Reference on EC 4.2.1.1 - carbonic anhydrase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fernley, R.T.; Coghlan, J.P.; Wright, R.D.
Purification and characterization of a high-Mr carbonic anhydrase from sheep parotid gland
Biochem. J.
249
201-207
1988
Ovis aries
Murakami, H.; Sly, W.S.
Purification and characterization of human salivary carbonic anhydrase
J. Biol. Chem.
262
1382-1388
1987
Homo sapiens
Engberg, P.; Millqvist, E.; Pohl, G.; Lindskog, S.
Purification and some properties of carbonic anhydrase from bovine skeletal muscle
Arch. Biochem. Biophys.
241
628-638
1985
Bos taurus
Pullan, L.M.; Noltmann, E.A.
Purification and properties of pig muscle carbonic anhydrase III
Biochim. Biophys. Acta
839
147-154
1985
Sus scrofa
Kararli, T.; Silverman, D.N.
Inhibition of the hydration of CO2 catalyzed by carbonic anhydrase III from cat muscle
J. Biol. Chem.
260
3484-3489
1985
Felis catus
Gill, S.R.; Fedorka-Cray, P.J.; Tweten, R.K.; Sleeper, B.P.
Purification and properties of the carbonic anhydrase of Rhodospirillum
Arch. Microbiol.
138
113-118
1984
Rhodospirillum rubrum
-
Breiner Feldstein, J.; Silverman, D.N.
Purification and characterization of carbonic anhydrase from the saliva of the rat
J. Biol. Chem.
259
5447-5453
1984
Rattus norvegicus
Siffert, W.; Gros, G.
Carbonic anhydrase in human platelets
Biochem. J.
217
727-730
1984
Homo sapiens
Jones, G.L.; Shaw, D.C.
Purification, properties, partial sequence and evolutionary relationships of marsupial erythrocyte carbonic anhydrase
Biochim. Biophys. Acta
709
284-303
1982
Macropus eugenii desmarest
Henkens, R.W.; Kitchell, B.B.; Lottich, S.C.; Stein, P.J.; Williams, T.J.
Detection and characterization using circular dichroism and fluorescence spectroscopy of a stable intermediate conformation formed in the denaturation of bovine carbonic anhydrase with guanidinium chloride
Biochemistry
21
5918-5923
1982
Bos taurus
Whitney, P.L.; Briggle, T.V.
Membrane-associated carbonic anhydrase purified from bovine lung
J. Biol. Chem.
257
12056-12059
1982
Bos taurus
Nishita, T.; Deutsch, H.F.
Isolation of equine muscle carbonic anhydrase in crystalline form
Biochem. Biophys. Res. Commun.
103
573-580
1981
Equus caballus
Carter, N.; Batten, J.; Jackson, M.; Jeffery, S.; Moyle, S.
The initial stage in the dehydrogenation of dihydrodiols
Biochem. Soc. Trans.
9
73
1981
Homo sapiens, Rattus norvegicus
Bundy, H.F.; Cote, S.
Purification and properties of carbonic anhydrase from Chlamydomonas reinhardii
Phytochemistry
19
2531-2534
1980
Chlamydomonas reinhardtii
-
Sanyal, G.; Pessah, N.I.; Maren, T.H.
Kinetics and inhibition of membrane-bound carbonic anhydrase from canine renal cortex
Biochim. Biophys. Acta
657
128-137
1981
Canis lupus familiaris
Carlsson, U.; Kjellström, B.; Antonsson, B.
Purification and properties of cyclostome carbonic anhydrase from erythrocytes of hagfish
Biochim. Biophys. Acta
612
160-170
1980
Myxine glutinosa
Fernley, R.T.; Wright, R.D.; Coghlan, J.P.
A novel carbonic anhydrase from the ovine parotid gland
FEBS Lett.
105
299-302
1979
Ovis aries
Koester, M.K.; Noltmann, E.A.
Unique conformational properties of muscle carbonic anhydrase III as demonstrated by circular dichroism spectrometry
Biochemistry
18
343-348
1979
Oryctolagus cuniculus
Carter, M.J.
Carbonic anhydrase: isoenzymes, properties, distribution, and functional significance
Biol. Rev.
47
465-513
1972
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Mammalia, Petroselinum crispum, Rattus norvegicus
Pocker, Y.; Miksch, R.R.
Plant carbonic anhydrase. Properties and bicarbonate dehydration kinetics
Biochemistry
17
1119-1125
1978
Spinacia oleracea
Kandel, M.; Gornall, A.G.; Cybulsky, D.L.; Kandel, S.I.
Carbonic anhydrase from spinach leaves. Isolation and some chemical properties
J. Biol. Chem.
253
679-685
1978
Spinacia oleracea
Holmes, R.S.
Purification, molecular properties and ontogeny of carbonic anhydrase isozymes. Evidence for A, B and C isozymes in avian and mammalian tissues
Eur. J. Biochem.
78
511-520
1977
Gallus gallus, Ovis aries
Wistrand, P.J.; Wählstrand, T.
Rat renal and erythrocyte carbonic anhydrases. Purification and properties
Biochim. Biophys. Acta
481
712-721
1977
Rattus norvegicus
Drescher, D.G.
Purification of a carbonic anhydrase from the inner ear of the guinea pig
Proc. Natl. Acad. Sci. USA
74
892-896
1977
Cavia porcellus
Deutsch, H.F.; Jabusch, J.R.; Lin, K.T.D.
Purification and properties of a polymorphic high activity equine erythrocyte carbonic anhydrase
J. Biol. Chem.
252
555-559
1977
Equus caballus
Walk, R.A.; Metzner, H.
[Purification and characterization of chloroplast carbonate dehydratase from leaves of Lactuca sativa (author s transl)
Hoppe-Seyler's Z. Physiol. Chem.
356
1733-1741
1975
Lactuca sativa
Carter, N.; Auton, J.
Characterisation of carbonic anhydrases from tissues of the cat
Biochim. Biophys. Acta
410
220-228
1975
Canis lupus familiaris, Felis catus
Wistrand, P.J.; Lindahl, S.; Wählstrand, T.
Human renal carbonic anhydrase. Purification and properties
Eur. J. Biochem.
57
189-195
1975
Homo sapiens
Osborne, W.R.A.; Tashian, R.E.
An improved method for the purification of carbonic anhydrase isozymes by affinity chromatography
Anal. Biochem.
64
297-303
1975
Homo sapiens
Soliman, M.H.; Kluh, I.
Isolation of carbonic anhydrase from dog erythrocytes and determination of its N-terminal amino-acid sequence
Eur. J. Biochem.
44
611-615
1974
Canis lupus familiaris
Atkins, C.A.
Occurence and some properties of carbonic anhydrases from legume root nodules
Phytochemistry
13
93-98
1974
Bos taurus, Vicia faba, Glycine max, Medicago sativa, Lupinus sp., Melilotus sp., Phaseolus vulgaris, Pisum sativum, Trifolium repens, Vicia sativa
-
Carlsson, U.; Hannestad, U.; Lindskog, S.
Purification and some properties or erythrocyte carbonic anhydrase from the European moose
Biochim. Biophys. Acta
327
515-527
1973
Alces alces
Pocker, Y.; Ng, J.S.Y.
Plant carbonic anhydrase. Properties and carbon dioxide hydration kinetics
Biochemistry
12
5127-5134
1973
Spinacia oleracea
Bernstein, R.S.; Schraer, R.
Purification and properties of an avian carbonic anhydrase from the erythrocytes of Gallus domesticus
J. Biol. Chem.
247
1306-1322
1972
Gallus gallus
Brundell, J.; Falkbring, S.O.; Nyman, P.O.
Carbonic anhydrase from Neisseria sicca, strain 6021. II. Properties of the purified enzyme
Biochim. Biophys. Acta
284
311-323
1972
Neisseria sicca, Neisseria sicca 6021
Brundell, L.A.; Falkbring, S.O.; Nyman, P.O.
Carbonic anhydrase from Neisseria sicca, strain 6021. I. Bacterial growth and purification of the enzyme
Biochim. Biophys. Acta
284
298-310
1972
Neisseria sicca, Neisseria sicca 6021
Deutsch, H.F.
Isolation in crystalline form and properties of six horse erythrocyte carbonic anhydrases
J. Biol. Chem.
247
4499-4502
1972
Equus caballus
Lin, K.T.D.; Deutsch, H.F.
Human carbonic anhydrases. 8. Isolation and characterization of polymorphic form of a C type isozyme
J. Biol. Chem.
247
3761-3766
1972
Homo sapiens
Kisiel, W.; Graf, G.
Purification and characterization of carbonic anhydrase from Pisum sativum
Phytochemistry
11
113-117
1972
Pisum sativum
-
Tanis, R.J.; Tashian, R.E.
Purification and properties of carbonic anhydrase from sheep erythrocytes
Biochemistry
10
4852-4858
1971
Ovis aries
Yachandra, V.; Powers, L.; Spiro, T.G.
X-ray absorption spectra and the coordination number of Zn and Co carbonic anhydrase as a function of pH and inhibitor binding
J. Am. Chem. Soc.
105
6596-6604
1983
Bos taurus
-
Ren, X.; Jonsson, B.H.; Millqvist, E.; Lindskog, S.
A comparison of the kinetic properties of native bovine muscle carbonic anhydrase and an activated derivative with modified thiol groups
Biochim. Biophys. Acta
953
79-85
1988
Bos taurus
Eriksson, M.; Karlsson, J.; Ramazanov, Z.; Gardström, P.; Samuelsson, G.
Discovery of an algal mitochondrial carbonic anhydrase: molecular cloning and characterization of a low-CO2-induced polypeptide in Chlamydomonas reinhardtii
Proc. Natl. Acad. Sci. USA
93
12031-12034
1996
Chlamydomonas reinhardtii
Engstrand, C.; Jonsson, B.H.; Lindskog, S.
Catalytic and inhibitor-binding properties of some active-site mutants of human carbonic anhydrase I
Eur. J. Biochem.
229
696-702
1995
Homo sapiens
Waheed, A.; Zhu, X.L.; Sly, W.S.
Membrane-associated carbonic anhydrase from rat lung. Purification, characterization, tissue distribution, and comparison with carbonic anhydrase IVs of other mammals
J. Biol. Chem.
267
3308-3311
1992
Homo sapiens, Rattus norvegicus
Mori, K.; Ogawa, Y.; Ebihara, K.; Tamura, N.; Tashiro, K.; Kuwahara, T.; Mukoyama, M.; Sugawara, A.; Ozaki, S.; Tanaka, I.; Nakao, K.
Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney
J. Biol. Chem.
274
15701-15705
1999
Mus musculus (Q9WVT6), Mus musculus
Heck, R.W.; Tanhauser, S.M.; Manda, R.; Tu, C.; Laipis, P.J.; Silverman, D.N.
Catalytic properties of mouse carbonic anhydrase V
J. Biol. Chem.
269
24742-24746
1994
Mus musculus
Rowlett, R.S.; Gargiulo III, N.J.; Santoli, F.A.; Jackson, J.M.; Corbett, A.H.
Activation and inhibition of bovine carbonic anhydrase III by dianions
J. Biol. Chem.
266
93s-941
1961
Bos taurus
-
Chirica, L.C.; Elleby, B.; Jonsson, B.H.; Lindskog, S.
The complete sequence, expression in Escherichia coli, purification and some properties of carbonic anhydrase from Neisseria gonorrhoeae
Eur. J. Biochem.
244
755-760
1997
Neisseria gonorrhoeae
Earnhardt, J.N.; Qian, M.; Tu, C.; Lakkis, M.M.; Bergenhem, N.C.H.; Laipis, P.J.; Tashian, R.E.; Silverman, D.N.
The catalytic properties of murine carbonic anhydrase VII
Biochemistry
37
10837-10845
1998
Mus musculus
Alber, B.E.; Ferry, J.G.
Characterization of heterologously produced carbonic anhydrase from Methanosarcina thermophila
J. Bacteriol.
178
3270-3274
1996
Methanosarcina thermophila
Hurt, J.D.; Tu, C.; Laipis, P.J.; Silverman, D.N.
Catalytic properties of murine carbonic anhydrase IV
J. Biol. Chem.
272
13512-13518
1997
Mus musculus
Zhu, X.L.; Sly, W.S.
Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney
J. Biol. Chem.
265
8795-8801
1990
Homo sapiens
Hiltonen, T.; Karlsson, J.; Palmqvist, K.; Clarke, A.K.; Samuelsson, G.
Purification and characterisation of an intracellular carbonic anhydrase from the unicellular green alga Coccomyxa
Planta
195
345-351
1995
Coccomyxa sp.
Satoh, A.; Iwasaki, T.; Odani, S.; Shiraiwa, Y.
Purification, characterization and cDNA cloning of soluble carbonic anhydrase from Chlorella sorokiniana grown under ordinary air
Planta
206
657-665
1998
Chlorella sorokiniana
Rumeau, D.; Cuine, S.; Fina, L.; Gault, N.; Nicole, M.; Peltier, G.
Subcellular distribution of carbonic anhydrase in Solanum tuberosum L. leaves: characterization of two compartment-specific isoforms
Planta
199
79-88
1996
Solanum tuberosum
Mahieu, I.; Saggar-Malik, A.; Hollande, E.; Carter, N.
Localisation and characterisation of carbonic anhydrase isozymes (CA I, CA II, CA III and CA IV) in an umbilical vein endothelial cell line (EA-hy926)
Biochem. Soc. Trans.
23
308S
1995
Homo sapiens
Mahieu, I.; Carter, N.; Hollande, E
Characterization of a human ductal pancreatic Capan-1 clone (IMEH): carbonic anhydrases II and IV (CA II and CA IV) expression and targetting
Biochem. Soc. Trans.
23
309S
1995
Homo sapiens
Huang, S.; Xue, Y.; Sauer-Eriksson, E.; Chirica, L.; Lindskog, S.; Jonsson, B.H.
Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide
J. Mol. Biol.
283
301-310
1998
Neisseria gonorrhoeae (Q50940), Neisseria gonorrhoeae
Mananes, A.A.L.; Daleo, G.R.; Vega, F.V.
pH-dependent association of carbonic anhydrase (CA) with gastric light microsomal membranes isolated from bovine abomasum. Partial characterization of membrane-associated activity
Comp. Biochem. Physiol. B
105
175-182
1993
Bos taurus
Sender, S.; B¸ttcher, K.; Cetin, Y.; Gros, G.
Carbonic anhydrase in the gills of seawater- and freshwater-acclimated flounders Platichthys flesus: purification, characterization, and immunohistochemical localization
J. Histochem. Cytochem.
47
43-50
1999
Platichthys flesus
Tachiki, A.; Fukuzawa, H.; Miyachi, S.
Characterization of carbonic anhydrase isozyme CA2, which is the CAH2 gene product, in Chlamydomonas reinhardtii
Biosci. Biotechnol. Biochem.
56
794-798
1992
Chlamydomonas reinhardtii
Larsson, S.; Bjorkbacka, H.; Forsman, C.; Samuelsson, G.; Olsson, O.
Molecular cloning and biochemical characterization of carbonic anhydrase from Populus tremula x tremuloides
Plant Mol. Biol.
34
583-592
1997
Populus tremula
Lindahl, M.; Svensson, L.A.; Liljas, A.
Metal poison inhibition of carbonic anhydrase
Proteins Struct. Funct. Genet.
15
177-182
1993
Homo sapiens
Provart, N.J.; Majeau, N.; Coleman, J.R.
