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acetazolamide
highly inhibited by acetazolamide, i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide
((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methyl sulfamate
-
-
(6S)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
1,2-benzothiazol-3(2H)-one 1,1-dioxide
-
-
1-(1,2-benzoxazol-3-yl)methanesulfonamide
-
-
2-aminobenzenesulfonamide
-
-
2-hydrazinylbenzenesulfonamide
-
-
3-(4-sulfamoylphenyl)propanoic acid
-
-
4,5-dichlorobenzene-1,3-disulfonamide
-
-
4-(1,1-dioxido-1,2-thiazinan-2-yl)benzenesulfonamide
-
-
4-(2-aminoethyl)benzenesulfonamide
-
-
4-(2-hydroxyethyl)benzenesulfonamide
-
-
4-(aminomethyl)benzenesulfonamide
-
-
4-(ethylamino)-6-(3-methoxypropyl)-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
-
-
4-(hydroxymethyl)benzenesulfonamide
-
-
4-amino-3,5-dibromobenzenesulfonamide
-
-
4-amino-3,5-diiodobenzenesulfonamide
-
-
4-amino-3-bromobenzenesulfonamide
-
-
4-amino-3-chlorobenzenesulfonamide
-
-
4-amino-3-fluorobenzenesulfonamide
-
-
4-amino-3-iodobenzenesulfonamide
-
-
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
-
4-amino-6-chlorobenzene-1,3-disulfonamide
-
-
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
-
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
-
4-Aminobenzenesulfonamide
-
-
4-hydrazinylbenzenesulfonamide
-
-
4-methylbenzenesulfonamide
-
-
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
-
-
4-sulfamoylbenzoic acid
-
-
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
-
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
-
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
-
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[(phenylsulfonyl)amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
-
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
-
6-ethoxy-1,3-benzothiazole-2-sulfonamide
-
-
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
-
Carbonate
-
best inhibitor
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
-
-
N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
-
-
saccharin
-
effective STPCA inhibitor
sulfamate
-
best inhibitor
sulfate
-
-
sulfate
-
slight inhibition
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0.000016
acetazolamide
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.000553 - 0.000675
2-aminobenzenesulfonamide
0.00251
2-hydrazinylbenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000256
3-(4-sulfamoylphenyl)propanoic acid
-
in 10 mM HEPES (pH 7.4), at 25°C
0.0000943 - 0.000577
4-(2-aminoethyl)benzenesulfonamide
0.00077
4-(2-hydroxyethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.0000825 - 0.000508
4-(aminomethyl)benzenesulfonamide
0.000768
4-(hydroxymethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.00054
4-amino-3,5-dibromobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000695
4-amino-3,5-diiodobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000104
4-amino-3-bromobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.0000875 - 0.000551
4-amino-3-chlorobenzenesulfonamide
0.0000751 - 0.000493
4-amino-3-fluorobenzenesulfonamide
0.0000883
4-amino-3-iodobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000367 - 0.000481
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
0.000295 - 0.00084
4-amino-6-chlorobenzene-1,3-disulfonamide
0.0000298 - 0.000868
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
0.0000197 - 0.00065
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
0.0003 - 0.000364
4-Aminobenzenesulfonamide
0.000294
4-hydrazinylbenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000516 - 0.000614
4-methylbenzenesulfonamide
0.000902
4-sulfamoyl-N-[2-(4-sulfamoylphenyl)ethyl]benzamide
-
isozyme STPCA, pH 7.5, 20°C
0.000435
4-sulfamoylbenzoic acid
-
in 10 mM HEPES (pH 7.4), at 25°C
0.0000254 - 0.000642
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
0.000607
5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000105 - 0.000361
5-amino-1,3,4-thiadiazole-2-sulfonamide
0.0000919 - 0.000357
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
0.000661
5-[[(4-amino-3-chloro-5-fluorophenyl)sulfonyl]amino]-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000276 - 0.000333
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
0.000701
6-hydroxy-1,3-benzothiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000016 - 0.000074
acetazolamide
0.52
azide
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.0000204
benzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.45
bicarbonate
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.01
bisulfite
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.96
Br-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0000482
brinzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0097
bromide
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.45
Carbonate
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.0000342
celecoxib
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.5
chloride
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.53
Cl-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.86
CN-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.69
CNO-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.24
CO32-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.58
Cyanate
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.000431
dichlorophenamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000181
dorzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000394
ethoxzolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.92
F-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.62
fluoride
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.0057
H2NSO2NH2
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0085
H2NSO3H
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
7.81
HCO3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
3.94
HS-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.43
HSO3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.41
hydrogen sulfide
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
33
I-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.000163
indisulam
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.009
Iodide
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.59
isocyanide
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.0000212
methazolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
4.68
N3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.56
nitrate
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.77
nitrite
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
3.15
NO2-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.99
NO3-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0672
Ph-AsO3H2
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.0081
phenyl-boronic acid
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.78
phenylarsonic acid
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.68
phenylboronic acid
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.0000403
saccharin
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.51
SCN-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.33
SO42-
-
isozyme STPCA-2, pH not specified in the publication, temperature not specified in the publication
0.41
sulfamate
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.81
sulfamic acid
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.91
sulfate
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.00043
sulpiride
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000452
sulthiame
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.68
thiocyanate
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.0000291
topiramate
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.0000287
valdecoxib
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.000259
zonisamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.000553
2-aminobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000675
2-aminobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000943
4-(2-aminoethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000577
4-(2-aminoethyl)benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000825
4-(aminomethyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000508
4-(aminomethyl)benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000875
4-amino-3-chlorobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000551
4-amino-3-chlorobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000751
4-amino-3-fluorobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000493
4-amino-3-fluorobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000367
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000481
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000295
4-amino-6-chlorobenzene-1,3-disulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.00084
4-amino-6-chlorobenzene-1,3-disulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000298
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000868
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000197
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.00065
4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0003
4-Aminobenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000364
4-Aminobenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000516
4-methylbenzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000614
4-methylbenzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.0000254
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000642
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000105
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000361
5-amino-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000919
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000357
5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.0000276
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
in 10 mM HEPES (pH 7.4), at 25°C
0.000333
5-[[(4-aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide
-
isozyme STPCA, pH 7.5, 20°C
0.000016
acetazolamide
-
at 20°C and pH 7.5 in 10 mM HEPES buffer
0.000016
acetazolamide
-
in 10 mM HEPES (pH 7.4), 0.1 M Na2SO4 or NaClO4, at 25°C
0.000016
acetazolamide
-
isozyme STPCA, pH 7.5, 20°C
0.000074
acetazolamide
-
isozyme STPCA-2, pH 7.5, 20°C
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