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Information on EC 4.1.3.1 - isocitrate lyase and Organism(s) Candida albicans and UniProt Accession Q9P8Q7
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4.1.3.1 isocitrate lyaseIUBMB Comments
The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate .
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Word Map
- 4.1.3.1
-
interstrand
- malate
- lens
- eyes
-
collamer
-
postoperative
-
intraocular
-
crosslinks
-
refract
-
preoperative
-
phakic
-
acuity
-
fanconi
- anemia
-
posterior
-
spherical
-
uncorrected
-
myopic
-
vault
-
fork
-
diopter
- corneal
- astigmatism
- glyoxysomal
-
fancd2
- pupil
- lymphocytopenia
-
translesion
-
logmar
- itaconate
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anaplerotic
-
monoubiquitination
- psoralens
-
monoadducts
-
gaba-induced
-
vision-threatening
-
pupillary
-
incisions
-
hyperopic
-
keratomileusis
-
subcapsular
-
lasik
- microbodies
-
biomicroscopy
- drug development
-
snellen
- medicine
-
as-oct
-
best-corrected
- sn-glycerol-3-phosphate
-
spectacle
- molecular biology
- gelatinosa
The taxonomic range for the selected organisms is: Candida albicans
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
icl, isocitrate lyase, citrate lyase, mtbicl, eggce, isocitritase, isocitratase, isocitric lyase, fpicl1, petal death protein, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ICL
isocitrase
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-
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isocitratase
-
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isocitric lyase
-
-
-
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isocitritase
-
-
-
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lyase, isocitrate
-
-
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threo-DS-Isocitrate glyoxylate-lyase
-
-
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ICL
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
condensation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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-
SYSTEMATIC NAME
IUBMB Comments
isocitrate glyoxylate-lyase (succinate-forming)
The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate [3].
CAS REGISTRY NUMBER
COMMENTARY
9045-78-7
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(2R,3R,4S,6E)-2-amino-1,3-dihydroxy-16-methylheptadec-6-en-4-yl hydrogen sulfate
-
(5bR,7aS,11aR,11bS,13R,13aS,13bS)-1-hydroxy-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-13-yl acetate
-
(5bR,7aS,11aS,11bR,13R,13aS,13bR)-1-methoxy-5b,8,8,11a,13a-pentamethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-13-yl acetate
-
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(3-methoxybenzylidene)furan-2(5H)-one
-
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one
i.e. cadiolide H, purified from the ascidian Synoicum sp.
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one
i.e. cadiolide E, purified from the ascidian Synoicum sp.
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-[(2,4-dibromo-3-hydroxyphenyl)methylidene]furan-2(5H)-one
-
(5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one
i.e. cadiolide G, purified from the ascidian Synoicum sp.
1-(5-hydroxy-1H-indol-3-yl)-2-(6-hydroxy-1H-indol-3-yl)ethane-1,2-dione
i.e. hyrtiosin B
dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate
i.e. synoilide A, purified from the ascidian Synoicum sp.
dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate
i.e. synoilide B, purified from the ascidian Synoicum sp.
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
sodium 2,3-dihydroxypropyl (2R)-3-[[10-(2-hexylcyclopropyl)decanoyl]oxy]-2-hydroxypropyl phosphate
-
(1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylic acid
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(2E,6E)-9-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2,6-dimethylnona-2,6-dienal
-
-
(2E,7E)-10-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-3,7-dimethyl-2-(2-methylprop-1-en-1-yl)deca-2,7-dienal
-
-
(2R)-2-[(3E,7E)-9-(hydroxymethyl)-4,8,11-trimethyldodeca-3,7,10-trien-1-yl]-2,8-dimethyl-3,4-dihydro-2H-chromen-6-ol
-
-
(4R,5R)-4-[(2E)-5-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2-methylpent-2-en-1-yl]-2-methyl-5-(2-methylprop-1-en-1-yl)cyclopent-2-en-1-one
-
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(4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(4S,5bS,11aR,13aS,13bR)-11a-formyl-4-hydroxy-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(4S,5bS,11aR,13aS,13bR)-11a-[(acetyloxy)methyl]-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1,4-diyl diacetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(5bS,11aR,13aS,13bR)-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
(5E)-5-[(2R,6E,10E)-13-furan-3-yl-2,6,10-trimethyltrideca-6,10-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
-
linear furanosesterterpene, isolated from Smenospongia sp.
