Information on EC 4.2.1.151 - chorismate dehydratase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.2.1.151
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RECOMMENDED NAME
GeneOntology No.
chorismate dehydratase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
chorismate = 3-[(1-carboxyvinyl)oxy]benzoate + H2O
show the reaction diagram
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
1,4-dihydroxy-6-naphthoate biosynthesis I
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1,4-dihydroxy-6-naphthoate biosynthesis II
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Biosynthesis of secondary metabolites
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Ubiquinone and other terpenoid-quinone biosynthesis
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1,4-dihydroxy-6-naphthoate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
chorismate hydro-lyase (3-[(1-carboxyvinyl)oxy]benzoate-forming)
The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Helicobacter pylori
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-
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is part of the futalosine pathway for menaquinone biosynthesis
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
chorismate
3-[(1-carboxyvinyl)oxy]benzoate + H2O
show the reaction diagram
chorismate
aminodeoxyfutalosine + H2O
show the reaction diagram
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-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
chorismate
3-[(1-carboxyvinyl)oxy]benzoate + H2O
show the reaction diagram
chorismate
aminodeoxyfutalosine + H2O
show the reaction diagram
A0LRH5
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-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.162
chorismate
pH and temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.27
chorismate
Thermus thermophilus
Q9L0T8
pH and temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
7.8
chorismate
Thermus thermophilus
Q9L0T8
pH and temperature not specified in the publication
204
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30500
x * 30500, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 30500, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
overexpression in Escherichia coli BL21 (DE3)
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