Reference on EC 4.1.3.16 - 4-Hydroxy-2-oxoglutarate aldolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adams, E.
Enzymes and intermediates of hydroxyproline degradation
Methods Enzymol.
17B
266-306
1971
Rattus norvegicus
-
Taha, T.S.; Deits, T.L.
Purification and characterization of 2-keto-3-deoxy-6-phosphogluconate aldolase from Azotobacter vinelandii: evidence that the enzyme is bifunctional towards 2-keto-4-hydroxyglutarate cleavage
Biochem. Biophys. Res. Commun.
200
459-466
1994
Azotobacter vinelandii
Kuratomi, K.; Fukunaga, K.
The metabolism of gamma-hydroxyglutamate in rat liver. 1. Enzymic synthesis of gamma-hydroxy-alpha-ketoglutarate from pyruvate and glyoxylate
Biochim. Biophys. Acta
78
617-628
1963
Rattus norvegicus
Lane, R.S.; Shapley, A.; Dekker, E.E.
2-keto-4-Hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in mammalian metabolism of L-homoserine
Biochemistry
10
1353-1364
1971
Bos taurus, Mammalia
Kobes, R.D.; Dekker, E.E.
Variant properties of bovine liver 2-keto-4-hydroxyglutarate aldolase: its beta-decarboxylase activity, lack of substrate stereospecificity, and structural requirements for binding substrate analogs
Biochim. Biophys. Acta
251
238-250
1971
Bos taurus
Nishihara, H.; Dekker, E.E.
Purification, substrate specificity and binding, beta-decarboxylase activity, and other properties of Escherichia coli 2-keto-4-hydroxyglutarate aldolase
J. Biol. Chem.
247
5079-5087
1972
Escherichia coli, Escherichia coli (P0A955)
Dekker, E.E.; Kobes, R.D.; Grady, S.R.
2-keto-4-Hydroxyglutarate aldolase from bovine liver
Methods Enzymol.
42C
280-285
1975
Bos taurus
Meloche, H.P.; Monti, C.T.; Dekker, E.E.
Enzyme stereoselectivity: the reversible reaction catalyzed by 2-keto-4-hydroxyglutarate aldolase of Escherichia coli
Biochem. Biophys. Res. Commun.
65
1033-1039
1975
Escherichia coli
Hansen, B.A.; Dekker, E.E.
Inactivation of bovine liver 2-keto-4-hydroxyglutarate aldolase by cyanide in the presence of aldehydes
Biochemistry
15
2912-2917
1976
BRENDA: Bos taurus
Textmining: Dialysis
Lane, R.S.; Hansen, B.A.; Dekker, E.E.
Sulfhydryl groups in relation to the structure and catalytic properties of 2-oxo-4-hydroxyglutarate aldolase from bovine liver
Biochim. Biophys. Acta
481
212-221
1977
Bos taurus
Wang, J.K.; Dekker, E.E.; Lewinski, N.D.; Winter, H.C.
Physical and chemical evidence for the trimeric subunit structure of 2-keto-4-hydroxyglutarate aldolase from Escherichia coli K-12
J. Biol. Chem.
256
1793-1800
1981
Escherichia coli K-12
Grady, S.R.; Wang, J.K.; Dekker, E.E.
Steady-state kinetics and inhibition studies of the aldol condensation reaction catalized by bovine liver and Escherichia coli 2-keto-4-hydroxyglutarate aldolase
Biochemistry
20
2497-2502
1981
BRENDA: Bos taurus
Textmining: Escherichia coli
Vlahos, C.J.; Dekker, E.E.
Active-site residues of 2-keto-4-hydroxyglutarate aldolase from Escherichia coli
J. Biol. Chem.
265
20384-20389
1990
Escherichia coli, Escherichia coli (P0A955)
Scholtz, J.M.; Schuster, S.M.
Substrates of hydroxyketoglutarate aldolase
Bioorg. Chem.
12
229-234
1984
Rattus norvegicus
-
Anderson, M.; Scholtz, J.M.; Schuster, S.M.
Rat liver 4-hydroxy-2-ketoglutarate aldolase: purification and kinetic characterization
Arch. Biochem. Biophys.
