, Advenella mimigardefordensis DPN7T (B3TZE0)
Holz, M.; Foerster, A.; Mauersberger, S.; Barth, G.
Aconitase overexpression changes the product ratio of citric acid production by Yarrowia lipolytica
Appl. Microbiol. Biotechnol.
81
1087-1096
2009
Yarrowia lipolytica
Tsuchiya, D.; Shimizu, N.; Tomita, M.
Cooperativity of two active sites in bacterial homodimeric aconitases
Biochem. Biophys. Res. Commun.
379
485-488
2009
Escherichia coli (P25516), Escherichia coli (P36683), Escherichia coli
Makeeva, A.V.; Popova, T.N.; Matasova, L.V.; Yama, I.N.
Effects of lipoic acid on citrate content, aconitate hydratase activity, and oxidative status during myocardial ischemia in rats
Biochemistry (Moscow)
73
76-79
2008
Rattus norvegicus
Matasova, L.V.; Popova, T.N.
Aconitate hydratase of mammals under oxidative stress
Biochemistry (Moscow)
73
957-964
2008
Homo sapiens, Homo sapiens (P21399), Mus musculus, Mus musculus (P28271), Rattus norvegicus, Rattus norvegicus (Q63270)
Tsuchiya, D.; Shimizu, N.; Tomita, M.
Versatile architecture of a bacterial aconitase B and its catalytic performance in the sequential reaction coupled with isocitrate dehydrogenase
Biochim. Biophys. Acta
1784
1847-1856
2008
Escherichia coli (P36683)
Goncalves, S.; Paupe, V.; Dassa, E.P.; Rustin, P.
Deferiprone targets aconitase: implication for Friedreich's ataxia treatment
BMC Neurol.
8
20
2008
Homo sapiens
Lin, G.; Brownsey, R.W.; Macleod, K.M.
Regulation of mitochondrial aconitase by phosphorylation in diabetic rat heart
Cell. Mol. Life Sci.
66
919-932
2009
Rattus norvegicus (Q9ER34)
Maity, P.; Bindu, S.; Dey, S.; Goyal, M.; Alam, A.; Pal, C.; Mitra, K.; Bandyopadhyay, U.
Indomethacin, a non-steroidal anti-inflammatory drug, develops gastropathy by inducing reactive oxygen species-mediated mitochondrial pathology and associated apoptosis in gastric mucosa: a novel role of mitochondrial aconitase oxidation
J. Biol. Chem.
284
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2009
Rattus norvegicus
Clore, A.M.; Doore, S.M.; Tinnirello, S.M.
Increased levels of reactive oxygen species and expression of a cytoplasmic aconitase/iron regulatory protein 1 homology during the early response of maize pulvini to gravistimulation
Plant Cell Environ.
31
144-158
2008
Zea mays
Bullock, G.C.; Delehanty, L.L.; Talbot, A.L.; Gonias, S.L.; Tong, W.H.; Rouault, T.A.; Dewar, B.; Macdonald, J.M.; Chruma, J.J.; Goldfarb, A.N.
Iron control of erythroid development by a novel aconitase-associated regulatory pathway
Blood
116
97-108
2010
Homo sapiens (P21399), Homo sapiens (Q99798), Homo sapiens
Condo, I.; Malisan, F.; Guccini, I.; Serio, D.; Rufini, A.; Testi, R.
Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin
Hum. Mol. Genet.
19
1221-1229
2010
Homo sapiens
Gupta, P.; Mishra, S.; Chaudhuri, T.K.
Reduced stability and enhanced surface hydrophobicity drive the binding of apo-aconitase with GroEL during chaperone assisted refolding
Int. J. Biochem. Cell Biol.
42
683-692
2010
Saccharomyces cerevisiae
Koziol, U.; Hannibal, L.; Rodriguez, M.C.; Fabiano, E.; Kahn, M.L.; Noya, F.
Deletion of citrate synthase restores growth of Sinorhizobium meliloti 1021 aconitase mutants
J. Bacteriol.
191
7581-7586
2009
Sinorhizobium meliloti
Gupta, P.; Ghosalkar, A.; Mishra, S.; Chaudhuri, T.K.
Enhancement of over expression and chaperone assisted yield of folded recombinant aconitase in Escherichia coli in bioreactor cultures
J. Biosci. Bioeng.
107
102-107
2009
Saccharomyces cerevisiae
Cantu, D.; Schaack, J.; Patel, M.
Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures
PLoS ONE
4
e7095
2009
Rattus norvegicus (Q9ER34)
Terol, J.; Soler, G.; Talon, M.; Cercos, M.
The aconitate hydratase family from Citrus
BMC Plant Biol.
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222
2010
Citrus clementina (D3GQL0), Citrus clementina (D3GQL1), Citrus clementina (D3GQL2)
Brito, W.d.e..A.; Rezende, T.C.; Parente, A.F.; Ricart, C.A.; Sousa, M.V.; Bao, S.N.; Soares, C.M.
Identification, characterization and regulation studies of the aconitase of Paracoccidioides brasiliensis
Fungal Biol.
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697-707
2011
Paracoccidioides brasiliensis, Paracoccidioides brasiliensis ATCC MYA 826
Baumgart, M.; Bott, M.
Biochemical characterisation of aconitase from Corynebacterium glutamicum
J. Biotechnol.
154
163-170
2011
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
Ben-Menachem, R.; Regev-Rudzki, N.; Pines, O.
The aconitase C-terminal domain is an independent dual targeting element
J. Mol. Biol.
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2011
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Gao, W.; Dai, S.; Liu, Q.; Xu, H.; Bai, Y.; Qiao, M.
Effect of site-directed mutagenesis of citB on the expression and activity of Bacillus subtilis aconitase
Mikrobiologiia
79
774-778
2011
Bacillus subtilis, Bacillus subtilis NK1010
Degu, A.; Hatew, B.; Nunes-Nesi, A.; Shlizerman, L.; Zur, N.; Katz, E.; Fernie, A.R.; Blumwald, E.; Sadka, A.
Inhibition of aconitase in Citrus fruit callus results in a metabolic shift towards amino acid biosynthesis
Planta
234
501-513
2011
Citrus limon
Michta, E.; Schad, K.; Blin, K.; Ort-Winklbauer, R.; Roettig, M.; Kohlbacher, O.; Wohlleben, W.; Schinko, E.; Mast, Y.
The bifunctional role of aconitase in Streptomyces viridochromogenes Tue494
Environ. Microbiol.
14
3203-3219
2012
Streptomyces viridochromogenes
Scandroglio, F.; Tortora, V.; Radi, R.; Castro, L.
Metabolic control analysis of mitochondrial aconitase: influence over respiration and mitochondrial superoxide and hydrogen peroxide production
Free Radic. Res.
48
684-693
2014
Rattus norvegicus
Pechter, K.B.; Meyer, F.M.; Serio, A.W.; Stuelke, J.; Sonenshein, A.L.
Two roles for aconitase in the regulation of tricarboxylic acid branch gene expression in Bacillus subtilis
J. Bacteriol.
195
1525-1537
2013
Bacillus subtilis
Austin, C.M.; Maier, R.J.
Aconitase-mediated posttranscriptional regulation of Helicobacter pylori peptidoglycan deacetylase
J. Bacteriol.
195
5316-5322
2013
Helicobacter pylori
Baothman, O.A.; Rolfe, M.D.; Green, J.
Characterization of Salmonella enterica serovar Typhimurium aconitase A
Microbiology
159
1209-1216
2013
Salmonella enterica subsp. enterica serovar Typhimurium
Esposito, G.; Vos, M.; Vilain, S.; Swerts, J.; De Sousa Valadas, J.; Van Meensel, S.; Schaap, O.; Verstreken, P.
Aconitase causes iron toxicity in Drosophila pink1 mutants
PLoS Genet.
9
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2013
Drosophila melanogaster
Kirchberg, J.; Buettner, D.; Thiemer, B.; Sawers, R.G.
Aconitase B is required for optimal growth of Xanthomonas campestris pv. vesicatoria in pepper plants
PLoS ONE
7
e34941
2012
Xanthomonas euvesicatoria
Gholampour, H.; Ghayeb Zamharir, M.; Karimi, J.; Farrokhi, N.; Alizadeh, A.; Taheri, P.
Identification of genes expressed differentially in grapefruit infected with Candidatus liberibacter asiaticus in the late stage of disease
J. Phytopathol.
162
811-819
2014
Citrus x paradisi
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Hooks, M.A.; Allwood, J.W.; Harrison, J.K.; Kopka, J.; Erban, A.; Goodacre, R.; Balk, J.
