Reference on EC 4.2.1.119 - enoyl-CoA hydratase 2
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Malila, L.H.; Siivari, K.M.; Mkel, M.J.; Jalonen, J.E.; Latip, P.M.; Kunau, W.H.; Hiltunen, J.K.
Enzymes converting D-3-hydroxyacyl-CoA to trans-2-enoyl-CoA. Microsomal and peroxisomal isoenzymes in rat liver
J. Biol. Chem.
268
21578-21585
1993
Rattus norvegicus
Fukui, T.; Shiomi, N.; Doi, Y.
Expression and characterization of (R)-specific enoyl coenzyme A hydratase involved in polyhydroxyalkanoate biosynthesis by Aeromonas caviae
J. Bacteriol.
180
667-673
1998
Aeromonas caviae
Jiang, L.L.; Kobayashi, A.; Matsuura, H.; Fukushima, H.; Hashimoto, T.
Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase
J. Biochem.
120
624-632
1996
Homo sapiens
Hisano, T.; Fukui, T.; Iwata, T.; Doi, Y.
Crystallization and preliminary X-ray analysis of (R)-specific enoyl-CoA hydratase from Aeromonas caviae involved in polyhydroxyalkanoate biosynthesis
Acta Crystallogr. Sect. D
57
145-147
2001
Aeromonas caviae
Koski, M.K.; Haapalainen, A.M.; Hiltunen, J.K.; Glumoff, T.
Crystallization and preliminary crystallographic data of 2-enoyl-CoA hydratase 2 domain of Candida tropicalis peroxisomal multifunctional enzyme type 2
Acta Crystallogr. Sect. D
59
1302-1305
2003
Candida tropicalis
Tsuge, T.; Hisano, T.; Taguchi, S.; Doi, Y.
Alteration of chain length substrate specificity of Aeromonas caviae R-enantiomer-specific enoyl-coenzyme A hydratase through site-directed mutagenesis
Appl. Environ. Microbiol.
69
4830-4836
2003
Aeromonas caviae
Park, S.J.; Lee, S.Y.
Identification and characterization of a new enoyl coenzyme A hydratase involved in biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia coli
J. Bacteriol.
185
5391-5397
2003
Escherichia coli
Qin, Y.M.; Haapalainen, A.M.; Kilpelainen, S.H.; Marttila, M.S.; Koski, M.K.; Glumoff, T.; Novikov, D.K.; Hiltunen, J.K.
Human peroxisomal multifunctional enzyme type 2: site-directed mutagenesis studies show the importance of two protic residues for 2-enoyl-CoA hydratase 2 activity
J. Biol. Chem.
275
4965-4972
2000
Homo sapiens
Kristian Koski, M.; Haapalainen, A.M.; Hiltunen, J.K.; Glumoff, T.
Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2
J. Mol. Biol.
345
1157-1169
2005
Homo sapiens (P51659), Homo sapiens
Koski, M.K.; Haapalainen, A.M.; Hiltunen, J.K.; Glumoff, T.
A two-domain structure of one subunit explains unique features of eukaryotic hydratase 2
J. Biol. Chem.
279
24666-24672
2004
Candida tropicalis (P22414), Candida tropicalis
Goepfert, S.; Hiltunen, J.K.; Poirier, Y.
Identification and functional characterization of a monofunctional peroxisomal enoyl-CoA hydratase 2 that participates in the degradation of even cis-unsaturated fatty acids in Arabidopsis thaliana
J. Biol. Chem.
281
35894-35903
2006
Arabidopsis thaliana (Q8VYI3), Arabidopsis thaliana
Hiltunen, J.K.; Filppula, S.A.; Koivuranta, K.T.; Siivari, K.; Qin, Y.M.; Haeyrinen, H.M.
Peroxisomal beta-oxidation and polyunsaturated fatty acids
Ann. N. Y. Acad. Sci.
804
116-128
1996
Rattus norvegicus
Qin, Y.; Haapalainen, A.M.; Conry, D.; Cuebas, D.A.; Hiltunen, J.K.; Novikov, D.K.
Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis
Biochem. J.
328
377-382
1997
Rattus norvegicus
-
Hiltunen, J.K.; Palosaari, P.M.; Kunau, W.H.
Epimerization of 3-hydroxyacyl-CoA esters in rat liver. Involvement of two 2-enoyl-CoA hydratases
J. Biol. Chem.
264
13536-13540
1989
Rattus norvegicus
Hiltunen, J.K.; Wenzel, B.; Beyer, A.; Erdmann, R.; Fossa, A.; Kunau, W.H.
Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product
J. Biol. Chem.
267
6646-6653
1992
Saccharomyces cerevisiae (Q02207)
Qin, Y.M.; Marttila, M.S.; Haapalainen, A.M.; Siivari, K.M.; Glumoff, T.; Hiltunen, J.K.
