Information on EC 4.2.1.160 - 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase

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The expected taxonomic range for this enzyme is: Chlamydia trachomatis L2/434/Bu(i)

EC NUMBER
COMMENTARY hide
4.2.1.160
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RECOMMENDED NAME
GeneOntology No.
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one = 7,8-dihydroneopterin 3'-phosphate + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)
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Folate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one cyclohydrolase
The enzyme participates in a folate biosynthesis pathway in Chlamydia.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
bifunctional enzyme, additionally catalyes the reaction of EC 5.3.1.24
UniProt
Manually annotated by BRENDA team
bifunctional enzyme, additionally catalyes the reaction of EC 5.3.1.24
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
7,8-dihydroneopterin 3'-phosphate + H2O
show the reaction diagram
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli