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Information on EC 4.2.1.11 - phosphopyruvate hydratase and Organism(s) Rattus norvegicus and UniProt Accession P04764
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4.2.1.11 phosphopyruvate hydrataseIUBMB Comments
Also acts on 3-phospho-D-erythronate.
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Word Map
- 4.2.1.11
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chromogranin
- glial
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neuroendocrine
-
synaptophysin
-
fibrillary
- vimentin
-
cytokeratins
- neurofilament
- nerve
- neoplasm
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- tumour
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carcinoembryonic
- actin
- metastases
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-
resect
- desmin
- woman
-
immunocytochemical
- neuroblastoma
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cerebrospinal
- csf
- carcinoid
-
neuroectodermal
- somatostatin
-
postoperative
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primitive
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spindle
-
neurosecretory
-
pleomorphic
-
small-cell
-
polygonal
-
histogenesis
- paragangliomas
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epithelioid
-
dense-core
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merkel
-
argyrophilic
-
glasgow
- gastrin
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neuron-like
- comatose
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polypoid
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fibrovascular
- bombesin
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myxoid
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out-of-hospital
- drug development
- biofuel production
- medicine
- molecular biology
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
neuron-specific enolase, enolase, neuron specific enolase, alpha-enolase, gamma-enolase, enolase 1, beta-enolase, yeast enolase, enolase 2, eno-1, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
2-phospho-D-glycerate hydro-lyase
-
-
-
-
2-phosphoglycerate dehydratase
-
-
-
-
2-phosphoglycerate enolase
-
-
-
-
2-phosphoglyceric dehydratase
-
-
-
-
alpha,alpha-enolase
-
-
-
-
Alt a XI
-
-
-
-
beta,beta-enolase
-
-
-
-
Cla h VI
-
-
-
-
enolase
gamma,gamma-enolase
-
-
-
-
gamma-enolase
-
-
-
-
HLE1
-
-
-
-
hydratase, phosphoenolpyruvate
-
-
-
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Laminin binding protein
-
-
-
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Major allergen Alt a 11
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-
-
-
MSE
-
-
-
-
Neural enolase
-
-
-
-
neuron-specific enolase
-
-
-
-
NNE
-
-
-
-
Non-neural enolase
-
-
-
-
NSE
-
-
-
-
OSE1
-
-
-
-
phosphoenolpyruvate hydratase
-
-
-
-
Phosphopyruvate hydratase
-
-
-
-
R-NSE
-
-
-
-
Skeletal muscle enolase
-
-
-
-
Tau-crystallin
-
-
-
-
enolase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
elimination
-
-
-
-
addition
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
-
-, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
Also acts on 3-phospho-D-erythronate.
CAS REGISTRY NUMBER
COMMENTARY
9014-08-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
87
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats
SwissProt
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
enolase I (alpha,alpha-enolase), enolase II (alpha,gamma-enolase), enolase III (gamma,gamma-enolase)
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
-
in the glycolysis-related energy pathway, enolase might be involved in higher metabolic activity during the day than at night, at least in part, overview
physiological function
-
enolase plays an important role in glycolysis. It also binds RNA, overview
additional information
additional information
-
circadian rhythm of enolase in suprachiasmatic nucleus depends on mitochondrial function. Enolase activity, coupled with lactate dehydrogenase, is higher during the light period than that in the dark. However, enolase mRNA, analyzed by RT-PCR, shows higher levels during the dark period than in the light
additional information
-
proteomic analysis and peptide mapping, 2D isoelectric focusing and mass spectrometry, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ENOA_RAT
434
0
47128
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
47000
46000
49000
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of His-tagged alpha-enolase in Escherichia coli strain BL21(DE3)
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after 6 weeks of streptozotocin administration, the cardiac proteins from diabetic rats show the levels of alpha-enolase expression and protein tyrosine nitration are clearly increased, whereas the enolase activity and oxidation status are not significantly changed
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
the up-regulation of alpha-enolase expression can be a protective mechanism to neutralize oxidative and nitrative stress in diabetes
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rider, C.C.; Taylor, C.B.
Enolase isoenzymes in rat tissues. Electrophoretic, chromatographic, immunological and kinetic properties
Biochim. Biophys. Acta
365
285-300
1974
Rattus norvegicus
Sakimura, K.; Kushiya, E.; Obinata, M.; Odani, S.; Takahashi, Y.
Molecular cloning and the nucleotide sequence of cDNA for neuron-specific enolase messenger RNA of rat brain
Proc. Natl. Acad. Sci. USA
82
7453-7457
1985
Rattus norvegicus
Suzuki, F.; Umeda, Y.; Kato, K.
Rat brain enolase isozymes. Purification of three forms of enolase
J. Biochem.
87
1587-1594
1980
Rattus norvegicus
Aoki, T.; Tanaka, T.; Watabe, H.
Purification and characterization of gamma-enolase from various mammals
Chem. Pharm. Bull.
40
1236-1239
1992
Bos taurus, Canis lupus familiaris, Capra hircus, Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
Ueta, H.; Nagasawa, H.; Oyabu-Manabe, Y.; Toida, K.; Ishimura, K.; Hori, H.
Localization of enolase in synaptic plasma membrane as an alphagamma heterodimer in rat brain
Neurosci. Res.
48
379-386
2004
Rattus norvegicus
Jin, X.; Wang, L.S.; Xia, L.; Zheng, Y.; Meng, C.; Yu, Y.; Chen, G.Q.; Fang, N.Y.
Hyper-phosphorylation of alpha-enolase in hypertrophied left ventricle of spontaneously hypertensive rat
Biochem. Biophys. Res. Commun.
371
804-809
2008
Rattus norvegicus (P04764)
Lu, N.; Zhang, Y.; Li, H.; Gao, Z.
Oxidative and nitrative modifications of alpha-enolase in cardiac proteins from diabetic rats
Free Radic. Biol. Med.
48
873-881
2010
Rattus norvegicus (P04764)
Hernandez-Perez, L.; Depardon, F.; Fernandez-Ramirez, F.; Sanchez-Trujillo, A.; Bermudez-Cruz, R.M.; Dangott, L.; Montanez, C.
alpha-Enolase binds to RNA
Biochimie
93
1520-1528
2011
Rattus norvegicus
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