Information on EC 4.2.1.153 - 3-methylfumaryl-CoA hydratase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.2.1.153
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RECOMMENDED NAME
GeneOntology No.
3-methylfumaryl-CoA hydratase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-citramalyl-CoA = 3-methylfumaryl-CoA + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Carbon fixation pathways in prokaryotes
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glyoxylate assimilation
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Microbial metabolism in diverse environments
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ethylmalonyl-CoA pathway
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SYSTEMATIC NAME
IUBMB Comments
(S)-citramalyl-CoA hydro-lyase (3-methylfumaryl-CoA-forming)
The enzyme from the bacterium Chloroflexus aurantiacus is part of the 3-hydroxypropanoate cycle for carbon assimilation.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
beta-methylmalyl-CoA
mesaconyl-CoA + H2O
show the reaction diagram
mesaconyl-C4-CoA + H2O
(S)-citramalyl-CoA
show the reaction diagram
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-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
beta-methylmalyl-CoA
mesaconyl-CoA + H2O
show the reaction diagram
mesaconyl-C4-CoA + H2O
(S)-citramalyl-CoA
show the reaction diagram
A9WC41
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?
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30000
x * 30000, SDS-PAGE
37000
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x * 37000, SDS-PAGE
38000
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x * 38000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni-Sepharose column chromatography
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Ni-Sepharose column chromatography and Superdex 200 gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21 cells