236
82-97
1985
BRENDA: Rattus norvegicus
Textmining: Rattus
Vlahos, C.J.; Dekker, E.E.
The complete amino acid sequence and identification of the active-site arginine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase
J. Biol. Chem.
263
11683-11691
1988
Escherichia coli, Staphylococcus aureus V8, Pseudomonas putida
Dekker, E.E.; Kitson, R.P.
2-keto-4-Hydroxyglutarate aldolase: purification of the homogeneous enzyme from bovine kidney
J. Biol. Chem.
267
10507-10514
1992
BRENDA: Bos taurus
Textmining: Meniscus, Escherichia coli
Cayrol, C.; Petit, C.; Raynaud, B.; Capdevielle, J.; Guillemot, J.C.; Defais, M.
Recovery of respiration following thew SOS-response of Escherichia coli requires RecA-mediated induction of 2-keto-4-hydroxyglutarate aldolase
Proc. Natl. Acad. Sci. USA
92
11806-11809
1995
Escherichia coli
Patil, R.V.; Dekker, E.E.
Cloning, nucleotide sequence, overexpression, and inactivation of the Escherichia coli 2-keto-4-hydroxyglutarate aldolase gene
J. Bacteriol.
174
102-107
1992
Escherichia coli, Escherichia coli (P0A955), insertion sequences, Escherichia phage M13
Belostotsky, R.; Seboun, E.; Idelson, G.H.; Milliner, D.S.; Becker-Cohen, R.; Rinat, C.; Monico, C.G.; Feinstein, S.; Ben-Shalom, E.; Magen, D.; Weissman, I.; Charon, C.; Frishberg, Y.
Mutations in DHDPSL are responsible for primary hyperoxaluria type III
Am. J. Hum. Genet.
87
392-399
2010
Homo sapiens (Q86XE5), Homo sapiens
Riedel, T.J.; Knight, J.; Murray, M.S.; Milliner, D.S.; Holmes, R.P.; Lowther, W.T.
4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition
Biochim. Biophys. Acta
1822
1544-1552
2012
BRENDA: Homo sapiens (Q86XE5), Homo sapiens
Textmining: Escherichia coli, Cricetulus griseus
Winter, H.C.; Lewinski, N.D.; Wang, J.K.; Dekker, E.E.
Dimerization occurs during the reversible acid inactivation of 2-oxo-4-hydroxyglutarate aldolase from Escherichia coli
Biochim. Biophys. Acta
749
52-61
1983
Escherichia coli
Vlahos, C.J.; Dekker, E.E.
Amino acid sequence of the pyruvate and the glyoxylate active-site lysine peptide of Escherichia coli 2-keto-4-hydroxyglutarate aldolase
J. Biol. Chem.
261
11049-11055
1986
Escherichia coli, Escherichia coli (P0A955), Pseudomonas putida, Clostridium acetobutylicum
Riedel, T.J.; Johnson, L.C.; Knight, J.; Hantgan, R.R.; Holmes, R.P.; Lowther, W.T.
Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria
PLoS ONE
6
e26021
2011
Homo sapiens (Q86XE5), Homo sapiens
Williams, E.L.; Bockenhauer, D.; vant Hoff, W.G.; Johri, N.; Laing, C.; Sinha, M.D.; Unwin, R.; Viljoen, A.; Rumsby, G.
The enzyme 4-hydroxy-2-oxoglutarate aldolase is deficient in primary hyperoxaluria type 3
Nephrol. Dial. Transplant.
27
3191-3195
2012
Homo sapiens (Q86XE5), Homo sapiens
Carnie, J.A.; Rowsell, E.V.; Dabbaghian, M.K.; Hobbs, D.R.; Rowsell, K.V.
Comparative and developmental studies on 4-hydroxy-2-oxoglutarate aldolase and hydroxyproline oxidase
Comp. Biochem. Physiol. B
71
681-687
1982
Rattus
Huang, A.; Baker, E.; Loomes, K.
Use of a novel microtitration protocol to obtain diffraction-quality crystals of 4-hydroxy-2-oxoglutarate aldolase from Bos taurus
Acta Crystallogr. Sect. F
70
1546-1549
2014
BRENDA: Bos taurus (Q0P5I5), Bos taurus
Textmining: Mammalia, Homo sapiens
Schapfl, M.; Baier, S.; Fries, A.; Ferlaino, S.; Waltzer, S.; Mueller, M.; Sprenger, G.A.
