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Information on EC 4.2.1.166 - phosphinomethylmalate isomerase

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.1 Hydro-lyases
                4.2.1.166 phosphinomethylmalate isomerase
IUBMB Comments
The enzyme, characterized from the bacterium Streptomyces viridochromogenes, is involved in bialaphos biosynthesis. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase. The similar enzyme EC 4.2.1.3, aconitate hydratase, cannot catalyse this reaction.
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The expected taxonomic range for this enzyme is: Streptomyces viridochromogenes
Reaction Schemes
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Synonyms
phosphinomethylmalate isomerase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-(hydroxyphosphonoylmethyl)malate = 2-(phosphinatomethylidene)butanedioate + H2O
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(1a)
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2-(hydroxyphosphonoylmethyl)malate = 3-(hydroxyphosphonoylmethyl)malate
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overall reaction
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2-(phosphinatomethylidene)butanedioate + H2O = 3-(hydroxyphosphonoylmethyl)malate
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(1b)
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