Yeast peroxisomal multifunctional enzyme: (3R)-hydroxyacyl-CoA dehydrogenase domains A and B are required for optimal growth on oleic acid
J. Biol. Chem.
274
28619-28625
1999
Candida tropicalis
Wu, L.; Lin, S.; Li, D.
Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation
Org. Lett.
10
3355-3358
2008
Rattus norvegicus
Qin, Y.M.; Poutanen, M.H.; Helander, H.M.; Kvist, A.P.; Siivari, K.M.; Schmitz, W.; Conzelmann, E.; Hellman, U.; Hiltunen, J.K.
Peroxisomal multifunctional enzyme of beta-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: molecular cloning, expression and characterization
Biochem. J.
321
21-28
1997
Rattus norvegicus
Engeland K, Kindl H.
Evidence for a peroxisomal fatty acid beta-oxidation involving D-3-hydroxyacyl-CoAs. Characterization of two forms of hydro-lyase that convert D-(-)-3-hydroxyacyl-CoA into 2-trans-enoyl-CoA
Eur. J. Biochem.
200
171-178
1991
Cucumis sativus
Haataja, T.J.; Koski, M.K.; Hiltunen, J.K.; Glumoff, T.
Peroxisomal multifunctional enzyme type 2 from the fruitfly: dehydrogenase and hydratase act as separate entities, as revealed by structure and kinetics
Biochem. J.
435
771-781
2011
Drosophila melanogaster
Kashiwayama, Y.; Tomohiro, T.; Narita, K.; Suzumura, M.; Glumoff, T.; Hiltunen, J.K.; Van Veldhoven, P.P.; Hatanaka, Y.; Imanaka, T.
Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative
J. Biol. Chem.
285
26315-26325
2010
Rattus norvegicus, Rattus norvegicus Wistar
Kawashima, Y.; Cheng, W.; Mifune, J.; Orita, I.; Nakamura, S.; Fukui, T.
Characterization and functional analyses of R-specific enoyl coenzyme A hydratases in polyhydroxyalkanoate-producing Ralstonia eutropha
Appl. Environ. Microbiol.
78
493-502
2012
Cupriavidus necator, Pseudomonas aeruginosa (Q9HX12), Pseudomonas aeruginosa, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
Abdel-Mawgoud, A.; Lepine, F.; Deziel, E.
A chiral high-performance liquid chromatography-tandem mass spectrometry method for the stereospecific analysis of enoyl-coenzyme A hydratases/isomerases
J. Chromatogr. A
1306
37-43
2013
Pseudomonas aeruginosa
Tsuchida, S.; Kawamoto, K.; Nunome, K.; Hamaue, N.; Hui, S.P.; Murai, T.; Aoki, T.; Kurosawa, T.
Chiral separation, determination of absolute configuration, and high-performance liquid chromatography detection of enantiomeric 3-hydroxyhexadecanoyl-CoA
J. Oleo Sci.
60
87-92
2011
Rattus norvegicus
Tsuchida, S.; Kawamoto, K.; Endo, N.; Nunome, K.; Hamaue, N.; Aoki, T.
Hydratase activities of green fluorescent protein tagged human multifunctional enzyme type 2 hydratase domain and its variants
J. Oleo Sci.
61
443-450
2012
Homo sapiens
Tsuge, T.; Sato, S.; Hiroe, A.; Ishizuka, K.; Kanazawa, H.; Shiro, Y.; Hisano, T.
Contribution of the distal pocket residue to the acyl-chain-length specificity of (R)-specific enoyl-coenzyme A hydratases from Pseudomonas spp.
Appl. Environ. Microbiol.
81
8076-8083
2015
Pseudomonas putida (A0A177YY42), Pseudomonas putida (E9P3X9), Pseudomonas putida, Pseudomonas aeruginosa (Q9LBK2), Pseudomonas aeruginosa
Kihara, T.; Hiroe, A.; Ishii-Hyakutake, M.; Mizuno, K.; Tsuge, T.
Bacillus cereus-type polyhydroxyalkanoate biosynthetic gene cluster contains R-specific enoyl-CoA hydratase gene
Biosci. Biotechnol. Biochem.
81
1627-1635
2017
Bacillus cereus (A0A150CP14), Bacillus cereus, Bacillus cereus YB-4 (A0A150CP14)
Katano, M.; Takahashi, K.; Hirano, T.; Kazama, Y.; Abe, T.; Tsukaya, H.; Ferjani, A.
Suppressor screen and phenotype analyses revealed an emerging role of the monofunctional peroxisomal enoyl-CoA hydratase 2 in compensated cell enlargement
Front. Plant Sci.
7
132
2016
Arabidopsis thaliana (Q8VYI3), Arabidopsis thaliana Col-0 (Q8VYI3)
Liu, G.; Cai, S.; Hou, J.; Zhao, D.; Han, J.; Zhou, J.; Xiang, H.
Enoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei
Sci. Rep.
6
24015
2016
Haloferax mediterranei (I3R4N1), Haloferax mediterranei, Haloferax mediterranei ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4 (I3R4N1)
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