Selective induction and subcellular distribution of ACONITASE 3 reveal the importance of cytosolic citrate metabolism during lipid mobilization in Arabidopsis
Biochem. J.
463
309-317
2014
Arabidopsis thaliana (Q9SIB9), Arabidopsis thaliana
Fernandes, J.; Weddle, A.; Kinter, C.S.; Humphries, K.M.; Mather, T.; Szweda, L.I.; Kinter, M.
Lysine acetylation activates mitochondrial aconitase in the heart
Biochemistry
54
4008-4018
2015
Mus musculus (Q99KI0), Mus musculus
Reddick, J.J.; Sirkisoon, S.; Dahal, R.A.; Hardesty, G.; Hage, N.E.; Booth, W.T.; Quattlebaum, A.L.; Mills, S.N.; Meadows, V.G.; Adams, S.L.H.; Doyle, J.S.; Kiel, B.E.
First biochemical characterization of a methylcitric acid cycle from Bacillus subtilis strain 168
Biochemistry
56
5698-5711
2017
Bacillus subtilis (P09339), Bacillus subtilis 168 (P09339)
Jung, S.J.; Seo, Y.; Lee, K.C.; Lee, D.; Roe, J.H.
Essential function of Aco2, a fusion protein of aconitase and mitochondrial ribosomal protein bL21, in mitochondrial translation in fission yeast
FEBS Lett.
589
822-828
2015
Schizosaccharomyces pombe (Q9P7D4), Schizosaccharomyces pombe, Schizosaccharomyces pombe 972 (Q9P7D4)
Talib, J.; Cook, N.; Pattison, D.; Davies, M.
Disruption of the iron-sulfur cluster of aconitase by myeloperoxidase-derived oxidants
Free Radic. Biol. Med.
75 Suppl 1
S27-S28
2014
Homo sapiens
Austin, C.M.; Wang, G.; Maier, R.J.
Aconitase functions as a pleiotropic posttranscriptional regulator in Helicobacter pylori
J. Bacteriol.
197
3076-3086
2015
Helicobacter pylori (A0A2X5AHR8), Helicobacter pylori, Helicobacter pylori ATCC 43504 (A0A2X5AHR8)
Doi, Y.; Takaya, N.
A novel A3 group aconitase tolerates oxidation and nitric oxide
J. Biol. Chem.
290
1412-1421
2015
Achromobacter denitrificans (A0A090AMG4), Achromobacter denitrificans, Achromobacter denitrificans YD35 (A0A090AMG4)
Eprintsev, A.T.; Fedorin, D.N.; Nikitina, M.V.; Igamberdiev, A.U.
Expression and properties of the mitochondrial and cytosolic forms of aconitase in maize scutellum
J. Plant Physiol.
181
14-19
2015
Zea mays
Yarian, C.S.; Toroser, D.; Sohal, R.S.
Aconitase is the main functional target of aging in the citric acid cycle of kidney mitochondria from mice
Mech. Ageing Dev.
127
79-84
2006
Mus musculus
Guirola, M.; Jimenez-Marti, E.; Atrian, S.
On the molecular relationships between high-zinc tolerance and aconitase (Aco1) in Saccharomyces cerevisiae
Metallomics
6
634-645
2014
Saccharomyces cerevisiae (P19414), Saccharomyces cerevisiae
Michta, E.; Ding, W.; Zhu, S.; Blin, K.; Ruan, H.; Wang, R.; Wohlleben, W.; Mast, Y.
Proteomic approach to reveal the regulatory function of aconitase AcnA in oxidative stress response in the antibiotic producer Streptomyces viridochromogenes Tue494
PLoS ONE
9
e87905
2014
Streptomyces viridochromogenes (Q9RIL1), Streptomyces viridochromogenes, Streptomyces viridochromogenes Tue494 (Q9RIL1)
Ben-Menachem, R.; Wang, K.; Marcu, O.; Yu, Z.; Lim, T.K.; Lin, Q.; Schueler-Furman, O.; Pines, O.
Yeast aconitase mitochondrial import is modulated by interactions of its C and N terminal domains and Ssa1/2 (Hsp70)
Sci. Rep.
8
5903
2018
Saccharomyces cerevisiae (P19414), Saccharomyces cerevisiae
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