Characterization of pea chloroplastic carbonic anhydrase. Expression in Escherichia coli and site-directed mutagenesis
Plant Mol. Biol.
22
937-943
1993
Pisum sativum
Böttcher, K.; Waheed, A.; Sly, W.S.
Membrane-associated carbonic anhydrase from the crab gill: purification, characterization, and comparison with mammalian CAs
Arch. Biochem. Biophys.
312
429-435
1994
Carcinus maenas
Jewell, D.A.; Tu, C.; Paranawithana, S.R.; Tanhauser, S.M.; LoGrasso, P.V.; Laipis, P.J.; Silverman, D.N.
Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis
Biochemistry
30
1484-1490
1991
Homo sapiens
Wetzel, P.; Gros, G.
Inhibition and kinetic properties of membrane-bound carbonic anhydrases in rabbit skeletal muscles
Arch. Biochem. Biophys.
356
151-158
1998
Oryctolagus cuniculus
Rowlett, R.S.; Chance, M.R.; Wirt, M.D.; Sidelinger, D.E.; Royal, J.R.; Woodroffe, M.; Wang, Y.F.A.; Saha, R.P.; Lam, M.G.
Kinetic and structural characterization of spinach carbonic anhydrase
Biochemistry
33
13967-13976
1994
Spinacia oleracea
Baird, T.T.; Waheed, A.; Okuyama, T.; Sly, W.S.; Fierke, C.A.
Catalysis and inhibition of human carbonic anhydrase IV
Biochemistry
36
2669-2678
1997
Homo sapiens
Cronk, J.D.; O'Neill, J.W.; Cronk, M.R.; Endrizzi, J.A.; Zhang, K.Y.J.
Cloning, crystallization and preliminary characterization of a beta-carbonic anhydrase from Escherichia coli
Acta Crystallogr. Sect. D
56
1176-1179
2000
Escherichia coli (P61517)
-
Premkumar, L.; Greenblatt, H.M.; Bageshwar, U.K.; Savchenko, T.; Gokhman, I.; Zamir, A.; Sussman, J.L.
Identification, cDNA cloning, expression, crystallization and preliminary X-ray analysis of an exceptionally halotolerant carbonic anhydrase from Dunaliella saline
Acta Crystallogr. Sect. D
59
1084-1086
2003
Dunaliella salina
Duda, D.; Govindasamy, L.; Agbandje-Mckenna, M.; Tu, C.; Silverman, D.N.; McKenna, R.
The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer
Acta Crystallogr. Sect. D
59
93-104
2003
Homo sapiens (P00918), Homo sapiens
Saito, R.; Sato, T.; Ikai, A.; Tanaka, N.
Structure of bovine carbonic anhydrase II at 1.95 A resolution
Acta Crystallogr. Sect. D
60
792-795
2004
Bos taurus
Bjoerkbacka, H.; Johansson, I.M.; Forsman, C.
Possible roles for His 208 in the active-site region of chloroplast carbonic anhydrase from Pisum sativum
Arch. Biochem. Biophys.
361
17-24
1999
Pisum sativum
Rowlett, R.S.; Tu, C.; McKay, M.M.; Preiss, J.R.; Loomis, R.J.; Hicks, K.A.; Marchione, R.J.; Strong, J.A.; Donovan jr., G.S.; Chamberlin, J.E.
Kinetic characterization of wild-type and proton transfer-impaired variants of beta-carbonic anhydrase from Arabidopsis thaliana
Arch. Biochem. Biophys.
404
197-209
2002
Arabidopsis thaliana
Elder, I.; Han, S.; Tu, C.; Steele, H.; Laipis, P.J.; Viola, R.E.; Silverman, D.N.
Activation of carbonic anhydrase II by active-site incorporation of histidine analogs
Arch. Biochem. Biophys.
412
283-289
2004
Homo sapiens
-
Rowlett, R.S.; Tu, C.; Murray, P.S.; Chamberlin, J.E.
Examination of the role of Gln-158 in the mechanism of CO2 hydration catalyzed by beta-carbonic anhydrase from Arabidopsis thaliana
Arch. Biochem. Biophys.
425
25-32
2004
Arabidopsis thaliana
Wingo, T.; Tu, C.; Laipis, P.J.; Silverman, D.N.
The catalytic properties of human carbonic anhydrase IX
Biochem. Biophys. Res. Commun.
288
666-669
2001
Homo sapiens
Recacha, R.; Constanzo, M.J.; Maryanhoff, B.E.; Chattopadhyay, D.
Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate
Biochem. J.
361
437-441
2002
Homo sapiens (P00918), Homo sapiens
Alber, B.E.; Colangelo, C.M.; Dong, J.; Stalhandske, C.M.V.; Baird, T.T.; Tu, C.; Fierke, C.A.; Silverman, D.N.; Scott, R.A.; Ferry, J.G.
Kinetic and spectroscopic characterization of the gamma-carbonic anhydrase from the methanoarcheon Methanosarcina thermophila
Biochemistry
38
13119-13128
1999
Methanosarcina thermophila
Hunt, J.A.; Ahmed, M.; Fierke, C.A.
Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core residues
Biochemistry
38
9054-9062
1999
Homo sapiens
Cox, E.H.; McLendon, G.L.; Morel, F.M.M.; Lane, T.W.; Prince, R.C.; Pickering, I.J.; George, G.N.
The active site structure of Thalassiosira weissflogii carbonic anhydrase 1
Biochemistry
39
12128-12130
2000
Conticribra weissflogii
Guerri, A.; Briganti, F.; Scozzafava, A.; Supuran, C.T.; Mangani, S.
Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction
Biochemistry
39
12391-12397
2000
Homo sapiens (P00918), Homo sapiens
Iverson, T.M.; Alber, B.E.; Kisker, C.; Ferry, J.G.; Rees, D.C.
A closer look at the active site of gamma-class carbonic anhydrases: High resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila
Biochemistry
39
9222-9231
2000
Methanosarcina thermophila (P40881), Methanosarcina thermophila
Tripp, B.C.; Ferry, J.G.
A structure-function study of a proton transport pathway in teh gamma-class carbonic anhydrase from Methanosarcina thermophila
Biochemistry
39
9232-9240
2000
Methanosarcina thermophila
Duda, D.; Tu, C.; Qian, M.; Laipis, P.; Agbandje-McKenna, M.; Silverman, D.N.; McKenna, R.
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II
Biochemistry
40
1741-1748
2001
Homo sapiens (P00918), Homo sapiens
DiTusa, C.A.; Christensen, T.; McCall, K.A.; Fierke, C.A.; Toone, E.J.
Thermodynamics of metal ion binding. 1. Metal ion binding by wild-type carbonic anhydrase
Biochemistry
40
5338-5344
2001
Homo sapiens
DiTusa, C.A.; McCall, K.A.; Christensen, T.; Mahapatro, M.; Fierke, C.A.; Toone, E.J.
Thermodynamics of metal ion binding by carbonic anhydrase variants
Biochemistry
40
5345-5351
2001
Homo sapiens
Tu, C.; Rowlett, R.S.; Tripp, B.C.; Ferry, J.G.; Silverman, D.N.
Chemical rescue of proton transfer in catalysis by carbonic anhydrases in the beta- and gamma-class
Biochemistry
41
15429-15435
2002
Arabidopsis thaliana, Methanosarcina thermophila
Jude, K.M.; Wright, S.K.; Tu, C.; Silverman, D.N.; Viola, R.E.; Christianson, D.W.
Crystal structure of F65/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle
Biochemistry
41
2485-2491
2002
Mus musculus
An, H.; Tu, C.; Duda, D.; Montanez-Clemente, I.; Math, K.; Laipis, P.J.; McKenna, R.; Silverman, D.N.
Chemical rescue in catalysis by human carbonic anhydrases II and III
Biochemistry
41
3235-3242
2002
Homo sapiens
Ferraroni, M.; Tilli, S.; Briganti, F.; Chegwidden, W.R.; Supuran, C.T.; Wiebauer, K.E.; Tashian, R.E.; Scozzafava, A.
Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: Evidence for a second zinc binding site involving arginine coordination
Biochemistry
41
6237-6244
2002
Homo sapiens (P00915), Homo sapiens
Tripp, B.C.; Tu, C.; Ferry, J.G.
Role of the arginine 59 in the gamma-class carbonic anhydrases
Biochemistry
41
669-678
2002
Methanosarcina thermophila (P40881)
Arslan, O.
Inhibition of bovine carbonic anhydrase by new sulfonamide compounds
Biochemistry (Moscow)
66
982-983
2001
Bos taurus
Arslan, O.; Cakir, Ue.; Ugras, H.I.
Synthesis of new sulfonamide inhibitors of carbonic anhydrase
Biochemistry (Moscow)
67
1273-1276
2002
Homo sapiens
-
Qian, M.; Earnhardt, J.N.; Wadhwa, N.R.; Tu, C.; Laipis, P.J.; Silverman, D.N.
Proton transfer to residues of basic pKa during catalysis by carbonic anhydrase
Biochim. Biophys. Acta
1434
1-5
1999
Bos taurus, Homo sapiens, Mus musculus
Chirica, L.C.; Elleby, B.; Lindskog, S.
Cloning, expression and some properties of alpha-carbonic anhydrase from Helicobacter pylori
Biochim. Biophys. Acta
1544
55-63
2001
Helicobacter pylori
Sandor,M.; Riechel, A.; Kaplan, I.; Mathiowitz, E.
Effect of lecithin and MgCO3 as additives on the enzymatic activity of carbonic anhydrase encapsulated in poly(lactide-co-glycolide) (PLGA) microspheres
Biochim. Biophys. Acta
1570
63-74
2002
Bos taurus
Buelbuel, M.; Saracoglu, N.; Kuevrevioglu, Oe.I.; Ciftci, M.
Bile acid derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide as new carbonic anhydrase inhibitors: Synthesis and investigation of inhibition effects
Bioorg. Med. Chem.
10
2561-2567
2002
Homo sapiens
Scozzafava, A.; Supuran, C.T.
Hydroxyurea is a carbonic anhydrase inhibitor
Bioorg. Med. Chem.
11
2241-2246
2003
Homo sapiens
Chen, H.H.; Gross, S.; Liao, J.; MaLaughlin, M.; Dean, T.; Sly, W.S.; May, J.A.
2H-thieno[3,2-e]- and [2,3-e-]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: Synthesis, carbonic anhydrase inhibition and evaluation in the rabbit
Bioorg. Med. Chem.
8
957-975
2000
Homo sapiens
Gao, J.; Wu, Q.; Carbeck, J.; Lei, Q.P.; Smith, R.D.; Whitesides, G.M.
Probing the energetics of dissociation of carbonic anhydrase-ligand complexes in the gas phase
Biophys. J.
76
3253-3260
1999
Bos taurus, Homo sapiens
Kimber, M.S.; Pai, E.F.
The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases
EMBO J.
19
1407-1418
2000
Pisum sativum
Elleby, B.; Sjoeblom, B.; Lindskog, S.
Changing the efficiency and specificity of the esterase activity of human carbonic anhydrase II by site-specific mutagenesis
Eur. J. Biochem.
262
516-521
1999
Homo sapiens
Elleby, B.; Sjoeblom, B.; Tu, C.; Silverman, D.N.; Lindskog, S.
Enhancement of catalytic efficiency by the combination of site-specific mutations in a carbonic anhydrase-related protein
Eur. J. Biochem.
267
5908-5915
2000
Mus musculus
Elleby, B.; Chirica, L.C.; Tu, C.; Zeppezauer, M.; Lindskog, S.
Characterization of carbonic anhydrase from Neisseria gonorrhoeae
Eur. J. Biochem.
268
1613-1619
2001
Neisseria gonorrhoeae
Mallis, R.J.; Poland, B.W.; Chatterjee, T.K.; Fisher, R.A.; Darmawan, S.; Honzatko, R.B.; Thomas, J.A.
Crystal structure of S-glutathiolated carbonic anhydrase III
FEBS Lett.
482
237-241
2000
Rattus norvegicus (P14141)
Alam, M.T.; Yamada, T.; Carlsson, U.; Ikai, A.
The importance of being knotted: effects of the C-terminal knot structure on enzymatic and mechanical properties of bovine carbonic anhydrase II
FEBS Lett.
519
35-40
2002
Bos taurus
Tu, C.; Tripp, B.C.; Ferry, J.G.; Silverman, D.N.
Bicarbonate as a proton donor in catalysis by Zn(II)- and Co(II)-containing carbonic anhydrases
J. Am. Chem. Soc.
123
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2001
Homo sapiens, Methanosarcina thermophila
Loferer, M.J.; Tautermann, C.S.; Loeffler, H.H.; Liedl, K.R.
Influence of backbone conformations of human carbonic anhydrase II on carbon dioxide hydration: Hydration pathways and binding of bicarbonate
J. Am. Chem. Soc.
125
8921-8927
2003
Homo sapiens
Smith, K.S.; Ferry, J.G.
A plant-type (beta-class) carbonic anhydrase in the thermophilic methanoarchaeon Methanobacterium thermoautotrophicum
J. Bacteriol.
181
6247-6253
1999
Methanothermobacter thermautotrophicus
Smith, K.S.; Cosper, N.J.; Stalhandske, C.; Scott, R.A.; Ferry, J.G.
Structural and kinetic characterization of an archaeal beta-class carbonic anhydrase
J. Bacteriol.
182
6605-6613
2000
Spinacia oleracea (P16016), Spinacia oleracea, Methanothermobacter thermautotrophicus (Q50565), Methanothermobacter thermautotrophicus
Smith, K.S.; Ingram-Smith, C.; Ferry, J.G.
Roles of the conserved aspartate and arginine in the catalytic mechanism of an archaeal beta-class carbonic anhydrase
J. Bacteriol.
184
4240-4245
2002
Methanothermobacter thermautotrophicus
Mitsuhashi, S.; Mizushima, T.; Yamashita, E.; Yamamoto, M.; Kumasaka, T.; Moriyama, H.; Ueki, T.; Miyachi, S.; Tsukihara, T.
X-ray structure of beta-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO2 hydration
J. Biol. Chem.
275
5521-5526
2000
Porphyridium purpureum
Strop, P.; Smith, K.S.; Iverson, T.M.; Ferry, J.G.; Rees, D.C.
Crystal structure of the "cab"-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum
J. Biol. Chem.
276
10299-10305
2001
Methanothermobacter thermautotrophicus
Tu, C.; Qian, M.; An, H.; Wadhwa, N.R.; Duda, D.; Yoshioka, C.; Pathak, Y.; McKenna, R.; Laipis, P.J.; Silverman, D.N.
Kinetic analysis of multiple proton shulttles in the active site of human carbonic anhydrase
J. Biol. Chem.
277
38870-38876
2002
Homo sapiens (P00918), Homo sapiens
Lehtonen, J.; Shen, B.; Vihinen, M.; Casini, A.; Scozzafava, A.; Supuran, C.T.; Parkkila, A.K.; Saarnio, J.; Kivelae, A.J.; Waheed, A.; Sly, W.S.; Parkkila, S.
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family
J. Biol. Chem.
279
2719-2727
2004
Homo sapiens, Mus musculus (Q9D6N1), Mus musculus
Whittington, D.A.; Grubb, J.H.; Waheed, A.; Shah, G.N.; Sly, W.S.; Christianson, D.W.
Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV
J. Biol. Chem.
279
7223-7228
2004
Mus musculus
Briganti, F.; Tilli, S.; Mincione, G.; Mincione, F.; Menabuoni, L.; Supuran, C.T.
Carbonic anhydrase inhibitors. Metal complexes of 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide with topical intraocular pressure lowering properties: The influence of metal ions upon the pharmacological activity
J. Enzyme Inhib.
15
185-200
2000
Bos taurus, Homo sapiens
Fenesan, I.; Popescu, R.; Scozzafava, A.; Crucin, V.; Mateiciuc, E.; Bauer, R.; Ilies, M.A.; Supuran, C.T.
Carbonic anhydrase inhibitors; phosphoryl-sulfonamides-a new class of high affinity inhibitors of isozymes I and II
J. Enzyme Inhib.
15
297-310
2000
Homo sapiens
Scozzafava, A.; Banciu, M.D.; Popescu, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: Inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives
J. Enzyme Inhib.
15
443-453
2000
Bos taurus, Homo sapiens
Casini, A.; Minicione, F.; Ilies, M.A.; Menabuoni, L.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: Synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carbxamido moieties
J. Enzyme Inhib.
16
113-123
2001
Bos taurus
Chazalette, C.; Riviere-Baudet, M.; Scozzafava, A.; Abate, F.; Maarouf, Z.B.; Supuran, C.T.;
Carbonic anhydrase inhibitors, interaction of boron derivatives with isozymes I and II: A new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies
J. Enzyme Inhib.
16
125-133
2001
Homo sapiens
Chazalette, C.; Riviere-Baudet, M.; Supuran, C.T.; Scozzafava, A.
Carbonic anhydrase inhibitors: Allylsulfonamide, styrene sulfonamide, N-allyl sulfonamides and some of their Si, Ge and B derivatives
J. Enzyme Inhib.
16
475-489
2001
Homo sapiens
Ul-Hassan, M.; Scozzafava, A.; Chohan, Z.H.; Supuran, C.T.
Carbonic anhydrase inhibitors: Metal complexes of a sulfanilamide derived schiff base and their interaction with isozymes I, II and IV
J. Enzyme Inhib.
16
499-505
2001
Bos taurus, Homo sapiens
Buelbuel, M.; Hisar, O.; Beydemir, S.; Ciftci, M.; Kuefrevioglu, Oe.I.
The in vitro and in vivo inhibitory effects of some sulfonamide derivatives on rainbow trout (Oncorhynchus mykiss) erythrocyte carbonic anhydrase activity
J. Enzyme Inhib. Med. Chem.
18
371-375
2003
Oncorhynchus mykiss
Maffia, M.; Rizzello, A.; Acierno, R.; Rollo, M.; Chiloiro, R.; Storelli, C.
Carbonic anhydrase activity in tissues of the icefish Chionodraco hamatus and of the red-blooded teleosts Trematomus bernacchii and Anguilla anguilla
J. Exp. Biol.
204
3983-3992
2001
Anguilla anguilla, Chionodraco hamatus, Trematomus bernacchii
Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase and matrix metalloproteinase inhibitors: Sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes
J. Med. Chem.
43
3677-3687
2000
Bos taurus, Homo sapiens
Abbate, F.; Supuran, C.T.; Scozzafava, A.; Orioloi, P.; Stubbs, M.T.; Klebe, G.
Nonaromatic sulfonamide group as an ideal anchor or potent human carbonic anhydrase inhibitors: Role of hydrogen-bonding networks in ligand binding and drug design
J. Med. Chem.
45
3583-3587
2002
Homo sapiens (P00918), Homo sapiens
Winum, J.Y.; Vullo, D.; Casini, A.; Montero, J.L.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors
J. Med. Chem.
46
2197-2204
2003
Homo sapiens
Winum, J.Y.; Vullo, D.; Casini, A.; Montero, J.L.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: Inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates
J. Med. Chem.
46
5471-5477
2003
Homo sapiens
Ulmasov, B.; Waheed, A.; Shah, G.N.; Grubb, J.H.; Sly, W.S.; Tu, C.; Silverman, D.N.
Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers
Proc. Natl. Acad. Sci. USA
97
14212-14217
2000
Homo sapiens
Karhumaa, P.; Leinonen, J.; Parkkila, S.; Kaunisto, K.; Tapanainen, J.; Rajaniemi, H.
The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk
Proc. Natl. Acad. Sci. USA
98
11604-11608
2001
Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Whittington, D.A.; Waheed, A.; Ulmasov, B.; Shah, G.N.; Grubb, J.H.; Sly, W.S.; Christianson, D.W.
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells
Proc. Natl. Acad. Sci. USA
98
9545-9550
2001
Homo sapiens (O43570), Homo sapiens
Slaymaker, D.H.; Navarre, D.A.; Clark, D.; del Pozo, O.; Martin, G.B.; Klessig, D.F.
The tobacco salicylic acid-binding protein 3 (SABP3) is the chloroplast carbonic anhydrase, which exhibits antioxidant activity and plays a role in the hypersensitive defense response
Proc. Natl. Acad. Sci. USA
99
11640-11645
2002
Nicotiana tabacum (Q8W183), Nicotiana tabacum
Premkumar, L.; Bageshwar, U.K.; Gokhman, I.; Zamir, A.; Sussman, J.L.
An unusual halotolerant alpha-type carbonic anhydrase from the alga Dunaliella salina functionally expressed in Escherichia coli
Protein Expr. Purif.
28
151-157
2003
Dunaliella salina (P54212), Dunaliella salina
Cronk, J.D.; Endrizzi, J.A.; Cronk, M.R.; O'Neill, J.W.; Zhang, K.Y.J.
Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with a n unusual pH-dependent activity
Protein Sci.
10
911-922
2001
Escherichia coli (P61517), Escherichia coli
Hilvo, M.; Tolvanen, M.; Clark, A.; Shen, B.; Shah, G.N.; Waheed, A.; Halmi, P.; Hanninen, M.; Hamalainen, J.M.; Vihinen, M.; Sly, W.S.; Parkkila, S.
Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase
Biochem. J.
392
83-92
2005
Pan troglodytes, Homo sapiens (P22748), Homo sapiens, Mus musculus (Q99N23), Mus musculus
Duda, D.M.; Tu, C.; Fisher, S.Z.; An, H.; Yoshioka, C.; Govindasamy, L.; Laipis, P.J.; Agbandje-McKenna, M.; Silverman, D.N.; McKenna, R.
Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer
Biochemistry
44
10046-10053
2005
Homo sapiens (P07451), Homo sapiens
Özensoy, O.; Nishimori, I.; Vullo, D.; Puccetti, L.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition of the human transmembrane isozyme XIV with a library of aromatic/heterocyclic sulfonamides
Bioorg. Med. Chem.
13
6089-6093
2005
Homo sapiens (O43570), Homo sapiens (Q16790), Homo sapiens (Q9ULX7), Homo sapiens
Wang, B.; Liu, C.Q.; Wu, Y.
Effect of heavy metals on the activity of external carbonic anhydrase of microalga Chlamydomonas reinhardtii and microalgae from karst lakes
Bull. Environ. Contam. Toxicol.
74
227-233
2005
Chlamydomonas reinhardtii
Haritos, V.S.; Dojchinov, G.
Carbonic anhydrase metabolism is a key factor in the toxicity of CO2 and COS but not CS2 toward the flour beetle Tribolium castaneum [Coleoptera: Tenebrionidae]
Comp. Biochem. Physiol. C
140
139-147
2005
Bos taurus, Tribolium castaneum
Wroblewski, K.; Spalthoff, S.; Zimmerman, U.J.; Post, R.L.; Sanger, J.W.; Forster, R.E.
The role of carbonic anhydrase in the recovery of skeletal muscle from anoxia
J. Appl. Physiol.
99
488-498
2005
Oryctolagus cuniculus
Marcus, E.A.; Moshfegh, A.P.; Sachs, G.; Scott, D.R.
The periplasmic alpha-carbonic anhydrase activity of Helicobacter pylori is essential for acid acclimation
J. Bacteriol.
187
729-738
2005
Helicobacter pylori
Esbaugh, A.J.; Tufts, B.L.
Evidence for a membrane-bound carbonic anhydrase in the heart of an ancient vertebrate, the sea lamprey (Petromyzon marinus)
J. Comp. Physiol. B
174
399-406
2004
Petromyzon marinus
Esbaugh, A.J.; Lund, S.G.; Tufts, B.L.
Comparative physiology and molecular analysis of carbonic anhydrase from the red blood cells of teleost fish
J. Comp. Physiol. B
174
429-438
2004
Cyprinus carpio, Micropterus salmoides, Sander vitreus, Oncorhynchus mykiss (Q7T2K6), Oncorhynchus mykiss
Özensoy, Ö.; Isik, S.; Arslan, O.; Arslan, M.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of red blood cell ostrich (Struthio camelus) carbonic anhydrase with a series of aromatic and heterocyclic sulfonamides
J. Enzyme Inhib. Med. Chem.
20
383-387
2005
Struthio camelus
Demir, Y.; Nadaroglu, H.; Demir, N.
Purification and characterization of carbonic anhydrase from bovine stomach and effects of some known inhibitors on enzyme activity
J. Enzyme Inhib. Med. Chem.
20
75-80
2005
Bos taurus
Esbaugh, A.J.; Perry, S.F.; Bayaa, M.; Georgalis, T.; Nickerson, J.; Tufts, B.L.; Gilmour, K.M.
Cytoplasmic carbonic anhydrase isozymes in rainbow trout Oncorhynchus mykiss: comparative physiology and molecular evolution
J. Exp. Biol.
208
1951-1961
2005
Oncorhynchus mykiss (Q6R4A2), Oncorhynchus mykiss (Q7T2K6), Oncorhynchus mykiss
del Pilar Corena, M.; VanEkeris, L.; Salazar, M.I.; Bowers, D.; Fiedler, M.M.; Silverman, D.; Tu, C.; Linser, P.J.
Carbonic anhydrase in the adult mosquito midgut
J. Exp. Biol.
208
3263-3273
2005
Aedes aegypti, Culex quinquefasciatus, Aedes albopictus, Culex nigripalpus, Ochlerotatus taeniorhynchus, Anopheles albimanus, Anopheles quadrimaculatus
Kleinke, T.; Wagner, S.; John, H.; Hewett-Emmett, D.; Parkkila, S.; Forssmann, W.G.; Gros, G.
A distinct carbonic anhydrase in the mucus of the colon of humans and other mammals
J. Exp. Biol.
208
487-496
2005
Cavia porcellus
Innocenti, A.; Casini, A.; Alcaro, M.C.; Papini, A.M.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library
J. Med. Chem.
47
5224-5229
2004
Homo sapiens
Andrade, F.H.; Hatala, D.A.; McMullen, C.A.
Carbonic anhydrase isoform expression and functional role in rodent extraocular muscle
Pflugers Arch.
448
547-551
2004
Rattus norvegicus
Lu, Y.K.; Theg, S.M.; Stemler, A.J.
Carbonic anhydrase activity of the photosystem II OEC33 protein from pea
Plant Cell Physiol.
46
1944-1953
2005
Pisum sativum
Tanaka, Y.; Nakatsuma, D.; Harada, H.; Ishida, M.; Matsuda, Y.
Localization of soluble beta-carbonic anhydrase in the marine diatom Phaeodactylum tricornutum. Sorting to the chloroplast and cluster formation on the girdle lamellae
Plant Physiol.
138
207-217
2005
Phaeodactylum tricornutum
Shah, G.N.; Ulmasov, B.; Waheed, A.; Becker, T.; Makani, S.; Svichar, N.; Chesler, M.; Sly, W.S.
Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain
Proc. Natl. Acad. Sci. USA
102
16771-16776
2005
Mus musculus
Premkumar, L.; Greenblatt, H.M.; Bageshwar, U.K.; Savchenko, T.; Gokhman, I.; Sussman, J.L.; Zamir, A.
Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog
Proc. Natl. Acad. Sci. USA
102
7493-7498
2005
Dunaliella salina, Homo sapiens
Nagelhus, E.A.; Mathiisen, T.M.; Bateman, A.C.; Haug, F.M.; Ottersen, O.P.; Grubb, J.H.; Waheed, A.; Sly, W.S.
Carbonic anhydrase XIV is enriched in specific membrane domains of retinal pigment epithelium, Muller cells, and astrocytes
Proc. Natl. Acad. Sci. USA
102
8030-8035
2005
Mus musculus
Alber, B.E.; Ferry, J.G.
A carbonic anhydrase from the archaeon Methanosarcina thermophila
Proc. Natl. Acad. Sci. USA
91
6909-6913
1994
Methanosarcina thermophila (P40881), Methanosarcina thermophila
Bageshwar, U.K.; Premkumar, L.; Gokhman, I.; Savchenko, T.; Sussman, J.L.; Zamir, A.
Natural protein engineering: a uniquely salt-tolerant, but not halophilic, alpha-type carbonic anhydrase from algae proliferating in low- to hyper-saline environments
Protein Eng. Des. Sel.
17
191-200
2004
Dunaliella salina (P54212), Dunaliella salina
Fisher, S.Z.; Tu, C.; Bhatt, D.; Govindasamy, L.; Agbandje-McKenna, M.; McKenna, R.; Silvermann, D.N.
Speeding up proteon transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II
Biochemistry
46
3803-3813
2007
Homo sapiens (P00918), Homo sapiens
Ignatova, L.K.; Rudenko, N.N.; Khristin, M.S.; Ivanov, B.N.
Heterogeneous origin of carbonic anhydrase activity of thylakoid membranes
Biochemistry
71
525-532
2006
Pisum sativum
McConnell, I.L.; Badger, M.R.; Wydrzynski, T.; Hillier, W.
A quantitative assessment of the carbonic anhydrase activity in photosystem II
Biochim. Biophys. Acta
1767
639-647
2007
Spinacia oleracea
Fisher, S.Z.; Tariku, I.; Case, N.M.; Tu, C.; Seron, T.; Silverman, D.N.; Linser, P.J.; McKenna, R.
Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1)
Biochim. Biophys. Acta
764
1413-1419
2006
Aedes aegypti
Wu, Y.; Zhao, X.; Li, P.; Huang, H.
Impact of Zn, Cu, and Fe on the activity of carbonic anhydrase of erythrocytes in ducks
Biol. Trace Elem. Res.
118
227-232
2007
Anas platyrhynchos
Nishimori, I.; Minakuchi, T.; Onishi, S.; Vullo, D.; Cecchi, A.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides
Bioorg. Med. Chem.
15
7229-7236
2007
Homo sapiens (P07451), Homo sapiens
Temperini, C.; Winum, J.Y.; Montero, J.L.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors
Bioorg. Med. Chem. Lett.
17
2795-2801
2007
Homo sapiens (O43570), Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (Q16790), Homo sapiens
Alterio, V.; De Simone, G.; Monti, S.M.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides - solution and crystallographic studies
Bioorg. Med. Chem. Lett.
17
4201-4207
2007
Helicobacter pylori (O24855), Helicobacter pylori (Q1CVF1), Homo sapiens (O43570), Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (P07451), Homo sapiens (P22748), Homo sapiens (P23280), Homo sapiens (P35218), Homo sapiens (P43166), Homo sapiens (Q16790), Homo sapiens (Q9ULX7), Homo sapiens (Q9Y2D0), Homo sapiens, Methanosarcina thermophila (P40881), Mus musculus (Q9D6N1)
Temperini, C.; Innocenti, A.; Mastrolorenzo, A.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies
Bioorg. Med. Chem. Lett.
