Reference on EC 4.1.3.30 - Methylisocitrate lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Uchiyama, H.; Ando, M.; Toyonaka, Y.; Tabuchi, T.
Subcellular localization of the methylcitric-acid-cycle enzymes in propionate metabolism of Yarrowia lipolytica
Eur. J. Biochem.
125
523-527
1982
Yarrowia lipolytica
Tabuchi, T.; Igoshi, K.
Regulation of enzyme synthesis of the glycolate, the citric acid, and the methylcitric acid cycles in Candida lipolytica
Agric. Biol. Chem.
42
2381-2386
1978
Yarrowia lipolytica
-
Tabuchi, T.; Satoh, T.
Purification and properties of methylisocitrate lyase, a key enzyme in propionate metabolism, from Candida lipolytica
Agric. Biol. Chem.
41
169-174
1977
Yarrowia lipolytica
-
Tabuchi, T.; Satoh, T.
Distinction between isocitrate lyase and methylisocitrate lyase in Candida lipolytica
Agric. Biol. Chem.
40
1863-1869
1976
Yarrowia lipolytica
-
Miyakoshi, S.; Uchiyama, H.; Someya, T.; Satoh, T.; Tabuchi, T.
Distribution of the methylcitric acid cycle and beta-oxidation pathway for propionate catabolism in fungi
Agric. Biol. Chem.
51
2381-2387
1987
Aspergillus niger, Wickerhamiella pararugosa, Diutina rugosa, Mucor rouxianus, Neurospora crassa, Rhizopus microsporus var. chinensis, Ustilago crus-galli, Ustilago utriculosa, Rhizopus microsporus var. chinensis IAM 6003, Neurospora crassa IFO 6067, Mucor rouxianus IFO 5773, Ustilago utriculosa F-B-5, Diutina rugosa IFO 0750, Wickerhamiella pararugosa IFO 0966, Ustilago crus-galli F-B-6
-
Simanshu, D.K.; Satheshkumar, P.S.; Savithri, H.S.; Murthy, M.R.
Crystal structure of Salmonella typhimurium 2-methylisocitrate lyase (PrpB) and its complex with pyruvate and Mg(2+)
Biochem. Biophys. Res. Commun.
311
193-201
2003
Salmonella enterica subsp. enterica serovar Typhimurium
Brock, M.; Darley, D.; Textor, S.; Buckel, W.
2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes
Eur. J. Biochem.
268
3577-3586
2001
Aspergillus nidulans
Luttik, M.A.; Kotter, P.; Salomons, F.A.; van der Klei, I.J.; van Dijken, J.P.; Pronk, J.T.
The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism
J. Bacteriol.
182
7007-7013
2000
Saccharomyces cerevisiae
Grimek, T.L.; Holden, H.; Rayment, I.; Escalante-Semerena, J.C.
Residues C123 and D58 of the 2-methylisocitrate lyase (PrpB) enzyme of Salmonella enterica are essential for catalysis
J. Bacteriol.
185
4837-4843
2003
Salmonella enterica
Grimm, C.; Evers, A.; Brock, M.; Maerker, C.; Klebe, G.; Buckel, W.; Reuter, K.
Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre
J. Mol. Biol.
328
609-621
2003
Escherichia coli (P77541), Escherichia coli
Brock, M.
Generation and phenotypic characterization of Aspergillus nidulans methylisocitrate lyase deletion mutants: methylisocitrate inhibits growth and conidiation
Appl. Environ. Microbiol.
71
5465-5475
2005
Aspergillus nidulans
Liu, S.; Lu, Z.; Han, Y.; Melamud, E.; Dunaway-Mariano, D.; Herzberg, O.
Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution
Biochemistry
44
2949-2962
2005
Escherichia coli (P77541)
Upton, A.M.; McKinney, J.D.
Role of the methylcitrate cycle in propionate metabolism and detoxification in Mycobacterium smegmatis
Microbiology
153
3973-3982
2007
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
Munoz-Elias, E.J.; Upton, A.M.; Cherian, J.; McKinney, J.D.
Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence
Mol. Microbiol.
60
1109-1122
2006
Mycobacterium tuberculosis
Gould, T.A.; van de Langemheen, H.; Munoz-Elias, E.J.; McKinney, J.D.; Sacchettini, J.C.
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis
Mol. Microbiol.
61
940-947
2006
Mycobacterium tuberculosis
Lee, S.H.; Han, Y.K.; Yun, S.H.; Lee, Y.W.
Roles of the glyoxylate and methylcitrate cycles in sexual development and virulence in the cereal pathogen Gibberella zeae
Eukaryot. Cell
8
1155-1164
2009
Fusarium graminearum, Fusarium graminearum Z03643
Mueller, S.; Fleck, C.B.; Wilson, D.; Hummert, C.; Hube, B.; Brock, M.
Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases
Environ. Microbiol.
13
1534-1548
2011
Aspergillus fumigatus, Aspergillus fumigatus Af293
Dubey, M.K.; Broberg, A.; Jensen, D.F.; Karlsson, M.
Role of the methylcitrate cycle in growth, antagonism and induction of systemic defence responses in the fungal biocontrol agent Trichoderma atroviride
Microbiology
159
2492-2500
2013
Trichoderma atroviride, Trichoderma atroviride IMI206040
Limenitakis, J.; Oppenheim, R.D.; Creek, D.J.; Foth, B.J.; Barrett, M.P.; Soldati-Favre, D.
The 2-methylcitrate cycle is implicated in the detoxification of propionate in Toxoplasma gondii
Mol. Microbiol.
87
894-908
2013
Toxoplasma gondii (Q2L8W6), Toxoplasma gondii
Eoh, H.; Rhee, K.Y.
Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids
Proc. Natl. Acad. Sci. USA
111
4976-4981
2014
Mycobacterium tuberculosis
Reddick, J.J.; Sirkisoon, S.; Dahal, R.A.; Hardesty, G.; Hage, N.E.; Booth, W.T.; Quattlebaum, A.L.; Mills, S.N.; Meadows, V.G.; Adams, S.L.H.; Doyle, J.S.; Kiel, B.E.
First biochemical characterization of a methylcitric acid cycle from Bacillus subtilis strain 168
Biochemistry
56
5698-5711
2017
Bacillus subtilis (P54528), Bacillus subtilis 168 (P54528)
Pulaganti, M.; C M, A.; Kumar, C.S.
Design, synthesis, and evaluation of pyrazolo-pyrazole derivatives on methylisocitrate lyase of Pseudomonas aeruginosa in silico and in vitro study
J. Biomol. Struct. Dyn.
35
2509-2529
2017
Pseudomonas aeruginosa
Jongkon, N.; Chotpatiwetchkul, W.; Gleeson, M.P.
Probing the catalytic mechanism involved in the isocitrate lyase superfamily hybrid quantum mechanical/molecular mechanical calculations on 2,3-dimethylmalate lyase
J. Phys. Chem. B
119
11473-11484
2015
Mycobacterium tuberculosis
Lee, J.J.; Lim, J.; Gao, S.; Lawson, C.P.; Odell, M.; Raheem, S.; Woo, J.; Kang, S.H.; Kang, S.S.; Jeon, B.Y.; Eoh, H.
Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis
Sci. Rep.
8
8506
2018
Mycobacterium tuberculosis, Mycobacterium tuberculosis BCG
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