(5Z)-5-[(2R,5Z,9Z)-13-furan-3-yl-2,6,10-trimethyltrideca-5,9-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
-
linear furanosesterterpene, isolated from Smenospongia sp.
1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline
-
weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
12-deacetoxy-23-acetoxy-19-O-acetylscalarin
-
cytotoxic, isolated from Smenospongia sp.
12-deacetoxy-23-hydroxyheteronemin
-
cytotoxic, isolated from Smenospongia sp.
4-hydroxy-9-deoxoidiadione
-
cytotoxic, linear furanosesterterpene, isolated from Smenospongia sp.
5-hydroxy-1H-indole-3-carboxylic acid methyl ester
-
weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
5-hydroxyindole-3-carbaldehyde
-
moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
hyrtiosin A
-
moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
hyrtiosin B
-
strong inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
methyl (1R,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
methyl (1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
serotonin
-
moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methanol
-
scarlarane sesterterpene, isolated from Smenospongia sp.
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methyl acetate
-
scarlarane sesterterpene, isolated from Smenospongia sp.
[(5bS,11aR,13aS,13bR)-1-methoxy-5b,8,8,13a-tetramethyl-1,5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a,13b-hexadecahydrochryseno[1,2-c]furan-11a(3H)-yl]methanol
-
scarlarane sesterterpene, isolated from Smenospongia sp.
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
-
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
i.e. cadiolide I, purified from the ascidian Synoicum sp.
additional information
cadiolide and synoilide ICL inhibitors (5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one, (5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one, (5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one, methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate, dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate and dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate have no inhibitory effects on Candida albicans strain SC5314 grown in glucose, but are inhibitory to strain SC5314 grown in acetate
-
additional information
-
cadiolide and synoilide ICL inhibitors (5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one, (5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one, (5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one, methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate, dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate and dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate have no inhibitory effects on Candida albicans strain SC5314 grown in glucose, but are inhibitory to strain SC5314 grown in acetate
-
additional information
-
6-hydroxy-3,4-dihydro-1-oxo-beta-carboline, isolated from marine sponge Hyrtios sp. (Thorectidae family), defined inactive as inhibitor since IC50 is higher than 0.989 mM at a concentration of 2 mg/ml
-
additional information
-
natural glyoxylate cycle inhibitors such 5-hydroxyindole-type alkaloids are potent inhibitors
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
high enzymic activity of ICL in strains isolated from diabetic patients suffering from vulvovaginal candidiasis. Specific activation of ICL1 when the pathogen is exposed to neutrophils or macrophages
-
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.01716
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(4-methoxybenzylidene)furan-2(5H)-one
Candida albicans
pH and temperature not specified in the publication
0.00762
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-(3,5-dibromo-4-hydroxybenzylidene)furan-2(5H)-one
Candida albicans
pH and temperature not specified in the publication
0.0488
(5Z)-5-(3-bromo-4-hydroxybenzylidene)-4-(3-bromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]furan-2(5H)-one
Candida albicans
pH and temperature not specified in the publication
0.00166
3-nitropropionate
Candida albicans
pH and temperature not specified in the publication
0.07517
dimethyl (2Z)-2-(3,5-dibromo-4-hydroxybenzoyl)-3-(3,5-dibromo-4-hydroxyphenyl)but-2-enedioate
Candida albicans
pH and temperature not specified in the publication
0.1216
dimethyl (2Z)-2-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)but-2-enedioate
Candida albicans
pH and temperature not specified in the publication
0.01036
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
Candida albicans
pH and temperature not specified in the publication
0.01561
(2-bromo-4,5-dihydroxybenzyl)(2,3-dibromo-4,5-dihydroxybenzyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.06819
(2-bromo-4,5-dihydroxyphenyl)(3,4-dihydroxyphenyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.185
(2E,6E)-9-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2,6-dimethylnona-2,6-dienal
Candida albicans
-
pH 7.0, 37°C
0.1729
(2E,7E)-10-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-3,7-dimethyl-2-(2-methylprop-1-en-1-yl)deca-2,7-dienal
Candida albicans
-
pH 7.0, 37°C
0.1184
(2R)-2-[(3E,7E)-9-(hydroxymethyl)-4,8,11-trimethyldodeca-3,7,10-trien-1-yl]-2,8-dimethyl-3,4-dihydro-2H-chromen-6-ol
Candida albicans
-
pH 7.0, 37°C
0.00265
(3-bromo-4,5-dihydroxyphenyl)(2,3-dibromo-4,5-dihydroxyphenyl)methanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.141
(4R,5R)-4-[(2E)-5-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-chromen-2-yl]-2-methylpent-2-en-1-yl]-2-methyl-5-(2-methylprop-1-en-1-yl)cyclopent-2-en-1-one
Candida albicans
-
pH 7.0, 37°C
0.089
1,2-bis(5-hydroxy-1H-indol-3-yl)ethane-1,2-dione
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.301
1-(2-aminoethyl)-1H-indol-6-ol
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.075
1-(3-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.18
1-(4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-b-carboline
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.137
1-(naphthalen-2-yl)-2,3,4,9-tetrahydro-1H-b-carboline
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.01477
2,2',3-tribromo-4,4',5,5'-tetrahydroxybibenzyl
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.02121
2,2'-dibromo-4,4',5,5'-tetrahydroxybibenzyl
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.318
2-hydroxy-1-(5-hydroxy-1H-indol-3-yl)ethanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.0929
3,4-dihydrohyrtiosulawesine
Candida albicans
-
pH and temperature not specified in the publication
0.02806
4,4'-(oxydimethanediyl)bis(5,6-dibromobenzene-1,2-diol)
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.05847
4,4'-ethane-1,2-diyldibenzene-1,2-diol
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.01844
4,4'-methanediylbis(5,6-dibromobenzene-1,2-diol)
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.04615
4,4'-methanediylbis(5-bromobenzene-1,2-diol)
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.247
5-hydroxy-1H-indole-3-carbaldehyde
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.38
6-hydroxy-4,9-dihydro-3H-beta-carboline-1-carboxylic acid
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.01163
bis(2,3-dibromo-4,5-dihydroxyphenyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.03088
bis(2-bromo-4,5-dihydroxyphenyl) ether
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.02258
bis(3,4-dihydroxyphenyl)methanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.00889
bis(3-bromo-4,5-dihydroxyphenyl)methanone
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
additional information
(4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
0.0507
3-nitropropionate
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
0.051
3-nitropropionate
Candida albicans
-
pH not specified in the publication, temperature not specified in the publication
additional information
(4S,5bR,11aS,13aS,13bR)-4-hydroxy-5b,8,8,11a,13a-pentamethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
(4S,5bS,11aR,13aS,13bR)-11a-formyl-4-hydroxy-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
(4S,5bS,11aR,13aS,13bR)-11a-[(acetyloxy)methyl]-5b,8,8,13a-tetramethyl-1,4,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1,4-diyl diacetate
Candida albicans
-
> 0.1 mg/ml
additional information
(5bS,11aR,13aS,13bR)-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-1-yl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
(5E)-5-[(2R,6E,10E)-13-furan-3-yl-2,6,10-trimethyltrideca-6,10-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
Candida albicans
-
0.027 mg/ml
additional information
(5Z)-5-[(2R,5Z,9Z)-13-furan-3-yl-2,6,10-trimethyltrideca-5,9-dien-1-ylidene]-4-hydroxy-3-methylfuran-2(5H)-one
Candida albicans
-
0.0312 mg/ml
additional information
12-deacetoxy-23-acetoxy-19-O-acetylscalarin
Candida albicans
-
> 0.1 mg/ml
additional information
methyl (1R,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
Candida albicans
-
0.055 mg/ml
additional information
methyl (1S,4bS,10aR,12aS)-10a-[(acetyloxy)methyl]-1-formyl-4b,7,7,12a-tetramethyl-1,4,4a,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysene-2-carboxylate
Candida albicans
-
> 0.1 mg/ml
additional information
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methanol
Candida albicans
-
0.0457 mg/ml
additional information
[(5bS,11aR,13aS)-5b,8,8,13a-tetramethyl-5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a-tetradecahydrochryseno[1,2-c]furan-11a(4H)-yl]methyl acetate
Candida albicans
-
> 0.1 mg/ml
additional information
[(5bS,11aR,13aS,13bR)-1-methoxy-5b,8,8,13a-tetramethyl-1,5,5a,5b,6,7,7a,8,9,10,11,11b,12,13,13a,13b-hexadecahydrochryseno[1,2-c]furan-11a(3H)-yl]methanol
Candida albicans
-
0.042 mg/ml
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
-
an ICL-deficient mutant is unable to utilize acetate, ethanol, citrate, glycerol, oleate, lactate, pyruvate, peptone, glutamate or alanine for growth, unlike the parental strain. ICL-deficient mutant is unable to utilize nonfermentable carbon sources and has reduced virulence in mice
physiological function
-
ICL1 contributes to virulence but is not essential for systemic infection. Role for the beta-oxidation pathway in virulence
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). ACEA_CANAX
550
0
61395
Swiss-Prot
other Location (Reliability: 1)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
in bloodstream infection, ICL is downregulated in the initial stages of infection (10 min)
-
is induced in Candida albicans exposed to human neutrophils. In bloodstream infection, ICL is upregulated beginning about 20 min after infection and reaches a 20fold increase after 60 min. ICL expression is detected during growth on Casamino acids, glutamate or peptone, and under starvation conditions
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
drug development
-
isocitrate lyase inhibitor design, substitution of a functional group at position C3 in 5-hydroxyindole-type alkaloids by hydrophilic group increases inhibitory activity
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yang, H.C.; Yu, J.; Oh, K.B.; Shin, D.S.; Cho, W.J.; Shin, J.; Kim, S.