17
4866-4872
2007
Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (P07451), Homo sapiens (P22748), Homo sapiens (P23280), Homo sapiens (P35218), Homo sapiens (P43166), Homo sapiens (Q16790), Homo sapiens (Q9ULX7), Homo sapiens (Q9Y2D0), Mus musculus (Q9D6N1)
Guezel, O.; Temperini, C.; Innocenti, A.; Scozzafava, A.; Salman, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies
Bioorg. Med. Chem. Lett.
18
152-158
2008
Homo sapiens (O14939), Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (P07451), Homo sapiens (P22748), Homo sapiens (P23280), Homo sapiens (P35218), Homo sapiens (P43166), Homo sapiens (Q16790), Homo sapiens (Q9ULX7), Homo sapiens (Q9Y2D0), Mus musculus (Q9D6N1)
Temperini, C.; Cecchi, A.; Boyle, N.A.; Scozzafava, A.; Cabeza, J.E.; Wentworth, P.; Blackburn, G.M.; Supuran, C.T.
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: Kinetic and X-ray crystallographic studies
Bioorg. Med. Chem. Lett.
18
999-1005
2007
Homo sapiens (O43570), Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (P07451), Homo sapiens (P22748), Homo sapiens (P23280), Homo sapiens (P35218), Homo sapiens (P43166), Homo sapiens (Q16790), Homo sapiens (Q9ULX7), Homo sapiens (Q9Y2D0), Mus musculus (Q9D6N1)
Marino, S.; Hayakawa, K.; Hatada, K.; Benfatto, M.; Rizzello, A.; Maffia, M.; Bubacco, L.
Structural features that govern enzymatic activity in carbonic anhydrase from a low-temperature adapted fish, Chionodraco hamatus
Biophys. J.
93
2781-2790
2007
Homo sapiens (P00918), Homo sapiens, Chionodraco hamatus (P83299), Chionodraco hamatus
Roy, L.A.; Davis, D.A.; Saoud, I.P.; Henry, R.P.
Branchial carbonic anhydrase activity and ninhydrin positive substances in the Pacific white shrimp, Litopenaeus vannamei, acclimated to low and high salinities
Comp. Biochem. Physiol. A
147
404-411
2007
Penaeus vannamei
Hilvo, M.; Supuran, C.T.; Parkkila, S.
Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV
Curr. Top. Med. Chem.
7
893-899
2007
Homo sapiens, Homo sapiens (Q9ULX7), Mus musculus, Mus musculus (Q9D6N1), no activity in Homo sapiens
Demir, Y.; Nadaroglu, H.; Demir, N.
Purification and some properties of carbonic anhydrase from Elephas trogontherii (Steppe elephant) bone
Indian J. Biochem. Biophys.
44
252-256
2007
Elephas trogontherii
Beydemir, S.; Bulbul, M.; Hisar, O.; Soyut, H.; Yanik, T.
Carbonic anhydrase: affinity purification and kinetic properties from rainbow trout lens
Int. J. Appl. Chem.
2
45-55
2006
Oncorhynchus mykiss
-
Heinhorst, S.; Williams, E.B.; Cai, F.; Murin, C.D.; Shively, J.M.; Cannon, G.C.
Characterization of the carboxysomal carbonic anhydrase CsoSCA from Halothiobacillus neapolitanus
J. Bacteriol.
188
8087-8094
2006
Halothiobacillus neapolitanus
Hollowell, H.N.; Younvanich, S.S.; McNevin, S.L.; Britt, B.M.
Thermodynamic analysis of the low- to physiological-temperature nondenaturational conformational change of bovine carbonic anhydrase
J. Biochem. Mol. Biol.
40
205-211
2007
Bos taurus
Sawaya, M.R.; Cannon, G.C.; Heinhorst, S.; Tanaka, S.; Williams, E.B.; Yeates, T.O.; Kerfeld, C.A.
The structure of beta-carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two
J. Biol. Chem.
281
7546-7555
2006
Halothiobacillus neapolitanus
Becker, H.M.; Deitmer, J.W.
Carbonic anhydrase II increases the activity of the human electrogenic Na+/HCO3- cotransporter
J. Biol. Chem.
282
13508-13521
2007
Homo sapiens (P00918), Homo sapiens
Esbaugh, A.J.; Tufts, B.L.
Tribute to R. G. Boutilier: evidence of a high activity carbonic anhydrase isozyme in the red blood cells of an ancient vertebrate, the sea lamprey Petromyzon marinus
J. Exp. Biol.
209
1169-1178
2006
Petromyzon marinus
Serrano, L.; Halanych, K.M.; Henry, R.P.
Salinity-stimulated changes in expression and activity of two carbonic anhydrase isoforms in the blue crab Callinectes sapidus
J. Exp. Biol.
210
2320-2332
2007
Callinectes sapidus (A3FFY1), Callinectes sapidus (A3FFY2), Callinectes sapidus
Nishimori, I.; Minakuchi, T.; Onishi, S.; Vullo, D.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors
J. Med. Chem.
50
381-388
2007
Homo sapiens (P23280), Homo sapiens
Rahman, M.A.; Oomori, T.; Uehara, T.
Carbonic anhydrase in calcified endoskeleton: novel activity in biocalcification in Alcyonarian
Mar. Biotechnol.
10
31-38
2007
Lobophytum crassum
Gao, B.B.; Clermont, A.; Rook, S.; Fonda, S.J.; Srinivasan, V.J.; Wojtkowski, M.; Fujimoto, J.G.; Avery, R.L.; Arrigg, P.G.; Bursell, S.E.; Aiello, L.P.; Feener, E.P.
Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation
Nat. Med.
13
181-188
2007
Homo sapiens (P00915), Homo sapiens
Rudenko, N.N.; Ignatova, L.K.; Ivanov, B.N.
Multiple sources of carbonic anhydrase activity in pea thylakoids: soluble and membrane-bound forms
Photosynth. Res.
91
81-89
2007
Pisum sativum
Fabre, N.; Reiter, I.M.; Becuwe-Linka, N.; Genty, B.; Rumeau, D.
Characterization and expression analysis of genes encoding alpha and beta carbonic anhydrases in Arabidopsis
Plant Cell Environ.
30
617-629
2007
Arabidopsis thaliana
Tetu, S.G.; Tanz, S.K.; Vella, N.; Burnell, J.N.; Ludwig, M.
The Flaveria bidentis beta-carbonic anhydrase gene family encodes cytosolic and chloroplastic isoforms demonstrating distinct organ-specific expression patterns
Plant Physiol.
144
1316-1327
2007
Flaveria bidentis (P46510), Flaveria bidentis (Q84Y09), Flaveria bidentis (Q84Y10), Flaveria bidentis, Flaveria bidentis Kuntze (P46510), Flaveria bidentis Kuntze (Q84Y09), Flaveria bidentis Kuntze (Q84Y10)
Yu, S.; Xia, D.; Luo, Q.; Cheng, Y.; Takano, T.; Liu, S.
Purification and characterization of carbonic anhydrase of rice (Oryza sativa L.) expressed in Escherichia coli
Protein Expr. Purif.
52
379-383
2007
Oryza sativa
Rizzello, A.; Ciardiello, M.A.; Acierno, R.; Carratore, V.; Verri, T.; di Prisco, G.; Storelli, C.; Maffia, M.
Biochemical characterization of a S-glutathionylated carbonic anhydrase isolated from gills of the Antarctic icefish Chionodraco hamatus
Protein J.
26
335-348
2007
Chionodraco hamatus
Elder, I.; Fisher, Z.; Laipis, P.J.; Tu, C.; McKenna, R.; Silverman, D.N.
Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III
Proteins
68
337-343
2007
Homo sapiens (P07451), Homo sapiens
Tiwari, A.; Kumar, P.; Chawhaan, P.H.; Singh, S.; Ansari, S.A.
Carbonic anhydrase in Tectona grandis: kinetics, stability, isozyme analysis and relationship with photosynthesis
Tree Physiol.
26
1067-1073
2006
Tectona grandis
Jeyakanthan, J.; Rangarajan, S.; Mridula, P.; Kanaujia, S.P.; Shiro, Y.; Kuramitsu, S.; Yokoyama, S.; Sekar, K.
Observation of a calcium-binding site in the gamma-class carbonic anhydrase from Pyrococcus horikoshii
Acta Crystallogr. Sect. D
64
1012-1019
2008
Pyrococcus horikoshii (O59257), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O59257)
Zheng, J.; Avvaru, B.S.; Tu, C.; McKenna, R.; Silverman, D.N.
Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II
Biochemistry
47
12028-12036
2008
Homo sapiens (P00918), Homo sapiens
Genis, C.; Sippel, K.H.; Case, N.; Cao, W.; Avvaru, B.S.; Tartaglia, L.J.; Govindasamy, L.; Tu, C.; Agbandje-McKenna, M.; Silverman, D.N.; Rosser, C.J.; McKenna, R.
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties
Biochemistry
48
1322-1331
2009
Homo sapiens (P00918)
Macauley, S.R.; Zimmerman, S.A.; Apolinario, E.E.; Evilia, C.; Hou, Y.M.; Ferry, J.G.; Sowers, K.R.
The archetype gamma-class carbonic anhydrase (Cam) contains iron when synthesized in vivo
Biochemistry
48
817-819
2009
Methanosarcina thermophila
Rana, A.; Gupta, T.P.; Bansal, S.; Kundu, B.
Formation of amyloid fibrils by bovine carbonic anhydrase
Biochim. Biophys. Acta
1784
930-935
2008
Bos taurus
Soyut, H.; Beydemir, S.; Hisar, O.
Effects of some metals on carbonic anhydrase from brains of rainbow trout
Biol. Trace Elem. Res.
123
179-190
2008
Oncorhynchus mykiss
Innocenti, A.; Scozzafava, A.; Parkkila, S.; Puccetti, L.; De Simone, G.; Supuran, C.T.
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates
Bioorg. Med. Chem. Lett.
18
2267-2271
2008
Homo sapiens, Mus musculus
Innocenti, A.; Hilvo, M.; Scozzafava, A.; Parkkila, S.; Supuran, C.T.
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols
Bioorg. Med. Chem. Lett.
18
3593-3596
2008
Mus musculus
Temperini, C.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies
Bioorg. Med. Chem. Lett.
18
4282-4286
2008
Mus musculus, Homo sapiens (P00918)
Vullo, D.; Nishimori, I.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase activators: Activation of the human cytosolic isozyme III and membrane-associated isoform IV with amino acids and amines
Bioorg. Med. Chem. Lett.
18
4303-4307
2008
Homo sapiens
Innocenti, A.; Muehlschlegel, F.A.; Hall, R.A.; Steegborn, C.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions
Bioorg. Med. Chem. Lett.
18
5066-5070
2008
Candida albicans, Cryptococcus neoformans
Krungkrai, J.; Krungkrai, S.R.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition of Plasmodium falciparum carbonic anhydrase with aromatic/heterocyclic sulfonamides-in vitro and in vivo studies
Bioorg. Med. Chem. Lett.
18
5466-5471
2008
Plasmodium falciparum
Innocenti, A.; Zimmerman, S.A.; Scozzafava, A.; Ferry, J.G.; Supuran, C.T.
Carbonic anhydrase activators: activation of the archaeal beta-class (Cab) and gamma-class (Cam) carbonic anhydrases with amino acids and amines
Bioorg. Med. Chem. Lett.
18
6194-6198
2008
Methanothermobacter thermautotrophicus, Methanosarcina thermophila
Isik, S.; Kockar, F.; Arslan, O.; Guler, O.O.; Innocenti, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions
Bioorg. Med. Chem. Lett.
18
6327-6331
2008
Saccharomyces cerevisiae
Bertucci, A.; Innocenti, A.; Zoccola, D.; Scozzafava, A.; Allemand, D.; Tambutte, S.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions
Bioorg. Med. Chem. Lett.
19
650-653
2009
Stylophora pistillata
Bayram, E.; Senturk, M.; Kufrevioglu, O.I.; Supuran, C.T.
In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II
Bioorg. Med. Chem.
16
9101-9105
2008
Homo sapiens
Isik, S.; Kockar, F.; Aydin, M.; Arslan, O.; Guler, O.O.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates
Bioorg. Med. Chem.
17
1158-1163
2009
Saccharomyces cerevisiae
Bootorabi, F.; Jaenis, J.; Valjakka, J.; Isoniemi, S.; Vainiotalo, P.; Vullo, D.; Supuran, C.T.; Waheed, A.; Sly, W.S.; Niemelae, O.; Parkkila, S.
Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity
BMC Biochem.
9
32
2008
Homo sapiens
Lazova, G.N.; Stemler, A.J.
A 160 kDa protein with carbonic anhydrase activity is complexed with rubisco on the outer surface of thylakoids
Cell Biol. Int.
32
646-653
2008
Pisum sativum
Marie, B.; Luquet, G.; Bedouet, L.; Milet, C.; Guichard, N.; Medakovic, D.; Marin, F.
Nacre calcification in the freshwater mussel Unio pictorum: carbonic anhydrase activity and purification of a 95 kDa calcium-binding glycoprotein
ChemBioChem
9
2515-2523
2008
Unio pictorum
Pongsomboon, S.; Udomlertpreecha, S.; Amparyup, P.; Wuthisuthimethavee, S.; Tassanakajon, A.
Gene expression and activity of carbonic anhydrase in salinity stressed Penaeus monodon
Comp. Biochem. Physiol. A
152
225-233
2009
Penaeus monodon
Hilvo, M.; Innocenti, A.; Monti, S.M.; De Simone, G.; Supuran, C.T.; Parkkila, S.
Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV
Curr. Pharm. Des.
14
672-678
2008
Homo sapiens, Mus musculus
Ye, C.; Gao, K.; Giordano, M.
The odd behaviour of carbonic anhydrase in the terrestrial cyanobacterium Nostoc flagelliforme during hydration-dehydration cycles
Environ. Microbiol.
10
1018-1023
2008
Nostoc flagelliforme
Choi, S.W.; Kim, J.Y.; Park, J.Y.; Cha, I.H.; Kim, J.; Lee, S.
Expression of carbonic anhydrase IX is associated with postoperative recurrence and poor prognosis in surgically treated oral squamous cell carcinoma
Hum. Pathol.
39
1317-1322
2008
Homo sapiens
Sun, X.C.; Li, J.; Cui, M.; Bonanno, J.A.
Role of carbonic anhydrase IV in corneal endothelial HCO3- transport
Invest. Ophthalmol. Vis. Sci.
49
1048-1055
2008
Bos taurus
Maupin, C.M.; Saunders, M.G.; Thorpe, I.F.; McKenna, R.; Silverman, D.N.; Voth, G.A.
Origins of enhanced proton transport in the Y7F mutant of human carbonic anhydrase II
J. Am. Chem. Soc.
130
11399-11408
2008
Homo sapiens (P00918), Homo sapiens
Gokhale, N.H.; Bradford, S.; Cowan, J.A.
Catalytic inactivation of human carbonic anhydrase I by a metallopeptide-sulfonamide conjugate is mediated by oxidation of active site residues
J. Am. Chem. Soc.
130
2388-2389
2008
Homo sapiens (P00915), Homo sapiens
Swingley, W.D.; Sadekar, S.; Mastrian, S.D.; Matthies, H.J.; Hao J.; Ramos, H.; Acharya, C.R.; Conrad, A.L.; Taylor, H.L.; Dejesa, L.C.; Shah, M.K.; O'huallachain, M.E.; Lince, M.T.; Blankenship, R.E.; Beatty, J.T.; Touchman, J.W.
The complete genome sequence of Roseobacter denitrificans reveals a mixotrophic rather than photosynthetic metabolism
J. Bacteriol.
189
683-690
2007
Roseobacter denitrificans OCh 114
Moya, A.; Tambutte, S.; Bertucci, A.; Tambutte, E.; Lotto, S.; Vullo, D.; Supuran, C.T.; Allemand, D.; Zoccola, D.
Carbonic anhydrase in the scleractinian coral Stylophora pistillata: characterization, localization, and role in biomineralization
J. Biol. Chem.
283
25475-25484
2008
Stylophora pistillata (B5SU02), Stylophora pistillata
Hilvo, M.; Baranauskiene, L.; Salzano, A.M.; Scaloni, A.; Matulis, D.; Innocenti, A.; Scozzafava, A.; Monti, S.M.; Di Fiore, A.; De Simone, G.; Lindfors, M.; Jaenis, J.; Valjakka, J.; Pastorekova, S.; Pastorek, J.; Kulomaa, M.S.; Nordlund, H.R.; Supuran, C.T.; Parkkila, S.
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
J. Biol. Chem.
283
27799-27809
2008
Homo sapiens (Q16790)
Domsic, J.F.; Avvaru, B.S.; Kim, C.U.; Gruner, S.M.; Agbandje-McKenna, M.; Silverman, D.N.; McKenna, R.
Entrapment of carbon dioxide in the active site of carbonic anhydrase II
J. Biol. Chem.
283
30766-30771
2008
Homo sapiens (P00918), Homo sapiens
Coban, T.A.; Beydemir, S.; Guelcin, I.; Ekinci, D.
The effect of ethanol on erythrocyte carbonic anhydrase isoenzymes activity: an in vitro and in vivo study
J. Enzyme Inhib. Med. Chem.
23
266-270
2008
Homo sapiens, Rattus norvegicus
Buelbuel, M.; Kasimogullari, R.; Kuefrevioglu, O.I.
Amide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibitory effects
J. Enzyme Inhib. Med. Chem.
23
895-900
2008
Homo sapiens
Nishimori, I.; Minakuchi, T.; Onishi, S.; Vullo, D.; Cecchi, A.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Cloning, characterization and inhibition studies of the cytosolic isozyme III with anions
J. Enzyme Inhib. Med. Chem.
24
70-76
2009
Homo sapiens (P07451), Homo sapiens
Wilkinson, B.L.; Innocenti, A.; Vullo, D.; Supuran, C.T.; Poulsen, S.A.
Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides
J. Med. Chem.
51
1945-1953
2008
Homo sapiens
Temperini, C.; Cecchi, A.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference
J. Med. Chem.
52
322-328
2009
Homo sapiens (P00918)
Hilvo, M.; Salzano, A.M.; Innocenti, A.; Kulomaa, M.S.; Scozzafava, A.; Scaloni, A.; Parkkila, S.; Supuran, C.T.
Cloning, expression, post-Translational modifications and inhibition Studies on the latest mammalian carbonic anhydrase isoform, CA XV
J. Med. Chem.
52
646-654
2009
Mus musculus (Q99N23), Mus musculus
Schlicker, C.; Hall, R.A.; Vullo, D.; Middelhaufe, S.; Gertz, M.; Supuran, C.T.; Muehlschlegel, F.A.; Steegborn, C.
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans
J. Mol. Biol.
385
1207-1220
2009
Cryptococcus neoformans
Gailly, P.; Jouret, F.; Martin, D.; Debaix, H.; Parreira, K.S.; Nishita, T.; Blanchard, A.; Antignac, C.; Willnow, T.E.; Courtoy, P.J.; Scheinman, S.J.; Christensen, E.I.; Devuyst, O.
A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunction
Kidney Int.
74
52-61
2008
Mus musculus (P16015)
Malentacchi, F.; Simi, L.; Nannelli, C.; Andreani, M.; Janni, A.; Pastorekova, S.; Orlando, C.
Alternative splicing variants of carbonic anhydrase IX in human non-small cell lung cancer
Lung Cancer
64
271-276
2009
Homo sapiens
Dai, H.Y.; Hong, C.C.; Liang, S.C.; Yan, M.D.; Lai, G.M.; Cheng, A.L.; Chuang, S.E.
Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathway
Mol. Carcinog.
47
956-963
2008
Homo sapiens
Xu, Y.; Feng, L.; Jeffrey, P.D.; Shi, Y.; Morel, F.M.
Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms
Nature
452
56-61
2008
Conticribra weissflogii
Haapasalo, J.; Hilvo, M.; Nordfors, K.; Haapasalo, H.; Parkkila, S.; Hyrskyluoto, A.; Rantala, I.; Waheed, A.; Sly, W.S.; Pastorekova, S.; Pastorek, J.; Parkkila, A.K.
Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas
Neuro-oncology
10
131-138
2008
Homo sapiens
Frison, G.; Ohanessian, G.
Metal-histidine-glutamate as a regulator of enzymatic cycles: a case study of carbonic anhydrase
Phys. Chem. Chem. Phys.
11
374-383
2009
Homo sapiens (P00918), Homo sapiens
Martin, C.L.; Tortell, P.D.
Bicarbonate transport and extracellular carbonic anhydrase in marine diatoms
Physiol. Plant.
133
106-116
2008
Cylindrotheca fusiformis, Phaeodactylum tricornutum, Skeletonema costatum, Thalassiosira oceanica, Thalassiosira pseudonana, Conticribra weissflogii, Asterionella glacialis, Chaetoceros decipiens, Chaetoceros socialis, Chaetoceros vixvisibilis, Grammatophora oceanica, Leptocylindrus minimus, Leyanella arenaria, Nitzschia thermalis, Odontella aurita, Pseudo-nitzschia granii, Pseudo-nitzschia turgidula
Ynalvez, R.A.; Xiao, Y.; Ward, A.S.; Cunnusamy, K.; Moroney, J.V.
Identification and characterization of two closely related beta-carbonic anhydrases from Chlamydomonas reinhardtii
Physiol. Plant.
133
15-26
2008
Chlamydomonas reinhardtii, Chlamydomonas reinhardtii D66
Kitao, Y.; Harada, H.; Matsuda, Y.
Localization and targeting mechanisms of two chloroplastic beta-carbonic anhydrases in the marine diatom Phaeodactylum tricornutum
Physiol. Plant.
133
68-77
2008
Phaeodactylum tricornutum (Q5W8G5), Phaeodactylum tricornutum, Phaeodactylum tricornutum UTEX642 (Q5W8G5)
McGinn, P.J.; Morel, F.M.
Expression and regulation of carbonic anhydrases in the marine diatom Thalassiosira pseudonana and in natural phytoplankton assemblages from Great Bay, New Jersey
Physiol. Plant.
133
78-91
2008
Thalassiosira pseudonana
Lapointe, M.; Mackenzie, T.D.; Morse, D.
An external delta-carbonic anhydrase in a free-living marine dinoflagellate may circumvent diffusion-limited carbon acquisition
Plant Physiol.
147
1427-1436
2008
Lingulodinium polyedra
Ferreira, F.J.; Guo, C.; Coleman, J.R.
Reduction of plastid-localized carbonic anhydrase activity results in reduced Arabidopsis seedling survivorship
Plant Physiol.
147
585-594
2008
Arabidopsis thaliana
Duanmu, D.; Wang, Y.; Spalding, M.H.
Thylakoid lumen carbonic anhydrase (CAH3) mutation suppresses air-dier phenotype of LCIB mutant in Chlamydomonas reinhardtii
Plant Physiol.
149
929-937
2008
Chlamydomonas reinhardtii
Inada, A.; Nienaber, C.; Katsuta, H.; Fujitani, Y.; Levine, J.; Morita, R.; Sharma, A.; Bonner-Weir, S.
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
Proc. Natl. Acad. Sci. USA
105
19915-19919
2008
Homo sapiens
Soyut, H.; Beydemir, S.
Purification and some kinetic properties of carbonic anhydrase from rainbow trout (Oncorhynchus mykiss) liver and metal inhibition
Protein Pept. Lett.
15
528-535
2008
Oncorhynchus mykiss
Di Fiore, A.; Monti, S.M.; Hilvo, M.; Parkkila, S.; Romano, V.; Scaloni, A.; Pedone, C.; Scozzafava, A.; Supuran, C.T.; De Simone, G.
Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide
Proteins
74
164-175
2009
Homo sapiens
Tasgin, E.; Nadaroglu, H.; Demir, Y.; Demir, N.
Purification and properties of carbonic anhydrase from bone marrow
Asian J. Chem.
21
5117-5122
2009
Bos taurus
-
Maupin, C.M.; Zheng, J.; Tu, C.; McKenna, R.; Silverman, D.N.; Voth, G.A.
Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II
Biochemistry
48
7996-8005
2009
Homo sapiens (P00918), Homo sapiens
Avvaru, B.S.; Kim, C.U.; Sippel, K.H.; Gruner, S.M.; Agbandje-McKenna, M.; Silverman, D.N.; McKenna, R.
A short, strong hydrogen bond in the active site of human carbonic anhydrase II
Biochemistry
49
249-251
2010
Homo sapiens (P00918), Homo sapiens
De Simone, G.; Supuran, C.T.
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
Biochim. Biophys. Acta
1804
404-409
2010
Homo sapiens
Sugimoto, A.; Ikeda, H.; Tsukamoto, H.; Kihira, K.; Ishioka, M.; Hirose, J.; Hata, T.; Fujioka, H.; Ono, Y.
Timolol activates the enzyme activities of human carbonic anhydrase I and II
Biol. Pharm. Bull.
33
301-306
2010
Homo sapiens
Innocenti, A.; Hilvo, M.; Parkkila, S.; Scozzafava, A.; Supuran, C.
Carbonic anhydrase inhibitors: The membrane-associated isoform XV is highly inhibited by inorganic anions
Bioorg. Med. Chem. Lett.
19
1155-1158
2009
Mus musculus
Abdo, M.R.; Vullo, D.; Saada, M.C.; Montero, J.L.; Scozzafava, A.; Winum, J.Y.; Supuran, C.T.
Carbonic anhydrase activators: activation of human isozymes I, II and IX with phenylsulfonylhydrazido L-histidine derivatives
Bioorg. Med. Chem. Lett.
19
2440-2443
2009
Homo sapiens (P00918), Homo sapiens
Guezel, O.; Innocenti, A.; Scozzafava, A.; Salman, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors
Bioorg. Med. Chem. Lett.
19
3170-3173
2009
Homo sapiens
Innocenti, A.; Leewattanapasuk, W.; Manole, G.; Scozzafava, A.; Muehlschlegel, F.A.; Supuran, C.T.
Carbonic anhydrase activators: Activation of the beta-carbonic anhydrase from the pathogenic yeast Candida glabrata with amines and amino acids
Bioorg. Med. Chem. Lett.
20
1701-1704
2010
[Candida] glabrata
Vullo, D.; Nishimori, I.; Scozzafava, A.; Koehler, S.; Winum, J.Y.; Supuran, C.T.
Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides
Bioorg. Med. Chem. Lett.
20
2178-2182
2010
Brucella suis (A0A0H3GB68), Brucella suis
Guezel, O.; Innocenti, A.; Scozzafava, A.; Salman, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB
Bioorg. Med. Chem.
17
4894-4899
2009
Homo sapiens, Homo sapiens (P35218), Homo sapiens (Q9Y2D0)
Bertucci, A.; Innocenti, A.; Zoccola, D.; Scozzafava, A.; Tambutte, S.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides
Bioorg. Med. Chem.
17
5054-5058
2009
Stylophora pistillata
Innocenti, A.; Hall, R.A.; Scozzafava, A.; Muehlschlegel, F.A.; Supuran, C.T.
Carbonic anhydrase activators: activation of the beta-carbonic anhydrases from the pathogenic fungi Candida albicans and Cryptococcus neoformans with amines and amino acids
Bioorg. Med. Chem.
18
1034-1037
2010
Candida albicans, Cryptococcus neoformans
Davis, R.A.; Innocenti, A.; Poulsen, S.A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library
Bioorg. Med. Chem.
18
14-18
2010
Homo sapiens
Bertucci, A.; Zoccola, D.; Tambutte, S.; Vullo, D.; Supuran, C.T.
Carbonic anhydrase activators. The first activation study of a coral secretory isoform with amino acids and amines
Bioorg. Med. Chem.
18
2300-2303
2010
Stylophora pistillata
Innocenti, A.; Durdagi, S.; Doostdar, N.; Strom, T.A.; Barron, A.R.; Supuran, C.T.
Nanoscale enzyme inhibitors: fullerenes inhibit carbonic anhydrase by occluding the active site entrance
Bioorg. Med. Chem.
18
2822-2828
2010
Homo sapiens
Ramanan, R.; Kannan, K.; Vinayagamoorthy, N.; Ramkumar, K.; Sivanesan, S.; Chakrabarti, T.
Purification and characterization of a novel plant-type carbonic anhydrase from Bacillus subtilis
Biotechnol. Bioprocess Eng.
14
32-37
2009
Bacillus subtilis, Bacillus subtilis SA3
-
Liu, Z.; Bartlow, P.; Dilmore, R.M.; Soong, Y.; Pan, Z.; Koepsel, R.; Ataai, M.
Production, purification, and characterization of a fusion protein of carbonic anhydrase from Neisseria gonorrhoeae and cellulose binding domain from Clostridium thermocellum
Biotechnol. Prog.
25
68-74
2009
Neisseria gonorrhoeae
Teng, Y.B.; Jiang, Y.L.; He, Y.X.; He, W.W.; Lian, F.M.; Chen, Y.; Zhou, C.Z.
Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103
BMC Struct. Biol.
9
67
2009
Saccharomyces cerevisiae (P53615), Saccharomyces cerevisiae
Li, Y.; Wang, H.; Oosterwijk, E.; Tu, C.; Shiverick, K.T.; Silverman, D.N.; Frost, S.C.
Expression and activity of carbonic anhydrase IX is associated with metabolic dysfunction in MDA-MB-231 breast cancer cells
Cancer Invest.
27
613-623
2009
Homo sapiens
Carta, F.; Pothen, B.; Maresca, A.; Tiwari, M.; Singh, V.; Supuran, C.T.
Carbonic anhydrase inhibitors: inhibition of cytosolic carbonic anhydrase isozymes II and VII with simple aromatic sulfonamides and some azo dyes
Chem. Biol. Drug Des.
74
196-202
2009
Homo sapiens
Roberto, C.; Giulia, L.M.; Francesco, D.; Aldo, V.; Trifone, S.
Carbonic anhydrase activity in Mytilus galloprovincialis digestive gland: Sensitivity to heavy metal exposure
Comp. Biochem. Physiol. C
152
241-247
2010
Mytilus galloprovincialis
Benfodda, Z.; Guillen, F.; Romestand, B.; Dahmani, A.; Blancou, H.
Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase
Eur. J. Med. Chem.
45
1225-1229
2010
Bos taurus, Homo sapiens
Brzozowski, Z.; Slawinski, J.; Saczewski, F.; Innocenti, A.; Supuran, C.T.
Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides
Eur. J. Med. Chem.
45
2396-2404
2010
Homo sapiens
Kaur, S.; Mishra, M.N.; Tripathi, A.K.
Regulation of expression and biochemical characterization of a beta-class carbonic anhydrase from the plant growth-promoting rhizobacterium, Azospirillum brasilense Sp7
FEMS Microbiol. Lett.
299
149-158
2009
Azospirillum brasilense, Azospirillum brasilense Sp7
Kalloniati, C.; Tsikou, D.; Lampiri, V.; Fotelli, M.N.; Rennenberg, H.; Chatzipavlidis, I.; Fasseas, C.; Katinakis, P.; Flemetakis, E.
Characterization of a Mesorhizobium loti alpha-type carbonic anhydrase and its role in symbiotic nitrogen fixation
J. Bacteriol.
191
2593-2600
2009
Mesorhizobium loti (Q8KJM6), Mesorhizobium loti, Mesorhizobium loti R7A (Q8KJM6)
Baranauskiene, L.; Hilvo, M.; Matuliene, J.; Golovenko, D.; Manakova, E.; Dudutiene, V.; Michailoviene, V.; Torresan, J.; Jachno, J.; Parkkila, S.; Maresca, A.; Supuran, C.T.; Grazulis, S.; Matulis, D.
Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides
J. Enzyme Inhib. Med. Chem.
25
863-870
2010
Homo sapiens (Q16790), Homo sapiens
Minakuchi, T.; Nishimori, I.; Vullo, D.; Scozzafava, A.; Supuran, C.T.
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate
J. Med. Chem.
52
2226-2232
2009
Mycobacterium tuberculosis
Nishimori, I.; Minakuchi, T.; Vullo, D.; Scozzafava, A.; Innocenti, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis
J. Med. Chem.
52
3116-3120
2009
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Joseph, P.; Turtaut, F.; Ouahrani-Bettache, S.; Montero, J.L.; Nishimori, I.; Minakuchi, T.; Vullo, D.; Scozzafava, A.; Koehler, S.; Winum, J.Y.; Supuran, C.T.
Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis
J. Med. Chem.
53
2277-2285
2010
Brucella suis (A0A0H3GB68), Brucella suis
Gitto, R.; Agnello, S.; Ferro, S.; De Luca, L.; Vullo, D.; Brynda, J.; Mader, P.; Supuran, C.T.; Chimirri, A.
Identification of 3,4-dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies
J. Med. Chem.
53
2401-2408
2010
Homo sapiens, Homo sapiens (P00918)
Maresca, A.; Temperini, C.; Pochet, L.; Masereel, B.; Scozzafava, A.; Supuran, C.T.
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins
J. Med. Chem.
53
335-344
2010
Homo sapiens (P00918)
Alterio, V.; Hilvo, M.; Di Fiore, A.; Supuran, C.T.; Pan, P.; Parkkila, S.; Scaloni, A.; Pastorek, J.; Pastorekova, S.; Pedone, C.; Scozzafava, A.; Monti, S.M.; De Simone, G.
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
Proc. Natl. Acad. Sci. USA
106
16233-16238
2009
Homo sapiens (Q16790), Homo sapiens
Pena, K.L.; Castel, S.E.; de Araujo, C.; Espie, G.S.; Kimber, M.S.
Structural basis of the oxidative activation of the carboxysomal gamma-carbonic anhydrase, CcmM
Proc. Natl. Acad. Sci. USA
107
2455-2460
2010
Thermosynechococcus vestitus
Sharma, A.; Bhattacharya, A.; Singh, S.
Purification and characterization of an extracellular carbonic anhydrase from Pseudomonas fragi
Process Biochem.
44
1293-1297
2009
Pseudomonas fragi
-
Picaud, S.; Muniz, J.; Kramm, A.; Pilka, E.; Kochan, G.; Oppermann, U.; Yue, W.
Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing
Proteins
76
507-511
2009
Homo sapiens (P35219), Homo sapiens
Suzuki, K.; Shimizu, S.; Juan, E.C.; Miyamoto, T.; Fang, Z.; Hoque, M.M.; Sato, Y.; Tsunoda, M.; Sekiguchi, T.; Takenaka, A.; Yang, S.Y.
Crystallographic study of wild-type carbonic anhydrase alpha CA1 from Chlamydomonas reinhardtii
Acta Crystallogr. Sect. F
66
1082-1085
2010
Chlamydomonas reinhardtii
Nishita, T.; Tomita, Y.; Imanari, T.; Ichihara, N.; Orito, K.; Arishima, K.
Biochemical and developmental characterization of carbonic anhydrase II from chicken erythrocytes
Acta Vet. Scand.
53
16
2011
Gallus gallus, Gallus gallus Araucana-chicken
Avvaru, B.S.; Arenas, D.J.; Tu, C.; Tanner, D.B.; McKenna, R.; Silverman, D.N.
Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II
Arch. Biochem. Biophys.
502
53-59
2010
Homo sapiens (P00918), Homo sapiens
Mikulski, R.; Avvaru, B.S.; Tu, C.; Case, N.; McKenna, R.; Silverman, D.N.
Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II
Arch. Biochem. Biophys.
506
181-187
2011
Homo sapiens
Hoffmann, K.M.; Samardzic, D.; Heever, K.; Rowlett, R.S.
Co(II)-substituted Haemophilus influenzae beta-carbonic anhydrase: spectral evidence for allosteric regulation by pH and bicarbonate ion
Arch. Biochem. Biophys.
511
80-87
2011
Haemophilus influenzae
Rowlett, R.S.; Hoffmann, K.M.; Failing, H.; Mysliwiec, M.M.; Samardzic, D.
Evidence for a bicarbonate escort site in Haemophilus influenzae beta-carbonic anhydrase
Biochemistry
49
3640-3647
2010
Haemophilus influenzae (P45148), Haemophilus influenzae
Domsic, J.F.; Williams, W.; Fisher, S.Z.; Tu, C.; Agbandje-McKenna, M.; Silverman, D.N.; McKenna, R.
Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II
Biochemistry
49
6394-6399
2010
Homo sapiens
Li, Y.; Wang, H.; Tu, C.; Shiverick, K.T.; Silverman, D.N.; Frost, S.C.
Role of hypoxia and EGF on expression, activity, localization and phosphorylation of carbonic anhydrase IX in MDA-MB-231 breast cancer cells
Biochim. Biophys. Acta
1813
159-167
2011
Homo sapiens
Tsikou, D.; Stedel, C.; Kouri, E.D.; Udvardi, M.K.; Wang, T.L.; Katinakis, P.; Labrou, N.E.; Flemetakis, E.
Characterization of two novel nodule-enhanced alpha-type carbonic anhydrases from Lotus japonicus
Biochim. Biophys. Acta
1814
496-504
2011
Lotus japonicus (A7DX12), Lotus japonicus (A7DX13), Lotus japonicus, Lotus japonicus Gifu B-129 (A7DX12), Lotus japonicus Gifu B-129 (A7DX13)
Maresca, A.; Scozzafava, A.; Supuran, C.T.
7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range
Bioorg. Med. Chem. Lett.
20
7255-7258
2010
Homo sapiens
Rodriguez, O.M.; Maresca, A.; Tempera, C.A.; Bravo, R.D.; Colinas, P.A.; Supuran, C.T.
N-beta-Glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII
Bioorg. Med. Chem. Lett.
21
4447-4450
2011
Homo sapiens
Saada, M.C.; Vullo, D.; Montero, J.L.; Scozzafava, A.; Winum, J.Y.; Supuran, C.T.
Carbonic anhydrase I and II activation with mono- and dihalogenated histamine derivatives
Bioorg. Med. Chem. Lett.
21
4884-4887
2011
Homo sapiens
Knaus, E.E.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II
Bioorg. Med. Chem. Lett.
21
5892-5896
2011
Homo sapiens
Bertucci, A.; Innocenti, A.; Scozzafava, A.; Tambutte, S.; Zoccola, D.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata
Bioorg. Med. Chem. Lett.
21
710-714
2011
Stylophora pistillata
Joseph, P.; Ouahrani-Bettache, S.; Montero, J.L.; Nishimori, I.; Minakuchi, T.; Vullo, D.; Scozzafava, A.; Winum, J.Y.; Koehler, S.; Supuran, C.T.
A new beta-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth
Bioorg. Med. Chem.
19
1172-1178
2011
Brucella suis (A0A0H3GB68), Brucella suis, Brucella suis 1330 (A0A0H3GB68)
Durdagi, S.; Sentuerk, M.; Ekinci, D.; Balaydin, H.T.; Goeksu, S.; Kuefrevioglu, Ö.I.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site
Bioorg. Med. Chem.
19
1381-1389
2011
Homo sapiens
Cincinelli, A.; Martellini, T.; Innocenti, A.; Scozzafava, A.; Supuran, C.T.
Purification and inhibition studies with anions and sulfonamides of an alpha-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii
Bioorg. Med. Chem.
19
1847-1851
2011
Leptonychotes weddellii
Xiao, Z.; Duan, R.; Cui, W.; Zhang, Y.; Zhang, S.; Chen, F.; Zhang, Y.; Liu, J.; Zhang, D.; Meng, Y.; Wang, L.; Wang, H.
Synthesis and evaluation of new carbonic anhydrase inhibitors
Bioorg. Med. Chem.
19
3221-3228
2011
Homo sapiens
Biswas, S.; Aggarwal, M.; Guezel, O.e.; Scozzafava, A.; McKenna, R.; Supuran, C.T.
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms
Bioorg. Med. Chem.
19
3732-3738
2011
Homo sapiens
Syrjaenen, L.; Tolvanen, M.; Hilvo, M.; Olatubosun, A.; Innocenti, A.; Scozzafava, A.; Leppiniemi, J.; Niederhauser, B.; Hytoenen, V.P.; Gorr, T.A.; Parkkila, S.; Supuran, C.T.
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates
BMC Biochem.
11
28
2010
Drosophila melanogaster
Sentuerk, M.; Guelcin, I.; Beydemir, S.; Kuefrevioglu, O.I.; Supuran, C.T.
In vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds
Chem. Biol. Drug Des.
77
494-499
2011
Homo sapiens
Isik, S.; Guler, O.O.; Kockar, F.; Aydin, M.; Arslan, O.; Supuran, C.T.
Saccharomyces cerevisiae beta-carbonic anhydrase: inhibition and activation studies
Curr. Pharm. Des.
16
3327-3336
2010
Saccharomyces cerevisiae
Ceyhun, S.B.; Sentuerk, M.; Yerlikaya, E.; Erdogan, O.; Kuefrevioglu, O.I.; Ekinci, D.
Purification and characterization of carbonic anhydrase from the teleost fish Dicentrarchus labrax (European seabass) liver and toxicological effects of metals on enzyme activity
Environ. Toxicol. Pharmacol.
32
69-74
2011
Dicentrarchus labrax
Sharma, A.; Bhattacharya, A.; Shrivastava, A.
Biomimetic CO2 sequestration using purified carbonic anhydrase from indigenous bacterial strains immobilized on biopolymeric materials
Enzyme Microb. Technol.
48
416-426
2011
Micrococcus luteus, Micrococcus lylae, Pseudomonas fragi, Micrococcus luteus 2
Kolayli, S.; Karahalil, F.; Sahin, H.; Dincer, B.; Supuran, C.T.
Characterization and inhibition studies of an alpha-carbonic anhydrase from the endangered sturgeon species Acipenser gueldenstaedti
J. Enzyme Inhib. Med. Chem.
26
895-900
2011
Acipenser gueldenstaedtii
Sharma, A.; Bhattacharya, A.
Enhanced biomimetic sequestration of CO2 into CaCO3 using purified carbonic anhydrase from indigenous bacterial strains
J. Mol. Catal. B
67
122-128
2010
Bos taurus, Micrococcus luteus, Micrococcus lylae, Pseudomonas fragi, Micrococcus luteus 2
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Fasseas, M.K.; Tsikou, D.; Flemetakis, E.; Katinakis, P.
Molecular and biochemical analysis of the alpha class carbonic anhydrases in Caenorhabditis elegans
Mol. Biol. Rep.
38
1777-1785
2011
Caenorhabditis elegans
Dave, K.; Scozzafava, A.; Vullo, D.; Supuran, C.T.; Ilies, M.A.
Pyridinium derivatives of histamine are potent activators of cytosolic carbonic anhydrase isoforms I, II and VII
Org. Biomol. Chem.
9
2790-2800
2011
Homo sapiens
Amata, O.; Marino, T.; Russo, N.; Toscano, M.
Catalytic activity of a zeta-class zinc and cadmium containing carbonic anhydrase. Compared work mechanisms
Phys. Chem. Chem. Phys.
13
3468-3477
2011
Methanosarcina thermophila, Conticribra weissflogii
Wang, M.; Sang, M.; Li, A.; Zhang, C.; Yang, Y.
Effects of physical and chemical factors on carbonic anhydrase activity of Haematococcus pluvialis CG-11
Plant Physiol. Commun.
46
701-706
2010
Haematococcus lacustris, Haematococcus lacustris CG-11
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Wandernoth, P.M.; Raubuch, M.; Mannowetz, N.; Becker, H.M.; Deitmer, J.W.; Sly, W.S.; Wennemuth, G.
Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm
PLoS ONE
5
e15061
2010
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Zimmerman, S.; Domsic, J.F.; Tu, C.; Robbins, A.H.; McKenna, R.; Silverman, D.N.; Ferry, J.G.
Role of Trp19 and Tyr200 in catalysis by the gamma-class carbonic anhydrase from Methanosarcina thermophila
Arch. Biochem. Biophys.
529
11-17
2013
Methanosarcina thermophila (P40881), Methanosarcina thermophila
Innocenti, A.; Zimmerman. S.; Ferry, J.G.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of the zinc and cobalt gamma-class enzyme from the archaeon Methanosarcina thermophila with anions
Bioorg. Med. Chem. Lett.
14
3327-3331
2004
Methanosarcina thermophila, Methanosarcina thermophila (P40881)
Innocenti, A.; Zimmerman, S.; Ferry, J.G.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions
Bioorg. Med. Chem. Lett.
14
4563-4567
2004
Methanothermobacter thermautotrophicus
Zimmerman, S.; Innocenti, A.; Casini, A.; Ferry, J.G.; Scozzafava, A.; Supuran, C.T.
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides
Bioorg. Med. Chem. Lett.
14
6001-6006
2004
Methanothermobacter thermautotrophicus, Methanosarcina thermophila (P40881), Methanosarcina thermophila
Kisker, C.; Schindelin, H.; Alber, B.E.; Ferry, J.G.; Rees, D.C.
A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila
EMBO J.
15
2323-2330
1996
Methanosarcina thermophila (P40881), Methanosarcina thermophila
Zimmerman, S.A.; Tomb, J.F.; Ferry, J.G.
Characterization of CamH from Methanosarcina thermophila, founding member of a subclass of the gamma class of carbonic anhydrases
J. Bacteriol.
192
1353-1360
2010
Methanosarcina thermophila (C3W4Q7), Methanosarcina thermophila TM-1 (C3W4Q7)
Tripp, B.C.; Bell, C.B.; Cruz, F.; Krebs, C.; Ferry, J.G.
A role for iron in an ancient carbonic anhydrase
J. Biol. Chem.
279
6683-6687
2004
Methanosarcina thermophila, Methanosarcina thermophila (P40881)
Simler, B.R.; Doyle, B.L.; Matthews, C.R.
Zinc binding drives the folding and association of the homo-trimeric gamma-carbonic anhydrase from Methanosarcina thermophila
Protein Eng. Des. Sel.
17
285-291
2004
Methanosarcina thermophila
Boone, C.D.; Habibzadegan, A.; Tu, C.; Silverman, D.N.; McKenna, R.
Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond
Acta Crystallogr. Sect. D
69
1414-1422
2013
Homo sapiens (P00918), Homo sapiens
Iqbal, S.; Nisar-ur-Rahman, S.; Iqbal, J.
A capillary electrophoresis-based enzyme assay for kinetics and inhibition studies of carbonic anhydrase
Anal. Biochem.
444
16-21
2014
Bos taurus
Kanth, B.K.; Min, K.; Kumari, S.; Jeon, H.; Jin, E.S.; Lee, J.; Pack, S.P.
Expression and characterization of codon-optimized carbonic anhydrase from Dunaliella species for CO(2) sequestration application
Appl. Biochem. Biotechnol.
167
2341-2356
2012
Dunaliella
Tu, C.; Foster, L.; Alvarado, A.; McKenna, R.; Silverman, D.N.; Frost, S.C.
Role of zinc in catalytic activity of carbonic anhydrase IX
Arch. Biochem. Biophys.
521
90-94
2012
Homo sapiens
West, D.; Kim, C.U.; Tu, C.; Robbins, A.H.; Gruner, S.M.; Silverman, D.N.; McKenna, R.
Structural and kinetic effects on changes in the CO(2) binding pocket of human carbonic anhydrase II
Biochemistry
51
9156-9163
2012
Homo sapiens
Akdemir, A.; Vullo, D.; De Luca, V.; Scozzafava, A.; Carginale, V.; Rossi, M.; Supuran, C.T.; Capasso, C.
The extremo-alpha-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines
Bioorg. Med. Chem. Lett.
23
1087-1090
2013
Sulfurihydrogenibium azorense
Monti, S.M.; De Simone, G.; Dathan, N.A.; Ludwig, M.; Vullo, D.; Scozzafava, A.; Capasso, C.; Supuran, C.T.
Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis
Bioorg. Med. Chem. Lett.
23
1626-1630
2013
Flaveria bidentis
Del Prete, S.; Vullo, D.; De Luca, V.; Carginale, V.; Scozzafava, A.; Supuran, C.T.; Capasso, C.
A highly catalytically active alpha-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules
Bioorg. Med. Chem. Lett.
23
4067-4071
2013
Porphyromonas gingivalis
Ohradanova, A.; Vullo, D.; Pastorekova, S.; Pastorek, J.; Jackson, D.J.; Woerheide, G.; Supuran, C.T.
Cloning, characterization and sulfonamide inhibition studies of an alpha-carbonic anhydrase from the living fossil sponge Astrosclera willeyana
Bioorg. Med. Chem.
20
1403-1410
2012
Astrosclera willeyana
Turkoglu, S.; Maresca, A.; Alper, M.; Kockar, F.; Isik, S.; Sinan, S.; Ozensoy, O.; Arslan, O.; Supuran, C.T.
Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors
Bioorg. Med. Chem.
20
2208-2213
2012
Homo sapiens
Demirdag, R.; Comakli, V.; Sentuerk, M.; Ekinci, D.;Irfan Kuefrevioglu, O.e.; Supuran, C.T.
Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity
Bioorg. Med. Chem.
21
1522-1525
2013
Ovis aries
Del Prete, S.; Vullo, D.; Scozzafava, A.; Capasso, C.; Supuran, C.T.
Cloning, characterization and anion inhibition study of the delta-class carbonic anhydrase (TweCA) from the marine diatom Thalassiosira weissflogii
Bioorg. Med. Chem.
22
531-537
2014
Conticribra weissflogii
Weise, A.; Schneider, H.P.; McKenna, R.; Deitmer, J.W.
Substrate-dependent interference of carbonic anhydrases with the glutamine transporter SNAT3-induced conductance
Cell. Physiol. Biochem.
27
79-90
2011
Escherichia coli
Russo, M.E.; Olivieri, G.; Capasso, C.; De Luca, V.; Marzocchella, A.; Salatino, P.; Rossi, M.
Kinetic study of a novel thermo-stable alpha-carbonic anhydrase for biomimetic CO2 capture
Enzyme Microb. Technol.
53
271-277
2013
Sulfurihydrogenibium yellowstonense, Sulfurihydrogenibium yellowstonense YO3AOP1
Lehneck, R.; Neumann, P.; Vullo, D.; Elleuche, S.; Supuran, C.T.; Ficner, R.; Poeggeler, S.
Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora
FEBS J.
281
1759-1772
2014
Sordaria macrospora (C1L335), Sordaria macrospora (C1L336)
Kumar, R.S.; Hendrick, W.; Correll, J.B.; Patterson, A.D.; Melville, S.B.; Ferry, J.G.
Biochemistry and physiology of the beta class carbonic anhydrase (Cpb) from Clostridium perfringens strain 13
J. Bacteriol.
195
2262-2269
2013
Clostridium perfringens
Ozensoy, O.; Arslan, M.; Supuran, C.T.
Carbonic anhydrase inhibitors: purification and inhibition studies of pigeon (Columba livia var. domestica) red blood cell carbonic anhydrase with sulfonamides
J. Enzyme Inhib. Med. Chem.
26
749-753
2011
Columba livia
Capasso, C.; De Luca, V.; Carginale, V.; Cannio, R.; Rossi, M.
Biochemical properties of a novel and highly thermostable bacterial alpha-carbonic anhydrase from Sulfurihydrogenibium yellowstonense YO3AOP1
J. Enzyme Inhib. Med. Chem.
27
892-897
2012
Sulfurihydrogenibium yellowstonense, Sulfurihydrogenibium yellowstonense YO3AO81
Del Prete, S.; Isik, S.; Vullo, D.; De Luca, V.; Carginale, V.; Scozzafava, A.; Supuran, C.T.; Capasso, C.
DNA cloning, characterization, and inhibition studies of an alpha-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae
J. Med. Chem.
55
10742-10748
2012
Vibrio cholerae serotype O1
Pan, P.; Vermelho, A.B.; Capaci Rodrigues, G.; Scozzafava, A.; Tolvanen, M.E.; Parkkila, S.; Capasso, C.; Supuran, C.T.
Cloning, characterization, and sulfonamide and thiol inhibition studies of an alpha-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease
J. Med. Chem.
56
1761-1771
2013
Trypanosoma cruzi, Malassezia globosa
Syrjaenen, L.; Vermelho, A.B.; Rodrigues, I.d.e..A.; Corte-Real, S.; Salonen, T.; Pan, P.; Vullo, D.; Parkkila, S.; Capasso, C.; Supuran, C.T.
Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis
J. Med. Chem.
56
7372-7381
2013
Leishmania chagasi
Al-Samir, S.; Papadopoulos, S.; Scheibe, R.J.; Meissner, J.D.; Cartron, J.P.; Sly, W.S.; Alper, S.L.; Gros, G.; Endeward, V.
Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1
J. Physiol.
591
4963-4982
2013
Homo sapiens
Ignatova, L.K.; Rudenko, N.N.; Mudrik, V.A.; Fedorchuk, T.P.; Ivanov, B.N.
Carbonic anhydrase activity in Arabidopsis thaliana thylakoid membrane and fragments enriched with PSI or PSII
Photosynth. Res.
110
89-98
2011
Arabidopsis thaliana
de Araujo, C.; Arefeen, D.; Tadesse, Y.; Long, B.M.; Price, G.D.; Rowlett, R.S.; Kimber, M.S.; Espie, G.S.
Identification and characterization of a carboxysomal gamma-carbonic anhydrase from the cyanobacterium Nostoc sp. PCC 7120
Photosynth. Res.
121
135-150
2014
Nostoc sp., Nostoc sp. PCC 7120
Hopkinson, B.M.; Meile, C.; Shen, C.
Quantification of extracellular carbonic anhydrase activity in two marine diatoms and investigation of its role
Plant Physiol.
162
1142-1152
2013
Thalassiosira pseudonana, Conticribra weissflogii
Fisher, Z.; Boone, C.D.; Biswas, S.M.; Venkatakrishnan, B.; Aggarwal, M.; Tu, C.; Agbandje-McKenna, M.; Silverman, D.; McKenna, R.
Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II
Protein Eng. Des. Sel.
25
347-355
2012
Homo sapiens (P00918), Homo sapiens
Idrees, D.; Kumar, S.; Rehman, S.A.A.; Gourinath, S.; Islam, A.; Ahmad, F.; Imtaiyaz Hassan, M.
Cloning, expression, purification and characterization of human mitochondrial carbonic anhydrase VA
3 Biotech
6
16
2016
Homo sapiens (P35218), Homo sapiens
Diaz-Torres, N.A.; Mahon, B.P.; Boone, C.D.; Pinard, M.A.; Tu, C.; Ng, R.; Agbandje-McKenna, M.; Silverman, D.; Scott, K.; McKenna, R.
Structural and biophysical characterization of the alpha-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2 insights into engineering thermostable enzymes for CO2 sequestration
Acta Crystallogr. Sect. D
71
1745-1756
2015
Hydrogenovibrio crunogenus (Q31FD6), Hydrogenovibrio crunogenus XCL-2 (Q31FD6), Hydrogenovibrio crunogenus XCL-2
Piazzetta, P.; Marino, T.; Russo, N.
Theoretical investigation on the restoring step of the carbonic anhydrase catalytic cycle for natural and promiscuous substrates
Arch. Biochem. Biophys.
582
101-106
2015
Homo sapiens (P00918), Homo sapiens
Koruza, K.; Lafumat, B.; Vegvari, A.; Knecht, W.; Fisher, S.Z.
Deuteration of human carbonic anhydrase for neutron crystallography Cell culture media, protein thermostability, and crystallization behavior
Arch. Biochem. Biophys.
645
26-33
2018
Homo sapiens (P00918), Homo sapiens (Q16790), Homo sapiens
Bian, Y.; Guo, C.; Chang, T.
Temperature stability of poly-[hemoglobin-superoxide dismutase-catalase-carbonic anhydrase] in the form of a solution or in the lyophilized form during storage at -80°C, 4°C, 25°C and 37°C or pasteurization at 70°C
Artif. Cells Nanomed. Biotechnol.
44
41-47
2016
Homo sapiens
Peirce, S.; Russo, M.; Perfetto, R.; Capasso, C.; Rossi, M.; Fernandez-Lafuente, R.; Salatino, P.; Marzocchella, A.
Kinetic characterization of carbonic anhydrase immobilized on magnetic nanoparticles as biocatalyst for CO2 capture
Biochem. Eng. J.
138
1-11
2018
Caminibacter sp.
McGurn, L.D.; Moazami-Goudarzi, M.; White, S.A.; Suwal, T.; Brar, B.; Tang, J.Q.; Espie, G.S.; Kimber, M.S.
The structure, kinetics and interactions of the beta-carboxysomal beta-carbonic anhydrase, CcaA
Biochem. J.
473
4559-4572
2016
Synechocystis sp. PCC 6803 (P72758), Synechocystis sp. PCC 6803 / Kazusa (Q54735)
Pinter, T.B.; Stillman, M.J.
Kinetics of zinc and cadmium exchanges between metallothionein and carbonic anhydrase
Biochemistry
54
6284-6293
2015
Bos taurus (P00921)
Iqbal, S.; Saleem, M.; Azim, M.K.; Taha, M.; Salar, U.; Khan, K.M.; Perveen, S.; Choudhary, M.I.
Carbohydrazones as new class of carbonic anhydrase inhibitors synthesis, kinetics, and ligand docking studies
Bioorg. Chem.
72
89-101
2017
Bos taurus (P00921)
De Luca, V.; Vullo, D.; Del Prete, S.; Carginale, V.; Scozzafava, A.; Osman, S.M.; AlOthman, Z.; Supuran, C.T.; Capasso, C.
Cloning, characterization and anion inhibition studies of a new gamma-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis
Bioorg. Med. Chem.
23
4405-4409
2015
Pseudoalteromonas haloplanktis ANT/505 (F3BJI2)
De Luca, V.; Vullo, D.; Del Prete, S.; Carginale, V.; Osman, S.M.; AlOthman, Z.; Supuran, C.T.; Capasso, C.
Cloning, characterization and anion inhibition studies of a gamma-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea
Bioorg. Med. Chem.
24
835-840
2016
Colwellia psychrerythraea (Q47YG3), Colwellia psychrerythraea, Colwellia psychrerythraea 34H / ATCC BAA-681 (Q47YG3)
De Simone, G.; Monti, S.M.; Alterio, V.; Buonanno, M.; De Luca, V.; Rossi, M.; Carginale, V.; Supuran, C.T.; Capasso, C.; Di Fiore, A.
Crystal structure of the most catalytically effective carbonic anhydrase enzyme known, SazCA from the thermophilic bacterium Sulfurihydrogenibium azorense
Bioorg. Med. Chem. Lett.
25
2002-2006
2015
Sulfurihydrogenibium azorense (C1DTU5), Sulfurihydrogenibium azorense, Sulfurihydrogenibium azorense Az-Fu1 / DSM 15241 / OCM 825 (C1DTU5)
De Luca, V.; Del Prete, S.; Carginale, V.; Vullo, D.; Supuran, C.T.; Capasso, C.
Cloning, characterization and anion inhibition studies of a gamma-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune
Bioorg. Med. Chem. Lett.
25
4970-4975
2015
Nostoc commune
Del Prete, S.; Vullo, D.; De Luca, V.; Carginale, V.; Osman, S.M.; AlOthman, Z.; Supuran, C.T.; Capasso, C.
Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum
Bioorg. Med. Chem. Lett.
26
4184-4190
2016
Plasmodium falciparum (Q8IHW5), Plasmodium falciparum
Jun, S.Y.; Kim, S.H.; Kanth, B.K.; Lee, J.; Pack, S.P.
Expression and characterization of a codon-optimized alkaline-stable carbonic anhydrase from Aliivibrio salmonicida for CO2 sequestration applications
Bioprocess Biosyst. Eng.
40
413-421
2017
Aliivibrio salmonicida (B6EIU7), Aliivibrio salmonicida
Langella, E.; Buonanno, M.; Vullo, D.; Dathan, N.; Leone, M.; Supuran, C.T.; De Simone, G.; Monti, S.M.
Biochemical, biophysical and molecular dynamics studies on the proteoglycan-like domain of carbonic anhydrase IX
Cell. Mol. Life Sci.
75
3283-3296
2018
Homo sapiens (Q16790), Homo sapiens
Bhatt, A.; Mahon, B.P.; Cruzeiro, V.W.; Cornelio, B.; Laronze-Cochard, M.; Ceruso, M.; Sapi, J.; Rance, G.A.; Khlobystov, A.N.; Fontana, A.; Roitberg, A.; Supuran, C.T.; McKenna, R.
Structure-activity relationships of benzenesulfonamide-based inhibitors towards carbonic anhydrase isoform specificity
ChemBioChem
18
213-222
2017
Homo sapiens (O43570), Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (Q16790)
Esbaugh, A.J.; Secor, S.M.; Grosell, M.
Characterization of carbonic anhydrase XIII in the erythrocytes of the Burmese python, Python molurus bivittatus
Comp. Biochem. Physiol. B
187
71-77
2015
Python bivittatus
Faridi, S.; Satyanarayana, T.