Extended substrate range of thiamine diphosphate-dependent MenD enzyme by coupling of two C-C-bonding reactions
Appl. Microbiol. Biotechnol.
102
8359-8372
2018
Escherichia coli (P0A955)
MacDonald, J.R.; Huang, A.D.; Loomes, K.M.
Cellular degradation of 4-hydroxy-2-oxoglutarate aldolase leads to absolute deficiency in primary hyperoxaluria type 3
FEBS Lett.
590
1467-1476
2016
Homo sapiens (Q86XE5)
Mdimegh, S.; Aquaviva-Bourdain, C.; Omezzine, A.; Souche, G.; Mbarek, I.; Abidi, K.; Gargah, T.; Abroug, S.; Bouslama, A.
HOGA1 gene mutations of primary hyperoxaluria type 3 in tunisian patients
J. Clin. Lab. Anal.
31
e22053
2017
Homo sapiens
Lane, RS; Dekker, EE
Effect of tetranitromethane on the aldolase and beta-decarboxylase activities of bovine liver 2-keto-4-hydroxyglutarate aldolase.
Biochem Biophys Res Commun
36
973-9
1969
Bos taurus
Grady, SR; Dekker, EE
Tritium exchange reactions catalyzed by 2-oxo-4-hydroxyglutarate aldolase from Escherichia coli K-12.
Biochim Biophys Acta
568
234-42
1979
Escherichia coli K-12, Escherichia coli
Dekker, EE; Nishihara, H; Grady, SR
2-keto-4-hydroxyglutarate aldolase from Escherichia coli.
Methods Enzymol
42
285-90
1975
Escherichia coli
Vlahos, CJ; Ghalambor, MA; Dekker, EE
Evidence for an essential arginine residue in the active site of Escherichia coli 2-keto-4-hydroxyglutarate aldolase. Modification with 1,2-cyclohexanedione.
J Biol Chem
260
5480-5
1985
Escherichia coli
Scholtz, JM; Schuster, SM
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.
Biochim Biophys Acta
869
192-6
1986
Rattus
Nishihara, H; Dekker, EE
A stereospecific 2-keto-4-hydroxyglutarate aldolase from Escherichia coli.
Biochim Biophys Acta
185
255-7
1969
Escherichia coli
Lane, RS; Dekker, EE
Oxidation of sulfhydryl groups of bovine liver 2-keto-4-hydroxyglutarate aldolase by tetranitromethane.
Biochemistry
11
3295-303
1972
Bos taurus
Kobes, RD; Dekker, EE
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Schiff-base formation with 2-keto-4-hydroxyglutarate, pyruvate, and glyoxylate.
Biochemistry
10
388-95
1971
Bos taurus
Kobes, RD; Dekker, EE
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.
J Biol Chem
244
1919-25
1969
Bos taurus
Kobes, RD; Dekker, EE
Beef liver 2-keto-4-hydroxyglutarate aldolase: substrate stereospecificity and Schiff base formation with pyruvate and glyoxylate.
Biochem Biophys Res Commun
25
329-34
1966
Bos taurus
Kobes, RD; Dekker, EE
An unusual glyoxylate-enzyme complex and beta-decarboxylase activity of beef liver 2-keto-4-hydroxyglutarate aldolase.
Biochem Biophys Res Commun
27
607-12
1967
Bos taurus
Rosso, RG; Adams, E
4-hydroxy-2-ketoglutarate aldolase of rat liver. Purification, binding of substrates, and kinetic properties.
J Biol Chem
242
5524-34
1967
Rattus
MAITRA, U; DEKKER, EE
PURIFICATION AND PROPERTIES OF RAT LIVER 2-KETO-4-HYDROXYGLUTARATE ALDOLASE.
J Biol Chem
239
1485-91
1964
Rattus
Murray, EL; Conway, T
Multiple regulators control expression of the Entner-Doudoroff aldolase (Eda) of Escherichia coli.
