Information on EC 4.1.3.26 - 3-Hydroxy-3-isohexenylglutaryl-CoA lyase

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The expected taxonomic range for this enzyme is: Pseudomonas aeruginosa group

EC NUMBER
COMMENTARY hide
4.1.3.26
-
RECOMMENDED NAME
GeneOntology No.
3-Hydroxy-3-isohexenylglutaryl-CoA lyase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
elimination
-
-
of an oxo acid, C-C bond cleavage
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
cis-genanyl-CoA degradation
-
-
Geraniol degradation
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-
SYSTEMATIC NAME
IUBMB Comments
3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming)
Also acts on the hydroxy derivative of farnesoyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
37290-69-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
LiuE displays a bifunctional role in both the leucine/isovalerate and acyclic terpenes catabolic pathways, LiuE shows enzymatic activity of HMG-CoA lyase and also HIHG-CoA lyase activity
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-hydroxy-3-isohexenylglutaryl-CoA
7-methyl-3-oxo-6-octenyl-CoA + acetate
show the reaction diagram
-
-
-
?
Hydroxyisohexenylglutaryl-CoA
3-Ketoacyl-CoA derivative + acetate
show the reaction diagram
-
-
-
-
additional information
?
-
-
involved in the degradation of the branched carbon skeletons of geraniol and farnesol
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-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
involved in the degradation of the branched carbon skeletons of geraniol and farnesol
-
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33000
x * 33000, SDS-PAGE
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 33000, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
by affinity chromatography, more than 98% purified
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
His-tagged protein expressed in Escherichia coli JM101