Novel alkalistable alpha-carbonic anhydrase from the polyextremophilic bacterium Bacillus halodurans characteristics and applicability in flue gas CO2 sequestration
Environ. Sci. Pollut. Res. Int.
23
15236-15249
2016
Halalkalibacterium halodurans (A0A0N9WRG3), Halalkalibacterium halodurans TSLV1 / MTCC 10961 (A0A0N9WRG3)
Kucuk, M.; Gulcin, I.
Purification and characterization of the carbonic anhydrase enzyme from Black Sea trout (Salmo trutta Labrax Coruhensis) kidney and inhibition effects of some metal ions on enzyme activity
Environ. Toxicol. Pharmacol.
44
134-139
2016
Salmo trutta Labrax Coruhensis
Chiaramonte, N.; Bua, S.; Ferraroni, M.; Nocentini, A.; Bonardi, A.; Bartolucci, G.; Durante, M.; Lucarini, L.; Chiapponi, D.; Dei, S.; Manetti, D.; Teodori, E.; Gratteri, P.; Masini, E.; Supuran, C.T.; Romanelli, M.N.
2-Benzylpiperazine a new scaffold for potent human carbonic anhydrase inhibitors. Synthesis, enzyme inhibition, enantioselectivity, computational and crystallographic studies and in vivo activity for a new class of intraocular pressure lowering agents
Eur. J. Med. Chem.
151
363-375
2018
Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (P22748), Homo sapiens (Q16790), Homo sapiens
Feng, H.Z.; Jin, J.P.
Carbonic anhydrase III is expressed in mouse skeletal muscles independent of fiber type-specific myofilament protein isoforms and plays a role in fatigue resistance
Front. Physiol.
7
597
2016
Mus musculus (P16015), Mus musculus, Mus musculus 129SEVE (P16015)
Koh, C.Z.Y.; Hiong, K.C.; Choo, C.Y.L.; Boo, M.V.; Wong, W.P.; Chew, S.F.; Neo, M.L.; Ip, Y.K.
Molecular characterization of a dual domain carbonic anhydrase from the ctenidium of the giant clam, Tridacna squamosa, and its expression levels after light exposure, cellular localization, and possible role in the uptake of exogenous inorganic carbon
Front. Physiol.
9
281
2018
Tridacna squamosa (A0A2R2Y2Q1), Tridacna squamosa
Wang, G.L.; Wang, Q.; Xu, Z.C.; Wang, Y.Y.; Li, J.L.
Identification, structural characterization and expression analysis of a novel carbonic anhydrase from freshwater mussel Hyriopsis cumingii
Gene
636
78-86
2017
Hyriopsis cumingii (A0A220A4U9), Hyriopsis cumingii
Sumi, K.R.; Kim, S.C.; Natarajan, S.; Choi, K.S.; Choi, M.R.; Kim, H.T.; Park, J.I.; Nou, I.S.; Gilmour, K.M.; Kho, K.H.
Molecular cloning and characterization of secretory carbonic anhydrase VI in pufferfish (Takifugu rubripes)
Gene
640
57-65
2018
Takifugu rubripes (A0A2D1CFJ9)
Faridi, S.; Satyanarayana, T.
Characteristics of recombinant alpha-carbonic anhydrase of polyextremophilic bacterium Bacillus halodurans TSLV1
Int. J. Biol. Macromol.
89
659-668
2016
Halalkalibacterium halodurans (A0A0N9WRG3), Halalkalibacterium halodurans TSLV1 (A0A0N9WRG3)
Wahiduzzaman, C.T.; Dar, M.A.; Haque, M.A.; Idrees, D.; Hassan, M.I.; Islam, A.; Ahmad, F.
Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II
Int. J. Biol. Macromol.
95
881-887
2017
Homo sapiens (P00918), Homo sapiens
Di Fiore, A.; Alterio, V.; Monti, S.M.; De Simone, G.; D'Ambrosio, K.
Thermostable carbonic anhydrases in biotechnological applications
Int. J. Mol. Sci.
16
15456-15480
2015
Methanosarcina thermophila, Sulfurihydrogenibium azorense, Citrobacter freundii (A0A0D7LLM5), Caminibacter mediatlanticus (A6DAW8), Sulfurihydrogenibium sp. YO3AOP1 (B2V8E3), Persephonella marina (C0QRB5), Methanothermobacter thermautotrophicus (D9PU79), Thermovibrio ammonificans (E8T502), Serratia sp. ISTD04 (K4N028), Pyrococcus horikoshii (O59257), Homo sapiens (P00918), Bos taurus (P00921), Desulfovibrio vulgaris (Q72B61), Caminibacter mediatlanticus TB-2 (A6DAW8), Desulfovibrio vulgaris Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303 (Q72B61), Persephonella marina DSM 14350 / EX-H1 (C0QRB5), Methanothermobacter thermautotrophicus ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg (D9PU79), Thermovibrio ammonificans DSM 15698 / JCM 12110 / HB-1 (E8T502)
Demirdag, R.; Comakli, V.; Kuzu, M.; Yerlikaya, E.; Sentuerk, M.
Purification and characterization of carbonic anhydrase from Agri Balik Lake trout gill (Salmo trutta labrax) and effects of sulfonamides on enzyme activity
J. Biochem. Mol. Toxicol.
29
123-128
2015
Salmo labrax
Huyut, Z.; Beydemir, S.; Guelcin, I.
Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes
J. Biochem. Mol. Toxicol.
31
e21930
2017
Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens
Kocyigit, U.M.; Dastan, S.D.; Taslimi, P.; Dastan, T.; Gulcin, I.
Inhibitory effects of some drugs on carbonic anhydrase enzyme purified from Kangal Akkaraman sheep in Sivas, Turkey
J. Biochem. Mol. Toxicol.
32
e22000
2017
Ovis aries, Ovis aries Kangal Akkaraman
Kocyigit, U.M.; Taslimi, P.; Gulcin, I.
Characterization and inhibition effects of some metal ions on carbonic anhydrase enzyme from Kangal Akkaraman sheep
J. Biochem. Mol. Toxicol.
32
e22172
2018
Ovis aries, Ovis aries Kangal Akkaraman
Juozapaitiene, V.; Bartkute, B.; Michailoviene, V.; Zaksauskas, A.; Baranauskiene, L.; Satkune, S.; Matulis, D.
Purification, enzymatic activity and inhibitor discovery for recombinant human carbonic anhydrase XIV
J. Biotechnol.
240
31-42
2016
Homo sapiens (Q9ULX7), Homo sapiens
Del Prete, S.; Vullo, D.; De Luca, V.; Supuran, C.T.; Capasso, C.
Biochemical characterization of the delta-carbonic anhydrase from the marine diatom Thalassiosira weissflogii, TweCA
J. Enzyme Inhib. Med. Chem.
29
906-911
2014
Conticribra weissflogii (Q5U9J1), Conticribra weissflogii
Del Prete, S.; Vullo, D.; De Luca, V.; AlOthman, Z.; Osman, S.M.; Supuran, C.T.; Capasso, C.
Biochemical characterization of recombinant beta-carbonic anhydrase (PgiCAb) identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis
J. Enzyme Inhib. Med. Chem.
30
366-370
2015
Porphyromonas gingivalis (B2RL07), Porphyromonas gingivalis, Porphyromonas gingivalis ATCC 33277 (B2RL07)
Eminoglu, A.; Vullo, D.; Asik, A.; Colak, D.N.; Supuran, C.T.; Canakci, S.; Osman Belduez, A.
Cloning, expression and biochemical characterization of a beta-carbonic anhydrase from the soil bacterium Enterobacter sp. B13
J. Enzyme Inhib. Med. Chem.
31
1111-1118
2016
Enterobacter sp. B13 (A0A0S1NK17)
Orhan, F.; Sentuerk, M.; Supuran, C.T.
Interaction of anions with a newly characterized alpha carbonic anhydrase from Halomonas sp.
J. Enzyme Inhib. Med. Chem.
31
1119-1123
2016
Halomonas sp.
Durdagi, S.; Korkmaz, N.; Isik, S.; Vullo, D.; Astley, D.; Ekinci, D.; Salmas, R.E.; Senturk, M.; Supuran, C.T.
Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds
J. Enzyme Inhib. Med. Chem.
31
1214-1220
2016
Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (Q16790), Homo sapiens
Kuecuekbay, F.Z.; Bugday, N.; Kuecuekbay, H.; Tanc, M.; Supuran, C.T.
Synthesis, characterization and carbonic anhydrase inhibitory activity of novel benzothiazole derivatives
J. Enzyme Inhib. Med. Chem.
31
1221-1225
2016
Homo sapiens (O43570), Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens (P22748), Homo sapiens
Del Prete, S.; De Luca, V.; De Simone, G.; Supuran, C.T.; Capasso, C.
Cloning, expression and purification of the complete domain of the eta-carbonic anhydrase from Plasmodium falciparum
J. Enzyme Inhib. Med. Chem.
31
54-59
2016
Plasmodium falciparum (Q8IHW5), Plasmodium falciparum
Perfetto, R.; Del Prete, S.; Vullo, D.; Carginale, V.; Sansone, G.; Barone, C.M.A.; Rossi, M.; Alasmary, F.A.S.; Osman, S.M.; AlOthman, Z.; Supuran, C.T.; Capasso, C.
Cloning, expression and purification of the alpha-carbonic anhydrase from the mantle of the Mediterranean mussel, Mytilus galloprovincialis
J. Enzyme Inhib. Med. Chem.
32
1029-1035
2017
Mytilus galloprovincialis (A0A0N9FGL8), Mytilus galloprovincialis
Soydan, E.; Gueler, A.; Biyik, S.; Sentuerk, M.; Supuran, C.T.; Ekinci, D.
Carbonic anhydrase from Apis mellifera purification and inhibition by pesticides
J. Enzyme Inhib. Med. Chem.
32
47-50
2017
Apis mellifera
Perfetto, R.; Del Prete, S.; Vullo, D.; Sansone, G.; Barone, C.; Rossi, M.; Supuran, C.T.; Capasso, C.
Biochemical characterization of the native alpha-carbonic anhydrase purified from the mantle of the Mediterranean mussel, Mytilus galloprovincialis
J. Enzyme Inhib. Med. Chem.
32
632-639
2017
Mytilus galloprovincialis (A0A0N9FGL8), Mytilus galloprovincialis
Alper Tuerkoglu, E.; Sentuerk, M.; Supuran, C.T.; Ekinci, D.
Carbonic anhydrase inhibitory properties of some uracil derivatives
J. Enzyme Inhib. Med. Chem.
32
74-77
2017
Homo sapiens (P00915), Homo sapiens (P00918), Homo sapiens
Bouchouit, M.; Bouacida, S.; Zouchoune, B.; Merazig, H.; Bua, S.; Bouaziz, Z.; Le Borgne, M.; Supuran, C.T.; Bouraiou, A.
Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes
J. Enzyme Inhib. Med. Chem.
33
1150-1159
2018
Homo sapiens (P00915), Homo sapiens (P00918)
Moeker, J.; Mahon, B.P.; Bornaghi, L.F.; Vullo, D.; Supuran, C.T.; McKenna, R.; Poulsen, S.A.
Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates
J. Med. Chem.
57
8635-8645
2014
Homo sapiens (Q16790)
Karakostis, K.; Costa, C.; Zito, F.; Bruemmer, F.; Matranga, V.
Characterization of an alpha type carbonic anhydrase from Paracentrotus lividus sea urchin embryos
Mar. Biotechnol.
18
384-395
2016
Paracentrotus lividus (A0A193PYR8), Paracentrotus lividus
Bhatt, A.; Mondal, U.K.; Supuran, C.T.; Ilies, M.A.; McKenna, R.
Crystal structure of carbonic anhydrase II in complex with an activating ligand implications in neuronal function
Mol. Neurobiol.
55
7431-7437
2018
Homo sapiens (P00918), Homo sapiens
Warden, A.C.; Williams, M.; Peat, T.S.; Seabrook, S.A.; Newman, J.; Dojchinov, G.; Haritos, V.S.
Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst
Nat. Commun.
6
10278
2015
Homo sapiens (P00918)
Cau, Y.; Mori, M.; Supuran, C.T.; Botta, M.
Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters kinetic and computational investigations
Org. Biomol. Chem.
14
8322-8330
2016
Mycobacterium tuberculosis (P96878), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P96878), Mycobacterium tuberculosis ATCC 25618 (P96878)
Patrikainen, M.S.; Tolvanen, M.E.E.; Aspatwar, A.; Barker, H.R.; Ortutay, C.; Jaenis, J.; Laitaoja, M.; Hytoenen, V.P.; Azizi, L.; Manandhar, P.; Jager, E.; Vullo, D.; Kukkurainen, S.; Hilvo, M.; Supuran, C.T.; Parkkila, S.
Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase
PeerJ
5
e4128
2017
Danio rerio (E7F742), Danio rerio
Karacan, M.S.; Rodionova, M.V.; Tunc, T.; Venedik, K.B.; Mamas, S.; Shitov, A.V.; Zharmukhamedov, S.K.; Klimov, V.V.; Karacan, N.; Allakhverdiev, S.I.
Characterization of nineteen antimony(III) complexes as potent inhibitors of photosystem II, carbonic anhydrase, and glutathione reductase
Photosynth. Res.
130
167-182
2016
Bos taurus (P00921), Pisum sativum (P17067)
Ip, Y.K.; Koh, C.Z.Y.; Hiong, K.C.; Choo, C.Y.L.; Boo, M.V.; Wong, W.P.; Neo, M.L.; Chew, S.F.
Carbonic anhydrase 2-like in the giant clam, Tridacna squamosa characterization, localization, response to light, and possible role in the transport of inorganic carbon from the host to its symbionts
Physiol. Rep.
5
e13494
2017
Tridacna squamosa (A0A2R2Y2Q1)
Soto, D.; Cordoba, J.P.; Villarreal, F.; Bartoli, C.; Schmitz, J.; Maurino, V.G.; Braun, H.P.; Pagnussat, G.C.; Zabaleta, E.
Functional characterization of mutants affected in the carbonic anhydrase domain of the respiratory complex I in Arabidopsis thaliana
Plant J.
83
831-844
2015
Arabidopsis thaliana (Q9C6B3), Arabidopsis thaliana (Q9FMV1), Arabidopsis thaliana (Q9FWR5), Arabidopsis thaliana (Q9SMN1), Arabidopsis thaliana
Benlloch, R.; Shevela, D.; Hainzl, T.; Grundstroem, C.; Shutova, T.; Messinger, J.; Samuelsson, G.; Sauer-Eriksson, A.E.
Crystal structure and functional characterization of photosystem II-associated carbonic anhydrase CAH3 in Chlamydomonas reinhardtii
Plant Physiol.
167
950-962
2015
Chlamydomonas reinhardtii (A8J4Z8), Chlamydomonas reinhardtii
Kanth, B.; Jun, S.; Kumari, S.; Pack, S.
Highly thermostable carbonic anhydrase from Persephonella marina EX-H1 its expression and characterization for CO2-sequestration applications
Process Biochem.
49
2114-2121
2014
Persephonella marina (C0QRB5), Persephonella marina DSM 14350 / EX-H1 (C0QRB5)
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Al-Dhrub, A.; Sahin, S.; Ozmen, I.; Tunca, E.; Bulbul, M.
Immobilization and characterization of human carbonic anhydrase I on amine functionalized magnetic nanoparticles
Process Biochem.
57
95-104
2017
Homo sapiens (P00915)
-
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