Synthesis and evaluation of hydroquinone derivatives as inhibitors of isocitrate lyase
Arch. Pharm. Res.
30
955-961
2007
Candida albicans
Lee, H.S.; Yoon, K.M.; Han, Y.R.; Lee, K.J.; Chung, S.C.; Kim, T.I.; Lee, S.H.; Shin, J.; Oh, K.B.
5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp
Bioorg. Med. Chem. Lett.
19
1051-1053
2009
Candida albicans
Song, J.; Jeong, W.; Wang, N.; Lee, H.; Sim, C.J.; Oh, K.; Shin, J.
Scalarane Sesterterpenes from the Sponge Smenospongia sp
J. Nat. Prod.
71
1866-1871
2008
Candida albicans
Dunn, M.F.; Ramirez-Trujillo, J.A.; Hernandez-Lucas, I.
Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis
Microbiology
155
3166-3175
2009
Aspergillus fumigatus, Aspergillus nidulans, Candida albicans, Colletotrichum lagenaria, Rhodococcus equi, Cryptococcus neoformans, Escherichia coli, Leptosphaeria maculans, Pyricularia grisea, Mycobacterium tuberculosis, Mycobacterium avium, Yersinia pestis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Sinorhizobium meliloti, Rhizobium tropici, Salmonella enterica subsp. enterica serovar Typhimurium, Yersinia enterocolitica, Paracoccidioides brasiliensis, Brucella suis, Talaromyces marneffei
Oh, K.B.; Jeon, H.B.; Han, Y.R.; Lee, Y.J.; Park, J.; Lee, S.H.; Yang, D.; Kwon, M.; Shin, J.; Lee, H.S.
Bromophenols as Candida albicans isocitrate lyase inhibitors
Bioorg. Med. Chem. Lett.
20
6644-6648
2010
Candida albicans, Candida albicans ATCC 10231
Lee, Y.J.; Han, Y.R.; Park, W.; Nam, S.H.; Oh, K.B.; Lee, H.S.
Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase
Bioorg. Med. Chem. Lett.
20
6882-6885
2010
Candida albicans
Chung, S.C.; Jang, K.H.; Park, J.; Ahn, C.H.; Shin, J.; Oh, K.B.
Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase
Bioorg. Med. Chem. Lett.
21
1958-1961
2011
Candida albicans, Candida albicans ATCC 10231
Ahn, C.H.; Won, T.H.; Kim, H.; Shin, J.; Oh, K.B.
Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.
Bioorg. Med. Chem. Lett.
23
4099-4101
2013
Candida albicans (Q9P8Q7), Candida albicans
Lee, Y.V.; Wahab, H.A.; Choong, Y.S.
Potential inhibitors for isocitrate lyase of Mycobacterium tuberculosis and non-M. tuberculosis a summary
BioMed Res. Int.
2015
895453
2015
Acinetobacter calcoaceticus, Ricinus communis, Escherichia coli, Pyricularia grisea, Mycobacterium tuberculosis, Neurospora crassa, Vogesella indigofera, Candida albicans (Q9P8Q7)
Park, S.; Lee, Y.; Won, H.; Oh, K.; Lee, H.
Indole alkaloids from tropical sponge Hyrtios sp. as isocitrate lyase inhibitors
Nat. Prod. Commun.
13
683-685
2018
Candida albicans
-
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