J Bacteriol
187
991-1000
2005
Escherichia coli
Fang, X; He, L; Xu, G; Lin, H; Xu, M; Geng, H
Nine novel HOGA1 gene mutations identified in primary hyperoxaluria type 3 and distinct clinical and biochemical characteristics in Chinese children.
Pediatr Nephrol
2019
Homo sapiens
Huang, A; Burke, J; Bunker, RD; Mok, YF; Griffin, MD; Baker, EN; Loomes, KM
Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and ?-ketoglutarate: implications for primary hyperoxaluria type-3.
Biochem J
476
3369-3383
2019
Homo sapiens, Maniola tithonus
Jen, FE; Scott, AL; Tan, A; Seib, KL; Jennings, MP
Random Switching of the ModA11 Type III DNA Methyltransferase of Neisseria meningitidis Regulates Entner-Doudoroff Aldolase Expression by a Methylation Change in the eda Promoter Region.
J Mol Biol
2020
Neisseria meningitidis
Beck, BB; Baasner, A; Buescher, A; Habbig, S; Reintjes, N; Kemper, MJ; Sikora, P; Mache, C; Pohl, M; Stahl, M; Toenshoff, B; Pape, L; Fehrenbach, H; Jacob, DE; Grohe, B; Wolf, MT; Nrnberg, G; Yigit, G; Salido, EC; Hoppe, B
Novel findings in patients with primary hyperoxaluria type III and implications for advanced molecular testing strategies.
Eur J Hum Genet
2012
Homo sapiens
Allard, L; Cochat, P; Leclerc, AL; Cachat, F; Fichtner, C; De Souza, VC; Garcia, CD; Camoin-Schweitzer, MC; Macher, MA; Acquaviva-Bourdain, C; Bacchetta, J
Renal function can be impaired in children with primary hyperoxaluria type 3.
Pediatr Nephrol
30
1807-13
2015
Homo sapiens
Li, X; Knight, J; Todd Lowther, W; Holmes, RP
Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3.
Biochim Biophys Acta
1852
2700-5
2015
Mus musculus
Salvato, RS; Reis, AJ; Schiefelbein, SH; Gmez, MAA; Salvato, SS; da Silva, LV; Costa, ERD; Unis, G; Dias, CF; Viveiros, M; Portugal, I; von Groll, A; da Silva, PEA; Kritski, AL; Perdigo, J; Rossetti, MLR
Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil.
Int J Antimicrob Agents
58
106401
2021
Mycobacterium tuberculosis
Gupta, SC; Dekker, EE
Malyl-CoA formation in the NAD-, CoASH-, and alpha-ketoglutarate dehydrogenase-dependent oxidation of 2-keto-4-hydroxyglutarate. Possible coupled role of this reaction with 2-keto-4-hydroxyglutarate aldolase activity in a pyruvate-catalyzed cyclic oxidation of glyoxylate.
J Biol Chem
259
10012-9
1984
Escherichia coli, Sus scrofa
Wang, X; Zhao, X; Wang, X; Yao, J; Zhang, F; Lang, Y; Tuffery-Giraud, S; Bottillo, I; Shao, L
Two Novel HOGA1 Splicing Mutations Identified in a Chinese Patient with Primary Hyperoxaluria Type 3.
Am J Nephrol
42
78-84
2015
Homo sapiens
Abid, A
Possible ethnic associations in primary hyperoxaluria type-III-associated HOGA1 sequence variants.
Mol Biol Rep
48
3841-3844
2021
Homo sapiens
Grant Pearce, F; Hudson, AO; Loomes, K; Dobson, RCJ
Dihydrodipicolinate Synthase: Structure, Dynamics, Function, and Evolution.
Subcell Biochem
83
271-289
2017
Homo sapiens
Belostotsky, R; Pitt, JJ; Frishberg, Y
Primary hyperoxaluria type III-a model for studying perturbations in glyoxylate metabolism.
J Mol Med (Berl)
2012
Homo sapiens
Williams, EL; Bagg, EA; Mueller, M; Vandrovcova, J; Aitman, TJ; Rumsby, G
Performance evaluation of Sanger sequencing for the diagnosis of primary hyperoxaluria and comparison with targeted next generation sequencing.
Mol Genet Genomic Med
3
69-78
2015
Homo sapiens
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